Harvard Catalyst Profiles

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Leigh Robert Hochberg, Ph.D., M.D.

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Overview

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. I50RX002864 (HOCHBERG, LEIGH R) Jun 1, 2018 - May 31, 2023
    VA
    Center for Neurorestoration and Neurotechnology
    Role: Principal Investigator
  2. IS1BX004387 (HOCHBERG, LEIGH R) Jan 1, 2018 - Sep 30, 2018
    VA
    ShEEP Request to upgrade the InMotion Upper Extremity Interactive Therapy System
    Role: Principal Investigator
  3. I01RX002295 (HOCHBERG, LEIGH R) Aug 1, 2017 - Jul 31, 2021
    VA
    BrainGate: Robust Neural Decoding for Veterans with ALS
    Role: Principal Investigator
  4. UH2NS095548 (HOCHBERG, LEIGH R) Sep 30, 2015 - Jun 30, 2019
    NIH/NINDS
    High-Bandwidth Wireless Interfaces for Continuous Human Intracortical Recording
    Role: Principal Investigator
  5. R01DC009899 (HOCHBERG, LEIGH R) Sep 1, 2009 - Jul 31, 2017
    NIH/NIDCD
    Restoring Communication with an Intracortical Neural Interface System
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Willett FR, Young DR, Murphy BA, Memberg WD, Blabe CH, Pandarinath C, Stavisky SD, Rezaii P, Saab J, Walter BL, Sweet JA, Miller JP, Henderson JM, Shenoy KV, Simeral JD, Jarosiewicz B, Hochberg LR, Kirsch RF, Bolu Ajiboye A. Principled BCI Decoder Design and Parameter Selection Using a Feedback Control Model. Sci Rep. 2019 Jun 20; 9(1):8881. PMID: 31222030.
    Citations:    
  2. Park YS, Cosgrove R, Madsen JR, Eskandar EN, Hochberg LR, Cash SS, Truccolo W. Early Detection of Human Epileptic Seizures Based on Intracortical Microelectrode Array Signals. IEEE Trans Biomed Eng. 2019 Jun 06. PMID: 31180831.
    Citations:    
  3. Stavisky SD, Kao JC, Nuyujukian P, Pandarinath C, Blabe C, Ryu SI, Hochberg LR, Henderson JM, Shenoy KV. Publisher Correction: Brain-machine interface cursor position only weakly affects monkey and human motor cortical activity in the absence of arm movements. Sci Rep. 2019 Mar 28; 9(1):5528. PMID: 30918269.
    Citations:    
  4. Milekovic T, Bacher D, Sarma AA, Simeral JD, Saab J, Pandarinath C, Yvert B, Sorice BL, Blabe C, Oakley EM, Tringale KR, Eskandar E, Cash SS, Shenoy KV, Henderson JM, Hochberg LR, Donoghue JP. Volitional control of single-electrode high gamma local field potentials by people with paralysis. J Neurophysiol. 2019 Apr 01; 121(4):1428-1450. PMID: 30785814.
    Citations:    
  5. Young D, Willett F, Memberg WD, Murphy B, Rezaii P, Walter B, Sweet J, Miller J, Shenoy KV, Hochberg LR, Kirsch RF, Ajiboye AB. Closed-loop cortical control of virtual reach and posture using Cartesian and joint velocity commands. J Neural Eng. 2019 Apr; 16(2):026011. PMID: 30523839.
    Citations:    Fields:    
  6. Nuyujukian P, Albites Sanabria J, Saab J, Pandarinath C, Jarosiewicz B, Blabe CH, Franco B, Mernoff ST, Eskandar EN, Simeral JD, Hochberg LR, Shenoy KV, Henderson JM. Cortical control of a tablet computer by people with paralysis. PLoS One. 2018; 13(11):e0204566. PMID: 30462658.
    Citations:    Fields:    
  7. Vargas-Irwin CE, Feldman JM, King B, Simeral JD, Sorice BL, Oakley EM, Cash SS, Eskandar EN, Friehs GM, Hochberg LR, Donoghue JP. Watch, Imagine, Attempt: Motor Cortex Single-Unit Activity Reveals Context-Dependent Movement Encoding in Humans With Tetraplegia. Front Hum Neurosci. 2018; 12:450. PMID: 30524258.
    Citations:    
  8. Stavisky SD, Kao JC, Nuyujukian P, Pandarinath C, Blabe C, Ryu SI, Hochberg LR, Henderson JM, Shenoy KV. Brain-machine interface cursor position only weakly affects monkey and human motor cortical activity in the absence of arm movements. Sci Rep. 2018 Nov 05; 8(1):16357. PMID: 30397281.
    Citations:    Fields:    
  9. Pandarinath C, O'Shea DJ, Collins J, Jozefowicz R, Stavisky SD, Kao JC, Trautmann EM, Kaufman MT, Ryu SI, Hochberg LR, Henderson JM, Shenoy KV, Abbott LF, Sussillo D. Inferring single-trial neural population dynamics using sequential auto-encoders. Nat Methods. 2018 10; 15(10):805-815. PMID: 30224673.
