Harvard Catalyst Profiles

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Jonathan C. Kagan, PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI116550 (KAGAN, JONATHAN C) Dec 13, 2016 - Nov 30, 2020
    NIH/NIAID
    Characterization of the myddosome, a protein complex that controls TLR signaling
    Role: Principal Investigator
  2. R56AI113141 (KAGAN, JONATHAN C) Aug 1, 2014 - Jul 31, 2015
    NIH/NIAID
    Initiation and regulation of antibacterial innate immunity
    Role: Principal Investigator
  3. R56AI103082 (KAGAN, JONATHAN C) May 16, 2013 - Apr 30, 2014
    NIH/NIAID
    Defining non-transcriptional innate immune responses to bacterial endotoxin
    Role: Principal Investigator
  4. R01AI093589 (KAGAN, JONATHAN C) Mar 1, 2011 - Feb 28, 2021
    NIH/NIAID
    Initiation and Regulation of Antiviral Innate Immunity
    Role: Principal Investigator
  5. R00AI072955 (KAGAN, JONATHAN C) Dec 1, 2006 - Jan 31, 2011
    NIH/NIAID
    Cellular and molecular aspects of Toll-like receptor signal transduction.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rotjan RD, Sharp KH, Gauthier AE, Yelton R, Lopez EMB, Carilli J, Kagan JC, Urban-Rich J. Patterns, dynamics and consequences of microplastic ingestion by the temperate coral, Astrangia poculata. Proc Biol Sci. 2019 Jun 26; 286(1905):20190726. PMID: 31238843.
    Citations:    
  2. Barnett KC, Kagan JC. Lipids that directly regulate innate immune signal transduction. Innate Immun. 2019 Jun 10; 1753425919852695. PMID: 31180799.
    Citations:    
  3. Odendall C, Kagan JC. Host-Encoded Sensors of Bacteria: Our Windows into the Microbial World. Microbiol Spectr. 2019 May; 7(3). PMID: 31152521.
    Citations:    
  4. de Oliveira Mann CC, Orzalli MH, King DS, Kagan JC, Lee ASY, Kranzusch PJ. Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-?B Signaling Adaptation. Cell Rep. 2019 Apr 23; 27(4):1165-1175.e5. PMID: 31018131.
    Citations:    
  5. Tan Y, Kagan JC. Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility. Cell. 2019 Apr 04; 177(2):384-398.e11. PMID: 30853218.
    Citations:    
  6. Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ, Kagan JC. Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. Cell. 2019 Mar 07; 176(6):1432-1446.e11. PMID: 30827685.
    Citations:    
  7. Evavold CL, Kagan JC. Defying Death: The (W)hole Truth about the Fate of GSDMD Pores. Immunity. 2019 01 15; 50(1):15-17. PMID: 30650374.
    Citations:    Fields:    
  8. Shaw DK, Tate AT, Schneider DS, Levashina EA, Kagan JC, Pal U, Fikrig E, Pedra JHF. Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance. Trends Immunol. 2018 11; 39(11):862-873. PMID: 30301592.
    Citations:    Fields:    
  9. Chow J, Kagan JC. The Fly Way of Antiviral Resistance and Disease Tolerance. Adv Immunol. 2018; 140:59-93. PMID: 30366519.
    Citations:    Fields:    
  10. Orzalli MH, Smith A, Jurado KA, Iwasaki A, Garlick JA, Kagan JC. An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication. Mol Cell. 2018 09 06; 71(5):825-840.e6. PMID: 30100266.
    Citations:    Fields:    
  11. Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. Retraction Notice to: The Unfolded Protein Response Element IRE1a Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling. Cell Host Microbe. 2018 04 11; 23(4):571. PMID: 29649448.
    Citations: 1     Fields:    
  12. Franz KM, Neidermyer WJ, Tan YJ, Whelan SPJ, Kagan JC. STING-dependent translation inhibition restricts RNA virus replication. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):E2058-E2067. PMID: 29440426.
    Citations: 3     Fields:    Translation:AnimalsCells
  13. Tan Y, Kagan JC. Biochemical Isolation of the Myddosome from Murine Macrophages. Methods Mol Biol. 2018; 1714:79-95. PMID: 29177857.
