Harvard Catalyst Profiles

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Sandeep Robert Datta, M.D., Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. RF1AG073625 (DATTA, SANDEEP R) Sep 15, 2021 - Aug 31, 2024
    Neurobehavioral phenotyping of AD model mice using Motion Sequencing
    Role: Principal Investigator
  2. R01NS114020 (SOLTESZ, IVAN) Sep 30, 2019 - Jun 30, 2024
    Automated Phenotyping in Epilepsy
    Role: Co-Principal Investigator
  3. U19NS113201 (SABATINI, BERNARDO L) Aug 15, 2019 - Jul 31, 2024
    Towards a unified framework for dopamine signaling in the striatum
    Role: Co-Principal Investigator
  4. U24NS109520 (DATTA, SANDEEP R) Apr 1, 2019 - Jan 31, 2025
    Motion Sequencing for All: pipelining, distribution and training to enable broad adoption of a next-generation platform for behavioral and neurobehavioral analysis
    Role: Principal Investigator
  5. R01DC016222 (DATTA, SANDEEP R) Apr 1, 2017 - Mar 31, 2022
    Characterizing the Functional Architecture of the Necklace Olfactory System
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Markowitz JE, Gillis WF, Jay M, Wood J, Harris RW, Cieszkowski R, Scott R, Brann D, Koveal D, Kula T, Weinreb C, Osman MAM, Pinto SR, Uchida N, Linderman SW, Sabatini BL, Datta SR. Spontaneous behaviour is structured by reinforcement without explicit reward. Nature. 2023 Jan 18. PMID: 36653449.
    Citations:    Fields:    
  2. Finlay JB, Brann DH, Abi Hachem R, Jang DW, Oliva AD, Ko T, Gupta R, Wellford SA, Moseman EA, Jang SS, Yan CH, Matsunami H, Tsukahara T, Datta SR, Goldstein BJ. Persistent post-COVID-19 smell loss is associated with immune cell infiltration and altered gene expression in olfactory epithelium. Sci Transl Med. 2022 12 21; 14(676):eadd0484. PMID: 36542694.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  3. Akiti K, Tsutsui-Kimura I, Xie Y, Mathis A, Markowitz JE, Anyoha R, Datta SR, Mathis MW, Uchida N, Watabe-Uchida M. Striatal dopamine explains novelty-induced behavioral dynamics and individual variability in threat prediction. Neuron. 2022 11 16; 110(22):3789-3804.e9. PMID: 36130595; PMCID: PMC9671833.
    Citations:    Fields:    Translation:Animals
  4. Zhang Z, Roberson DP, Kotoda M, Boivin B, Bohnslav JP, González-Cano R, Yarmolinsky DA, Turnes BL, Wimalasena NK, Neufeld SQ, Barrett LB, Quintão NLM, Fattori V, Taub DG, Wiltschko AB, Andrews NA, Harvey CD, Datta SR, Woolf CJ. Automated preclinical detection of mechanical pain hypersensitivity and analgesia. Pain. 2022 12 01; 163(12):2326-2336. PMID: 35543646; PMCID: PMC9649838.
    Citations:    Fields:    
  5. Mukharesh L, Bouffard MA, Fortin E, Brann DH, Datta SR, Prasad S, Chwalisz BK. Pseudotumor Cerebri Syndrome With COVID-19: A Case Series. J Neuroophthalmol. 2022 09 01; 42(3):e545-e547. PMID: 35482432.
    Citations:    Fields:    
  6. Finlay JB, Brann DH, Abi-Hachem R, Jang DW, Oliva AD, Ko T, Gupta R, Wellford SA, Moseman EA, Jang SS, Yan CH, Matusnami H, Tsukahara T, Datta SR, Goldstein BJ. Persistent post-COVID-19 smell loss is associated with inflammatory infiltration and altered olfactory epithelial gene expression. bioRxiv. 2022 Apr 18. PMID: 35478953; PMCID: PMC9044903.
  7. Tsukahara T, Brann DH, Pashkovski SL, Guitchounts G, Bozza T, Datta SR. A transcriptional rheostat couples past activity to future sensory responses. Cell. 2021 12 22; 184(26):6326-6343.e32. PMID: 34879231; PMCID: PMC8758202.
    Citations: 2     Fields:    Translation:AnimalsCells
  8. Favuzzi E, Huang S, Saldi GA, Binan L, Ibrahim LA, Fernández-Otero M, Cao Y, Zeine A, Sefah A, Zheng K, Xu Q, Khlestova E, Farhi SL, Bonneau R, Datta SR, Stevens B, Fishell G. GABA-receptive microglia selectively sculpt developing inhibitory circuits. Cell. 2021 Oct 28; 184(22):5686. PMID: 34715023; PMCID: PMC9122269.