    Citations: 2     Fields:    
  10. Brandman DM, Burkhart MC, Kelemen J, Franco B, Harrison MT, Hochberg LR. Robust Closed-Loop Control of a Cursor in a Person with Tetraplegia using Gaussian Process Regression. Neural Comput. 2018 Sep 14; 1-23. PMID: 30216140.
    Citations:    Fields:    
  11. Stavisky SD, Rezaii P, Willett FR, Hochberg LR, Shenoy KV, Henderson JM. Decoding Speech from Intracortical Multielectrode Arrays in Dorsal "Arm/Hand Areas" of Human Motor Cortex. Conf Proc IEEE Eng Med Biol Soc. 2018 07; 2018:93-97. PMID: 30440349.
    Citations:    Fields:    
  12. Birbaumer N, Hochberg LR. A useful communication in brain-computer interfaces. Neurology. 2018 Jul 17; 91(3):109-110. PMID: 29950438.
    Citations:    Fields:    
  13. Chatelle C, Spencer CA, Cash SS, Hochberg LR, Edlow BL. Feasibility of an EEG-based brain-computer interface in the intensive care unit. Clin Neurophysiol. 2018 08; 129(8):1519-1525. PMID: 29804044.
    Citations:    Fields:    
  14. Milekovic T, Sarma AA, Bacher D, Simeral JD, Saab J, Pandarinath C, Sorice BL, Blabe C, Oakley EM, Tringale KR, Eskandar E, Cash SS, Henderson JM, Shenoy KV, Donoghue JP, Hochberg LR. Stable long-term BCI-enabled communication in ALS and locked-in syndrome using LFP signals. J Neurophysiol. 2018 07 01; 120(1):343-360. PMID: 29694279.
    Citations:    Fields:    
  15. Young D, Willett F, Memberg WD, Murphy B, Walter B, Sweet J, Miller J, Hochberg LR, Kirsch RF, Ajiboye AB. Signal processing methods for reducing artifacts in microelectrode brain recordings caused by functional electrical stimulation. J Neural Eng. 2018 04; 15(2):026014. PMID: 29199642.
    Citations:    Fields:    
  16. Brandman DM, Hosman T, Saab J, Burkhart MC, Shanahan BE, Ciancibello JG, Sarma AA, Milstein DJ, Vargas-Irwin CE, Franco B, Kelemen J, Blabe C, Murphy BA, Young DR, Willett FR, Pandarinath C, Stavisky SD, Kirsch RF, Walter BL, Bolu Ajiboye A, Cash SS, Eskandar EN, Miller JP, Sweet JA, Shenoy KV, Henderson JM, Jarosiewicz B, Harrison MT, Simeral JD, Hochberg LR. Rapid calibration of an intracortical brain-computer interface for people with tetraplegia. J Neural Eng. 2018 04; 15(2):026007. PMID: 29363625.
    Citations: 1     Fields:    
  17. Ramirez-Zamora A, Giordano JJ, Gunduz A, Brown P, Sanchez JC, Foote KD, Almeida L, Starr PA, Bronte-Stewart HM, Hu W, McIntyre C, Goodman W, Kumsa D, Grill WM, Walker HC, Johnson MD, Vitek JL, Greene D, Rizzuto DS, Song D, Berger TW, Hampson RE, Deadwyler SA, Hochberg LR, Schiff ND, Stypulkowski P, Worrell G, Tiruvadi V, Mayberg HS, Jimenez-Shahed J, Nanda P, Sheth SA, Gross RE, Lempka SF, Li L, Deeb W, Okun MS. Evolving Applications, Technological Challenges and Future Opportunities in Neuromodulation: Proceedings of the Fifth Annual Deep Brain Stimulation Think Tank. Front Neurosci. 2017; 11:734. PMID: 29416498.
    Citations:    
  18. Willett FR, Murphy BA, Young DR, Memberg WD, Blabe CH, Pandarinath C, Franco B, Saab J, Walter BL, Sweet JA, Miller JP, Henderson JM, Shenoy KV, Simeral JD, Jarosiewicz B, Hochberg LR, Kirsch RF, Ajiboye AB. A Comparison of Intention Estimation Methods for Decoder Calibration in Intracortical Brain-Computer Interfaces. IEEE Trans Biomed Eng. 2018 09; 65(9):2066-2078. PMID: 29989927.
    Citations:    Fields:    
  19. Even-Chen N, Stavisky SD, Pandarinath C, Nuyujukian P, Blabe CH, Hochberg LR, Henderson JM, Shenoy KV. Feasibility of Automatic Error Detect-and-Undo System in Human Intracortical Brain-Computer Interfaces. IEEE Trans Biomed Eng. 2018 08; 65(8):1771-1784. PMID: 29989931.
    Citations: 1     Fields:    
  20. Edlow BL, Chatelle C, Spencer CA, Chu CJ, Bodien YG, O'Connor KL, Hirschberg RE, Hochberg LR, Giacino JT, Rosenthal ES, Wu O. Early detection of consciousness in patients with acute severe traumatic brain injury. Brain. 2017 Sep 01; 140(9):2399-2414. PMID: 29050383.
    Citations: 8     Fields:    Translation:Humans
  21. Ajiboye AB, Willett FR, Young DR, Memberg WD, Murphy BA, Miller JP, Walter BL, Sweet JA, Hoyen HA, Keith MW, Peckham PH, Simeral JD, Donoghue JP, Hochberg LR, Kirsch RF. Restoration of reaching and grasping movements through brain-controlled muscle stimulation in a person with tetraplegia: a proof-of-concept demonstration. Lancet. 2017 05 06; 389(10081):1821-1830. PMID: 28363483.
    Citations: 33     Fields:    Translation:HumansCTClinical Trials
  22. Jarosiewicz B, Sarma AA, Saab J, Franco B, Cash SS, Eskandar EN, Hochberg LR. Retrospectively supervised click decoder calibration for self-calibrating point-and-click brain-computer interfaces. J Physiol Paris. 2016 11; 110(4 Pt A):382-391. PMID: 28286237.
    Citations:    Fields:    Translation:Humans
  23. Brandman DM, Cash SS, Hochberg LR. Review: Human Intracortical Recording and Neural Decoding for Brain-Computer Interfaces. IEEE Trans Neural Syst Rehabil Eng. 2017 10; 25(10):1687-1696. PMID: 28278476.
    Citations: 6     Fields:    Translation:HumansAnimals
  24. Pandarinath C, Nuyujukian P, Blabe CH, Sorice BL, Saab J, Willett FR, Hochberg LR, Shenoy KV, Henderson JM. High performance communication by people with paralysis using an intracortical brain-computer interface. Elife. 2017 02 21; 6. PMID: 28220753.
    Citations: 15     Fields:    Translation:HumansCTClinical Trials
  25. Willett FR, Murphy BA, Memberg WD, Blabe CH, Pandarinath C, Walter BL, Sweet JA, Miller JP, Henderson JM, Shenoy KV, Hochberg LR, Kirsch RF, Ajiboye AB. Signal-independent noise in intracortical brain-computer interfaces causes movement time properties inconsistent with Fitts' law. J Neural Eng. 2017 04; 14(2):026010. PMID: 28177925.
    Citations: 2     Fields:    Translation:Humans
  26. Willett FR, Pandarinath C, Jarosiewicz B, Murphy BA, Memberg WD, Blabe CH, Saab J, Walter BL, Sweet JA, Miller JP, Henderson JM, Shenoy KV, Simeral JD, Hochberg LR, Kirsch RF, Ajiboye AB. Feedback control policies employed by people using intracortical brain-computer interfaces. J Neural Eng. 2017 02; 14(1):016001. PMID: 27900953.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  27. Aghagolzadeh M, Hochberg LR, Cash SS, Truccolo W, Aghagolzadeh M, Hochberg LR, Cash SS, Truccolo W, Cash SS, Truccolo W, Aghagolzadeh M, Hochberg LR. Predicting seizures from local field potentials recorded via intracortical microelectrode arrays. Conf Proc IEEE Eng Med Biol Soc. 2016 Aug; 2016:6353-6356. PMID: 28227963.
    Citations:    
  28. Aghagolzadeh M, Hochberg LR, Cash SS, Truccolo W. Predicting seizures from local field potentials recorded via intracortical microelectrode arrays. Conf Proc IEEE Eng Med Biol Soc. 2016 08; 2016:6353-6356. PMID: 28269702.
    Citations: 3     Fields:    
  29. Bowsher K, Civillico EF, Coburn J, Collinger J, Contreras-Vidal JL, Denison T, Donoghue J, French J, Getzoff N, Hochberg LR, Hoffmann M, Judy J, Kleitman N, Knaack G, Krauthamer V, Ludwig K, Moynahan M, Pancrazio JJ, Peckham PH, Pena C, Pinto V, Ryan T, Saha D, Scharen H, Shermer S, Skodacek K, Takmakov P, Tyler D, Vasudevan S, Wachrathit K, Weber D, Welle CG, Ye M. Brain-computer interface devices for patients with paralysis and amputation: a meeting report. J Neural Eng. 2016 Apr; 13(2):023001. PMID: 26924826.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  30. Jarosiewicz B, Sarma AA, Bacher D, Masse NY, Simeral JD, Sorice B, Oakley EM, Blabe C, Pandarinath C, Gilja V, Cash SS, Eskandar EN, Friehs G, Henderson JM, Shenoy KV, Donoghue JP, Hochberg LR. Virtual typing by people with tetraplegia using a self-calibrating intracortical brain-computer interface. Sci Transl Med. 2015 Nov 11; 7(313):313ra179. PMID: 26560357.