    Citations:    Fields:    Translation:AnimalsCells
  14. Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC. The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Immunity. 2018 01 16; 48(1):35-44.e6. PMID: 29195811.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  15. Zanoni I, Tan Y, Di Gioia M, Springstead JR, Kagan JC. By Capturing Inflammatory Lipids Released from Dying Cells, the Receptor CD14 Induces Inflammasome-Dependent Phagocyte Hyperactivation. Immunity. 2017 10 17; 47(4):697-709.e3. PMID: 29045901.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  16. Evavold CL, Kagan JC. How Inflammasomes Inform Adaptive Immunity. J Mol Biol. 2018 01 19; 430(2):217-237. PMID: 28987733.
    Citations: 2     Fields:    
  17. Odendall C, Voak AA, Kagan JC. Type III IFNs Are Commonly Induced by Bacteria-Sensing TLRs and Reinforce Epithelial Barriers during Infection. J Immunol. 2017 11 01; 199(9):3270-3279. PMID: 28954888.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  18. Chow J, Márka Z, Bartos I, Márka S, Kagan JC. Environmental Stress Causes Lethal Neuro-Trauma during Asymptomatic Viral Infections. Cell Host Microbe. 2017 Jul 12; 22(1):48-60.e5. PMID: 28704652.
    Citations: 1     Fields:    Translation:AnimalsCells
  19. Orzalli MH, Kagan JC. Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection. Trends Cell Biol. 2017 11; 27(11):800-809. PMID: 28642032.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  20. Franz KM, Kagan JC. Innate Immune Receptors as Competitive Determinants of Cell Fate. Mol Cell. 2017 Jun 15; 66(6):750-760. PMID: 28622520.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  21. Kagan JC. Lipopolysaccharide Detection across the Kingdoms of Life. Trends Immunol. 2017 10; 38(10):696-704. PMID: 28551077.
    Citations: 3     Fields:    Translation:HumansAnimals
  22. Kieser KJ, Kagan JC. Multi-receptor detection of individual bacterial products by the innate immune system. Nat Rev Immunol. 2017 Jun; 17(6):376-390. PMID: 28461704.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  23. Odendall C, Kagan JC. Activation and pathogenic manipulation of the sensors of the innate immune system. Microbes Infect. 2017 Apr - May; 19(4-5):229-237. PMID: 28093320.
    Citations: 2     Fields:    Translation:HumansCells
  24. Tan Y, Kagan JC. Microbe-inducible trafficking pathways that control Toll-like receptor signaling. Traffic. 2017 01; 18(1):6-17. PMID: 27731905.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  25. Rosadini CV, Kagan JC. Early innate immune responses to bacterial LPS. Curr Opin Immunol. 2017 Feb; 44:14-19. PMID: 27842237.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  26. Guerrant RL, Leite AM, Pinkerton R, Medeiros PH, Cavalcante PA, DeBoer M, Kosek M, Duggan C, Gewirtz A, Kagan JC, Gauthier AE, Swann J, Mayneris-Perxachs J, Bolick DT, Maier EA, Guedes MM, Moore SR, Petri WA, Havt A, Lima IF, Prata MM, Michaleckyj JC, Scharf RJ, Sturgeon C, Fasano A, Lima AA. Biomarkers of Environmental Enteropathy, Inflammation, Stunting, and Impaired Growth in Children in Northeast Brazil. PLoS One. 2016; 11(9):e0158772. PMID: 27690129.
    Citations: 29     Fields:    
  27. Orzalli MH, Kagan JC. A one-protein signaling pathway in the innate immune system. Sci Immunol. 2016 Aug 19; 1(2):eaah6184. PMID: 28783697.
    Citations:    Fields:    
  28. Kagan JC. Editorial overview: Emerging concepts in host-virus interactions. Curr Opin Microbiol. 2016 08; 32:xii-xiii. PMID: 27426076.
    Citations:    Fields:    Translation:HumansAnimals
  29. Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, Silverman N, Gravallese EM, Kagan JC, Fitzgerald KA, Kastner DL, Golenbock DT, Bergo MO, Wang D. Control of the innate immune response by the mevalonate pathway. Nat Immunol. 2016 08; 17(8):922-9. PMID: 27270400.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  30. Magalhães AC, Ferreira AR, Gomes S, Vieira M, Gouveia A, Valença I, Islinger M, Nascimento R, Schrader M, Kagan JC, Ribeiro D. Peroxisomes are platforms for cytomegalovirus' evasion from the cellular immune response. Sci Rep. 2016 05 16; 6:26028. PMID: 27181750.
