Harvard Catalyst Profiles

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Marc J. Kaufman, Ph.D.

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Biography
1997 - 2002
Mentored Career Development Award (K01), NIDA
1998 - 1998
Alfred Pope Award for Young Investigators, McLean Hospital
2004 - 2009
Independent Scientist Award (K02), NIDA
2010 - 2010
Jack H. Mendelson Memorial Research Award, McLean Hospital
2011 - 2012
Rapid Response Innovation Award, Michael J. Fox Foundation for Parkinson's Research
2011 - 2013
Independent Investigator Award, NARSAD
2013 - 2017
Board of Directors, College on Problems of Drug Dependence
2015 - 2018
Charter Member, NIH Addiction Risks and Mechanisms Study Section

Overview
My primary scientific aim is to establish translational neuroimaging models to develop novel treatments for addiction, psychiatric, and neurodegenerative disorders. I maintain active clinical and preclinical neuroimaging programs involving magnetic resonance imaging (MRI), functional MRI (fMRI), and magnetic resonance spectroscopy (MRS) studies relevant to substance dependence, schizophrenia, PTSD, and Parkinson’s Disease. I am Director of the Translational Imaging Laboratory at McLean Hospital that houses a 9.4 Tesla Animal Neuroimaging Facility. I oversee implementation and optimization of animal imaging protocols that form a translational bridge to human neuroimaging studies.

In addition, I serve as a Member of MGH Institutional Review Board B of the Partners Human Research Committee.

I actively participate as a primary and secondary mentor for a number of young investigators at McLean Hospital and elsewhere. I am a Co-Director of the Training in Drug Abuse and Brain Imaging T32 postdoctoral program (PI: Lukas).

I am very interested in scientific communications and since 1999 have served as a member of the Media Relations Committee for the College on Problems of Drug Dependence (CPDD). I served as Chair of that Committee from 2005-2013. I currently am an elected member of the CPDD Board of Directors. I was recently nominated to serve as a Charter Member of the new Addiction Risks and Mechanisms Study Section (2015-2018), Center for Scientific Review, NIH.

In summary, my aims are to use neuroimaging to better diagnose and treat addiction, psychiatric, and neurodegenerative disorders, to mentor and train the next generation of neuroimaging researchers, and to improve communication of scientific information to the public.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U18DA052344 (KAUFMAN, MARC J) Sep 30, 2020 - Sep 29, 2021
    NIH
    Dimethyl fumarate attenuation of opioid withdrawal symptom severity
    Role: Principal Investigator
  2. R01DA041866 (KAUFMAN, MARC J) Sep 1, 2017 - Jun 30, 2022
    NIH
    Brain effects of long-term anabolic-androgenic steroid use:Multimodal imaging and cognition studies
    Role: Principal Investigator
  3. R21DA039301 (KAUFMAN, MARC J) Sep 15, 2015 - Aug 31, 2017
    NIH
    Effects of chronic cocaine on cognition and glutamate levels in nonhuman primates
    Role: Principal Investigator
  4. R01DA039044 (MCLAUGHLIN, JAY P.) Aug 1, 2015 - May 31, 2021
    NIH
    HIV Tat protein mediation of neurochemical changes and increased opioid reward
    Role: Principal Investigator
  5. R03NS080073 (KAUFMAN, MARC J) Jul 1, 2012 - Jun 30, 2014
    NIH
    Is xenon neuroprotective in a mouse model of ALS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Paris JJ, Chen X, Anderson J, Qrareya AN, Mahdi F, Du F, McLaughlin JP, Kaufman MJ. In vivo proton magnetic resonance spectroscopy detection of metabolite abnormalities in aged Tat-transgenic mouse brain. Geroscience. 2021 Apr 05. PMID: 33818687.
    Citations:    Fields:    
  2. Kaufman MJ, Fitzmaurice GM. Temporal patterns of suicide and circulatory system disease-related mortality are inversely correlated in several countries. BMC Psychiatry. 2021 Mar 16; 21(1):153. PMID: 33726707.
    Citations:    Fields:    
  3. Kohut SJ, Kaufman MJ. Magnetic resonance spectroscopy studies of substance use disorders: Current landscape and potential future directions. Pharmacol Biochem Behav. 2021 Jan; 200:173090. PMID: 33333132.
    Citations:    Fields:    
  4. Kohut SJ, Mintzopoulos D, Kangas BD, Shields H, Brown K, Gillis TE, Rohan ML, Bergman J, Kaufman MJ. Effects of long-term cocaine self-administration on brain resting-state functional connectivity in nonhuman primates. Transl Psychiatry. 2020 12 02; 10(1):420. PMID: 33268770.
