Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Lawrence C. Madoff, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56AI038424 (MADOFF, LAWRENCE C.) Mar 1, 1997 - Jun 30, 2008
    Group B Streptococcal Surface Proteins in Immune Evasion
    Role: Principal Investigator
  2. R01AI038424 (MADOFF, LAWRENCE C.) Mar 1, 1997 - Jun 30, 2006
    Group B Streptococcal Surface Proteins Immune Evasion
    Role: Principal Investigator
  3. R01AI033963 (MADOFF, LAWRENCE C.) Dec 1, 1996 - Nov 30, 2001
    Role: Principal Investigator
  4. R21AI038424 (MADOFF, LAWRENCE C.) Sep 1, 1996 - Feb 28, 1998
    Role: Principal Investigator
  5. K11AI000981 (MADOFF, LAWRENCE C.) Jul 1, 1990 - Jun 30, 1995
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Pollock NR, Berlin D, Smole SC, Madoff LC, Brown C, Henderson K, Larsen E, Hay J, Gabriel S, Gawande AA, Lennon NJ. Implementation of SARS-CoV2 Screening in K-12 Schools Using In-School Pooled Molecular Testing and Deconvolution by Rapid Antigen Test. J Clin Microbiol. 2021 08 18; 59(9):e0112321. PMID: 34191585.
    Citations: 1     Fields:    Translation:Humans
  2. Brown CM, Vostok J, Johnson H, Burns M, Gharpure R, Sami S, Sabo RT, Hall N, Foreman A, Schubert PL, Gallagher GR, Fink T, Madoff LC, Gabriel SB, MacInnis B, Park DJ, Siddle KJ, Harik V, Arvidson D, Brock-Fisher T, Dunn M, Kearns A, Laney AS. Outbreak of SARS-CoV-2 Infections, Including COVID-19 Vaccine Breakthrough Infections, Associated with Large Public Gatherings - Barnstable County, Massachusetts, July 2021. MMWR Morb Mortal Wkly Rep. 2021 Aug 06; 70(31):1059-1062. PMID: 34351882.
    Citations: 27     Fields:    Translation:HumansPHPublic Health
  3. Pollock NR, Tran K, Jacobs JR, Cranston AE, Smith S, O'Kane CY, Roady TJ, Moran A, Scarry A, Carroll M, Volinsky L, Perez G, Patel P, Gabriel S, Lennon NJ, Madoff LC, Brown C, Smole SC. Performance and Operational Evaluation of the Access Bio CareStart Rapid Antigen Test in a High-Throughput Drive-Through Community Testing Site in Massachusetts. Open Forum Infect Dis. 2021 Jul; 8(7):ofab243. PMID: 34250188.
    Citations: 1     
  4. Pollock NR, Jacobs JR, Tran K, Cranston AE, Smith S, O'Kane CY, Roady TJ, Moran A, Scarry A, Carroll M, Volinsky L, Perez G, Patel P, Gabriel S, Lennon NJ, Madoff LC, Brown C, Smole SC. Performance and Implementation Evaluation of the Abbott BinaxNOW Rapid Antigen Test in a High-Throughput Drive-Through Community Testing Site in Massachusetts. J Clin Microbiol. 2021 04 20; 59(5). PMID: 33622768.
    Citations: 17     Fields:    Translation:HumansPHPublic Health
  5. Machalaba C, Raufman J, Anyamba A, Berrian AM, Berthe FCJ, Gray GC, Jonas O, Karesh WB, Larsen MH, Laxminarayan R, Madoff LC, Martin K, Mazet JAK, Mumford E, Parker T, Pintea L, Rostal MK, de Castañeda RR, Vora NM, Wannous C, Weiss LM. Applying a One Health Approach in Global Health and Medicine: Enhancing Involvement of Medical Schools and Global Health Centers. Ann Glob Health. 2021 03 26; 87(1):30. PMID: 33816135.
    Citations: 1     Fields:    
  6. Klompas M, Baker MA, Griesbach D, Tucker R, Gallagher GR, Lang AS, Fink T, Cumming M, Smole S, Madoff LC, Rhee C. Transmission of SARS-CoV-2 from asymptomatic and presymptomatic individuals in healthcare settings despite medical masks and eye protection. Clin Infect Dis. 2021 Mar 11. PMID: 33704451.
    Citations: 8     Fields:    
  7. Lemieux JE, Siddle KJ, Shaw BM, Loreth C, Schaffner SF, Gladden-Young A, Adams G, Fink T, Tomkins-Tinch CH, Krasilnikova LA, DeRuff KC, Rudy M, Bauer MR, Lagerborg KA, Normandin E, Chapman SB, Reilly SK, Anahtar MN, Lin AE, Carter A, Myhrvold C, Kemball ME, Chaluvadi S, Cusick C, Flowers K, Neumann A, Cerrato F, Farhat M, Slater D, Harris JB, Branda JA, Hooper D, Gaeta JM, Baggett TP, O'Connell J, Gnirke A, Lieberman TD, Philippakis A, Burns M, Brown CM, Luban J, Ryan ET, Turbett SE, LaRocque RC, Hanage WP, Gallagher GR, Madoff LC, Smole S, Pierce VM, Rosenberg E, Sabeti PC, Park DJ, MacInnis BL. Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events. Science. 2021 02 05; 371(6529). PMID: 33303686.
