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Sengwee Darren Toh, D.S.

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Overview
Darren Toh, ScD is an Associate Professor in the Department of Population Medicine at Harvard Medical School and Harvard Pilgrim Health Care Institute. He is a pharmacoepidemiologist with an interest in the comparative safety and effectiveness research of medical products. His research has been focused on 1) assessing the risks and benefits of medical products using electronic data collected as part of routine healthcare delivery, and 2) developing and applying privacy-protecting analytic methods to conduct multi-center studies in distributed data networks.

Darren is Director of Scientific Programs of the Therapeutics Research and Infectious Disease Epidemiology (TIDE) group. He is also Director of Applied Surveillance at the Operations Center of the FDA-funded Sentinel System, a congressionally mandated national medical product safety surveillance system. He is Principal Investigator of projects funded by the National Institutes of Health (U01EB023683), the Patient-Centered Outcomes Research Institute (ME-1403-11305), and the Food and Drug Administration. Darren received his doctoral degree in Epidemiology from the Harvard School of Public Health.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Taylor LG, Panucci G, Mosholder AD, Toh S, Huang TY. Antipsychotic Use and Stroke: A Retrospective Comparative Study in a Non-Elderly Population. J Clin Psychiatry. 2019 Jun 04; 80(4). PMID: 31163104.
    Citations:    
  2. Desai RJ, Wyss R, Abdia Y, Toh S, Johnson M, Lee H, Karami S, Major JM, Nguyen M, Wang SV, Franklin JM, Gagne JJ. Evaluating the use of bootstrapping in cohort studies conducted with 1:1 propensity score matching-A plasmode simulation study. Pharmacoepidemiol Drug Saf. 2019 Jun; 28(6):879-886. PMID: 31020732.
    Citations:    
  3. Her QL, Toh S. Sound-Alike Look-Alike Confusion and Matching Medication Product Attributes: Simulated Case-Control Studies. Ann Pharmacother. 2019 Apr 18; 1060028019838239. PMID: 30999762.
    Citations:    
  4. Lin PD, Daley MF, Boone-Heinonen J, Rifas-Shiman SL, Bailey LC, Forrest CB, Horgan CE, Sturtevant JL, Toh S, Young JG, Block JP. Comparing Prescribing and Dispensing Data of the PCORnet Common Data Model Within PCORnet Antibiotics and Childhood Growth Study. EGEMS (Wash DC). 2019 Apr 12; 7(1):11. PMID: 30993145.
    Citations:    
  5. Li X, Fireman BH, Curtis JR, Arterburn DE, Fisher DP, Moyneur É, Gallagher M, Raebel MA, Nowell WB, Lagreid L, Toh S. Validity of Privacy-Protecting Analytical Methods That Use Only Aggregate-Level Information to Conduct Multivariable-Adjusted Analysis in Distributed Data Networks. Am J Epidemiol. 2019 Apr 01; 188(4):709-723. PMID: 30535131.
    Citations:    Fields:    
  6. Singh S, Fouayzi H, Anzuoni K, Goldman L, Min JY, Griffin M, Grijalva CG, Morrow JA, Whitmore CC, Leonard CE, Selvan M, Nair V, Zhou Y, Toh S, Petrone A, Williams J, Fazio-Eynullayeva E, Swain R, Tyler Coyle D, Andrade S. Diagnostic Algorithms for Cardiovascular Death in Administrative Claims Databases: A Systematic Review. Drug Saf. 2019 Apr; 42(4):515-527. PMID: 30471046.
    Citations:    Fields:    
  7. Petrone AB, DuCott A, Gagne JJ, Toh S, Maro JC. The Devil's in the details: Reports on reproducibility in pharmacoepidemiologic studies. Pharmacoepidemiol Drug Saf. 2019 May; 28(5):671-679. PMID: 30843303.
    Citations:    
  8. Bird ST, Toh S, Sahin L, Andrade SE, Gelperin K, Taylor L, Song J, Hampp C. Misclassification in Assessment of First Trimester In-utero Exposure to Drugs Used Proximally to Conception: the Example of Letrozole Utilization for Infertility Treatment. Am J Epidemiol. 2019 Feb 01; 188(2):418-425. PMID: 30321259.
    Citations:    Fields:    
  9. Toh S, Wellman R, Coley RY, Horgan C, Sturtevant J, Moyneur E, Janning C, Pardee R, Coleman KJ, Arterburn D, McTigue K, Anau J, Cook AJ. Combining distributed regression and propensity scores: a doubly privacy-protecting analytic method for multicenter research. Clin Epidemiol. 2018; 10:1773-1786. PMID: 30568510.
    Citations:    
  10. Eworuke E, Panucci G, Goulding M, Neuner R, Toh S. Use of tumor necrosis factor-alpha inhibitors during pregnancy among women who delivered live born infants. Pharmacoepidemiol Drug Saf. 2019 Mar; 28(3):296-304. PMID: 30430682.
    Citations:    Fields:    
  11. Swain RS, Taylor LG, Woodworth TS, Fuller CC, Petrone AB, Menzin TJ, Haug NR, Toh S, Mosholder AD. Overall and cause-specific mortality in the Sentinel system: A power analysis. Pharmacoepidemiol Drug Saf. 2018 Dec; 27(12):1416-1421. PMID: 30421839.
    Citations:    Fields:    
  12. Li J, Panucci G, Moeny D, Liu W, Maro JC, Toh S, Huang TY. Association of Risk for Venous Thromboembolism With Use of Low-Dose Extended- and Continuous-Cycle Combined Oral Contraceptives: A Safety Study Using the Sentinel Distributed Database. JAMA Intern Med. 2018 Nov 01; 178(11):1482-1488. PMID: 30285041.