    Citations: 4     Fields:    Translation:HumansCells
  31. Kagan J, Giang DD, Iademarco MF, Phung VT, Lau CY, Quang NN. Assessing Clinical Research Capacity in Vietnam: A Framework for Strengthening Capability for Clinical Trials in Developing Countries. Public Health Rep. 2016 May-Jun; 131(3):396-403. PMID: 27252559.
    Citations:    Fields:    Translation:Humans
  32. Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado CA, Shao F, Wu H, Springstead JR, Kagan JC. An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells. Science. 2016 Jun 03; 352(6290):1232-6. PMID: 27103670.
    Citations: 43     Fields:    Translation:AnimalsCells
  33. Ferreira AR, Magalhães AC, Camões F, Gouveia A, Vieira M, Kagan JC, Ribeiro D. Hepatitis C virus NS3-4A inhibits the peroxisomal MAVS-dependent antiviral signalling response. J Cell Mol Med. 2016 Apr; 20(4):750-7. PMID: 26865163.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  34. Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Philip NH, Brodsky IE, Mecsas J, Kagan JC. A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4. Cell Host Microbe. 2015 Dec 09; 18(6):682-93. PMID: 26651944.
    Citations: 9     Fields:    Translation:AnimalsCells
  35. Tan Y, Zanoni I, Cullen TW, Goodman AL, Kagan JC. Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria. Immunity. 2015 Nov 17; 43(5):909-22. PMID: 26546281.
    Citations: 18     Fields:    Translation:HumansCells
  36. Chow J, Franz KM, Kagan JC. PRRs are watching you: Localization of innate sensing and signaling regulators. Virology. 2015 May; 479-480:104-9. PMID: 25800355.
    Citations: 23     Fields:    Translation:Cells
  37. Odendall C, Kagan JC. The unique regulation and functions of type III interferons in antiviral immunity. Curr Opin Virol. 2015 Jun; 12:47-52. PMID: 25771505.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  38. Rosadini CV, Kagan JC. Microbial strategies for antagonizing Toll-like-receptor signal transduction. Curr Opin Immunol. 2015 Feb; 32:61-70. PMID: 25615700.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  39. Brubaker SW, Bonham KS, Zanoni I, Kagan JC. Innate immune pattern recognition: a cell biological perspective. Annu Rev Immunol. 2015; 33:257-90. PMID: 25581309.
    Citations: 152     Fields:    Translation:HumansAnimalsCells
  40. Gwadz M, Cleland CM, Belkin M, Ritchie A, Leonard N, Riedel M, Banfield A, Colon P, Elharrar V, Kagan J, Mildvan D. ACT2 peer-driven intervention increases enrollment into HIV/AIDS medical studies among African Americans/Blacks and Hispanics: A cluster randomized controlled trial. AIDS Behav. 2014 Dec; 18(12):2409-22. PMID: 24961193.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  41. Kagan JC, Barton GM. Emerging principles governing signal transduction by pattern-recognition receptors. Cold Spring Harb Perspect Biol. 2014 Nov 13; 7(3):a016253. PMID: 25395297.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  42. Kagan JC, Magupalli VG, Wu H. SMOCs: supramolecular organizing centres that control innate immunity. Nat Rev Immunol. 2014 12; 14(12):821-6. PMID: 25359439.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  43. Kagan JC. Common mechanisms activate plant guard receptors and TLR4. Trends Immunol. 2014 Oct; 35(10):454-6. PMID: 25224694.
    Citations: 2     Fields:    Translation:Animals
  44. Teigler JE, Kagan JC, Barouch DH. Late endosomal trafficking of alternative serotype adenovirus vaccine vectors augments antiviral innate immunity. J Virol. 2014 Sep; 88(18):10354-63. PMID: 24991003.
    Citations: 15     Fields:    Translation:HumansCells
  45. Odendall C, Dixit E, Stavru F, Bierne H, Franz KM, Durbin AF, Boulant S, Gehrke L, Cossart P, Kagan JC. Diverse intracellular pathogens activate type III interferon expression from peroxisomes. Nat Immunol. 2014 Aug; 15(8):717-26. PMID: 24952503.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  46. Bonham KS, Kagan JC. Endosomes as platforms for NOD-like receptor signaling. Cell Host Microbe. 2014 May 14; 15(5):523-5. PMID: 24832447.
