Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Patricia A. D'Amore, Ph.D.

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Other Positions
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Institution
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Mentoring
current student opportunities
Available: 09/01/18, Expires: 09/30/21

The projects uses cell biological, biochemical and molecular techniques as well as animal models to understand the steps leading to the development of age-related macular degeneration. The focus is on the role of lipids andinflammation.

completed student projects
Changes in Cerebral Blood Flow following Traumatic Brain Injury
Soma Weiss, 08/01/19 - 06/30/20
Troglitazone Prevents Oxidized LDL-induced RPE Dysfunction by Suppressing Inflammatory Pathways
Full Time/Year Long, 06/01/16 - 08/31/16

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R13EY031989 (D'AMORE, PATRICIA ANN) Sep 30, 2020 - Sep 29, 2021
    NIH
    The Sixth Biennial International Symposium on Age-related Macular Degeneration
    Role: Principal Investigator
  2. R13EY029583 (D'AMORE, PATRICIA ANN) Aug 5, 2018 - Jul 31, 2019
    NIH
    Fifth International Biennial Symposium on Age-related Macular Degeneration (AMD)
    Role: Principal Investigator
  3. R01EY026539 (D'AMORE, PATRICIA ANN) Feb 1, 2017 - Jul 31, 2025
    NIH
    Investigation of endomucin as a novel regulator of angiogenesis
    Role: Principal Investigator
  4. R13EY027181 (D'AMORE, PATRICIA ANN) Aug 1, 2016 - Jul 31, 2017
    NIH
    Fourth Biennial AMD Symposium
    Role: Principal Investigator
  5. R13EY024813 (D'AMORE, PATRICIA ANN) Aug 1, 2014 - Jul 31, 2015
    NIH
    Third Biennial Symposium on Age Related Macular Degeneration
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gnanaguru G, Wagschal A, Oh J, Saez-Torres KL, Li T, Temel RE, Kleinman ME, Näär AM, D'Amore PA. Targeting of miR-33 ameliorates phenotypes linked to age-related macular degeneration. Mol Ther. 2021 07 07; 29(7):2281-2293. PMID: 33744470.
    Citations:    Fields:    
  2. Uemura A, Fruttiger M, D'Amore PA, De Falco S, Joussen AM, Sennlaub F, Brunck LR, Johnson KT, Lambrou GN, Rittenhouse KD, Langmann T. VEGFR1 signaling in retinal angiogenesis and microinflammation. Prog Retin Eye Res. 2021 Feb 25; 100954. PMID: 33640465.
    Citations: 1     Fields:    
  3. Hu Z, Cano I, Saez-Torres KL, LeBlanc ME, Saint-Geniez M, Ng YS, Argüeso P, D'Amore PA. Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity. Cells. 2020 06 05; 9(6). PMID: 32517158.
    Citations: 1     Fields:    Translation:HumansCells
  4. Yang J, LeBlanc ME, Cano I, Saez-Torres KL, Saint-Geniez M, Ng YS, D'Amore PA. ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface. J Biol Chem. 2020 05 08; 295(19):6641-6651. PMID: 32193206.
    Citations: 5     Fields:    Translation:HumansCells
  5. LeBlanc ME, Saez-Torres KL, Cano I, Hu Z, Saint-Geniez M, Ng YS, D'Amore PA. Glycocalyx regulation of vascular endothelial growth factor receptor 2 activity. FASEB J. 2019 08; 33(8):9362-9373. PMID: 31141406.
    Citations: 8     Fields:    Translation:HumansCells
  6. Park-Windhol C, Ng YS, Yang J, Primo V, Saint-Geniez M, D'Amore PA. Endomucin inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling. Sci Rep. 2017 12 07; 7(1):17138. PMID: 29215001.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  7. Wu W, Duan Y, Ma G, Zhou G, Park-Windhol C, D'Amore PA, Lei H. AAV-CRISPR/Cas9-Mediated Depletion of VEGFR2 Blocks Angiogenesis In Vitro. Invest Ophthalmol Vis Sci. 2017 12 01; 58(14):6082-6090. PMID: 29204648.
    Citations: 8     Fields:    Translation:HumansCells
  8. Zhou G, Duan Y, Ma G, Wu W, Hu Z, Chen N, Chee Y, Cui J, Samad A, Matsubara JA, Mukai S, D'Amore PA, Lei H. Introduction of the MDM2 T309G Mutation in Primary Human Retinal Epithelial Cells Enhances Experimental Proliferative Vitreoretinopathy. Invest Ophthalmol Vis Sci. 2017 10 01; 58(12):5361-5367. PMID: 29049737.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  9. Huang X, Zhou G, Wu W, Duan Y, Ma G, Song J, Xiao R, Vandenberghe L, Zhang F, D'Amore PA, Lei H. Genome editing abrogates angiogenesis in vivo. Nat Commun. 2017 07 24; 8(1):112. PMID: 28740073.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  10. Machuca-Parra AI, Bigger-Allen AA, Sanchez AV, Boutabla A, Cardona-Vélez J, Amarnani D, Saint-Geniez M, Siebel CW, Kim LA, D'Amore PA, Arboleda-Velasquez JF. Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL. J Exp Med. 2017 Aug 07; 214(8):2271-2282. PMID: 28698285.
    Citations: 13     Fields:    Translation:AnimalsCells
  11. Wu W, Tang L, D'Amore PA, Lei H. Application of CRISPR-Cas9 in eye disease. Exp Eye Res. 2017 08; 161:116-123. PMID: 28619505.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  12. Lam JD, Oh DJ, Wong LL, Amarnani D, Park-Windhol C, Sanchez AV, Cardona-Velez J, McGuone D, Stemmer-Rachamimov AO, Eliott D, Bielenberg DR, van Zyl T, Shen L, Gai X, D'Amore PA, Kim LA, Arboleda-Velasquez JF. Identification of RUNX1 as a Mediator of Aberrant Retinal Angiogenesis. Diabetes. 2017 07; 66(7):1950-1956. PMID: 28400392.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  13. Huang X, Zhou G, Wu W, Ma G, D'Amore PA, Mukai S, Lei H. Editing VEGFR2 Blocks VEGF-Induced Activation of Akt and Tube Formation. Invest Ophthalmol Vis Sci. 2017 02 01; 58(2):1228-1236. PMID: 28241310.
    Citations: 13     Fields:    Translation:HumansCells
  14. Gnanaguru G, Choi AR, Amarnani D, D'Amore PA. Oxidized Lipoprotein Uptake Through the CD36 Receptor Activates the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells. Invest Ophthalmol Vis Sci. 2016 09 01; 57(11):4704-12. PMID: 27607416.
    Citations: 21     Fields:    Translation:HumansCells
  15. Wong LL, Lee NG, Amarnani D, Choi CJ, Bielenberg DR, Freitag SK, D'Amore PA, Kim LA. Orbital Angiogenesis and Lymphangiogenesis in Thyroid Eye Disease: An Analysis of Vascular Growth Factors with Clinical Correlation. Ophthalmology. 2016 09; 123(9):2028-36. PMID: 27423310.
    Citations: 7     Fields:    Translation:Humans
  16. Ma G, Duan Y, Huang X, Qian CX, Chee Y, Mukai S, Cui J, Samad A, Matsubara JA, Kazlauskas A, D'Amore PA, Gu S, Lei H. Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases. Invest Ophthalmol Vis Sci. 2016 07 01; 57(8):3935-43. PMID: 27472081.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  17. Duan Y, Ma G, Huang X, D'Amore PA, Zhang F, Lei H. The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-created MDM2 T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and Survival of Cells. J Biol Chem. 2016 07 29; 291(31):16339-47. PMID: 27246850.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  18. Kim CB, D'Amore PA, Connor KM. Revisiting the mouse model of oxygen-induced retinopathy. Eye Brain. 2016; 8:67-79. PMID: 27499653.
    Citations: 29     
  19. Primo V, Graham M, Bigger-Allen AA, Chick JM, Ospina C, Quiroz YT, Manent J, Gygi SP, Lopera F, D'Amore PA, Arboleda-Velasquez JF. Blood biomarkers in a mouse model of CADASIL. Brain Res. 2016 08 01; 1644:118-26. PMID: 27174004.
    Citations: 6     Fields:    Translation:HumansAnimals
  20. Park-Windhol C, D'Amore PA. Disorders of Vascular Permeability. Annu Rev Pathol. 2016 05 23; 11:251-81. PMID: 26907525.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  21. Shahrabi-Farahani S, Gallottini M, Martins F, Li E, Mudge DR, Nakayama H, Hida K, Panigrahy D, D'Amore PA, Bielenberg DR. Neuropilin 1 Receptor Is Up-Regulated in Dysplastic Epithelium and Oral Squamous Cell Carcinoma. Am J Pathol. 2016 Apr; 186(4):1055-64. PMID: 26877262.
    Citations: 4     Fields:    Translation:HumansCells
  22. Zahr A, Alcaide P, Yang J, Jones A, Gregory M, dela Paz NG, Patel-Hett S, Nevers T, Koirala A, Luscinskas FW, Saint-Geniez M, Ksander B, D'Amore PA, Argüeso P. Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions. Nat Commun. 2016 Feb 02; 7:10363. PMID: 26831939.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  23. Sánchez-Palencia DM, Bigger-Allen A, Saint-Geniez M, Arboleda-Velásquez JF, D'Amore PA. Coculture Assays for Endothelial Cells-Mural Cells Interactions. Methods Mol Biol. 2016; 1464:35-47. PMID: 27858354.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  24. Kim LA, Wong LL, Amarnani DS, Bigger-Allen AA, Hu Y, Marko CK, Eliott D, Shah VA, McGuone D, Stemmer-Rachamimov AO, Gai X, D'Amore PA, Arboleda-Velasquez JF. Characterization of cells from patient-derived fibrovascular membranes in proliferative diabetic retinopathy. Mol Vis. 2015; 21:673-87. PMID: 26120272.
    Citations: 4     Fields:    Translation:HumansCells
  25. Arboleda-Velasquez JF, Valdez CN, Marko CK, D'Amore PA. From pathobiology to the targeting of pericytes for the treatment of diabetic retinopathy. Curr Diab Rep. 2015 Feb; 15(2):573. PMID: 25620405.
    Citations: 14     Fields:    Translation:HumansCells
  26. Bielenberg DR, D'Amore PA. Lymphatics in development and pathology: introduction to a special issue of Microvascular Research. Microvasc Res. 2014 Nov; 96:1-2. PMID: 25200924.
