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Last Name

profileKlaus J. van Leyen, PH.D.

TitleAssociate Professor of Radiology
InstitutionMassachusetts General Hospital
AddressMassachusetts General Hospital
Radiology-CNY149-Rm 2401
149 13th Street
Charlestown MA 02129
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21NS087165     (VAN LEYEN, KLAUS)May 15, 2014 - Apr 30, 2016
Novel 12/15 lipoxygenase inhibitors for the treatment of stroke
Role: Principal Investigator

R01NS069939     (VAN LEYEN, KLAUS)Aug 1, 2011 - May 31, 2014
Effects of Semaphorin 3A on Stroke Recovery
Role: Principal Investigator

R01NS049430     (VAN LEYEN, KLAUS)Jul 1, 2004 - May 31, 2016
12/15-Lipoxygenase and neurovascular damage following cardiac arrest
Role: Principal Investigator

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Fan X, Jiang Y, Yu Z, Liu Q, Guo S, Sun X, van Leyen K, Ning M, Gao X, Lo EH, Wang X. Annexin A2 Plus Low-Dose Tissue Plasminogen Activator Combination Attenuates Cerebrovascular Dysfunction After Focal Embolic Stroke of Rats. Transl Stroke Res. 2017 Jun 04. PMID: 28580536.
    View in: PubMed
  2. Maher P, van Leyen K, Dey PN, Honrath B, Dolga A, Methner A. The role of Ca2+ in cell death caused by oxidative glutamate toxicity and ferroptosis. Cell Calcium. 2017 May 12. PMID: 28545724.
    View in: PubMed
  3. Liu Y, Zheng Y, Karatas H, Wang X, Foerch C, Lo EH, van Leyen K. 12/15-Lipoxygenase Inhibition or Knockout Reduces Warfarin-Associated Hemorrhagic Transformation After Experimental Stroke. Stroke. 2017 Feb; 48(2):445-451. PMID: 28057806.
    View in: PubMed
  4. Zhao S, Yu Z, Liu Y, Bai Y, Jiang Y, van Leyen K, Yang YG, Lok JM, Whalen MJ, Lo EH, Wang X. CD47 deficiency improves neurological outcomes of traumatic brain injury in mice. Neurosci Lett. 2017 Mar 16; 643:125-130. PMID: 27931776.
    View in: PubMed
  5. Yigitkanli K, Zheng Y, Pekcec A, Lo EH, van Leyen K. Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia. Transl Stroke Res. 2017 Apr; 8(2):194-202. PMID: 27838820.
    View in: PubMed
  6. Armstrong MM, Freedman CJ, Jung JE, Zheng Y, Kalyanaraman C, Jacobson MP, Simeonov A, Maloney DJ, van Leyen K, Jadhav A, Holman TR. A potent and selective inhibitor targeting human and murine 12/15-LOX. Bioorg Med Chem. 2016 Mar 15; 24(6):1183-90. PMID: 26899595; PMCID: PMC4778748 [Available on 03/15/17].
  7. van Leyen K, Arai K, Wang X, Lo EH. From cell to cell: the breakdown of intercellular connectivity after stroke and how to regain contact. Brain Res. 2015 Oct 14; 1623:1-2. PMID: 26363519.
    View in: PubMed
  8. Jiang Y, Fan X, Yu Z, Liao Z, Wang XS, van Leyen K, Sun X, Lo EH, Wang X. Combination Low-Dose Tissue-Type Plasminogen Activator Plus Annexin A2 for Improving Thrombolytic Stroke Therapy. Front Cell Neurosci. 2015; 9:397. PMID: 26528130; PMCID: PMC4604305.
  9. Hayakawa K, Pham LD, Seo JH, Miyamoto N, Maki T, Terasaki Y, Sakadžic S, Boas D, van Leyen K, Waeber C, Kim KW, Arai K, Lo EH. CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation. J Cereb Blood Flow Metab. 2016 Apr; 36(4):781-93. PMID: 26661156; PMCID: PMC4821018 [Available on 04/01/17].
  10. Jung JE, Karatas H, Liu Y, Yalcin A, Montaner J, Lo EH, van Leyen K. STAT-dependent upregulation of 12/15-lipoxygenase contributes to neuronal injury after stroke. J Cereb Blood Flow Metab. 2015 Dec; 35(12):2043-51. PMID: 26174325; PMCID: PMC4671126 [Available on 12/01/16].
  11. Hotokezaka Y, Katayama I, van Leyen K, Nakamura T. GSK-3ß-dependent downregulation of ?-taxilin and aNAC merge to regulate ER stress responses. Cell Death Dis. 2015 Apr 16; 6:e1719. PMID: 25880086; PMCID: PMC4650556.
  12. Kuhn H, Banthiya S, van Leyen K. Mammalian lipoxygenases and their biological relevance. Biochim Biophys Acta. 2015 Apr; 1851(4):308-30. PMID: 25316652; PMCID: PMC4370320.
  13. Xing C, Wang X, Cheng C, Montaner J, Mandeville E, Leung W, van Leyen K, Lok J, Wang X, Lo EH. Neuronal production of lipocalin-2 as a help-me signal for glial activation. Stroke. 2014 Jul; 45(7):2085-92. PMID: 24916903; PMCID: PMC4122238.
  14. Rai G, Joshi N, Jung JE, Liu Y, Schultz L, Yasgar A, Perry S, Diaz G, Zhang Q, Kenyon V, Jadhav A, Simeonov A, Lo EH, van Leyen K, Maloney DJ, Holman TR. Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J Med Chem. 2014 May 22; 57(10):4035-48. PMID: 24684213; PMCID: PMC4033661.
  15. Liu Q, Qiu J, Liang M, Golinski J, van Leyen K, Jung JE, You Z, Lo EH, Degterev A, Whalen MJ. Akt and mTOR mediate programmed necrosis in neurons. Cell Death Dis. 2014 Feb 27; 5:e1084. PMID: 24577082; PMCID: PMC3944276.
  16. Schaefer JH, Leung W, Wu L, Van Cott EM, Lok J, Whalen M, van Leyen K, Lauer A, van Ryn J, Lo EH, Foerch C. Translational insights into traumatic brain injury occurring during dabigatran or warfarin anticoagulation. J Cereb Blood Flow Metab. 2014 May; 34(5):870-5. PMID: 24549187; PMCID: PMC4013768.
  17. van Leyen K, Holman TR, Maloney DJ. The potential of 12/15-lipoxygenase inhibitors in stroke therapy. Future Med Chem. 2014; 6(17):1853-5. PMID: 25495979; PMCID: PMC4280907.
  18. Jang I, Park S, Cho JW, Yigitkanli K, van Leyen K, Roth J. Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy. Exp Cell Res. 2014 Feb 15; 321(2):276-87. PMID: 24291223.
    View in: PubMed
  19. Haynes RL, van Leyen K. 12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia. Dev Neurosci. 2013; 35(2-3):140-54. PMID: 23838566; PMCID: PMC3860095.
  20. van Leyen K. Lipoxygenase: an emerging target for stroke therapy. CNS Neurol Disord Drug Targets. 2013 Mar; 12(2):191-9. PMID: 23394536; PMCID: PMC3676892.
  21. Foerch C, Rosidi NL, Schlunk F, Lauer A, Cianchetti FA, Mandeville E, Arai K, Yigitkanli K, Fan X, Wang X, van Leyen K, Steinmetz H, Schaffer CB, Lo EH. Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice. PLoS One. 2013; 8(2):e54203. PMID: 23408937; PMCID: PMC3568130.
  22. Yigitkanli K, Pekcec A, Karatas H, Pallast S, Mandeville E, Joshi N, Smirnova N, Gazaryan I, Ratan RR, Witztum JL, Montaner J, Holman TR, Lo EH, van Leyen K. Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke. Ann Neurol. 2013 Jan; 73(1):129-35. PMID: 23192915; PMCID: PMC3563836.
  23. Pekcec A, Yigitkanli K, Jung JE, Pallast S, Xing C, Antipenko A, Minchenko M, Nikolov DB, Holman TR, Lo EH, van Leyen K. Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling. FASEB J. 2013 Feb; 27(2):437-45. PMID: 23070608; PMCID: PMC3545523.
  24. Marutani E, Kosugi S, Tokuda K, Khatri A, Nguyen R, Atochin DN, Kida K, Van Leyen K, Arai K, Ichinose F. A novel hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonist prevents ischemic neuronal death. J Biol Chem. 2012 Sep 14; 287(38):32124-35. PMID: 22815476; PMCID: PMC3442543.
  25. Yu Z, Xu J, Liu N, Wang Y, Li X, Pallast S, van Leyen K, Wang X. Mitochondrial distribution of neuroglobin and its response to oxygen-glucose deprivation in primary-cultured mouse cortical neurons. Neuroscience. 2012 Aug 30; 218:235-42. PMID: 22659017; PMCID: PMC3394186.
  26. van Leyen K, Klötzsch C, Harrer JU. Brain tumor imaging with transcranial sonography: state of the art and review of the literature. Ultraschall Med. 2011 Dec; 32(6):572-81. PMID: 22033868.
    View in: PubMed
  27. Lok J, Leung W, Zhao S, Pallast S, van Leyen K, Guo S, Wang X, Yalcin A, Lo EH. ?-glutamylcysteine ethyl ester protects cerebral endothelial cells during injury and decreases blood-brain barrier permeability after experimental brain trauma. J Neurochem. 2011 Jul; 118(2):248-55. PMID: 21534958; PMCID: PMC3285992.
  28. Kan MC, Oruganty-Das A, Cooper-Morgan A, Jin G, Swanger SA, Bassell GJ, Florman H, van Leyen K, Richter JD. CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion. Mol Cell Biol. 2010 Dec; 30(24):5658-71. PMID: 20937770; PMCID: PMC3004280.
  29. Moore K, Lovercamp K, Feng D, Antelman J, Sutovsky M, Manandhar G, van Leyen K, Safranski T, Sutovsky P. Altered epididymal sperm maturation and cytoplasmic droplet migration in subfertile male Alox15 mice. Cell Tissue Res. 2010 Jun; 340(3):569-81. PMID: 20449608.
    View in: PubMed
  30. Pallast S, Arai K, Pekcec A, Yigitkanli K, Yu Z, Wang X, Lo EH, van Leyen K. Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1157-67. PMID: 20068575; PMCID: PMC2915762.
  31. Tejima E, Guo S, Murata Y, Arai K, Lok J, van Leyen K, Rosell A, Wang X, Lo EH. Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1. J Neurotrauma. 2009 Nov; 26(11):1935-41. PMID: 19469687; PMCID: PMC2822804.
  32. Lee BJ, Egi Y, van Leyen K, Lo EH, Arai K. Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro. Brain Res. 2010 Jan 11; 1307:22-7. PMID: 19840779; PMCID: PMC2797401.
  33. Pallast S, Arai K, Wang X, Lo EH, van Leyen K. 12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress. J Neurochem. 2009 Nov; 111(3):882-9. PMID: 19737346; PMCID: PMC2773137.
  34. Hotokezaka Y, van Leyen K, Lo EH, Beatrix B, Katayama I, Jin G, Nakamura T. alphaNAC depletion as an initiator of ER stress-induced apoptosis in hypoxia. Cell Death Differ. 2009 Nov; 16(11):1505-14. PMID: 19609276.
