Harvard Catalyst Profiles

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Kazue Takahashi, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI077081 (TAKAHASHI, KAZUE) Sep 25, 2007 - Aug 31, 2010
    NIH/NIAID
    Innate Immunity in the Clearance of Influenza A Virus Infected Apoptotic Cells
    Role: Principal Investigator
  2. U01AI074503 (TAKAHASHI, KAZUE) Sep 1, 2007 - Aug 31, 2013
    NIH/NIAID
    Development of novel immunotherapy for influenza virus infection
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Szabari MV, Takahashi K, Feng Y, Locascio JJ, Chao W, Carter EA, Vidal Melo MF, Musch G. Relation between Respiratory Mechanics, Inflammation, and Survival in Experimental Mechanical Ventilation. Am J Respir Cell Mol Biol. 2019 Feb; 60(2):179-188. PMID: 30199644.
    Citations:    Fields:    
  2. Verwer EE, Kavanagh TR, Mischler WJ, Feng Y, Takahashi K, Wang S, Shoup TM, Neelamegam R, Yang J, Guehl NJ, Ran C, Massefski W, Cui Y, El-Chemaly S, Sadow PM, Oldham WM, Kijewski MF, El Fakhri G, Normandin MD, Priolo C. [18F]Fluorocholine and [18F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM. Clin Cancer Res. 2018 Dec 01; 24(23):5925-5938. PMID: 30054282.
    Citations:    Fields:    
  3. Alpert NM, Guehl N, Ptaszek L, Pelletier-Galarneau M, Ruskin J, Mansour MC, Wooten D, Ma C, Takahashi K, Zhou Y, Shoup TM, Normandin MD, El Fakhri G. Quantitative in vivo mapping of myocardial mitochondrial membrane potential. PLoS One. 2018; 13(1):e0190968. PMID: 29338024.
    Citations: 2     Fields:    Translation:Animals
  4. White MR, Tripathi S, Verma A, Kingma P, Takahashi K, Jensenius J, Thiel S, Wang G, Crouch EC, Hartshorn KL. Collectins, H-ficolin and LL-37 reduce influence viral replication in human monocytes and modulate virus-induced cytokine production. Innate Immun. 2017 01; 23(1):77-88. PMID: 27856789.
    Citations: 1     Fields:    Translation:HumansCells
  5. Kurokawa K, Takahashi K, Lee BL. The staphylococcal surface-glycopolymer wall teichoic acid (WTA) is crucial for complement activation and immunological defense against Staphylococcus aureus infection. Immunobiology. 2016 10; 221(10):1091-101. PMID: 27424796.
    Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  6. Hori Y, Takeda S, Cho H, Wegmann S, Shoup TM, Takahashi K, Irimia D, Elmaleh DR, Hyman BT, Hudry E. A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid ß in the brain in a transgenic model of Alzheimer disease. J Biol Chem. 2015 Jan 23; 290(4):1966-78. PMID: 25468905.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  7. Takahashi K, Ohtani K, Larvie M, Moyo P, Chigweshe L, Van Cott EM, Wakamiya N. Elevated plasma CL-K1 level is associated with a risk of developing disseminated intravascular coagulation (DIC). J Thromb Thrombolysis. 2014 Oct; 38(3):331-8. PMID: 24474086.
    Citations: 6     Fields:    Translation:Humans
  8. Kang JH, Super M, Yung CW, Cooper RM, Domansky K, Graveline AR, Mammoto T, Berthet JB, Tobin H, Cartwright MJ, Watters AL, Rottman M, Waterhouse A, Mammoto A, Gamini N, Rodas MJ, Kole A, Jiang A, Valentin TM, Diaz A, Takahashi K, Ingber DE. An extracorporeal blood-cleansing device for sepsis therapy. Nat Med. 2014 Oct; 20(10):1211-6. PMID: 25216635.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  9. Nelson B, Zhou X, White M, Hartshorn K, Takahashi K, Kinane TB, Anandaiah A, Koziel H. Recombinant human mannose-binding lectin dampens human alveolar macrophage inflammatory responses to influenza A virus in vitro. J Leukoc Biol. 2014 05; 95(5):715-722. PMID: 24399838.