    Citations: 5     Fields:    Translation:HumansCells
  47. Tan Y, Kagan JC. A cross-disciplinary perspective on the innate immune responses to bacterial lipopolysaccharide. Mol Cell. 2014 Apr 24; 54(2):212-23. PMID: 24766885.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  48. Brubaker SW, Gauthier AE, Mills EW, Ingolia NT, Kagan JC. A bicistronic MAVS transcript highlights a class of truncated variants in antiviral immunity. Cell. 2014 Feb 13; 156(4):800-11. PMID: 24529381.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  49. Bonham KS, Orzalli MH, Hayashi K, Wolf AI, Glanemann C, Weninger W, Iwasaki A, Knipe DM, Kagan JC. A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction. Cell. 2014 Feb 13; 156(4):705-16. PMID: 24529375.
    Citations: 57     Fields:    Translation:AnimalsCells
  50. Franz KM, Kagan JC. Finding a needle in a haystack of needles - a productive hunt for interferon stimulated genes with antiviral activity. Immunol Cell Biol. 2014 Mar; 92(3):205-7. PMID: 24418815.
    Citations:    Fields:    Translation:HumansAnimals
  51. Kagan JC. Immunology. Sensing endotoxins from within. Science. 2013 Sep 13; 341(6151):1184-5. PMID: 24031006.
    Citations: 3     Fields:    Translation:AnimalsCells
  52. Kagan JC, Horng T. NLRP3 inflammasome activation: CD36 serves double duty. Nat Immunol. 2013 Aug; 14(8):772-4. PMID: 23867926.
    Citations: 4     Fields:    Translation:Animals
  53. Kagan JC. Recognition for an innate explorer. Cell. 2013 Jul 18; 154(2):261-4. PMID: 23870114.
    Citations:    Fields:    Translation:HumansAnimalsCells
  54. Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI. The unfolded protein response element IRE1a senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe. 2013 May 15; 13(5):558-569. PMID: 23684307.
    Citations: 47     Fields:    Translation:HumansCells
  55. Odendall C, Kagan JC. Peroxisomes and the antiviral responses of mammalian cells. Subcell Biochem. 2013; 69:67-75. PMID: 23821143.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  56. Dixit E, Kagan JC. Intracellular pathogen detection by RIG-I-like receptors. Adv Immunol. 2013; 117:99-125. PMID: 23611287.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  57. Kagan JC. Signaling organelles of the innate immune system. Cell. 2012 Dec 07; 151(6):1168-78. PMID: 23217704.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  58. Velupillai P, Sung CK, Andrews E, Moran J, Beier D, Kagan J, Benjamin T. Polymorphisms in toll-like receptor 4 underlie susceptibility to tumor induction by the mouse polyomavirus. J Virol. 2012 Nov; 86(21):11541-7. PMID: 22896604.
    Citations: 3     Fields:    Translation:AnimalsCells
  59. Kagan JC. Defining the subcellular sites of innate immune signal transduction. Trends Immunol. 2012 Sep; 33(9):442-8. PMID: 22817912.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  60. Kagan JC, Iwasaki A. Phagosome as the organelle linking innate and adaptive immunity. Traffic. 2012 Aug; 13(8):1053-61. PMID: 22577865.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  61. Marek LR, Kagan JC. Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila. Immunity. 2012 Apr 20; 36(4):612-22. PMID: 22464168.
    Citations: 18     Fields:    Translation:AnimalsCells
  62. Zanoni I, Ostuni R, Marek LR, Barresi S, Barbalat R, Barton GM, Granucci F, Kagan JC. CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell. 2011 Nov 11; 147(4):868-80. PMID: 22078883.
    Citations: 204     Fields:    Translation:AnimalsCells
  63. Schwartz CE, Kunwar PS, Greve DN, Kagan J, Snidman NC, Bloch RB. A phenotype of early infancy predicts reactivity of the amygdala in male adults. Mol Psychiatry. 2012 Oct; 17(10):1042-50. PMID: 21894151.
    Citations: 18     Fields:    Translation:Humans
  64. Edison N, Zuri D, Maniv I, Bornstein B, Lev T, Gottfried Y, Kemeny S, Garcia-Fernandez M, Kagan J, Larisch S. The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo. Cell Death Differ. 2012 Feb; 19(2):356-68. PMID: 21869827.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  65. Wang S, Villablanca EJ, De Calisto J, Gomes DC, Nguyen DD, Mizoguchi E, Kagan JC, Reinecker HC, Hacohen N, Nagler C, Xavier RJ, Rossi-Bergmann B, Chen YB, Blomhoff R, Snapper SB, Mora JR. MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. J Immunol. 2011 Jul 01; 187(1):141-50. PMID: 21646294.