    Citations: 35     Fields:    Translation:HumansPHPublic Health
  8. Lemieux JE, Siddle KJ, Shaw BM, Loreth C, Schaffner SF, Gladden-Young A, Adams G, Fink T, Tomkins-Tinch CH, Krasilnikova LA, DeRuff KC, Rudy M, Bauer MR, Lagerborg KA, Normandin E, Chapman SB, Reilly SK, Anahtar MN, Lin AE, Carter A, Myhrvold C, Kemball ME, Chaluvadi S, Cusick C, Flowers K, Neumann A, Cerrato F, Farhat M, Slater D, Harris JB, Branda J, Hooper D, Gaeta JM, Baggett TP, O'Connell J, Gnirke A, Lieberman TD, Philippakis A, Burns M, Brown CM, Luban J, Ryan ET, Turbett SE, LaRocque RC, Hanage WP, Gallagher GR, Madoff LC, Smole S, Pierce VM, Rosenberg E, Sabeti PC, Park DJ, Maclnnis BL. Phylogenetic analysis of SARS-CoV-2 in the Boston area highlights the role of recurrent importation and superspreading events. medRxiv. 2020 Aug 25. PMID: 32869040.
    Citations: 2     
  9. Desai AN, Ramatowski JW, Marano N, Madoff LC, Lassmann B. Infectious disease outbreaks among forcibly displaced persons: an analysis of ProMED reports 1996-2016. Confl Health. 2020; 14:49. PMID: 32704307.
    Citations: 2     
  10. Theodoropoulos NM, Bolstorff B, Bozorgzadeh A, Brandeburg C, Cumming M, Daly JS, Ellison RT, Forsberg K, Gade L, Gibson L, Greenough T, Litvintseva AP, Mack DA, Madoff L, Martins PN, McHale E, Melvin Z, Movahedi B, Stiles T, Vallabhaneni S, Levitz SM. Candida auris outbreak involving liver transplant recipients in a surgical intensive care unit. Am J Transplant. 2020 12; 20(12):3673-3679. PMID: 32530145.
    Citations: 3     Fields:    Translation:HumansAnimalsPHPublic Health
  11. Vaughn EL, Vo QT, Vostok J, Stiles T, Lang A, Brown CM, Klevens RM, Madoff L. Linking Epidemiology and Whole-Genome Sequencing to Investigate Salmonella Outbreak, Massachusetts, USA, 2018. Emerg Infect Dis. 2020 07; 26(7):1538-1541. PMID: 32568039.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  12. Pollack M, Madoff LC, Tambyah PA, Mendelson M, Holmes A. International Society for Infectious Diseases - Sustained and continuous funding for WHO. Int J Infect Dis. 2020 07; 96:458. PMID: 32425640.
    Citations:    Fields:    
  13. Desai AN, Seshasayee SM, Majumder MS, Lassmann B, Madoff LC, Cohn EL, Brownstein JS. Tuberculosis and foreign-born populations in the United States: A mixed methods pilot study of media reporting and political identification. PLoS One. 2020; 15(4):e0230967. PMID: 32315312.
    Citations:    Fields:    Translation:Humans
  14. Petersen E, Hui D, Hamer DH, Blumberg L, Madoff LC, Pollack M, Lee SS, McLellan S, Memish Z, Praharaj I, Wasserman S, Ntoumi F, Azhar EI, Mchugh TD, Kock R, Ippolito G, Zumla A, Koopmans M. Li Wenliang, a face to the frontline healthcare worker. The first doctor to notify the emergence of the SARS-CoV-2, (COVID-19), outbreak. Int J Infect Dis. 2020 04; 93:205-207. PMID: 32142979.
    Citations: 16     Fields:    Translation:HumansCellsPHPublic Health
  15. Wohl S, Metsky HC, Schaffner SF, Piantadosi A, Burns M, Lewnard JA, Chak B, Krasilnikova LA, Siddle KJ, Matranga CB, Bankamp B, Hennigan S, Sabina B, Byrne EH, McNall RJ, Shah RR, Qu J, Park DJ, Gharib S, Fitzgerald S, Barreira P, Fleming S, Lett S, Rota PA, Madoff LC, Yozwiak NL, MacInnis BL, Smole S, Grad YH, Sabeti PC. Combining genomics and epidemiology to track mumps virus transmission in the United States. PLoS Biol. 2020 02; 18(2):e3000611. PMID: 32045407.
    Citations: 7     Fields:    Translation:HumansCellsPHPublic Health
  16. Desai AN, Kraemer MUG, Bhatia S, Cori A, Nouvellet P, Herringer M, Cohn EL, Carrion M, Brownstein JS, Madoff LC, Lassmann B. Real-time Epidemic Forecasting: Challenges and Opportunities. Health Secur. 2019 Jul/Aug; 17(4):268-275. PMID: 31433279.
    Citations: 16     Fields:    Translation:HumansPHPublic Health
  17. Desai AN, Anyoha A, Madoff LC, Lassmann B. Changing epidemiology of Listeria monocytogenes outbreaks, sporadic cases, and recalls globally: A review of ProMED reports from 1996 to 2018. Int J Infect Dis. 2019 Jul; 84:48-53. PMID: 31051276.