    Citations:    Fields:    Translation:HumansAnimals
  27. Valdez CN, Arboleda-Velasquez JF, Amarnani DS, Kim LA, D'Amore PA. Retinal microangiopathy in a mouse model of inducible mural cell loss. Am J Pathol. 2014 Oct; 184(10):2618-26. PMID: 25092275.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  28. Panigrahy D, Adini I, Mamluk R, Levonyak N, Bruns CJ, D'Amore PA, Klagsbrun M, Bielenberg DR. Regulation of soluble neuropilin 1, an endogenous angiogenesis inhibitor, in liver development and regeneration. Pathology. 2014 Aug; 46(5):416-23. PMID: 24977735.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  29. Arboleda-Velasquez JF, Primo V, Graham M, James A, Manent J, D'Amore PA. Notch signaling functions in retinal pericyte survival. Invest Ophthalmol Vis Sci. 2014 Jul 11; 55(8):5191-9. PMID: 25015359.
    Citations: 13     Fields:    Translation:AnimalsCells
  30. Kim LA, Amarnani D, Gnanaguru G, Tseng WA, Vavvas DG, D'Amore PA. Tamoxifen toxicity in cultured retinal pigment epithelial cells is mediated by concurrent regulated cell death mechanisms. Invest Ophthalmol Vis Sci. 2014 Jul 03; 55(8):4747-58. PMID: 24994868.
    Citations: 17     Fields:    Translation:HumansCells
  31. Shahrabi-Farahani S, Wang L, Zwaans BM, Santana JM, Shimizu A, Takashima S, Kreuter M, Coultas L, D'Amore PA, Arbeit JM, Akslen LA, Bielenberg DR. Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas. Lab Invest. 2014 Jul; 94(7):752-65. PMID: 24791743.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  32. Walshe TE, dela Paz NG, D'Amore PA. The role of shear-induced transforming growth factor-ß signaling in the endothelium. Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11):2608-17. PMID: 23968981.
    Citations: 25     Fields:    Translation:HumansCells
  33. Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW. Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13528-33. PMID: 23898174.
    Citations: 60     Fields:    Translation:AnimalsCells
  34. Bagchi M, Kim LA, Boucher J, Walshe TE, Kahn CR, D'Amore PA. Vascular endothelial growth factor is important for brown adipose tissue development and maintenance. FASEB J. 2013 Aug; 27(8):3257-71. PMID: 23682123.
    Citations: 33     Fields:    Translation:AnimalsCells
  35. Bielenberg DR, D'Amore PA. All vessels are not created equal. Am J Pathol. 2013 Apr; 182(4):1087-91. PMID: 23422091.
    Citations: 1     Fields:    Translation:HumansAnimals
  36. Tseng WA, Thein T, Kinnunen K, Lashkari K, Gregory MS, D'Amore PA, Ksander BR. NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci. 2013 Jan 07; 54(1):110-20. PMID: 23221073.
    Citations: 116     Fields:    Translation:HumansCells
  37. Jia D, Hasso SM, Chan J, Filingeri D, D'Amore PA, Rice L, Pampo C, Siemann DW, Zurakowski D, Rodig SJ, Moses MA. Transcriptional repression of VEGF by ZNF24: mechanistic studies and vascular consequences in vivo. Blood. 2013 Jan 24; 121(4):707-15. PMID: 23212515.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  38. Ford KM, Saint-Geniez M, Walshe TE, D'Amore PA. Expression and role of VEGF--a in the ciliary body. Invest Ophthalmol Vis Sci. 2012 Nov 07; 53(12):7520-7. PMID: 23081980.
    Citations: 11     Fields:    Translation:Animals
  39. Kim LA, D'Amore PA. A brief history of anti-VEGF for the treatment of ocular angiogenesis. Am J Pathol. 2012 Aug; 181(2):376-9. PMID: 22749677.
    Citations: 40     Fields:    Translation:HumansAnimals
  40. Maruyama K, Nakazawa T, Cursiefen C, Maruyama Y, Van Rooijen N, D'Amore PA, Kinoshita S. The maintenance of lymphatic vessels in the cornea is dependent on the presence of macrophages. Invest Ophthalmol Vis Sci. 2012 May 31; 53(6):3145-53. PMID: 22511631.
    Citations: 22     Fields:    Translation:AnimalsCells
  41. Ford KM, D'Amore PA. Molecular regulation of vascular endothelial growth factor expression in the retinal pigment epithelium. Mol Vis. 2012; 18:519-27. PMID: 22419845.
    Citations: 13     Fields:    Translation:HumansCells
  42. dela Paz NG, Walshe TE, Leach LL, Saint-Geniez M, D'Amore PA. Role of shear-stress-induced VEGF expression in endothelial cell survival. J Cell Sci. 2012 Feb 15; 125(Pt 4):831-43. PMID: 22399811.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  43. Cao Y, Arbiser J, D'Amato RJ, D'Amore PA, Ingber DE, Kerbel R, Klagsbrun M, Lim S, Moses MA, Zetter B, Dvorak H, Langer R. Forty-year journey of angiogenesis translational research. Sci Transl Med. 2011 Dec 21; 3(114):114rv3. PMID: 22190240.
    Citations: 76     Fields:    Translation:Humans
  44. Panigrahy D, Edin ML, Lee CR, Huang S, Bielenberg DR, Butterfield CE, Barnés CM, Mammoto A, Mammoto T, Luria A, Benny O, Chaponis DM, Dudley AC, Greene ER, Vergilio JA, Pietramaggiori G, Scherer-Pietramaggiori SS, Short SM, Seth M, Lih FB, Tomer KB, Yang J, Schwendener RA, Hammock BD, Falck JR, Manthati VL, Ingber DE, Kaipainen A, D'Amore PA, Kieran MW, Zeldin DC. Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest. 2012 Jan; 122(1):178-91. PMID: 22182838.
