Harvard Catalyst Profiles

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David Steven Pellman, M.D.

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Department
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Other Positions
Title
Institution
Department

Mentoring
Defining the mechanism underlying micronuclei-mediated mutagenesis in cancer
Summer, 06/16/14 - 08/01/14

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13CA177028 (PELLMAN, DAVID S) May 1, 2013 - Apr 30, 2014
    NIH/NCI
    2013 Cell Growth and Proliferation GRC/GRS
    Role: Principal Investigator
  2. R37GM061345 (PELLMAN, DAVID S) Jul 1, 2000 - Jul 31, 2019
    NIH/NIGMS
    Cell Cycle Control of the Cytoskeleton
    Role: Principal Investigator
  3. R01GM061345 (PELLMAN, DAVID S) Jul 1, 2000 - Jul 31, 2013
    NIH/NIGMS
    Cell Cycle Control of the Cytoskeleton
    Role: Principal Investigator
  4. R01CA213404 (PELLMAN, DAVID S) May 1, 1997 - Nov 30, 2021
    NIH/NCI
    Polyploidy, aneuploidy, and genome stability
    Role: Principal Investigator
  5. R01GM083299 (PELLMAN, DAVID S) May 1, 1997 - May 31, 2016
    NIH/NIGMS
    Polyploidy, aneuploidy and genome stability
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Deng L, Wu RA, Sonneville R, Kochenova OV, Labib K, Pellman D, Walter JC. Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements. Mol Cell. 2019 03 07; 73(5):915-929.e6. PMID: 30849395.
    Citations:    
  2. Jiao AL, Perales R, Umbreit NT, Haswell JR, Piper ME, Adams BD, Pellman D, Kennedy S, Slack FJ. Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor. RNA. 2019 03; 25(3):352-363. PMID: 30538148.
    Citations:    Fields:    
  3. Mowery CT, Reyes JM, Cabal-Hierro L, Higby KJ, Karlin KL, Wang JH, Kimmerling RJ, Cejas P, Lim K, Li H, Furusawa T, Long HW, Pellman D, Chapuy B, Bustin M, Manalis SR, Westbrook TF, Lin CY, Lane AA. Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression. Cell Rep. 2018 Nov 13; 25(7):1898-1911.e5. PMID: 30428356.
    Citations:    Fields:    
  4. Witwicki RM, Ekram MB, Qiu X, Janiszewska M, Shu S, Kwon M, Trinh A, Frias E, Ramadan N, Hoffman G, Yu K, Xie Y, McAllister G, McDonald R, Golji J, Schlabach M, deWeck A, Keen N, Chan HM, Ruddy D, Rejtar T, Sovath S, Silver S, Sellers WR, Jagani Z, Hogarty MD, Roberts C, Brown M, Stegmaier K, Long H, Shivdasani RA, Pellman D, Polyak K. TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer. Cell Rep. 2018 Oct 30; 25(5):1255-1267.e5. PMID: 30380416.
    Citations:    Fields:    
  5. Oser MG, Fonseca R, Chakraborty AA, Brough R, Spektor A, Jennings RB, Flaifel A, Novak JS, Gulati A, Buss E, Younger ST, McBrayer SK, Cowley GS, Bonal DM, Nguyen QD, Brulle-Soumare L, Taylor P, Cairo S, Ryan CJ, Pease EJ, Maratea K, Travers J, Root DE, Signoretti S, Pellman D, Ashton S, Lord CJ, Barry ST, Kaelin WG. Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival. Cancer Discov. 2019 02; 9(2):230-247. PMID: 30373918.
    Citations:    Fields:    
  6. Liu S, Kwon M, Mannino M, Yang N, Renda F, Khodjakov A, Pellman D. Nuclear envelope assembly defects link mitotic errors to chromothripsis. Nature. 2018 09; 561(7724):551-555. PMID: 30232450.
    Citations: 1     Fields:    
  7. Johnson WL, Xie KT, Kwon M, Liu S, Pellman D. How the Genome Folds, Divides, Lives, and Dies. Cold Spring Harb Symp Quant Biol. 2017; 82:349-360. PMID: 29802151.