    Citations: 4     Fields:    Translation:HumansCells
  10. Banda NK, Takahashi K. Analysis of the complement activation in mice. Methods Mol Biol. 2014; 1100:365-71. PMID: 24218276.
    Citations: 3     Fields:    Translation:Animals
  11. Takahashi K, Moyo P, Chigweshe L, Chang WC, White MR, Hartshorn KL. Efficacy of recombinant chimeric lectins, consisting of mannose binding lectin and L-ficolin, against influenza A viral infection in mouse model study. Virus Res. 2013 Dec 26; 178(2):495-501. PMID: 24140629.
    Citations: 2     Fields:    Translation:AnimalsCells
  12. Kurokawa K, Jung DJ, An JH, Fuchs K, Jeon YJ, Kim NH, Li X, Tateishi K, Park JA, Xia G, Matsushita M, Takahashi K, Park HJ, Peschel A, Lee BL. Glycoepitopes of staphylococcal wall teichoic acid govern complement-mediated opsonophagocytosis via human serum antibody and mannose-binding lectin. J Biol Chem. 2013 Oct 25; 288(43):30956-68. PMID: 24045948.
    Citations: 10     Fields:    Translation:HumansCellsCTClinical Trials
  13. Takahashi K, Kurokawa K, Moyo P, Jung DJ, An JH, Chigweshe L, Paul E, Lee BL. Intradermal immunization with wall teichoic acid (WTA) elicits and augments an anti-WTA IgG response that protects mice from methicillin-resistant Staphylococcus aureus infection independent of mannose-binding lectin status. PLoS One. 2013; 8(8):e69739. PMID: 23936347.
    Citations: 4     Fields:    Translation:AnimalsCellsPHPublic Health
  14. Arend WP, Mehta G, Antonioli AH, Takahashi M, Takahashi K, Stahl GL, Holers VM, Banda NK. Roles of adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice. J Immunol. 2013 Jun 15; 190(12):6423-33. PMID: 23650618.
    Citations: 8     Fields:    Translation:AnimalsCells
  15. Brudner M, Karpel M, Lear C, Chen L, Yantosca LM, Scully C, Sarraju A, Sokolovska A, Zariffard MR, Eisen DP, Mungall BA, Kotton DN, Omari A, Huang IC, Farzan M, Takahashi K, Stuart L, Stahl GL, Ezekowitz AB, Spear GT, Olinger GG, Schmidt EV, Michelow IC. Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors. PLoS One. 2013; 8(4):e60838. PMID: 23573288.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  16. Saha D, Takahashi K, de Prost N, Winkler T, Pinilla-Vera M, Baron RM, Vidal Melo MF. Micro-autoradiographic assessment of cell types contributing to 2-deoxy-2-[(18)F]fluoro-D-glucose uptake during ventilator-induced and endotoxemic lung injury. Mol Imaging Biol. 2013 Feb; 15(1):19-27. PMID: 22752654.
    Citations: 16     Fields:    Translation:AnimalsCells
  17. Rothfuchs AG, Roffê E, Gibson A, Cheever AW, Ezekowitz RA, Takahashi K, Steindel M, Sher A, Báfica A. Mannose-binding lectin regulates host resistance and pathology during experimental infection with Trypanosoma cruzi. PLoS One. 2012; 7(11):e47835. PMID: 23139754.
    Citations: 3     Fields:    Translation:HumansAnimals
  18. Jung DJ, An JH, Kurokawa K, Jung YC, Kim MJ, Aoyagi Y, Matsushita M, Takahashi S, Lee HS, Takahashi K, Lee BL. Specific serum Ig recognizing staphylococcal wall teichoic acid induces complement-mediated opsonophagocytosis against Staphylococcus aureus. J Immunol. 2012 Nov 15; 189(10):4951-9. PMID: 23071283.
    Citations: 16     Fields:    Translation:HumansCells
  19. Elvington A, Atkinson C, Zhu H, Yu J, Takahashi K, Stahl GL, Kindy MS, Tomlinson S. The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J Immunol. 2012 Nov 01; 189(9):4640-7. PMID: 23028050.
    Citations: 22     Fields:    Translation:Animals
  20. Verma A, White M, Vathipadiekal V, Tripathi S, Mbianda J, Ieong M, Qi L, Taubenberger JK, Takahashi K, Jensenius JC, Thiel S, Hartshorn KL. Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses. J Immunol. 2012 Sep 01; 189(5):2478-87. PMID: 22851708.
    Citations: 19     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  21. Ali YM, Lynch NJ, Haleem KS, Fujita T, Endo Y, Hansen S, Holmskov U, Takahashi K, Stahl GL, Dudler T, Girija UV, Wallis R, Kadioglu A, Stover CM, Andrew PW, Schwaeble WJ. The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. PLoS Pathog. 2012; 8(7):e1002793. PMID: 22792067.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  22. Larvie M, Shoup T, Chang WC, Chigweshe L, Hartshorn K, White MR, Stahl GL, Elmaleh DR, Takahashi K. Mannose-binding lectin binds to amyloid ß protein and modulates inflammation. J Biomed Biotechnol. 2012; 2012:929803. PMID: 22536027.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  23. Gurm GS, Danik SB, Shoup TM, Weise S, Takahashi K, Laferrier S, Elmaleh DR, Gewirtz H. 4-[18F]-tetraphenylphosphonium as a PET tracer for myocardial mitochondrial membrane potential. JACC Cardiovasc Imaging. 2012 Mar; 5(3):285-92. PMID: 22421174.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  24. Banda NK, Hyatt S, Antonioli AH, White JT, Glogowska M, Takahashi K, Merkel TJ, Stahl GL, Mueller-Ortiz S, Wetsel R, Arend WP, Holers VM. Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice. J Immunol. 2012 Feb 01; 188(3):1469-78. PMID: 22205026.
    Citations: 34     Fields:    Translation:AnimalsCells
  25. La Bonte LR, Pavlov VI, Tan YS, Takahashi K, Takahashi M, Banda NK, Zou C, Fujita T, Stahl GL. Mannose-binding lectin-associated serine protease-1 is a significant contributor to coagulation in a murine model of occlusive thrombosis. J Immunol. 2012 Jan 15; 188(2):885-91. PMID: 22156595.
    Citations: 25     Fields:    Translation:HumansAnimals
  26. Takahashi K. Mannose-binding lectin and the balance between immune protection and complication. Expert Rev Anti Infect Ther. 2011 Dec; 9(12):1179-90. PMID: 22114968.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  27. Ling MT, Tu W, Han Y, Mao H, Chong WP, Guan J, Liu M, Lam KT, Law HK, Peiris JS, Takahashi K, Lau YL. Mannose-binding lectin contributes to deleterious inflammatory response in pandemic H1N1 and avian H9N2 infection. J Infect Dis. 2012 Jan 01; 205(1):44-53. PMID: 22080095.
    Citations: 13     Fields:    Translation:AnimalsCells
  28. Takahashi K, Saha D, Shattino I, Pavlov VI, Stahl GL, Finnegan P, Melo MF. Complement 3 is involved with ventilator-induced lung injury. Int Immunopharmacol. 2011 Dec; 11(12):2138-43. PMID: 21979496.
    Citations: 5     Fields:    Translation:AnimalsCells
  29. Banda NK, Takahashi M, Takahashi K, Stahl GL, Hyatt S, Glogowska M, Wiles TA, Endo Y, Fujita T, Holers VM, Arend WP. Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement. Mol Immunol. 2011 Oct; 49(1-2):281-9. PMID: 21943708.
    Citations: 14     Fields:    Translation:Animals
  30. Sebastian BM, Roychowdhury S, Tang H, Hillian AD, Feldstein AE, Stahl GL, Takahashi K, Nagy LE. Identification of a cytochrome P4502E1/Bid/C1q-dependent axis mediating inflammation in adipose tissue after chronic ethanol feeding to mice. J Biol Chem. 2011 Oct 14; 286(41):35989-97. PMID: 21856753.
    Citations: 20     Fields:    Translation:AnimalsCells
  31. Mershon-Shier KL, Vasuthasawat A, Takahashi K, Morrison SL, Beenhouwer DO. In vitro C3 deposition on Cryptococcus capsule occurs via multiple complement activation pathways. Mol Immunol. 2011 Sep; 48(15-16):2009-18. PMID: 21723612.
    Citations: 5     Fields:    Translation:Animals
  32. Rohrer B, Coughlin B, Kunchithapautham K, Long Q, Tomlinson S, Takahashi K, Holers VM. The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization. Mol Immunol. 2011 Mar; 48(6-7):e1-8. PMID: 21257205.
    Citations: 22     Fields:    Translation:AnimalsCells
  33. Michelow IC, Lear C, Scully C, Prugar LI, Longley CB, Yantosca LM, Ji X, Karpel M, Brudner M, Takahashi K, Spear GT, Ezekowitz RA, Schmidt EV, Olinger GG. High-dose mannose-binding lectin therapy for Ebola virus infection. J Infect Dis. 2011 Jan 15; 203(2):175-9. PMID: 21288816.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  34. Chang WC, White MR, Moyo P, McClear S, Thiel S, Hartshorn KL, Takahashi K. Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection. BMC Immunol. 2010 Dec 23; 11:64. PMID: 21182784.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  35. Chang WC, Hartshorn KL, White MR, Moyo P, Michelow IC, Koziel H, Kinane BT, Schmidt EV, Fujita T, Takahashi K. Recombinant chimeric lectins consisting of mannose-binding lectin and L-ficolin are potent inhibitors of influenza A virus compared with mannose-binding lectin. Biochem Pharmacol. 2011 Feb 01; 81(3):388-95. PMID: 21035429.
    Citations: 10     Fields:    Translation:AnimalsCells
  36. Banda NK, Takahashi M, Levitt B, Glogowska M, Nicholas J, Takahashi K, Stahl GL, Fujita T, Arend WP, Holers VM. Essential role of complement mannose-binding lectin-associated serine proteases-1/3 in the murine collagen antibody-induced model of inflammatory arthritis. J Immunol. 2010 Nov 01; 185(9):5598-606. PMID: 20870940.
    Citations: 18     Fields:    Translation:HumansAnimals
  37. Renner B, Strassheim D, Amura CR, Kulik L, Ljubanovic D, Glogowska MJ, Takahashi K, Carroll MC, Holers VM, Thurman JM. B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion. J Immunol. 2010 Oct 01; 185(7):4393-400. PMID: 20810984.
    Citations: 29     Fields:    Translation:AnimalsCells
  38. Müller S, Schaffer T, Flogerzi B, Seibold-Schmid B, Schnider J, Takahashi K, Darfeuille-Michaud A, Vazeille E, Schoepfer AM, Seibold F. Mannan-binding lectin deficiency results in unusual antibody production and excessive experimental colitis in response to mannose-expressing mild gut pathogens. Gut. 2010 Nov; 59(11):1493-500. PMID: 20682699.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  39. Park KH, Kurokawa K, Zheng L, Jung DJ, Tateishi K, Jin JO, Ha NC, Kang HJ, Matsushita M, Kwak JY, Takahashi K, Lee BL. Human serum mannose-binding lectin senses wall teichoic acid Glycopolymer of Staphylococcus aureus, which is restricted in infancy. J Biol Chem. 2010 Aug 27; 285(35):27167-75. PMID: 20592033.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  40. Michelow IC, Dong M, Mungall BA, Yantosca LM, Lear C, Ji X, Karpel M, Rootes CL, Brudner M, Houen G, Eisen DP, Kinane TB, Takahashi K, Stahl GL, Olinger GG, Spear GT, Ezekowitz RA, Schmidt EV. A novel L-ficolin/mannose-binding lectin chimeric molecule with enhanced activity against Ebola virus. J Biol Chem. 2010 Aug 06; 285(32):24729-39. PMID: 20516066.