    Citations: 118     Fields:    Translation:HumansAnimals
  45. Ford KM, Saint-Geniez M, Walshe T, Zahr A, D'Amore PA. Expression and role of VEGF in the adult retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2011 Dec 09; 52(13):9478-87. PMID: 22058334.
    Citations: 59     Fields:    Translation:AnimalsCells
  46. Sekiyama E, Saint-Geniez M, Yoneda K, Hisatomi T, Nakao S, Walshe TE, Maruyama K, Hafezi-Moghadam A, Miller JW, Kinoshita S, D'Amore PA. Heat treatment of retinal pigment epithelium induces production of elastic lamina components and antiangiogenic activity. FASEB J. 2012 Feb; 26(2):567-75. PMID: 22067481.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  47. Darland DC, Cain JT, Berosik MA, Saint-Geniez M, Odens PW, Schaubhut GJ, Frisch S, Stemmer-Rachamimov A, Darland T, D'Amore PA. Vascular endothelial growth factor (VEGF) isoform regulation of early forebrain development. Dev Biol. 2011 Oct 01; 358(1):9-22. PMID: 21803034.
    Citations: 15     Fields:    Translation:Animals
  48. Walshe TE, Leach LL, D'Amore PA. TGF-ß signaling is required for maintenance of retinal ganglion cell differentiation and survival. Neuroscience. 2011 Aug 25; 189:123-31. PMID: 21664439.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  49. Wang H, Geisen P, Wittchen ES, King B, Burridge K, D'Amore PA, Hartnett ME. The role of RPE cell-associated VEGF189 in choroidal endothelial cell transmigration across the RPE. Invest Ophthalmol Vis Sci. 2011 Jan; 52(1):570-8. PMID: 20811045.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  50. Patel-Hett S, D'Amore PA. Signal transduction in vasculogenesis and developmental angiogenesis. Int J Dev Biol. 2011; 55(4-5):353-63. PMID: 21732275.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  51. Lee YJ, Karl DL, Maduekwe UN, Rothrock C, Ryeom S, D'Amore PA, Yoon SS. Differential effects of VEGFR-1 and VEGFR-2 inhibition on tumor metastases based on host organ environment. Cancer Res. 2010 Nov 01; 70(21):8357-67. PMID: 20978198.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  52. Bryan BA, Dennstedt E, Mitchell DC, Walshe TE, Noma K, Loureiro R, Saint-Geniez M, Campaigniac JP, Liao JK, D'Amore PA. RhoA/ROCK signaling is essential for multiple aspects of VEGF-mediated angiogenesis. FASEB J. 2010 Sep; 24(9):3186-95. PMID: 20400538.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  53. D'Amore PA. Editorial. Microvasc Res. 2010 May; 79(3):161. PMID: 20171233.
    Citations:    Fields:    Translation:HumansAnimalsCells
  54. Fukumoto A, Maruyama K, Walsh T, Kajiya K, Hamuro J, D'Amore PA, Kinoshita S. Intracellular thiol redox status regulates lymphangiogenesis and dictates corneal limbal graft survival. Invest Ophthalmol Vis Sci. 2010 May; 51(5):2450-8. PMID: 20042658.
    Citations: 1     Fields:    Translation:AnimalsCells
  55. Saint-Geniez M, Kurihara T, Sekiyama E, Maldonado AE, D'Amore PA. An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18751-6. PMID: 19841260.
    Citations: 181     Fields:    Translation:AnimalsCells
  56. Nieves BJ, D'Amore PA, Bryan BA. The function of vascular endothelial growth factor. Biofactors. 2009 Jul-Aug; 35(4):332-7. PMID: 19415738.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  57. Walshe TE, Dole VS, Maharaj AS, Patten IS, Wagner DD, D'Amore PA. Inhibition of VEGF or TGF-{beta} signaling activates endothelium and increases leukocyte rolling. Arterioscler Thromb Vasc Biol. 2009 Aug; 29(8):1185-92. PMID: 19461051.
    Citations: 27     Fields:    Translation:AnimalsCells
  58. Walshe TE, Saint-Geniez M, Maharaj AS, Sekiyama E, Maldonado AE, D'Amore PA. TGF-beta is required for vascular barrier function, endothelial survival and homeostasis of the adult microvasculature. PLoS One. 2009; 4(4):e5149. PMID: 19340291.
    Citations: 78     Fields:    Translation:AnimalsCells
  59. D'Amore P, D'Amato R. Seminars in Ophthalmology. Editorial. Semin Ophthalmol. 2009 Mar-Apr; 24(2):50-1. PMID: 19373686.
    Citations:    Fields:    Translation:HumansAnimals
  60. Saint-Geniez M, Maharaj AS, Walshe TE, Tucker BA, Sekiyama E, Kurihara T, Darland DC, Young MJ, D'Amore PA. Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors. PLoS One. 2008; 3(11):e3554. PMID: 18978936.
    Citations: 245     Fields:    Translation:AnimalsCells
  61. dela Paz NG, D'Amore PA. Arterial versus venous endothelial cells. Cell Tissue Res. 2009 Jan; 335(1):5-16. PMID: 18972135.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  62. Saint-Geniez M, Kurihara T, D'Amore PA. Role of cell and matrix-bound VEGF isoforms in lens development. Invest Ophthalmol Vis Sci. 2009 Jan; 50(1):311-21. PMID: 18757513.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  63. Sang DN, D'Amore PA. Is blockade of vascular endothelial growth factor beneficial for all types of diabetic retinopathy? Diabetologia. 2008 Sep; 51(9):1570-3. PMID: 18607560.