    Citations:    Fields:    
  8. Marteil G, Guerrero A, Vieira AF, de Almeida BP, Machado P, Mendonça S, Mesquita M, Villarreal B, Fonseca I, Francia ME, Dores K, Martins NP, Jana SC, Tranfield EM, Barbosa-Morais NL, Paredes J, Pellman D, Godinho SA, Bettencourt-Dias M. Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation. Nat Commun. 2018 03 28; 9(1):1258. PMID: 29593297.
    Citations: 2     Fields:    Translation:HumansCells
  9. Spektor A, Umbreit NT, Pellman D. Cell Biology: When Your Own Chromosomes Act like Foreign DNA. Curr Biol. 2017 Nov 20; 27(22):R1228-R1231. PMID: 29161564.
    Citations:    Fields:    
  10. Umbreit NT, Pellman D. Cancer biology: Genome jail-break triggers lockdown. Nature. 2017 10 19; 550(7676):340-341. PMID: 28976957.
    Citations:    Fields:    Translation:Humans
  11. Arellano-Santoyo H, Geyer EA, Stokasimov E, Chen GY, Su X, Hancock W, Rice LM, Pellman D. A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity. Dev Cell. 2017 07 10; 42(1):37-51.e8. PMID: 28697331.
    Citations: 6     Fields:    Translation:AnimalsCells
  12. Li H, Mar BG, Zhang H, Puram RV, Vazquez F, Weir BA, Hahn WC, Ebert B, Pellman D. The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia. Blood. 2017 01 26; 129(4):497-508. PMID: 27756750.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  13. Zhang CZ, Pellman D. From Mutational Mechanisms in Single Cells to Mutational Patterns in Cancer Genomes. Cold Spring Harb Symp Quant Biol. 2015; 80:117-37. PMID: 26968629.
    Citations: 1     Fields:    Translation:HumansAnimals
  14. Gordon DJ, Motwani M, Pellman D. Modeling the initiation of Ewing sarcoma tumorigenesis in differentiating human embryonic stem cells. Oncogene. 2016 06 16; 35(24):3092-102. PMID: 26455317.
    Citations: 4     Fields:    Translation:HumansCells
  15. Leibowitz ML, Zhang CZ, Pellman D. Chromothripsis: A New Mechanism for Rapid Karyotype Evolution. Annu Rev Genet. 2015; 49:183-211. PMID: 26442848.
    Citations: 36     Fields:    Translation:HumansCells
  16. Kwon M, Bagonis M, Danuser G, Pellman D. Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin Clouds. Dev Cell. 2015 Aug 10; 34(3):323-37. PMID: 26235048.
    Citations: 19     Fields:    Translation:HumansCells
  17. Zhang CZ, Spektor A, Cornils H, Francis JM, Jackson EK, Liu S, Meyerson M, Pellman D. Chromothripsis from DNA damage in micronuclei. Nature. 2015 Jun 11; 522(7555):179-84. PMID: 26017310.
    Citations: 143     Fields:    Translation:HumansCells
  18. Selmecki AM, Maruvka YE, Richmond PA, Guillet M, Shoresh N, Sorenson AL, De S, Kishony R, Michor F, Dowell R, Pellman D. Polyploidy can drive rapid adaptation in yeast. Nature. 2015 Mar 19; 519(7543):349-52. PMID: 25731168.
    Citations: 60     Fields:    Translation:AnimalsCells
  19. Cowley GS, Weir BA, Vazquez F, Tamayo P, Scott JA, Rusin S, East-Seletsky A, Ali LD, Gerath WF, Pantel SE, Lizotte PH, Jiang G, Hsiao J, Tsherniak A, Dwinell E, Aoyama S, Okamoto M, Harrington W, Gelfand E, Green TM, Tomko MJ, Gopal S, Wong TC, Li H, Howell S, Stransky N, Liefeld T, Jang D, Bistline J, Meyers BH, Armstrong SA, Anderson KC, Stegmaier K, Reich M, Pellman D, Boehm JS, Mesirov JP, Golub TR, Root DE, Hahn WC. Erratum: Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Sci Data. 2014; 1:140044. PMID: 25982629; PMCID: PMC4411007.
