Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Lester Kobzik, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI125152 (KOBZIK, LESTER) May 19, 2016 - Apr 30, 2019
    Plasma Gelsolin as Immunotherapeutic for Antibiotic-Resistant Pneumonia
    Role: Principal Investigator
  2. R13AI109838 (KOBZIK, LESTER) Jan 1, 2014 - May 31, 2014
    2014 Biology of Acute Respiratory Infection Gordon Research Conference and Semina
    Role: Principal Investigator
  3. R21ES023281 (KOBZIK, LESTER) Aug 30, 2013 - Jul 31, 2015
    Transgenerational Susceptibility to Asthma from Air Pollution Exposure
    Role: Principal Investigator
  4. R01HL115778 (KOBZIK, LESTER) Jan 11, 2013 - Jan 31, 2017
    Plasma Gelsolin and Host Defense After Lung Injury
    Role: Principal Investigator
  5. R21ES019825 (KOBZIK, LESTER) Jun 1, 2011 - May 31, 2014
    RNAi Screen in Air Pollutant-Enhanced Influenza Infection
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gregory DJ, DeLoid GM, Salmon SL, Metzger DW, Kramnik I, Kobzik L. SON DNA-binding protein mediates macrophage autophagy and responses to intracellular infection. FEBS Lett. 2020 Jun 02. PMID: 32484234.
  2. Joffre J, Yeh CC, Wong E, Thete M, Xu F, Zlatanova I, Lloyd E, Kobzik L, Legrand M, Hellman J. Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury. J Immunol. 2020 Jun 15; 204(12):3339-3350. PMID: 32385136.
  3. Petkovic D, Kobzik L, Ghanadan R. AI Ethics and Values in Biomedicine - Technical Challenges and Solutions. Pac Symp Biocomput. 2020; 25:731-735. PMID: 31797642.
  4. Yang Z, Bedugnis A, Levinson S, DiNubile M, Stossel T, Lu Q, Kobzik L. Delayed administration of recombinant plasma gelsolin improves survival in a murine model of severe influenza. F1000Res. 2019; 8:1860. PMID: 31824672.
  5. Yang Z, Bedugnis A, Levinson S, Dinubile M, Stossel T, Lu Q, Kobzik L. Delayed Administration of Recombinant Plasma Gelsolin Improves Survival in a Murine Model of Penicillin-Susceptible and Penicillin-Resistant Pneumococcal Pneumonia. J Infect Dis. 2019 09 26; 220(9):1498-1502. PMID: 31287867.
  6. Vaze N, Pyrgiotakis G, McDevitt J, Mena L, Melo A, Bedugnis A, Kobzik L, Eleftheriadou M, Demokritou P. Inactivation of common hospital acquired pathogens on surfaces and in air utilizing engineered water nanostructures (EWNS) based nano-sanitizers. Nanomedicine. 2019 06; 18:234-242. PMID: 30904585.
  7. Yang X, Shen H, Buckley B, Chen Y, Yang N, Mussell AL, Chernov M, Kobzik L, Frangou C, Han SX, Zhang J. NTRK1 is a positive regulator of YAP oncogenic function. Oncogene. 2019 04; 38(15):2778-2787. PMID: 30542115.
  8. Liang X, Gupta K, Quintero JR, Cernadas M, Kobzik L, Christou H, Pier GB, Owen CA, Çataltepe S. Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia. FASEB J. 2019 03; 33(3):3562-3574. PMID: 30462529.
    Citations:    Fields:    
  9. Joachim RB, Kobzik L. Why are children more resistant to mortality from severe infections? Future Microbiol. 2018 11; 13:1549-1552. PMID: 30421979.
    Citations:    Fields:    
  10. Shen H, Yang N, Truskinovsky A, Chen Y, Mussell AL, Nowak NJ, Kobzik L, Frangou C, Zhang J. Targeting TAZ-Driven Human Breast Cancer by Inhibiting a SKP2-p27 Signaling Axis. Mol Cancer Res. 2019 01; 17(1):250-262. PMID: 30237296.
    Citations:    Fields:    
  11. Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP. Future Research Directions in Pneumonia. NHLBI Working Group Report. Am J Respir Crit Care Med. 2018 07 15; 198(2):256-263. PMID: 29546996.
    Citations: 2     Fields:    
  12. Joachim RB, Altschuler GM, Hutchinson JN, Wong HR, Hide WA, Kobzik L. The relative resistance of children to sepsis mortality: from pathways to drug candidates. Mol Syst Biol. 2018 05 17; 14(5):e7998. PMID: 29773677.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Petkovic D, Kobzik L, Re C. Machine learning and deep analytics for biocomputing: call for better explainability. Pac Symp Biocomput. 2018; 23:623-627. PMID: 29218921.
    Citations:    Fields:    Translation:Humans
  14. Gregory DJ, Kramnik I, Kobzik L. Protection of macrophages from intracellular pathogens by miR-182-5p mimic-a gene expression meta-analysis approach. FEBS J. 2018 01; 285(2):244-260. PMID: 29197182.