    Citations: 30     Fields:    Translation:Humans
  31. Gilja V, Pandarinath C, Blabe CH, Nuyujukian P, Simeral JD, Sarma AA, Sorice BL, Perge JA, Jarosiewicz B, Hochberg LR, Shenoy KV, Henderson JM. Clinical translation of a high-performance neural prosthesis. Nat Med. 2015 Oct; 21(10):1142-5. PMID: 26413781.
    Citations: 39     Fields:    Translation:Humans
  32. Wagner FB, Eskandar EN, Cosgrove GR, Madsen JR, Blum AS, Potter NS, Hochberg LR, Cash SS, Truccolo W. Microscale spatiotemporal dynamics during neocortical propagation of human focal seizures. Neuroimage. 2015 Nov 15; 122:114-30. PMID: 26279211.
    Citations: 6     Fields:    Translation:HumansCells
  33. Pandarinath C, Gilja V, Blabe CH, Nuyujukian P, Sarma AA, Sorice BL, Eskandar EN, Hochberg LR, Henderson JM, Shenoy KV. Neural population dynamics in human motor cortex during movements in people with ALS. Elife. 2015 Jun 23; 4:e07436. PMID: 26099302.
    Citations: 9     Fields:    Translation:HumansCells
  34. Cash SS, Hochberg LR. The emergence of single neurons in clinical neurology. Neuron. 2015 Apr 08; 86(1):79-91. PMID: 25856488.
    Citations: 9     Fields:    Translation:HumansCells
  35. Masse NY, Jarosiewicz B, Simeral JD, Bacher D, Stavisky SD, Cash SS, Oakley EM, Berhanu E, Eskandar E, Friehs G, Hochberg LR, Donoghue JP. Reprint of "Non-causal spike filtering improves decoding of movement intention for intracortical BCIs". J Neurosci Methods. 2015 Apr 15; 244:94-103. PMID: 25681017.
    Citations: 2     Fields:    
  36. Bacher D, Jarosiewicz B, Masse NY, Stavisky SD, Simeral JD, Newell K, Oakley EM, Cash SS, Friehs G, Hochberg LR. Neural Point-and-Click Communication by a Person With Incomplete Locked-In Syndrome. Neurorehabil Neural Repair. 2015 Jun; 29(5):462-71. PMID: 25385765.
    Citations: 18     Fields:    Translation:Humans
  37. Malik WQ, Hochberg LR, Donoghue JP, Brown EN. Modulation depth estimation and variable selection in state-space models for neural interfaces. IEEE Trans Biomed Eng. 2015 Feb; 62(2):570-81. PMID: 25265627.
    Citations: 4     Fields:    Translation:HumansCells
  38. Masse NY, Jarosiewicz B, Simeral JD, Bacher D, Stavisky SD, Cash SS, Oakley EM, Berhanu E, Eskandar E, Friehs G, Hochberg LR, Donoghue JP. Non-causal spike filtering improves decoding of movement intention for intracortical BCIs. J Neurosci Methods. 2014 Oct 30; 236:58-67. PMID: 25128256.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  39. Truccolo W, Ahmed OJ, Harrison MT, Eskandar EN, Cosgrove GR, Madsen JR, Blum AS, Potter NS, Hochberg LR, Cash SS. Neuronal ensemble synchrony during human focal seizures. J Neurosci. 2014 Jul 23; 34(30):9927-44. PMID: 25057195.
    Citations: 32     Fields:    Translation:HumansCells
  40. Perge JA, Zhang S, Malik WQ, Homer ML, Cash S, Friehs G, Eskandar EN, Donoghue JP, Hochberg LR. Reliability of directional information in unsorted spikes and local field potentials recorded in human motor cortex. J Neural Eng. 2014 Aug; 11(4):046007. PMID: 24921388.
    Citations: 20     Fields:    Translation:Humans
  41. Hochberg LR, Cudkowicz ME. Locked in, but not out? Neurology. 2014 May 27; 82(21):1852-3. PMID: 24789868.
    Citations: 2     Fields:    Translation:Humans
  42. Homer ML, Perge JA, Black MJ, Harrison MT, Cash SS, Hochberg LR. Adaptive offset correction for intracortical brain-computer interfaces. IEEE Trans Neural Syst Rehabil Eng. 2014 Mar; 22(2):239-48. PMID: 24196868.
    Citations: 3     Fields:    Translation:Humans
  43. Park YS, Hochberg LR, Eskandar EN, Cash SS, Truccolo W. Early detection of human focal seizures based on cortical multiunit activity. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:5796-9. PMID: 25571313.
    Citations: 3     Fields:    Translation:Humans
  44. Edlow BL, Giacino JT, Hirschberg RE, Gerrard J, Wu O, Hochberg LR. Unexpected recovery of function after severe traumatic brain injury: the limits of early neuroimaging-based outcome prediction. Neurocrit Care. 2013 Dec; 19(3):364-75. PMID: 23860665.