    Citations:    
  20. Cowley GS, Weir BA, Vazquez F, Tamayo P, Scott JA, Rusin S, East-Seletsky A, Ali LD, Gerath WF, Pantel SE, Lizotte PH, Jiang G, Hsiao J, Tsherniak A, Dwinell E, Aoyama S, Okamoto M, Harrington W, Gelfand E, Green TM, Tomko MJ, Gopal S, Wong TC, Wong TC, Li H, Howell S, Stransky N, Liefeld T, Jang D, Bistline J, Hill Meyers B, Armstrong SA, Anderson KC, Stegmaier K, Reich M, Pellman D, Boehm JS, Mesirov JP, Golub TR, Root DE, Hahn WC. Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Sci Data. 2014; 1:140035. PMID: 25984343.
    Citations: 89     Fields:    Translation:HumansCells
  21. Varetti G, Pellman D, Gordon DJ. Aurea mediocritas: the importance of a balanced genome. Cold Spring Harb Perspect Biol. 2014 Sep 18; 6(11):a015842. PMID: 25237130.
    Citations: 5     Fields:    Translation:Cells
  22. Godinho SA, Pellman D. Causes and consequences of centrosome abnormalities in cancer. Philos Trans R Soc Lond B Biol Sci. 2014 Sep 05; 369(1650). PMID: 25047621.
    Citations: 62     Fields:    Translation:HumansCells
  23. Ganem NJ, Cornils H, Chiu SY, O'Rourke KP, Arnaud J, Yimlamai D, Théry M, Camargo FD, Pellman D. Cytokinesis failure triggers hippo tumor suppressor pathway activation. Cell. 2014 Aug 14; 158(4):833-848. PMID: 25126788.
    Citations: 96     Fields:    Translation:HumansCells
  24. Lane AA, Chapuy B, Lin CY, Tivey T, Li H, Townsend EC, van Bodegom D, Day TA, Wu SC, Liu H, Yoda A, Alexe G, Schinzel AC, Sullivan TJ, Malinge S, Taylor JE, Stegmaier K, Jaffe JD, Bustin M, te Kronnie G, Izraeli S, Harris MH, Stevenson KE, Neuberg D, Silverman LB, Sallan SE, Bradner JE, Hahn WC, Crispino JD, Pellman D, Weinstock DM. Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. Nat Genet. 2014 Jun; 46(6):618-23. PMID: 24747640.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  25. Godinho SA, Picone R, Burute M, Dagher R, Su Y, Leung CT, Polyak K, Brugge JS, Théry M, Pellman D. Oncogene-like induction of cellular invasion from centrosome amplification. Nature. 2014 Jun 05; 510(7503):167-71. PMID: 24739973.
    Citations: 81     Fields:    Translation:HumansCells
  26. Lee DH, Acharya SS, Kwon M, Drane P, Guan Y, Adelmant G, Kalev P, Shah J, Pellman D, Marto JA, Chowdhury D. Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks. Mol Cell. 2014 May 08; 54(3):512-25. PMID: 24703952.
    Citations: 30     Fields:    Translation:HumansCells
  27. Zhang CZ, Leibowitz ML, Pellman D. Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements. Genes Dev. 2013 Dec 01; 27(23):2513-30. PMID: 24298051.
    Citations: 63     Fields:    Translation:Humans
  28. Atkins BD, Yoshida S, Saito K, Wu CF, Lew DJ, Pellman D. Inhibition of Cdc42 during mitotic exit is required for cytokinesis. J Cell Biol. 2013 Jul 22; 202(2):231-40. PMID: 23878274.
    Citations: 23     Fields:    Translation:AnimalsCells
  29. Su X, Arellano-Santoyo H, Portran D, Gaillard J, Vantard M, Thery M, Pellman D. Microtubule-sliding activity of a kinesin-8 promotes spindle assembly and spindle-length control. Nat Cell Biol. 2013 Aug; 15(8):948-57. PMID: 23851487.
    Citations: 31     Fields:    Translation:Cells
  30. Ganem NJ, Pellman D. Linking abnormal mitosis to the acquisition of DNA damage. J Cell Biol. 2012 Dec 10; 199(6):871-81. PMID: 23229895.
    Citations: 61     Fields:    Translation:HumansAnimals
  31. Su X, Ohi R, Pellman D. Move in for the kill: motile microtubule regulators. Trends Cell Biol. 2012 Nov; 22(11):567-75. PMID: 22959403.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  32. Buttery SM, Kono K, Stokasimov E, Pellman D. Regulation of the formin Bnr1 by septins anda MARK/Par1-family septin-associated kinase. Mol Biol Cell. 2012 Oct; 23(20):4041-53. PMID: 22918953.
