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Frank A.J.L. Scheer, Ph.D.

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Utrecht University, Utrecht, The NetherlandsBS05/1995Biology
Utrecht University, Utrecht, The NetherlandsMSc05/1997Neurophysiology
Netherlands Institute for Brain Research, Amsterdam, The NetherlandsPhD01/2003Neuroscience
Harvard Medical School, Brigham and Women’s Hospital, Boston, USAPostdoctoral06/2005Sleep Medicine
2005 - 2007
Pickwick Postdoctoral Fellowship, National Sleep Foundation
Young Investigator Neurology Section Award, American Academy of Sleep Medicine
Alliance Chronosleep Award, European Sleep Research Society
Finalist Helgi Kristbjarnarson's Award, European Sleep Research Society
Young Investigator Award, American Academy of Sleep Medicine
1st Place Clinical Research Young Investigator Award, National Sleep Foundation/Sleep Research Socie
Neal Miller Award, Academy of Behavioral Medicine Research
Young Investigator Award, Honorable Mention, Sleep Research Society
Nominated for the 2013-2014 Harold Amos Faculty Diversity Award, Harvard Medical School
Nominated for 2014-2015 A. Clifford Barger Excellence in Mentoring Award, Harvard Medical School
Outstanding Scientific Achievement Award, Sleep Research Society

Dr. Frank A.J.L. Scheer is a Professor of Medicine at Harvard Medical School (HMS) and the Director of the Medical Chronobiology Program at Brigham and Women’s Hospital (BWH), Boston. Dr. Scheer’s work focuses on influences of the endogenous circadian system and its disruption—such as with shift work—on cardiovascular, pulmonary, and metabolic regulation and disease states, including hypertension, asthma, obesity and diabetes. Since 2005, Dr. Scheer has been funded continuously as Principal Investigator by the National Institutes of Health (NIH). Dr. Scheer has received numerous scientific awards, including the Young Investigator Award by the American Academy of Sleep Medicine, the Neal Miller Award by the Academy of Behavioral Medicine Research, and the Outstanding Scientific Achievement Award by the Sleep Research Society. Dr. Scheer is an Editorial Board Member of several peer-reviewed journals, including the American Journal of Cardiovascular Disease, the Neurobiology of Sleep and Circadian Rhythms, and is an Associate Editor at the journal SLEEP. He is a Member the Board of Directors of the Sleep Research Society.

- Undergraduate: Taneisha Benjamin, 2005; Thomas J. Shea, 2006-2007; Anna Dowdle, 2006-2008; Grace McKay-Corkum, 2012; Isadora Bozzi, 2012-2013; Lucas Vargas, 2013; Seth Morrison, 2019
- Masters: Mariya Kogan, 2007-2008; Kirk Krogsted, 2007-2013; Noortje Trienekens, 2011-2012; Ann-Cathrin Plennis, 2015;
- PhD student: Yolanda Larriba, 2019 (internship)
- Post-doctoral: Anne-Marie Chang, PhD, 2005 - 2011; Kun Hu, PhD, 2006-2007; Mikhail Litinski, MD, 2008-2009; Christopher J. Morris, PhD, 2010-2015; Wenli Zhang, MD 2011-2012; Matthew Butler, PhD 2011-2013; David Barr, PhD 2013-2015; Jingyi Qian, PhD 2015-present; Sarah Chellappa, PhD 2016-present; Nina Vujovic, PhD, 2017-present; Ivy Cheung Mason, PhD, 2018-present

- Course Co-Director (with Charles A. Czeisler), MCB 186, Sleep and Circadian Clocks: from Biology to Public Health, Harvard College, Cambridge, MA
- General Education Course Co-Director (with Charles A. Czeisler), Gen Ed 1038, Sleep, Harvard College, Cambridge, MA

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL140574 (SCHEER, FRANK A) Sep 15, 2017 - May 31, 2022
    Role of Meal Timing in Efficacy of Bariatric Surgery in Obese Individuals
    Role: Principal Investigator
  2. R01DK105072 (SAXENA, RICHA) Jun 1, 2016 - May 31, 2021
    Impact of malatonin, food timing and receptor variant on type 2 diabetes risk
    Role: Co-Principal Investigator
  3. R01DK102696 (SCHEER, FRANK A) Aug 19, 2015 - May 31, 2020
    Melatonin and Receptor Gene Variant: Linking Circadian System and Type 2 Diabetes
    Role: Co-Principal Investigator
  4. R01HL118601 (SCHEER, FRANK A) Jun 1, 2014 - Mar 31, 2018
    Development of countermeasures against adverse metabolic effects of shift work
    Role: Principal Investigator
  5. R01DK099512 (SCHEER, FRANK A) May 15, 2014 - Apr 30, 2018
    Meal Time Effects on Metabolic Health.
    Role: Principal Investigator

Featured Content

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Qian J, Scheer FA, Hu K, Shea SA. The circadian system modulates the rate of recovery of systolic blood pressure after exercise in humans. Sleep. 2020 Apr 15; 43(4). PMID: 31616941.
  2. Kosmadopoulos A, Kervezee L, Boudreau P, Gonzales-Aste F, Vujovic N, Scheer FAJL, Boivin DB. Effects of Shift Work on the Eating Behavior of Police Officers on Patrol. Nutrients. 2020 Apr 04; 12(4). PMID: 32260404.
  3. Knapen SE, Li P, Riemersma-van der Lek RF, Verkooijen S, Boks MPM, Schoevers RA, Scheer FAJL, Hu K. Fractal biomarker of activity in patients with bipolar disorder. Psychol Med. 2020 Apr 01; 1-8. PMID: 32234100.
  4. Butler MP, Thosar SS, Smales C, DeYoung PN, Wu H, Hussain MV, Morimoto M, Hu K, Scheer FAJL, Shea SA. Effects of obstructive sleep apnea on endogenous circadian rhythms assessed during relaxed wakefulness; an exploratory analysis. Chronobiol Int. 2020 Mar 20; 1-11. PMID: 32192382.
  5. Sletten TL, Cappuccio FP, Davidson AJ, Van Cauter E, Rajaratnam SMW, Scheer FAJL. Health consequences of circadian disruption. Sleep. 2020 01 13; 43(1). PMID: 31930347.
  6. Mason IC, Qian J, Adler GK, Scheer FAJL. Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes. Diabetologia. 2020 03; 63(3):462-472. PMID: 31915891.
  7. Garaulet M, Qian J, Florez JC, Arendt J, Saxena R, Scheer FAJL. Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy. Trends Endocrinol Metab. 2020 Mar; 31(3):192-204. PMID: 31901302.