    Citations:    
  13. Desai RJ, Wyss R, Jin Y, Bohn J, Toh S, Cosgrove A, Kennedy A, Kim J, Kim C, Ouellet-Hellstrom R, Karami S, Major JM, Niman A, Wang SV, Gagne JJ. Extension of Disease Risk Score-Based Confounding Adjustments for Multiple Outcomes of Interest: An Empirical Evaluation. Am J Epidemiol. 2018 Nov 01; 187(11):2439-2448. PMID: 29947726.
    Citations:    Fields:    
  14. Block JP, Bailey LC, Gillman MW, Lunsford D, Daley MF, Eneli I, Finkelstein J, Heerman W, Horgan CE, Hsia DS, Jay M, Rao G, Reynolds JS, Rifas-Shiman SL, Sturtevant JL, Toh S, Trasande L, Young J, Forrest CB. Early Antibiotic Exposure and Weight Outcomes in Young Children. Pediatrics. 2018 12; 142(6). PMID: 30381474.
    Citations:    Fields:    
  15. Arterburn D, Wellman R, Emiliano A, Smith SR, Odegaard AO, Murali S, Williams N, Coleman KJ, Courcoulas A, Coley RY, Anau J, Pardee R, Toh S, Janning C, Cook A, Sturtevant J, Horgan C, McTigue KM. Comparative Effectiveness and Safety of Bariatric Procedures for Weight Loss: A PCORnet Cohort Study. Ann Intern Med. 2018 12 04; 169(11):741-750. PMID: 30383139.
    Citations:    Fields:    
  16. Cottreau CM, Dashevsky I, Andrade SE, Li DK, Nekhlyudov L, Raebel MA, Ritzwoller DP, Partridge AH, Pawloski PA, Toh S. Pregnancy-Associated Cancer: A U.S. Population-Based Study. J Womens Health (Larchmt). 2019 Feb; 28(2):250-257. PMID: 30307780.
    Citations:    Fields:    
  17. Mosholder AD, Taylor L, Mannheim G, Ortendahl L, Woodworth TS, Toh S. Incidence of Heart Failure and Cardiomyopathy Following Initiation of Medications for Attention-Deficit/Hyperactivity Disorder: A Descriptive Study. J Clin Psychopharmacol. 2018 Oct; 38(5):505-508. PMID: 30102629.
    Citations:    Fields:    Translation:HumansPHPublic Health
  18. Wong J, Horwitz MM, Zhou L, Toh S. Using machine learning to identify health outcomes from electronic health record data. Curr Epidemiol Rep. 2018 Dec; 5(4):331-342. PMID: 30555773.
    Citations:    
  19. Sun JW, Rogers JR, Her Q, Welch EC, Panozzo CA, Toh S, Gagne JJ. Validation of the Combined Comorbidity Index of Charlson and Elixhauser to Predict 30-Day Mortality Across ICD-9 and ICD-10. Med Care. 2018 09; 56(9):812. PMID: 30001251.
    Citations:    Fields:    
  20. Ball R, Toh S, Nolan J, Haynes K, Forshee R, Botsis T. Evaluating automated approaches to anaphylaxis case classification using unstructured data from the FDA Sentinel System. Pharmacoepidemiol Drug Saf. 2018 10; 27(10):1077-1084. PMID: 30152575.
    Citations:    Fields:    
  21. Cocoros NM, Panucci G, Haug N, Maher C, Reichman M, Toh S. Outpatient influenza antivirals in a distributed data network for influenza surveillance. Influenza Other Respir Viruses. 2018 11; 12(6):804-807. PMID: 30053342.
    Citations:    Fields:    
  22. Yoshida K, Gruber S, Fireman BH, Toh S. Comparison of privacy-protecting analytic and data-sharing methods: A simulation study. Pharmacoepidemiol Drug Saf. 2018 09; 27(9):1034-1041. PMID: 30022561.
    Citations:    Fields:    
  23. Panozzo CA, Welch EC, Woodworth TS, Huang TY, Her QL, Gagne JJ, Sun JW, Rogers C, Menzin TJ, Ehrmann M, Freitas KE, Haug NR, Toh S. Assessing the impact of the new ICD-10-CM coding system on pharmacoepidemiologic studies-An application to the known association between angiotensin-converting enzyme inhibitors and angioedema. Pharmacoepidemiol Drug Saf. 2018 08; 27(8):829-838. PMID: 29947045.
    Citations:    Fields:    
  24. Panozzo CA, Woodworth TS, Welch EC, Huang TY, Her QL, Haynes K, Rogers C, Menzin TJ, Ehrmann M, Freitas KE, Haug NR, Toh S. Early impact of the ICD-10-CM transition on selected health outcomes in 13 electronic health care databases in the United States. Pharmacoepidemiol Drug Saf. 2018 08; 27(8):839-847. PMID: 29947033.
    Citations:    Fields:    
  25. Her QL, Malenfant JM, Malek S, Vilk Y, Young J, Li L, Brown J, Toh S. A Query Workflow Design to Perform Automatable Distributed Regression Analysis in Large Distributed Data Networks. EGEMS (Wash DC). 2018 May 25; 6(1):11. PMID: 30094283.
    Citations:    
  26. Lu CY, Penfold RB, Toh S, Sturtevant JL, Madden JM, Simon G, Ahmedani BK, Clarke G, Coleman KJ, Copeland LA, Daida YG, Davis RL, Hunkeler EM, Owen-Smith A, Raebel MA, Rossom R, Soumerai SB, Kulldorff M. Near Real-time Surveillance for Consequences of Health Policies Using Sequential Analysis. Med Care. 2018 05; 56(5):365-372. PMID: 29634627.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  27. Inge TH, Coley RY, Bazzano LA, Xanthakos SA, McTigue K, Arterburn D, Williams N, Wellman R, Coleman KJ, Courcoulas A, Desai NK, Anau J, Pardee R, Toh S, Janning C, Cook A, Sturtevant J, Horgan C, Zebrick AJ, Michalsky M. Comparative effectiveness of bariatric procedures among adolescents: the PCORnet bariatric study. Surg Obes Relat Dis. 2018 Sep; 14(9):1374-1386. PMID: 29793877.