    Citations: 21     Fields:    Translation:HumansCells
  41. Ip WK, Sokolovska A, Charriere GM, Boyer L, Dejardin S, Cappillino MP, Yantosca LM, Takahashi K, Moore KJ, Lacy-Hulbert A, Stuart LM. Phagocytosis and phagosome acidification are required for pathogen processing and MyD88-dependent responses to Staphylococcus aureus. J Immunol. 2010 Jun 15; 184(12):7071-81. PMID: 20483752.
    Citations: 44     Fields:    Translation:AnimalsCells
  42. Takahashi K, Chang WC, Takahashi M, Pavlov V, Ishida Y, La Bonte L, Shi L, Fujita T, Stahl GL, Van Cott EM. Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation. Immunobiology. 2011 Jan-Feb; 216(1-2):96-102. PMID: 20399528.
    Citations: 30     Fields:    Translation:AnimalsCells
  43. Banda NK, Levitt B, Glogowska MJ, Thurman JM, Takahashi K, Stahl GL, Tomlinson S, Arend WP, Holers VM. Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice. J Immunol. 2009 Nov 01; 183(9):5928-37. PMID: 19828624.
    Citations: 30     Fields:    Translation:Animals
  44. Busche MN, Pavlov V, Takahashi K, Stahl GL. Myocardial ischemia and reperfusion injury is dependent on both IgM and mannose-binding lectin. Am J Physiol Heart Circ Physiol. 2009 Nov; 297(5):H1853-9. PMID: 19749170.
    Citations: 33     Fields:    Translation:Animals
  45. Ip WK, Takahashi K, Ezekowitz RA, Stuart LM. Mannose-binding lectin and innate immunity. Immunol Rev. 2009 Jul; 230(1):9-21. PMID: 19594626.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  46. Ruseva M, Kolev M, Dagnaes-Hansen F, Hansen SB, Takahashi K, Ezekowitz A, Thiel S, Jensenius JC, Gadjeva M. Mannan-binding lectin deficiency modulates the humoral immune response dependent on the genetic environment. Immunology. 2009 Jun; 127(2):279-88. PMID: 19476514.
    Citations: 12     Fields:    Translation:AnimalsPHPublic Health
  47. Shannon JG, Cockrell DC, Takahashi K, Stahl GL, Heinzen RA. Antibody-mediated immunity to the obligate intracellular bacterial pathogen Coxiella burnetii is Fc receptor- and complement-independent. BMC Immunol. 2009 May 08; 10:26. PMID: 19426498.
    Citations: 17     Fields:    Translation:AnimalsCells
  48. Takahashi K. Lessons learned from murine models of mannose-binding lectin deficiency. Biochem Soc Trans. 2008 Dec; 36(Pt 6):1487-90. PMID: 19021581.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  49. Guttormsen HK, Stuart LM, Shi L, Carroll MC, Chen J, Kasper DL, Ezekowitz RA, Takahashi K. Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination. Clin Immunol. 2009 Mar; 130(3):264-71. PMID: 18996748.
    Citations: 10     Fields:    Translation:AnimalsCellsPHPublic Health
  50. Banda NK, Wood AK, Takahashi K, Levitt B, Rudd PM, Royle L, Abrahams JL, Stahl GL, Holers VM, Arend WP. Initiation of the alternative pathway of murine complement by immune complexes is dependent on N-glycans in IgG antibodies. Arthritis Rheum. 2008 Oct; 58(10):3081-9. PMID: 18821684.