    Citations:    Fields:    Translation:HumansCells
  15. Joachim R, Suber F, Kobzik L. Characterising Pre-pubertal Resistance to Death from Endotoxemia. Sci Rep. 2017 11 29; 7(1):16541. PMID: 29185479.
    Citations: 1     Fields:    
  16. Killpack TL, Ballesteros M, Bunnell SC, Bedugnis A, Kobzik L, Hu LT, Petnicki-Ocwieja T. Phagocytic Receptors Activate Syk and Src Signaling during Borrelia burgdorferi Phagocytosis. Infect Immun. 2017 10; 85(10). PMID: 28717031.
    Citations:    Fields:    Translation:AnimalsCells
  17. Suber F, Kobzik L. Childhood tolerance of severe influenza: a mortality analysis in mice. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L1087-L1095. PMID: 28882815.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  18. Gamradt P, Xu Y, Gratz N, Duncan K, Kobzik L, Högler S, Kovarik P, Decker T, Jamieson AM. Correction: The Influence of Programmed Cell Death in Myeloid Cells on Host Resilience to Infection with Legionella pneumophila or Streptococcus pyogenes. PLoS Pathog. 2017 Aug; 13(8):e1006591. PMID: 28854275.
    Citations:    Fields:    
  19. Divakaran S, Dellaripa P, Kobzik L, Levy B, Loscalzo J. All That Wheezes…. N Engl J Med. 2017 08 03; 377(5):477-484. PMID: 28767340.
    Citations: 1     Fields:    Translation:Humans
  20. Divakaran S, Vaidya A, Kobzik L, Dellaripa P. All That Wheezes... N Engl J Med. 2017 07 27; 377(4):e6. PMID: 28745993.
    Citations:    Fields:    Translation:Humans
  21. PrabhuDas MR, Baldwin CL, Bollyky PL, Bowdish DME, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, McVicker B, Means TK, Moestrup SK, Post SR, Sawamura T, Silverstein S, Speth RC, Telfer JC, Thiele GM, Wang XY, Wright SD, El Khoury J. A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease. J Immunol. 2017 05 15; 198(10):3775-3789. PMID: 28483986.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  22. Gregory DJ, Kobzik L, Yang Z, McGuire CC, Fedulov AV. Transgenerational transmission of asthma risk after exposure to environmental particles during pregnancy. Am J Physiol Lung Cell Mol Physiol. 2017 08 01; 313(2):L395-L405. PMID: 28495853.
    Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
  23. Wu M, Gibbons JG, DeLoid GM, Bedugnis AS, Thimmulappa RK, Biswal S, Kobzik L. Immunomodulators targeting MARCO expression improve resistance to postinfluenza bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol. 2017 07 01; 313(1):L138-L153. PMID: 28408365.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  24. Ordija CM, Chiou TT, Yang Z, Deloid GM, de Oliveira Valdo M, Wang Z, Bedugnis A, Noah TL, Jones S, Koziel H, Kobzik L. Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma gelsolin. Am J Physiol Lung Cell Mol Physiol. 2017 06 01; 312(6):L1018-L1028. PMID: 28385809.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  25. Kobzik L. Searching for a Lifeline: Transcriptome Profiling Studies of Influenza Susceptibility and Resistance. J Innate Immun. 2017; 9(3):232-242. PMID: 28249256.
    Citations:    Fields:    Translation:HumansAnimalsCells
  26. Meyer KF, Krauss-Etschmann S, Kooistra W, Reinders-Luinge M, Timens W, Kobzik L, Plösch T, Hylkema MN. Prenatal exposure to tobacco smoke sex dependently influences methylation and mRNA levels of the Igf axis in lungs of mouse offspring. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 01; 312(4):L542-L555. PMID: 28130259.
    Citations: 3     Fields:    
  27. Meyer KF, Verkaik-Schakel RN, Timens W, Kobzik L, Plösch T, Hylkema MN. The fetal programming effect of prenatal smoking on Igf1r and Igf1 methylation is organ- and sex-specific. Epigenetics. 2017; 12(12):1076-1091. PMID: 29160127.
    Citations: 2     Fields:    Translation:AnimalsCells
  28. Gamradt P, Xu Y, Gratz N, Duncan K, Kobzik L, Högler S, Kovarik P, Decker T, Jamieson AM. The Influence of Programmed Cell Death in Myeloid Cells on Host Resilience to Infection with Legionella pneumophila or Streptococcus pyogenes. PLoS Pathog. 2016 Dec; 12(12):e1006032. PMID: 27973535.