    Citations:    Fields:    
  5. Hudson JI, Kanayama G, Pope HG, Muse S, Kaufman MJ, Baggish A, Waikar SS. Glomerular Filtration Rate and Supraphysiologic-Dose Anabolic-Androgenic Steroid Use: A Cross-sectional Cohort Study. Am J Kidney Dis. 2020 07; 76(1):152-155. PMID: 32362416.
    Citations: 1     Fields:    Translation:Humans
  6. Bodkin JA, Coleman MJ, Godfrey LJ, Carvalho CMB, Morgan CJ, Suckow RF, Anderson T, Öngür D, Kaufman MJ, Lewandowski KE, Siegel AJ, Waldstreicher E, Grochowski CM, Javitt DC, Rujescu D, Hebbring S, Weinshilboum R, Rodriguez SB, Kirchhoff C, Visscher T, Vuckovic A, Fialkowski A, McCarthy S, Malhotra D, Sebat J, Goff DC, Hudson JI, Lupski JR, Coyle JT, Rudolph U, Levy DL. Targeted Treatment of Individuals With Psychosis Carrying a Copy Number Variant Containing a Genomic Triplication of the Glycine Decarboxylase Gene. Biol Psychiatry. 2019 10 01; 86(7):523-535. PMID: 31279534.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  7. Kangas BD, Doyle RJ, Kohut SJ, Bergman J, Kaufman MJ. Effects of chronic cocaine self-administration and N-acetylcysteine on learning, cognitive flexibility, and reinstatement in nonhuman primates. Psychopharmacology (Berl). 2019 Jul; 236(7):2143-2153. PMID: 30877326.
    Citations: 2     Fields:    Translation:Animals
  8. Kaufman MJ, Kanayama G, Hudson JI, Pope HG. Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia? Neurosci Biobehav Rev. 2019 05; 100:180-207. PMID: 30817935.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  9. Mintzopoulos D, Ratai EM, He J, Gonzalez RG, Kaufman MJ. Simian immunodeficiency virus transiently increases brain temperature in rhesus monkeys: detection with magnetic resonance spectroscopy thermometry. Magn Reson Med. 2019 05; 81(5):2896-2904. PMID: 30652349.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Kanayama G, Kaufman MJ, Pope HG. Public health impact of androgens. Curr Opin Endocrinol Diabetes Obes. 2018 06; 25(3):218-223. PMID: 29369918.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  11. Kim SY, Kaufman MJ, Cohen BM, Jensen JE, Coyle JT, Du F, Öngür D. In Vivo Brain Glycine and Glutamate Concentrations in Patients With First-Episode Psychosis Measured by Echo Time-Averaged Proton Magnetic Resonance Spectroscopy at 4T. Biol Psychiatry. 2018 03 15; 83(6):484-491. PMID: 29031411.
    Citations: 4     Fields:    Translation:Humans
  12. McLaughlin JP, Paris JJ, Mintzopoulos D, Hymel KA, Kim JK, Cirino TJ, Gillis TE, Eans SO, Vitaliano GD, Medina JM, Krapf RC, Stacy HM, Kaufman MJ. Conditional Human Immunodeficiency Virus Transactivator of Transcription Protein Expression Induces Depression-like Effects and Oxidative Stress. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Oct; 2(7):599-609. PMID: 29057370.
    Citations: 4     Fields:    
  13. Mintzopoulos D, Gillis TE, Tedford CE, Kaufman MJ. Effects of Near-Infrared Light on Cerebral Bioenergetics Measured with Phosphorus Magnetic Resonance Spectroscopy. Photomed Laser Surg. 2017 Aug; 35(8):395-400. PMID: 28186868.
    Citations: 2     Fields:    Translation:Animals
  14. Seitz J, Lyall AE, Kanayama G, Makris N, Hudson JI, Kubicki M, Pope HG, Kaufman MJ. White matter abnormalities in long-term anabolic-androgenic steroid users: A pilot study. Psychiatry Res Neuroimaging. 2017 Feb 28; 260:1-5. PMID: 27988413.
    Citations: 5     Fields:    Translation:Humans
  15. Kaufman MJ, Jensen JE. Regarding "2-Deoxy-D-Glucose Enhances Anesthetic Effects in Mice". Anesth Analg. 2016 Apr; 122(4):1224-5. PMID: 26991629.
    Citations:    Fields:    Translation:HumansAnimals
  16. Brennan BP, Jensen JE, Perriello C, Pope HG, Jenike MA, Hudson JI, Rauch SL, Kaufman MJ. LOWER POSTERIOR CINGULATE CORTEX GLUTATHIONE LEVELS IN OBSESSIVE-COMPULSIVE DISORDER. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Feb 01; 1(2):116-124. PMID: 26949749.