    View in: PubMed
  35. Gautschi OP, van Leyen K, Cadosch D, Hildebrandt G, Fournier JY. [Fluorescence guided resection of malignant brain tumors - breakthrough in the surgery of brain tumors]. Praxis (Bern 1994). 2009 Jun 10; 98(12):643-7. PMID: 19513974.
    View in: PubMed
  36. Foerch C, Arai K, Van Cott EM, van Leyen K, Lo EH. Rapid reversal of anticoagulation reduces hemorrhage volume in a mouse model of warfarin-associated intracerebral hemorrhage. J Cereb Blood Flow Metab. 2009 May; 29(5):1015-21. PMID: 19319147; PMCID: PMC3691988.
  37. Foerch C, Arai K, Jin G, Park KP, Pallast S, van Leyen K, Lo EH. Experimental model of warfarin-associated intracerebral hemorrhage. Stroke. 2008 Dec; 39(12):3397-404. PMID: 18772448; PMCID: PMC3712841.
  38. Jin G, Arai K, Murata Y, Wang S, Stins MF, Lo EH, van Leyen K. Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia. Stroke. 2008 Sep; 39(9):2538-43. PMID: 18635843; PMCID: PMC2754072.
  39. van Leyen K, Arai K, Jin G, Kenyon V, Gerstner B, Rosenberg PA, Holman TR, Lo EH. Novel lipoxygenase inhibitors as neuroprotective reagents. J Neurosci Res. 2008 Mar; 86(4):904-9. PMID: 17960827; PMCID: PMC2759176.
  40. Lok J, Gupta P, Guo S, Kim WJ, Whalen MJ, van Leyen K, Lo EH. Cell-cell signaling in the neurovascular unit. Neurochem Res. 2007 Dec; 32(12):2032-45. PMID: 17457674.
    View in: PubMed
  41. van Leyen K, Kim HY, Lee SR, Jin G, Arai K, Lo EH. Baicalein and 12/15-lipoxygenase in the ischemic brain. Stroke. 2006 Dec; 37(12):3014-8. PMID: 17053180.
    View in: PubMed
  42. Tejima E, Zhao BQ, Tsuji K, Rosell A, van Leyen K, Gonzalez RG, Montaner J, Wang X, Lo EH. Astrocytic induction of matrix metalloproteinase-9 and edema in brain hemorrhage. J Cereb Blood Flow Metab. 2007 Mar; 27(3):460-8. PMID: 16788715.
    View in: PubMed
  43. Fischer KA, Van Leyen K, Lovercamp KW, Manandhar G, Sutovsky M, Feng D, Safranski T, Sutovsky P. 15-Lipoxygenase is a component of the mammalian sperm cytoplasmic droplet. Reproduction. 2005 Aug; 130(2):213-22. PMID: 16049159.
    View in: PubMed
  44. Black VH, Sanjay A, van Leyen K, Lauring B, Kreibich G. Cholesterol and steroid synthesizing smooth endoplasmic reticulum of adrenocortical cells contains high levels of proteins associated with the translocation channel. Endocrinology. 2005 Oct; 146(10):4234-49. PMID: 15947003.
    View in: PubMed
  45. van Leyen K, Siddiq A, Ratan RR, Lo EH. Proteasome inhibition protects HT22 neuronal cells from oxidative glutamate toxicity. J Neurochem. 2005 Feb; 92(4):824-30. PMID: 15686484; PMCID: PMC2570092.
  46. Arai K, Lee SR, van Leyen K, Kurose H, Lo EH. Involvement of ERK MAP kinase in endoplasmic reticulum stress in SH-SY5Y human neuroblastoma cells. J Neurochem. 2004 Apr; 89(1):232-9. PMID: 15030407.
    View in: PubMed
  47. Sutovsky P, Van Leyen K, McCauley T, Day BN, Sutovsky M. Degradation of paternal mitochondria after fertilization: implications for heteroplasmy, assisted reproductive technologies and mtDNA inheritance. Reprod Biomed Online. 2004 Jan; 8(1):24-33. PMID: 14759284.
    View in: PubMed
  48. Antipenko A, Himanen JP, van Leyen K, Nardi-Dei V, Lesniak J, Barton WA, Rajashankar KR, Lu M, Hoemme C, Püschel AW, Nikolov DB. Structure of the semaphorin-3A receptor binding module. Neuron. 2003 Aug 14; 39(4):589-98. PMID: 12925274.
    View in: PubMed
  49. Black VH, Sanjay A, van Leyen K, Möeller I, Lauring B, Kreibich G. Cholesterol and steroid synthesizing smooth endoplasmic reticulum of adrenocortical cells contains high levels of translocation apparatus proteins. Endocr Res. 2002 Nov; 28(4):425-30. PMID: 12530645.
    View in: PubMed
  50. Hotokezaka Y, Tobben U, Hotokezaka H, Van Leyen K, Beatrix B, Smith DH, Nakamura T, Wiedmann M. Interaction of the eukaryotic elongation factor 1A with newly synthesized polypeptides. J Biol Chem. 2002 May 24; 277(21):18545-51. PMID: 11893745.
    View in: PubMed
  51. Grüllich C, Duvoisin RM, Wiedmann M, van Leyen K. Inhibition of 15-lipoxygenase leads to delayed organelle degradation in the reticulocyte. FEBS Lett. 2001 Jan 26; 489(1):51-4. PMID: 11231012.
    View in: PubMed
  52. Pierce JP, van Leyen K, McCarthy JB. Translocation machinery for synthesis of integral membrane and secretory proteins in dendritic spines. Nat Neurosci. 2000 Apr; 3(4):311-3. PMID: 10725917.
    View in: PubMed
  53. Rush JS, van Leyen K, Ouerfelli O, Wolucka B, Waechter CJ. Transbilayer movement of Glc-P-dolichol and its function as a glucosyl donor: protein-mediated transport of a water-soluble analog into sealed ER vesicles from pig brain. Glycobiology. 1998 Dec; 8(12):1195-205. PMID: 9858641.
    View in: PubMed
  54. van Leyen K. Pictures in cell biology. Un-LOXing the door to organelle degradation. Trends Cell Biol. 1998 Nov; 8(11):436. PMID: 9854309.
    View in: PubMed
  55. van Leyen K, Duvoisin RM, Engelhardt H, Wiedmann M. A function for lipoxygenase in programmed organelle degradation. Nature. 1998 Sep 24; 395(6700):392-5. PMID: 9759730.
    View in: PubMed
  56. Suhm N, Dams J, van Leyen K, Lorenz A, Bendl R. Limitations for three-dimensional ultrasound imaging through a bore-hole trepanation. Ultrasound Med Biol. 1998 Jun; 24(5):663-71. PMID: 9695269.
    View in: PubMed
  57. van Leyen K, Widemann M, Wieland F. Glycotripeptides are released by yeast but not by mammalian microsomes. FEBS Lett. 1994 Nov 28; 355(2):147-50. PMID: 7982488.
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  58. van Leyen K, Wieland F. Complete Golgi passage of glycotripeptides generated in the endoplasmic reticulum of mammalian cells. FEBS Lett. 1994 Sep 26; 352(2):211-5. PMID: 7925975.
    View in: PubMed
  59. Jaenicke L, van Leyen K, Siegmund HU. Dolichyl phosphate-dependent glycosyltransferases utilize truncated cofactors. Biol Chem Hoppe Seyler. 1991 Nov; 372(11):1021-6. PMID: 1724374.
    View in: PubMed
  60. Sanker P, Richard KE, Weigl HC, Klug N, van Leyen K. Transcranial Doppler sonography and intracranial pressure monitoring in children and juveniles with acute brain injuries or hydrocephalus. Childs Nerv Syst. 1991 Nov; 7(7):391-3. PMID: 1794119.
    View in: PubMed
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