    Citations: 4     Fields:    Translation:Humans
  45. Henderson JM, Gilja V, Pandarinath C, Blabe C, Hochberg LR, Shenoy KV. 194 High Performance Computer Cursor Control Using Neuronal Ensemble Recordings From the Motor Cortex of a Person With ALS. Neurosurgery. 2013 Aug; 60 Suppl 1:184. PMID: 23839461.
    Citations:    
  46. Jarosiewicz B, Masse NY, Bacher D, Cash SS, Eskandar E, Friehs G, Donoghue JP, Hochberg LR. Advantages of closed-loop calibration in intracortical brain-computer interfaces for people with tetraplegia. J Neural Eng. 2013 Aug; 10(4):046012. PMID: 23838067.
    Citations: 24     Fields:    Translation:Humans
  47. Chan AM, Dykstra AR, Jayaram V, Leonard MK, Travis KE, Gygi B, Baker JM, Eskandar E, Hochberg LR, Halgren E, Cash SS. Speech-specific tuning of neurons in human superior temporal gyrus. Cereb Cortex. 2014 Oct; 24(10):2679-93. PMID: 23680841.
    Citations: 11     Fields:    Translation:HumansCells
  48. Perge JA, Homer ML, Malik WQ, Cash S, Eskandar E, Friehs G, Donoghue JP, Hochberg LR. Intra-day signal instabilities affect decoding performance in an intracortical neural interface system. J Neural Eng. 2013 Jun; 10(3):036004. PMID: 23574741.
    Citations: 42     Fields:    Translation:Humans
  49. Shaikhouni A, Donoghue JP, Hochberg LR. Somatosensory responses in a human motor cortex. J Neurophysiol. 2013 Apr; 109(8):2192-204. PMID: 23343902.
    Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
  50. Homer ML, Nurmikko AV, Donoghue JP, Hochberg LR. Sensors and decoding for intracortical brain computer interfaces. Annu Rev Biomed Eng. 2013; 15:383-405. PMID: 23862678.
    Citations: 18     Fields:    Translation:Humans
  51. Park YS, Hochberg LR, Eskandar EN, Cash SS, Truccolo W. Adaptive Parametric Spectral Estimation with Kalman Smoothing for Online Early Seizure Detection. Int IEEE EMBS Conf Neural Eng. 2013; 1410-1413. PMID: 24663686.
    Citations: 1     
  52. Park YS, Hochberg LR, Eskandar EN, Cash SS, Truccolo W. Early Detection of Human Epileptic Seizures Based on Intracortical Local Field Potentials. Int IEEE EMBS Conf Neural Eng. 2013; 323-326. PMID: 24663490.
    Citations: 1     
  53. Kramer MA, Truccolo W, Eden UT, Lepage KQ, Hochberg LR, Eskandar EN, Madsen JR, Lee JW, Maheshwari A, Halgren E, Chu CJ, Cash SS. Human seizures self-terminate across spatial scales via a critical transition. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):21116-21. PMID: 23213262.
    Citations: 35     Fields:    Translation:Humans
  54. Lewis LD, Weiner VS, Mukamel EA, Donoghue JA, Eskandar EN, Madsen JR, Anderson WS, Hochberg LR, Cash SS, Brown EN, Purdon PL. Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):E3377-86. PMID: 23129622.
    Citations: 101     Fields:    Translation:Humans
  55. Ajiboye AB, Simeral JD, Donoghue JP, Hochberg LR, Kirsch RF. Prediction of imagined single-joint movements in a person with high-level tetraplegia. IEEE Trans Biomed Eng. 2012 Oct; 59(10):2755-65. PMID: 22851229.
    Citations: 10     Fields:    Translation:Humans
  56. Hochberg LR, Bacher D, Jarosiewicz B, Masse NY, Simeral JD, Vogel J, Haddadin S, Liu J, Cash SS, van der Smagt P, Donoghue JP. Reach and grasp by people with tetraplegia using a neurally controlled robotic arm. Nature. 2012 May 16; 485(7398):372-5. PMID: 22596161.
    Citations: 361     Fields:    Translation:Humans
  57. Peyrache A, Dehghani N, Eskandar EN, Madsen JR, Anderson WS, Donoghue JA, Hochberg LR, Halgren E, Cash SS, Destexhe A. Spatiotemporal dynamics of neocortical excitation and inhibition during human sleep. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1731-6. PMID: 22307639.
    Citations: 23     Fields:    Translation:HumansCells
  58. Chadwick EK, Blana D, Simeral JD, Lambrecht J, Kim SP, Cornwell AS, Taylor DM, Hochberg LR, Donoghue JP, Kirsch RF. Continuous neuronal ensemble control of simulated arm reaching by a human with tetraplegia. J Neural Eng. 2011 Jun; 8(3):034003. PMID: 21543840.
    Citations: 31     Fields:    Translation:Humans
  59. Truccolo W, Donoghue JA, Hochberg LR, Eskandar EN, Madsen JR, Anderson WS, Brown EN, Halgren E, Cash SS. Single-neuron dynamics in human focal epilepsy. Nat Neurosci. 2011 May; 14(5):635-41. PMID: 21441925.