    Citations: 3     Fields:    Translation:AnimalsCells
  29. High M, Cho HY, Marzec J, Wiltshire T, Verhein KC, Caballero MT, Acosta PL, Ciencewicki J, McCaw ZR, Kobzik L, Miller-DeGraff L, Gladwell W, Peden DB, Serra ME, Shi M, Weinberg C, Suzuki O, Wang X, Bell DA, Polack FP, Kleeberger SR. Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants. EBioMedicine. 2016 Sep; 11:73-84. PMID: 27554839.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  30. DeLoid G, Casella B, Pirela S, Filoramo R, Pyrgiotakis G, Demokritou P, Kobzik L. Effects of engineered nanomaterial exposure on macrophage innate immune function. NanoImpact. 2016 Apr; 2:70-81. PMID: 29568809.
    Citations: 1     
  31. Jiang Z, Lao T, Qiu W, Polverino F, Gupta K, Guo F, Mancini JD, Naing ZZ, Cho MH, Castaldi PJ, Sun Y, Yu J, Laucho-Contreras ME, Kobzik L, Raby BA, Choi AM, Perrella MA, Owen CA, Silverman EK, Zhou X. A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of ß-Catenin. Am J Respir Crit Care Med. 2016 07 15; 194(2):185-97. PMID: 26862784.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  32. Mayo L, Cunha AP, Madi A, Beynon V, Yang Z, Alvarez JI, Prat A, Sobel RA, Kobzik L, Lassmann H, Quintana FJ, Weiner HL. IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation. Brain. 2016 07; 139(Pt 7):1939-57. PMID: 27246324.
    Citations: 7     Fields:    Translation:AnimalsCells
  33. Bhattacharya B, Chatterjee S, Devine WG, Kobzik L, Beeler AB, Porco JA, Kramnik I. Fine-tuning of macrophage activation using synthetic rocaglate derivatives. Sci Rep. 2016 Apr 18; 6:24409. PMID: 27086720.
    Citations: 2     Fields:    Translation:AnimalsCells
  34. Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F, Kobzik L, Kain KC, Lu S, Santel A, Yano K, Guha P, Dumont DJ, Christiani DC, Parikh SM. Gene control of tyrosine kinase TIE2 and vascular manifestations of infections. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):2472-7. PMID: 26884170.
    Citations: 17     Fields:    Translation:Animals
  35. Puchta A, Naidoo A, Verschoor CP, Loukov D, Thevaranjan N, Mandur TS, Nguyen PS, Jordana M, Loeb M, Xing Z, Kobzik L, Larché MJ, Bowdish DM. TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity. PLoS Pathog. 2016 Jan; 12(1):e1005368. PMID: 26766566.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  36. Gregory DJ, Kobzik L. Influenza lung injury: mechanisms and therapeutic opportunities. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15; 309(10):L1041-6. PMID: 26408556.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  37. Pirela SV, Miousse IR, Lu X, Castranova V, Thomas T, Qian Y, Bello D, Kobzik L, Koturbash I, Demokritou P. Effects of Laser Printer-Emitted Engineered Nanoparticles on Cytotoxicity, Chemokine Expression, Reactive Oxygen Species, DNA Methylation, and DNA Damage: A Comprehensive in Vitro Analysis in Human Small Airway Epithelial Cells, Macrophages, and Lymphoblasts. Environ Health Perspect. 2016 Feb; 124(2):210-9. PMID: 26080392.
    Citations: 12     Fields:    Translation:HumansCells
  38. Yang Z, Chiou TT, Stossel TP, Kobzik L. Plasma gelsolin improves lung host defense against pneumonia by enhancing macrophage NOS3 function. Am J Physiol Lung Cell Mol Physiol. 2015 Jul 01; 309(1):L11-6. PMID: 25957291.
    Citations: 9     Fields:    Translation:AnimalsCells
  39. Murthy S, Larson-Casey JL, Ryan AJ, He C, Kobzik L, Carter AB. Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure. FASEB J. 2015 Aug; 29(8):3527-36. PMID: 25953850.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  40. Yang Z, Huang YC, Koziel H, de Crom R, Ruetten H, Wohlfart P, Thomsen RW, Kahlert JA, Sørensen HT, Jozefowski S, Colby A, Kobzik L. Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target. Elife. 2014 Oct 15; 3. PMID: 25317947.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  41. Kissick HT, Dunn LK, Ghosh S, Nechama M, Kobzik L, Arredouani MS. The scavenger receptor MARCO modulates TLR-induced responses in dendritic cells. PLoS One. 2014; 9(8):e104148. PMID: 25089703.
    Citations: 6     Fields:    Translation:AnimalsCells
  42. Gaughan DM, Siegel PD, Hughes MD, Chang CY, Law BF, Campbell CR, Richards JC, Kales SF, Chertok M, Kobzik L, Nguyen PS, O'Donnell CR, Kiefer M, Wagner GR, Christiani DC. Arterial stiffness, oxidative stress, and smoke exposure in wildland firefighters. Am J Ind Med. 2014 Jul; 57(7):748-56. PMID: 24909863.
    Citations: 2     Fields: