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Li Chai, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03CA184531 (CHAI, LI) Jul 6, 2015 - Jun 30, 2017
    NIH/NCI
    Murine Models on SALL4 in Hepatocellular Carcinoma
    Role: Principal Investigator
  2. R01HL092437 (CHAI, LI) Jul 1, 2009 - Jun 30, 2011
    NIH/NHLBI
    SELF-RENEWAL IN LEUKEMIC STEM CELLS
    Role: Principal Investigator
  3. P01HL095489 (SILBERSTEIN, LESLIE ERIC) Apr 1, 2009 - Mar 31, 2021
    NIH/NHLBI
    Molecular Mechanisms of Blood Cell Transfusion
    Role: Co-Principal Investigator
  4. K08DK063220 (CHAI, LI) Aug 1, 2003 - Sep 30, 2003
    NIH/NIDDK
    Hsal 2, A Novel Homeobox Gene in Hematopoiesis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Liu M, Chen Z, Dai MY, Yang JH, Chen XB, Chen D, You H, Guo X, Leng Y, Yu L, Zhang ML, Wu X, Yang J, Gao C, Tenen DG, Chai L, Ai F. Lessons learned from early compassionate use of convalescent plasma on critically ill patients with Covid-19. Transfusion. 2020 Aug 08. PMID: 32770691.
    Citations:    Fields:    
  2. Xu LH, Fang JP, Liu YC, Jones AI, Chai L. Nucleophosmin mutations confer an independent favorable prognostic impact in 869 pediatric patients with acute myeloid leukemia. Blood Cancer J. 2020 01 09; 10(1):1. PMID: 31915364.
    Citations:    
  3. Huang M, Yang W, Zhu J, Mariño-Enríquez A, Zhu C, Chen J, Wu Y, Quan Y, Qiu H, Li X, Chai L, Fletcher JA, Ou WB. Coordinated targeting of CK2 and KIT in gastrointestinal stromal tumours. Br J Cancer. 2020 02; 122(3):372-381. PMID: 31776458.
    Citations:    Fields:    
  4. Tan JL, Li F, Yeo JZ, Yong KJ, Bassal MA, Ng GH, Lee MY, Leong CY, Tan HK, Wu CS, Liu BH, Chan TH, Tan ZH, Chan YS, Wang S, Lim ZH, Toh TB, Hooi L, Low KN, Ma S, Kong NR, Stein AJ, Wu Y, Thangavelu MT, Suzuki A, Periyasamy G, Asara JM, Dan YY, Bonney GK, Chow EK, Lu GD, Ng HH, Kanagasundaram Y, Ng SB, Tam WL, Tenen DG, Chai L. New High-Throughput Screening Identifies Compounds That Reduce Viability Specifically in Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation. Gastroenterology. 2019 12; 157(6):1615-1629.e17. PMID: 31446059.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  5. Tatetsu H, Armant M, Wang F, Gao C, Ueno S, Tian X, Federation A, Qi J, Bradner J, Tenen DG, Chai L. Maintenance and enhancement of human peripheral blood mobilized stem/progenitor cell engraftment after ex vivo culture via an HDACi/SALL4 axis (3465). Exp Hematol. 2019 07; 75:53-63.e11. PMID: 31260717.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Liu BH, Jobichen C, Chia CSB, Chan THM, Tang JP, Chung TXY, Li J, Poulsen A, Hung AW, Koh-Stenta X, Tan YS, Verma CS, Tan HK, Wu CS, Li F, Hill J, Joy J, Yang H, Chai L, Sivaraman J, Tenen DG. Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):E7119-E7128. PMID: 29976840.
    Citations: 8     Fields:    Translation:HumansCells
  7. Zhu H, Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Kambara H, Yu H, Chai L, Silberstein LE, Cheng T, Luo HR. Reactive Oxygen Species-Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation-Induced Reactive Granulopoiesis. J Immunol. 2017 04 01; 198(7):2854-2864. PMID: 28235862.
    Citations: 3     Fields:    Translation:AnimalsCells
  8. Yong KJ, Li A, Ou WB, Hong CK, Zhao W, Wang F, Tatetsu H, Yan B, Qi L, Fletcher JA, Yang H, Soo R, Tenen DG, Chai L. Targeting SALL4 by entinostat in lung cancer. Oncotarget. 2016 Nov 15; 7(46):75425-75440. PMID: 27705911.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  9. Wang F, Gao C, Lu J, Tatetsu H, Williams DA, Müller LU, Cui W, Chai L. Leukemic survival factor SALL4 contributes to defective DNA damage repair. Oncogene. 2016 11 24; 35(47):6087-6095. PMID: 27132514.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  10. Kong NR, Davis M, Chai L, Winoto A, Tjian R. MEF2C and EBF1 Co-regulate B Cell-Specific Transcription. PLoS Genet. 2016 Feb; 12(2):e1005845. PMID: 26900922.
    Citations: 8     Fields:    Translation:HumansCells
  11. Tatetsu H, Kong NR, Chong G, Amabile G, Tenen DG, Chai L. SALL4, the missing link between stem cells, development and cancer. Gene. 2016 Jun 15; 584(2):111-9. PMID: 26892498.
    Citations: 12     Fields:    Translation:HumansCells
  12. Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Sun Y, Zhu H, Chai L, Silberstein LE, Cheng T, Luo HR. Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis. Immunity. 2015 Jan 20; 42(1):159-71. PMID: 25579427.
    Citations: 25     Fields:    Translation:AnimalsCells
  13. Ueno S, Lu J, He J, Li A, Zhang X, Ritz J, Silberstein LE, Chai L. Aberrant expression of SALL4 in acute B cell lymphoblastic leukemia: mechanism, function, and implication for a potential novel therapeutic target. Exp Hematol. 2014 Apr; 42(4):307-316.e8. PMID: 24463278.
    Citations: 13     Fields:    Translation:HumansCellsCTClinical Trials
  14. Wang F, Zhao W, Kong N, Cui W, Chai L. The next new target in leukemia: The embryonic stem cell gene SALL4. Mol Cell Oncol. 2014; 1(4):e969169. PMID: 25977939.
    Citations: 8     
  15. Li A, Jiao Y, Yong KJ, Wang F, Gao C, Yan B, Srivastava S, Lim GS, Tang P, Yang H, Tenen DG, Chai L. SALL4 is a new target in endometrial cancer. Oncogene. 2015 Jan 02; 34(1):63-72. PMID: 24336327.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  16. Li A, Yang Y, Gao C, Lu J, Jeong HW, Liu BH, Tang P, Yao X, Neuberg D, Huang G, Tenen DG, Chai L. A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis. J Clin Invest. 2013 Oct; 123(10):4195-207. PMID: 24051379.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  17. Yong KJ, Chai L, Tenen DG. Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N Engl J Med. 2013 09 19; 369(12):1171-2. PMID: 24047068.
    Citations: 16     Fields:    Translation:HumansAnimals
  18. He J, Zhang W, Zhou Q, Zhao T, Song Y, Chai L, Li Y. Low-expression of microRNA-107 inhibits cell apoptosis in glioma by upregulation of SALL4. Int J Biochem Cell Biol. 2013 Sep; 45(9):1962-73. PMID: 23811124.
    Citations:    
  19. Yong KJ, Gao C, Lim JS, Yan B, Yang H, Dimitrov T, Kawasaki A, Ong CW, Wong KF, Lee S, Ravikumar S, Srivastava S, Tian X, Poon RT, Fan ST, Luk JM, Dan YY, Salto-Tellez M, Chai L, Tenen DG. Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N Engl J Med. 2013 Jun 13; 368(24):2266-76. PMID: 23758232.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  20. Liang OD, Lu J, Nombela-Arrieta C, Zhong J, Zhao L, Pivarnik G, Mondal S, Chai L, Silberstein LE, Luo HR. Deficiency of lipid phosphatase SHIP enables long-term reconstitution of hematopoietic inductive bone marrow microenvironment. Dev Cell. 2013 May 28; 25(4):333-49. PMID: 23725762.
    Citations: 6     Fields:    Translation:AnimalsCells
  21. Gao C, Dimitrov T, Yong KJ, Tatetsu H, Jeong HW, Luo HR, Bradner JE, Tenen DG, Chai L. Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. Blood. 2013 Feb 21; 121(8):1413-21. PMID: 23287862.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  22. Gao C, Kong NR, Li A, Tatetu H, Ueno S, Yang Y, He J, Yang J, Ma Y, Kao GS, Tenen DG, Chai L. SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013 May; 53(5):1037-49. PMID: 22934838.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  23. Hobbs RM, Fagoonee S, Papa A, Webster K, Altruda F, Nishinakamura R, Chai L, Pandolfi PP. Functional antagonism between Sall4 and Plzf defines germline progenitors. Cell Stem Cell. 2012 Mar 02; 10(3):284-98. PMID: 22385656.
    Citations: 48     Fields:    Translation:AnimalsCells
  24. Lu J, Sun Y, Nombela-Arrieta C, Du KP, Park SY, Chai L, Walkley C, Luo HR, Silberstein LE. Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion. Exp Hematol. 2012 Apr; 40(4):307-17.e3. PMID: 22155722.