    Citations:    Fields:    
  28. Li X, Lund JL, Toh S. Lower Cancer Incidence-Warfarin Effect or Immortal Time Bias? JAMA Intern Med. 2018 04 01; 178(4):584-585. PMID: 29610881.
    Citations:    Fields:    
  29. Dong YH, Chang CH, Wu LC, Hwang JS, Toh S. Comparative cardiovascular safety of nonsteroidal anti-inflammatory drugs in patients with hypertension: a population-based cohort study. Br J Clin Pharmacol. 2018 05; 84(5):1045-1056. PMID: 29468706.
    Citations: 1     Fields:    
  30. Carnahan RM, Kuntz JL, Wang SV, Fuller C, Gagne JJ, Leonard CE, Hennessy S, Meyer T, Archdeacon P, Chen CY, Panozzo CA, Toh S, Katcoff H, Woodworth T, Iyer A, Axtman S, Chrischilles EA. Evaluation of the US Food and Drug Administration sentinel analysis tools in confirming previously observed drug-outcome associations: The case of clindamycin and Clostridium difficile infection. Pharmacoepidemiol Drug Saf. 2018 07; 27(7):731-739. PMID: 29532543.
    Citations:    Fields:    
  31. Illoh OA, Toh S, Andrade SE, Hampp C, Sahin L, Gelperin K, Taylor L, Bird ST. Utilization of drugs with pregnancy exposure registries during pregnancy. Pharmacoepidemiol Drug Saf. 2018 06; 27(6):604-611. PMID: 29516585.
    Citations: 1     Fields:    
  32. Martin D, Gagne JJ, Gruber S, Izem R, Nelson JC, Nguyen MD, Ouellet-Hellstrom R, Schneeweiss S, Toh S, Walker AM. Sequential surveillance for drug safety in a regulatory environment. Pharmacoepidemiol Drug Saf. 2018 07; 27(7):707-712. PMID: 29504168.
    Citations: 1     Fields:    
  33. Chrischilles EA, Gagne JJ, Fireman B, Nelson J, Toh S, Shoaibi A, Reichman ME, Wang S, Nguyen M, Zhang R, Izem R, Goulding MR, Southworth MR, Graham DJ, Fuller C, Katcoff H, Woodworth T, Rogers C, Saliga R, Lin ND, McMahill-Walraven CN, Nair VP, Haynes K, Carnahan RM. Prospective surveillance pilot of rivaroxaban safety within the US Food and Drug Administration Sentinel System. Pharmacoepidemiol Drug Saf. 2018 03; 27(3):263-271. PMID: 29318683.
    Citations:    Fields:    
  34. Bird ST, Gelperin K, Taylor L, Sahin L, Hammad H, Andrade SE, Mohamoud MA, Toh S, Hampp C. Enrollment and Retention in 34 United States Pregnancy Registries Contrasted with the Manufacturer's Capture of Spontaneous Reports for Exposed Pregnancies. Drug Saf. 2018 01; 41(1):87-94. PMID: 28840499.
    Citations: 2     Fields:    Translation:Humans
  35. Toh S, Rasmussen-Torvik LJ, Harmata EE, Pardee R, Saizan R, Malanga E, Sturtevant JL, Horgan CE, Anau J, Janning CD, Wellman RD, Coley RY, Cook AJ, Courcoulas AP, Coleman KJ, Williams NA, McTigue KM, Arterburn D, McClay J. The National Patient-Centered Clinical Research Network (PCORnet) Bariatric Study Cohort: Rationale, Methods, and Baseline Characteristics. JMIR Res Protoc. 2017 Dec 05; 6(12):e222. PMID: 29208590.
    Citations:    
  36. Sun JW, Rogers JR, Her Q, Welch EC, Panozzo CA, Toh S, Gagne JJ. Adaptation and Validation of the Combined Comorbidity Score for ICD-10-CM. Med Care. 2017 12; 55(12):1046-1051. PMID: 29087983.
    Citations:    Fields:    Translation:Humans
  37. Go AS, Singer DE, Toh S, Cheetham TC, Reichman ME, Graham DJ, Southworth MR, Zhang R, Izem R, Goulding MR, Houstoun M, Mott K, Sung SH, Gagne JJ. Outcomes of Dabigatran and Warfarin for Atrial Fibrillation in Contemporary Practice: A Retrospective Cohort Study. Ann Intern Med. 2017 Dec 19; 167(12):845-854. PMID: 29132153.
    Citations: 1     Fields:    Translation:Humans
  38. Toh S, Reichman ME, Graham DJ, Hampp C, Zhang R, Butler MG, Iyer A, Rucker M, Pimentel M, Hamilton J, Lendle S, Fireman BH. Prospective Postmarketing Surveillance of Acute Myocardial Infarction in New Users of Saxagliptin: A Population-Based Study. Diabetes Care. 2018 01; 41(1):39-48. PMID: 29122893.
    Citations:    Fields:    Translation:Humans
  39. Gagne JJ, Houstoun M, Reichman ME, Hampp C, Marshall JH, Toh S. Safety assessment of niacin in the US Food and Drug Administration's mini-sentinel system. Pharmacoepidemiol Drug Saf. 2018 01; 27(1):30-37. PMID: 29108128.
    Citations:    Fields:    
  40. Zhou M, Wang SV, Leonard CE, Gagne JJ, Fuller C, Hampp C, Archdeacon P, Toh S, Iyer A, Woodworth TS, Cavagnaro E, Panozzo CA, Axtman S, Carnahan RM, Chrischilles EA, Hennessy S. Sentinel Modular Program for Propensity Score-Matched Cohort Analyses: Application to Glyburide, Glipizide, and Serious Hypoglycemia. Epidemiology. 2017 11; 28(6):838-846. PMID: 28682851.
    Citations: 6     Fields:    Translation:HumansPHPublic Health
  41. Toh S. Pharmacoepidemiology in the era of real-world evidence. Curr Epidemiol Rep. 2017 Dec; 4(4):262-265. PMID: 29204331.