    Citations: 7     Fields:    
  17. Mintzopoulos D, Gillis TE, Robertson HR, Dalia T, Feng G, Rauch SL, Kaufman MJ. Striatal magnetic resonance spectroscopy abnormalities in young adult SAPAP3 knockout mice. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Jan 01; 1(1):39-48. PMID: 26858992.
    Citations: 6     Fields:    
  18. Kaufman MJ, Janes AC, Hudson JI, Brennan BP, Kanayama G, Kerrigan AR, Jensen JE, Pope HG. Brain and cognition abnormalities in long-term anabolic-androgenic steroid users. Drug Alcohol Depend. 2015 Jul 01; 152:47-56. PMID: 25986964.
    Citations: 18     Fields:    Translation:Humans
  19. Carey AN, Liu X, Mintzopoulos D, Paris JJ, McLaughlin JP, Kaufman MJ. Conditional Tat protein brain expression in the GT-tg bigenic mouse induces cerebral fractional anisotropy abnormalities. Curr HIV Res. 2015; 13(1):3-9. PMID: 25619988.
    Citations: 4     Fields:    Translation:Animals
  20. Puhl MD, Mintzopoulos D, Jensen JE, Gillis TE, Konopaske GT, Kaufman MJ, Coyle JT. In vivo magnetic resonance studies reveal neuroanatomical and neurochemical abnormalities in the serine racemase knockout mouse model of schizophrenia. Neurobiol Dis. 2015 Jan; 73:269-74. PMID: 25461193.
    Citations: 15     Fields:    Translation:Animals
  21. Meloni EG, Gillis TE, Manoukian J, Kaufman MJ. Xenon impairs reconsolidation of fear memories in a rat model of post-traumatic stress disorder (PTSD). PLoS One. 2014; 9(8):e106189. PMID: 25162644.
    Citations: 10     Fields:    Translation:Animals
  22. Hwang J, Kim JE, Kaufman MJ, Renshaw PF, Yoon S, Yurgelun-Todd DA, Choi Y, Jun C, Lyoo IK. Enlarged cavum septum pellucidum as a neurodevelopmental marker in adolescent-onset opiate dependence. PLoS One. 2013; 8(10):e78590. PMID: 24205275.
    Citations: 6     Fields:    Translation:Humans
  23. Kaufman MJ, Janes AC, Frederick Bd, Brimson-Théberge M, Tong Y, McWilliams SB, Bear A, Gillis TE, Schrode KM, Renshaw PF, Negus SS. A method for conducting functional MRI studies in alert nonhuman primates: initial results with opioid agonists in male cynomolgus monkeys. Exp Clin Psychopharmacol. 2013 Aug; 21(4):323-31. PMID: 23773004.
    Citations: 2     Fields:    Translation:AnimalsCells
  24. Ogata N, Gillis TE, Liu X, Cunningham SM, Lowen SB, Adams BL, Sutherland-Smith J, Mintzopoulos D, Janes AC, Dodman NH, Kaufman MJ. Brain structural abnormalities in Doberman pinschers with canine compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 01; 45:1-6. PMID: 23590875.
    Citations: 5     Fields:    Translation:AnimalsCells
  25. Carey AN, Liu X, Mintzopoulos D, Paris JJ, Muschamp JW, McLaughlin JP, Kaufman MJ. Conditional Tat protein expression in the GT-tg bigenic mouse brain induces gray matter density reductions. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jun 03; 43:49-54. PMID: 23269344.
    Citations: 21     Fields:    Translation:AnimalsCells
  26. Gillis TE, Janes AC, Kaufman MJ. Positive reinforcement training in squirrel monkeys using clicker training. Am J Primatol. 2012 Aug; 74(8):712-20. PMID: 22553135.
    Citations: 10     Fields:    Translation:Animals
  27. Janes AC, Nickerson LD, Frederick Bde B, Kaufman MJ. Prefrontal and limbic resting state brain network functional connectivity differs between nicotine-dependent smokers and non-smoking controls. Drug Alcohol Depend. 2012 Oct 01; 125(3):252-9. PMID: 22459914.
    Citations: 56     Fields:    Translation:Humans
  28. Carey AN, Sypek EI, Singh HD, Kaufman MJ, McLaughlin JP. Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse. Behav Brain Res. 2012 Apr 01; 229(1):48-56. PMID: 22197678.