    Citations: 19     Fields:    Translation:Animals
  51. Yager PH, You Z, Qin T, Kim HH, Takahashi K, Ezekowitz AB, Stahl GL, Carroll MC, Whalen MJ. Mannose binding lectin gene deficiency increases susceptibility to traumatic brain injury in mice. J Cereb Blood Flow Metab. 2008 May; 28(5):1030-9. PMID: 18183030.
    Citations: 16     Fields:    Translation:Animals
  52. Ip WK, Takahashi K, Moore KJ, Stuart LM, Ezekowitz RA. Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome. J Exp Med. 2008 Jan 21; 205(1):169-81. PMID: 18180310.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  53. Banda NK, Takahashi K, Wood AK, Holers VM, Arend WP. Pathogenic complement activation in collagen antibody-induced arthritis in mice requires amplification by the alternative pathway. J Immunol. 2007 Sep 15; 179(6):4101-9. PMID: 17785849.
    Citations: 47     Fields:    Translation:AnimalsCells
  54. Murata K, Fox-Talbot K, Qian Z, Takahashi K, Stahl GL, Baldwin WM, Wasowska BA. Synergistic deposition of C4d by complement-activating and non-activating antibodies in cardiac transplants. Am J Transplant. 2007 Nov; 7(11):2605-14. PMID: 17868071.
    Citations: 28     Fields:    Translation:HumansAnimals
  55. Collard CD, Shernan SK, Fox AA, Bernig T, Chanock SJ, Vaughn WK, Takahashi K, Ezekowitz AB, Jarolim P, Body SC. The MBL2 'LYQA secretor' haplotype is an independent predictor of postoperative myocardial infarction in whites undergoing coronary artery bypass graft surgery. Circulation. 2007 Sep 11; 116(11 Suppl):I106-12. PMID: 17846289.
    Citations: 14     Fields:    Translation:Humans
  56. Masui S, Nakatake Y, Toyooka Y, Shimosato D, Yagi R, Takahashi K, Okochi H, Okuda A, Matoba R, Sharov AA, Ko MS, Niwa H. Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat Cell Biol. 2007 Jun; 9(6):625-35. PMID: 17515932.
    Citations: 355     Fields:    Translation:AnimalsCells
  57. Mihai S, Chiriac MT, Takahashi K, Thurman JM, Holers VM, Zillikens D, Botto M, Sitaru C. The alternative pathway of complement activation is critical for blister induction in experimental epidermolysis bullosa acquisita. J Immunol. 2007 May 15; 178(10):6514-21. PMID: 17475881.
    Citations: 15     Fields:    Translation:Animals
  58. You Z, Yang J, Takahashi K, Yager PH, Kim HH, Qin T, Stahl GL, Ezekowitz RA, Carroll MC, Whalen MJ. Reduced tissue damage and improved recovery of motor function after traumatic brain injury in mice deficient in complement component C4. J Cereb Blood Flow Metab. 2007 Dec; 27(12):1954-64. PMID: 17457366.
    Citations: 19     Fields:    Translation:HumansAnimals
  59. Møller-Kristensen M, Hamblin MR, Thiel S, Jensenius JC, Takahashi K. Burn injury reveals altered phenotype in mannan-binding lectin-deficient mice. J Invest Dermatol. 2007 Jun; 127(6):1524-31. PMID: 17363917.
    Citations: 9     Fields:    Translation:Animals
  60. Chan RK, Ibrahim SI, Takahashi K, Kwon E, McCormack M, Ezekowitz A, Carroll MC, Moore FD, Austen WG. The differing roles of the classical and mannose-binding lectin complement pathways in the events following skeletal muscle ischemia-reperfusion. J Immunol. 2006 Dec 01; 177(11):8080-5. PMID: 17114482.
    Citations: 30     Fields:    Translation:HumansAnimals
  61. Zhang M, Takahashi K, Alicot EM, Vorup-Jensen T, Kessler B, Thiel S, Jensenius JC, Ezekowitz RA, Moore FD, Carroll MC. Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury. J Immunol. 2006 Oct 01; 177(7):4727-34. PMID: 16982912.