    Citations: 120     Fields:    Translation:HumansCells
  60. Simeral JD, Kim SP, Black MJ, Donoghue JP, Hochberg LR. Neural control of cursor trajectory and click by a human with tetraplegia 1000 days after implant of an intracortical microelectrode array. J Neural Eng. 2011 Apr; 8(2):025027. PMID: 21436513.
    Citations: 114     Fields:    Translation:Humans
  61. Kim SP, Simeral JD, Hochberg LR, Donoghue JP, Friehs GM, Black MJ. Point-and-click cursor control with an intracortical neural interface system by humans with tetraplegia. IEEE Trans Neural Syst Rehabil Eng. 2011 Apr; 19(2):193-203. PMID: 21278024.
    Citations: 47     Fields:    Translation:HumansCells
  62. Malik WQ, Truccolo W, Brown EN, Hochberg LR. Efficient decoding with steady-state Kalman filter in neural interface systems. IEEE Trans Neural Syst Rehabil Eng. 2011 Feb; 19(1):25-34. PMID: 21078582.
    Citations: 17     Fields:    Translation:Humans
  63. Keller CJ, Truccolo W, Gale JT, Eskandar E, Thesen T, Carlson C, Devinsky O, Kuzniecky R, Doyle WK, Madsen JR, Schomer DL, Mehta AD, Brown EN, Hochberg LR, Ulbert I, Halgren E, Cash SS. Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex. Brain. 2010 Jun; 133(Pt 6):1668-81. PMID: 20511283.
    Citations: 46     Fields:    Translation:HumansCells
  64. Ajiboye AB, Hochberg LR, Donoghue JP, Kirsch RF. Application of system identification methods for decoding imagined single-joint movements in an individual with high tetraplegia. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:2678-81. PMID: 21096197.
    Citations: 2     Fields:    Translation:HumansCells
  65. Nurmikko AV, Donoghue JP, Hochberg LR, Patterson WR, Song YK, Bull CW, Borton DA, Laiwalla F, Park S, Ming Y, Aceros J. Listening to Brain Microcircuits for Interfacing With External World-Progress in Wireless Implantable Microelectronic Neuroengineering Devices: Experimental systems are described for electrical recording in the brain using multiple microelectrodes and short range implantable or wearable broadcasting units. Proc IEEE Inst Electr Electron Eng. 2010; 98(3):375-388. PMID: 21654935.
    Citations: 19     
  66. Truccolo W, Hochberg LR, Donoghue JP. Collective dynamics in human and monkey sensorimotor cortex: predicting single neuron spikes. Nat Neurosci. 2010 Jan; 13(1):105-11. PMID: 19966837.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  67. Jha RM, Hochberg LR, Hakimelahi R, Hirsch JA, González RG, Yoo AJ. Hyperacute stent placement in acute cervical internal carotid artery occlusions: the potential role of magnetic resonance imaging. J Neurointerv Surg. 2009 Dec; 1(2):171-4. PMID: 21994292.
    Citations:    Fields:    Translation:Humans
  68. Kim SP, Simeral JD, Hochberg LR, Donoghue JP, Black MJ. Neural control of computer cursor velocity by decoding motor cortical spiking activity in humans with tetraplegia. J Neural Eng. 2008 Dec; 5(4):455-76. PMID: 19015583.
    Citations: 104     Fields:    Translation:Humans
  69. Hochberg LR. Turning thought into action. N Engl J Med. 2008 Sep 11; 359(11):1175-7. PMID: 18784110.
    Citations: 5     Fields:    Translation:HumansAnimals
  70. Truccolo W, Friehs GM, Donoghue JP, Hochberg LR. Primary motor cortex tuning to intended movement kinematics in humans with tetraplegia. J Neurosci. 2008 Jan 30; 28(5):1163-78. PMID: 18234894.
    Citations: 66     Fields:    Translation:Humans
  71. Hochberg, L.R., Wolpaw, J.R., Donoghue, J.P., and Ling, G.S.F. Brain-Computer Interfaces: Frontiers in Neurology and Neuroscience (In Press). 2007.
  72. Hochberg LR, Taylor DM. Intuitive prosthetic limb control. Lancet. 2007 Feb 03; 369(9559):345-6. PMID: 17276755.
    Citations: 2     Fields:    Translation:Humans
  73. Donoghue JP, Nurmikko A, Black M, Hochberg LR. Assistive technology and robotic control using motor cortex ensemble-based neural interface systems in humans with tetraplegia. J Physiol. 2007 Mar 15; 579(Pt 3):603-11. PMID: 17272345.
    Citations: 45     Fields:    Translation:Humans
  74. Donoghue JP, Hochberg LR, Nurmikko AV, Black MJ, Simeral JD, Friehs G. Neuromotor prosthesis development. Med Health R I. 2007 Jan; 90(1):12-5. PMID: 17487029.