    Citations: 13     Fields:    Translation:Humans
  64. Chao W, D'Amore PA. IGF2: epigenetic regulation and role in development and disease. Cytokine Growth Factor Rev. 2008 Apr; 19(2):111-20. PMID: 18308616.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  65. Fernando NT, Koch M, Rothrock C, Gollogly LK, D'Amore PA, Ryeom S, Yoon SS. Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors. Clin Cancer Res. 2008 Mar 01; 14(5):1529-39. PMID: 18316578.
    Citations: 69     Fields:    Translation:AnimalsCells
  66. Maharaj AS, Walshe TE, Saint-Geniez M, Venkatesha S, Maldonado AE, Himes NC, Matharu KS, Karumanchi SA, D'Amore PA. VEGF and TGF-beta are required for the maintenance of the choroid plexus and ependyma. J Exp Med. 2008 Feb 18; 205(2):491-501. PMID: 18268040.
    Citations: 55     Fields:    Translation:AnimalsCells
  67. Bryan BA, D'Amore PA. Pericyte isolation and use in endothelial/pericyte coculture models. Methods Enzymol. 2008; 443:315-31. PMID: 18772023.
    Citations: 27     Fields:    Translation:AnimalsCells
  68. Walshe TE, D'Amore PA. The role of hypoxia in vascular injury and repair. Annu Rev Pathol. 2008; 3:615-43. PMID: 18039132.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  69. Bielenberg DR, D'Amore PA. Judah Folkman's contribution to the inhibition of angiogenesis. Lymphat Res Biol. 2008; 6(3-4):203-7. PMID: 19093793.
    Citations: 2     Fields:    Translation:HumansAnimals
  70. Bryan BA, Walshe TE, Mitchell DC, Havumaki JS, Saint-Geniez M, Maharaj AS, Maldonado AE, D'Amore PA. Coordinated vascular endothelial growth factor expression and signaling during skeletal myogenic differentiation. Mol Biol Cell. 2008 Mar; 19(3):994-1006. PMID: 18094043.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  71. Harper J, Yan L, Loureiro RM, Wu I, Fang J, D'Amore PA, Moses MA. Repression of vascular endothelial growth factor expression by the zinc finger transcription factor ZNF24. Cancer Res. 2007 Sep 15; 67(18):8736-41. PMID: 17875714.
    Citations: 22     Fields:    Translation:HumansCells
  72. Bryan BA, D'Amore PA. What tangled webs they weave: Rho-GTPase control of angiogenesis. Cell Mol Life Sci. 2007 Aug; 64(16):2053-65. PMID: 17530172.
    Citations: 62     Fields:    Translation:AnimalsCells
  73. D'Amore PA. Vascular endothelial cell growth factor-a: not just for endothelial cells anymore. Am J Pathol. 2007 Jul; 171(1):14-8. PMID: 17591949.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  74. Ramsauer M, D'Amore PA. Contextual role for angiopoietins and TGFbeta1 in blood vessel stabilization. J Cell Sci. 2007 May 15; 120(Pt 10):1810-7. PMID: 17502485.
    Citations: 21     Fields:    Translation:AnimalsCells
  75. Maharaj AS, D'Amore PA. Roles for VEGF in the adult. Microvasc Res. 2007 Sep-Nov; 74(2-3):100-13. PMID: 17532010.
    Citations: 66     Fields:    Translation:Humans
  76. Maruyama K, Asai J, Ii M, Thorne T, Losordo DW, D'Amore PA. Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am J Pathol. 2007 Apr; 170(4):1178-91. PMID: 17392158.
    Citations: 137     Fields:    Translation:AnimalsCells
  77. Goodwin AM, Kitajewski J, D'Amore PA. Wnt1 and Wnt5a affect endothelial proliferation and capillary length; Wnt2 does not. Growth Factors. 2007 Feb; 25(1):25-32. PMID: 17454147.
    Citations: 31     Fields:    Translation:AnimalsCells
  78. Banerjee S, Sengupta K, Dhar K, Mehta S, D'Amore PA, Dhar G, Banerjee SK. Breast cancer cells secreted platelet-derived growth factor-induced motility of vascular smooth muscle cells is mediated through neuropilin-1. Mol Carcinog. 2006 Nov; 45(11):871-80. PMID: 16847823.
    Citations: 37     Fields:    Translation:HumansCells
  79. Goodwin AM, Sullivan KM, D'Amore PA. Cultured endothelial cells display endogenous activation of the canonical Wnt signaling pathway and express multiple ligands, receptors, and secreted modulators of Wnt signaling. Dev Dyn. 2006 Nov; 235(11):3110-20. PMID: 17013885.
    Citations: 54     Fields:    Translation:HumansCells
  80. Saint-Geniez M, Maldonado AE, D'Amore PA. VEGF expression and receptor activation in the choroid during development and in the adult. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):3135-42. PMID: 16799060.
    Citations: 80     Fields:    Translation:AnimalsCells
  81. Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, Bdolah Y, Lim KH, Yuan HT, Libermann TA, Stillman IE, Roberts D, D'Amore PA, Epstein FH, Sellke FW, Romero R, Sukhatme VP, Letarte M, Karumanchi SA. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med. 2006 Jun; 12(6):642-9. PMID: 16751767.