    Citations: 69     Fields:    Translation:AnimalsCells
  29. Evins AE, Pachas G, Mischoulon D, Urbanoski K, Carlini S, Sousa J, Bentley K, Rigotti NA, Nino-Gomez J, Loebl T, Janes AC, Kaufman MJ, Fava M. A double-blind, placebo-controlled trial of the NMDA glycine site antagonist, GW468816, for prevention of relapse to smoking in females. J Clin Psychopharmacol. 2011 Oct; 31(5):597-602. PMID: 21869693.
    Citations: 6     Fields:    Translation:HumansPHPublic Health
  30. Janes AC, Smoller JW, David SP, Frederick BD, Haddad S, Basu A, Fava M, Evins AE, Kaufman MJ. Association between CHRNA5 genetic variation at rs16969968 and brain reactivity to smoking images in nicotine dependent women. Drug Alcohol Depend. 2012 Jan 01; 120(1-3):7-13. PMID: 21764527.
    Citations: 17     Fields:    Translation:Humans
  31. Mashhoon Y, Janes AC, Jensen JE, Prescot AP, Pachas G, Renshaw PF, Fava M, Evins AE, Kaufman MJ. Anterior cingulate proton spectroscopy glutamate levels differ as a function of smoking cessation outcome. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15; 35(7):1709-13. PMID: 21616118.
    Citations: 13     Fields:    Translation:Humans
  32. Liu X, Jensen JE, Gillis TE, Zuo CS, Prescot AP, Brimson M, Cayetano K, Renshaw PF, Kaufman MJ. Chronic cocaine exposure induces putamen glutamate and glutamine metabolite abnormalities in squirrel monkeys. Psychopharmacology (Berl). 2011 Oct; 217(3):367-75. PMID: 21494788.
    Citations: 6     Fields:    Translation:Animals
  33. Janes AC, Pizzagalli DA, Richardt S, Frederick Bde B, Holmes AJ, Sousa J, Fava M, Evins AE, Kaufman MJ. Neural substrates of attentional bias for smoking-related cues: an FMRI study. Neuropsychopharmacology. 2010 Nov; 35(12):2339-45. PMID: 20703221.
    Citations: 39     Fields:    Translation:Humans
  34. Wells AM, Janes AC, Liu X, Deschepper CF, Kaufman MJ, Kantak KM. Medial temporal lobe functioning and structure in the spontaneously hypertensive rat: comparison with Wistar-Kyoto normotensive and Wistar-Kyoto hypertensive strains. Hippocampus. 2010 Jun; 20(6):787-97. PMID: 19623608.
    Citations: 9     Fields:    Translation:Animals
  35. Janes AC, Pizzagalli DA, Richardt S, deB Frederick B, Chuzi S, Pachas G, Culhane MA, Holmes AJ, Fava M, Evins AE, Kaufman MJ. Brain reactivity to smoking cues prior to smoking cessation predicts ability to maintain tobacco abstinence. Biol Psychiatry. 2010 Apr 15; 67(8):722-9. PMID: 20172508.
    Citations: 189     Fields:    Translation:Humans
  36. Janes AC, Frederick Bd, Richardt S, Burbridge C, Merlo-Pich E, Renshaw PF, Evins AE, Fava M, Kaufman MJ. Brain fMRI reactivity to smoking-related images before and during extended smoking abstinence. Exp Clin Psychopharmacol. 2009 Dec; 17(6):365-73. PMID: 19968401.
    Citations: 27     Fields:    Translation:Humans
  37. Kaufman MJ, Prescot AP, Ongur D, Evins AE, Barros TL, Medeiros CL, Covell J, Wang L, Fava M, Renshaw PF. Oral glycine administration increases brain glycine/creatine ratios in men: a proton magnetic resonance spectroscopy study. Psychiatry Res. 2009 Aug 30; 173(2):143-9. PMID: 19556112.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  38. Yamamoto RT, Teter CJ, Barros TL, McCarthy E, Mileti C, Juliano T, Medeiros CL, Looby A, Maywalt MA, McNeil JF, Olson D, Mallya G, Lukas SE, Renshaw PF, Kaufman MJ. Antiandrogen pretreatment alters cocaine pharmacokinetics in men. J Addict Med. 2007 Dec; 1(4):198-204. PMID: 21768958.
    Citations:    Fields:    
  39. Kaufman MJ, Streeter CC, Barros TL, Sarid-Segal O, Afshar M, Tian H, Rouse ED, Foy KK, Brimson ML, Archambault CA, Renshaw PF, Ciraulo DA. Reduced Plasma Nitric Oxide End Products in Cocaine-dependent Men. J Addict Med. 2007 Jun; 1(2):96-103. PMID: 21768941.