    Citations: 10     Fields:    Translation:AnimalsCells
  25. Chai L. The role of HSAL (SALL) genes in proliferation and differentiation in normal hematopoiesis and leukemogenesis. Transfusion. 2011 Nov; 51 Suppl 4:87S-93S. PMID: 22074632.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  26. Jeong HW, Cui W, Yang Y, Lu J, He J, Li A, Song D, Guo Y, Liu BH, Chai L. SALL4, a stem cell factor, affects the side population by regulation of the ATP-binding cassette drug transport genes. PLoS One. 2011 Apr 19; 6(4):e18372. PMID: 21526180.
    Citations: 27     Fields:    Translation:HumansCells
  27. Gao C, Kong NR, Chai L. The role of stem cell factor SALL4 in leukemogenesis. Crit Rev Oncog. 2011; 16(1-2):117-27. PMID: 22150312.
    Citations: 14     Fields:    Translation:HumansAnimals
  28. Yang J, Gao C, Chai L, Ma Y. A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells. PLoS One. 2010 May 21; 5(5):e10766. PMID: 20505821.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  29. Yu H, Li Y, Gao C, Fabien L, Jia Y, Lu J, Silberstein LE, Pinkus GS, Ye K, Chai L, Luo HR. Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN. Leukemia. 2010 May; 24(5):1077-80. PMID: 20220776.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  30. Lu J, Jeong HW, Jeong H, Kong N, Yang Y, Carroll J, Luo HR, Silberstein LE, Chai L. Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex. PLoS One. 2009; 4(5):e5577. PMID: 19440552.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  31. Le Y, Xu L, Lu J, Fang J, Nardi V, Chai L, Silberstein LE. FAK silencing inhibits leukemogenesis in BCR/ABL-transformed hematopoietic cells. Am J Hematol. 2009 May; 84(5):273-8. PMID: 19358301.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  32. Jia Y, Loison F, Hattori H, Li Y, Erneux C, Park SY, Gao C, Chai L, Silberstein LE, Schurmans S, Luo HR. Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4739-44. PMID: 18339802.
    Citations: 18     Fields:    Translation:AnimalsCells
  33. Cui W, Kong NR, Ma Y, Amin HM, Lai R, Chai L. Differential expression of the novel oncogene, SALL4, in lymphoma, plasma cell myeloma, and acute lymphoblastic leukemia. Mod Pathol. 2006 Dec; 19(12):1585-92. PMID: 16998462.
    Citations: 32     Fields:    Translation:HumansCells
  34. Zhang, J., Tam, W.L., Tong, G., Wu, Q.,Chan, H. Y., Soh, B.S., Lou, Y., Yang, J., Ma, Y., Chai, L., Ng, H.H., Lufkin, T., Robson, P., Lim, B. . Sall4 modulates embryonic stem cell pluripotency and early embryonic development by transcription regulation of Pou5f1. Nat Cell Bio. 2006; 8(10):1114-23.
  35. Ma Y, Cui W, Yang J, Qu J, Di C, Amin HM, Lai R, Ritz J, Krause DS, Chai L. SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood. 2006 Oct 15; 108(8):2726-35. PMID: 16763212.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  36. Chai L, Yang J, Di C, Cui W, Kawakami K, Lai R, Ma Y. Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development. J Biol Chem. 2006 Jul 14; 281(28):18918-26. PMID: 16670092.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  37. Chai, L., Cui, W., Yang, JC., Di, C., Amin, H., Ma, Y. . a novel oncogene induces myelodysplastic syndrome and acute myeloid leukemia via Wnt/beta-catenin pathway. Blood/Presentation at ASH. 2005; 106:397a.
  38. Chai, L., Cui, Ritz, J, Krause, DS., Ma, Y. The role of SALL4, a novel oncogene in leukemia stem cell. The HSCT stem cell symposium poster presentation. 2005.
  39. Chai, L, Ma YP. Targeting of SALL4 for the treatment and diagnosis of proliferative disorders associated with myelodysplastic syndrome (MDS). 2005.
  40. Cui, W., Ma, YP., Chai, L. Using Novel Oncogene SALL4 as a Diagnostic Marker for B-cell Acute Lymphoblastic Leukemia (B-ALL). 2nd IABMR (International association for biological and medical research) presentation. 2005.
  41. Chai, L. Krause, DS. Myelopoiesis is impaired in Sall2-null mice. Blood/Presentation at ASH, 2003. 2003; 102:334A.
  42. Herzog EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells. Blood. 2003 Nov 15; 102(10):3483-93. PMID: 12893756.
    Citations: 174     Fields:    Translation:HumansAnimalsCells
  43. Chai, L., Sweeney, J. . Interdiction of pre-procedure plasma in patients undergoing invasive procedures. Transfusion/Presentation at AABB, 2002. 2002.
