Harvard Catalyst Profiles

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Klaus J. van Leyen, PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. UG3NS106854 (VAN LEYEN, KLAUS) May 15, 2018 - Apr 30, 2019
    NIH/NINDS
    Development of human 12/15-lipoxygenase therapeutics for stroke
    Role: Principal Investigator
  2. R21NS087165 (VAN LEYEN, KLAUS) May 15, 2014 - Apr 30, 2016
    NIH/NINDS
    Novel 12/15 lipoxygenase inhibitors for the treatment of stroke
    Role: Principal Investigator
  3. R01NS069939 (VAN LEYEN, KLAUS) Aug 1, 2011 - May 31, 2014
    NIH/NINDS
    Effects of Semaphorin 3A on Stroke Recovery
    Role: Principal Investigator
  4. R01NS049430 (VAN LEYEN, KLAUS) Jul 1, 2004 - May 31, 2016
    NIH/NINDS
    12/15-Lipoxygenase and neurovascular damage following cardiac arrest
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gaberel T, Gakuba C, Zheng Y, Lépine M, Lo EH, van Leyen K. Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage. Stroke. 2019 Feb; 50(2):520-523. PMID: 30602353.
    Citations:    Fields:    
  2. Karatas H, Eun Jung J, Lo EH, van Leyen K. Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models. Brain Res. 2018 Jan 01; 1678:123-128. PMID: 29079502.
    Citations: 1     Fields:    Translation:Animals
  3. Fan X, Jiang Y, Yu Z, Liu Q, Guo S, Sun X, van Leyen K, Ning M, Gao X, Lo EH, Wang X. Annexin A2 Plus Low-Dose Tissue Plasminogen Activator Combination Attenuates Cerebrovascular Dysfunction After Focal Embolic Stroke of Rats. Transl Stroke Res. 2017 12; 8(6):549-559. PMID: 28580536.
    Citations: 2     Fields:    Translation:Animals
  4. Maher P, van Leyen K, Dey PN, Honrath B, Dolga A, Methner A. The role of Ca2+ in cell death caused by oxidative glutamate toxicity and ferroptosis. Cell Calcium. 2018 03; 70:47-55. PMID: 28545724.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Liu Y, Zheng Y, Karatas H, Wang X, Foerch C, Lo EH, van Leyen K. 12/15-Lipoxygenase Inhibition or Knockout Reduces Warfarin-Associated Hemorrhagic Transformation After Experimental Stroke. Stroke. 2017 02; 48(2):445-451. PMID: 28057806.
    Citations: 2     Fields:    Translation:Animals
  6. Zhao S, Yu Z, Liu Y, Bai Y, Jiang Y, van Leyen K, Yang YG, Lok JM, Whalen MJ, Lo EH, Wang X. CD47 deficiency improves neurological outcomes of traumatic brain injury in mice. Neurosci Lett. 2017 03 16; 643:125-130. PMID: 27931776.
    Citations:    Fields:    Translation:Animals
  7. Yigitkanli K, Zheng Y, Pekcec A, Lo EH, van Leyen K. Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia. Transl Stroke Res. 2017 04; 8(2):194-202. PMID: 27838820.
    Citations: 7     Fields:    Translation:AnimalsCells
  8. Armstrong MM, Freedman CJ, Jung JE, Zheng Y, Kalyanaraman C, Jacobson MP, Simeonov A, Maloney DJ, van Leyen K, Jadhav A, Holman TR. A potent and selective inhibitor targeting human and murine 12/15-LOX. Bioorg Med Chem. 2016 Mar 15; 24(6):1183-90. PMID: 26899595; PMCID: PMC4778748.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  9. van Leyen K, Arai K, Wang X, Lo EH. From cell to cell: the breakdown of intercellular connectivity after stroke and how to regain contact. Brain Res. 2015 Oct 14; 1623:1-2. PMID: 26363519.
    Citations: 1     Fields:    Translation:Humans
  10. Jiang Y, Fan X, Yu Z, Liao Z, Wang XS, van Leyen K, Sun X, Lo EH, Wang X. Combination Low-Dose Tissue-Type Plasminogen Activator Plus Annexin A2 for Improving Thrombolytic Stroke Therapy. Front Cell Neurosci. 2015; 9:397. PMID: 26528130; PMCID: PMC4604305.
    Citations: 3     
  11. Hayakawa K, Pham LD, Seo JH, Miyamoto N, Maki T, Terasaki Y, Sakadžic S, Boas D, van Leyen K, Waeber C, Kim KW, Arai K, Lo EH. CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation. J Cereb Blood Flow Metab. 2016 Apr; 36(4):781-93. PMID: 26661156.
    Citations: 6     Fields:    Translation:AnimalsCells
  12. Jung JE, Karatas H, Liu Y, Yalcin A, Montaner J, Lo EH, van Leyen K. STAT-dependent upregulation of 12/15-lipoxygenase contributes to neuronal injury after stroke. J Cereb Blood Flow Metab. 2015 Dec; 35(12):2043-51. PMID: 26174325; PMCID: PMC4671126.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Hotokezaka Y, Katayama I, van Leyen K, Nakamura T. GSK-3ß-dependent downregulation of ?-taxilin and aNAC merge to regulate ER stress responses. Cell Death Dis. 2015 Apr 16; 6:e1719. PMID: 25880086; PMCID: PMC4650556.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  14. Kuhn H, Banthiya S, van Leyen K. Mammalian lipoxygenases and their biological relevance. Biochim Biophys Acta. 2015 Apr; 1851(4):308-30. PMID: 25316652; PMCID: PMC4370320.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  15. Xing C, Wang X, Cheng C, Montaner J, Mandeville E, Leung W, van Leyen K, Lok J, Wang X, Lo EH. Neuronal production of lipocalin-2 as a help-me signal for glial activation. Stroke. 2014 Jul; 45(7):2085-92. PMID: 24916903; PMCID: PMC4122238.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  16. Rai G, Joshi N, Jung JE, Liu Y, Schultz L, Yasgar A, Perry S, Diaz G, Zhang Q, Kenyon V, Jadhav A, Simeonov A, Lo EH, van Leyen K, Maloney DJ, Holman TR. Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J Med Chem. 2014 May 22; 57(10):4035-48. PMID: 24684213; PMCID: PMC4033661.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  17. Liu Q, Qiu J, Liang M, Golinski J, van Leyen K, Jung JE, You Z, Lo EH, Degterev A, Whalen MJ. Akt and mTOR mediate programmed necrosis in neurons. Cell Death Dis. 2014 Feb 27; 5:e1084. PMID: 24577082; PMCID: PMC3944276.
    Citations: 23     Fields:    Translation:AnimalsCells
  18. Schaefer JH, Leung W, Wu L, Van Cott EM, Lok J, Whalen M, van Leyen K, Lauer A, van Ryn J, Lo EH, Foerch C. Translational insights into traumatic brain injury occurring during dabigatran or warfarin anticoagulation. J Cereb Blood Flow Metab. 2014 May; 34(5):870-5. PMID: 24549187; PMCID: PMC4013768.
    Citations: 6     Fields:    Translation:Animals
  19. van Leyen K, Holman TR, Maloney DJ. The potential of 12/15-lipoxygenase inhibitors in stroke therapy. Future Med Chem. 2014; 6(17):1853-5. PMID: 25495979; PMCID: PMC4280907.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  20. Jang I, Park S, Cho JW, Yigitkanli K, van Leyen K, Roth J. Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy. Exp Cell Res. 2014 Feb 15; 321(2):276-87. PMID: 24291223.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  21. Haynes RL, van Leyen K. 12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia. Dev Neurosci. 2013; 35(2-3):140-54. PMID: 23838566; PMCID: PMC3860095.
    Citations: 6     Fields:    Translation:HumansCells
  22. van Leyen K. Lipoxygenase: an emerging target for stroke therapy. CNS Neurol Disord Drug Targets. 2013 Mar; 12(2):191-9. PMID: 23394536; PMCID: PMC3676892.
    Citations: 14     Fields:    Translation:HumansAnimals
  23. Foerch C, Rosidi NL, Schlunk F, Lauer A, Cianchetti FA, Mandeville E, Arai K, Yigitkanli K, Fan X, Wang X, van Leyen K, Steinmetz H, Schaffer CB, Lo EH. Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice. PLoS One. 2013; 8(2):e54203. PMID: 23408937; PMCID: PMC3568130.
    Citations: 3     Fields:    Translation:Animals
  24. Yigitkanli K, Pekcec A, Karatas H, Pallast S, Mandeville E, Joshi N, Smirnova N, Gazaryan I, Ratan RR, Witztum JL, Montaner J, Holman TR, Lo EH, van Leyen K. Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke. Ann Neurol. 2013 Jan; 73(1):129-35. PMID: 23192915.
    Citations: 30     Fields:    Translation:HumansAnimals
  25. Pekcec A, Yigitkanli K, Jung JE, Pallast S, Xing C, Antipenko A, Minchenko M, Nikolov DB, Holman TR, Lo EH, van Leyen K. Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling. FASEB J. 2013 Feb; 27(2):437-45. PMID: 23070608; PMCID: PMC3545523.
    Citations: 10     Fields:    Translation:AnimalsCells
  26. Marutani E, Kosugi S, Tokuda K, Khatri A, Nguyen R, Atochin DN, Kida K, Van Leyen K, Arai K, Ichinose F. A novel hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonist prevents ischemic neuronal death. J Biol Chem. 2012 Sep 14; 287(38):32124-35. PMID: 22815476; PMCID: PMC3442543.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  27. Yu Z, Xu J, Liu N, Wang Y, Li X, Pallast S, van Leyen K, Wang X. Mitochondrial distribution of neuroglobin and its response to oxygen-glucose deprivation in primary-cultured mouse cortical neurons. Neuroscience. 2012 Aug 30; 218:235-42. PMID: 22659017; PMCID: PMC3394186.
    Citations: 15     Fields:    Translation:AnimalsCells
  28. van Leyen K, Klötzsch C, Harrer JU. Brain tumor imaging with transcranial sonography: state of the art and review of the literature. Ultraschall Med. 2011 Dec; 32(6):572-81. PMID: 22033868.
    Citations: 2     Fields:    Translation:Humans
  29. Lok J, Leung W, Zhao S, Pallast S, van Leyen K, Guo S, Wang X, Yalcin A, Lo EH. ?-glutamylcysteine ethyl ester protects cerebral endothelial cells during injury and decreases blood-brain barrier permeability after experimental brain trauma. J Neurochem. 2011 Jul; 118(2):248-55. PMID: 21534958; PMCID: PMC3285992.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  30. Kan MC, Oruganty-Das A, Cooper-Morgan A, Jin G, Swanger SA, Bassell GJ, Florman H, van Leyen K, Richter JD. CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion. Mol Cell Biol. 2010 Dec; 30(24):5658-71. PMID: 20937770; PMCID: PMC3004280.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  31. Moore K, Lovercamp K, Feng D, Antelman J, Sutovsky M, Manandhar G, van Leyen K, Safranski T, Sutovsky P. Altered epididymal sperm maturation and cytoplasmic droplet migration in subfertile male Alox15 mice. Cell Tissue Res. 2010 Jun; 340(3):569-81. PMID: 20449608.
    Citations: 3     Fields:    Translation:AnimalsCells
  32. Pallast S, Arai K, Pekcec A, Yigitkanli K, Yu Z, Wang X, Lo EH, van Leyen K. Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1157-67. PMID: 20068575; PMCID: PMC2915762.
    Citations: 26     Fields:    Translation:AnimalsCells
  33. Tejima E, Guo S, Murata Y, Arai K, Lok J, van Leyen K, Rosell A, Wang X, Lo EH. Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1. J Neurotrauma. 2009 Nov; 26(11):1935-41. PMID: 19469687; PMCID: PMC2822804.
    Citations: 35     Fields:    Translation:AnimalsCells
  34. Lee BJ, Egi Y, van Leyen K, Lo EH, Arai K. Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro. Brain Res. 2010 Jan 11; 1307:22-7. PMID: 19840779; PMCID: PMC2797401.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  35. Pallast S, Arai K, Wang X, Lo EH, van Leyen K. 12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress. J Neurochem. 2009 Nov; 111(3):882-9. PMID: 19737346; PMCID: PMC2773137.
    Citations: 33     Fields:    Translation:AnimalsCells
  36. Hotokezaka Y, van Leyen K, Lo EH, Beatrix B, Katayama I, Jin G, Nakamura T. alphaNAC depletion as an initiator of ER stress-induced apoptosis in hypoxia. Cell Death Differ. 2009 Nov; 16(11):1505-14. PMID: 19609276.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  37. Gautschi OP, van Leyen K, Cadosch D, Hildebrandt G, Fournier JY. [Fluorescence guided resection of malignant brain tumors - breakthrough in the surgery of brain tumors]. Praxis (Bern 1994). 2009 Jun 10; 98(12):643-7. PMID: 19513974.
    Citations:    Fields:    Translation:Humans
  38. Foerch C, Arai K, Van Cott EM, van Leyen K, Lo EH. Rapid reversal of anticoagulation reduces hemorrhage volume in a mouse model of warfarin-associated intracerebral hemorrhage. J Cereb Blood Flow Metab. 2009 May; 29(5):1015-21. PMID: 19319147; PMCID: PMC3691988.
    Citations: 13     Fields:    Translation:HumansAnimals
  39. Foerch C, Arai K, Jin G, Park KP, Pallast S, van Leyen K, Lo EH. Experimental model of warfarin-associated intracerebral hemorrhage. Stroke. 2008 Dec; 39(12):3397-404. PMID: 18772448; PMCID: PMC3712841.
    Citations: 39     Fields:    Translation:Animals
  40. Jin G, Arai K, Murata Y, Wang S, Stins MF, Lo EH, van Leyen K. Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia. Stroke. 2008 Sep; 39(9):2538-43. PMID: 18635843; PMCID: PMC2754072.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  41. van Leyen K, Arai K, Jin G, Kenyon V, Gerstner B, Rosenberg PA, Holman TR, Lo EH. Novel lipoxygenase inhibitors as neuroprotective reagents. J Neurosci Res. 2008 Mar; 86(4):904-9. PMID: 17960827; PMCID: PMC2759176.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  42. Lok J, Gupta P, Guo S, Kim WJ, Whalen MJ, van Leyen K, Lo EH. Cell-cell signaling in the neurovascular unit. Neurochem Res. 2007 Dec; 32(12):2032-45. PMID: 17457674.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  43. van Leyen K, Kim HY, Lee SR, Jin G, Arai K, Lo EH. Baicalein and 12/15-lipoxygenase in the ischemic brain. Stroke. 2006 Dec; 37(12):3014-8. PMID: 17053180.
    Citations: 59     Fields:    Translation:AnimalsCells
  44. Tejima E, Zhao BQ, Tsuji K, Rosell A, van Leyen K, Gonzalez RG, Montaner J, Wang X, Lo EH. Astrocytic induction of matrix metalloproteinase-9 and edema in brain hemorrhage. J Cereb Blood Flow Metab. 2007 Mar; 27(3):460-8. PMID: 16788715.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  45. Fischer KA, Van Leyen K, Lovercamp KW, Manandhar G, Sutovsky M, Feng D, Safranski T, Sutovsky P. 15-Lipoxygenase is a component of the mammalian sperm cytoplasmic droplet. Reproduction. 2005 Aug; 130(2):213-22. PMID: 16049159.
    Citations: 9     Fields:    Translation:AnimalsCells
  46. Black VH, Sanjay A, van Leyen K, Lauring B, Kreibich G. Cholesterol and steroid synthesizing smooth endoplasmic reticulum of adrenocortical cells contains high levels of proteins associated with the translocation channel. Endocrinology. 2005 Oct; 146(10):4234-49. PMID: 15947003.
    Citations: 6     Fields:    Translation:AnimalsCells
  47. van Leyen K, Siddiq A, Ratan RR, Lo EH. Proteasome inhibition protects HT22 neuronal cells from oxidative glutamate toxicity. J Neurochem. 2005 Feb; 92(4):824-30. PMID: 15686484; PMCID: PMC2570092.
    Citations: 25     Fields:    Translation:AnimalsCells
  48. Arai K, Lee SR, van Leyen K, Kurose H, Lo EH. Involvement of ERK MAP kinase in endoplasmic reticulum stress in SH-SY5Y human neuroblastoma cells. J Neurochem. 2004 Apr; 89(1):232-9. PMID: 15030407.
    Citations: 17     Fields:    Translation:HumansCells
  49. Sutovsky P, Van Leyen K, McCauley T, Day BN, Sutovsky M. Degradation of paternal mitochondria after fertilization: implications for heteroplasmy, assisted reproductive technologies and mtDNA inheritance. Reprod Biomed Online. 2004 Jan; 8(1):24-33. PMID: 14759284.
    Citations: 15     Fields:    Translation:HumansCells
  50. Antipenko A, Himanen JP, van Leyen K, Nardi-Dei V, Lesniak J, Barton WA, Rajashankar KR, Lu M, Hoemme C, Püschel AW, Nikolov DB. Structure of the semaphorin-3A receptor binding module. Neuron. 2003 Aug 14; 39(4):589-98. PMID: 12925274.
    Citations: 51     Fields:    Translation:AnimalsCells
  51. Black VH, Sanjay A, van Leyen K, Möeller I, Lauring B, Kreibich G. Cholesterol and steroid synthesizing smooth endoplasmic reticulum of adrenocortical cells contains high levels of translocation apparatus proteins. Endocr Res. 2002 Nov; 28(4):425-30. PMID: 12530645.
    Citations:    Fields:    Translation:AnimalsCells
  52. Hotokezaka Y, Tobben U, Hotokezaka H, Van Leyen K, Beatrix B, Smith DH, Nakamura T, Wiedmann M. Interaction of the eukaryotic elongation factor 1A with newly synthesized polypeptides. J Biol Chem. 2002 May 24; 277(21):18545-51. PMID: 11893745.
    Citations: 28     Fields:    Translation:AnimalsCells
  53. Grüllich C, Duvoisin RM, Wiedmann M, van Leyen K. Inhibition of 15-lipoxygenase leads to delayed organelle degradation in the reticulocyte. FEBS Lett. 2001 Jan 26; 489(1):51-4. PMID: 11231012.
    Citations: 27     Fields:    Translation:AnimalsCells
  54. Pierce JP, van Leyen K, McCarthy JB. Translocation machinery for synthesis of integral membrane and secretory proteins in dendritic spines. Nat Neurosci. 2000 Apr; 3(4):311-3. PMID: 10725917.
    Citations: 20     Fields:    Translation:AnimalsCells
  55. Rush JS, van Leyen K, Ouerfelli O, Wolucka B, Waechter CJ. Transbilayer movement of Glc-P-dolichol and its function as a glucosyl donor: protein-mediated transport of a water-soluble analog into sealed ER vesicles from pig brain. Glycobiology. 1998 Dec; 8(12):1195-205. PMID: 9858641.
    Citations: 13     Fields:    Translation:AnimalsCells
  56. van Leyen K. Pictures in cell biology. Un-LOXing the door to organelle degradation. Trends Cell Biol. 1998 Nov; 8(11):436. PMID: 9854309.
    Citations: 2     Fields:    Translation:AnimalsCells
  57. van Leyen K, Duvoisin RM, Engelhardt H, Wiedmann M. A function for lipoxygenase in programmed organelle degradation. Nature. 1998 Sep 24; 395(6700):392-5. PMID: 9759730.
    Citations: 58     Fields:    Translation:AnimalsCells
  58. Suhm N, Dams J, van Leyen K, Lorenz A, Bendl R. Limitations for three-dimensional ultrasound imaging through a bore-hole trepanation. Ultrasound Med Biol. 1998 Jun; 24(5):663-71. PMID: 9695269.
    Citations:    Fields:    Translation:Humans
  59. van Leyen K, Widemann M, Wieland F. Glycotripeptides are released by yeast but not by mammalian microsomes. FEBS Lett. 1994 Nov 28; 355(2):147-50. PMID: 7982488.
    Citations: 2     Fields:    Translation:AnimalsCells
  60. van Leyen K, Wieland F. Complete Golgi passage of glycotripeptides generated in the endoplasmic reticulum of mammalian cells. FEBS Lett. 1994 Sep 26; 352(2):211-5. PMID: 7925975.
    Citations: 1     Fields:    Translation:AnimalsCells
  61. Jaenicke L, van Leyen K, Siegmund HU. Dolichyl phosphate-dependent glycosyltransferases utilize truncated cofactors. Biol Chem Hoppe Seyler. 1991 Nov; 372(11):1021-6. PMID: 1724374.
    Citations: 1     Fields:    Translation:AnimalsCells
  62. Sanker P, Richard KE, Weigl HC, Klug N, van Leyen K. Transcranial Doppler sonography and intracranial pressure monitoring in children and juveniles with acute brain injuries or hydrocephalus. Childs Nerv Syst. 1991 Nov; 7(7):391-3. PMID: 1794119.
    Citations: 3     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.