    Citations: 57     Fields:    Translation:AnimalsCells
  62. McMullen ME, Hart ML, Walsh MC, Buras J, Takahashi K, Stahl GL. Mannose-binding lectin binds IgM to activate the lectin complement pathway in vitro and in vivo. Immunobiology. 2006; 211(10):759-66. PMID: 17113913.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  63. Windbichler M, Echtenacher B, Takahashi K, Ezekowitz RA, Schwaeble WJ, Jenseniuis JC, Männel DN. Investigations on the involvement of the lectin pathway of complement activation in anaphylaxis. Int Arch Allergy Immunol. 2006; 141(1):11-23. PMID: 16804320.
    Citations: 1     Fields:    Translation:AnimalsCells
  64. Sugai Y, Komatani A, Hosoya T, Takahashi K. Comparisons of the time-activity curves of the cardiac blood pool and liver uptake by 99mTc-GSA dynamic SPECT and measured 99mTc-GSA blood concentrations. Ann Nucl Med. 2006 May; 20(4):295-301. PMID: 16856573.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  65. Podolsky MJ, Lasker A, Flaminio MJ, Gowda LD, Ezekowitz RA, Takahashi K. Characterization of an equine mannose-binding lectin and its roles in disease. Biochem Biophys Res Commun. 2006 May 12; 343(3):928-36. PMID: 16574074.
    Citations: 3     Fields:    Translation:AnimalsCells
  66. Kissler S, Stern P, Takahashi K, Hunter K, Peterson LB, Wicker LS. In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes. Nat Genet. 2006 Apr; 38(4):479-83. PMID: 16550170.
    Citations: 51     Fields:    Translation:Animals
  67. Møller-Kristensen M, Ip WK, Shi L, Gowda LD, Hamblin MR, Thiel S, Jensenius JC, Ezekowitz RA, Takahashi K. Deficiency of mannose-binding lectin greatly increases susceptibility to postburn infection with Pseudomonas aeruginosa. J Immunol. 2006 Feb 01; 176(3):1769-75. PMID: 16424207.
    Citations: 27     Fields:    Translation:AnimalsCells
  68. Takahashi K, Ip WE, Michelow IC, Ezekowitz RA. The mannose-binding lectin: a prototypic pattern recognition molecule. Curr Opin Immunol. 2006 Feb; 18(1):16-23. PMID: 16368230.
    Citations: 49     Fields:    Translation:HumansAnimals
  69. Takahashi K, Shi L, Gowda LD, Ezekowitz RA. Relative roles of complement factor 3 and mannose-binding lectin in host defense against infection. Infect Immun. 2005 Dec; 73(12):8188-93. PMID: 16299314.
    Citations: 14     Fields:    Translation:AnimalsCells
  70. Takahashi K, Ezekowitz RA. The role of the mannose-binding lectin in innate immunity. Clin Infect Dis. 2005 Nov 15; 41 Suppl 7:S440-4. PMID: 16237644.
    Citations: 24     Fields:    Translation:HumansAnimals
  71. Stuart LM, Deng J, Silver JM, Takahashi K, Tseng AA, Hennessy EJ, Ezekowitz RA, Moore KJ. Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain. J Cell Biol. 2005 Aug 01; 170(3):477-85. PMID: 16061696.
    Citations: 125     Fields:    Translation:AnimalsCells
  72. Walsh MC, Bourcier T, Takahashi K, Shi L, Busche MN, Rother RP, Solomon SD, Ezekowitz RA, Stahl GL. Mannose-binding lectin is a regulator of inflammation that accompanies myocardial ischemia and reperfusion injury. J Immunol. 2005 Jul 01; 175(1):541-6. PMID: 15972690.
    Citations: 77     Fields:    Translation:Animals
  73. Hart ML, Ceonzo KA, Shaffer LA, Takahashi K, Rother RP, Reenstra WR, Buras JA, Stahl GL. Gastrointestinal ischemia-reperfusion injury is lectin complement pathway dependent without involving C1q. J Immunol. 2005 May 15; 174(10):6373-80. PMID: 15879138.
