Harvard Catalyst Profiles

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Marc J. Kaufman, Ph.D.

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Biography
1997 - 2002
Mentored Career Development Award (K01), NIDA
1998 - 1998
Alfred Pope Award for Young Investigators, McLean Hospital
2004 - 2009
Independent Scientist Award (K02), NIDA
2010 - 2010
Jack H. Mendelson Memorial Research Award, McLean Hospital
2011 - 2012
Rapid Response Innovation Award, Michael J. Fox Foundation for Parkinson's Research
2011 - 2013
Independent Investigator Award, NARSAD
2013 - 2017
Board of Directors, College on Problems of Drug Dependence
2015 - 2018
Charter Member, NIH Addiction Risks and Mechanisms Study Section
2020 - 2020
SUD Startup 2020 Competition Award

Overview
My primary scientific aim is to establish translational neuroimaging models to develop novel treatments for addiction, psychiatric, and neurodegenerative disorders. I maintain active clinical and preclinical neuroimaging programs involving magnetic resonance imaging (MRI), functional MRI (fMRI), and magnetic resonance spectroscopy (MRS) studies relevant to substance dependence, schizophrenia, PTSD, and Parkinson’s Disease. I am Director of the Translational Imaging Laboratory at McLean Hospital. I oversee implementation and optimization of animal imaging protocols that form a translational bridge to human neuroimaging studies. I recently initiated research into novel survey and biomarker methods to identify individuals at risk for suicide.

I serve as a Member of Institutional Review Board 1 of the Partners Human Research Committee.

I actively participate as a mentor of young investigators at McLean Hospital and elsewhere. I am a Co-Director of the Training in Drug Abuse and Brain Imaging T32 postdoctoral program (PI: Lukas).

I am very interested in scientific communications and served as a member of the Media Relations Committee for the College on Problems of Drug Dependence (CPDD). I served as Chair of that Committee from 2005-2013 and subsequently on the Board of Directors of the College.

In summary, my aims are to use neuroimaging to better diagnose and treat addiction, psychiatric, and neurodegenerative disorders, to mentor and train the next generation of neuroimaging researchers, and to improve communication of scientific information to the public.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DA055568 (MCLAUGHLIN, JAY P.) Apr 1, 2023 - Jan 31, 2028
    NIH
    Impacts of morphine and HIV-Tat exposures and dimethylfumarate treatment on brain BDNF and mitochondrial and behavioral dysfunction.
    Role: Co-Principal Investigator
  2. R41DA055403 (BOGIN, VLAD) Sep 30, 2021 - Sep 29, 2022
    NIH
    Portable hand-held proprietary xenon inhaler for rapid reduction of opioid withdrawal symptoms
    Role: Co-Principal Investigator
  3. U18DA052344 (KAUFMAN, MARC J) Sep 30, 2020 - Sep 29, 2021
    NIH
    Dimethyl fumarate attenuation of opioid withdrawal symptom severity
    Role: Principal Investigator
  4. R01DA041866 (KAUFMAN, MARC J) Sep 1, 2017 - Jun 30, 2022
    NIH
    Brain effects of long-term anabolic-androgenic steroid use:Multimodal imaging and cognition studies
    Role: Principal Investigator
  5. R21DA039301 (KAUFMAN, MARC J) Sep 15, 2015 - Feb 28, 2018
    NIH
    Effects of chronic cocaine on cognition and glutamate levels in nonhuman primates
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.