    Citations: 15     Fields:    Translation:AnimalsCells
  33. Kono K, Saeki Y, Yoshida S, Tanaka K, Pellman D. Proteasomal degradation resolves competition between cell polarization and cellular wound healing. Cell. 2012 Jul 06; 150(1):151-64. PMID: 22727045.
    Citations: 34     Fields:    Translation:AnimalsCells
  34. Varetti G, Pellman D. "Two" much of a good thing: telomere damage-induced genome doubling drives tumorigenesis. Cancer Cell. 2012 Jun 12; 21(6):712-4. PMID: 22698395.
    Citations: 2     Fields:    
  35. Carter SL, Cibulskis K, Helman E, McKenna A, Shen H, Zack T, Laird PW, Onofrio RC, Winckler W, Weir BA, Beroukhim R, Pellman D, Levine DA, Lander ES, Meyerson M, Getz G. Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol. 2012 May; 30(5):413-21. PMID: 22544022.
    Citations: 397     Fields:    Translation:HumansCells
  36. Gordon DJ, Resio B, Pellman D. Causes and consequences of aneuploidy in cancer. Nat Rev Genet. 2012 Jan 24; 13(3):189-203. PMID: 22269907.
    Citations: 234     Fields:    Translation:Humans
  37. Crasta K, Ganem NJ, Dagher R, Lantermann AB, Ivanova EV, Pan Y, Nezi L, Protopopov A, Chowdhury D, Pellman D. DNA breaks and chromosome pulverization from errors in mitosis. Nature. 2012 Jan 18; 482(7383):53-8. PMID: 22258507.
    Citations: 275     Fields:    Translation:HumansCells
  38. Su X, Qiu W, Gupta ML, Pereira-Leal JB, Reck-Peterson SL, Pellman D. Mechanisms underlying the dual-mode regulation of microtubule dynamics by Kip3/kinesin-8. Mol Cell. 2011 Sep 02; 43(5):751-63. PMID: 21884976.
    Citations: 52     Fields:    Translation:HumansCells
  39. Bettencourt-Dias M, Hildebrandt F, Pellman D, Woods G, Godinho SA. Centrosomes and cilia in human disease. Trends Genet. 2011 Aug; 27(8):307-15. PMID: 21680046.
    Citations: 117     Fields:    Translation:HumansCells
  40. Storchová Z, Becker JS, Talarek N, Kögelsberger S, Pellman D. Bub1, Sgo1, and Mps1 mediate a distinct pathway for chromosome biorientation in budding yeast. Mol Biol Cell. 2011 May; 22(9):1473-85. PMID: 21389114.
    Citations: 18     Fields:    Translation:AnimalsCells
  41. Meyerson M, Pellman D. Cancer genomes evolve by pulverizing single chromosomes. Cell. 2011 Jan 07; 144(1):9-10. PMID: 21215363.
    Citations: 26     Fields:    
  42. Breuer M, Kolano A, Kwon M, Li CC, Tsai TF, Pellman D, Brunet S, Verlhac MH. HURP permits MTOC sorting for robust meiotic spindle bipolarity, similar to extra centrosome clustering in cancer cells. J Cell Biol. 2010 Dec 27; 191(7):1251-60. PMID: 21173113.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  43. Vinciguerra P, Godinho SA, Parmar K, Pellman D, D'Andrea AD. Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells. J Clin Invest. 2010 Nov; 120(11):3834-42. PMID: 20921626.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  44. Pellman D. David Pellman: Grasping the geometry of cancer. Interviewed by Caitlin Sedwick. J Cell Biol. 2010 Jul 12; 190(1):4-5. PMID: 20624895.
    Citations:    Fields:    Translation:HumansAnimalsCells
  45. Kwiatkowski N, Jelluma N, Filippakopoulos P, Soundararajan M, Manak MS, Kwon M, Choi HG, Sim T, Deveraux QL, Rottmann S, Pellman D, Shah JV, Kops GJ, Knapp S, Gray NS. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol. 2010 May; 6(5):359-68. PMID: 20383151.
    Citations: 91     Fields:    
  46. Tischfield MA, Baris HN, Wu C, Rudolph G, Van Maldergem L, He W, Chan WM, Andrews C, Demer JL, Robertson RL, Mackey DA, Ruddle JB, Bird TD, Gottlob I, Pieh C, Traboulsi EI, Pomeroy SL, Hunter DG, Soul JS, Newlin A, Sabol LJ, Doherty EJ, de Uzcátegui CE, de Uzcátegui N, Collins ML, Sener EC, Wabbels B, Hellebrand H, Meitinger T, de Berardinis T, Magli A, Schiavi C, Pastore-Trossello M, Koc F, Wong AM, Levin AV, Geraghty MT, Descartes M, Flaherty M, Jamieson RV, Møller HU, Meuthen I, Callen DF, Kerwin J, Lindsay S, Meindl A, Gupta ML, Pellman D, Engle EC. Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell. 2010 Jan 08; 140(1):74-87. PMID: 20074521.
    Citations: 157     Fields:    Translation:HumansAnimalsCells
  47. Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K, Heinrichs S, Ganem NJ, Ho KW, Neuberg DS, Johnston A, Ahn Y, Kutok JL, Hromas R, Wray J, Lee C, Murphy C, Radtke I, Downing JR, Fleming MD, MacConaill LE, Amatruda JF, Gutierrez A, Galinsky I, Stone RM, Ross EA, Pellman DS, Kanki JP, Look AT. Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression. Mol Cell Biol. 2009 Nov; 29(21):5911-22. PMID: 19704007.
    Citations: 14     Fields:    Translation:AnimalsCells
  48. Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature. 2009 Jul 09; 460(7252):278-82. PMID: 19506557.
    Citations: 491     Fields:    Translation:HumansCells
  49. Godinho SA, Kwon M, Pellman D. Centrosomes and cancer: how cancer cells divide with too many centrosomes. Cancer Metastasis Rev. 2009 Jun; 28(1-2):85-98. PMID: 19156503.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  50. Yoshida S, Bartolini S, Pellman D. Mechanisms for concentrating Rho1 during cytokinesis. Genes Dev. 2009 Apr 01; 23(7):810-23. PMID: 19339687.
    Citations: 45     Fields:    Translation:AnimalsCells
  51. Chandhok NS, Pellman D. A little CIN may cost a lot: revisiting aneuploidy and cancer. Curr Opin Genet Dev. 2009 Feb; 19(1):74-81. PMID: 19195877.
    Citations: 30     Fields:    
  52. Atkins BD, Yoshida S, Pellman D. Symmetry breaking: scaffold plays matchmaker for polarity signaling proteins. Curr Biol. 2008 Dec 23; 18(24):R1130-2. PMID: 19108767.
    Citations: 1     Fields:    Translation:AnimalsCells
  53. Kwon M, Godinho SA, Chandhok NS, Ganem NJ, Azioune A, Thery M, Pellman D. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev. 2008 Aug 15; 22(16):2189-203. PMID: 18662975.
    Citations: 214     Fields:    Translation:AnimalsCells
  54. Austin KM, Gupta ML, Coats SA, Tulpule A, Mostoslavsky G, Balazs AB, Mulligan RC, Daley G, Pellman D, Shimamura A. Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome. J Clin Invest. 2008 Apr; 118(4):1511-8. PMID: 18324336.
    Citations: 30     Fields:    Translation:HumansCells
  55. Kono K, Nogami S, Abe M, Nishizawa M, Morishita S, Pellman D, Ohya Y. G1/S cyclin-dependent kinase regulates small GTPase Rho1p through phosphorylation of RhoGEF Tus1p in Saccharomyces cerevisiae. Mol Biol Cell. 2008 Apr; 19(4):1763-71. PMID: 18256282.
    Citations: 17     Fields:    Translation:AnimalsCells
  56. Yoshida S, Pellman D. Plugging the GAP between cell polarity and cell cycle. EMBO Rep. 2008 Jan; 9(1):39-41. PMID: 18174895.
    Citations: 3     Fields:    Translation:Animals
  57. Ganem NJ, Pellman D. Limiting the proliferation of polyploid cells. Cell. 2007 Nov 02; 131(3):437-40. PMID: 17981108.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  58. Ceol CJ, Pellman D, Zon LI. APC and colon cancer: two hits for one. Nat Med. 2007 Nov; 13(11):1286-7. PMID: 17987022.
    Citations: 5     Fields:    Translation:HumansAnimals
  59. Schüller U, Zhao Q, Godinho SA, Heine VM, Medema RH, Pellman D, Rowitch DH. Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors. Mol Cell Biol. 2007 Dec; 27(23):8259-70. PMID: 17893320.