    Citations:    
  42. Li X, Young JG, Toh S. Estimating Effects of Dynamic Treatment Strategies in Pharmacoepidemiologic Studies with Time-varying Confounding: A Primer. Curr Epidemiol Rep. 2017 Dec; 4(4):288-297. PMID: 29204332.
    Citations:    
  43. Baker MA, Butler MG, Seymour S, Zhang F, Wu Y, Wu AC, Levenson MS, Wu P, Iyer A, Toh S, Iyasu S, Zhou EH. The impact of FDA regulatory activities on incident dispensing of LABA-containing medication: 2005-2011. J Asthma. 2018 Aug; 55(8):907-914. PMID: 28910559.
    Citations:    Fields:    
  44. Connolly JG, Wang SV, Fuller CC, Toh S, Panozzo CA, Cocoros N, Zhou M, Gagne JJ, Maro JC. Development and application of two semi-automated tools for targeted medical product surveillance in a distributed data network. Curr Epidemiol Rep. 2017 Dec; 4(4):298-306. PMID: 29204333.
    Citations: 1     
  45. Wang SV, Schneeweiss S, Berger ML, Brown J, de Vries F, Douglas I, Gagne JJ, Gini R, Klungel O, Mullins CD, Nguyen MD, Rassen JA, Smeeth L, Sturkenboom M. Reporting to Improve Reproducibility and Facilitate Validity Assessment for Healthcare Database Studies V1.0. Pharmacoepidemiol Drug Saf. 2017 09; 26(9):1018-1032. PMID: 28913963.
    Citations: 7     Fields:    Translation:Humans
  46. Mazor KM, Richards A, Gallagher M, Arterburn DE, Raebel MA, Nowell WB, Curtis JR, Paolino AR, Toh S. Stakeholders' views on data sharing in multicenter studies. J Comp Eff Res. 2017 Sep; 6(6):537-547. PMID: 28805448.
    Citations: 1     Fields:    
  47. Lu CY, Williams MS, Ginsburg GS, Toh S, Brown JS, Khoury MJ. A proposed approach to accelerate evidence generation for genomic-based technologies in the context of a learning health system. Genet Med. 2018 Apr; 20(4):390-396. PMID: 28796238.
    Citations: 1     Fields:    Translation:Humans
  48. Goto T, Faridi MK, Gibo K, Toh S, Hanania NA, Camargo CA, Hasegawa K. Trends in 30-day readmission rates after COPD hospitalization, 2006-2012. Respir Med. 2017 Sep; 130:92-97. PMID: 29206640.
    Citations: 2     Fields:    Translation:Humans
  49. Andrade SE, Bérard A, Nordeng HME, Wood ME, van Gelder MMHJ, Toh S. Administrative Claims Data Versus Augmented Pregnancy Data for the Study of Pharmaceutical Treatments in Pregnancy. Curr Epidemiol Rep. 2017; 4(2):106-116. PMID: 29399433.
    Citations:    
  50. Taylor LG, Bird ST, Sahin L, Tassinari MS, Greene P, Reichman ME, Andrade SE, Haffenreffer K, Toh S. Antiemetic use among pregnant women in the United States: the escalating use of ondansetron. Pharmacoepidemiol Drug Saf. 2017 May; 26(5):592-596. PMID: 28220993.
    Citations: 1     Fields:    Translation:Humans
  51. Tan EC, Bell JS, Lu CY, Toh S. National Trends in Outpatient Antihypertensive Prescribing in People with Dementia in the United States. J Alzheimers Dis. 2016 10 18; 54(4):1425-1435. PMID: 27589531.
    Citations:    Fields:    Translation:Humans
  52. Gagne JJ, Han X, Hennessy S, Leonard CE, Chrischilles EA, Carnahan RM, Wang SV, Fuller C, Iyer A, Katcoff H, Woodworth TS, Archdeacon P, Meyer TE, Schneeweiss S, Toh S. Successful Comparison of US Food and Drug Administration Sentinel Analysis Tools to Traditional Approaches in Quantifying a Known Drug-Adverse Event Association. Clin Pharmacol Ther. 2016 Nov; 100(5):558-564. PMID: 27416001.
    Citations: 6     Fields:    Translation:Humans
  53. Gruber S, Chakravarty A, Heckbert SR, Levenson M, Martin D, Nelson JC, Psaty BM, Pinheiro S, Reich CG, Toh S, Walker AM. Design and analysis choices for safety surveillance evaluations need to be tuned to the specifics of the hypothesized drug-outcome association. Pharmacoepidemiol Drug Saf. 2016 09; 25(9):973-81. PMID: 27418432.
    Citations: 3     Fields:    Translation:Humans
  54. Andrade SE, Reichman ME, Mott K, Pitts M, Kieswetter C, Dinatale M, Stone MB, Popovic J, Haffenreffer K, Toh S. Use of selective serotonin reuptake inhibitors (SSRIs) in women delivering liveborn infants and other women of child-bearing age within the U.S. Food and Drug Administration's Mini-Sentinel program. Arch Womens Ment Health. 2016 12; 19(6):969-977. PMID: 27178125.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  55. Mott K, Graham DJ, Toh S, Gagne JJ, Levenson M, Ma Y, Reichman ME. Uptake of new drugs in the early post-approval period in the Mini-Sentinel distributed database. Pharmacoepidemiol Drug Saf. 2016 09; 25(9):1023-32. PMID: 27146123.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  56. Toh S, Hampp C, Reichman ME, Graham DJ, Balakrishnan S, Pucino F, Hamilton J, Lendle S, Iyer A, Rucker M, Pimentel M, Nathwani N, Griffin MR, Brown NJ, Fireman BH. Risk for Hospitalized Heart Failure Among New Users of Saxagliptin, Sitagliptin, and Other Antihyperglycemic Drugs: A Retrospective Cohort Study. Ann Intern Med. 2016 Jun 07; 164(11):705-14. PMID: 27110660.