    Citations: 1     Fields:    
  40. Sim ME, Lyoo IK, Streeter CC, Covell J, Sarid-Segal O, Ciraulo DA, Kim MJ, Kaufman MJ, Yurgelun-Todd DA, Renshaw PF. Cerebellar gray matter volume correlates with duration of cocaine use in cocaine-dependent subjects. Neuropsychopharmacology. 2007 Oct; 32(10):2229-37. PMID: 17299505.
    Citations: 64     Fields:    Translation:Humans
  41. Anderson CM, Maas LC, Frederick Bd, Bendor JT, Spencer TJ, Livni E, Lukas SE, Fischman AJ, Madras BK, Renshaw PF, Kaufman MJ. Cerebellar vermis involvement in cocaine-related behaviors. Neuropsychopharmacology. 2006 Jun; 31(6):1318-26. PMID: 16237382.
    Citations: 37     Fields:    Translation:HumansCTClinical Trials
  42. Gruber SA, Tzilos GK, Silveri MM, Pollack M, Renshaw PF, Kaufman MJ, Yurgelun-Todd DA. Methadone maintenance improves cognitive performance after two months of treatment. Exp Clin Psychopharmacol. 2006 May; 14(2):157-64. PMID: 16756419.
    Citations: 21     Fields:    Translation:Humans
  43. Prescot AP, de B Frederick B, Wang L, Brown J, Jensen JE, Kaufman MJ, Renshaw PF. In vivo detection of brain glycine with echo-time-averaged (1)H magnetic resonance spectroscopy at 4.0 T. Magn Reson Med. 2006 Mar; 55(3):681-6. PMID: 16453318.
    Citations: 13     Fields:    Translation:Humans
  44. Lyoo IK, Pollack MH, Silveri MM, Ahn KH, Diaz CI, Hwang J, Kim SJ, Yurgelun-Todd DA, Kaufman MJ, Renshaw PF. Prefrontal and temporal gray matter density decreases in opiate dependence. Psychopharmacology (Berl). 2006 Jan; 184(2):139-44. PMID: 16369836.
    Citations: 50     Fields:    Translation:HumansCells
  45. Anderson CM, Kaufman MJ, Lowen SB, Rohan M, Renshaw PF, Teicher MH. Brain T2 relaxation times correlate with regional cerebral blood volume. MAGMA. 2005 Mar; 18(1):3-6. PMID: 15592693.
    Citations: 12     Fields:    Translation:HumansCTClinical Trials
  46. Silveri MM, Anderson CM, McNeil JF, Diaz CI, Lukas SE, Mendelson JH, Renshaw PF, Kaufman MJ. Oral methylphenidate challenge selectively decreases putaminal T2 in healthy subjects. Drug Alcohol Depend. 2004 Nov 11; 76(2):173-80. PMID: 15488341.
    Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
  47. Silveri MM, Pollack MH, Diaz CI, Nassar LE, Mendelson JH, Yurgelun-Todd DA, Renshaw PF, Kaufman MJ. Cerebral phosphorus metabolite and transverse relaxation time abnormalities in heroin-dependent subjects at onset of methadone maintenance treatment. Psychiatry Res. 2004 Sep 15; 131(3):217-26. PMID: 15465291.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  48. Lyoo IK, Streeter CC, Ahn KH, Lee HK, Pollack MH, Silveri MM, Nassar L, Levin JM, Sarid-Segal O, Ciraulo DA, Renshaw PF, Kaufman MJ. White matter hyperintensities in subjects with cocaine and opiate dependence and healthy comparison subjects. Psychiatry Res. 2004 Jul 30; 131(2):135-45. PMID: 15313520.
    Citations: 31     Fields:    Translation:Humans
  49. Babb SM, Ke Y, Lange N, Kaufman MJ, Renshaw PF, Cohen BM. Oral choline increases choline metabolites in human brain. Psychiatry Res. 2004 Jan 15; 130(1):1-9. PMID: 14972364.
    Citations: 15     Fields:    Translation:Humans
  50. Kaufman MJ, Henry ME, Frederick Bd, Hennen J, Villafuerte RA, Stoddard EP, Schmidt ME, Cohen BM, Renshaw PF. Selective serotonin reuptake inhibitor discontinuation syndrome is associated with a rostral anterior cingulate choline metabolite decrease: a proton magnetic resonance spectroscopic imaging study. Biol Psychiatry. 2003 Sep 01; 54(5):534-9. PMID: 12946882.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  51. Henry ME, Kaufman MJ, Hennen J, Michelson D, Schmidt ME, Stoddard E, Vukovic AJ, Barreira PJ, Cohen BM, Renshaw PF. Cerebral blood volume and clinical changes on the third day of placebo substitution for SSRI treatment. Biol Psychiatry. 2003 Jan 01; 53(1):100-5. PMID: 12513950.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  52. Levin JM, Frederick Bde B, Ross MH, Fox JF, von Rosenberg HL, Kaufman MJ, Lange N, Mendelson JH, Cohen BM, Renshaw PF. Influence of baseline hematocrit and hemodilution on BOLD fMRI activation. Magn Reson Imaging. 2001 Oct; 19(8):1055-62. PMID: 11711229.