    Citations: 42     Fields:    Translation:AnimalsCells
  60. Jallepalli PV, Pellman D. Cell biology. Aneuploidy in the balance. Science. 2007 Aug 17; 317(5840):904-5. PMID: 17702931.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  61. Buttery SM, Yoshida S, Pellman D. Yeast formins Bni1 and Bnr1 utilize different modes of cortical interaction during the assembly of actin cables. Mol Biol Cell. 2007 May; 18(5):1826-38. PMID: 17344480.
    Citations: 53     Fields:    Translation:Animals
  62. Pellman D. Cell biology: aneuploidy and cancer. Nature. 2007 Mar 01; 446(7131):38-9. PMID: 17330036.
    Citations: 33     Fields:    Translation:Animals
  63. Ganem NJ, Storchova Z, Pellman D. Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev. 2007 Apr; 17(2):157-62. PMID: 17324569.
    Citations: 246     Fields:    Translation:HumansCells
  64. Storchová Z, Breneman A, Cande J, Dunn J, Burbank K, O'Toole E, Pellman D. Genome-wide genetic analysis of polyploidy in yeast. Nature. 2006 Oct 05; 443(7111):541-7. PMID: 17024086.
    Citations: 112     Fields:    Translation:AnimalsCells
  65. Gupta ML, Carvalho P, Roof DM, Pellman D. Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle. Nat Cell Biol. 2006 Sep; 8(9):913-23. PMID: 16906148.
    Citations: 123     Fields:    Translation:AnimalsCells
  66. Yoshida S, Kono K, Lowery DM, Bartolini S, Yaffe MB, Ohya Y, Pellman D. Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science. 2006 Jul 07; 313(5783):108-11. PMID: 16763112.
    Citations: 69     Fields:    Translation:AnimalsCells
  67. Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, Pellman D. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature. 2005 Oct 13; 437(7061):1043-7. PMID: 16222300.
    Citations: 349     Fields:    Translation:AnimalsCells
  68. Yoshida S, Guillet M, Pellman D. MEN signaling: daughter bound pole must escape her mother to be fully active. Dev Cell. 2005 Aug; 9(2):168-70. PMID: 16054023.
    Citations: 2     Fields:    Translation:AnimalsCells
  69. Carvalho P, Pellman D. Mitotic spindle: laser microsurgery in yeast cells. Curr Biol. 2004 Sep 21; 14(18):R748-50. PMID: 15380083.
    Citations: 2     Fields:    Translation:AnimalsCells
  70. Andalis AA, Storchova Z, Styles C, Galitski T, Pellman D, Fink GR. Defects arising from whole-genome duplications in Saccharomyces cerevisiae. Genetics. 2004 Jul; 167(3):1109-21. PMID: 15280227.
    Citations: 28     Fields:    Translation:Animals
  71. Carvalho P, Gupta ML, Hoyt MA, Pellman D. Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation. Dev Cell. 2004 Jun; 6(6):815-29. PMID: 15177030.
    Citations: 73     Fields:    Translation:AnimalsCells
  72. Xu Y, Moseley JB, Sagot I, Poy F, Pellman D, Goode BL, Eck MJ. Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture. Cell. 2004 Mar 05; 116(5):711-23. PMID: 15006353.
    Citations: 137     Fields:    Translation:Cells
  73. Molk JN, Schuyler SC, Liu JY, Evans JG, Salmon ED, Pellman D, Bloom K. The differential roles of budding yeast Tem1p, Cdc15p, and Bub2p protein dynamics in mitotic exit. Mol Biol Cell. 2004 Apr; 15(4):1519-32. PMID: 14718561.
    Citations: 45     Fields:    Translation:AnimalsCells
  74. Storchova Z, Pellman D. From polyploidy to aneuploidy, genome instability and cancer. Nat Rev Mol Cell Biol. 2004 Jan; 5(1):45-54. PMID: 14708009.
    Citations: 216     Fields:    Translation:HumansAnimals
  75. Moseley JB, Sagot I, Manning AL, Xu Y, Eck MJ, Pellman D, Goode BL. A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilin. Mol Biol Cell. 2004 Feb; 15(2):896-907. PMID: 14657240.