  8. Qian J, Scheer FAJL. Sex-dependent link between circadian misalignment and adiposity. Nat Rev Endocrinol. 2020 01; 16(1):13-15. PMID: 31723227.
  9. Dashti HS, Vetter C, Lane JM, Smith MC, Wood AR, Weedon MN, Rutter MK, Garaulet M, Scheer FAJL, Saxena R. Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank. Diabetes. 2020 02; 69(2):259-266. PMID: 31757795.
  10. Qian J, Morris CJ, Caputo R, Wang W, Garaulet M, Scheer FAJL. Sex differences in the circadian misalignment effects on energy regulation. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23806-23812. PMID: 31685618.
  11. Chellappa SL, Vujovic N, Williams JS, Scheer FAJL. Impact of Circadian Disruption on Cardiovascular Function and Disease. Trends Endocrinol Metab. 2019 10; 30(10):767-779. PMID: 31427142.
  12. Wang H, Lane JM, Jones SE, Dashti HS, Ollila HM, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojärvi K, Palviainen T, Cade BE, Sofer T, Song Y, Patel K, Anderson SG, Bechtold DA, Bowden J, Emsley R, Kyle SD, Little MA, Loudon AS, Scheer FAJL, Purcell SM, Richmond RC, Spiegelhalder K, Tyrrell J, Zhu X, Hublin C, Kaprio JA, Kristiansson K, Sulkava S, Paunio T, Hveem K, Nielsen JB, Willer CJ, Zwart JA, Strand LB, Frayling TM, Ray D, Lawlor DA, Rutter MK, Weedon MN, Redline S, Saxena R. Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes. Nat Commun. 2019 08 13; 10(1):3503. PMID: 31409809.
  13. Dashti HS, Merino J, Lane JM, Song Y, Smith CE, Tanaka T, McKeown NM, Tucker C, Sun D, Bartz TM, Li-Gao R, Nisa H, Reutrakul S, Lemaitre RN, Alshehri TM, de Mutsert R, Bazzano L, Qi L, Knutson KL, Psaty BM, Mook-Kanamori DO, Perica VB, Neuhouser ML, Scheer FAJL, Rutter MK, Garaulet M, Saxena R. Genome-wide association study of breakfast skipping links clock regulation with food timing. Am J Clin Nutr. 2019 08 01; 110(2):473-484. PMID: 31190057.
  14. Dashti HS, Scheer FAJL, Saxena R, Garaulet M. Timing of Food Intake: Identifying Contributing Factors to Design Effective Interventions. Adv Nutr. 2019 07 01; 10(4):606-620. PMID: 31046092.
  15. Guirette M, Dashti H, Tucker C, Vetter C, Garaulet M, Scheer F, Saxena R. How Accurately Can We Recall Food Timing? A Validity Study of a Novel Food Timing Questionnaire (P18-016-19). Curr Dev Nutr. 2019 Jun; 3(Suppl 1). PMID: 31223959.
  16. Gao L, Li P, Hu C, To T, Patxot M, Falvey B, Wong PM, Scheer FAJL, Lin C, Lo MT, Hu K. Nocturnal heart rate variability moderates the association between sleep-wake regularity and mood in young adults. Sleep. 2019 05 01; 42(5). PMID: 30722058.
  17. Vetter C, Scheer FAJL. A healthy lifestyle - reducing T2DM risk in shift workers? Nat Rev Endocrinol. 2019 04; 15(4):194-196. PMID: 30718862.
  18. Chang AM, Duffy JF, Buxton OM, Lane JM, Aeschbach D, Anderson C, Bjonnes AC, Cain SW, Cohen DA, Frayling TM, Gooley JJ, Jones SE, Klerman EB, Lockley SW, Munch M, Rajaratnam SMW, Rueger M, Rutter MK, Santhi N, Scheuermaier K, Van Reen E, Weedon MN, Czeisler CA, Scheer FAJL, Saxena R. Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans. Sci Rep. 2019 03 29; 9(1):5350. PMID: 30926824.
  19. McHill AW, Czeisler CA, Phillips AJK, Keating L, Barger LK, Garaulet M, Scheer FAJL, Klerman EB. Caloric and Macronutrient Intake Differ with Circadian Phase and between Lean and Overweight Young Adults. Nutrients. 2019 03 11; 11(3). PMID: 30862011.
  20. Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Bowden J, Cade BE, Garaulet M, Kyle SD, Little MA, Loudon AS, Luik AI, Scheer FAJL, Spiegelhalder K, Tyrrell J, Gottlieb DJ, Tiemeier H, Ray DW, Purcell SM, Frayling TM, Redline S, Lawlor DA, Rutter MK, Weedon MN, Saxena R. Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Nat Commun. 2019 03 07; 10(1):1100. PMID: 30846698.
  21. Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Cade BE, Haas M, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, Scheer FAJL, Schormair B, Tyrrell J, Winkelman JW, Winkelmann J, Hveem K, Zhao C, Nielsen JB, Willer CJ, Redline S, Spiegelhalder K, Kyle SD, Ray DW, Zwart JA, Brumpton B, Frayling TM, Lawlor DA, Rutter MK, Weedon MN, Saxena R. Biological and clinical insights from genetics of insomnia symptoms. Nat Genet. 2019 03; 51(3):387-393. PMID: 30804566.
  22. Stenvers DJ, Scheer FAJL, Schrauwen P, la Fleur SE, Kalsbeek A. Circadian clocks and insulin resistance. Nat Rev Endocrinol. 2019 02; 15(2):75-89. PMID: 30531917.
    Citations:    Fields:    
  23. Xiao Q, Garaulet M, Scheer FAJL. Meal timing and obesity: interactions with macronutrient intake and chronotype. Int J Obes (Lond). 2019 09; 43(9):1701-1711. PMID: 30705391.
    Citations:    Fields:    
  24. Chellappa SL, Morris CJ, Scheer FAJL. Effects of circadian misalignment on cognition in chronic shift workers. Sci Rep. 2019 01 24; 9(1):699. PMID: 30679522.
    Citations:    Fields:    
  25. Scheer FAJL, Chellappa SL, Hu K, Shea SA. Impact of mental stress, the circadian system and their interaction on human cardiovascular function. Psychoneuroendocrinology. 2019 05; 103:125-129. PMID: 30682628.
    Citations:    Fields:    
  26. Qian J, Morris CJ, Caputo R, Garaulet M, Scheer FAJL. Ghrelin is impacted by the endogenous circadian system and by circadian misalignment in humans. Int J Obes (Lond). 2019 08; 43(8):1644-1649. PMID: 30232416.
    Citations:    Fields:    
  27. Wefers J, van Moorsel D, Hansen J, Connell NJ, Havekes B, Hoeks J, van Marken Lichtenbelt WD, Duez H, Phielix E, Kalsbeek A, Boekschoten MV, Hooiveld GJ, Hesselink MKC, Kersten S, Staels B, Scheer FAJL, Schrauwen P. Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):7789-7794. PMID: 29987027.
    Citations: 1     Fields:    Translation:Humans
  28. Qian J, Dalla Man C, Morris CJ, Cobelli C, Scheer FAJL. Differential effects of the circadian system and circadian misalignment on insulin sensitivity and insulin secretion in humans. Diabetes Obes Metab. 2018 10; 20(10):2481-2485. PMID: 29862620.
    Citations:    Fields:    
  29. Kolbe I, Carrasco-Benso MP, López-Mínguez J, Luján J, Scheer FAJL, Oster H, Garaulet M. Circadian period of luciferase expression shortens with age in human mature adipocytes from obese patients. FASEB J. 2019 01; 33(1):175-180. PMID: 29965796.
    Citations:    Fields:    
  30. Li P, Yu L, Lim ASP, Buchman AS, Scheer FAJL, Shea SA, Schneider JA, Bennett DA, Hu K. Fractal regulation and incident Alzheimer's disease in elderly individuals. Alzheimers Dement. 2018 09; 14(9):1114-1125. PMID: 29733807.
    Citations:    Fields:    
  31. Lopez-Minguez J, Dashti HS, Madrid-Valero JJ, Madrid JA, Saxena R, Scheer FAJL, Ordoñana JR, Garaulet M. Heritability of the timing of food intake. Clin Nutr. 2019 04; 38(2):767-773. PMID: 29571565.
    Citations:    Fields:    
  32. Chellappa SL, Morris CJ, Scheer FAJL. Daily circadian misalignment impairs human cognitive performance task-dependently. Sci Rep. 2018 02 14; 8(1):3041. PMID: 29445188.
    Citations: 2     Fields:    
  33. Vetter C, Dashti HS, Lane JM, Anderson SG, Schernhammer ES, Rutter MK, Saxena R, Scheer FAJL. Night Shift Work, Genetic Risk, and Type 2 Diabetes in the UK Biobank. Diabetes Care. 2018 04; 41(4):762-769. PMID: 29440150.
    Citations: 1     Fields:    Translation:Humans
  34. Williams JS, Autori PJ, Kidd SK, Piazza G, Connors MC, Czeisler CA, Scheuermaier KD, Duffy J, Klerman EB, Scheer FA, Kozak M, Driscoll SM, Goldhaber SZ. Heparin-Induced Thrombocytopenia in Healthy Individuals with Continuous Heparin Infusion. TH Open. 2018 Jan; 2(1):e49-e53. PMID: 31249929.
  35. Vera B, Dashti HS, Gómez-Abellán P, Hernández-Martínez AM, Esteban A, Scheer FAJL, Saxena R, Garaulet M. Modifiable lifestyle behaviors, but not a genetic risk score, associate with metabolic syndrome in evening chronotypes. Sci Rep. 2018 01 17; 8(1):945. PMID: 29343740.
    Citations:    Fields:    Translation:Humans
  36. Collado MC, Engen PA, Bandín C, Cabrera-Rubio R, Voigt RM, Green SJ, Naqib A, Keshavarzian A, Scheer FAJL, Garaulet M. Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study. FASEB J. 2018 04; 32(4):2060-2072. PMID: 29233857.
    Citations: 1     Fields:    Translation:Humans
  37. Joustra SD, Gu C, Rohling JHT, Pickering L, Klose M, Hu K, Scheer FA, Feldt-Rasmussen U, Jennum PJ, Pereira AM, Biermasz NR, Meijer JH. Decrease in scale invariance of activity fluctuations with aging and in patients with suprasellar tumors. Chronobiol Int. 2018 03; 35(3):368-377. PMID: 29182371.
    Citations:    Fields:    
  38. McHill AW, Phillips AJ, Czeisler CA, Keating L, Yee K, Barger LK, Garaulet M, Scheer FA, Klerman EB. Later circadian timing of food intake is associated with increased body fat. Am J Clin Nutr. 2017 Nov; 106(5):1213-1219. PMID: 28877894.
    Citations: 14     Fields:    Translation:Humans
  39. Dashti HS, Follis JL, Smith CE, Tanaka T, Garaulet M, Gottlieb DJ, Hruby A, Jacques PF, Kiefte-de Jong JC, Lamon-Fava S, Scheer FAJL, Bartz TM, Kovanen L, Wojczynski MK, Frazier-Wood AC, Ahluwalia TS, Perälä MM, Jonsson A, Muka T, Kalafati IP, Mikkilä V, Ordovás JM. Erratum. Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits. Diabetes Care 2015;38:1456-1466. Diabetes Care. 2017 10; 40(10):1420. PMID: 28842526.
    Citations:    Fields:    
  40. Lo MT, Bandin C, Yang HW, Scheer FAJL, Hu K, Garaulet M. CLOCK 3111T/C genetic variant influences the daily rhythm of autonomic nervous function: relevance to body weight control. Int J Obes (Lond). 2018 02; 42(2):190-197. PMID: 28736443.
    Citations:    Fields:    
  41. Vetter C, Scheer FAJL. Circadian Biology: Uncoupling Human Body Clocks by Food Timing. Curr Biol. 2017 07 10; 27(13):R656-R658. PMID: 28697366.
    Citations:    Fields:    
  42. Li P, Morris CJ, Patxot M, Yugay T, Mistretta J, Purvis TE, Scheer FAJL, Hu K. Reduced Tolerance to Night Shift in Chronic Shift Workers: Insight From Fractal Regulation. Sleep. 2017 07 01; 40(7). PMID: 28838129.
    Citations:    Fields:    Translation:Humans
  43. Lopez-Minguez J, Saxena R, Bandín C, Scheer FA, Garaulet M. Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: A randomized, cross-over study. Clin Nutr. 2018 08; 37(4):1133-1140. PMID: 28455106.
    Citations: 3     Fields:    
  44. Tucker MA, Morris CJ, Morgan A, Yang J, Myers S, Pierce JG, Stickgold R, Scheer FAJL. The Relative Impact of Sleep and Circadian Drive on Motor Skill Acquisition and Memory Consolidation. Sleep. 2017 04 01; 40(4). PMID: 28460138.
    Citations: 2     Fields:    Translation:Humans
  45. Morris CJ, Purvis TE, Mistretta J, Hu K, Scheer FAJL. Circadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers. J Biol Rhythms. 2017 04; 32(2):154-164. PMID: 28347188.
    Citations: 5     Fields:    Translation:Humans
  46. Ohayon M, Wickwire EM, Hirshkowitz M, Albert SM, Avidan A, Daly FJ, Dauvilliers Y, Ferri R, Fung C, Gozal D, Hazen N, Krystal A, Lichstein K, Mallampalli M, Plazzi G, Rawding R, Scheer FA, Somers V, Vitiello MV. National Sleep Foundation's sleep quality recommendations: first report. Sleep Health. 2017 02; 3(1):6-19. PMID: 28346153.
    Citations: 16     Fields:    Translation:Humans
  47. Lane JM, Liang J, Vlasac I, Anderson SG, Bechtold DA, Bowden J, Emsley R, Gill S, Little MA, Luik AI, Loudon A, Scheer FA, Purcell SM, Kyle SD, Lawlor DA, Zhu X, Redline S, Ray DW, Rutter MK, Saxena R. Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits. Nat Genet. 2017 Feb; 49(2):274-281. PMID: 27992416.
    Citations: 17     Fields:    Translation:Humans
  48. Scheer F, Spunar P, Wiggermann P, Wissgott C, Andresen R. Mesenteric Panniculitis (MP) in CT - A Predictor of Malignancy? Rofo. 2016 Oct; 188(10):926-32. PMID: 27529397.
    Citations: 3     Fields:    Translation:Humans
  49. van Moorsel D, Hansen J, Havekes B, Scheer FAJL, Jörgensen JA, Hoeks J, Schrauwen-Hinderling VB, Duez H, Lefebvre P, Schaper NC, Hesselink MKC, Staels B, Schrauwen P. Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity. Mol Metab. 2016 Aug; 5(8):635-645. PMID: 27656401.
    Citations: 7     Fields:    
  50. Hu K, Riemersma-van der Lek RF, Patxot M, Li P, Shea SA, Scheer FA, Van Someren EJ. Progression of Dementia Assessed by Temporal Correlations of Physical Activity: Results From a 3.5-Year, Longitudinal Randomized Controlled Trial. Sci Rep. 2016 06 13; 6:27742. PMID: 27292543.
    Citations: 2     Fields:    Translation:Humans
  51. Carrasco-Benso MP, Rivero-Gutierrez B, Lopez-Minguez J, Anzola A, Diez-Noguera A, Madrid JA, Lujan JA, Martínez-Augustin O, Scheer FA, Garaulet M. Human adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity. FASEB J. 2016 09; 30(9):3117-23. PMID: 27256623.
    Citations: 6     Fields:    Translation:HumansCells
  52. Chang AM, Bjonnes AC, Aeschbach D, Buxton OM, Gooley JJ, Anderson C, Van Reen E, Cain SW, Czeisler CA, Duffy JF, Lockley SW, Shea SA, Scheer FA, Saxena R. Circadian gene variants influence sleep and the sleep electroencephalogram in humans. Chronobiol Int. 2016; 33(5):561-73. PMID: 27089043.
    Citations:    Fields:    Translation:Humans
  53. Qian J, Scheer FAJL. Circadian System and Glucose Metabolism: Implications for Physiology and Disease. Trends Endocrinol Metab. 2016 05; 27(5):282-293. PMID: 27079518.
    Citations: 25     Fields:    Translation:HumansAnimals
  54. Johnston JD, Ordovás JM, Scheer FA, Turek FW. Circadian Rhythms, Metabolism, and Chrononutrition in Rodents and Humans. Adv Nutr. 2016 Mar; 7(2):399-406. PMID: 26980824.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  55. Lane JM, Vlasac I, Anderson SG, Kyle SD, Dixon WG, Bechtold DA, Gill S, Little MA, Luik A, Loudon A, Emsley R, Scheer FA, Lawlor DA, Redline S, Ray DW, Rutter MK, Saxena R. Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank. Nat Commun. 2016 Mar 09; 7:10889. PMID: 26955885.
    Citations: 27     Fields:    Translation:Humans
  56. Scheer FA. Hungry for Sleep: A Role for Endocannabinoids? Sleep. 2016 Mar 01; 39(3):495-6. PMID: 26856900.
    Citations:    Fields:    
  57. Ruiz-Lozano T, Vidal J, de Hollanda A, Scheer FAJL, Garaulet M, Izquierdo-Pulido M. Timing of food intake is associated with weight loss evolution in severe obese patients after bariatric surgery. Clin Nutr. 2016 12; 35(6):1308-1314. PMID: 26948400.
    Citations: 12     Fields:    Translation:Humans
  58. Lane JM, Chang AM, Bjonnes AC, Aeschbach D, Anderson C, Cade BE, Cain SW, Czeisler CA, Gharib SA, Gooley JJ, Gottlieb DJ, Grant SF, Klerman EB, Lauderdale DS, Lockley SW, Munch M, Patel S, Punjabi NM, Rajaratnam SM, Rueger M, St Hilaire MA, Santhi N, Scheuermaier K, Van Reen E, Zee PC, Shea SA, Duffy JF, Buxton OM, Redline S, Scheer FA, Saxena R. Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology. Diabetes. 2016 06; 65(6):1741-51. PMID: 26868293.
    Citations: 11     Fields:    Translation:Humans
  59. Dashti HS, Zuurbier LA, de Jonge E, Voortman T, Jacques PF, Lamon-Fava S, Scheer FA, Kiefte-De Jong JC, Hofman A, Ordovás JM, Franco OH, Tiemeier H. Actigraphic sleep fragmentation, efficiency and duration associate with dietary intake in the Rotterdam Study. J Sleep Res. 2016 08; 25(4):404-11. PMID: 26857552.
    Citations: 1     Fields:    Translation:Humans
  60. Morris CJ, Purvis TE, Hu K, Scheer FA. Circadian misalignment increases cardiovascular disease risk factors in humans. Proc Natl Acad Sci U S A. 2016 Mar 08; 113(10):E1402-11. PMID: 26858430.
    Citations: 39     Fields:    Translation:Humans
  61. Morris CJ, Purvis TE, Mistretta J, Scheer FA. Effects of the Internal Circadian System and Circadian Misalignment on Glucose Tolerance in Chronic Shift Workers. J Clin Endocrinol Metab. 2016 Mar; 101(3):1066-74. PMID: 26771705.
    Citations: 21     Fields:    Translation:HumansCells
  62. Arble DM, Bass J, Behn CD, Butler MP, Challet E, Czeisler C, Depner CM, Elmquist J, Franken P, Grandner MA, Hanlon EC, Keene AC, Joyner MJ, Karatsoreos I, Kern PA, Klein S, Morris CJ, Pack AI, Panda S, Ptacek LJ, Punjabi NM, Sassone-Corsi P, Scheer FA, Saxena R, Seaquest ER, Thimgan MS, Van Cauter E, Wright KP. Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions. Sleep. 2015 Dec 01; 38(12):1849-60. PMID: 26564131.
    Citations: 13     Fields:    Translation:HumansAnimals
  63. Dashti HS, Scheer FA, Jacques PF, Lamon-Fava S, Ordovás JM. Short sleep duration and dietary intake: epidemiologic evidence, mechanisms, and health implications. Adv Nutr. 2015 Nov; 6(6):648-59. PMID: 26567190.
    Citations: 25     Fields:    Translation:HumansPHPublic Health
  64. Morris CJ, Garcia JI, Myers S, Yang JN, Trienekens N, Scheer FA. The Human Circadian System Has a Dominating Role in Causing the Morning/Evening Difference in Diet-Induced Thermogenesis. Obesity (Silver Spring). 2015 Oct; 23(10):2053-8. PMID: 26414564.
    Citations: 14     Fields:    Translation:Humans
  65. Garaulet M, Gómez-Abellán P, Rubio-Sastre P, Madrid JA, Saxena R, Scheer FA. Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans. Metabolism. 2015 Dec; 64(12):1650-7. PMID: 26440713.
    Citations: 11     Fields:    Translation:Humans
  66. Dashti HS, Follis JL, Smith CE, Tanaka T, Garaulet M, Gottlieb DJ, Hruby A, Jacques PF, Kiefte-de Jong JC, Lamon-Fava S, Scheer FA, Bartz TM, Kovanen L, Wojczynski MK, Frazier-Wood AC, Ahluwalia TS, Perälä MM, Jonsson A, Muka T, Kalafati IP, Mikkilä V, Ordovás JM. Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits. Diabetes Care. 2015 Aug; 38(8):1456-66. PMID: 26084345.
    Citations: 6     Fields:    Translation:Humans
  67. Dashti HS, Aslibekyan S, Scheer FA, Smith CE, Lamon-Fava S, Jacques P, Lai CQ, Tucker KL, Arnett DK, Ordovás JM. Clock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature. Am J Hypertens. 2016 Jan; 29(1):132-40. PMID: 26045533.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  68. Morris CJ, Yang JN, Garcia JI, Myers S, Bozzi I, Wang W, Buxton OM, Shea SA, Scheer FA. Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans. Proc Natl Acad Sci U S A. 2015 Apr 28; 112(17):E2225-34. PMID: 25870289.
    Citations: 40     Fields:    Translation:HumansCellsCTClinical Trials
  69. Burke TM, Scheer FAJL, Ronda JM, Czeisler CA, Wright KP. Sleep inertia, sleep homeostatic and circadian influences on higher-order cognitive functions. J Sleep Res. 2015 Aug; 24(4):364-371. PMID: 25773686.
    Citations: 12     Fields:    Translation:Humans
  70. Gu C, Coomans CP, Hu K, Scheer FA, Stanley HE, Meijer JH. Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2320-4. PMID: 25675516.
    Citations: 9     Fields:    Translation:HumansAnimals
  71. Dashti HS, Follis JL, Smith CE, Tanaka T, Cade BE, Gottlieb DJ, Hruby A, Jacques PF, Lamon-Fava S, Richardson K, Saxena R, Scheer FA, Kovanen L, Bartz TM, Perälä MM, Jonsson A, Frazier-Wood AC, Kalafati IP, Mikkilä V, Partonen T, Lemaitre RN, Lahti J, Hernandez DG, Toft U, Johnson WC, Kanoni S, Raitakari OT, Perola M, Psaty BM, Ferrucci L, Grarup N, Highland HM, Rallidis L, Kähönen M, Havulinna AS, Siscovick DS, Räikkönen K, Jørgensen T, Rotter JI, Deloukas P, Viikari JS, Mozaffarian D, Linneberg A, Seppälä I, Hansen T, Salomaa V, Gharib SA, Eriksson JG, Bandinelli S, Pedersen O, Rich SS, Dedoussis G, Lehtimäki T, Ordovás JM. Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants. Am J Clin Nutr. 2015 Jan; 101(1):135-43. PMID: 25527757.
    Citations: 15     Fields:    Translation:HumansCTClinical Trials
  72. Mattson MP, Allison DB, Fontana L, Harvie M, Longo VD, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FA, Seyfried TN, Varady KA, Panda S. Meal frequency and timing in health and disease. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16647-53. PMID: 25404320.
    Citations: 57     Fields:    Translation:Humans
  73. Rahman SA, Castanon-Cervantes O, Scheer FA, Shea SA, Czeisler CA, Davidson AJ, Lockley SW. Endogenous circadian regulation of pro-inflammatory cytokines and chemokines in the presence of bacterial lipopolysaccharide in humans. Brain Behav Immun. 2015 Jul; 47:4-13. PMID: 25452149.
    Citations: 11     Fields:    Translation:Humans
  74. Bandín C, Scheer FA, Luque AJ, Ávila-Gandía V, Zamora S, Madrid JA, Gómez-Abellán P, Garaulet M. Meal timing affects glucose tolerance, substrate oxidation and circadian-related variables: A randomized, crossover trial. Int J Obes (Lond). 2015 May; 39(5):828-33. PMID: 25311083.
    Citations: 20     Fields:    Translation:HumansCells
  75. Rubio-Sastre P, Scheer FA, Gómez-Abellán P, Madrid JA, Garaulet M. Acute melatonin administration in humans impairs glucose tolerance in both the morning and evening. Sleep. 2014 Oct 01; 37(10):1715-9. PMID: 25197811.
    Citations: 27     Fields:    Translation:Humans
  76. Nedeltcheva AV, Scheer FA. Metabolic effects of sleep disruption, links to obesity and diabetes. Curr Opin Endocrinol Diabetes Obes. 2014 Aug; 21(4):293-8. PMID: 24937041.
    Citations: 29     Fields:    Translation:Humans
  77. Hsieh WH, Escobar C, Yugay T, Lo MT, Pittman-Polletta B, Salgado-Delgado R, Scheer FA, Shea SA, Buijs RM, Hu K. Simulated shift work in rats perturbs multiscale regulation of locomotor activity. J R Soc Interface. 2014 Jul 06; 11(96). PMID: 24829282.
    Citations: 10     Fields:    Translation:Animals
  78. Buijs FN, Cazarez F, Basualdo MC, Scheer FA, Perusquía M, Centurion D, Buijs RM. The suprachiasmatic nucleus is part of a neural feedback circuit adapting blood pressure response. Neuroscience. 2014 Apr 25; 266:197-207. PMID: 24583038.
    Citations: 4     Fields:    Translation:Animals
  79. Tare A, Lane JM, Cade BE, Grant SF, Chen TH, Punjabi NM, Lauderdale DS, Zee PC, Gharib SA, Gottlieb DJ, Scheer FA, Redline S, Saxena R. Sleep duration does not mediate or modify association of common genetic variants with type 2 diabetes. Diabetologia. 2014 Feb; 57(2):339-46. PMID: 24280871.
    Citations: 3     Fields:    Translation:Humans
  80. Scheer FA, Shea SA. Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle. Blood. 2014 Jan 23; 123(4):590-3. PMID: 24200683.
    Citations: 25     Fields:    Translation:Humans
  81. Chang AM, Scheer FA, Czeisler CA, Aeschbach D. Direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans depend on prior light history. Sleep. 2013 Aug 01; 36(8):1239-46. PMID: 23904684.
    Citations: 8     Fields:    Translation:Humans
  82. Lane JM, Tare A, Cade BE, Chen TH, Punjabi NM, Gottlieb DJ, Scheer FA, Redline S, Saxena R. Common variants in CLOCK are not associated with measures of sleep duration in people of european ancestry from the sleep heart health study. Biol Psychiatry. 2013 Dec 15; 74(12):e33-5. PMID: 23871470.
    Citations: 4     Fields:    Translation:Humans
  83. Pittman-Polletta BR, Scheer FA, Butler MP, Shea SA, Hu K. The role of the circadian system in fractal neurophysiological control. Biol Rev Camb Philos Soc. 2013 Nov; 88(4):873-94. PMID: 23573942.
    Citations: 14     Fields:    Translation:Animals
  84. Morris CJ, Hastings JA, Boyd K, Krainski F, Perhonen MA, Scheer FA, Levine BD. Day/night variability in blood pressure: influence of posture and physical activity. Am J Hypertens. 2013 Jun; 26(6):822-8. PMID: 23535155.
    Citations: 2     Fields:    Translation:Humans
  85. Scheer FA, Morris CJ, Shea SA. The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors. Obesity (Silver Spring). 2013 Mar; 21(3):421-3. PMID: 23456944.
    Citations: 29     Fields:    Translation:Humans
  86. Garaulet M, Gómez-Abellán P, Alburquerque-Béjar JJ, Lee YC, Ordovás JM, Scheer FA. Timing of food intake predicts weight loss effectiveness. Int J Obes (Lond). 2013 Apr; 37(4):604-11. PMID: 23357955.
    Citations: 84     Fields:    Translation:Humans
  87. Wu YH, Ursinus J, Zhou JN, Scheer FA, Ai-Min B, Jockers R, van Heerikhuize J, Swaab DF. Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression. J Affect Disord. 2013 Jun; 148(2-3):357-67. PMID: 23357659.
    Citations: 18     Fields:    Translation:Humans
  88. Hu K, Harper DG, Shea SA, Stopa EG, Scheer FA. Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia. Sci Rep. 2013; 3:2229. PMID: 23863985.
    Citations: 12     Fields:    Translation:HumansCells
  89. Hu K, Meijer JH, Shea SA, vanderLeest HT, Pittman-Polletta B, Houben T, van Oosterhout F, Deboer T, Scheer FA. Fractal patterns of neural activity exist within the suprachiasmatic nucleus and require extrinsic network interactions. PLoS One. 2012; 7(11):e48927. PMID: 23185285.
    Citations: 11     Fields:    Translation:AnimalsCells
  90. Scheer FA, Morris CJ, Garcia JI, Smales C, Kelly EE, Marks J, Malhotra A, Shea SA. Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial. Sleep. 2012 Oct 01; 35(10):1395-402. PMID: 23024438.
    Citations: 10     Fields:    Translation:Humans
  91. Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, Jain MK. Klf15 orchestrates circadian nitrogen homeostasis. Cell Metab. 2012 Mar 07; 15(3):311-23. PMID: 22405069.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  92. Morris CJ, Yang JN, Scheer FAJL. The impact of the circadian timing system on cardiovascular and metabolic function. Prog Brain Res. 2012; 199:337-358. PMID: 22877674.
    Citations: 39     Fields:    Translation:HumansAnimals
  93. Morris CJ, Aeschbach D, Scheer FA. Circadian system, sleep and endocrinology. Mol Cell Endocrinol. 2012 Feb 05; 349(1):91-104. PMID: 21939733.
    Citations: 60     Fields:    Translation:HumansAnimals
  94. Scheer FA, Michelson AD, Frelinger AL, Evoniuk H, Kelly EE, McCarthy M, Doamekpor LA, Barnard MR, Shea SA. The human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors. PLoS One. 2011; 6(9):e24549. PMID: 21931750.
    Citations: 23     Fields:    Translation:Humans
  95. Shea SA, Hilton MF, Hu K, Scheer FA. Existence of an endogenous circadian blood pressure rhythm in humans that peaks in the evening. Circ Res. 2011 Apr 15; 108(8):980-4. PMID: 21474818.
    Citations: 33     Fields:    Translation:Humans
  96. Kalsbeek A, Scheer FA, Perreau-Lenz S, La Fleur SE, Yi CX, Fliers E, Buijs RM. Circadian disruption and SCN control of energy metabolism. FEBS Lett. 2011 May 20; 585(10):1412-26. PMID: 21414317.
    Citations: 18     Fields:    Translation:HumansAnimals
  97. Hu K, Scheer FA, Laker M, Smales C, Shea SA. Endogenous circadian rhythm in vasovagal response to head-up tilt. Circulation. 2011 Mar 08; 123(9):961-70. PMID: 21339480.
    Citations: 19     Fields:    Translation:Humans
  98. Chang AM, Scheer FA, Czeisler CA. The human circadian system adapts to prior photic history. J Physiol. 2011 Mar 01; 589(Pt 5):1095-102. PMID: 21224217.
    Citations: 34     Fields:    Translation:Humans
  99. Scheer FA, Hu K, Evoniuk H, Kelly EE, Malhotra A, Hilton MF, Shea SA. Impact of the human circadian system, exercise, and their interaction on cardiovascular function. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20541-6. PMID: 21059915.
    Citations: 67     Fields:    Translation:Humans
  100. Scheer FA, Chan JL, Fargnoli J, Chamberland J, Arampatzi K, Shea SA, Blackburn GL, Mantzoros CS. Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions. Diabetologia. 2010 Nov; 53(11):2401-5. PMID: 20703446.
    Citations: 22     Fields:    Translation:Humans
  101. Jung CM, Khalsa SB, Scheer FA, Cajochen C, Lockley SW, Czeisler CA, Wright KP. Acute effects of bright light exposure on cortisol levels. J Biol Rhythms. 2010 Jun; 25(3):208-16. PMID: 20484692.
    Citations: 26     Fields:    Translation:Humans
  102. Rüger M, Scheer FA. Effects of circadian disruption on the cardiometabolic system. Rev Endocr Metab Disord. 2009 Dec; 10(4):245-60. PMID: 19784781.
    Citations: 42     Fields:    Translation:HumansAnimals
  103. Pavlova MK, Shea SA, Scheer FA, Bromfield EB. Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy? Epilepsy Behav. 2009 Nov; 16(3):461-7. PMID: 19786369.
    Citations: 8     Fields:    Translation:Humans
  104. Litinski M, Scheer FA, Shea SA. Influence of the Circadian System on Disease Severity. Sleep Med Clin. 2009 Jun 01; 4(2):143-163. PMID: 20161149.
    Citations: 13     Fields:    
  105. Scheer FA, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4453-8. PMID: 19255424.
    Citations: 419     Fields:    Translation:Humans
  106. Hu K, Van Someren EJ, Shea SA, Scheer FA. Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2490-4. PMID: 19202078.
    Citations: 54     Fields:    Translation:Humans
  107. Scheer FA, Shea TJ, Hilton MF, Shea SA. An endogenous circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night. J Biol Rhythms. 2008 Aug; 23(4):353-61. PMID: 18663242.
    Citations: 31     Fields:    Translation:Humans
  108. Hu K, Scheer FA, Buijs RM, Shea SA. The circadian pacemaker generates similar circadian rhythms in the fractal structure of heart rate in humans and rats. Cardiovasc Res. 2008 Oct 01; 80(1):62-8. PMID: 18539630.
    Citations: 11     Fields:    Translation:HumansAnimals
  109. Hu K, Scheer FA, Buijs RM, Shea SA. The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours. J Biol Rhythms. 2008 Jun; 23(3):265-73. PMID: 18487418.
    Citations: 13     Fields:    Translation:Animals
  110. Hu K, Scheer FA, Ivanov PCh, Buijs RM, Shea SA. The suprachiasmatic nucleus functions beyond circadian rhythm generation. Neuroscience. 2007 Nov 09; 149(3):508-17. PMID: 17920204.
    Citations: 30     Fields:    Translation:HumansAnimals
  111. Scheer FA, Wright KP, Kronauer RE, Czeisler CA. Plasticity of the intrinsic period of the human circadian timing system. PLoS One. 2007 Aug 08; 2(8):e721. PMID: 17684566.
    Citations: 30     Fields:    Translation:Humans
  112. Scheer FA, Stone PH, Shea SA. Decreased sleep in heart failure: are medications to blame? Arch Intern Med. 2007 May 28; 167(10):1098-9; author reply 1099-100. PMID: 17533214.
    Citations: 3     Fields:    Translation:Humans
  113. Shea SA, Hu K, Buijs RM, Scheer FAJL. Lesioning the suprachiasmatic nucleus abolishes ultradian rhythms of locomotor activity in rats. Sleep. 2007; 30:A58.
  114. Scheer FAJL, Hilton MF, Benjamin T, Barb D, Evoniuk H, Mantzoros CS, Shea SA. . Desynchrony between sleep-wake cycle and circadian cycle leads to suppressed plasma leptin; potential relevance for shift workers. Sleep. 2007; 30:A61.
  115. Hu K, Scheer FAJL, Buijs RM, Shea SA. The circadian pacemaker contributes to intrinsic scale-invariant patterns of cardiac dynamics across a wide range of time scales – Spanning 4-24 Hours. Sleep. 2007; 30:A58.
  116. Hu K, Scheer FAJL, Buijs RM, Shea SA. Effect of lesioning the suprachiasmatic nucleus on fractal pattern of heart rate fluctuations. Sleep. 2007; 30:A64.
  117. Shea SA, Scheer FAJL, Hilton MF. Predicting the daily pattern of asthma severity based on the relative contribution of the circadian timing system, the sleep-wake cycle and the environment. Sleep. 2007; 30:A65.
  118. Scheer FAJL, Hahn M, Doamekpor LA, Evoniuk H, Kelly K, Laker MD, Shea SA. Lack of endogenous circadian rhythm of platelet aggregability. Sleep. 2007; 30:A64.
  119. Kalsbeek A, Palm IF, La Fleur SE, Scheer FA, Perreau-Lenz S, Ruiter M, Kreier F, Cailotto C, Buijs RM. SCN outputs and the hypothalamic balance of life. J Biol Rhythms. 2006 Dec; 21(6):458-69. PMID: 17107936.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  120. Lockley SW, Evans EE, Scheer FA, Brainard GC, Czeisler CA, Aeschbach D. Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans. Sleep. 2006 Feb; 29(2):161-8. PMID: 16494083.
    Citations: 109     Fields:    Translation:Humans
  121. Scheer FA, Zeitzer JM, Ayas NT, Brown R, Czeisler CA, Shea SA. Reduced sleep efficiency in cervical spinal cord injury; association with abolished night time melatonin secretion. Spinal Cord. 2006 Feb; 44(2):78-81. PMID: 16130027.
    Citations: 20     Fields:    Translation:Humans
  122. Frank A.J.L. Scheer, Thomas J. Shea, Heather L. Evoniuk, Michael F. Hilton. Circadian Rhythm in Degree of Sleep Inertia Following Awakening. J Sleep Res. 2006; 15(1):55.
  123. Buijs RM, Scheer FA, Kreier F, Yi C, Bos N, Goncharuk VD, Kalsbeek A. Organization of circadian functions: interaction with the body. Prog Brain Res. 2006; 153:341-60. PMID: 16876585.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  124. Shea TJ, Hilton MF, Evoniuk H, Scheer FAJL. Circadian effect on degree of sleep inertia present after awakening. Sleep. 2006; A67.
  125. Evoniuk HL, Scheer FAJL, Hilton MF, Schory KE, Shea SA. Challenges to sleep in asthma studied under baseline conditions, reduced homeostatic sleep drive, and adverse circadian phase for sleep. Sleep. 2006.
  126. Frank A.J.L. Scheer. Suprachiasmatic nucleus, environmental light, and metabolic state interact in the regulation of body temperature. J Sleep Res. 2006; 15(1):20.
  127. Scheer FAJL. Suprachiasmatic nucleus, environmental light, and metabolic state interact in the regulation of body temperature. J Sleep Res. 2006; 20.
  128. Thomas J Shea, Michael F Hilton, Heather L Evoniuk, Frank AJL Scheer. Circadian Effect on Degree of Sleep Inertia Present After Awakening. Sleep. 2006; 29:A67.
  129. Kun Hu, Frank A.J.L. Scheer, Plamen Ch. Ivanov, Ruud M. Buijs, Steven A. Shea. Intrinsic scale-invariant patterns of locomotor activity: role of the circadian pacemaker across a wide range of time scales – spanning 4-24 hours. Sleep. 2006; 29:A64.
  130. Scheer FA. Potential use of melatonin as adjunct antihypertensive therapy. Am J Hypertens. 2005 Dec; 18(12 Pt 1):1619-20. PMID: 16364835.
    Citations: 3     Fields:    Translation:Humans
  131. Scheer FA, Czeisler CA. Melatonin, sleep, and circadian rhythms. Sleep Med Rev. 2005 Feb; 9(1):5-9. PMID: 15649734.
    Citations: 18     Fields:    Translation:HumansAnimals
  132. Shea SA, Scheer FAJL, Evoniuk HL, Shiels SA, Malhotra A, Sugarbaker R, Ayers RT, Okruch A, Weiner M, Rinzler S, Massaro AF, Hilton MF. Role of the endogenous circadian system in bronchoconstriction, airway inflammation and rescue medication use in asthma. Chronobiology Int. 2005.
  133. Scheer FAJL, Cajochen C, Turek FW, Czeisler CA. . Melatonin in the regulation of sleep and circadian rhythms. Kryger MH, Roth T, Dement WC (ed). Principles and Practice of Sleep Medicine. 2005; 395-404.
  134. Scheer FAJL, Wright Jr. KP, Gronfier C, Kronauer RE, Czeisler CA. Human circadian period is influenced by entrainment to non-24 hour schedules. Sleep. 2005; 28:A72.
  135. Scheer FA, Pirovano C, Van Someren EJ, Buijs RM. Environmental light and suprachiasmatic nucleus interact in the regulation of body temperature. Neuroscience. 2005; 132(2):465-77. PMID: 15802197.
    Citations: 15     Fields:    Translation:Animals
  136. Shea SA, Hilton MF, Malhotra A, Evoniuk H, Shiels S, Sugarbaker R, Ayers RT, Weiner M, Massaro AF, Scheer FAJL. . Interaction between effects of the circadian pacemaker and behavioral sleep-wake cycle on pulmonary function in asthma. Sleep. 2005; 28:A73.
  137. Jung CM, Khalsa S, Scheer FA, Czeisler CA, Wright KP. Acute effects of bright light exposure on nighttime cortisol levels in humans. Sleep. 2005; 28:A59.
  138. Evoniuk H, Hilton MF, Scheer FAJL, Malhotra A, Shiels S, Sugarbaker R, Weiner M, Ayers RT, Massaro AF, Shea SA. Effects of endogenous circadian rhythms, sleep and sleep deprivation on airway function in asthma explored with a constant routine protocol. Sleep. 2005; 28:A71.
  139. Scheer FA, Van Doornen LJ, Buijs RM. Light and diurnal cycle affect autonomic cardiac balance in human; possible role for the biological clock. Auton Neurosci. 2004 Jan 30; 110(1):44-8. PMID: 14766324.
    Citations: 8     Fields:    Translation:Humans
  140. Scheer FA, Van Montfrans GA, van Someren EJ, Mairuhu G, Buijs RM. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension. 2004 Feb; 43(2):192-7. PMID: 14732734.
    Citations: 67     Fields:    Translation:HumansCTClinical Trials
  141. Scheer FAJL, Van Montfrans GA, Buijs RM. . Chronic, but not acute, nighttime melatonin administration improves sleep quality in hypertensive patients. Sleep. 2004; 27:A329.
  142. Shea SA, Hilton MF, Scheer FA, Ayers R, Evoniuk HL, Shiels SA, Sugarbaker RJ, Malhotra A, Massaro AF. An endogenous circadian rhythm in bronchodilator rescue medication use in asthma. Sleep. 2004; 27:A81.
  143. Scheer FA, Kalsbeek A, Buijs RM. Cardiovascular control by the suprachiasmatic nucleus: neural and neuroendocrine mechanisms in human and rat. Biol Chem. 2003 May; 384(5):697-709. PMID: 12817466.
    Citations: 32     Fields:    Translation:HumansAnimals
  144. Scheer FA, Van Paassen B, Van Montfrans GA, Fliers E, Van Someren EJ, Van Heerikhuize JJ, Buijs RM. Human basal cortisol levels are increased in hospital compared to home setting. Neurosci Lett. 2002 Nov 22; 333(2):79-82. PMID: 12419485.
    Citations: 2     Fields:    Translation:Humans
  145. Scheer FA, Ter Horst GJ, van Der Vliet J, Buijs RM. Physiological and anatomic evidence for regulation of the heart by suprachiasmatic nucleus in rats. Am J Physiol Heart Circ Physiol. 2001 Mar; 280(3):H1391-9. PMID: 11179089.
    Citations: 36     Fields:    Translation:AnimalsCells
  146. Buijs RM, Hermes MLHJ, Dai J, Scheer FAJL, Kalsbeek A. Circadian organization of the autonomic Nervous system. Ter Horst GJ (ed). The Nervous System and the Heart. 2000; 117-157.
  147. Scheer FA, Buijs RM. Light affects morning salivary cortisol in humans. J Clin Endocrinol Metab. 1999 Sep; 84(9):3395-8. PMID: 10487717.
    Citations: 27     Fields:    Translation:Humans
  148. Scheer FA, van Doornen LJ, Buijs RM. Light and diurnal cycle affect human heart rate: possible role for the circadian pacemaker. J Biol Rhythms. 1999 Jun; 14(3):202-12. PMID: 10452332.
    Citations: 16     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.