    Citations: 3     Fields:    
  9. Kanwal JK, Coddington E, Frazer R, Limbania D, Turner G, Davila KJ, Givens MA, Williams V, Datta SR, Wasserman S. Internal State: Dynamic, Interconnected Communication Loops Distributed Across Body, Brain, and Time. Integr Comp Biol. 2021 10 04; 61(3):867-886. PMID: 34115114; PMCID: PMC8623242.
    Citations:    Fields:    Translation:Animals
  10. Favuzzi E, Huang S, Saldi GA, Binan L, Ibrahim LA, Fernández-Otero M, Cao Y, Zeine A, Sefah A, Zheng K, Xu Q, Khlestova E, Farhi SL, Bonneau R, Datta SR, Stevens B, Fishell G. GABA-receptive microglia selectively sculpt developing inhibitory circuits. Cell. 2021 07 22; 184(15):4048-4063.e32. PMID: 34233165; PMCID: PMC9122259.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  11. Chen J, Markowitz JE, Lilascharoen V, Taylor S, Sheurpukdi P, Keller JA, Jensen JR, Lim BK, Datta SR, Stowers L. Flexible scaling and persistence of social vocal communication. Nature. 2021 05; 593(7857):108-113. PMID: 33790464; PMCID: PMC9153763.
    Citations: 5     Fields:    Translation:AnimalsCells
  12. Dennis EJ, El Hady A, Michaiel A, Clemens A, Tervo DRG, Voigts J, Datta SR. Systems Neuroscience of Natural Behaviors in Rodents. J Neurosci. 2021 02 03; 41(5):911-919. PMID: 33443081.
    Citations: 3     Fields:    Translation:Animals
  13. Rudolph S, Guo C, Pashkovski SL, Osorno T, Gillis WF, Krauss JM, Nyitrai H, Flaquer I, El-Rifai M, Datta SR, Regehr WG. Cerebellum-Specific Deletion of the GABAA Receptor d Subunit Leads to Sex-Specific Disruption of Behavior. Cell Rep. 2020 11 03; 33(5):108338. PMID: 33147470; PMCID: PMC7700496.
    Citations: 9     Fields:    Translation:Animals
  14. Wiltschko AB, Tsukahara T, Zeine A, Anyoha R, Gillis WF, Markowitz JE, Peterson RE, Katon J, Johnson MJ, Datta SR. Revealing the structure of pharmacobehavioral space through motion sequencing. Nat Neurosci. 2020 11; 23(11):1433-1443. PMID: 32958923.
    Citations: 22     Fields:    Translation:Animals
  15. Pashkovski SL, Iurilli G, Brann D, Chicharro D, Drummey K, Franks KM, Panzeri S, Datta SR. Author Correction: Structure and flexibility in cortical representations of odour space. Nature. 2020 Aug; 584(7822):E38. PMID: 32782391.
    Citations:    Fields:    
  16. Brann DH, Tsukahara T, Weinreb C, Lipovsek M, Van den Berge K, Gong B, Chance R, Macaulay IC, Chou HJ, Fletcher RB, Das D, Street K, de Bezieux HR, Choi YG, Risso D, Dudoit S, Purdom E, Mill J, Hachem RA, Matsunami H, Logan DW, Goldstein BJ, Grubb MS, Ngai J, Datta SR. Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. Sci Adv. 2020 07 31; 6(31). PMID: 32937591.
    Citations: 373     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  17. Brann DH, Datta SR. Finding the Brain in the Nose. Annu Rev Neurosci. 2020 07 08; 43:277-295. PMID: 32640927.
    Citations: 4     Fields:    Translation:HumansAnimals
  18. Cooper KW, Brann DH, Farruggia MC, Bhutani S, Pellegrino R, Tsukahara T, Weinreb C, Joseph PV, Larson ED, Parma V, Albers MW, Barlow LA, Datta SR, Di Pizio A. COVID-19 and the Chemical Senses: Supporting Players Take Center Stage. Neuron. 2020 07 22; 107(2):219-233. PMID: 32640192.
    Citations: 96     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  19. Pashkovski SL, Iurilli G, Brann D, Chicharro D, Drummey K, Franks KM, Panzeri S, Datta SR. Structure and flexibility in cortical representations of odour space. Nature. 2020 07; 583(7815):253-258. PMID: 32612230.