    Citations: 111     Fields:    Translation:AnimalsCells
  76. Carvalho P, Tirnauer JS, Pellman D. Surfing on microtubule ends. Trends Cell Biol. 2003 May; 13(5):229-37. PMID: 12742166.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  77. Chestukhin A, Pfeffer C, Milligan S, DeCaprio JA, Pellman D. Processing, localization, and requirement of human separase for normal anaphase progression. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4574-9. PMID: 12672959.
    Citations: 35     Fields:    Translation:HumansCells
  78. Sheeman B, Carvalho P, Sagot I, Geiser J, Kho D, Hoyt MA, Pellman D. Determinants of S. cerevisiae dynein localization and activation: implications for the mechanism of spindle positioning. Curr Biol. 2003 Mar 04; 13(5):364-72. PMID: 12620184.
    Citations: 106     Fields:    Translation:AnimalsCells
  79. Schuyler SC, Liu JY, Pellman D. The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins. J Cell Biol. 2003 Feb 17; 160(4):517-28. PMID: 12591913.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  80. Leader B, Lim H, Carabatsos MJ, Harrington A, Ecsedy J, Pellman D, Maas R, Leder P. Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes. Nat Cell Biol. 2002 Dec; 4(12):921-8. PMID: 12447394.
    Citations: 84     Fields:    Translation:AnimalsCells
  81. Sagot I, Rodal AA, Moseley J, Goode BL, Pellman D. An actin nucleation mechanism mediated by Bni1 and profilin. Nat Cell Biol. 2002 Aug; 4(8):626-31. PMID: 12134165.
    Citations: 169     Fields:    Translation:AnimalsCells
  82. Schuyler SC, Pellman D. Analysis of the size and shape of protein complexes from yeast. Methods Enzymol. 2002; 351:150-68. PMID: 12073341.
    Citations: 11     Fields:    Translation:Animals
  83. Sagot I, Klee SK, Pellman D. Yeast formins regulate cell polarity by controlling the assembly of actin cables. Nat Cell Biol. 2002 Jan; 4(1):42-50. PMID: 11740491.
    Citations: 146     Fields:    Translation:AnimalsCells
  84. Lin H, de Carvalho P, Kho D, Tai CY, Pierre P, Fink GR, Pellman D. Polyploids require Bik1 for kinetochore-microtubule attachment. J Cell Biol. 2001 Dec 24; 155(7):1173-84. PMID: 11756471.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  85. Yarm F, Sagot I, Pellman D. The social life of actin and microtubules: interaction versus cooperation. Curr Opin Microbiol. 2001 Dec; 4(6):696-702. PMID: 11731322.
    Citations: 7     Fields:    Translation:AnimalsCells
  86. Lechler T, Jonsdottir GA, Klee SK, Pellman D, Li R. A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast. J Cell Biol. 2001 Oct 15; 155(2):261-70. PMID: 11604421.
    Citations: 35     Fields:    Translation:AnimalsCells
  87. Pellman D, Christman MF. Separase anxiety: dissolving the sister bond and more. Nat Cell Biol. 2001 Sep; 3(9):E207-9. PMID: 11533673.
    Citations: 3     Fields:    Translation:AnimalsCells
  88. Huang JN, Park I, Ellingson E, Littlepage LE, Pellman D. Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20p. J Cell Biol. 2001 Jul 09; 154(1):85-94. PMID: 11448992.
    Citations: 46     Fields:    Translation:AnimalsCells
  89. Schuyler SC, Pellman D. Microtubule "plus-end-tracking proteins": The end is just the beginning. Cell. 2001 May 18; 105(4):421-4. PMID: 11371339.
    Citations: 122     Fields:    Translation:HumansAnimalsCells
  90. Pellman D. Cancer. A CINtillating new job for the APC tumor suppressor. Science. 2001 Mar 30; 291(5513):2555-6. PMID: 11286276.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  91. Jónsson ZO, Dhar SK, Narlikar GJ, Auty R, Wagle N, Pellman D, Pratt RE, Kingston R, Dutta A. Rvb1p and Rvb2p are essential components of a chromatin remodeling complex that regulates transcription of over 5% of yeast genes. J Biol Chem. 2001 May 11; 276(19):16279-88. PMID: 11278922.
    Citations: 39     Fields:    Translation:AnimalsCells
  92. Schuyler SC, Pellman D. Search, capture and signal: games microtubules and centrosomes play. J Cell Sci. 2001 Jan; 114(Pt 2):247-55. PMID: 11148127.