    Citations: 2     Fields:    Translation:Humans
  75. Hochberg, L.R. Acute Stroke. Decision Making in Medicine: An algorithmic approach. Mushlin S., editor. 2006; (in press).
  76. Kim, S., Simeral, J.D., Donoghue, J.P., Hochberg, L.R., Friehs, G., Mukand, J.A., Chen, D., Black, M.J. A comparison of decoding models for imagined motion from human motor cortex. Society for Neuroscience. 2006.
  77. Shaknarovich, G., Kim, S., Donoghue, J., Hochberg, L.R., Friehs, G.M., Mukand, J.A., Chen, D., Black, M.J. . Modeling neural control of physically realistic movement. Society for Neuroscience. 2006.
  78. Donoghue, J.P., Friehs, G.M., Caplan, A.H., Stein, J., Mukand, J.A., Chen, D., Penn, R.D., Hochberg, L.R. . BrainGate neuromotor prosthesis: First experience by a person with brainstem stroke. Society for Neuroscience. 2006.
  79. Hochberg, L.R., Friehs, G.M., Brown, R.H Jr., Cudkowicz, M.E., Krivickas, L.S., Donoghue, J.P. Voluntary modulation of motor cortical activity by a person with amyotrophic lateral sclerosis: initial BrainGate experience. Society for Neuroscience. 2006.
  80. Hochberg LR, Donoghue JP. Sensors for brain-computer interfaces. IEEE Eng Med Biol Mag. 2006 Sep-Oct; 25(5):32-8. PMID: 17020197.
    Citations: 15     Fields:    Translation:Humans
  81. Friehs G, Penn RD, Park MC, Goldman M, Zerris VA, Hochberg LR, Chen D, Mukand J, Donoghue JD. Initial Surgical Experience with an Intracortical Microelectrode Array for Brain-computer Interface Applications 881. Neurosurgery. 2006 Aug 01; 59(2):481. PMID: 28180721.
    Citations:    
  82. Hochberg LR, Serruya MD, Friehs GM, Mukand JA, Saleh M, Caplan AH, Branner A, Chen D, Penn RD, Donoghue JP. Neuronal ensemble control of prosthetic devices by a human with tetraplegia. Nature. 2006 Jul 13; 442(7099):164-71. PMID: 16838014.
    Citations: 583     Fields:    Translation:Humans
  83. Kübler A, Mushahwar VK, Hochberg LR, Donoghue JP. BCI Meeting 2005--workshop on clinical issues and applications. IEEE Trans Neural Syst Rehabil Eng. 2006 Jun; 14(2):131-4. PMID: 16792277.
    Citations: 17     Fields:    Translation:Humans
  84. Aaron RK, Herr HM, Ciombor DM, Hochberg LR, Donoghue JP, Briant CL, Morgan JR, Ehrlich MG. Horizons in prosthesis development for the restoration of limb function. J Am Acad Orthop Surg. 2006; 14(10 Spec No.):S198-204. PMID: 17003199.
    Citations: 6     Fields:    Translation:Humans
  85. Friehs, G.M., Penn, R.D., Park, M.C., Goldman, M., Zedrris, V.A., Hochberg, L.R., Chen, D., Mukand, J., Donoghue, J.P. Initial Surgical Experience with an Intracortical Microelectrode Array for Brain-Computer Interface Applications. Congress of Neurological Surgeons. 2006.
  86. Hochberg, L.R., Serruya, M.D., Mukand, J.A., Friehs, G.M., and Donoghue, J.P. . Intracortical recordings for Brain-Computer Interfaces and Acute Neuronal Ensemble Monitoring. American Academy of Neurology Annual Meeting. 2006.
  87. Zerris VA, Donoghue JD, Hochberg LR, O'Rourke DK, Chiocca EA. 885 Braingate: Turning Thought into Action-First Experience with a Human Neuromotor Prosthesis. Neurosurgery. 2005 Aug 01; 57(2):425. PMID: 28184816.
    Citations:    
  88. Furie, K.L. and Hochberg, L.R. A 50 year-old right-handed man presents with left face and arm weakness. 2005.
  89. Zerris, V.A., Donoghue, J.P., Hochberg, L.R., and Friehs, G. . BrainGate: Turning Thought into Action: First experience with a human neuro-motor prosthesis. Congress of Neurological Surgeons. 2005.
  90. Furie, K.L. and Hochberg, L.R. Secondary stroke prevention in a woman with atrial fibrillation and stroke with hemorrhagic conversion. 2005.
  91. Hochberg, L.R., Mukand, J.A., Friehs, G.M., and Donoghue, J.P. . BrainGate Neural Interface System: Feasibility Study of a Human Neuromotor Prosthesis. American Academy of Neurology Annual Meeting. 2005; P06.054.
  92. Hochberg, L.R., Mukand, J.A., Polykoff, G.M. Friehs, G.M., and Donoghue, J.P. . BrainGate Neuromotor Prosthesis: Nature and use of neural control signals. Society for Neuroscience. 2005.