    Citations: 15     Fields:    Translation:Humans
  57. Andrade SE, Toh S, Houstoun M, Mott K, Pitts M, Kieswetter C, Ceresa C, Haffenreffer K, Reichman ME. Surveillance of Medication Use During Pregnancy in the Mini-Sentinel Program. Matern Child Health J. 2016 Apr; 20(4):895-903. PMID: 26645616.
    Citations: 3     Fields:    Translation:Humans
  58. Butler MG, Zhou EH, Zhang F, Wu YT, Wu AC, Levenson MS, Wu P, Seymour S, Toh S, Iyer A, Iyasu S, Baker MA. Changing patterns of asthma medication use related to US Food and Drug Administration long-acting ß2-agonist regulation from 2005-2011. J Allergy Clin Immunol. 2016 Mar; 137(3):710-7. PMID: 26725997.
    Citations: 1     Fields:    Translation:Humans
  59. Hansen C, Andrade SE, Freiman H, Dublin S, Haffenreffer K, Cooper WO, Cheetham TC, Toh S, Li DK, Raebel MA, Kuntz JL, Perrin N, Rosales AG, Carter S, Pawloski PA, Maloney EM, Graham DJ, Sahin L, Scott PE, Yap J, Davis R. Trimethoprim-sulfonamide use during the first trimester of pregnancy and the risk of congenital anomalies. Pharmacoepidemiol Drug Saf. 2016 Feb; 25(2):170-8. PMID: 26599424.
    Citations: 3     Fields:    Translation:Humans
  60. Cameron C, Fireman B, Hutton B, Clifford T, Coyle D, Wells G, Dormuth CR, Platt R, Toh S. Network meta-analysis incorporating randomized controlled trials and non-randomized comparative cohort studies for assessing the safety and effectiveness of medical treatments: challenges and opportunities. Syst Rev. 2015 Nov 05; 4:147. PMID: 26537988.
    Citations: 13     Fields:    Translation:Humans
  61. Guidelines for good pharmacoepidemiology practice (GPP). Pharmacoepidemiol Drug Saf. 2016 Jan; 25(1):2-10. PMID: 26537534.
    Citations: 8     Fields:    Translation:Humans
  62. Arterburn D, Powers JD, Toh S, Polsky S, Butler MG, Portz JD, Donahoo WT, Herrinton L, Williams RJ, Vijayadeva V, Fisher D, Bayliss EA. Comparative effectiveness of laparoscopic adjustable gastric banding vs laparoscopic gastric bypass. JAMA Surg. 2014 Dec; 149(12):1279-87. PMID: 25353723.
    Citations: 8     Fields:    Translation:Humans
  63. Dublin S, Johnson KE, Walker RL, Avalos LA, Andrade SE, Beaton SJ, Davis RL, Herrinton LJ, Pawloski PA, Raebel MA, Smith DH, Toh S, Caughey AB. Trends in elective labor induction for six United States health plans, 2001-2007. J Womens Health (Larchmt). 2014 Nov; 23(11):904-11. PMID: 25330378.
    Citations: 1     Fields:    Translation:Humans
  64. Bell C, Chakravarty A, Gruber S, Heckbert SR, Levenson M, Martin D, Nelson JC, Pinheiro S, Psaty BM, Reich CG, Schneeweiss S, Shoaibi A, Toh S, Walker AM. Characteristics of study design and elements that may contribute to the success of electronic safety monitoring systems. Pharmacoepidemiol Drug Saf. 2014 Nov; 23(11):1223-5. PMID: 25263307.
    Citations:    Fields:    Translation:Humans
  65. Garabedian LF, Chu P, Toh S, Zaslavsky AM, Soumerai SB. Potential bias of instrumental variable analyses for observational comparative effectiveness research. Ann Intern Med. 2014 Jul 15; 161(2):131-8. PMID: 25023252.
    Citations: 30     Fields:    Translation:Humans
  66. Toh S, Shetterly S, Powers JD, Arterburn D. Privacy-preserving analytic methods for multisite comparative effectiveness and patient-centered outcomes research. Med Care. 2014 Jul; 52(7):664-8. PMID: 24926715.
    Citations: 6     Fields:    Translation:Humans
  67. Raebel MA, Newcomer SR, Bayliss EA, Boudreau D, DeBar L, Elliott TE, Ahmed AT, Pawloski PA, Fisher D, Toh S, Donahoo WT. Chronic opioid use emerging after bariatric surgery. Pharmacoepidemiol Drug Saf. 2014 Dec; 23(12):1247-57. PMID: 24733580.
    Citations: 6     Fields:    Translation:Humans
  68. Bussing R, Narwaney KJ, Winterstein AG, Newton DA, DeBar L, Boscarino JA, Toh S, Pawloski P, Nordin JD, Herrinton LJ, Mason D, Daley MF. Pharmacotherapy for incident attention-deficit/hyperactivity disorder: practice patterns and quality metrics. Curr Med Res Opin. 2014 Aug; 30(8):1687-99. PMID: 24635013.
    Citations: 1     Fields:    Translation:Humans
  69. Toh S, Avorn J, D'Agostino RB, Gurwitz JH, Psaty BM, Rothman KJ, Saag KG, Sturkenboom MC, Vandenbroucke JP, Winterstein AG, Strom BL. RE: Drug risk assessment and data reuse. Pharmacoepidemiol Drug Saf. 2014 Jan; 23(1):109-10. PMID: 24395550.
    Citations:    Fields:    Translation:Humans
  70. Briesacher BA, Soumerai SB, Zhang F, Toh S, Andrade SE, Wagner JL, Shoaibi A, Gurwitz JH. Response to the letter by Mol. Pharmacoepidemiol Drug Saf. 2014 Jan; 23(1):106. PMID: 24395548.
