Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Myles A. Brown, M.D.

Title
Institution
Department
Address
Phone
Fax

Mentoring
completed student projects
Unraveling the epigenetic and estrogen receptor cistromic alterations in breast cancer
Full Time, 06/01/11 - 05/31/12
Differential estrogen receptor signaling in normal mammary epithelial cells, primary breast cancers and metastases
Full Time, 06/13/11 - 05/01/15

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HG008728 (BROWN, MYLES A) Sep 1, 2015 - Aug 31, 2019
    NIH
    Large-Scale In Vivo Functional Characterization of the Human Cistrome
    Role: Principal Investigator
  2. R01CA193910 (FREEDMAN, MATTHEW L) Mar 1, 2015 - Feb 29, 2020
    NIH
    Defining the epigenetic landscape in human prostate cancer
    Role: Principal Investigator
  3. P50CA168504 (WINER, ERIC P) Sep 17, 2013 - May 31, 2024
    NIH
    Dana-Farber/Harvard Cancer Center SPORE in Breast Cancer
    Role: Co-Principal Investigator
  4. P01CA163227 (BALK, STEVEN P) May 24, 2013 - Jan 31, 2024
    NIH
    Androgen Receptor Action in Castration Resistant Prostate Cancer
    Role: Co-Principal Investigator
  5. R01DK074967 (BROWN, MYLES A) May 15, 2007 - Apr 30, 2014
    NIH
    Comprehensive Analysis of Estrogen Receptor Genomic Action
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ni J, Kabraji S, Xie S, Wang Y, Pan P, He X, Liu Z, Leone JP, Long HW, Brown MA, Winer EP, Dillon DAR, Lin NU, Zhao JJ. p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases. Nat Commun. 2022 03 18; 13(1):1473. PMID: 35304445; PMCID: PMC8933392.
    Citations: 3     Fields:    Translation:Humans
  2. Fu X, Pereira R, De Angelis C, Veeraraghavan J, Nanda S, Qin L, Cataldo ML, Sethunath V, Mehravaran S, Gutierrez C, Chamness GC, Feng Q, O'Malley BW, Selenica P, Weigelt B, Reis-Filho JS, Cohen O, Wagle N, Nardone A, Jeselsohn R, Brown M, Rimawi MF, Osborne CK, Schiff R. FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26823-26834. PMID: 31826955; PMCID: PMC6936436.
    Citations: 47     Fields:    
  3. Jiang P, Gu S, Pan D, Fu J, Sahu A, Hu X, Li Z, Traugh N, Bu X, Li B, Liu J, Freeman GJ, Brown MA, Wucherpfennig KW, Liu XS. Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response. Nat Med. 2018 10; 24(10):1550-1558. PMID: 30127393; PMCID: PMC6487502.
    Citations: 1397     Fields:    Translation:HumansAnimalsCells
  4. Brown M. Enhancing Therapy: It's about Time. Cell. 2018 08 09; 174(4):771-772. PMID: 30096305.
    Citations:    Fields:    Translation:Humans
  5. Fei T, Chen Y, Xiao T, Li W, Cato L, Zhang P, Cotter MB, Bowden M, Lis RT, Zhao SG, Wu Q, Feng FY, Loda M, He HH, Liu XS, Brown M. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):E5207-E5215. PMID: 28611215; PMCID: PMC5495225.
    Citations: 144     Fields:    Translation:HumansCells
  6. Jeselsohn R, Cornwell M, Pun M, Buchwalter G, Nguyen M, Bango C, Huang Y, Kuang Y, Paweletz C, Fu X, Nardone A, De Angelis C, Detre S, Dodson A, Mohammed H, Carroll JS, Bowden M, Rao P, Long HW, Li F, Dowsett M, Schiff R, Brown M. Embryonic transcription factor SOX9 drives breast cancer endocrine resistance. Proc Natl Acad Sci U S A. 2017 05 30; 114(22):E4482-E4491. PMID: 28507152; PMCID: PMC5465894.
    Citations: 43     Fields:    Translation:HumansCells
  7. Jeselsohn R, Barry WT, Migliaccio I, Biagioni C, Zhao J, De Tribolet-Hardy J, Guarducci C, Bonechi M, Laing N, Winer EP, Brown M, Leo AD, Malorni L. TransCONFIRM: Identification of a Genetic Signature of Response to Fulvestrant in Advanced Hormone Receptor-Positive Breast Cancer. Clin Cancer Res. 2016 Dec 01; 22(23):5755-5764. PMID: 27185372; PMCID: PMC5124409.
    Citations: 15     Fields:    Translation:HumansCellsCTClinical Trials
  8. Yang M, Xie W, Mostaghel E, Nakabayashi M, Werner L, Sun T, Pomerantz M, Freedman M, Ross R, Regan M, Sharifi N, Figg WD, Balk S, Brown M, Taplin ME, Oh WK, Lee GS, Kantoff PW. SLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer. J Clin Oncol. 2011 Jun 20; 29(18):2565-73. PMID: 21606417.
    Citations: 81     Fields:    Translation:Humans
  9. Meyer CA, He HH, Brown M, Liu XS. BINOCh: binding inference from nucleosome occupancy changes. Bioinformatics. 2011 Jul 01; 27(13):1867-8. PMID: 21551136.
    Citations: 13     Fields:    Translation:HumansCells
  10. Flavin RJ, Cook J, Fiorentino M, Bailey D, Brown M, Loda MF. ß-Catenin is a useful adjunct immunohistochemical marker for the diagnosis of pulmonary lymphangioleiomyomatosis. Am J Clin Pathol. 2011 May; 135(5):776-82. PMID: 21502434.
    Citations: 12     Fields:    Translation:HumansCells
  11. Baba A, Ohtake F, Okuno Y, Yokota K, Okada M, Imai Y, Ni M, Meyer CA, Igarashi K, Kanno J, Brown M, Kato S. PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B. Nat Cell Biol. 2011 Jun; 13(6):668-75. PMID: 21532585.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  12. Sérandour AA, Avner S, Percevault F, Demay F, Bizot M, Lucchetti-Miganeh C, Barloy-Hubler F, Brown M, Lupien M, Métivier R, Salbert G, Eeckhoute J. Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers. Genome Res. 2011 Apr; 21(4):555-65. PMID: 21233399.
    Citations: 126     Fields:    Translation:HumansAnimalsCells
  13. Frigo DE, Howe MK, Wittmann BM, Brunner AM, Cushman I, Wang Q, Brown M, Means AR, McDonnell DP. CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells. Cancer Res. 2011 Jan 15; 71(2):528-37. PMID: 21098087; PMCID: PMC3074523.
    Citations: 73     Fields:    Translation:HumansCells
  14. Verzi MP, Shin H, He HH, Sulahian R, Meyer CA, Montgomery RK, Fleet JC, Brown M, Liu XS, Shivdasani RA. Differentiation-specific histone modifications reveal dynamic chromatin interactions and partners for the intestinal transcription factor CDX2. Dev Cell. 2010 Nov 16; 19(5):713-26. PMID: 21074721.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  15. Madak-Erdogan Z, Lupien M, Stossi F, Brown M, Katzenellenbogen BS. Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs. Mol Cell Biol. 2011 Jan; 31(1):226-36. PMID: 20956553.
    Citations: 65     Fields:    Translation:HumansCells
  16. Lupien M, Meyer CA, Bailey ST, Eeckhoute J, Cook J, Westerling T, Zhang X, Carroll JS, Rhodes DR, Liu XS, Brown M. Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance. Genes Dev. 2010 Oct 01; 24(19):2219-27. PMID: 20889718; PMCID: PMC2947773.
    Citations: 100     Fields:    Translation:HumansCells
  17. Verzi MP, Hatzis P, Sulahian R, Philips J, Schuijers J, Shin H, Freed E, Lynch JP, Dang DT, Brown M, Clevers H, Liu XS, Shivdasani RA. TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15157-62. PMID: 20696899.