    Citations: 32     Fields:    Translation:Humans
  53. Henry ME, Kaufman MJ, Lange N, Schmidt ME, Purcell S, Cote J, Perron-Henry DM, Stoddard E, Cohen BM, Renshaw PF. Test-retest reliability of DSC MRI CBV mapping in healthy volunteers. Neuroreport. 2001 Jun 13; 12(8):1567-9. PMID: 11409717.
    Citations: 9     Fields:    Translation:Humans
  54. Kaufman MJ, Levin JM, Maas LC, Kukes TJ, Villafuerte RA, Dostal K, Lukas SE, Mendelson JH, Cohen BM, Renshaw PF. Cocaine-induced cerebral vasoconstriction differs as a function of sex and menstrual cycle phase. Biol Psychiatry. 2001 May 01; 49(9):774-81. PMID: 11331085.
    Citations: 15     Fields:    Translation:Humans
  55. Christensen JD, Kaufman MJ, Frederick B, Rose SL, Moore CM, Lukas SE, Mendelson JH, Cohen BM, Renshaw PF. Proton magnetic resonance spectroscopy of human basal ganglia: response to cocaine administration. Biol Psychiatry. 2000 Oct 01; 48(7):685-92. PMID: 11032980.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  56. Henry ME, Moore CM, Kaufman MJ, Michelson D, Schmidt ME, Stoddard E, Vuckevic AJ, Berreira PJ, Cohen BM, Renshaw PF. Brain kinetics of paroxetine and fluoxetine on the third day of placebo substitution: a fluorine MRS study. Am J Psychiatry. 2000 Sep; 157(9):1506-8. PMID: 10964871.
    Citations: 13     Fields:    Translation:HumansCTClinical Trials
  57. Kaufman MJ, Levin JM, Kukes TJ, Villafuerte RA, Hennen J, Lukas SE, Mendelson JH, Renshaw PF. Illicit cocaine use patterns in intravenous-naive cocaine users following investigational intravenous cocaine administration. Drug Alcohol Depend. 2000 Feb 01; 58(1-2):35-42. PMID: 10669053.
    Citations: 5     Fields:    Translation:Humans
  58. Siegel AJ, Sholar MB, Mendelson JH, Lukas SE, Kaufman MJ, Renshaw PF, McDonald JC, Lewandrowski KB, Apple FS, Stec JJ, Lipinska I, Tofler GH, Ridker PM. Cocaine-induced erythrocytosis and increase in von Willebrand factor: evidence for drug-related blood doping and prothrombotic effects. Arch Intern Med. 1999 Sep 13; 159(16):1925-9. PMID: 10493323.
    Citations: 8     Fields:    Translation:Humans
  59. Mendelson JH, Mello NK, Sholar MB, Siegel AJ, Kaufman MJ, Levin JM, Renshaw PF, Cohen BM. Cocaine pharmacokinetics in men and in women during the follicular and luteal phases of the menstrual cycle. Neuropsychopharmacology. 1999 Aug; 21(2):294-303. PMID: 10432477.
    Citations: 42     Fields:    Translation:Humans
  60. Kaufman MJ, Pollack MH, Villafuerte RA, Kukes TJ, Rose SL, Mendelson JH, Cohen BM, Renshaw PF. Cerebral phosphorus metabolite abnormalities in opiate-dependent polydrug abusers in methadone maintenance. Psychiatry Res. 1999 Jun 30; 90(3):143-52. PMID: 10466733.
    Citations: 12     Fields:    Translation:Humans
  61. Kaufman MJ, Siegel AJ, Mendelson JH, Rose SL, Kukes TJ, Sholar MB, Lukas SE, Renshaw PF. Cocaine administration induces human splenic constriction and altered hematologic parameters. J Appl Physiol (1985). 1998 Nov; 85(5):1877-83. PMID: 9804594.
    Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
  62. Kaufman MJ, Levin JM, Maas LC, Rose SL, Lukas SE, Mendelson JH, Cohen BM, Renshaw PF. Cocaine decreases relative cerebral blood volume in humans: a dynamic susceptibility contrast magnetic resonance imaging study. Psychopharmacology (Berl). 1998 Jul; 138(1):76-81. PMID: 9694529.
    Citations: 12     Fields:    Translation:Humans
  63. Levin JM, Ross MH, Mendelson JH, Kaufman MJ, Lange N, Maas LC, Mello NK, Cohen BM, Renshaw PF. Reduction in BOLD fMRI response to primary visual stimulation following alcohol ingestion. Psychiatry Res. 1998 Jun 30; 82(3):135-46. PMID: 9754438.
    Citations: 41     Fields:    Translation:HumansCTClinical Trials
  64. Madras BK, Gracz LM, Meltzer PC, Liang AY, Elmaleh DR, Kaufman MJ, Fischman AJ. Altropane, a SPECT or PET imaging probe for dopamine neurons: II. Distribution to dopamine-rich regions of primate brain. Synapse. 1998 Jun; 29(2):105-15. PMID: 9593101.
    Citations: 5     Fields:    Translation:Animals
  65. Streeter CC, Ciraulo DA, Harris GJ, Kaufman MJ, Lewis RF, Knapp CM, Ciraulo AM, Maas LC, Ungeheuer M, Szulewski S, Renshaw PF. Functional magnetic resonance imaging of alprazolam-induced changes in humans with familial alcoholism. Psychiatry Res. 1998 May 20; 82(2):69-82. PMID: 9754450.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  66. Sholar MB, Mendelson JH, Mello NK, Siegel AJ, Kaufman MJ, Levin JM, Renshaw PF, Cohen BM. Concurrent pharmacokinetic analysis of plasma cocaine and adrenocorticotropic hormone in men. J Clin Endocrinol Metab. 1998 Mar; 83(3):966-8. PMID: 9506757.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  67. Kaufman MJ, Levin JM, Ross MH, Lange N, Rose SL, Kukes TJ, Mendelson JH, Lukas SE, Cohen BM, Renshaw PF. Cocaine-induced cerebral vasoconstriction detected in humans with magnetic resonance angiography. JAMA. 1998 Feb 04; 279(5):376-80. PMID: 9459471.
    Citations: 29     Fields:    Translation:HumansCTClinical Trials
  68. Levin JM, Wald LL, Kaufman MJ, Ross MH, Maas LC, Renshaw PF. T1 effects in sequential dynamic susceptibility contrast experiments. J Magn Reson. 1998 Feb; 130(2):292-5. PMID: 9500901.
    Citations: 8     Fields:    Translation:Humans
  69. Maas LC, Lukas SE, Kaufman MJ, Weiss RD, Daniels SL, Rogers VW, Kukes TJ, Renshaw PF. Functional magnetic resonance imaging of human brain activation during cue-induced cocaine craving. Am J Psychiatry. 1998 Jan; 155(1):124-6. PMID: 9433350.
    Citations: 126     Fields:    Translation:Humans
  70. English CD, Kaufman MJ, Worth JL, Babb SM, Drebing CE, Navia BA, Renshaw PF. Elevated frontal lobe cytosolic choline levels in minimal or mild AIDS dementia complex patients: a proton magnetic resonance spectroscopy study. Biol Psychiatry. 1997 Feb 15; 41(4):500-2. PMID: 9034546.
    Citations: 2     Fields:    Translation:Humans
  71. Renshaw PF, Levin JM, Kaufman MJ, Ross MH, Lewis RF, Harris GJ. Dynamic susceptibility contrast magnetic resonance imaging in neuropsychiatry: present utility and future promise. Eur Radiol. 1997; 7 Suppl 5:216-21. PMID: 9370546.
    Citations: 6     Fields:    Translation:Humans
  72. Christensen JD, Kaufman MJ, Levin JM, Mendelson JH, Holman BL, Cohen BM, Renshaw PF. Abnormal cerebral metabolism in polydrug abusers during early withdrawal: a 31P MR spectroscopy study. Magn Reson Med. 1996 May; 35(5):658-63. PMID: 8722816.
    Citations: 12     Fields:    Translation:Humans
  73. Kaufman MJ, Hirata F. Cyclic GMP inhibits phosphoinositide turnover in choroid plexus: evidence for interactions between second messengers concurrently triggered by 5-HT2C receptors. Neurosci Lett. 1996 Mar 15; 206(2-3):153-6. PMID: 8710174.
    Citations:    Fields:    Translation:AnimalsCells
  74. Kaufman MJ, Chiu TM, Mendelson JH, Woods BT, Teoh SK, Erös-Sarnyai M, Mercer G, Mello NK. Brain alcohol detectability increase with repeated administration in humans: a proton spectroscopy study. Magn Reson Med. 1996 Mar; 35(3):435-40. PMID: 8699957.
