Profiles Header - Harvard Catalyst Profiles Header – Harvard Catalyst

Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Frank A.J.L. Scheer, PH.D.

Profile Picture

2005 - 2007
Pickwick Postdoctoral Fellowship, National Sleep Foundation
Young Investigator Neurology Section Award, American Academy of Sleep Medicine
Alliance Chronosleep Award, European Sleep Research Society
Finalist Helgi Kristbjarnarson's Award, European Sleep Research Society
Young Investigator Award, American Academy of Sleep
1st Place Clinical Research Young Investigator Award, National Sleep Foundation
Neal Miller Award, Academy of Behavioral Medicine Research
Young Investigator Award, Honorable Mention, Sleep Research Society
Nominated for the 2013-2014 Harold Amos Faculty Diversity Award, Harvard Medical School
Nominated for 2014-2015 A. Clifford Barger Excellence in Mentoring Award, Harvard Medical School

Dr. Frank A.J.L. Scheer is Associate Professor of Medicine at Harvard Medical School and the Director of the Medical Chronobiology Program at Brigham and Women’s Hospital.

Dr. Scheer is primarily interested in medical chronobiology, including the underlying physiological mechanisms and therapeutic strategies. His work focuses on circadian and behavioral influences (including the sleep/wake cycle) on cardiovascular, pulmonary, and metabolic regulation and disease. Furthermore, he is interested in fundamental properties of the human circadian timing system, including effects of light and melatonin.

Dr. Scheer received his PhD in Neuroscience at the Netherlands Institute for Brain Research in Amsterdam, The Netherlands, and his postdoctoral training in the laboratories of Drs. Charles A. Czeisler and Steven A. Shea.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL140574 (SCHEER, FRANK A) Sep 15, 2017 - May 31, 2022
    Role of Meal Timing in Efficacy of Bariatric Surgery in Obese Individuals
    Role: Principal Investigator
  2. R01DK105072 (SAXENA, RICHA) Jun 1, 2016 - May 31, 2021
    Impact of malatonin, food timing and receptor variant on type 2 diabetes risk
    Role: Co-Principal Investigator
  3. R01DK102696 (SCHEER, FRANK A) Aug 19, 2015 - May 31, 2020
    Melatonin and Receptor Gene Variant: Linking Circadian System and Type 2 Diabetes
    Role: Co-Principal Investigator
  4. R01HL118601 (SCHEER, FRANK A) Jun 1, 2014 - Mar 31, 2018
    Development of countermeasures against adverse metabolic effects of shift work
    Role: Principal Investigator
  5. R01DK099512 (SCHEER, FRANK A) May 15, 2014 - Apr 30, 2018
    Meal Time Effects on Metabolic Health.
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Qian J, Morris CJ, Caputo R, Garaulet M, Scheer FAJL. Ghrelin is impacted by the endogenous circadian system and by circadian misalignment in humans. Int J Obes (Lond). 2018 Sep 19. PMID: 30232416.
    View in: PubMed
  2. Wefers J, van Moorsel D, Hansen J, Connell NJ, Havekes B, Hoeks J, van Marken Lichtenbelt WD, Duez H, Phielix E, Kalsbeek A, Boekschoten MV, Hooiveld GJ, Hesselink MKC, Kersten S, Staels B, Scheer FAJL, Schrauwen P. Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):7789-7794. PMID: 29987027.
    View in: PubMed
  3. Qian J, Dalla Man C, Morris CJ, Cobelli C, Scheer FAJL. Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans. Diabetes Obes Metab. 2018 Oct; 20(10):2481-2485. PMID: 29862620.
    View in: PubMed
  4. Kolbe I, Carrasco-Benso MP, López-Mínguez J, Luján J, Scheer FAJL, Oster H, Garaulet M. Circadian period of luciferase expression shortens with age in human mature adipocytes from obese patients. FASEB J. 2018 Jul 02; fj201800441R. PMID: 29965796.
    View in: PubMed
  5. Li P, Yu L, Lim ASP, Buchman AS, Scheer FAJL, Shea SA, Schneider JA, Bennett DA, Hu K. Fractal regulation and incident Alzheimer's disease in elderly individuals. Alzheimers Dement. 2018 Sep; 14(9):1114-1125. PMID: 29733807.
    View in: PubMed
  6. Lopez-Minguez J, Dashti HS, Madrid-Valero JJ, Madrid JA, Saxena R, Scheer FA, Ordoñana JR, Garaulet M. Heritability of the timing of food intake. Clin Nutr. 2018 Mar 12. PMID: 29571565.
    View in: PubMed
  7. Chellappa SL, Morris CJ, Scheer FAJL. Daily circadian misalignment impairs human cognitive performance task-dependently. Sci Rep. 2018 Feb 14; 8(1):3041. PMID: 29445188.
    View in: PubMed
  8. Vetter C, Dashti HS, Lane JM, Anderson SG, Schernhammer ES, Rutter MK, Saxena R, Scheer FAJL. Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank. Diabetes Care. 2018 04; 41(4):762-769. PMID: 29440150.