    Citations:    Fields:    Translation:PHPublic Health
  71. Avalos LA, Chen H, Yang C, Andrade SE, Cooper WO, Cheetham CT, Davis RL, Dublin S, Hammad TA, Kaplan S, Pawloski PA, Raebel MA, Scott PE, Smith DH, Toh S, Li DK. The prevalence and trends of antiviral medication use during pregnancy in the US: a population-based study of 664,297 deliveries in 2001-2007. Matern Child Health J. 2014 Jan; 18(1):64-72. PMID: 23420306.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  72. Daley MF, Newton DA, DeBar L, Newcomer SR, Pieper L, Boscarino JA, Toh S, Pawloski P, Nordin JD, Nakasato C, Herrinton LJ, Bussing R. Accuracy of Electronic Health Record-Derived Data for the Identification of Incident ADHD. J Atten Disord. 2017 03; 21(5):416-425. PMID: 24510475.
    Citations:    Fields:    Translation:Humans
  73. Toh S, Manson JE. An analytic framework for aligning observational and randomized trial data: Application to postmenopausal hormone therapy and coronary heart disease. Stat Biosci. 2013 Nov 01; 5(2). PMID: 24244222.
    Citations: 5     
  74. Toh S, Platt R. Big data in epidemiology: too big to fail? Epidemiology. 2013 Nov; 24(6):939. PMID: 24077001.
    Citations: 3     Fields:    Translation:Humans
  75. Hansen C, Joski P, Freiman H, Andrade S, Toh S, Dublin S, Cheetham C, Cooper W, Pawloski P, Li DK, Beaton S, Kaplan S, Scott P, Hammad T, Davis R. Medication exposure in pregnancy risk evaluation program: the prevalence of asthma medication use during pregnancy. Matern Child Health J. 2013 Nov; 17(9):1611-21. PMID: 23108737.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  76. Kim SC, Gillet VG, Feldman S, Lii H, Toh S, Brown JS, Katz JN, Solomon DH, Schneeweiss S. Validation of claims-based algorithms for identification of high-grade cervical dysplasia and cervical cancer. Pharmacoepidemiol Drug Saf. 2013 Nov; 22(11):1239-44. PMID: 24027140.
    Citations: 4     Fields:    Translation:Humans
  77. Toh S, Avorn J, D'Agostino RB, Gurwitz JH, Psaty BM, Rothman KJ, Saag KG, Sturkenboom MC, Vandenbroucke JP, Winterstein AG, Strom BL. Re-using Mini-Sentinel data following rapid assessments of potential safety signals via modular analytic programs. Pharmacoepidemiol Drug Saf. 2013 Oct; 22(10):1036-45. PMID: 23922322.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  78. Brown JS, Kahn M, Toh S. Data quality assessment for comparative effectiveness research in distributed data networks. Med Care. 2013 Aug; 51(8 Suppl 3):S22-9. PMID: 23793049.
    Citations: 26     Fields:    Translation:Humans
  79. Toh S, Gagne JJ, Rassen JA, Fireman BH, Kulldorff M, Brown JS. Confounding adjustment in comparative effectiveness research conducted within distributed research networks. Med Care. 2013 Aug; 51(8 Suppl 3):S4-10. PMID: 23752258.
    Citations: 20     Fields:    Translation:Humans
  80. Toh S, Reichman ME, Houstoun M, Ding X, Fireman BH, Gravel E, Levenson M, Li L, Moyneur E, Shoaibi A, Zornberg G, Hennessy S. Multivariable confounding adjustment in distributed data networks without sharing of patient-level data. Pharmacoepidemiol Drug Saf. 2013 Nov; 22(11):1171-7. PMID: 23878013.
    Citations: 10     Fields:    Translation:Humans
  81. Briesacher BA, Soumerai SB, Zhang F, Toh S, Andrade SE, Wagner JL, Shoaibi A, Gurwitz JH. A critical review of methods to evaluate the impact of FDA regulatory actions. Pharmacoepidemiol Drug Saf. 2013 Sep; 22(9):986-94. PMID: 23847020.
    Citations: 6     Fields:    Translation:PHPublic Health
  82. Lo Re V, Haynes K, Goldberg D, Forde KA, Carbonari DM, Leidl KB, Hennessy S, Reddy KR, Pawloski PA, Daniel GW, Cheetham TC, Iyer A, Coughlin KO, Toh S, Boudreau DM, Selvam N, Cooper WO, Selvan MS, VanWormer JJ, Avigan MI, Houstoun M, Zornberg GL, Racoosin JA, Shoaibi A. Validity of diagnostic codes to identify cases of severe acute liver injury in the US Food and Drug Administration's Mini-Sentinel Distributed Database. Pharmacoepidemiol Drug Saf. 2013 Aug; 22(8):861-72. PMID: 23801638.
    Citations: 20     Fields:    Translation:Humans
  83. Toh S, Baker MA, Brown JS, Kornegay C, Platt R. Rapid assessment of cardiovascular risk among users of smoking cessation drugs within the US Food and Drug Administration's Mini-Sentinel program. JAMA Intern Med. 2013 May 13; 173(9):817-9. PMID: 23529063.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  84. Toh S, Platt R. Is size the next big thing in epidemiology? Epidemiology. 2013 May; 24(3):349-51. PMID: 23549179.
    Citations: 14     Fields:    Translation:Humans
  85. Johnson KE, Beaton SJ, Andrade SE, Cheetham TC, Scott PE, Hammad TA, Dashevsky I, Cooper WO, Davis RL, Pawloski PA, Raebel MA, Smith DH, Toh S, Li DK, Haffenreffer K, Dublin S. Methods of linking mothers and infants using health plan data for studies of pregnancy outcomes. Pharmacoepidemiol Drug Saf. 2013 Jul; 22(7):776-82. PMID: 23596095.
    Citations: 5     Fields:    Translation:Humans
  86. Toh S, Li Q, Cheetham TC, Cooper WO, Davis RL, Dublin S, Hammad TA, Li DK, Pawloski PA, Pinheiro SP, Raebel MA, Scott PE, Smith DH, Bobo WV, Lawrence JM, Dashevsky I, Haffenreffer K, Avalos LA, Andrade SE. Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001-2007: a population-based study of 585,615 deliveries. Arch Womens Ment Health. 2013 Apr; 16(2):149-57. PMID: 23389622.