    Citations: 510     Fields:    Translation:HumansAnimalsCells
  82. Lutty GA, Chan-Ling T, Phelps DL, Adamis AP, Berns KI, Chan CK, Cole CH, D'Amore PA, Das A, Deng WT, Dobson V, Flynn JT, Friedlander M, Fulton A, Good WV, Grant MB, Hansen R, Hauswirth WW, Hardy RJ, Hinton DR, Hughes S, McLeod DS, Palmer EA, Patz A, Penn JS, Raisler BJ, Repka MX, Saint-Geniez M, Shaw LC, Shima DT, Smith BT, Smith LE, Tahija SG, Tasman W, Trese MT. Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis. 2006 May 23; 12:532-80. PMID: 16735995.
    Citations: 23     Fields:    Translation:Humans
  83. Maharaj AS, Saint-Geniez M, Maldonado AE, D'Amore PA. Vascular endothelial growth factor localization in the adult. Am J Pathol. 2006 Feb; 168(2):639-48. PMID: 16436677.
    Citations: 95     Fields:    Translation:AnimalsCells
  84. Suburo AM, D'Amore PA. Development of the endothelium. Handb Exp Pharmacol. 2006; (176 Pt 1):71-105. PMID: 16999217.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  85. Maruyama K, Ii M, Cursiefen C, Jackson DG, Keino H, Tomita M, Van Rooijen N, Takenaka H, D'Amore PA, Stein-Streilein J, Losordo DW, Streilein JW. Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J Clin Invest. 2005 Sep; 115(9):2363-72. PMID: 16138190.
    Citations: 247     Fields:    Translation:AnimalsCells
  86. Detwiller KY, Fernando NT, Segal NH, Ryeom SW, D'Amore PA, Yoon SS. Analysis of hypoxia-related gene expression in sarcomas and effect of hypoxia on RNA interference of vascular endothelial cell growth factor A. Cancer Res. 2005 Jul 01; 65(13):5881-9. PMID: 15994966.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  87. Levenberg S, Rouwkema J, Macdonald M, Garfein ES, Kohane DS, Darland DC, Marini R, van Blitterswijk CA, Mulligan RC, D'Amore PA, Langer R. Engineering vascularized skeletal muscle tissue. Nat Biotechnol. 2005 Jul; 23(7):879-84. PMID: 15965465.
    Citations: 313     Fields:    Translation:HumansAnimalsCells
  88. Arboleda-Velasquez JF, Rampal R, Fung E, Darland DC, Liu M, Martinez MC, Donahue CP, Navarro-Gonzalez MF, Libby P, D'Amore PA, Aikawa M, Haltiwanger RS, Kosik KS. CADASIL mutations impair Notch3 glycosylation by Fringe. Hum Mol Genet. 2005 Jun 15; 14(12):1631-9. PMID: 15857853.
    Citations: 15     Fields:    Translation:AnimalsCells
  89. Loureiro RM, D'Amore PA. Transcriptional regulation of vascular endothelial growth factor in cancer. Cytokine Growth Factor Rev. 2005 Feb; 16(1):77-89. PMID: 15733833.
    Citations: 46     Fields:    Translation:AnimalsCells
  90. Loureiro RM, Maharaj AS, Dankort D, Muller WJ, D'Amore PA. ErbB2 overexpression in mammary cells upregulates VEGF through the core promoter. Biochem Biophys Res Commun. 2005 Jan 14; 326(2):455-65. PMID: 15582599.
    Citations: 12     Fields:    Translation:AnimalsCells
  91. Runnels JM, Poureshagh M, Novak J, D'Amore PA. Detection of circulating endothelial precursor cells by in vivo flow cytometry. IOVS. 2005.
  92. Nishijimam K, Jo N, Ng Y-S, Robinson GS, D'Amore PA, Shima DT, Adamis AP. VEGF 164 governs leukocyte dynamics and pathological neovascularization. IOVS. 2005.
  93. Darland DC, Saint-Geniez M, Chen J, Benezra R, D'Amore PA. Expression of ld 1 protein in developing retinal vasculature. IOVS. 2005.
  94. Morris PN, Dunmore BJ, Tadros A, Marchuk DA, Darland DC, D'Amore PA, Brindle NP. Functional analysis of a mutant form of the receptor tyrosine kinase Tie2 causing venous malformations. J Mol Med (Berl). 2005 Jan; 83(1):58-63. PMID: 15526080.
    Citations: 14     Fields:    Translation:HumansCells
  95. Ding R, Darland DC, Parmacek MS, D'Amore PA. Endothelial-mesenchymal interactions in vitro reveal molecular mechanisms of smooth muscle/pericyte differentiation. Stem Cells Dev. 2004 Oct; 13(5):509-20. PMID: 15588508.
    Citations: 24     Fields:    Translation:AnimalsCells
  96. Ng YS, Ramsauer M, Loureiro RM, D'Amore PA. Identification of genes involved in VEGF-mediated vascular morphogenesis using embryonic stem cell-derived cystic embryoid bodies. Lab Invest. 2004 Sep; 84(9):1209-18. PMID: 15220937.
    Citations: 20     Fields:    Translation:AnimalsCells
  97. Garcia CM, Darland DC, Massingham LJ, D'Amore PA. Endothelial cell-astrocyte interactions and TGF beta are required for induction of blood-neural barrier properties. Brain Res Dev Brain Res. 2004 Aug 18; 152(1):25-38. PMID: 15283992.