    Citations: 25     Fields:    Translation:Animals
  20. Bloom ML, Johnston LB, Datta SR. Renewal and Differentiation of GCD Necklace Olfactory Sensory Neurons. Chem Senses. 2020 05 29; 45(5):333-346. PMID: 32333759.
    Citations: 1     Fields:    Translation:AnimalsCells
  21. Datta SR, Anderson DJ, Branson K, Perona P, Leifer A. Computational Neuroethology: A Call to Action. Neuron. 2019 10 09; 104(1):11-24. PMID: 31600508.
    Citations: 68     Fields:    Translation:Animals
  22. Markowitz JE, Datta SR. The striatum specifies the statistics of behavior. Neuropsychopharmacology. 2020 01; 45(1):222-223. PMID: 31467423.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  23. Datta SR. Q&A: Understanding the composition of behavior. BMC Biol. 2019 05 29; 17(1):44. PMID: 31142307; PMCID: PMC6542027.
    Citations: 10     Fields:    Translation:Animals
  24. Markowitz JE, Gillis WF, Beron CC, Neufeld SQ, Robertson K, Bhagat ND, Peterson RE, Peterson E, Hyun M, Linderman SW, Sabatini BL, Datta SR. The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection. Cell. 2018 06 28; 174(1):44-58.e17. PMID: 29779950.
    Citations: 86     Fields:    Translation:AnimalsCells
  25. Mao YT, Zhu JX, Hanamura K, Iurilli G, Datta SR, Dalva MB. Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase. Neuron. 2018 05 16; 98(4):767-782.e8. PMID: 29731254.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  26. Pisanello F, Mandelbaum G, Pisanello M, Oldenburg IA, Sileo L, Markowitz JE, Peterson RE, Della Patria A, Haynes TM, Emara MS, Spagnolo B, Datta SR, De Vittorio M, Sabatini BL. Dynamic illumination of spatially restricted or large brain volumes via a single tapered optical fiber. Nat Neurosci. 2017 Aug; 20(8):1180-1188. PMID: 28628101; PMCID: PMC5533215.
    Citations: 45     Fields:    Translation:AnimalsCells
  27. Gillis WF, Datta SR. Knowing where the nose is. BMC Biol. 2017 05 15; 15(1):42. PMID: 28506236; PMCID: PMC5432980.
    Citations:    Fields:    Translation:Animals
  28. Iurilli G, Datta SR. Population Coding in an Innately Relevant Olfactory Area. Neuron. 2017 Mar 08; 93(5):1180-1197.e7. PMID: 28238549.
    Citations: 34     Fields:    Translation:AnimalsCells
  29. Bear DM, Lassance JM, Hoekstra HE, Datta SR. The Evolving Neural and Genetic Architecture of Vertebrate Olfaction. Curr Biol. 2016 10 24; 26(20):R1039-R1049. PMID: 27780046; PMCID: PMC5104188.
    Citations: 39     Fields:    Translation:AnimalsCells
  30. Greer PL, Bear DM, Lassance JM, Bloom ML, Tsukahara T, Pashkovski SL, Masuda FK, Nowlan AC, Kirchner R, Hoekstra HE, Datta SR. A Family of non-GPCR Chemosensors Defines an Alternative Logic for Mammalian Olfaction. Cell. 2016 Jun 16; 165(7):1734-1748. PMID: 27238024.
    Citations: 49     Fields:    Translation:AnimalsCells
  31. Wiltschko AB, Johnson MJ, Iurilli G, Peterson RE, Katon JM, Pashkovski SL, Abraira VE, Adams RP, Datta SR. Mapping Sub-Second Structure in Mouse Behavior. Neuron. 2015 Dec 16; 88(6):1121-1135. PMID: 26687221.
    Citations: 178     Fields:    Translation:Animals
  32. Persson L, Witt RM, Galligan M, Greer PL, Eisner A, Pazyra-Murphy MF, Datta SR, Segal RA. Shh-proteoglycan interactions regulate maturation of olfactory glomerular circuitry. Dev Neurobiol. 2014 Dec; 74(12):1255-67. PMID: 24913191.
    Citations: 4     Fields:    Translation:AnimalsCells
  33. Giessel AJ, Datta SR. Olfactory maps, circuits and computations. Curr Opin Neurobiol. 2014 Feb; 24(1):120-32. PMID: 24492088.
    Citations: 34     Fields:    Translation:HumansAnimals
  34. Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D'Agostino R, Danial N, Datta SR, Kulik G. Behavioral stress accelerates prostate cancer development in mice. J Clin Invest. 2013 Feb; 123(2):874-86. PMID: 23348742; PMCID: PMC3561807.