    Citations: 31     Fields:    Translation:AnimalsCells
  93. Lee L, Tirnauer JS, Li J, Schuyler SC, Liu JY, Pellman D. Positioning of the mitotic spindle by a cortical-microtubule capture mechanism. Science. 2000 Mar 24; 287(5461):2260-2. PMID: 10731147.
    Citations: 93     Fields:    Translation:AnimalsCells
  94. Tirnauer JS, O'Toole E, Berrueta L, Bierer BE, Pellman D. Yeast Bim1p promotes the G1-specific dynamics of microtubules. J Cell Biol. 1999 May 31; 145(5):993-1007. PMID: 10352017.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  95. Berrueta L, Tirnauer JS, Schuyler SC, Pellman D, Bierer BE. The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain. Curr Biol. 1999 Apr 22; 9(8):425-8. PMID: 10226031.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  96. Lee L, Klee SK, Evangelista M, Boone C, Pellman D. Control of mitotic spindle position by the Saccharomyces cerevisiae formin Bni1p. J Cell Biol. 1999 Mar 08; 144(5):947-61. PMID: 10085293.
    Citations: 63     Fields:    Translation:AnimalsCells
  97. Berrueta L, Kraeft SK, Tirnauer JS, Schuyler SC, Chen LB, Hill DE, Pellman D, Bierer BE. The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules. Proc Natl Acad Sci U S A. 1998 Sep 01; 95(18):10596-601. PMID: 9724749.
    Citations: 56     Fields:    Translation:AnimalsCells
  98. D'Andrea A, Pellman D. Deubiquitinating enzymes: a new class of biological regulators. Crit Rev Biochem Mol Biol. 1998; 33(5):337-52. PMID: 9827704.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  99. DeZwaan TM, Ellingson E, Pellman D, Roof DM. Kinesin-related KIP3 of Saccharomyces cerevisiae is required for a distinct step in nuclear migration. J Cell Biol. 1997 Sep 08; 138(5):1023-40. PMID: 9281581.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  100. Juang YL, Huang J, Peters JM, McLaughlin ME, Tai CY, Pellman D. APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle. Science. 1997 Feb 28; 275(5304):1311-4. PMID: 9036857.
    Citations: 117     Fields:    Translation:AnimalsCells
  101. Pellman D, Bagget M, Tu YH, Fink GR, Tu H. Two microtubule-associated proteins required for anaphase spindle movement in Saccharomyces cerevisiae. J Cell Biol. 1995 Sep; 130(6):1373-85. PMID: 7559759.
    Citations: 68     Fields:    Translation:AnimalsCells
  102. Loeb JD, Schlenstedt G, Pellman D, Kornitzer D, Silver PA, Fink GR. The yeast nuclear import receptor is required for mitosis. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):7647-51. PMID: 7644471.
    Citations: 68     Fields:    Translation:AnimalsCells
  103. Pellman D, McLaughlin ME, Fink GR. TATA-dependent and TATA-independent transcription at the HIS4 gene of yeast. Nature. 1990 Nov 01; 348(6296):82-5. PMID: 2234066.
    Citations: 15     Fields:    Translation:AnimalsCells
  104. Stoeckle MY, Sugano S, Hampe A, Vashistha A, Pellman D, Hanafusa H. 78-kilodalton glucose-regulated protein is induced in Rous sarcoma virus-transformed cells independently of glucose deprivation. Mol Cell Biol. 1988 Jul; 8(7):2675-80. PMID: 2841586.
    Citations: 16     Fields:    Translation:AnimalsCells
  105. Pellman D, Garber EA, Cross FR, Hanafusa H. Fine structural mapping of a critical NH2-terminal region of p60src. Proc Natl Acad Sci U S A. 1985 Mar; 82(6):1623-7. PMID: 2984663.
    Citations: 58     Fields:    Translation:Cells
  106. Pellman D, Garber EA, Cross FR, Hanafusa H. An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins. Nature. 1985 Mar 28-Apr 3; 314(6009):374-7. PMID: 3920530.
    Citations: 84     Fields:    Translation:AnimalsCells
  107. Cross FR, Garber EA, Pellman D, Hanafusa H. A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation. Mol Cell Biol. 1984 Sep; 4(9):1834-42. PMID: 6092942.
    Citations: 189     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.