    Citations: 30     Fields:    Translation:AnimalsCells
  66. Marek LR, Kagan JC. Deciphering the function of nucleic acid sensing TLRs one regulatory step at a time. Front Biosci (Landmark Ed). 2011 Jun 01; 16:2060-8. PMID: 21622162.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  67. Wang L, Trebicka E, Fu Y, Waggoner L, Akira S, Fitzgerald KA, Kagan JC, Cherayil BJ. Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM. J Innate Immun. 2011; 3(5):437-46. PMID: 21494017.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  68. Liao AP, Salajegheh M, Nazareno R, Kagan JC, Jubin RG, Greenberg SA. Interferon ß is associated with type 1 interferon-inducible gene expression in dermatomyositis. Ann Rheum Dis. 2011 May; 70(5):831-6. PMID: 21177291.
    Citations: 16     Fields:    Translation:HumansCells
  69. Kagan JC. Recycling endosomes and TLR signaling--the Rab11 GTPase leads the way. Immunity. 2010 Oct 29; 33(4):578-80. PMID: 21029967.
    Citations: 1     Fields:    
  70. Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC. Peroxisomes are signaling platforms for antiviral innate immunity. Cell. 2010 May 14; 141(4):668-81. PMID: 20451243.
    Citations: 231     Fields:    Translation:HumansAnimalsCells
  71. Kagan JC. "Complementing" toll signaling. Sci Signal. 2010 May 04; 3(120):pe15. PMID: 20442416.
    Citations: 6     Fields:    Translation:HumansCells
  72. Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ. Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J Clin Invest. 2009 Nov; 119(11):3322-8. PMID: 19809161.
    Citations: 58     Fields:    Translation:AnimalsCells
  73. Barton GM, Kagan JC. A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat Rev Immunol. 2009 Aug; 9(8):535-42. PMID: 19556980.
    Citations: 231     Fields:    Translation:HumansAnimalsCells
  74. Kagan JC, Su T, Horng T, Chow A, Akira S, Medzhitov R. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol. 2008 Apr; 9(4):361-8. PMID: 18297073.
    Citations: 406     Fields:    Translation:HumansAnimalsCells
  75. Kagan JC, Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell. 2006 Jun 02; 125(5):943-55. PMID: 16751103.
    Citations: 249     Fields:    Translation:HumansAnimalsCells
  76. Barton GM, Kagan JC, Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol. 2006 Jan; 7(1):49-56. PMID: 16341217.
    Citations: 166     Fields:    Translation:Animals
  77. Lambert JS, Moye J, Plaeger SF, Stiehm ER, Bethel J, Mofenson LM, Mathieson B, Kagan J, Rosenblatt H, Paxton H, Suter H, Landay A. Association of selected phenotypic markers of lymphocyte activation and differentiation with perinatal human immunodeficiency virus transmission and infant infection. Clin Diagn Lab Immunol. 2005 May; 12(5):622-31. PMID: 15879023.
    Citations: 2     Fields:    Translation:HumansCells
  78. Mildvan D, Spritzler J, Grossberg SE, Fahey JL, Johnston DM, Schock BR, Kagan J. Serum neopterin, an immune activation marker, independently predicts disease progression in advanced HIV-1 infection. Clin Infect Dis. 2005 Mar 15; 40(6):853-8. PMID: 15736019.
    Citations: 26     Fields:    Translation:Humans
  79. Kagan JC, Murata T, Roy CR. Analysis of Rab1 recruitment to vacuoles containing Legionella pneumophila. Methods Enzymol. 2005; 403:71-81. PMID: 16473578.
    Citations: 6     Fields:    Translation:AnimalsCells
  80. Nagai H, Cambronne ED, Kagan JC, Amor JC, Kahn RA, Roy CR. A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):826-31. PMID: 15613486.
    Citations: 120     Fields:    Translation:AnimalsCells
  81. Mildvan D, Bosch RJ, Kim RS, Spritzler J, Haas DW, Kuritzkes D, Kagan J, Nokta M, DeGruttola V, Moreno M, Landay A. Immunophenotypic markers and antiretroviral therapy (IMART): T cell activation and maturation help predict treatment response. J Infect Dis. 2004 May 15; 189(10):1811-20. PMID: 15122517.
    Citations: 14     Fields:    Translation:HumansCellsCTClinical Trials
  82. Kagan JC, Stein MP, Pypaert M, Roy CR. Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle. J Exp Med. 2004 May 03; 199(9):1201-11. PMID: 15117975.