    Citations: 21     Fields:    Translation:HumansCellsPHPublic Health
  18. Shenoy ES, Pierce VM, Walters MS, Moulton-Meissner H, Lawsin A, Lonsway D, Shugart A, McAllister G, Halpin AL, Zambrano-Gonzalez A, Ryan EE, Suslak D, DeJesus A, Barton K, Madoff LC, McHale E, DeMaria A, Hooper DC. Transmission of Mobile Colistin Resistance (mcr-1) by Duodenoscope. Clin Infect Dis. 2019 04 08; 68(8):1327-1334. PMID: 30204838.
    Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
  19. Desai AN, Madoff LC. Bending the epidemic curve: advancements and opportunities to reduce the threat of emerging pathogens. Epidemiol Infect. 2019 01; 147:e168. PMID: 30955504.
    Citations:    Fields:    Translation:HumansPHPublic Health
  20. Lorthe TS, Pollack MP, Lassmann B, Brownstein JS, Cohn E, Divi N, Herrera-Guibert DJ, Olsen J, Smolinski MS, Madoff LC. Evaluation of the EpiCore outbreak verification system. Bull World Health Organ. 2018 May 01; 96(5):327-334. PMID: 29875517.
    Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
  21. Ramatowski JW, Lee CX, Mantzavino A, Ribas J, Guerra W, Preston ND, Schernhammer E, Madoff LC, Lassmann B. Planning an innovation marathon at an infectious disease conference with results from the International Meeting on Emerging Diseases and Surveillance 2016 Hackathon. Int J Infect Dis. 2017 Dec; 65:93-97. PMID: 29017856.
    Citations:    Fields:    Translation:HumansPHPublic Health
  22. Huff AG, Allen T, Whiting K, Williams F, Hunter L, Gold Z, Madoff LC, Karesh WB. Biosurveillance: a systematic review of global infectious disease surveillance systems from 1900 to 2016. Rev Sci Tech. 2017 Aug; 36(2):513-524. PMID: 30152467.
    Citations: 2     Fields:    Translation:HumansAnimalsPHPublic Health
  23. Carrion M, Madoff LC. ProMED-mail: 22 years of digital surveillance of emerging infectious diseases. Int Health. 2017 05 01; 9(3):177-183. PMID: 28582558.
    Citations: 15     Fields:    Translation:HumansAnimalsPHPublic Health
  24. Lassmann B, Madoff LC. Highlights from the 6th International Meeting on Emerging Diseases and Surveillance (IMED 2016) Vienna, Austria from Nov 3 to 7, 2016. Int J Infect Dis. 2016 12; 53S:1-3. PMID: 27955993.
    Citations:    Fields:    
  25. Powell GA, Zinszer K, Verma A, Bahk C, Madoff L, Brownstein J, Buckeridge D. Media content about vaccines in the United States and Canada, 2012-2014: An analysis using data from the Vaccine Sentimeter. Vaccine. 2016 12 07; 34(50):6229-6235. PMID: 27817958.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  26. Kluberg SA, Mekaru SR, McIver DJ, Madoff LC, Crawley AW, Smolinski MS, Brownstein JS. Global Capacity for Emerging Infectious Disease Detection, 1996-2014. Emerg Infect Dis. 2016 10; 22(10):E1-6. PMID: 27649306.
    Citations: 11     Fields:    Translation:HumansPHPublic Health
  27. Chancellor JR, Padmanabhan SP, Greenough TC, Sacra R, Ellison RT, Madoff LC, Droms RJ, Hinkle DM, Asdourian GK, Finberg RW, Stroher U, Uyeki TM, Cerón OM. Uveitis and Systemic Inflammatory Markers in Convalescent Phase of Ebola Virus Disease. Emerg Infect Dis. 2016 Feb; 22(2):295-7. PMID: 26812218.
    Citations: 14     Fields:    Translation:HumansCells
  28. Bahk CY, Cumming M, Paushter L, Madoff LC, Thomson A, Brownstein JS. Publicly Available Online Tool Facilitates Real-Time Monitoring Of Vaccine Conversations And Sentiments. Health Aff (Millwood). 2016 Feb; 35(2):341-7. PMID: 26858390.
    Citations: 20     Fields:    Translation:HumansPHPublic Health
  29. Iroh Tam PY, Madoff LC, O'Connell M, Pelton SI. Seasonal variation in penicillin susceptibility and invasive pneumococcal disease. Pediatr Infect Dis J. 2015 Apr; 34(4):456-7. PMID: 25379834.
    Citations: 2     Fields:    Translation:HumansCells
  30. Vayena E, Salathé M, Madoff LC, Brownstein JS. Ethical challenges of big data in public health. PLoS Comput Biol. 2015 Feb; 11(2):e1003904. PMID: 25664461.
    Citations: 64     Fields:    Translation:HumansPHPublic Health
  31. Iroh Tam PY, Coombes B, Madoff L, Pelton SI. Severity of invasive pneumococcal disease in children caused by susceptible and nonsusceptible isolates. Pediatr Infect Dis J. 2014 Nov; 33(11):1206-7. PMID: 25361416.
    Citations: 1     Fields:    Translation:HumansCells
  32. Petersen E, Pollack MM, Madoff LC. Health-care associate transmission of Middle East Respiratory Syndrome Corona virus, MERS-CoV, in the Kingdom of Saudi Arabia. Int J Infect Dis. 2014 Dec; 29:299-300. PMID: 25461234.
    Citations: 6     Fields:    Translation:HumansCells
  33. Pigott DM, Golding N, Messina JP, Battle KE, Duda KA, Balard Y, Bastien P, Pratlong F, Brownstein JS, Freifeld CC, Mekaru SR, Madoff LC, George DB, Myers MF, Hay SI. Global database of leishmaniasis occurrence locations, 1960-2012. Sci Data. 2014; 1:140036. PMID: 25984344.
    Citations: 21     Fields:    Translation:HumansPHPublic Health
  34. Placzek HE, Madoff LC. Association of age and comorbidity on 2009 influenza A pandemic H1N1-related intensive care unit stay in Massachusetts. Am J Public Health. 2014 Nov; 104(11):e118-25. PMID: 25211746.
    Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
  35. Iroh Tam PY, Madoff LC, Coombes B, Pelton SI. Invasive pneumococcal disease after implementation of 13-valent conjugate vaccine. Pediatrics. 2014 Aug; 134(2):210-7. PMID: 25002663.
    Citations: 8     Fields:    Translation:HumansCells
  36. Barboza P, Vaillant L, Le Strat Y, Hartley DM, Nelson NP, Mawudeku A, Madoff LC, Linge JP, Collier N, Brownstein JS, Astagneau P. Factors influencing performance of internet-based biosurveillance systems used in epidemic intelligence for early detection of infectious diseases outbreaks. PLoS One. 2014; 9(3):e90536. PMID: 24599062.
    Citations: 20     Fields:    Translation:HumansPHPublic Health
  37. Madoff LC, Li A. Web-Based Surveillance Systems for Human, Animal, and Plant Diseases. Microbiol Spectr. 2014 Feb; 2(1):OH-0015-2012. PMID: 26082109.
    Citations: 4     Fields:    Translation:HumansAnimals
  38. Yih WK, Cocoros NM, Crockett M, Klompas M, Kruskal BA, Kulldorff M, Lazarus R, Madoff LC, Morrison MJ, Smole S, Platt R. Automated influenza-like illness reporting--an efficient adjunct to traditional sentinel surveillance. Public Health Rep. 2014 Jan-Feb; 129(1):55-63. PMID: 24381360.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  39. Placzek H, Madoff L. Effect of race/ethnicity and socioeconomic status on pandemic H1N1-related outcomes in Massachusetts. Am J Public Health. 2014 Jan; 104(1):e31-8. PMID: 24228651.
    Citations: 12     Fields:    Translation:HumansCellsPHPublic Health
  40. Hartley DM, Nelson NP, Arthur RR, Barboza P, Collier N, Lightfoot N, Linge JP, van der Goot E, Mawudeku A, Madoff LC, Vaillant L, Walters R, Yangarber R, Mantero J, Corley CD, Brownstein JS. An overview of internet biosurveillance. Clin Microbiol Infect. 2013 Nov; 19(11):1006-13. PMID: 23789639.
    Citations: 31     Fields:    Translation:HumansPHPublic Health
  41. Klinzing DC, Ishmael N, Hotopp JCD, Tettelin H, Shields KR, Madoff LC, Puopolo KM. The two-component response regulator LiaR regulates cell wall stress responses, pili expression and virulence in group B Streptococcus. Microbiology (Reading). 2013 Jul; 159(Pt 7):1521-1534. PMID: 23704792.
    Citations: 26     Translation:HumansAnimalsCells
  42. Larson HJ, Smith DM, Paterson P, Cumming M, Eckersberger E, Freifeld CC, Ghinai I, Jarrett C, Paushter L, Brownstein JS, Madoff LC. Measuring vaccine confidence: analysis of data obtained by a media surveillance system used to analyse public concerns about vaccines. Lancet Infect Dis. 2013 Jul; 13(7):606-13. PMID: 23676442.
    Citations: 57     Fields:    Translation:HumansPHPublic Health
  43. Barboza P, Vaillant L, Mawudeku A, Nelson NP, Hartley DM, Madoff LC, Linge JP, Collier N, Brownstein JS, Yangarber R, Astagneau P. Evaluation of epidemic intelligence systems integrated in the early alerting and reporting project for the detection of A/H5N1 influenza events. PLoS One. 2013; 8(3):e57252. PMID: 23472077.
    Citations: 26     Fields:    Translation:HumansCellsPHPublic Health
  44. Pollack MP, Pringle C, Madoff LC, Memish ZA. Latest outbreak news from ProMED-mail: novel coronavirus -- Middle East. Int J Infect Dis. 2013 Feb; 17(2):e143-4. PMID: 23270612.
    Citations: 17     Fields:    Translation:HumansCellsPHPublic Health
  45. Chan EH, Scales DA, Brewer TF, Madoff LC, Pollack MP, Hoen AG, Choden T, Brownstein JS. Forecasting high-priority infectious disease surveillance regions: a socioeconomic model. Clin Infect Dis. 2013 Feb; 56(4):517-24. PMID: 23118271.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  46. Mondor L, Brownstein JS, Chan E, Madoff LC, Pollack MP, Buckeridge DL, Brewer TF. Timeliness of nongovernmental versus governmental global outbreak communications. Emerg Infect Dis. 2012 Jul; 18(7):1184-7. PMID: 22709741.
    Citations: 13     Fields:    Translation:HumansPHPublic Health
  47. Fisher MC, Henk DA, Briggs CJ, Brownstein JS, Madoff LC, McCraw SL, Gurr SJ. Emerging fungal threats to animal, plant and ecosystem health. Nature. 2012 Apr 11; 484(7393):186-94. PMID: 22498624.
    Citations: 615     Fields:    Translation:HumansAnimals
  48. Newton AE, Heiman KE, Schmitz A, Török T, Apostolou A, Hanson H, Gounder P, Bohm S, Kurkjian K, Parsons M, Talkington D, Stroika S, Madoff LC, Elson F, Sweat D, Cantu V, Akwari O, Mahon BE, Mintz ED. Cholera in United States associated with epidemic in Hispaniola. Emerg Infect Dis. 2011 Nov; 17(11):2166-8. PMID: 22204035.
    Citations: 12     Fields:    Translation:HumansCellsPHPublic Health
  49. Ryan ET, Madoff LC, Ferraro MJ. Case records of the Massachusetts General Hospital. Case 20-2011. A 30-year-old man with diarrhea after a trip to the Dominican Republic. N Engl J Med. 2011 Jun 30; 364(26):2536-41. PMID: 21714651.
    Citations: 3     Fields:    Translation:HumansCells
  50. Madoff LC, Fisman DN, Kass-Hout T. A new approach to monitoring dengue activity. PLoS Negl Trop Dis. 2011 May; 5(5):e1215. PMID: 21647309.
    Citations: 15     Fields:    Translation:HumansPHPublic Health
  51. Chan EH, Brewer TF, Madoff LC, Pollack MP, Sonricker AL, Keller M, Freifeld CC, Blench M, Mawudeku A, Brownstein JS. Global capacity for emerging infectious disease detection. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21701-6. PMID: 21115835.
    Citations: 73     Fields:    Translation:HumansPHPublic Health
  52. Placzek H, Madoff LC. The use of immunization registry-based data in vaccine effectiveness studies. Vaccine. 2011 Jan 10; 29(3):399-411. PMID: 21087687.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  53. Hartley D, Nelson N, Walters R, Arthur R, Yangarber R, Madoff L, Linge J, Mawudeku A, Collier N, Brownstein J, Thinus G, Lightfoot N. Landscape of international event-based biosurveillance. Emerg Health Threats J. 2010; 3:e3. PMID: 22460393.
    Citations: 36     Fields:    
  54. Brownstein JS, Freifeld CC, Madoff LC. Influenza A (H1N1) virus, 2009--online monitoring. N Engl J Med. 2009 May 21; 360(21):2156. PMID: 19423868.
    Citations: 22     Fields:    Translation:HumansCellsPHPublic Health
  55. Brownstein JS, Freifeld CC, Madoff LC. Digital disease detection--harnessing the Web for public health surveillance. N Engl J Med. 2009 May 21; 360(21):2153-5, 2157. PMID: 19423867.
    Citations: 211     Fields:    Translation:HumansPHPublic Health
  56. Klinzing DC, Madoff LC, Puopolo KM. Genomic analysis identifies a transcription-factor binding motif regulating expression of the alpha C protein in Group B Streptococcus. Microb Pathog. 2009 Jun; 46(6):315-20. PMID: 19328843.
    Citations: 2     Fields:    Translation:HumansCells
  57. Baron MJ, Wong SL, Nybakken K, Carey VJ, Madoff LC. Host glycosaminoglycan confers susceptibility to bacterial infection in Drosophila melanogaster. Infect Immun. 2009 Feb; 77(2):860-6. PMID: 19047407.
    Citations: 6     Fields:    Translation:AnimalsCells
  58. Kling DE, Cavicchio AJ, Sollinger CA, Madoff LC, Schnitzer JJ, Kinane TB. Lactic acid is a potential virulence factor for group B Streptococcus. Microb Pathog. 2009 Jan; 46(1):43-52. PMID: 19010409.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  59. Yang HH, Mascuch SJ, Madoff LC, Paoletti LC. Recombinant group B Streptococcus alpha-like protein 3 is an effective immunogen and carrier protein. Clin Vaccine Immunol. 2008 Jul; 15(7):1035-41. PMID: 18463225.
    Citations: 7     Fields:    Translation:AnimalsCells
  60. Pannaraj PS, Kelly JK, Rench MA, Madoff LC, Edwards MS, Baker CJ. Alpha C protein-specific immunity in humans with group B streptococcal colonization and invasive disease. Vaccine. 2008 Jan 24; 26(4):502-8. PMID: 18155812.
    Citations: 5     Fields:    Translation:HumansCells
  61. Bolduc GR, Madoff LC. The group B streptococcal alpha C protein binds alpha1beta1-integrin through a novel KTD motif that promotes internalization of GBS within human epithelial cells. Microbiology (Reading). 2007 Dec; 153(Pt 12):4039-4049. PMID: 18048918.
    Citations: 12     Translation:HumansCells
  62. Yang HH, Madoff LC, Guttormsen HK, Liu YD, Paoletti LC. Recombinant group B streptococcus Beta C protein and a variant with the deletion of its immunoglobulin A-binding site are protective mouse maternal vaccines and effective carriers in conjugate vaccines. Infect Immun. 2007 Jul; 75(7):3455-61. PMID: 17470542.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  63. Puopolo KM, Madoff LC. Type IV neonatal early-onset group B streptococcal disease in a United States hospital. J Clin Microbiol. 2007 Apr; 45(4):1360-2. PMID: 17267636.
    Citations: 7     Fields:    Translation:HumansCells
  64. Baron MJ, Filman DJ, Prophete GA, Hogle JM, Madoff LC. Identification of a glycosaminoglycan binding region of the alpha C protein that mediates entry of group B Streptococci into host cells. J Biol Chem. 2007 Apr 06; 282(14):10526-36. PMID: 17259175.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  65. Pannaraj PS, Kelly JK, Madoff LC, Rench MA, Lachenauer CS, Edwards MS, Baker CJ. Group B Streptococcus bacteremia elicits beta C protein-specific IgMand IgG in humans. J Infect Dis. 2007 Feb 01; 195(3):353-6. PMID: 17205473.
    Citations: 5     Fields:    Translation:HumansCells
  66. Madoff L. Cooperation between animal and human health sectors is key to the detection, surveillance, and control of emerging disease: IMED 2007 meeting in Vienna, February 2007. Euro Surveill. 2006 Dec 21; 11(12):E061221.4. PMID: 17213572.
    Citations: 2     Fields:    Translation:HumansAnimalsPHPublic Health
  67. Cowen P, Garland T, Hugh-Jones ME, Shimshony A, Handysides S, Kaye D, Madoff LC, Pollack MP, Woodall J. Evaluation of ProMED-mail as an electronic early warning system for emerging animal diseases: 1996 to 2004. J Am Vet Med Assoc. 2006 Oct 01; 229(7):1090-9. PMID: 17014355.
    Citations: 17     Fields:    Translation:HumansAnimalsPHPublic Health
  68. Ramaswamy SV, Ferrieri P, Madoff LC, Flores AE, Kumar N, Tettelin H, Paoletti LC. Identification of novel cps locus polymorphisms in nontypable group B Streptococcus. J Med Microbiol. 2006 Jun; 55(Pt 6):775-783. PMID: 16687599.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  69. Madoff LC, Woodall JP. The internet and the global monitoring of emerging diseases: lessons from the first 10 years of ProMED-mail. Arch Med Res. 2005 Nov-Dec; 36(6):724-30. PMID: 16216654.
    Citations: 35     Fields:    Translation:HumansAnimalsPHPublic Health
  70. Tettelin H, Masignani V, Cieslewicz MJ, Donati C, Medini D, Ward NL, Angiuoli SV, Crabtree J, Jones AL, Durkin AS, Deboy RT, Davidsen TM, Mora M, Scarselli M, Margarit y Ros I, Peterson JD, Hauser CR, Sundaram JP, Nelson WC, Madupu R, Brinkac LM, Dodson RJ, Rosovitz MJ, Sullivan SA, Daugherty SC, Haft DH, Selengut J, Gwinn ML, Zhou L, Zafar N, Khouri H, Radune D, Dimitrov G, Watkins K, O'Connor KJ, Smith S, Utterback TR, White O, Rubens CE, Grandi G, Madoff LC, Kasper DL, Telford JL, Wessels MR, Rappuoli R, Fraser CM. Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: implications for the microbial "pan-genome". Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13950-5. PMID: 16172379.
    Citations: 793     Fields:    Translation:Cells
  71. Madoff LC. Immunity to group a streptococcal M proteins: forging a single-edged sword. Clin Infect Dis. 2005 Oct 15; 41(8):1123-4. PMID: 16163630.
    Citations:    Fields:    Translation:HumansCells
  72. Maione D, Margarit I, Rinaudo CD, Masignani V, Mora M, Scarselli M, Tettelin H, Brettoni C, Iacobini ET, Rosini R, D'Agostino N, Miorin L, Buccato S, Mariani M, Galli G, Nogarotto R, Nardi-Dei V, Nardi Dei V, Vegni F, Fraser C, Mancuso G, Teti G, Madoff LC, Paoletti LC, Rappuoli R, Kasper DL, Telford JL, Grandi G. Identification of a universal Group B streptococcus vaccine by multiple genome screen. Science. 2005 Jul 01; 309(5731):148-50. PMID: 15994562.
    Citations: 163     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  73. Puopolo KM, Madoff LC, Eichenwald EC. Early-onset group B streptococcal disease in the era of maternal screening. Pediatrics. 2005 May; 115(5):1240-6. PMID: 15867030.
    Citations: 55     Fields:    Translation:HumansCells
  74. Aupérin TC, Bolduc GR, Baron MJ, Heroux A, Filman DJ, Madoff LC, Hogle JM. Crystal structure of the N-terminal domain of the group B streptococcus alpha C protein. J Biol Chem. 2005 May 06; 280(18):18245-52. PMID: 15753100.
    Citations: 10     Fields:    Translation:HumansCells
  75. Mikamo H, Johri AK, Paoletti LC, Madoff LC, Onderdonk AB. Adherence to, invasion by, and cytokine production in response to serotype VIII group B Streptococci. Infect Immun. 2004 Aug; 72(8):4716-22. PMID: 15271933.
    Citations: 11     Fields:    Translation:HumansCells
  76. Madoff LC. ProMED-mail: an early warning system for emerging diseases. Clin Infect Dis. 2004 Jul 15; 39(2):227-32. PMID: 15307032.
    Citations: 68     Fields:    Translation:HumansAnimalsPHPublic Health
  77. Baron MJ, Bolduc GR, Goldberg MB, Aupérin TC, Madoff LC. Alpha C protein of group B Streptococcus binds host cell surface glycosaminoglycan and enters cells by an actin-dependent mechanism. J Biol Chem. 2004 Jun 04; 279(23):24714-23. PMID: 15044471.
    Citations: 34     Fields:    Translation:HumansCells
  78. Puopolo KM, Madoff LC. Upstream short sequence repeats regulate expression of the alpha C protein of group B Streptococcus. Mol Microbiol. 2003 Nov; 50(3):977-91. PMID: 14617155.
    Citations: 11     Fields:    Translation:AnimalsCells
  79. Bolduc GR, Baron MJ, Gravekamp C, Lachenauer CS, Madoff LC. The alpha C protein mediates internalization of group B Streptococcus within human cervical epithelial cells. Cell Microbiol. 2002 Nov; 4(11):751-8. PMID: 12427097.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  80. Tettelin H, Masignani V, Cieslewicz MJ, Eisen JA, Peterson S, Wessels MR, Paulsen IT, Nelson KE, Margarit I, Read TD, Madoff LC, Wolf AM, Beanan MJ, Brinkac LM, Daugherty SC, DeBoy RT, Durkin AS, Kolonay JF, Madupu R, Lewis MR, Radune D, Fedorova NB, Scanlan D, Khouri H, Mulligan S, Carty HA, Cline RT, Van Aken SE, Gill J, Scarselli M, Mora M, Iacobini ET, Brettoni C, Galli G, Mariani M, Vegni F, Maione D, Rinaudo D, Rappuoli R, Telford JL, Kasper DL, Grandi G, Fraser CM. Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12391-6. PMID: 12200547.
    Citations: 197     Fields:    Translation:HumansCells
  81. Paoletti LC, Madoff LC. Vaccines to prevent neonatal GBS infection. Semin Neonatol. 2002 Aug; 7(4):315-23. PMID: 12401301.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  82. Lachenauer CS, Baker CJ, Baron MJ, Kasper DL, Gravekamp C, Madoff LC. Quantitative determination of immunoglobulin G specific for group B streptococcal beta C protein in human maternal serum. J Infect Dis. 2002 Feb 01; 185(3):368-74. PMID: 11807719.
    Citations: 9     Fields:    Translation:HumansCells
  83. Puopolo KM, Hollingshead SK, Carey VJ, Madoff LC. Tandem repeat deletion in the alpha C protein of group B streptococcus is recA independent. Infect Immun. 2001 Aug; 69(8):5037-45. PMID: 11447184.
    Citations: 8     Fields:    Translation:AnimalsCells
  84. Johannsen EC, Sifri CD, Madoff LC. Pyogenic liver abscesses. Infect Dis Clin North Am. 2000 Sep; 14(3):547-63, vii. PMID: 10987109.
    Citations: 46     Fields:    Translation:Humans
  85. Lachenauer CS, Creti R, Michel JL, Madoff LC. Mosaicism in the alpha-like protein genes of group B streptococci. Proc Natl Acad Sci U S A. 2000 Aug 15; 97(17):9630-5. PMID: 10944228.
    Citations: 48     Fields:    Translation:Cells
  86. Davies JK, Paoletti LC, McDuffie RS, Madoff LC, Lee S, Eskens J, Gibbs RS. A randomized trial of conjugated group B streptococcal type Ia vaccine in a rabbit model of ascending infection. Am J Obstet Gynecol. 1999 Oct; 181(4):803-8. PMID: 10521733.
    Citations: 5     Fields:    Translation:AnimalsCells
  87. Ross RA, Madoff LC, Paoletti LC. Regulation of cell component production by growth rate in the group B Streptococcus. J Bacteriol. 1999 Sep; 181(17):5389-94. PMID: 10464211.
    Citations: 6     Fields:    Translation:Cells
  88. Kling DE, Madoff LC, Michel JL. Subcellular fractionation of group B Streptococcus. Biotechniques. 1999 Jul; 27(1):24-6, 28. PMID: 10407656.
    Citations: 10     Fields:    Translation:Cells
  89. Gravekamp C, Kasper DL, Paoletti LC, Madoff LC. Alpha C protein as a carrier for type III capsular polysaccharide and as a protective protein in group B streptococcal vaccines. Infect Immun. 1999 May; 67(5):2491-6. PMID: 10225912.
    Citations: 16     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  90. Lachenauer CS, Kasper DL, Shimada J, Ichiman Y, Ohtsuka H, Kaku M, Paoletti LC, Ferrieri P, Madoff LC. Serotypes VI and VIII predominate among group B streptococci isolated from pregnant Japanese women. J Infect Dis. 1999 Apr; 179(4):1030-3. PMID: 10068604.
    Citations: 59     Fields:    Translation:HumansCells
  91. Huebner J, Wang Y, Krueger WA, Madoff LC, Martirosian G, Boisot S, Goldmann DA, Kasper DL, Tzianabos AO, Pier GB. Isolation and chemical characterization of a capsular polysaccharide antigen shared by clinical isolates of Enterococcus faecalis and vancomycin-resistant Enterococcus faecium. Infect Immun. 1999 Mar; 67(3):1213-9. PMID: 10024563.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  92. Gravekamp C, Rosner B, Madoff LC. Deletion of repeats in the alpha C protein enhances the pathogenicity of group B streptococci in immune mice. Infect Immun. 1998 Sep; 66(9):4347-54. PMID: 9712787.
    Citations: 24     Fields:    Translation:AnimalsCellsPHPublic Health
  93. Gravekamp C, Kasper DL, Michel JL, Kling DE, Carey V, Madoff LC. Immunogenicity and protective efficacy of the alpha C protein of group B streptococci are inversely related to the number of repeats. Infect Immun. 1997 Dec; 65(12):5216-21. PMID: 9393818.
    Citations: 22     Fields:    Translation:AnimalsCells
  94. Castellani RJ, Parchi P, Madoff L, Gambetti P, McKeever P. Biopsy diagnosis of Creutzfeldt-Jakob disease by western blot: a case report. Hum Pathol. 1997 May; 28(5):623-6. PMID: 9158712.
    Citations: 2     Fields:    Translation:Humans
  95. Kling DE, Gravekamp C, Madoff LC, Michel JL. Characterization of two distinct opsonic and protective epitopes within the alpha C protein of the group B Streptococcus. Infect Immun. 1997 Apr; 65(4):1462-7. PMID: 9119488.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  96. Gravekamp C, Kasper DL, Madoff LC. Immunization with a single-repeat alpha C protein may prevent escape of lower repeat mutants of group B Streptococcus. Adv Exp Med Biol. 1997; 418:855-7. PMID: 9331787.
    Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
  97. Lachenauer CS, Madoff LC. Cloning and expression in Escherichia coli of a protective surface protein from type V group B streptococci. Adv Exp Med Biol. 1997; 418:615-8. PMID: 9331727.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  98. Lachenauer CS, Madoff LC. A protective surface protein from type V group B streptococci shares N-terminal sequence homology with the alpha C protein. Infect Immun. 1996 Oct; 64(10):4255-60. PMID: 8926097.
    Citations: 21     Fields:    Translation:AnimalsCells
  99. Gravekamp C, Horensky DS, Michel JL, Madoff LC. Variation in repeat number within the alpha C protein of group B streptococci alters antigenicity and protective epitopes. Infect Immun. 1996 Sep; 64(9):3576-83. PMID: 8751902.
    Citations: 25     Fields:    Translation:AnimalsCells
  100. Madoff LC, Michel JL, Gong EW, Kling DE, Kasper DL. Group B streptococci escape host immunity by deletion of tandem repeat elements of the alpha C protein. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4131-6. PMID: 8633028.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  101. Madoff LC, Paoletti LC, Tai JY, Kasper DL. Maternal immunization of mice with group B streptococcal type III polysaccharide-beta C protein conjugate elicits protective antibody to multiple serotypes. J Clin Invest. 1994 Jul; 94(1):286-92. PMID: 7518832.
    Citations: 27     Fields:    Translation:AnimalsCellsPHPublic Health
  102. Hervás JA, González L, Gil J, Paoletti LC, Madoff LC, Benedí VJ. Neonatal group B streptococcal infection in Mallorca, Spain. Clin Infect Dis. 1993 May; 16(5):714-8. PMID: 8099503.
    Citations: 8     Fields:    Translation:HumansCells
  103. Madoff LC, Michel JL, Gong EW, Rodewald AK, Kasper DL. Protection of neonatal mice from group B streptococcal infection by maternal immunization with beta C protein. Infect Immun. 1992 Dec; 60(12):4989-94. PMID: 1452329.
    Citations: 31     Fields:    Translation:AnimalsCellsPHPublic Health
  104. Michel JL, Madoff LC, Olson K, Kling DE, Kasper DL, Ausubel FM. Large, identical, tandem repeating units in the C protein alpha antigen gene, bca, of group B streptococci. Proc Natl Acad Sci U S A. 1992 Nov 01; 89(21):10060-4. PMID: 1438195.
    Citations: 65     Fields:    Translation:Cells
  105. Madoff LC, Hori S, Michel JL, Baker CJ, Kasper DL. Phenotypic diversity in the alpha C protein of group B streptococci. Infect Immun. 1991 Aug; 59(8):2638-44. PMID: 1855984.
    Citations: 32     Fields:    Translation:HumansCells
  106. Michel JL, Madoff LC, Kling DE, Kasper DL, Ausubel FM. Cloned alpha and beta C-protein antigens of group B streptococci elicit protective immunity. Infect Immun. 1991 Jun; 59(6):2023-8. PMID: 1674738.
    Citations: 45     Fields:    Translation:AnimalsCells
  107. Madoff LC, Michel JL, Kasper DL. A monoclonal antibody identifies a protective C-protein alpha-antigen epitope in group B streptococci. Infect Immun. 1991 Jan; 59(1):204-10. PMID: 1702759.
    Citations: 47     Fields:    Translation:AnimalsCells
  108. Squires KE, Murphy WF, Madoff LC, Murray HW. Interferon-gamma and Mycobacterium avium-intracellulare infection. J Infect Dis. 1989 Mar; 159(3):599-600. PMID: 2492589.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
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