    Citations: 6     Fields:    Translation:Humans
  75. Kaufman MJ, Levin JM, Christensen JD, Renshaw PF. Magnetic Resonance Studies of Substance Abuse. Semin Clin Neuropsychiatry. 1996 Jan; 1(1):61-75. PMID: 10229784.
    Citations:    Fields:    
  76. Levin JM, Kaufman MJ, Ross MH, Mendelson JH, Maas LC, Cohen BM, Renshaw PF. Sequential dynamic susceptibility contrast MR experiments in human brain: residual contrast agent effect, steady state, and hemodynamic perturbation. Magn Reson Med. 1995 Nov; 34(5):655-63. PMID: 8544685.
    Citations: 13     Fields:    Translation:Humans
  77. Levin JM, Kaufman MJ. Functional studies in substance abuse: imaging and beyond. J Nucl Med. 1995 Jul; 36(7):1298-300. PMID: 7790959.
    Citations:    Fields:    Translation:HumansAnimals
  78. Kaufman MJ, Hartig PR, Hoffman BJ. Serotonin 5-HT2C receptor stimulates cyclic GMP formation in choroid plexus. J Neurochem. 1995 Jan; 64(1):199-205. PMID: 7798914.
    Citations: 6     Fields:    Translation:Animals
  79. Madras BK, Kaufman MJ. Cocaine accumulates in dopamine-rich regions of primate brain after i.v. administration: comparison with mazindol distribution. Synapse. 1994 Nov; 18(3):261-75. PMID: 7855738.
    Citations: 4     Fields:    Translation:Animals
  80. Kaufman MJ, Chiu TM, Mendelson JH, Woods BT, Mello NK, Lukas SE, Fivel PA, Wighton LG. In vivo proton magnetic resonance spectroscopy of alcohol in rhesus monkey brain. Magn Reson Imaging. 1994; 12(8):1245-53. PMID: 7854030.
    Citations: 6     Fields:    Translation:Animals
  81. Kaufman MJ, Madras BK. [3H]CFT ([3H]WIN 35,428) accumulation in dopamine regions of monkey brain: comparison of a mature and an aged monkey. Brain Res. 1993 May 21; 611(2):322-5. PMID: 8334525.
    Citations: 1     Fields:    Translation:Animals
  82. Kaufman MJ, Madras BK. Distribution of cocaine recognition sites in monkey brain: II. Ex vivo autoradiography with [3H]CFT and [125I]RTI-55. Synapse. 1992 Oct; 12(2):99-111. PMID: 1481136.
    Citations: 3     Fields:    Translation:AnimalsCells
  83. Kaufman MJ, Spealman RD, Madras BK. Distribution of cocaine recognition sites in monkey brain: I. In vitro autoradiography with [3H]CFT. Synapse. 1991 Nov; 9(3):177-87. PMID: 1776130.
    Citations: 9     Fields:    Translation:AnimalsCells
  84. Kaufman MJ, Madras BK. Severe depletion of cocaine recognition sites associated with the dopamine transporter in Parkinson's-diseased striatum. Synapse. 1991 Sep; 9(1):43-9. PMID: 1796351.
    Citations: 29     Fields:    Translation:Humans
  85. Baumgartner RA, Wills-Karp M, Kaufman MJ, Munakata M, Hirshman C. Serotonin induces constriction and relaxation of the guinea pig airway. J Pharmacol Exp Ther. 1990 Oct; 255(1):165-73. PMID: 1976797.
    Citations: 7     Fields:    Translation:Animals
  86. Hartig PR, Hoffman BJ, Kaufman MJ, Hirata F. The 5-HT1C receptor. Ann N Y Acad Sci. 1990; 600:149-66; discussion 166-7. PMID: 2252307.
    Citations: 8     Fields:    Translation:AnimalsCells
  87. Canfield DR, Spealman RD, Kaufman MJ, Madras BK. Autoradiographic localization of cocaine binding sites by [3H]CFT ([3H]WIN 35,428) in the monkey brain. Synapse. 1990; 6(2):189-95. PMID: 2237780.
    Citations: 9     Fields:    Translation:AnimalsCells
  88. Young JS, Upchurch MB, Kaufman MJ, Fechter LD. Carbon monoxide exposure potentiates high-frequency auditory threshold shifts induced by noise. Hear Res. 1987; 26(1):37-43. PMID: 3558142.
    Citations: 6     Fields:    Translation:AnimalsPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.