    Citations: 105     Fields:    Translation:AnimalsCells
  83. Guignot J, Caron E, Beuzón C, Bucci C, Kagan J, Roy C, Holden DW. Microtubule motors control membrane dynamics of Salmonella-containing vacuoles. J Cell Sci. 2004 Mar 01; 117(Pt 7):1033-45. PMID: 14970261.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  84. Spritzler J, Mildvan D, Russo A, Asthana D, Livnat D, Schock B, Kagan J, Landay A, Haas DW. Can immune markers predict subsequent discordance between immunologic and virologic responses to antiretroviral therapy? Adult AIDS Clinical Trials Group. Clin Infect Dis. 2003 Aug 15; 37(4):551-8. PMID: 12905140.
    Citations: 5     Fields:    Translation:HumansCells
  85. Jonathan C. Kagan. Cellular and Molecular Aspects of Legionella pneumophila transport to the endoplasmic reticulum. 2003.
  86. Kagan JC, Roy CR. Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites. Nat Cell Biol. 2002 Dec; 4(12):945-54. PMID: 12447391.
    Citations: 159     Fields:    Translation:AnimalsCells
  87. Nagai H, Kagan JC, Zhu X, Kahn RA, Roy CR. A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes. Science. 2002 Jan 25; 295(5555):679-82. PMID: 11809974.
    Citations: 205     Fields:    Translation:HumansAnimalsCells
  88. Biederman J, Hirshfeld-Becker DR, Rosenbaum JF, Hérot C, Friedman D, Snidman N, Kagan J, Faraone SV. Further evidence of association between behavioral inhibition and social anxiety in children. Am J Psychiatry. 2001 Oct; 158(10):1673-9. PMID: 11579001.
    Citations: 127     Fields:    Translation:Humans
  89. Spencer T, Biederman J, Wilens T, Faraone S, Prince J, Gerard K, Doyle R, Parekh A, Kagan J, Bearman SK. Efficacy of a mixed amphetamine salts compound in adults with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry. 2001 Aug; 58(8):775-82. PMID: 11483144.
    Citations: 41     Fields:    Translation:HumansCTClinical Trials
  90. Kagan J. Biological constraint, cultural variety, and psychological structures. Ann N Y Acad Sci. 2001 May; 935:177-90. PMID: 11411164.
    Citations:    Fields:    Translation:Humans
  91. Smoller JW, Rosenbaum JF, Biederman J, Susswein LS, Kennedy J, Kagan J, Snidman N, Laird N, Tsuang MT, Faraone SV, Schwarz A, Slaugenhaupt SA. Genetic association analysis of behavioral inhibition using candidate loci from mouse models. Am J Med Genet. 2001 Apr 08; 105(3):226-35. PMID: 11353440.
    Citations: 13     Fields:    Translation:HumansAnimals
  92. Spencer TJ, Biederman J, Faraone S, Mick E, Coffey B, Geller D, Kagan J, Bearman SK, Wilens T. Impact of tic disorders on ADHD outcome across the life cycle: findings from a large group of adults with and without ADHD. Am J Psychiatry. 2001 Apr; 158(4):611-7. PMID: 11282697.
    Citations: 12     Fields:    Translation:Humans
  93. Rosenbaum JF, Biederman J, Hirshfeld-Becker DR, Kagan J, Snidman N, Friedman D, Nineberg A, Gallery DJ, Faraone SV. A controlled study of behavioral inhibition in children of parents with panic disorder and depression. Am J Psychiatry. 2000 Dec; 157(12):2002-10. PMID: 11097967.
    Citations: 34     Fields:    Translation:Humans
  94. Coers J, Kagan JC, Matthews M, Nagai H, Zuckman DM, Roy CR. Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth. Mol Microbiol. 2000 Nov; 38(4):719-36. PMID: 11115108.
    Citations: 64     Fields:    Translation:HumansCells
  95. Schwartz CE, Snidman N, Kagan J. Adolescent social anxiety as an outcome of inhibited temperament in childhood. J Am Acad Child Adolesc Psychiatry. 1999 Aug; 38(8):1008-15. PMID: 10434493.
    Citations: 149     Fields:    Translation:Humans
  96. Grillon C, Merikangas KR, Dierker L, Snidman N, Arriaga RI, Kagan J, Donzella B, Dikel T, Nelson C. Startle potentiation by threat of aversive stimuli and darkness in adolescents: a multi-site study. Int J Psychophysiol. 1999 Apr; 32(1):63-73. PMID: 10192009.
