Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Lester Kobzik, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI125152 (LU, QUAN) May 19, 2016 - Apr 30, 2020
    Plasma Gelsolin as Immunotherapeutic for Antibiotic-Resistant Pneumonia
    Role: Principal Investigator
  2. R13AI109838 (KOBZIK, LESTER) Jan 1, 2014 - May 31, 2014
    2014 Biology of Acute Respiratory Infection Gordon Research Conference and Semina
    Role: Principal Investigator
  3. R21ES023281 (KOBZIK, LESTER) Aug 30, 2013 - Jul 31, 2016
    Transgenerational Susceptibility to Asthma from Air Pollution Exposure
    Role: Principal Investigator
  4. R01HL115778 (KOBZIK, LESTER) Jan 11, 2013 - Jul 31, 2017
    Plasma Gelsolin and Host Defense After Lung Injury
    Role: Principal Investigator
  5. R21ES019825 (KOBZIK, LESTER) Jun 1, 2011 - May 31, 2014
    RNAi Screen in Air Pollutant-Enhanced Influenza Infection
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Inde Z, Croker BA, Yapp C, Joshi GN, Spetz J, Fraser C, Qin X, Xu L, Deskin B, Ghelfi E, Webb G, Carlin AF, Zhu YP, Leibel SL, Garretson AF, Clark AE, Duran JM, Pretorius V, Crotty-Alexander LE, Li C, Lee JC, Sodhi C, Hackam DJ, Sun X, Hata AN, Kobzik L, Miller J, Park JA, Brownfield D, Jia H, Sarosiek KA. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity. Sci Adv. 2021 08; 7(34). PMID: 34407940.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  2. Chatterjee S, Yabaji SM, Rukhlenko OS, Bhattacharya B, Waligurski E, Vallavoju N, Ray S, Kholodenko BN, Brown LE, Beeler AB, Ivanov AR, Kobzik L, Porco JA, Kramnik I. Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis. iScience. 2021 Aug 20; 24(8):102845. PMID: 34381970.
  3. Bhattacharya B, Xiao S, Chatterjee S, Urbanowski M, Ordonez A, Ihms EA, Agrahari G, Lun S, Berland R, Pichugin A, Gao Y, Connor J, Ivanov AR, Yan BS, Kobzik L, Koo BB, Jain S, Bishai W, Kramnik I. The integrated stress response mediates necrosis in murine Mycobacterium tuberculosis granulomas. J Clin Invest. 2021 02 01; 131(3). PMID: 33301427.
    Citations: 3     Fields:    Translation:AnimalsCells
  4. Inde Z, Yapp C, Joshi GN, Spetz J, Fraser C, Deskin B, Ghelfi E, Sodhi C, Hackam D, Kobzik L, Croker B, Brownfield D, Jia H, Sarosiek KA. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity. bioRxiv. 2020 Sep 13. PMID: 32935109.
  5. Gregory DJ, DeLoid GM, Salmon SL, Metzger DW, Kramnik I, Kobzik L. SON DNA-binding protein mediates macrophage autophagy and responses to intracellular infection. FEBS Lett. 2020 09; 594(17):2782-2799. PMID: 32484234.
    Citations: 1     Fields:    Translation:HumansCells
  6. Joffre J, Yeh CC, Wong E, Thete M, Xu F, Zlatanova I, Lloyd E, Kobzik L, Legrand M, Hellman J. Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury. J Immunol. 2020 06 15; 204(12):3339-3350. PMID: 32385136.
    Citations: 7     Fields:    Translation:AnimalsCells
  7. Petkovic D, Kobzik L, Ghanadan R. AI Ethics and Values in Biomedicine - Technical Challenges and Solutions. Pac Symp Biocomput. 2020; 25:731-735. PMID: 31797642.
  8. Yang Z, Bedugnis A, Levinson S, DiNubile M, Stossel T, Lu Q, Kobzik L. Delayed administration of recombinant plasma gelsolin improves survival in a murine model of severe influenza. F1000Res. 2019; 8:1860. PMID: 31824672.
    Citations: 3     Fields:    
  9. Yang Z, Bedugnis A, Levinson S, Dinubile M, Stossel T, Lu Q, Kobzik L. Delayed Administration of Recombinant Plasma Gelsolin Improves Survival in a Murine Model of Penicillin-Susceptible and Penicillin-Resistant Pneumococcal Pneumonia. J Infect Dis. 2019 09 26; 220(9):1498-1502. PMID: 31287867.