    Citations: 44     Fields:    Translation:HumansCells
  18. Ahmadiyeh N, Pomerantz MM, Grisanzio C, Herman P, Jia L, Almendro V, He HH, Brown M, Liu XS, Davis M, Caswell JL, Beckwith CA, Hills A, Macconaill L, Coetzee GA, Regan MM, Freedman ML. 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9742-6. PMID: 20453196; PMCID: PMC2906844.
    Citations: 204     Fields:    Translation:HumansCells
  19. Torres-Arzayus MI, Zhao J, Bronson R, Brown M. Estrogen-dependent and estrogen-independent mechanisms contribute to AIB1-mediated tumor formation. Cancer Res. 2010 May 15; 70(10):4102-11. PMID: 20442283.
    Citations: 26     Fields:    Translation:AnimalsCells
  20. Badve S, Collins NR, Bhat-Nakshatri P, Turbin D, Leung S, Thorat M, Dunn SE, Geistlinger TR, Carroll JS, Brown M, Bose S, Teitell MA, Nakshatri H. Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications. Am J Pathol. 2010 May; 176(5):2139-49. PMID: 20228224; PMCID: PMC2861080.
    Citations: 25     Fields:    Translation:HumansCells
  21. He HH, Meyer CA, Shin H, Bailey ST, Wei G, Wang Q, Zhang Y, Xu K, Ni M, Lupien M, Mieczkowski P, Lieb JD, Zhao K, Brown M, Liu XS. Nucleosome dynamics define transcriptional enhancers. Nat Genet. 2010 Apr; 42(4):343-7. PMID: 20208536; PMCID: PMC2932437.
    Citations: 287     Fields:    Translation:HumansCells
  22. Wolfer A, Wittner BS, Irimia D, Flavin RJ, Lupien M, Gunawardane RN, Meyer CA, Lightcap ES, Tamayo P, Mesirov JP, Liu XS, Shioda T, Toner M, Loda M, Brown M, Brugge JS, Ramaswamy S. MYC regulation of a "poor-prognosis" metastatic cancer cell state. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3698-703. PMID: 20133671.
    Citations: 104     Fields:    Translation:Humans
  23. Wade HE, Kobayashi S, Eaton ML, Jansen MS, Lobenhofer EK, Lupien M, Geistlinger TR, Zhu W, Nevins JR, Brown M, Otteson DC, McDonnell DP. Multimodal regulation of E2F1 gene expression by progestins. Mol Cell Biol. 2010 Apr; 30(8):1866-77. PMID: 20123965.
    Citations: 16     Fields:    Translation:HumansCells
  24. Zhang Q, Gu J, Li L, Liu J, Luo B, Cheung HW, Boehm JS, Ni M, Geisen C, Root DE, Polyak K, Brown M, Richardson AL, Hahn WC, Kaelin WG, Bommi-Reddy A. Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. Cancer Cell. 2009 Nov 06; 16(5):413-24. PMID: 19878873; PMCID: PMC2788761.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  25. Boros J, Donaldson IJ, O'Donnell A, Odrowaz ZA, Zeef L, Lupien M, Meyer CA, Liu XS, Brown M, Sharrocks AD. Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery. Genome Res. 2009 Nov; 19(11):1963-73. PMID: 19687146.
    Citations: 79     Fields:    Translation:HumansCells
  26. Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, Chen Z, Beroukhim R, Wang H, Lupien M, Wu T, Regan MM, Meyer CA, Carroll JS, Manrai AK, Jänne OA, Balk SP, Mehra R, Han B, Chinnaiyan AM, Rubin MA, True L, Fiorentino M, Fiore C, Loda M, Kantoff PW, Liu XS, Brown M. Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell. 2009 Jul 23; 138(2):245-56. PMID: 19632176.
    Citations: 492     Fields:    Translation:HumansCells
  27. Bhat-Nakshatri P, Wang G, Collins NR, Thomson MJ, Geistlinger TR, Carroll JS, Brown M, Hammond S, Srour EF, Liu Y, Nakshatri H. Estradiol-regulated microRNAs control estradiol response in breast cancer cells. Nucleic Acids Res. 2009 Aug; 37(14):4850-61. PMID: 19528081.
    Citations: 160     Fields:    Translation:HumansCells
  28. Nucera C, Eeckhoute J, Finn S, Carroll JS, Ligon AH, Priolo C, Fadda G, Toner M, Sheils O, Attard M, Pontecorvi A, Nose V, Loda M, Brown M. FOXA1 is a potential oncogene in anaplastic thyroid carcinoma. Clin Cancer Res. 2009 Jun 01; 15(11):3680-9. PMID: 19470727.
    Citations: 35     Fields:    Translation:Humans
  29. Frigo DE, Sherk AB, Wittmann BM, Norris JD, Wang Q, Joseph JD, Toner AP, Brown M, McDonnell DP. Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro. Mol Endocrinol. 2009 Sep; 23(9):1385-96. PMID: 19460858.
    Citations: 40     Fields:    Translation:HumansCells
  30. Lupien M, Brown M. Cistromics of hormone-dependent cancer. Endocr Relat Cancer. 2009 Jun; 16(2):381-9. PMID: 19369485.
    Citations: 50     Fields:    Translation:HumansCells
  31. Lupien M, Eeckhoute J, Meyer CA, Krum SA, Rhodes DR, Liu XS, Brown M. Coactivator function defines the active estrogen receptor alpha cistrome. Mol Cell Biol. 2009 Jun; 29(12):3413-23. PMID: 19364822.
    Citations: 44     Fields:    Translation:HumansCells
  32. Sun T, Wang Q, Balk S, Brown M, Lee GS, Kantoff P. The role of microRNA-221 and microRNA-222 in androgen-independent prostate cancer cell lines. Cancer Res. 2009 Apr 15; 69(8):3356-63. PMID: 19351832.
    Citations: 110     Fields:    Translation:HumansCells
  33. Nwachukwu JC, Mita P, Ruoff R, Ha S, Wang Q, Huang SJ, Taneja SS, Brown M, Gerald WL, Garabedian MJ, Logan SK. Genome-wide impact of androgen receptor trapped clone-27 loss on androgen-regulated transcription in prostate cancer cells. Cancer Res. 2009 Apr 01; 69(7):3140-7. PMID: 19318562.
    Citations: 14     Fields:    Translation:HumansCells
  34. Xia X, Lemieux ME, Li W, Carroll JS, Brown M, Liu XS, Kung AL. Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4260-5. PMID: 19255431.
    Citations: 198     Fields:    Translation:HumansCells
  35. Eeckhoute J, Lupien M, Meyer CA, Verzi MP, Shivdasani RA, Liu XS, Brown M. Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers. Genome Res. 2009 Mar; 19(3):372-80. PMID: 19129543.
    Citations: 67     Fields:    Translation:HumansCells
  36. Eeckhoute J, Lupien M, Brown M. Combining chromatin immunoprecipitation and oligonucleotide tiling arrays (ChIP-Chip) for functional genomic studies. Methods Mol Biol. 2009; 556:155-64. PMID: 19488877.
    Citations: 3     Fields:    Translation:Humans
  37. Hurtado A, Holmes KA, Geistlinger TR, Hutcheson IR, Nicholson RI, Brown M, Jiang J, Howat WJ, Ali S, Carroll JS. Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen. Nature. 2008 Dec 04; 456(7222):663-6. PMID: 19005469.
    Citations: 140     Fields:    Translation:HumansCells
  38. Bhat-Nakshatri P, Wang G, Appaiah H, Luktuke N, Carroll JS, Geistlinger TR, Brown M, Badve S, Liu Y, Nakshatri H. AKT alters genome-wide estrogen receptor alpha binding and impacts estrogen signaling in breast cancer. Mol Cell Biol. 2008 Dec; 28(24):7487-503. PMID: 18838536.
    Citations: 54     Fields:    Translation:HumansCells
  39. Krum SA, Miranda-Carboni GA, Lupien M, Eeckhoute J, Carroll JS, Brown M. Unique ERalpha cistromes control cell type-specific gene regulation. Mol Endocrinol. 2008 Nov; 22(11):2393-406. PMID: 18818283; PMCID: PMC2582540.
    Citations: 77     Fields:    Translation:HumansCells
  40. Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W, Liu XS. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008; 9(9):R137. PMID: 18798982.
    Citations: 7229     Fields:    Translation:HumansCells
  41. Bao BY, Chuang BF, Wang Q, Sartor O, Balk SP, Brown M, Kantoff PW, Lee GS. Androgen receptor mediates the expression of UDP-glucuronosyltransferase 2 B15 and B17 genes. Prostate. 2008 Jun 01; 68(8):839-48. PMID: 18302198.
    Citations: 32     Fields:    Translation:HumansCells
  42. Setlur SR, Mertz KD, Hoshida Y, Demichelis F, Lupien M, Perner S, Sboner A, Pawitan Y, Andrén O, Johnson LA, Tang J, Adami HO, Calza S, Chinnaiyan AM, Rhodes D, Tomlins S, Fall K, Mucci LA, Kantoff PW, Stampfer MJ, Andersson SO, Varenhorst E, Johansson JE, Brown M, Golub TR, Rubin MA. Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer. J Natl Cancer Inst. 2008 Jun 04; 100(11):815-25. PMID: 18505969.
    Citations: 165     Fields:    Translation:HumansCells
  43. Yang XH, Richardson AL, Torres-Arzayus MI, Zhou P, Sharma C, Kazarov AR, Andzelm MM, Strominger JL, Brown M, Hemler ME. CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization. Cancer Res. 2008 May 01; 68(9):3204-13. PMID: 18451146.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  44. Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Li W, Carroll JS, Liu XS, Brown M. FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell. 2008 Mar 21; 132(6):958-70. PMID: 18358809.
    Citations: 545     Fields:    Translation:HumansCells
  45. Leleu X, Eeckhoute J, Jia X, Roccaro AM, Moreau AS, Farag M, Sacco A, Ngo HT, Runnels J, Melhem MR, Burwick N, Azab A, Azab F, Hunter Z, Hatjiharissi E, Carrasco DR, Treon SP, Witzig TE, Hideshima T, Brown M, Anderson KC, Ghobrial IM. Targeting NF-kappaB in Waldenstrom macroglobulinemia. Blood. 2008 May 15; 111(10):5068-77. PMID: 18334673; PMCID: PMC2384134.
    Citations: 32     Fields:    Translation:HumansCells
  46. Krum SA, Brown M. Unraveling estrogen action in osteoporosis. Cell Cycle. 2008 May 15; 7(10):1348-52. PMID: 18418063.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  47. Krum SA, Miranda-Carboni GA, Hauschka PV, Carroll JS, Lane TF, Freedman LP, Brown M. Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival. EMBO J. 2008 Feb 06; 27(3):535-45. PMID: 18219273.
    Citations: 125     Fields:    Translation:HumansAnimalsCells
  48. Li W, Carroll JS, Brown M, Liu xS. xMAN: extreme MApping of OligoNucleotides. BMC Genomics. 2008; 9 Suppl 1:S20. PMID: 18366610.
    Citations: 12     Fields:    
  49. Frietze S, Lupien M, Silver PA, Brown M. CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1. Cancer Res. 2008 Jan 01; 68(1):301-6. PMID: 18172323.
    Citations: 91     Fields:    Translation:HumansCells
  50. Wang Q, Li W, Liu XS, Carroll JS, Jänne OA, Keeton EK, Chinnaiyan AM, Pienta KJ, Brown M. A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol Cell. 2007 Aug 03; 27(3):380-92. PMID: 17679089; PMCID: PMC3947890.
    Citations: 347     Fields:    Translation:HumansCells
  51. Eeckhoute J, Keeton EK, Lupien M, Krum SA, Carroll JS, Brown M. Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer. Cancer Res. 2007 Jul 01; 67(13):6477-83. PMID: 17616709.
    Citations: 186     Fields:    Translation:HumansCells
  52. Torres-Arzayus MI, Yuan J, DellaGatta JL, Lane H, Kung AL, Brown M. Targeting the AIB1 oncogene through mammalian target of rapamycin inhibition in the mammary gland. Cancer Res. 2006 Dec 01; 66(23):11381-8. PMID: 17145884.
    Citations: 31     Fields:    Translation:AnimalsCells
  53. Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M. Genome-wide analysis of estrogen receptor binding sites. Nat Genet. 2006 Nov; 38(11):1289-97. PMID: 17013392.
    Citations: 748     Fields:    Translation:HumansCells
  54. Eeckhoute J, Carroll JS, Geistlinger TR, Torres-Arzayus MI, Brown M. A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer. Genes Dev. 2006 Sep 15; 20(18):2513-26. PMID: 16980581; PMCID: PMC1578675.
    Citations: 140     Fields:    Translation:HumansCells
  55. Johnson WE, Li W, Meyer CA, Gottardo R, Carroll JS, Brown M, Liu XS. Model-based analysis of tiling-arrays for ChIP-chip. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12457-62. PMID: 16895995; PMCID: PMC1567901.
    Citations: 266     Fields:    Translation:Humans
  56. Carroll DK, Carroll JS, Leong CO, Cheng F, Brown M, Mills AA, Brugge JS, Ellisen LW. p63 regulates an adhesion programme and cell survival in epithelial cells. Nat Cell Biol. 2006 Jun; 8(6):551-61. PMID: 16715076.
    Citations: 215     Fields:    Translation:HumansCells
  57. Richardson AL, Wang ZC, De Nicolo A, Lu X, Brown M, Miron A, Liao X, Iglehart JD, Livingston DM, Ganesan S. X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell. 2006 Feb; 9(2):121-32. PMID: 16473279.
    Citations: 440     Fields:    Translation:HumansCells
  58. Come SE, Buzdar AU, Ingle JN, Arteaga CL, Brown M, Dowsett M, Hilsenbeck SG, Kumar R, Johnston SR, Lee AV, Paik S, Pritchard KI, Winer EP, Hart C. Proceedings of the Fifth International Conference on Recent Advances and Future Directions in Endocrine Therapy for Breast Cancer: conference summary statement. Clin Cancer Res. 2006 Feb 01; 12(3 Pt 2):997s-1000s. PMID: 16467115.
    Citations: 2     Fields:    Translation:Humans
  59. Carroll JS, Brown M. Estrogen receptor target gene: an evolving concept. Mol Endocrinol. 2006 Aug; 20(8):1707-14. PMID: 16396959.
    Citations: 122     Fields:    Translation:HumansAnimalsCells
  60. Wang Q, Carroll JS, Brown M. Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking. Mol Cell. 2005 Sep 02; 19(5):631-42. PMID: 16137620.
    Citations: 235     Fields:    Translation:HumansCells
  61. Carroll JS, Liu XS, Brodsky AS, Li W, Meyer CA, Szary AJ, Eeckhoute J, Shao W, Hestermann EV, Geistlinger TR, Fox EA, Silver PA, Brown M. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell. 2005 Jul 15; 122(1):33-43. PMID: 16009131.
    Citations: 708     Fields:    Translation:HumansAnimalsCells
  62. Febbo PG, Lowenberg M, Thorner AR, Brown M, Loda M, Golub TR. Androgen mediated regulation and functional implications of fkbp51 expression in prostate cancer. J Urol. 2005 May; 173(5):1772-7. PMID: 15821585.
    Citations: 41     Fields:    Translation:Humans
  63. Keeton EK, Brown M. Cell cycle progression stimulated by tamoxifen-bound estrogen receptor-alpha and promoter-specific effects in breast cancer cells deficient in N-CoR and SMRT. Mol Endocrinol. 2005 Jun; 19(6):1543-54. PMID: 15802375.
    Citations: 48     Fields:    Translation:HumansCells
  64. Torres-Arzayus MI, Font de Mora J, Yuan J, Vazquez F, Bronson R, Rue M, Sellers WR, Brown M. High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene. Cancer Cell. 2004 Sep; 6(3):263-74. PMID: 15380517.
    Citations: 182     Fields:    Translation:AnimalsCells
  65. Shao W, Keeton EK, McDonnell DP, Brown M. Coactivator AIB1 links estrogen receptor transcriptional activity and stability. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11599-604. PMID: 15289619; PMCID: PMC511007.
    Citations: 51     Fields:    Translation:HumansCells
  66. Come SE, Buzdar AU, Arteaga CL, Bissell MJ, Brown MA, Ellis MJ, Goss PE, Green JE, Ingle JN, Lee AV, Medina D, Nicholson RI, Santen RJ, Schiff R, Hart CS. Proceedings of the Third International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: conference summary statement. Clin Cancer Res. 2004 Jan 01; 10(1 Pt 2):327S-330S. PMID: 14734487.
    Citations: 1     Fields:    Translation:HumansCells
  67. Shao W, Brown M. Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy. Breast Cancer Res. 2004; 6(1):39-52. PMID: 14680484; PMCID: PMC314456.
    Citations: 49     Fields:    Translation:HumansCells
  68. Hestermann EV, Brown M. Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor. Mol Cell Biol. 2003 Nov; 23(21):7920-5. PMID: 14560034.
    Citations: 59     Fields:    Translation:HumansCells
  69. Keeton EK, Brown M. Coregulator expression and breast cancer: improving the predictive power of estrogen receptor alpha. Clin Cancer Res. 2003 Apr; 9(4):1229-30. PMID: 12684386.
    Citations: 3     Fields:    Translation:Humans
  70. Carroll PR, Kantoff PW, Balk SP, Brown MA, D'amico AV, George DJ, Grossfeld GD, Johnson CS, Kelly WK, Klotz L, Lee WR, Lubeck DP, Mcleod DG, Oh WK, Pollack A, Sartor O, Smith MR, Hart C. Overview consensus statement. Newer approaches to androgen deprivation therapy in prostate cancer. Urology. 2002 Sep; 60(3 Suppl 1):1-6. PMID: 12231036.
    Citations: 8     Fields:    Translation:Humans
  71. Shao W, Halachmi S, Brown M. ERAP140, a conserved tissue-specific nuclear receptor coactivator. Mol Cell Biol. 2002 May; 22(10):3358-72. PMID: 11971969.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  72. Shang Y, Brown M. Molecular determinants for the tissue specificity of SERMs. Science. 2002 Mar 29; 295(5564):2465-8. PMID: 11923541.
    Citations: 317     Fields:    Translation:HumansCells
  73. Shang Y, Myers M, Brown M. Formation of the androgen receptor transcription complex. Mol Cell. 2002 Mar; 9(3):601-10. PMID: 11931767.
    Citations: 256     Fields:    Translation:HumansCells
  74. Haiman CA, Brown M, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Kantoff PW, Hunter DJ. The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study. Cancer Res. 2002 Feb 15; 62(4):1045-9. PMID: 11861380.
    Citations: 16     Fields:    Translation:HumansCells
  75. Haiman CA, Hankinson SE, Spiegelman D, Brown M, Hunter DJ. No association between a single nucleotide polymorphism in CYP19 and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2002 Feb; 11(2):215-6. PMID: 11867511.
    Citations: 15     Fields:    Translation:Humans
  76. DiRenzo J, Signoretti S, Nakamura N, Rivera-Gonzalez R, Sellers W, Loda M, Brown M. Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line. Cancer Res. 2002 Jan 01; 62(1):89-98. PMID: 11782364.
    Citations: 50     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.