    Citations: 116     Fields:    Translation:HumansAnimalsCells
  35. Datta SR, Patterson GH. Optical highlighter molecules in neurobiology. Curr Opin Neurobiol. 2012 Feb; 22(1):111-20. PMID: 22129781.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  36. Ferrero DM, Lemon JK, Fluegge D, Pashkovski SL, Korzan WJ, Datta SR, Spehr M, Fendt M, Liberles SD. Detection and avoidance of a carnivore odor by prey. Proc Natl Acad Sci U S A. 2011 Jul 05; 108(27):11235-40. PMID: 21690383.
    Citations: 130     Fields:    Translation:AnimalsCells
  37. Sosulski DL, Bloom ML, Cutforth T, Axel R, Datta SR. Distinct representations of olfactory information in different cortical centres. Nature. 2011 Apr 14; 472(7342):213-6. PMID: 21451525.
    Citations: 186     Fields:    Translation:AnimalsCells
  38. Ruta V, Datta SR, Vasconcelos ML, Freeland J, Looger LL, Axel R. A dimorphic pheromone circuit in Drosophila from sensory input to descending output. Nature. 2010 Dec 02; 468(7324):686-90. PMID: 21124455.
    Citations: 157     Fields:    Translation:AnimalsCells
  39. Datta SR, Vasconcelos ML, Ruta V, Luo S, Wong A, Demir E, Flores J, Balonze K, Dickson BJ, Axel R. The Drosophila pheromone cVA activates a sexually dimorphic neural circuit. Nature. 2008 Mar 27; 452(7186):473-7. PMID: 18305480.
    Citations: 158     Fields:    Translation:AnimalsCells
  40. Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 2008 Feb; 14(2):144-53. PMID: 18223655.
    Citations: 136     Fields:    Translation:HumansAnimalsCells
  41. Sastry KSR, Smith AJ, Karpova Y, Datta SR, Kulik G. Diverse antiapoptotic signaling pathways activated by vasoactive intestinal polypeptide, epidermal growth factor, and phosphatidylinositol 3-kinase in prostate cancer cells converge on BAD. J Biol Chem. 2006 Jul 28; 281(30):20891-20901. PMID: 16728406.
    Citations: 27     Fields:    Translation:HumansCells
  42. Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM, Datta SR, Greenberg ME, Licklider LJ, Lowell BB, Gygi SP, Korsmeyer SJ. BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature. 2003 Aug 21; 424(6951):952-6. PMID: 12931191.
    Citations: 231     Fields:    Translation:AnimalsCells
  43. Ranger AM, Zha J, Harada H, Datta SR, Danial NN, Gilmore AP, Kutok JL, Le Beau MM, Greenberg ME, Korsmeyer SJ. Bad-deficient mice develop diffuse large B cell lymphoma. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9324-9. PMID: 12876200; PMCID: PMC170917.
    Citations: 111     Fields:    Translation:AnimalsCells
  44. Datta SR, Ranger AM, Lin MZ, Sturgill JF, Ma YC, Cowan CW, Dikkes P, Korsmeyer SJ, Greenberg ME. Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell. 2002 Nov; 3(5):631-43. PMID: 12431371.
    Citations: 95     Fields:    Translation:AnimalsCells
  45. Humbert S, Bryson EA, Cordelières FP, Connors NC, Datta SR, Finkbeiner S, Greenberg ME, Saudou F. The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt. Dev Cell. 2002 Jun; 2(6):831-7. PMID: 12062094.
    Citations: 192     Fields:    Translation:HumansCells
  46. Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ, DiStefano PS, Chiang LW, Greenberg ME. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science. 2002 Apr 19; 296(5567):530-4. PMID: 11964479.
    Citations: 296     Fields:    Translation:HumansAnimalsCells
  47. Brunet A, Datta SR, Greenberg ME. Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr Opin Neurobiol. 2001 Jun; 11(3):297-305. PMID: 11399427.
    Citations: 413     Fields:    Translation:HumansAnimalsCells
  48. Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Dev. 1999 Nov 15; 13(22):2905-27. PMID: 10579998.
    Citations: 1120     Fields:    Translation:HumansAnimalsCells
  49. Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science. 1999 Nov 12; 286(5443):1358-62. PMID: 10558990.
    Citations: 542     Fields:    Translation:AnimalsCells
  50. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 1997 Oct 17; 91(2):231-41. PMID: 9346240.
    Citations: 1505     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.