    Citations: 72     Fields:    Translation:HumansAnimals
  74. Møller-Kristensen M, Wang W, Ruseva M, Thiel S, Nielsen S, Takahashi K, Shi L, Ezekowitz A, Jensenius JC, Gadjeva M. Mannan-binding lectin recognizes structures on ischaemic reperfused mouse kidneys and is implicated in tissue injury. Scand J Immunol. 2005 May; 61(5):426-34. PMID: 15882434.
    Citations: 50     Fields:    Translation:Animals
  75. Stuart LM, Takahashi K, Shi L, Savill J, Ezekowitz RA. Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype. J Immunol. 2005 Mar 15; 174(6):3220-6. PMID: 15749852.
    Citations: 62     Fields:    Translation:AnimalsCells
  76. Ezekowitz RA, Shi L, Fraser I, Takahashi K. The mannose-binding lectin: an infection susceptibility gene. Adv Exp Med Biol. 2005; 560:99-103. PMID: 15932025.
    Citations: 2     Fields:    Translation:HumansAnimals
  77. Gadjeva M, Paludan SR, Thiel S, Slavov V, Ruseva M, Eriksson K, Löwhagen GB, Shi L, Takahashi K, Ezekowitz A, Jensenius JC. Mannan-binding lectin modulates the response to HSV-2 infection. Clin Exp Immunol. 2004 Nov; 138(2):304-11. PMID: 15498041.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  78. Gadjeva M, Takahashi K, Thiel S. Mannan-binding lectin--a soluble pattern recognition molecule. Mol Immunol. 2004 Jun; 41(2-3):113-21. PMID: 15159056.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  79. Shi L, Takahashi K, Dundee J, Shahroor-Karni S, Thiel S, Jensenius JC, Gad F, Hamblin MR, Sastry KN, Ezekowitz RA. Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus. J Exp Med. 2004 May 17; 199(10):1379-90. PMID: 15148336.
    Citations: 76     Fields:    Translation:Animals
  80. Hogaboam CM, Takahashi K, Ezekowitz RA, Kunkel SL, Schuh JM. Mannose-binding lectin deficiency alters the development of fungal asthma: effects on airway response, inflammation, and cytokine profile. J Leukoc Biol. 2004 May; 75(5):805-14. PMID: 14761934.
    Citations: 9     Fields:    Translation:HumansAnimals
  81. Takahashi K, Gordon J, Liu H, Sastry KN, Epstein JE, Motwani M, Laursen I, Thiel S, Jensenius JC, Carroll M, Ezekowitz RA. Lack of mannose-binding lectin-A enhances survival in a mouse model of acute septic peritonitis. Microbes Infect. 2002 Jul; 4(8):773-84. PMID: 12270724.
    Citations: 28     Fields:    Translation:AnimalsCells
  82. Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D. Arthritis critically dependent on innate immune system players. Immunity. 2002 Feb; 16(2):157-68. PMID: 11869678.
    Citations: 224     Fields:    Translation:AnimalsCells
  83. Fraser IP, Takahashi K, Koziel H, Fardin B, Harmsen A, Ezekowitz RA. Pneumocystis carinii enhances soluble mannose receptor production by macrophages. Microbes Infect. 2000 Sep; 2(11):1305-10. PMID: 11018446.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  84. White MR, Crouch E, Chang D, Sastry K, Guo N, Engelich G, Takahashi K, Ezekowitz RA, Hartshorn KL. Enhanced antiviral and opsonic activity of a human mannose-binding lectin and surfactant protein D chimera. J Immunol. 2000 Aug 15; 165(4):2108-15. PMID: 10925296.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  85. Takahashi K, Mulliken JB, Kozakewich HP, Rogers RA, Folkman J, Ezekowitz RA. Cellular markers that distinguish the phases of hemangioma during infancy and childhood. J Clin Invest. 1994 Jun; 93(6):2357-64. PMID: 7911127.
    Citations: 91     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.