    Citations: 18     Fields:    Translation:HumansPHPublic Health
  87. Li Q, Andrade SE, Cooper WO, Davis RL, Dublin S, Hammad TA, Pawloski PA, Pinheiro SP, Raebel MA, Scott PE, Smith DH, Dashevsky I, Haffenreffer K, Johnson KE, Toh S. Validation of an algorithm to estimate gestational age in electronic health plan databases. Pharmacoepidemiol Drug Saf. 2013 May; 22(5):524-32. PMID: 23335117.
    Citations: 13     Fields:    Translation:Humans
  88. Lawrence JM, Andrade SE, Avalos LA, Beaton SJ, Chiu VY, Davis RL, Dublin S, Pawloski PA, Raebel MA, Smith DH, Toh S, Wang JQ, Kaplan S, Amini T, Hampp C, Hammad TA, Scott PE, Cheetham TC. Prevalence, trends, and patterns of use of antidiabetic medications among pregnant women, 2001-2007. Obstet Gynecol. 2013 Jan; 121(1):106-14. PMID: 23262934.
    Citations: 7     Fields:    Translation:Humans
  89. Toh S, Reichman ME, Houstoun M, Ross Southworth M, Ding X, Hernandez AF, Levenson M, Li L, McCloskey C, Shoaibi A, Wu E, Zornberg G, Hennessy S. Comparative risk for angioedema associated with the use of drugs that target the renin-angiotensin-aldosterone system. Arch Intern Med. 2012 Nov 12; 172(20):1582-9. PMID: 23147456.
    Citations: 29     Fields:    Translation:Humans
  90. Bobo WV, Davis RL, Toh S, Li DK, Andrade SE, Cheetham TC, Pawloski P, Dublin S, Pinheiro S, Hammad T, Scott PE, Epstein RA, Arbogast PG, Morrow JA, Dudley JA, Lawrence JM, Avalos LA, Cooper WO. Trends in the use of antiepileptic drugs among pregnant women in the US, 2001-2007: a medication exposure in pregnancy risk evaluation program study. Paediatr Perinat Epidemiol. 2012 Nov; 26(6):578-88. PMID: 23061694.
    Citations: 12     Fields:    Translation:Humans
  91. Andrade SE, Davis RL, Cheetham TC, Cooper WO, Li DK, Amini T, Beaton SJ, Dublin S, Hammad TA, Pawloski PA, Raebel MA, Smith DH, Staffa JA, Toh S, Dashevsky I, Haffenreffer K, Lane K, Platt R, Scott PE. Medication Exposure in Pregnancy Risk Evaluation Program. Matern Child Health J. 2012 Oct; 16(7):1349-54. PMID: 22002179.
    Citations: 13     Fields:    Translation:HumansPHPublic Health
  92. Andrade SE, Scott PE, Davis RL, Li DK, Getahun D, Cheetham TC, Raebel MA, Toh S, Dublin S, Pawloski PA, Hammad TA, Beaton SJ, Smith DH, Dashevsky I, Haffenreffer K, Cooper WO. Validity of health plan and birth certificate data for pregnancy research. Pharmacoepidemiol Drug Saf. 2013 Jan; 22(1):7-15. PMID: 22753079.
    Citations: 20     Fields:    Translation:Humans
  93. Cutrona SL, Toh S, Iyer A, Foy S, Daniel GW, Nair VP, Ng D, Butler MG, Boudreau D, Forrow S, Goldberg R, Gore J, McManus D, Racoosin JA, Gurwitz JH. Validation of acute myocardial infarction in the Food and Drug Administration's Mini-Sentinel program. Pharmacoepidemiol Drug Saf. 2013 Jan; 22(1):40-54. PMID: 22745038.
    Citations: 16     Fields:    Translation:Humans
  94. Toh S, García Rodríguez LA, Hernán MA. Analyzing partially missing confounder information in comparative effectiveness and safety research of therapeutics. Pharmacoepidemiol Drug Saf. 2012 May; 21 Suppl 2:13-20. PMID: 22552975.
    Citations: 6     Fields:    Translation:Humans
  95. Toh S, Li L, Harrold LR, Bayliss EA, Curtis JR, Liu L, Chen L, Grijalva CG, Herrinton LJ. Comparative safety of infliximab and etanercept on the risk of serious infections: does the association vary by patient characteristics? Pharmacoepidemiol Drug Saf. 2012 May; 21(5):524-34. PMID: 22411435.
    Citations: 9     Fields:    Translation:Humans
  96. Fireman B, Toh S, Butler MG, Go AS, Joffe HV, Graham DJ, Nelson JC, Daniel GW, Selby JV. A protocol for active surveillance of acute myocardial infarction in association with the use of a new antidiabetic pharmaceutical agent. Pharmacoepidemiol Drug Saf. 2012 Jan; 21 Suppl 1:282-90. PMID: 22262618.
    Citations: 6     Fields:    Translation:Humans
  97. Platt R, Carnahan RM, Brown JS, Chrischilles E, Curtis LH, Hennessy S, Nelson JC, Racoosin JA, Robb M, Schneeweiss S, Toh S, Weiner MG. The U.S. Food and Drug Administration's Mini-Sentinel program: status and direction. Pharmacoepidemiol Drug Saf. 2012 Jan; 21 Suppl 1:1-8. PMID: 22262586.
    Citations: 70     Fields:    Translation:Humans
  98. Gagne JJ, Fireman B, Ryan PB, Maclure M, Gerhard T, Toh S, Rassen JA, Nelson JC, Schneeweiss S. Design considerations in an active medical product safety monitoring system. Pharmacoepidemiol Drug Saf. 2012 Jan; 21 Suppl 1:32-40. PMID: 22262591.