    Citations: 16     Fields:    Translation:HumansCTClinical Trials
  97. Lieberman J, Skolnik PR, Parkerson GR, Fabry JA, Landry B, Bethel J, Kagan J. Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients. Blood. 1997 Sep 15; 90(6):2196-206. PMID: 9310470.
    Citations: 17     Fields:    Translation:HumansCellsCTClinical Trials
  98. Goodman E, Amick BC, Rezendes MO, Tarlov AR, Rogers WH, Kagan J. Influences of gender and social class on adolescents' perceptions of health. Arch Pediatr Adolesc Med. 1997 Sep; 151(9):899-904. PMID: 9308867.
    Citations: 7     Fields:    Translation:Humans
  99. Gortmaker SL, Kagan J, Caspi A, Silva PA. Daylength during pregnancy and shyness in children: results from northern and southern hemispheres. Dev Psychobiol. 1997 Sep; 31(2):107-14. PMID: 9298636.
    Citations: 7     Fields:    Translation:Humans
  100. Mildvan D, Landay A, De Gruttola V, Machado SG, Kagan J. An approach to the validation of markers for use in AIDS clinical trials. Clin Infect Dis. 1997 May; 24(5):764-74. PMID: 9142767.
    Citations: 15     Fields:    Translation:Humans
  101. Nicholson J, Kidd P, Mandy F, Livnat D, Kagan J. Three-color supplement to the NIAID DAIDS guideline for flow cytometric immunophenotyping. Cytometry. 1996 Sep 15; 26(3):227-30. PMID: 8889396.
    Citations: 17     Fields:    Translation:HumansCells
  102. Valentine FT, Kundu S, Haslett PA, Katzenstein D, Beckett L, Spino C, Borucki M, Vasquez M, Smith G, Korvick J, Kagan J, Merigan TC. A randomized, placebo-controlled study of the immunogenicity of human immunodeficiency virus (HIV) rgp160 vaccine in HIV-infected subjects with > or = 400/mm3 CD4 T lymphocytes (AIDS Clinical Trials Group Protocol 137). J Infect Dis. 1996 Jun; 173(6):1336-46. PMID: 8648205.
    Citations: 9     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  103. Connelly MC, Knight M, Giorgi JV, Kagan J, Landay AL, Parker JW, Page E, Spino C, Wilkening C, Mercolino TJ. Standardization of absolute CD4+ lymphocyte counts across laboratories: an evaluation of the Ortho CytoronAbsolute flow cytometry system on normal donors. Cytometry. 1995 Sep 15; 22(3):200-10. PMID: 8556951.
    Citations: 7     Fields:    Translation:Humans
  104. Landay AL, Brambilla D, Pitt J, Hillyer G, Golenbock D, Moye J, Landesman S, Kagan J. Interlaboratory variability of CD8 subset measurements by flow cytometry and its applications to multicenter clinical trials. NAID/NICHD Women and Infants Transmission Study Group. Clin Diagn Lab Immunol. 1995 Jul; 2(4):462-8. PMID: 7583925.
    Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
  105. Biederman J, Rosenbaum JF, Bolduc-Murphy EA, Faraone SV, Chaloff J, Hirshfeld DR, Kagan J. A 3-year follow-up of children with and without behavioral inhibition. J Am Acad Child Adolesc Psychiatry. 1993 Jul; 32(4):814-21. PMID: 8340303.
    Citations: 71     Fields:    Translation:Humans
  106. Rosenbaum JF, Biederman J, Bolduc-Murphy EA, Faraone SV, Chaloff J, Hirshfeld DR, Kagan J. Behavioral inhibition in childhood: a risk factor for anxiety disorders. Harv Rev Psychiatry. 1993 May-Jun; 1(1):2-16. PMID: 9384823.
    Citations: 41     Fields:    Translation:Humans
  107. Kagan J, Gelman R, Waxdal M, Kidd P. NIAID Division of AIDS flow cytometry quality assessment program. Ann N Y Acad Sci. 1993 Mar 20; 677:50-2. PMID: 8494245.
    Citations: 4     Fields:    Translation:HumansCells
  108. Gelman R, Cheng SC, Kidd P, Waxdal M, Kagan J. Assessment of the effects of instrumentation, monoclonal antibody, and fluorochrome on flow cytometric immunophenotyping: a report based on 2 years of the NIAID DAIDS flow cytometry quality assessment program. Clin Immunol Immunopathol. 1993 Feb; 66(2):150-62. PMID: 7680972.
    Citations: 14     Fields:    Translation:Humans
  109. Rosenbaum JF, Biederman J, Bolduc EA, Hirshfeld DR, Faraone SV, Kagan J. Comorbidity of parental anxiety disorders as risk for childhood-onset anxiety in inhibited children. Am J Psychiatry. 1992 Apr; 149(4):475-81. PMID: 1554032.
    Citations: 10     Fields:    Translation:Humans
  110. Hirshfeld DR, Rosenbaum JF, Biederman J, Bolduc EA, Faraone SV, Snidman N, Reznick JS, Kagan J. Stable behavioral inhibition and its association with anxiety disorder. J Am Acad Child Adolesc Psychiatry. 1992 Jan; 31(1):103-11. PMID: 1537760.
    Citations: 96     Fields:    Translation:Humans
  111. Rosenbaum JF, Biederman J, Hirshfeld DR, Bolduc EA, Faraone SV, Kagan J, Snidman N, Reznick JS. Further evidence of an association between behavioral inhibition and anxiety disorders: results from a family study of children from a non-clinical sample. J Psychiatr Res. 1991; 25(1-2):49-65. PMID: 2027095.
    Citations: 26     Fields:    Translation:Humans
  112. Kris RM, South V, Saltzman A, Felder S, Ricca GA, Jaye M, Huebner K, Kagan J, Croce CM, Schlessinger J. Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis. Cell Growth Differ. 1991 Jan; 2(1):15-22. PMID: 1848773.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  113. Bell IR, Jasnoski ML, Kagan J, King DS. Depression and allergies: survey of a nonclinical population. Psychother Psychosom. 1991; 55(1):24-31. PMID: 1866437.
    Citations:    
  114. Bell IR, Jasnoski ML, Kagan J, King DS. Is allergic rhinitis more frequent in young adults with extreme shyness? A preliminary survey. Psychosom Med. 1990 Sep-Oct; 52(5):517-25. PMID: 2247557.
    Citations:    
  115. Kozbor D, Cassatella MA, Lessin S, Kagan J, Finver S, Faust J, Trinchieri G, Croce CM. Expression and function of gamma delta- and alpha beta-T cell receptor heterodimers on human somatic T cell hybrids. J Immunol. 1990 May 15; 144(10):3677-83. PMID: 1692058.
    Citations: 3     Fields:    Translation:HumansCells
  116. Biederman J, Rosenbaum JF, Hirshfeld DR, Faraone SV, Bolduc EA, Gersten M, Meminger SR, Kagan J, Snidman N, Reznick JS. Psychiatric correlates of behavioral inhibition in young children of parents with and without psychiatric disorders. Arch Gen Psychiatry. 1990 Jan; 47(1):21-6. PMID: 2294852.
    Citations: 57     Fields:    Translation:Humans
  117. Rosenbaum JF, Biederman J, Gersten M, Hirshfeld DR, Meminger SR, Herman JB, Kagan J, Reznick JS, Snidman N. Behavioral inhibition in children of parents with panic disorder and agoraphobia. A controlled study. Arch Gen Psychiatry. 1988 May; 45(5):463-70. PMID: 3358645.
    Citations: 34     Fields:    Translation:Humans
  118. Azar Y, Falek PR, Kagan J, Ben-Sasson SZ. In vivo activity of affinity-purified helper factor from antigen-specific helper clone. J Immunol. 1985 Mar; 134(3):1717-22. PMID: 2578517.
    Citations:    Fields:    Translation:AnimalsCells
  119. Ben-Sasson SZ, Kagan J. In vitro selection of murine antigen-specific T-lymphocytes. I. Description of selection procedure. J Immunol Methods. 1981; 42(3):291-304. PMID: 6169763.
    Citations:    
  120. Ben-Sasson SZ, Kagan J. Antigen-induced proliferation of murine T-lymphocytes in vitro. II. The effect of different macrophage populations on the antigen-induced proliferative response. J Immunol Methods. 1981; 41(3):321-31. PMID: 6971903.
    Citations:    
  121. Kagan J, Ben-Sasson SZ. Antigen-induced proliferation of murine T-lymphocytes in vitro. I. Characterization of the lymphocyte culture system. J Immunol Methods. 1980; 37(1):15-27. PMID: 6968800.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.