  44. Pomper G, Chai L, Snyder E. Platelet Transfusion and Alternatives. Simon TL, Dzik WH, Snyder EL, Stowell CP, Strauss RG, editors. 2002; p232-47.
  45. Ma Y, Chai L, Cortez SC, Stopa EG, Steinhoff MM, Ford D, Morgan J, Maizel AL. SALL1 expression in the human pituitary-adrenal/gonadal axis. J Endocrinol. 2002 Jun; 173(3):437-48. PMID: 12065233.
    Citations: 8     Fields:    Translation:HumansCells
  46. Chai, L., Krause, D., Kouttab, N., and Maizel, A.L. Hsal 2, A Novel Homeobox Gene, With Two Alternative Promoters, Is Repressed by WT-1, and Is Differentially Expressed in Myelopoiesis and Leukemogenesis. Blood/Presentation at ASH 2001. 2001.
  47. Pomper, G., Chai, L., Champion, M., Neal, Z., and Snyder, E. . Incidence of Febrile and Allergic Reactions Following Introduction of Prestorage Universal Leukoreduction of Random Donor Platelets and Red Cells. Transfusion/Presentation for AABB 2001. 2001.
  48. Chai, L., Pomper, G., Ross, R., Neal, Z., Champion, M., and Snyder, E. Hemolytic Anemia and Liver Damage Induced by Prophylactic Use of Cefotetan. Transfusion/Presentation at AABB 2001. 2001.
  49. Safran H, Steinhoff M, Mangray S, Rathore R, King TC, Chai L, Berzein K, Moore T, Iannitti D, Reiss P, Pasquariello T, Akerman P, Quirk D, Mass R, Goldstein L, Tantravahi U. Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma. Am J Clin Oncol. 2001 Oct; 24(5):496-9. PMID: 11586103.
    Citations: 32     Fields:    Translation:Humans
  50. Ma Y, Li D, Chai L, Luciani AM, Ford D, Morgan J, Maizel AL. Cloning and characterization of two promoters for the human HSAL2 gene and their transcriptional repression by the Wilms tumor suppressor gene product. J Biol Chem. 2001 Dec 21; 276(51):48223-30. PMID: 11577094.
    Citations: 12     Fields:    Translation:HumansCells
  51. Ma Y, Singer DB, Gozman A, Ford D, Chai L, Steinhoff MM, Hansen K, Maizel AL. Hsal 1 is related to kidney and gonad development and is expressed in Wilms tumor. Pediatr Nephrol. 2001 Sep; 16(9):701-9. PMID: 11511981.
    Citations: 8     Fields:    Translation:HumansCells
  52. Chai, L. Sweeney, J. . Platelet Transfusion. 2001.
  53. Sweeney J, Chai L. . The Author’s Reply to University Leukoreduction of Cellular Blood Components. Am Clin Patholo. 2001; 116:778-779..
  54. Ma, Y., Chai, L., Steinhoff, M.M., Taylor, W., and Maizel, A.L. . Hsal 2 Is Expressed at Multiple Levels of the Reproductive Axis and Sex Hormone-producing Tumors. Mod. Patho. 2000; (13):73A..
  55. Chai, L., Ma, Y., Kouttab, N., and Maizel, A.L. . Level of Expression of A Novel Homeobox Gene, Hsal 2, Is Related to Cellular Lineage, Maturational Stage and Transformation. Blood. 2000; 96:4256.
  56. Mangray, S., Steinhoff, M.M., Chai, L., Safran, T., and King, T. . Her-2/neu Expression in Pancreatic Adenocarcinoma. Mod. Patho. 2000; (13):187A..
  57. Chai L, Pomper G, Snyder E. . Transfusion Medicine Topic Update: Transfusion Associated Graft-Versus-Host Disease and Irradiation of Blood Components. 2000.
  58. Ma, Y., Gozman, A., Chai, L., Steinhoff, M.M., Hansen, K., and Maizel, A.L. Identification of the Townes-Brocks Syndrome Gene Product and its Involvement of Kidney and Gonad Development. Mod. Patho. 2000; (13):106A.
  59. Chai, L., Hanna, I., Ginepp, D. . The Clear Cell Variant of Acinic cell Carcinoma Does exist: A review of Four Cases. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, & Endodonitics. 2000; 90(4):490.
  60. Cortez, S., Ma, Y., Chai, L., Stopa, E., Maizel, A.L. . Presence of Hsal 1, A Downstream Component of Hedgehog/TGF-beta Signals in Human Pituitary. Journal of Neuropathology and Experimental Neurology,. 2000; 59:452.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.