    Citations: 15     Fields:    Translation:Humans
  99. Cutrona SL, Toh S, Iyer A, Foy S, Cavagnaro E, Forrow S, Racoosin JA, Goldberg R, Gurwitz JH. Design for validation of acute myocardial infarction cases in Mini-Sentinel. Pharmacoepidemiol Drug Saf. 2012 Jan; 21 Suppl 1:274-81. PMID: 22262617.
    Citations: 10     Fields:    Translation:Humans
  100. Toh S, Platt R, Steiner JF, Brown JS. Comparative-effectiveness research in distributed health data networks. Clin Pharmacol Ther. 2011 Dec; 90(6):883-7. PMID: 22030567.
    Citations: 17     Fields:    Translation:Humans
  101. Andrade SE, Moore Simas TA, Boudreau D, Raebel MA, Toh S, Syat B, Dashevsky I, Platt R. Validation of algorithms to ascertain clinical conditions and medical procedures used during pregnancy. Pharmacoepidemiol Drug Saf. 2011 Nov; 20(11):1168-76. PMID: 22020902.
    Citations: 9     Fields:    Translation:Humans
  102. Chen SY, Toh S. National trends in prescribing antidepressants before and after an FDA advisory on suicidality risk in youths. Psychiatr Serv. 2011 Jul; 62(7):727-33. PMID: 21724784.
    Citations: 5     Fields:    Translation:Humans
  103. Toh S, García Rodríguez LA, Hernán MA. Confounding adjustment via a semi-automated high-dimensional propensity score algorithm: an application to electronic medical records. Pharmacoepidemiol Drug Saf. 2011 Aug; 20(8):849-57. PMID: 21717528.
    Citations: 22     Fields:    Translation:Humans
  104. Chang CH, Toh S, Lin JW, Chen ST, Kuo CW, Chuang LM, Lai MS. Cancer risk associated with insulin glargine among adult type 2 diabetes patients--a nationwide cohort study. PLoS One. 2011; 6(6):e21368. PMID: 21738645.
    Citations: 25     Fields:    Translation:Humans
  105. Toh S, Mitchell AA, Anderka M, de Jong-van den Berg LT, Hernández-Díaz S. Antibiotics and oral contraceptive failure - a case-crossover study. Contraception. 2011 May; 83(5):418-25. PMID: 21477683.
    Citations: 5     Fields:    Translation:Humans
  106. Toh S, Hernández-Díaz S, Logan R, Robins JM, Hernán MA. Estimating absolute risks in the presence of nonadherence: an application to a follow-up study with baseline randomization. Epidemiology. 2010 Jul; 21(4):528-39. PMID: 20526200.
    Citations: 24     Fields:    Translation:Humans
  107. Toh S, Hernández-Díaz S, Logan R, Rossouw JE, Hernán MA. Coronary heart disease in postmenopausal recipients of estrogen plus progestin therapy: does the increased risk ever disappear? A randomized trial. Ann Intern Med. 2010 Feb 16; 152(4):211-7. PMID: 20157135.
    Citations: 24     Fields:    Translation:Humans
  108. Toh S, Mitchell AA, Louik C, Werler MM, Chambers CD, Hernández-Díaz S. Antidepressant use during pregnancy and the risk of preterm delivery and fetal growth restriction. J Clin Psychopharmacol. 2009 Dec; 29(6):555-60. PMID: 19910720.
    Citations: 16     Fields:    Translation:Humans
  109. Hernández-Díaz S, Toh S, Cnattingius S. Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study. BMJ. 2009 Jun 18; 338:b2255. PMID: 19541696.
    Citations: 74     Fields:    Translation:Humans
  110. Toh S, Mitchell AA, Louik C, Werler MM, Chambers CD, Hernández-Díaz S. Selective serotonin reuptake inhibitor use and risk of gestational hypertension. Am J Psychiatry. 2009 Mar; 166(3):320-8. PMID: 19122006.
    Citations: 22     Fields:    Translation:Humans
  111. Toh S, Hernán MA. Causal inference from longitudinal studies with baseline randomization. Int J Biostat. 2008 Oct 19; 4(1):Article 22. PMID: 20231914.
    Citations: 26     Fields:    Translation:Humans
  112. Toh S, Mitchell AA, Werler MM, Hernández-Díaz S. Sensitivity and specificity of computerized algorithms to classify gestational periods in the absence of information on date of conception. Am J Epidemiol. 2008 Mar 15; 167(6):633-40. PMID: 18194999.
    Citations: 21     Fields:    Translation:Humans
  113. Toh S, Rodríguez LA, Hernández-Díaz S. Use of antidepressants and risk of lung cancer. Cancer Causes Control. 2007 Dec; 18(10):1055-64. PMID: 17682831.
    Citations: 8     Fields:    Translation:Humans
  114. Toh S, Hernández-Díaz S. Statins and fracture risk. A systematic review. Pharmacoepidemiol Drug Saf. 2007 Jun; 16(6):627-40. PMID: 17286319.
    Citations: 17     Fields:    Translation:HumansAnimals
  115. Toh S. Datapoints: trends in ADHD and stimulant use among children, 1993-2003. Psychiatr Serv. 2006 Aug; 57(8):1091. PMID: 16870957.
    Citations: 4     Fields:    Translation:Humans
  116. Lin SJ, Lambert BL, Tan H, Toh S. Frequency estimates from prescription drug datasets. Pharmacoepidemiol Drug Saf. 2005; 15:512-520.
  117. Ring D, Jupiter JB, Toh S. Transarticular bony defects after trauma and sepsis: arthrodesis using vascularized fibular transfer. Plast Reconstr Surg. 1999 Aug; 104(2):426-34. PMID: 10654686.
    Citations: 3     Fields:    Translation:Humans
  118. Ring D, Jupiter JB, Toh S. Salvage of contaminated fractures of the distal humerus with thin wire external fixation. Clin Orthop Relat Res. 1999 Feb; (359):203-8. PMID: 10078144.
    Citations: 1     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.