    Citations: 38     Fields:    Translation:AnimalsCells
  98. Chang R, Andreoli S, Ng YS, Truong T, Smith SR, Wilson J, D'Amore PA. VEGF expression is downregulated in nitrofen-induced congenital diaphragmatic hernia. J Pediatr Surg. 2004 Jun; 39(6):825-8; discussion 825-8. PMID: 15185205.
    Citations: 14     Fields:    Translation:AnimalsCells
  99. Cursiefen C, Chen L, Borges LP, Jackson D, Cao J, Radziejewski C, D'Amore PA, Dana MR, Wiegand SJ, Streilein JW. VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. J Clin Invest. 2004 Apr; 113(7):1040-50. PMID: 15057311.
    Citations: 352     Fields:    Translation:AnimalsCells
  100. Beck LH, Goodwin AM, D'Amore PA. Culture of large vessel endothelial cells on floating collagen gels promotes a phenotype characteristic of endothelium in vivo. Differentiation. 2004 Apr; 72(4):162-70. PMID: 15157239.
    Citations: 2     Fields:    Translation:HumansCells
  101. Saint-Geniez M, D'Amore PA. Development and pathology of the hyaloid, choroidal and retinal vasculature. Int J Dev Biol. 2004; 48(8-9):1045-58. PMID: 15558494.
    Citations: 141     Fields:    Translation:HumansAnimals
  102. Darland DC, Massingham LJ, Smith SR, Piek E, Saint-Geniez M, D'Amore PA. Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. Dev Biol. 2003 Dec 01; 264(1):275-88. PMID: 14623248.
    Citations: 138     Fields:    Translation:HumansAnimalsCells
  103. Hartnett ME, Lappas A, Darland D, McColm JR, Lovejoy S, D'Amore PA. Retinal pigment epithelium and endothelial cell interaction causes retinal pigment epithelial barrier dysfunction via a soluble VEGF-dependent mechanism. Exp Eye Res. 2003 Nov; 77(5):593-9. PMID: 14550401.
    Citations: 33     Fields:    Translation:AnimalsCells
  104. Ishida S, Usui T, Yamashiro K, Kaji Y, Amano S, Ogura Y, Hida T, Oguchi Y, Ambati J, Miller JW, Gragoudas ES, Ng YS, D'Amore PA, Shima DT, Adamis AP. VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization. J Exp Med. 2003 Aug 04; 198(3):483-9. PMID: 12900522.
    Citations: 131     Fields:    Translation:AnimalsCells
  105. Ramsauer M, D'Amore PA. Getting Tie(2)d up in angiogenesis. J Clin Invest. 2002 Dec; 110(11):1615-7. PMID: 12464666.
    Citations: 22     Fields:    Translation:Humans
  106. D'Amore PA, Ng YS. Won't you be my neighbor? Local induction of arteriogenesis. Cell. 2002 Aug 09; 110(3):289-92. PMID: 12176316.
    Citations: 11     Fields:    Translation:HumansAnimals
  107. Galambos C, Ng YS, Ali A, Noguchi A, Lovejoy S, D'Amore PA, DeMello DE. Defective pulmonary development in the absence of heparin-binding vascular endothelial growth factor isoforms. Am J Respir Cell Mol Biol. 2002 Aug; 27(2):194-203. PMID: 12151311.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  108. D'Amore PA, Ng YS. Tales of the cryptic: unveiling more angiogenesis inhibitors. Trends Mol Med. 2002 Jul; 8(7):313-5. PMID: 12114105.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  109. Zelzer E, McLean W, Ng YS, Fukai N, Reginato AM, Lovejoy S, D'Amore PA, Olsen BR. Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development. 2002 Apr; 129(8):1893-904. PMID: 11934855.
    Citations: 123     Fields:    Translation:AnimalsCells
  110. Stalmans I, Ng YS, Rohan R, Fruttiger M, Bouché A, Yuce A, Fujisawa H, Hermans B, Shani M, Jansen S, Hicklin D, Anderson DJ, Gardiner T, Hammes HP, Moons L, Dewerchin M, Collen D, Carmeliet P, D'Amore PA. Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J Clin Invest. 2002 Feb; 109(3):327-36. PMID: 11827992.
    Citations: 158     Fields:    Translation:AnimalsCells
  111. Goodwin AM, D'Amore PA. Wnt signaling in the vasculature. Angiogenesis. 2002; 5(1-2):1-9. PMID: 12549854.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  112. Ng YS, Rohan R, Sunday ME, Demello DE, D'Amore PA. Differential expression of VEGF isoforms in mouse during development and in the adult. Dev Dyn. 2001 Feb; 220(2):112-21. PMID: 11169844.
    Citations: 127     Fields:    Translation:AnimalsCells
  113. Darland DC, D'Amore PA. TGF beta is required for the formation of capillary-like structures in three-dimensional cocultures of 10T1/2 and endothelial cells. Angiogenesis. 2001; 4(1):11-20. PMID: 11824373.
    Citations: 54     Fields:    Translation:AnimalsCells
  114. Darland DC, D'Amore PA. Cell-cell interactions in vascular development. Curr Top Dev Biol. 2001; 52:107-49. PMID: 11529428.
    Citations: 39     Fields:    Translation:AnimalsCells
  115. Nguyen LL, D'Amore PA. Cellular interactions in vascular growth and differentiation. Int Rev Cytol. 2001; 204:1-48. PMID: 11243594.