    Citations: 2     Fields:    Translation:Animals
  10. Vaze N, Pyrgiotakis G, McDevitt J, Mena L, Melo A, Bedugnis A, Kobzik L, Eleftheriadou M, Demokritou P. Inactivation of common hospital acquired pathogens on surfaces and in air utilizing engineered water nanostructures (EWNS) based nano-sanitizers. Nanomedicine. 2019 06; 18:234-242. PMID: 30904585.
    Citations: 5     Fields:    
  11. Yang X, Shen H, Buckley B, Chen Y, Yang N, Mussell AL, Chernov M, Kobzik L, Frangou C, Han SX, Zhang J. NTRK1 is a positive regulator of YAP oncogenic function. Oncogene. 2019 04; 38(15):2778-2787. PMID: 30542115.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  12. Liang X, Gupta K, Quintero JR, Cernadas M, Kobzik L, Christou H, Pier GB, Owen CA, Çataltepe S. Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia. FASEB J. 2019 03; 33(3):3562-3574. PMID: 30462529.
    Citations: 7     Fields:    Translation:AnimalsCells
  13. Joachim RB, Kobzik L. Why are children more resistant to mortality from severe infections? Future Microbiol. 2018 11; 13:1549-1552. PMID: 30421979.
    Citations: 1     Fields:    Translation:HumansAnimals
  14. Shen H, Yang N, Truskinovsky A, Chen Y, Mussell AL, Nowak NJ, Kobzik L, Frangou C, Zhang J. Targeting TAZ-Driven Human Breast Cancer by Inhibiting a SKP2-p27 Signaling Axis. Mol Cancer Res. 2019 01; 17(1):250-262. PMID: 30237296.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  15. Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP. Future Research Directions in Pneumonia. NHLBI Working Group Report. Am J Respir Crit Care Med. 2018 07 15; 198(2):256-263. PMID: 29546996.
    Citations: 21     Fields:    Translation:Humans
  16. Joachim RB, Altschuler GM, Hutchinson JN, Wong HR, Hide WA, Kobzik L. The relative resistance of children to sepsis mortality: from pathways to drug candidates. Mol Syst Biol. 2018 05 17; 14(5):e7998. PMID: 29773677.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  17. Petkovic D, Kobzik L, Re C. Machine learning and deep analytics for biocomputing: call for better explainability. Pac Symp Biocomput. 2018; 23:623-627. PMID: 29218921.
    Citations: 3     Fields:    Translation:Humans
  18. Gregory DJ, Kramnik I, Kobzik L. Protection of macrophages from intracellular pathogens by miR-182-5p mimic-a gene expression meta-analysis approach. FEBS J. 2018 01; 285(2):244-260. PMID: 29197182.
    Citations: 2     Fields:    Translation:HumansCells
  19. Joachim R, Suber F, Kobzik L. Characterising Pre-pubertal Resistance to Death from Endotoxemia. Sci Rep. 2017 11 29; 7(1):16541. PMID: 29185479.
    Citations: 3     Fields:    Translation:Animals
  20. Killpack TL, Ballesteros M, Bunnell SC, Bedugnis A, Kobzik L, Hu LT, Petnicki-Ocwieja T. Phagocytic Receptors Activate Syk and Src Signaling during Borrelia burgdorferi Phagocytosis. Infect Immun. 2017 10; 85(10). PMID: 28717031.
    Citations: 4     Fields:    Translation:AnimalsCells
  21. Suber F, Kobzik L. Childhood tolerance of severe influenza: a mortality analysis in mice. . 2017 Dec 01; 313(6):L1087-L1095. PMID: 28882815.
    Citations: 5     Translation:HumansAnimalsCells
  22. Gamradt P, Xu Y, Gratz N, Duncan K, Kobzik L, Högler S, Kovarik P, Decker T, Jamieson AM. Correction: The Influence of Programmed Cell Death in Myeloid Cells on Host Resilience to Infection with Legionella pneumophila or Streptococcus pyogenes. PLoS Pathog. 2017 Aug; 13(8):e1006591. PMID: 28854275.
    Citations:    Fields: