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Li Chai, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03CA184531 (CHAI, LI) Jul 6, 2015 - Jun 30, 2017
    Murine Models on SALL4 in Hepatocellular Carcinoma
    Role: Principal Investigator
  2. P01HL095489 (SILBERSTEIN, LESLIE ERIC) Apr 1, 2009 - Mar 31, 2021
    Molecular Mechanisms of Blood Cell Transfusion
    Role: Co-Principal Investigator
  3. R01HL092437 (CHAI, LI) Sep 22, 2008 - Aug 31, 2014
    Role: Principal Investigator
  4. K08DK063220 (CHAI, LI) Aug 1, 2003 - Jun 30, 2009
    Hsal 2, A Novel Homeobox Gene in Hematopoiesis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wang F, Gao C, Lu J, Tatetsu H, Williams DA, Müller LU, Cui W, Chai L. Leukemic survival factor SALL4 contributes to defective DNA damage repair. Oncogene. 2016 11 24; 35(47):6087-6095. PMID: 27132514.
    View in: PubMed
  2. Tatetsu H, Kong NR, Chong G, Amabile G, Tenen DG, Chai L. SALL4, the missing link between stem cells, development and cancer. Gene. 2016 Jun 15; 584(2):111-9. PMID: 26892498; PMCID: PMC4823161 [Available on 06/15/17].
  3. Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Sun Y, Zhu H, Chai L, Silberstein LE, Cheng T, Luo HR. Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis. Immunity. 2015 Jan 20; 42(1):159-71. PMID: 25579427; PMCID: PMC4303526.
  4. Ueno S, Lu J, He J, Li A, Zhang X, Ritz J, Silberstein LE, Chai L. Aberrant expression of SALL4 in acute B cell lymphoblastic leukemia: mechanism, function, and implication for a potential novel therapeutic target. Exp Hematol. 2014 Apr; 42(4):307-316.e8. PMID: 24463278; PMCID: PMC4135469.
  5. Wang F, Zhao W, Kong N, Cui W, Chai L. The next new target in leukemia: The embryonic stem cell gene SALL4. Mol Cell Oncol. 2014; 1(4):e969169. PMID: 25977939.
    View in: PubMed
  6. Liang OD, Lu J, Nombela-Arrieta C, Zhong J, Zhao L, Pivarnik G, Mondal S, Chai L, Silberstein LE, Luo HR. Deficiency of lipid phosphatase SHIP enables long-term reconstitution of hematopoietic inductive bone marrow microenvironment. Dev Cell. 2013 May 28; 25(4):333-49. PMID: 23725762; PMCID: PMC3673722.
  7. Chai L, Romero D, Kayatekin C, Akabayov B, Vlamakis H, Losick R, Kolter R. Isolation, characterization, and aggregation of a structured bacterial matrix precursor. J Biol Chem. 2013 Jun 14; 288(24):17559-68. PMID: 23632024; PMCID: PMC3682555.
  8. Gao C, Dimitrov T, Yong KJ, Tatetsu H, Jeong HW, Luo HR, Bradner JE, Tenen DG, Chai L. Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. Blood. 2013 Feb 21; 121(8):1413-21. PMID: 23287862; PMCID: PMC3578956.
  9. Rubinstein SM, Kolodkin-Gal I, McLoon A, Chai L, Kolter R, Losick R, Weitz DA. Osmotic pressure can regulate matrix gene expression in Bacillus subtilis. Mol Microbiol. 2012 Oct; 86(2):426-36. PMID: 22882172; PMCID: PMC3828655.
  10. Gao C, Kong NR, Li A, Tatetu H, Ueno S, Yang Y, He J, Yang J, Ma Y, Kao GS, Tenen DG, Chai L. SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013 May; 53(5):1037-49. PMID: 22934838; PMCID: PMC3653586.
  11. Kolodkin-Gal I, Cao S, Chai L, Böttcher T, Kolter R, Clardy J, Losick R. A self-produced trigger for biofilm disassembly that targets exopolysaccharide. Cell. 2012 Apr 27; 149(3):684-92. PMID: 22541437; PMCID: PMC3526955.
  12. Hobbs RM, Fagoonee S, Papa A, Webster K, Altruda F, Nishinakamura R, Chai L, Pandolfi PP. Functional antagonism between Sall4 and Plzf defines germline progenitors. Cell Stem Cell. 2012 Mar 02; 10(3):284-98. PMID: 22385656; PMCID: PMC3299297.
  13. Lu J, Sun Y, Nombela-Arrieta C, Du KP, Park SY, Chai L, Walkley C, Luo HR, Silberstein LE. Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion. Exp Hematol. 2012 Apr; 40(4):307-17.e3. PMID: 22155722; PMCID: PMC3307834.
  14. Chai L. The role of HSAL (SALL) genes in proliferation and differentiation in normal hematopoiesis and leukemogenesis. Transfusion. 2011 Nov; 51 Suppl 4:87S-93S. PMID: 22074632; PMCID: PMC3258526.
  15. Jeong HW, Cui W, Yang Y, Lu J, He J, Li A, Song D, Guo Y, Liu BH, Chai L. SALL4, a stem cell factor, affects the side population by regulation of the ATP-binding cassette drug transport genes. PLoS One. 2011 Apr 19; 6(4):e18372. PMID: 21526180; PMCID: PMC3079717.
  16. Gao C, Kong NR, Chai L. The role of stem cell factor SALL4 in leukemogenesis. Crit Rev Oncog. 2011; 16(1-2):117-27. PMID: 22150312; PMCID: PMC3238789.
  17. Lu J, Jeong HW, Jeong H, Kong N, Yang Y, Carroll J, Luo HR, Silberstein LE, Chai L. Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex. PLoS One. 2009; 4(5):e5577. PMID: 19440552; PMCID: PMC2679146.
  18. Le Y, Xu L, Lu J, Fang J, Nardi V, Chai L, Silberstein LE. FAK silencing inhibits leukemogenesis in BCR/ABL-transformed hematopoietic cells. Am J Hematol. 2009 May; 84(5):273-8. PMID: 19358301.
    View in: PubMed
  19. Jia Y, Loison F, Hattori H, Li Y, Erneux C, Park SY, Gao C, Chai L, Silberstein LE, Schurmans S, Luo HR. Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4739-44. PMID: 18339802; PMCID: PMC2290809.
  20. Mukai Y, Chai LL, Shaleh SR, Senoo S. Structure and development of free neuromasts in barramundi, Lates calcarifer (Block). Zoolog Sci. 2007 Aug; 24(8):829-35. PMID: 18217491.
    View in: PubMed
  21. Cui W, Kong NR, Ma Y, Amin HM, Lai R, Chai L. Differential expression of the novel oncogene, SALL4, in lymphoma, plasma cell myeloma, and acute lymphoblastic leukemia. Mod Pathol. 2006 Dec; 19(12):1585-92. PMID: 16998462.
    View in: PubMed
  22. Zhang, J., Tam, W.L., Tong, G., Wu, Q.,Chan, H. Y., Soh, B.S., Lou, Y., Yang, J., Ma, Y., Chai, L., Ng, H.H., Lufkin, T., Robson, P., Lim, B. . Sall4 modulates embryonic stem cell pluripotency and early embryonic development by transcription regulation of Pou5f1. Nat Cell Bio. 2006; 8(10):1114-23.
  23. Ma Y, Cui W, Yang J, Qu J, Di C, Amin HM, Lai R, Ritz J, Krause DS, Chai L. SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood. 2006 Oct 15; 108(8):2726-35. PMID: 16763212; PMCID: PMC1895586.
  24. Chai L, Yang J, Di C, Cui W, Kawakami K, Lai R, Ma Y. Transcriptional activation of the SALL1 by the human SIX1 homeodomain during kidney development. J Biol Chem. 2006 Jul 14; 281(28):18918-26. PMID: 16670092.
    View in: PubMed
  25. Chai, L., Cui, W., Yang, JC., Di, C., Amin, H., Ma, Y. . a novel oncogene induces myelodysplastic syndrome and acute myeloid leukemia via Wnt/beta-catenin pathway. Blood/Presentation at ASH. 2005; 106:397a.
  26. Chai, L., Cui, Ritz, J, Krause, DS., Ma, Y. The role of SALL4, a novel oncogene in leukemia stem cell. The HSCT stem cell symposium poster presentation. 2005.
  27. Chai, L, Ma YP. Targeting of SALL4 for the treatment and diagnosis of proliferative disorders associated with myelodysplastic syndrome (MDS). 2005.
  28. Cui, W., Ma, YP., Chai, L. Using Novel Oncogene SALL4 as a Diagnostic Marker for B-cell Acute Lymphoblastic Leukemia (B-ALL). 2nd IABMR (International association for biological and medical research) presentation. 2005.
  29. Chai, L. Krause, DS. Myelopoiesis is impaired in Sall2-null mice. Blood/Presentation at ASH, 2003. 2003; 102:334A.
  30. Herzog EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells. Blood. 2003 Nov 15; 102(10):3483-93. PMID: 12893756.