  93. Hochberg, L.R., and Schwamm, L.H. Stroke, Seizure, and Encephalopathy. Critical Care Handbook of the Massachusetts General Hospital. 2005.
  94. Hochberg, L.R., Mukand, J.A., Williams, S., Polykoff, G., Friehs, G.M., and Donoghue, J.P. Brain-Computer Interfaces: Prospects for Neuro-Rehabilitation and Implications for Neurocritical Care. Neurocritical Care Society Annual Meeting. 2005.
  95. Hochberg, L.R., Mukand, J.A., Friehs, G.M., and Donoghue, J.P. BrainGate: Feasibility of a Human Neuromotor Prosthesis for Persons with Tetraplegia. Christopher Reeve Paralysis Foundation. 2005.
  96. Hochberg, L.R., Suner, S., Fellows, M.R., Friehs, G.M., and Donoghue, J.P. . Intracortical recordings from a 96-microelectrode array: Potential applications in Human Neurophysiology. 59th Annual Meeting of the American Epilepsy Society and the American Clinical Neurophysiology Society. 2005.
  97. Park, M., Zerris, V., Hochberg, L.R., Donoghue, J.P., Mukand, J.A., and Friehs, G.M. BrainGate – First experience with an implantable human neuro-motor prosthesis. North American Neuromodulation Society. 2005.
  98. Buonanno, F.S. and Hochberg, L.R. Secondary stroke prevention in a young woman with patent foramen ovale. 2004.
  99. Feske, S.K. and Hochberg, L.R. A 65-year-old man presents to the emergency room complaining of arm weakness and inability to speak. 2004.
  100. Schwamm, L.H., Hochberg, L.R., Petkovska, I., Sokal, S., Furie, K.L., Hylek, E.M., Little, E.A., Gleason, S. Web-enabled decision support improves anticoagulation management in hospitalized patients with stroke/TIA. 28th International Stroke Conference. 2003.
  101. Dickerson, B.C., Hochberg, L.R., Bordelon, Y.M., Kesari, S., Lester, J.E., Feske, S.K., Charness, M.E., Koroshetz, W.J., Samuels, M.A., and Young, A.B. . You can be in two places at once: A technology-driven method for delivering a uniform curriculum to neurology residents in geographically distributed programs. American Academy of Neurology Annual Meeting. 2003.
  102. Hochberg LR, Sims JR, Davis BT. West Nile encephalitis in Massachusetts. N Engl J Med. 2002 Mar 28; 346(13):1030-1. PMID: 11919319.
    Citations:    Fields:    Translation:HumansPHPublic Health
  103. Hochberg, L.R. Primary motor cortex: Functional reorganization with acquisition of subtly changing motor tasks, and suitability of multi-site, multi-unit recordings for control of a prosthetic device [Ph.D. dissertation]. 1998.
  104. Humphrey, D.R., Hochberg, L.R., and Reed, D.J. Cortical excitability decreases and MI forelimb muscle maps fractionate with acquisition of a more precise motor task. Soc. Neuro. Abs. 1997; (607.14).
  105. Reed, D.J., Hochberg, L.R., Burrow, M.F., Dugger, J., and Humphrey, D.R. Real-time, off-line control of a robot wrist from macaque MI recordings. Soc. Neuro. Abs. 1997; (607.13).
  106. Burrow, M., Dugger, J., Humphrey, D.R., Reed, D.J., and Hochberg, L.R. Cortical control of a robot using a time-delay neural network. Proceedings of the Fifth International Conference on Rehabilitation Robotics. 1997.
  107. Hochberg, L.R., Reed, D.J., and Humphrey, D.R. MI forelimb muscle maps change with acquisition of a task which reverses a learned visuomotor relationship. Soc. Neuro. Abs. 1997; (607.15).
  108. Hochberg, L.R., and Kogelnik, A.M. Integrated e-mail, conferencing, and document management for medical education at Emory University. Association of American Medical Colleges. 1996.
  109. Humphrey, D.R., and Hochberg, L.R. Intracortical recording of brain activity for control of limb prostheses. Proceedings of the Rehabilitation Engineering Society of North America. 1995; 650-658.
  110. Humphrey, D.R., Reed, D.J., Mewes, K., Hochberg, L.R., and Burrow, M. Update on new techniques for processing multichannel neural/EMG recordings. Soc. Neuro. Abs. 1993; (319.10).
  111. Friedberg, M.H., Lee, S.M., Hochberg, L.R., and Ebner, F.F. Lesion of the supragranular layers of barrel field cortex impairs the acquisition but not the performance of a cortically dependent behavioral task. Soc. Neuro. Abs. 1990; (25.18).
  112. Hochberg, L.R. Behavioral effects of supragranular lesions in the rat posteromedial barrel subfield [undergraduate thesis]. 1990.
  113. Crystal, H.A., Hochberg, L.R., Grober, E., Scarisbrick, D., and Buschke, H. . Circadian rhythm in cognitive performance in dementia. Neurology. 1989; 39(sup. 1, 3).
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