    View in: PubMed
  9. Vera B, Dashti HS, Gómez-Abellán P, Hernández-Martínez AM, Esteban A, Scheer FAJL, Saxena R, Garaulet M. Modifiable lifestyle behaviors, but not a genetic risk score, associate with metabolic syndrome in evening chronotypes. Sci Rep. 2018 01 17; 8(1):945. PMID: 29343740.
    View in: PubMed
  10. Collado MC, Engen PA, Bandín C, Cabrera-Rubio R, Voigt RM, Green SJ, Naqib A, Keshavarzian A, Scheer FAJL, Garaulet M. Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study. FASEB J. 2018 Apr; 32(4):2060-2072. PMID: 29233857.
    View in: PubMed
  11. Joustra SD, Gu C, Rohling JHT, Pickering L, Klose M, Hu K, Scheer FA, Feldt-Rasmussen U, Jennum PJ, Pereira AM, Biermasz NR, Meijer JH. Decrease in scale invariance of activity fluctuations with aging and in patients with suprasellar tumors. Chronobiol Int. 2018 Mar; 35(3):368-377. PMID: 29182371.
    View in: PubMed
  12. McHill AW, Phillips AJ, Czeisler CA, Keating L, Yee K, Barger LK, Garaulet M, Scheer FA, Klerman EB. Later circadian timing of food intake is associated with increased body fat. Am J Clin Nutr. 2017 Nov; 106(5):1213-1219. PMID: 28877894.
    View in: PubMed
  13. Dashti HS, Follis JL, Smith CE, Tanaka T, Garaulet M, Gottlieb DJ, Hruby A, Jacques PF, Kiefte-de Jong JC, Lamon-Fava S, Scheer FAJL, Bartz TM, Kovanen L, Wojczynski MK, Frazier-Wood AC, Ahluwalia TS, Perälä MM, Jonsson A, Muka T, Kalafati IP, Mikkilä V, Ordovás JM. Erratum. Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits. Diabetes Care 2015;38:1456-1466. Diabetes Care. 2017 10; 40(10):1420. PMID: 28842526.
    View in: PubMed
  14. Lo MT, Bandin C, Yang HW, Scheer FAJL, Hu K, Garaulet M. CLOCK 3111T/C genetic variant influences the daily rhythm of autonomic nervous function: relevance to body weight control. Int J Obes (Lond). 2018 Feb; 42(2):190-197. PMID: 28736443.
    View in: PubMed
  15. Vetter C, Scheer FAJL. Circadian Biology: Uncoupling Human Body Clocks by Food Timing. Curr Biol. 2017 Jul 10; 27(13):R656-R658. PMID: 28697366.
    View in: PubMed
  16. Li P, Morris CJ, Patxot M, Yugay T, Mistretta J, Purvis TE, Scheer FAJL, Hu K. Reduced Tolerance to Night Shift in Chronic Shift Workers: Insight From Fractal Regulation. Sleep. 2017 07 01; 40(7). PMID: 28838129.
    View in: PubMed
  17. Lopez-Minguez J, Saxena R, Bandín C, Scheer FA, Garaulet M. Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: A randomized, cross-over study. Clin Nutr. 2018 Aug; 37(4):1133-1140. PMID: 28455106.
    View in: PubMed
  18. Tucker MA, Morris CJ, Morgan A, Yang J, Myers S, Pierce JG, Stickgold R, Scheer FAJL. The Relative Impact of Sleep and Circadian Drive on Motor Skill Acquisition and Memory Consolidation. Sleep. 2017 04 01; 40(4). PMID: 28460138.
    View in: PubMed
  19. Morris CJ, Purvis TE, Mistretta J, Hu K, Scheer FAJL. Circadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers. J Biol Rhythms. 2017 04; 32(2):154-164. PMID: 28347188.
    View in: PubMed
  20. Ohayon M, Wickwire EM, Hirshkowitz M, Albert SM, Avidan A, Daly FJ, Dauvilliers Y, Ferri R, Fung C, Gozal D, Hazen N, Krystal A, Lichstein K, Mallampalli M, Plazzi G, Rawding R, Scheer FA, Somers V, Vitiello MV. National Sleep Foundation's sleep quality recommendations: first report. Sleep Health. 2017 02; 3(1):6-19. PMID: 28346153.
    View in: PubMed
  21. Lane JM, Liang J, Vlasac I, Anderson SG, Bechtold DA, Bowden J, Emsley R, Gill S, Little MA, Luik AI, Loudon A, Scheer FA, Purcell SM, Kyle SD, Lawlor DA, Zhu X, Redline S, Ray DW, Rutter MK, Saxena R. Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits. Nat Genet. 2017 Feb; 49(2):274-281. PMID: 27992416.
    View in: PubMed
  22. Scheer F, Spunar P, Wiggermann P, Wissgott C, Andresen R. Mesenteric Panniculitis (MP) in CT - A Predictor of Malignancy? Rofo. 2016 Oct; 188(10):926-32. PMID: 27529397.
    View in: PubMed
  23. van Moorsel D, Hansen J, Havekes B, Scheer FAJL, Jörgensen JA, Hoeks J, Schrauwen-Hinderling VB, Duez H, Lefebvre P, Schaper NC, Hesselink MKC, Staels B, Schrauwen P. Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity. Mol Metab. 2016 Aug; 5(8):635-645. PMID: 27656401.
    View in: PubMed
  24. Hu K, Riemersma-van der Lek RF, Patxot M, Li P, Shea SA, Scheer FA, Van Someren EJ. Progression of Dementia Assessed by Temporal Correlations of Physical Activity: Results From a 3.5-Year, Longitudinal Randomized Controlled Trial. Sci Rep. 2016 06 13; 6:27742. PMID: 27292543.
    View in: PubMed
  25. Carrasco-Benso MP, Rivero-Gutierrez B, Lopez-Minguez J, Anzola A, Diez-Noguera A, Madrid JA, Lujan JA, Martínez-Augustin O, Scheer FA, Garaulet M. Human adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity. FASEB J. 2016 09; 30(9):3117-23. PMID: 27256623; PMCID: PMC5001513 [Available on 09/01/17].
  26. Chang AM, Bjonnes AC, Aeschbach D, Buxton OM, Gooley JJ, Anderson C, Van Reen E, Cain SW, Czeisler CA, Duffy JF, Lockley SW, Shea SA, Scheer FA, Saxena R. Circadian gene variants influence sleep and the sleep electroencephalogram in humans. Chronobiol Int. 2016; 33(5):561-73. PMID: 27089043.
    View in: PubMed
  27. Qian J, Scheer FAJL. Circadian System and Glucose Metabolism: Implications for Physiology and Disease. Trends Endocrinol Metab. 2016 05; 27(5):282-293. PMID: 27079518.
    View in: PubMed
  28. Johnston JD, Ordovás JM, Scheer FA, Turek FW. Circadian Rhythms, Metabolism, and Chrononutrition in Rodents and Humans. Adv Nutr. 2016 Mar; 7(2):399-406. PMID: 26980824; PMCID: PMC4785478 [Available on 03/01/17].
  29. Lane JM, Vlasac I, Anderson SG, Kyle SD, Dixon WG, Bechtold DA, Gill S, Little MA, Luik A, Loudon A, Emsley R, Scheer FA, Lawlor DA, Redline S, Ray DW, Rutter MK, Saxena R. Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank. Nat Commun. 2016 Mar 09; 7:10889. PMID: 26955885.
    View in: PubMed
  30. Scheer FA. Hungry for Sleep: A Role for Endocannabinoids? Sleep. 2016 Mar 01; 39(3):495-6. PMID: 26856900; PMCID: PMC4763352.
  31. Ruiz-Lozano T, Vidal J, de Hollanda A, Scheer FAJL, Garaulet M, Izquierdo-Pulido M. Timing of food intake is associated with weight loss evolution in severe obese patients after bariatric surgery. Clin Nutr. 2016 12; 35(6):1308-1314. PMID: 26948400.
    View in: PubMed
  32. Lane JM, Chang AM, Bjonnes AC, Aeschbach D, Anderson C, Cade BE, Cain SW, Czeisler CA, Gharib SA, Gooley JJ, Gottlieb DJ, Grant SF, Klerman EB, Lauderdale DS, Lockley SW, Munch M, Patel S, Punjabi NM, Rajaratnam SM, Rueger M, St Hilaire MA, Santhi N, Scheuermaier K, Van Reen E, Zee PC, Shea SA, Duffy JF, Buxton OM, Redline S, Scheer FA, Saxena R. Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology. Diabetes. 2016 06; 65(6):1741-51. PMID: 26868293; PMCID: PMC4878414 [Available on 06/01/17].
  33. Dashti HS, Zuurbier LA, de Jonge E, Voortman T, Jacques PF, Lamon-Fava S, Scheer FA, Kiefte-De Jong JC, Hofman A, Ordovás JM, Franco OH, Tiemeier H. Actigraphic sleep fragmentation, efficiency and duration associate with dietary intake in the Rotterdam Study. J Sleep Res. 2016 08; 25(4):404-11. PMID: 26857552; PMCID: PMC4980236 [Available on 08/01/17].
  34. Morris CJ, Purvis TE, Hu K, Scheer FA. Circadian misalignment increases cardiovascular disease risk factors in humans. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):E1402-11. PMID: 26858430; PMCID: PMC4790999.
  35. Morris CJ, Purvis TE, Mistretta J, Scheer FA. Effects of the Internal Circadian System and Circadian Misalignment on Glucose Tolerance in Chronic Shift Workers. J Clin Endocrinol Metab. 2016 Mar; 101(3):1066-74. PMID: 26771705; PMCID: PMC4803172 [Available on 03/01/17].
  36. Arble DM, Bass J, Behn CD, Butler MP, Challet E, Czeisler C, Depner CM, Elmquist J, Franken P, Grandner MA, Hanlon EC, Keene AC, Joyner MJ, Karatsoreos I, Kern PA, Klein S, Morris CJ, Pack AI, Panda S, Ptacek LJ, Punjabi NM, Sassone-Corsi P, Scheer FA, Saxena R, Seaquest ER, Thimgan MS, Van Cauter E, Wright KP. Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions. Sleep. 2015 Dec 01; 38(12):1849-60. PMID: 26564131; PMCID: PMC4667373.
  37. Dashti HS, Scheer FA, Jacques PF, Lamon-Fava S, Ordovás JM. Short sleep duration and dietary intake: epidemiologic evidence, mechanisms, and health implications. Adv Nutr. 2015 Nov; 6(6):648-59. PMID: 26567190; PMCID: PMC4642416 [Available on 11/01/16].
  38. Morris CJ, Garcia JI, Myers S, Yang JN, Trienekens N, Scheer FA. The Human Circadian System Has a Dominating Role in Causing the Morning/Evening Difference in Diet-Induced Thermogenesis. Obesity (Silver Spring). 2015 Oct; 23(10):2053-8. PMID: 26414564; PMCID: PMC4602397 [Available on 10/01/16].
  39. Garaulet M, Gómez-Abellán P, Rubio-Sastre P, Madrid JA, Saxena R, Scheer FA. Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans. Metabolism. 2015 Dec; 64(12):1650-7. PMID: 26440713; PMCID: PMC4856010 [Available on 12/01/16].
  40. Dashti HS, Follis JL, Smith CE, Tanaka T, Garaulet M, Gottlieb DJ, Hruby A, Jacques PF, Kiefte-de Jong JC, Lamon-Fava S, Scheer FA, Bartz TM, Kovanen L, Wojczynski MK, Frazier-Wood AC, Ahluwalia TS, Perälä MM, Jonsson A, Muka T, Kalafati IP, Mikkilä V, Ordovás JM. Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits. Diabetes Care. 2015 Aug; 38(8):1456-66. PMID: 26084345.
    View in: PubMed
  41. Dashti HS, Aslibekyan S, Scheer FA, Smith CE, Lamon-Fava S, Jacques P, Lai CQ, Tucker KL, Arnett DK, Ordovás JM. Clock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature. Am J Hypertens. 2016 Jan; 29(1):132-40. PMID: 26045533.
    View in: PubMed
  42. Morris CJ, Yang JN, Garcia JI, Myers S, Bozzi I, Wang W, Buxton OM, Shea SA, Scheer FA. Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans. Proc Natl Acad Sci U S A. 2015 Apr 28; 112(17):E2225-34. PMID: 25870289; PMCID: PMC4418873.
  43. Burke TM, Scheer FAJL, Ronda JM, Czeisler CA, Wright KP. Sleep inertia, sleep homeostatic and circadian influences on higher-order cognitive functions. J Sleep Res. 2015 Aug; 24(4):364-371. PMID: 25773686.
    View in: PubMed
  44. Gu C, Coomans CP, Hu K, Scheer FA, Stanley HE, Meijer JH. Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2320-4. PMID: 25675516; PMCID: PMC4345576.
  45. Dashti HS, Follis JL, Smith CE, Tanaka T, Cade BE, Gottlieb DJ, Hruby A, Jacques PF, Lamon-Fava S, Richardson K, Saxena R, Scheer FA, Kovanen L, Bartz TM, Perälä MM, Jonsson A, Frazier-Wood AC, Kalafati IP, Mikkilä V, Partonen T, Lemaitre RN, Lahti J, Hernandez DG, Toft U, Johnson WC, Kanoni S, Raitakari OT, Perola M, Psaty BM, Ferrucci L, Grarup N, Highland HM, Rallidis L, Kähönen M, Havulinna AS, Siscovick DS, Räikkönen K, Jørgensen T, Rotter JI, Deloukas P, Viikari JS, Mozaffarian D, Linneberg A, Seppälä I, Hansen T, Salomaa V, Gharib SA, Eriksson JG, Bandinelli S, Pedersen O, Rich SS, Dedoussis G, Lehtimäki T, Ordovás JM. Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants. Am J Clin Nutr. 2015 Jan; 101(1):135-43. PMID: 25527757; PMCID: PMC4266883.
  46. Mattson MP, Allison DB, Fontana L, Harvie M, Longo VD, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FA, Seyfried TN, Varady KA, Panda S. Meal frequency and timing in health and disease. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16647-53. PMID: 25404320; PMCID: PMC4250148.
  47. Rahman SA, Castanon-Cervantes O, Scheer FA, Shea SA, Czeisler CA, Davidson AJ, Lockley SW. Endogenous circadian regulation of pro-inflammatory cytokines and chemokines in the presence of bacterial lipopolysaccharide in humans. Brain Behav Immun. 2015 Jul; 47:4-13. PMID: 25452149.
    View in: PubMed
  48. Bandín C, Scheer FA, Luque AJ, Ávila-Gandía V, Zamora S, Madrid JA, Gómez-Abellán P, Garaulet M. Meal timing affects glucose tolerance, substrate oxidation and circadian-related variables: A randomized, crossover trial. Int J Obes (Lond). 2015 May; 39(5):828-33. PMID: 25311083.
    View in: PubMed
  49. Rubio-Sastre P, Scheer FA, Gómez-Abellán P, Madrid JA, Garaulet M. Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening. Sleep. 2014 Oct 01; 37(10):1715-9. PMID: 25197811; PMCID: PMC4173928.
  50. Nedeltcheva AV, Scheer FA. Metabolic effects of sleep disruption, links to obesity and diabetes. Curr Opin Endocrinol Diabetes Obes. 2014 Aug; 21(4):293-8. PMID: 24937041; PMCID: PMC4370346.
  51. Hsieh WH, Escobar C, Yugay T, Lo MT, Pittman-Polletta B, Salgado-Delgado R, Scheer FA, Shea SA, Buijs RM, Hu K. Simulated shift work in rats perturbs multiscale regulation of locomotor activity. J R Soc Interface. 2014 Jul 06; 11(96). PMID: 24829282; PMCID: PMC4032547.
  52. Buijs FN, Cazarez F, Basualdo MC, Scheer FA, Perusquía M, Centurion D, Buijs RM. The suprachiasmatic nucleus is part of a neural feedback circuit adapting blood pressure response. Neuroscience. 2014 Apr 25; 266:197-207. PMID: 24583038.
    View in: PubMed
  53. Tare A, Lane JM, Cade BE, Grant SF, Chen TH, Punjabi NM, Lauderdale DS, Zee PC, Gharib SA, Gottlieb DJ, Scheer FA, Redline S, Saxena R. Sleep duration does not mediate or modify association of common genetic variants with type 2 diabetes. Diabetologia. 2014 Feb; 57(2):339-46. PMID: 24280871; PMCID: PMC4006271.
  54. Scheer FA, Shea SA. Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle. Blood. 2014 Jan 23; 123(4):590-3. PMID: 24200683; PMCID: PMC3901072.
  55. Chang AM, Scheer FA, Czeisler CA, Aeschbach D. Direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans depend on prior light history. Sleep. 2013 Aug 01; 36(8):1239-46. PMID: 23904684; PMCID: PMC3700721.
  56. Lane JM, Tare A, Cade BE, Chen TH, Punjabi NM, Gottlieb DJ, Scheer FA, Redline S, Saxena R. Common variants in CLOCK are not associated with measures of sleep duration in people of european ancestry from the sleep heart health study. Biol Psychiatry. 2013 Dec 15; 74(12):e33-5. PMID: 23871470; PMCID: PMC4157567.
  57. Pittman-Polletta BR, Scheer FA, Butler MP, Shea SA, Hu K. The role of the circadian system in fractal neurophysiological control. Biol Rev Camb Philos Soc. 2013 Nov; 88(4):873-94. PMID: 23573942; PMCID: PMC3766492.
  58. Morris CJ, Hastings JA, Boyd K, Krainski F, Perhonen MA, Scheer FA, Levine BD. Day/night variability in blood pressure: influence of posture and physical activity. Am J Hypertens. 2013 Jun; 26(6):822-8. PMID: 23535155; PMCID: PMC3693479.
  59. Scheer FA, Morris CJ, Shea SA. The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors. Obesity (Silver Spring). 2013 Mar; 21(3):421-3. PMID: 23456944; PMCID: PMC3655529.
  60. Garaulet M, Gómez-Abellán P, Alburquerque-Béjar JJ, Lee YC, Ordovás JM, Scheer FA. Timing of food intake predicts weight loss effectiveness. Int J Obes (Lond). 2013 Apr; 37(4):604-11. PMID: 23357955; PMCID: PMC3756673.
  61. Wu YH, Ursinus J, Zhou JN, Scheer FA, Ai-Min B, Jockers R, van Heerikhuize J, Swaab DF. Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression. J Affect Disord. 2013 Jun; 148(2-3):357-67. PMID: 23357659.
    View in: PubMed
  62. Hu K, Harper DG, Shea SA, Stopa EG, Scheer FA. Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia. Sci Rep. 2013; 3:2229. PMID: 23863985; PMCID: PMC3714649.
  63. Hu K, Meijer JH, Shea SA, vanderLeest HT, Pittman-Polletta B, Houben T, van Oosterhout F, Deboer T, Scheer FA. Fractal patterns of neural activity exist within the suprachiasmatic nucleus and require extrinsic network interactions. PLoS One. 2012; 7(11):e48927. PMID: 23185285; PMCID: PMC3502397.
  64. Scheer FA, Morris CJ, Garcia JI, Smales C, Kelly EE, Marks J, Malhotra A, Shea SA. Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial. Sleep. 2012 Oct 01; 35(10):1395-402. PMID: 23024438; PMCID: PMC3443766.
  65. Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, Jain MK. Klf15 orchestrates circadian nitrogen homeostasis. Cell Metab. 2012 Mar 07; 15(3):311-23. PMID: 22405069; PMCID: PMC3299986.
  66. Morris CJ, Yang JN, Scheer FA. The impact of the circadian timing system on cardiovascular and metabolic function. Prog Brain Res. 2012; 199:337-58. PMID: 22877674; PMCID: PMC3704149.
  67. Morris CJ, Aeschbach D, Scheer FA. Circadian system, sleep and endocrinology. Mol Cell Endocrinol. 2012 Feb 05; 349(1):91-104. PMID: 21939733; PMCID: PMC3242827.
  68. Scheer FA, Michelson AD, Frelinger AL, Evoniuk H, Kelly EE, McCarthy M, Doamekpor LA, Barnard MR, Shea SA. The human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors. PLoS One. 2011; 6(9):e24549. PMID: 21931750; PMCID: PMC3169622.
  69. Shea SA, Hilton MF, Hu K, Scheer FA. Existence of an endogenous circadian blood pressure rhythm in humans that peaks in the evening. Circ Res. 2011 Apr 15; 108(8):980-4. PMID: 21474818; PMCID: PMC3086568.
  70. Kalsbeek A, Scheer FA, Perreau-Lenz S, La Fleur SE, Yi CX, Fliers E, Buijs RM. Circadian disruption and SCN control of energy metabolism. FEBS Lett. 2011 May 20; 585(10):1412-26. PMID: 21414317; PMCID: PMC3095769.
  71. Hu K, Scheer FA, Laker M, Smales C, Shea SA. Endogenous circadian rhythm in vasovagal response to head-up tilt. Circulation. 2011 Mar 08; 123(9):961-70. PMID: 21339480; PMCID: PMC3089897.
  72. Chang AM, Scheer FA, Czeisler CA. The human circadian system adapts to prior photic history. J Physiol. 2011 Mar 01; 589(Pt 5):1095-102. PMID: 21224217; PMCID: PMC3060589.
  73. Scheer FA, Hu K, Evoniuk H, Kelly EE, Malhotra A, Hilton MF, Shea SA. Impact of the human circadian system, exercise, and their interaction on cardiovascular function. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20541-6. PMID: 21059915; PMCID: PMC2996667.
  74. Scheer FA, Chan JL, Fargnoli J, Chamberland J, Arampatzi K, Shea SA, Blackburn GL, Mantzoros CS. Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions. Diabetologia. 2010 Nov; 53(11):2401-5. PMID: 20703446; PMCID: PMC3111077.
  75. Jung CM, Khalsa SB, Scheer FA, Cajochen C, Lockley SW, Czeisler CA, Wright KP. Acute effects of bright light exposure on cortisol levels. J Biol Rhythms. 2010 Jun; 25(3):208-16. PMID: 20484692; PMCID: PMC3686562.
  76. Rüger M, Scheer FA. Effects of circadian disruption on the cardiometabolic system. Rev Endocr Metab Disord. 2009 Dec; 10(4):245-60. PMID: 19784781; PMCID: PMC3026852.
  77. Pavlova MK, Shea SA, Scheer FA, Bromfield EB. Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy? Epilepsy Behav. 2009 Nov; 16(3):461-7. PMID: 19786369; PMCID: PMC3861150.
  78. Litinski M, Scheer FA, Shea SA. Influence of the Circadian System on Disease Severity. Sleep Med Clin. 2009 Jun 01; 4(2):143-163. PMID: 20161149.
    View in: PubMed
  79. Scheer FA, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4453-8. PMID: 19255424; PMCID: PMC2657421.
  80. Hu K, Van Someren EJ, Shea SA, Scheer FA. Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2490-4. PMID: 19202078; PMCID: PMC2650290.
  81. Scheer FA, Shea TJ, Hilton MF, Shea SA. An endogenous circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night. J Biol Rhythms. 2008 Aug; 23(4):353-61. PMID: 18663242; PMCID: PMC3130065.
  82. Hu K, Scheer FA, Buijs RM, Shea SA. The circadian pacemaker generates similar circadian rhythms in the fractal structure of heart rate in humans and rats. Cardiovasc Res. 2008 Oct 01; 80(1):62-8. PMID: 18539630; PMCID: PMC2732059.
  83. Hu K, Scheer FA, Buijs RM, Shea SA. The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours. J Biol Rhythms. 2008 Jun; 23(3):265-73. PMID: 18487418; PMCID: PMC2885843.
  84. Hu K, Scheer FA, Ivanov PCh, Buijs RM, Shea SA. The suprachiasmatic nucleus functions beyond circadian rhythm generation. Neuroscience. 2007 Nov 09; 149(3):508-17. PMID: 17920204; PMCID: PMC2759975.
  85. Scheer FA, Wright KP, Kronauer RE, Czeisler CA. Plasticity of the intrinsic period of the human circadian timing system. PLoS One. 2007 Aug 08; 2(8):e721. PMID: 17684566; PMCID: PMC1934931.
  86. Scheer FA, Stone PH, Shea SA. Decreased sleep in heart failure: are medications to blame? Arch Intern Med. 2007 May 28; 167(10):1098-9; author reply 1099-100. PMID: 17533214.
    View in: PubMed
  87. Shea SA, Hu K, Buijs RM, Scheer FAJL. Lesioning the suprachiasmatic nucleus abolishes ultradian rhythms of locomotor activity in rats. Sleep. 2007; 30:A58.
  88. Scheer FAJL, Hilton MF, Benjamin T, Barb D, Evoniuk H, Mantzoros CS, Shea SA. . Desynchrony between sleep-wake cycle and circadian cycle leads to suppressed plasma leptin; potential relevance for shift workers. Sleep. 2007; 30:A61.
  89. Hu K, Scheer FAJL, Buijs RM, Shea SA. The circadian pacemaker contributes to intrinsic scale-invariant patterns of cardiac dynamics across a wide range of time scales – Spanning 4-24 Hours. Sleep. 2007; 30:A58.
  90. Hu K, Scheer FAJL, Buijs RM, Shea SA. Effect of lesioning the suprachiasmatic nucleus on fractal pattern of heart rate fluctuations. Sleep. 2007; 30:A64.
  91. Shea SA, Scheer FAJL, Hilton MF. Predicting the daily pattern of asthma severity based on the relative contribution of the circadian timing system, the sleep-wake cycle and the environment. Sleep. 2007; 30:A65.
  92. Scheer FAJL, Hahn M, Doamekpor LA, Evoniuk H, Kelly K, Laker MD, Shea SA. Lack of endogenous circadian rhythm of platelet aggregability. Sleep. 2007; 30:A64.
  93. Kalsbeek A, Palm IF, La Fleur SE, Scheer FA, Perreau-Lenz S, Ruiter M, Kreier F, Cailotto C, Buijs RM. SCN outputs and the hypothalamic balance of life. J Biol Rhythms. 2006 Dec; 21(6):458-69. PMID: 17107936.
    View in: PubMed
  94. Lockley SW, Evans EE, Scheer FA, Brainard GC, Czeisler CA, Aeschbach D. Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans. Sleep. 2006 Feb; 29(2):161-8. PMID: 16494083.
    View in: PubMed
  95. Scheer FA, Zeitzer JM, Ayas NT, Brown R, Czeisler CA, Shea SA. Reduced sleep efficiency in cervical spinal cord injury; association with abolished night time melatonin secretion. Spinal Cord. 2006 Feb; 44(2):78-81. PMID: 16130027; PMCID: PMC2882209.
  96. Frank A.J.L. Scheer, Thomas J. Shea, Heather L. Evoniuk, Michael F. Hilton. Circadian Rhythm in Degree of Sleep Inertia Following Awakening. J Sleep Res. 2006; 15(1):55.
  97. Buijs RM, Scheer FA, Kreier F, Yi C, Bos N, Goncharuk VD, Kalsbeek A. Organization of circadian functions: interaction with the body. Prog Brain Res. 2006; 153:341-60. PMID: 16876585.
    View in: PubMed
  98. Shea TJ, Hilton MF, Evoniuk H, Scheer FAJL. Circadian effect on degree of sleep inertia present after awakening. Sleep. 2006; A67.
  99. Evoniuk HL, Scheer FAJL, Hilton MF, Schory KE, Shea SA. Challenges to sleep in asthma studied under baseline conditions, reduced homeostatic sleep drive, and adverse circadian phase for sleep. Sleep. 2006.
  100. Frank A.J.L. Scheer. Suprachiasmatic nucleus, environmental light, and metabolic state interact in the regulation of body temperature. J Sleep Res. 2006; 15(1):20.
  101. Scheer FAJL. Suprachiasmatic nucleus, environmental light, and metabolic state interact in the regulation of body temperature. J Sleep Res. 2006; 20.
  102. Thomas J Shea, Michael F Hilton, Heather L Evoniuk, Frank AJL Scheer. Circadian Effect on Degree of Sleep Inertia Present After Awakening. Sleep. 2006; 29:A67.
  103. Kun Hu, Frank A.J.L. Scheer, Plamen Ch. Ivanov, Ruud M. Buijs, Steven A. Shea. Intrinsic scale-invariant patterns of locomotor activity: role of the circadian pacemaker across a wide range of time scales – spanning 4-24 hours. Sleep. 2006; 29:A64.
  104. Scheer FA. Potential use of melatonin as adjunct antihypertensive therapy. Am J Hypertens. 2005 Dec; 18(12 Pt 1):1619-20. PMID: 16364835.
    View in: PubMed
  105. Scheer FA, Czeisler CA. Melatonin, sleep, and circadian rhythms. Sleep Med Rev. 2005 Feb; 9(1):5-9. PMID: 15649734.
    View in: PubMed
  106. Shea SA, Scheer FAJL, Evoniuk HL, Shiels SA, Malhotra A, Sugarbaker R, Ayers RT, Okruch A, Weiner M, Rinzler S, Massaro AF, Hilton MF. Role of the endogenous circadian system in bronchoconstriction, airway inflammation and rescue medication use in asthma. Chronobiology Int. 2005.
  107. Scheer FAJL, Cajochen C, Turek FW, Czeisler CA. . Melatonin in the regulation of sleep and circadian rhythms. Kryger MH, Roth T, Dement WC (ed). Principles and Practice of Sleep Medicine. 2005; 395-404.
  108. Scheer FAJL, Wright Jr. KP, Gronfier C, Kronauer RE, Czeisler CA. Human circadian period is influenced by entrainment to non-24 hour schedules. Sleep. 2005; 28:A72.
  109. Scheer FA, Pirovano C, Van Someren EJ, Buijs RM. Environmental light and suprachiasmatic nucleus interact in the regulation of body temperature. Neuroscience. 2005; 132(2):465-77. PMID: 15802197.
    View in: PubMed
  110. Shea SA, Hilton MF, Malhotra A, Evoniuk H, Shiels S, Sugarbaker R, Ayers RT, Weiner M, Massaro AF, Scheer FAJL. . Interaction between effects of the circadian pacemaker and behavioral sleep-wake cycle on pulmonary function in asthma. Sleep. 2005; 28:A73.
  111. Jung CM, Khalsa S, Scheer FA, Czeisler CA, Wright KP. Acute effects of bright light exposure on nighttime cortisol levels in humans. Sleep. 2005; 28:A59.
  112. Evoniuk H, Hilton MF, Scheer FAJL, Malhotra A, Shiels S, Sugarbaker R, Weiner M, Ayers RT, Massaro AF, Shea SA. Effects of endogenous circadian rhythms, sleep and sleep deprivation on airway function in asthma explored with a constant routine protocol. Sleep. 2005; 28:A71.
  113. Scheer FA, Van Doornen LJ, Buijs RM. Light and diurnal cycle affect autonomic cardiac balance in human; possible role for the biological clock. Auton Neurosci. 2004 Jan 30; 110(1):44-8. PMID: 14766324.
    View in: PubMed
  114. Scheer FA, Van Montfrans GA, van Someren EJ, Mairuhu G, Buijs RM. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension. 2004 Feb; 43(2):192-7. PMID: 14732734.
    View in: PubMed
  115. Scheer FAJL, Van Montfrans GA, Buijs RM. . Chronic, but not acute, nighttime melatonin administration improves sleep quality in hypertensive patients. Sleep. 2004; 27:A329.
  116. Shea SA, Hilton MF, Scheer FA, Ayers R, Evoniuk HL, Shiels SA, Sugarbaker RJ, Malhotra A, Massaro AF. An endogenous circadian rhythm in bronchodilator rescue medication use in asthma. Sleep. 2004; 27:A81.
  117. Scheer FA, Kalsbeek A, Buijs RM. Cardiovascular control by the suprachiasmatic nucleus: neural and neuroendocrine mechanisms in human and rat. Biol Chem. 2003 May; 384(5):697-709. PMID: 12817466.
    View in: PubMed
  118. Scheer FA, Van Paassen B, Van Montfrans GA, Fliers E, Van Someren EJ, Van Heerikhuize JJ, Buijs RM. Human basal cortisol levels are increased in hospital compared to home setting. Neurosci Lett. 2002 Nov 22; 333(2):79-82. PMID: 12419485.
    View in: PubMed
  119. Scheer FA, Ter Horst GJ, van Der Vliet J, Buijs RM. Physiological and anatomic evidence for regulation of the heart by suprachiasmatic nucleus in rats. Am J Physiol Heart Circ Physiol. 2001 Mar; 280(3):H1391-9. PMID: 11179089.
    View in: PubMed
  120. Buijs RM, Hermes MLHJ, Dai J, Scheer FAJL, Kalsbeek A. Circadian organization of the autonomic Nervous system. Ter Horst GJ (ed). The Nervous System and the Heart. 2000; 117-157.
  121. Scheer FA, Buijs RM. Light affects morning salivary cortisol in humans. J Clin Endocrinol Metab. 1999 Sep; 84(9):3395-8. PMID: 10487717.
    View in: PubMed
  122. Scheer FA, van Doornen LJ, Buijs RM. Light and diurnal cycle affect human heart rate: possible role for the circadian pacemaker. J Biol Rhythms. 1999 Jun; 14(3):202-12. PMID: 10452332.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at For faculty personal and demographic information, contact HMS Office for Faculty Affairs at
Scheer's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (280)
Co-Authors (32)
Similar People (60)
Same Department 
Physical Neighbors
Tool Page Footer - Harvard Catalyst Tool Page Footer – Harvard Catalyst
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.