    View in: PubMed
  31. Chai, L., Sweeney, J. . Interdiction of pre-procedure plasma in patients undergoing invasive procedures. Transfusion/Presentation at AABB, 2002. 2002.
  32. Pomper G, Chai L, Snyder E. Platelet Transfusion and Alternatives. Simon TL, Dzik WH, Snyder EL, Stowell CP, Strauss RG, editors. 2002; p232-47.
  33. Ma Y, Chai L, Cortez SC, Stopa EG, Steinhoff MM, Ford D, Morgan J, Maizel AL. SALL1 expression in the human pituitary-adrenal/gonadal axis. J Endocrinol. 2002 Jun; 173(3):437-48. PMID: 12065233.
    View in: PubMed
  34. Chai, L., Krause, D., Kouttab, N., and Maizel, A.L. Hsal 2, A Novel Homeobox Gene, With Two Alternative Promoters, Is Repressed by WT-1, and Is Differentially Expressed in Myelopoiesis and Leukemogenesis. Blood/Presentation at ASH 2001. 2001.
  35. Pomper, G., Chai, L., Champion, M., Neal, Z., and Snyder, E. . Incidence of Febrile and Allergic Reactions Following Introduction of Prestorage Universal Leukoreduction of Random Donor Platelets and Red Cells. Transfusion/Presentation for AABB 2001. 2001.
  36. Chai, L., Pomper, G., Ross, R., Neal, Z., Champion, M., and Snyder, E. Hemolytic Anemia and Liver Damage Induced by Prophylactic Use of Cefotetan. Transfusion/Presentation at AABB 2001. 2001.
  37. Safran H, Steinhoff M, Mangray S, Rathore R, King TC, Chai L, Berzein K, Moore T, Iannitti D, Reiss P, Pasquariello T, Akerman P, Quirk D, Mass R, Goldstein L, Tantravahi U. Overexpression of the HER-2/neu oncogene in pancreatic adenocarcinoma. Am J Clin Oncol. 2001 Oct; 24(5):496-9. PMID: 11586103.
    View in: PubMed
  38. Ma Y, Li D, Chai L, Luciani AM, Ford D, Morgan J, Maizel AL. Cloning and characterization of two promoters for the human HSAL2 gene and their transcriptional repression by the Wilms tumor suppressor gene product. J Biol Chem. 2001 Dec 21; 276(51):48223-30. PMID: 11577094.
    View in: PubMed
  39. Ma Y, Singer DB, Gozman A, Ford D, Chai L, Steinhoff MM, Hansen K, Maizel AL. Hsal 1 is related to kidney and gonad development and is expressed in Wilms tumor. Pediatr Nephrol. 2001 Sep; 16(9):701-9. PMID: 11511981.
    View in: PubMed
  40. Chai, L. Sweeney, J. . Platelet Transfusion. 2001.
  41. Sweeney J, Chai L. . The Author’s Reply to University Leukoreduction of Cellular Blood Components. Am Clin Patholo. 2001; 116:778-779..
  42. Ma, Y., Chai, L., Steinhoff, M.M., Taylor, W., and Maizel, A.L. . Hsal 2 Is Expressed at Multiple Levels of the Reproductive Axis and Sex Hormone-producing Tumors. Mod. Patho. 2000; (13):73A..
  43. Chai, L., Ma, Y., Kouttab, N., and Maizel, A.L. . Level of Expression of A Novel Homeobox Gene, Hsal 2, Is Related to Cellular Lineage, Maturational Stage and Transformation. Blood. 2000; 96:4256.
  44. Mangray, S., Steinhoff, M.M., Chai, L., Safran, T., and King, T. . Her-2/neu Expression in Pancreatic Adenocarcinoma. Mod. Patho. 2000; (13):187A..
  45. Chai L, Pomper G, Snyder E. . Transfusion Medicine Topic Update: Transfusion Associated Graft-Versus-Host Disease and Irradiation of Blood Components. 2000.
  46. Ma, Y., Gozman, A., Chai, L., Steinhoff, M.M., Hansen, K., and Maizel, A.L. Identification of the Townes-Brocks Syndrome Gene Product and its Involvement of Kidney and Gonad Development. Mod. Patho. 2000; (13):106A.
  47. Chai, L., Hanna, I., Ginepp, D. . The Clear Cell Variant of Acinic cell Carcinoma Does exist: A review of Four Cases. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, & Endodonitics. 2000; 90(4):490.
  48. Cortez, S., Ma, Y., Chai, L., Stopa, E., Maizel, A.L. . Presence of Hsal 1, A Downstream Component of Hedgehog/TGF-beta Signals in Human Pituitary. Journal of Neuropathology and Experimental Neurology,. 2000; 59:452.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.