    Citations: 13     Fields:    Translation:HumansAnimals
  116. Ng YS, D'Amore PA. Therapeutic angiogenesis for cardiovascular disease. Curr Control Trials Cardiovasc Med. 2001; 2(6):278-285. PMID: 11806814.
    Citations: 10     
  117. D'Amore PA. Kissing cousins-evidence for a common vascular cell precursor. Nat Med. 2000 Dec; 6(12):1323-4. PMID: 11100113.
    Citations: 2     Fields:    Translation:Cells
  118. Dennis S, Aikawa M, Szeto W, d'Amore PA, Papkoff J. A secreted frizzled related protein, FrzA, selectively associates with Wnt-1 protein and regulates wnt-1 signaling. J Cell Sci. 1999 Nov; 112 ( Pt 21):3815-20. PMID: 10523516.
    Citations: 29     Fields:    Translation:Cells
  119. Hartnett ME, Garcia CM, D'Amore PA. Release of bFGF, an endothelial cell survival factor, by osmotic shock. Invest Ophthalmol Vis Sci. 1999 Nov; 40(12):2945-51. PMID: 10549656.
    Citations: 3     Fields:    Translation:AnimalsCells
  120. Grosskreutz CL, Anand-Apte B, Dupláa C, Quinn TP, Terman BI, Zetter B, D'Amore PA. Vascular endothelial growth factor-induced migration of vascular smooth muscle cells in vitro. Microvasc Res. 1999 Sep; 58(2):128-36. PMID: 10458928.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  121. Duplàa C, Jaspard B, Moreau C, D'Amore PA. Identification and cloning of a secreted protein related to the cysteine-rich domain of frizzled. Evidence for a role in endothelial cell growth control. Circ Res. 1999 Jun 25; 84(12):1433-45. PMID: 10381896.
    Citations: 16     Fields:    Translation:AnimalsCells
  122. Carmeliet P, Ng YS, Nuyens D, Theilmeier G, Brusselmans K, Cornelissen I, Ehler E, Kakkar VV, Stalmans I, Mattot V, Perriard JC, Dewerchin M, Flameng W, Nagy A, Lupu F, Moons L, Collen D, D'Amore PA, Shima DT. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nat Med. 1999 May; 5(5):495-502. PMID: 10229225.
    Citations: 153     Fields:    Translation:AnimalsCells
  123. Hirschi KK, Rohovsky SA, Beck LH, Smith SR, D'Amore PA. Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact. Circ Res. 1999 Feb 19; 84(3):298-305. PMID: 10024303.
    Citations: 99     Fields:    Translation:AnimalsCells
  124. Darland DC, D'Amore PA. Blood vessel maturation: vascular development comes of age. J Clin Invest. 1999 Jan; 103(2):157-8. PMID: 9916126.
    Citations: 63     Fields:    
  125. Xu Q, D'Amore PA, Sokol SY. Functional and biochemical interactions of Wnts with FrzA, a secreted Wnt antagonist. Development. 1998 Dec; 125(23):4767-76. PMID: 9806925.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  126. Hirschi KK, Rohovsky SA, D'Amore PA. PDGF, TGF-beta, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate. J Cell Biol. 1998 May 04; 141(3):805-14. PMID: 9566978.
    Citations: 249     Fields:    Translation:Animals
  127. Hirschi KK, Rohovsky SA, D'Amore PA. Cell-cell interactions in vessel assembly: a model for the fundamentals of vascular remodelling. Transpl Immunol. 1997 Sep; 5(3):177-8. PMID: 9402682.
    Citations: 12     Fields:    Translation:HumansAnimals
  128. Beck L, D'Amore PA. Vascular development: cellular and molecular regulation. FASEB J. 1997 Apr; 11(5):365-73. PMID: 9141503.
    Citations: 89     Fields:    Translation:AnimalsCells
  129. Hirschi KK, D'Amore PA. Control of angiogenesis by the pericyte: molecular mechanisms and significance. EXS. 1997; 79:419-28. PMID: 9002230.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  130. Folkman J, D'Amore PA. Blood vessel formation: what is its molecular basis? Cell. 1996 Dec 27; 87(7):1153-5. PMID: 8980221.
    Citations: 218     Fields:    Translation:HumansAnimalsCells
  131. Rohovsky S, Kearney M, Pieczek A, Rosenfield K, Schainfeld R, D'Amore PA, Isner JM. Elevated levels of basic fibroblast growth factor in patients with limb ischemia. Am Heart J. 1996 Nov; 132(5):1015-9. PMID: 8892777.
    Citations: 2     Fields:    Translation:HumansCells
  132. Hirschi KK, D'Amore PA. Pericytes in the microvasculature. Cardiovasc Res. 1996 Oct; 32(4):687-98. PMID: 8915187.
    Citations: 216     Fields:    Translation:HumansAnimalsCells
  133. Klagsbrun M, D'Amore PA. Vascular endothelial growth factor and its receptors. Cytokine Growth Factor Rev. 1996 Oct; 7(3):259-70. PMID: 8971481.
    Citations: 71     Fields:    Translation:HumansAnimals
  134. Luo Y, D'Amore PA, Dorf ME. Beta-chemokine TCA3 binds to and activates rat vascular smooth muscle cells. J Immunol. 1996 Sep 01; 157(5):2143-8. PMID: 8757339.
    Citations: 4     Fields:    Translation:AnimalsCells