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Sengwee Darren Toh, D.S.

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Overview
Darren Toh, ScD is Professor in the Department of Population Medicine at Harvard Medical School and Harvard Pilgrim Health Care Institute. He is a pharmacoepidemiologist with an interest in the comparative safety and effectiveness research of medical products. His research focuses on 1) assessing the risks and benefits of medical products using electronic data collected as part of routine healthcare delivery, and 2) developing and applying privacy-protecting analytic methods to conduct multi-center studies in distributed data networks.

Darren is Chief Scientist at the Operations Center of the FDA-funded Sentinel System, a congressionally mandated national medical product safety surveillance system. He is Principal Investigator of projects funded by the National Institutes of Health (U01EB023683), the Agency for Healthcare Research and Quality (R01HS026214), the Patient-Centered Outcomes Research Institute (ME-1403-11305), and the Food and Drug Administration. Darren received his doctoral degree in Epidemiology from the Harvard School of Public Health.

Mentoring
Available: 06/01/22, Expires: 06/01/23

Embedded pragmatic clinical trials (ePCTs) are an appealing and efficient approach to compare the real-world effectiveness and safety of different pharmacotherapies, but the success of such ePCTs largely hinges on the ability to reliably recruit, randomize, and retain patients. Our team studies the use of approved (on-label) and unapproved (off-label) medications for insomnia, and we are conducting a study to better understand barriers and facilitators to physicians and patients participating in ePCTs where the pharmacologic treatment for insomnia is randomized. This qualitative project will involve conducting and analyzing data from surveys, semi-structured interviews, and focus groups with physicians and patients with insomnia. Interested students will have the opportunity to participate in the data collection and analysis process, preferably as an HMS Scholarly Project. Prior experience in qualitative research is ideal, though not required. The findings from this project will help inform the design of future ePCTs involving insomnia pharmacotherapies to ensure that the design of such trials is sensitive to and adequately addresses the concerns of patients and physicians.


Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sun JW, Wang R, Li D, Toh S. Use of Linked Databases for Improved Confounding Control: Considerations for Potential Selection Bias. Am J Epidemiol. 2022 Mar 24; 191(4):711-723. PMID: 35015823.
    Citations:    Fields:    
  2. Yang Z, Toh S, Li X, Edwards D, Brayne C, Mant J. Statin use is associated with lower risk of dementia in stroke patients: a community-based cohort study with inverse probability weighted marginal structural model analysis. Eur J Epidemiol. 2022 Mar 19. PMID: 35305172.
    Citations:    Fields:    
  3. Li D, Lu W, Shu D, Toh S, Wang R. Distributed Cox proportional hazards regression using summary-level information. Biostatistics. 2022 Feb 23. PMID: 35195675.
    Citations:    Fields:    
  4. Taylor LG, Bird ST, Stojanovic D, Toh S, Maro JC, Fazio-Eynullayeva E, Petrone AB, Rajbhandari R, Andrade SE, Haynes K, McMahill-Walraven CN, Shinde M, Lyons JG. Utility of fertility procedures and prenatal tests to estimate gestational age for live-births and stillbirths in electronic health plan databases. Pharmacoepidemiol Drug Saf. 2022 May; 31(5):534-545. PMID: 35122354.
    Citations:    Fields:    
  5. Htoo PT, Measer G, Orr R, Bohn J, Sorbello A, Francis H, Dutcher SK, Cosgrove A, Carruth A, Toh S, Cocoros NM. Evaluating confounding control in estimations of influenza antiviral effectiveness in electronic health plan data. Am J Epidemiol. 2022 Feb 02. PMID: 35106530.
    Citations:    Fields:    
  6. Coughlin JW, Nauman E, Wellman R, Coley RY, McTigue KM, Coleman KJ, Jones DB, Lewis K, Tobin JN, Wee CC, Fitzpatrick SL, Desai JR, Murali S, Morrow EH, Rogers AM, Wood GC, Schlundt DG, Apovian CM, Duke MC, McClay JC, Soans R, Nemr R, Williams N, Courcoulas A, Holmes JH, Anau J, Toh S, Sturtevant JL, Horgan CE, Cook AJ, Arterburn DE. Preoperative Depression Status and Five Year Metabolic and Bariatric Surgery Outcomes in the PCORnet Bariatric Study Cohort. Ann Surg. 2022 Jan 19. PMID: 35058404.
    Citations:    Fields:    
  7. Kluberg SA, Hou L, Dutcher SK, Billings M, Kit B, Toh S, Dublin S, Haynes K, Kline A, Maiyani M, Pawloski PA, Watson ES, Cocoros NM. Validation of diagnosis codes to identify hospitalized COVID-19 patients in health care claims data. Pharmacoepidemiol Drug Saf. 2022 04; 31(4):476-480. PMID: 34913208.
    Citations:    Fields:    
  8. Desai RJ, Matheny ME, Johnson K, Marsolo K, Curtis LH, Nelson JC, Heagerty PJ, Maro J, Brown J, Toh S, Nguyen M, Ball R, Dal Pan G, Wang SV, Gagne JJ, Schneeweiss S. Broadening the reach of the FDA Sentinel system: A roadmap for integrating electronic health record data in a causal analysis framework. NPJ Digit Med. 2021 Dec 20; 4(1):170. PMID: 34931012.
    Citations:    
  9. Fu M, Naci H, Booth CM, Gyawali B, Cosgrove A, Toh S, Xu Z, Guan X, Ross-Degnan D, Wagner AK. Real-world Use of and Spending on New Oral Targeted Cancer Drugs in the US, 2011-2018. JAMA Intern Med. 2021 12 01; 181(12):1596-1604. PMID: 34661604.
    Citations: 1     Fields:    Translation:Humans
  10. Cocoros NM, Haug N, Cosgrove A, Panozzo CA, Sorbello A, Francis H, Garcia C, Orr R, Toh S, Dutcher SK, Measer GT. Who gets treated for influenza: A surveillance study from the US Food and Drug Administration's Sentinel System. Infect Control Hosp Epidemiol. 2021 Aug 05; 1-7. PMID: 34350819.
    Citations:    Fields:    
  11. Hsu MC, Wang CC, Huang LY, Lin CY, Lin FJ, Toh S. Effect of ICD-9-CM to ICD-10-CM coding system transition on identification of common conditions: An interrupted time series analysis. Pharmacoepidemiol Drug Saf. 2021 12; 30(12):1653-1674. PMID: 34258812.
    Citations: 1     Fields:    Translation:Humans
  12. Gibson TB, Nguyen MD, Burrell T, Yoon F, Wong J, Dharmarajan S, Ouellet-Hellstrom R, Hua W, Ma Y, Baro E, Bloemers S, Pack C, Kennedy A, Toh S, Ball R. Electronic phenotyping of health outcomes of interest using a linked claims-electronic health record database: Findings from a machine learning pilot project. J Am Med Inform Assoc. 2021 07 14; 28(7):1507-1517. PMID: 33712852.
    Citations: 1     Fields:    Translation:Humans
  13. Pocobelli G, Dublin S, Bobb JF, Albertson-Junkans L, Andrade S, Cheetham TC, Salgado G, Griffin MR, Raebel MA, Smith D, Li DK, Pawloski PA, Toh S, Taylor L, Hua W, Horn P, Trinidad JP, Boudreau DM. Prevalence of prescription opioid use during pregnancy in eight US health plans during 2001-2014. Pharmacoepidemiol Drug Saf. 2021 11; 30(11):1541-1550. PMID: 34169607.
    Citations:    Fields:    Translation:Humans
  14. Aris IM, Lin PD, Rifas-Shiman SL, Bailey LC, Boone-Heinonen J, Eneli IU, Solomonides AE, Janicke DM, Toh S, Forrest CB, Block JP. Association of Early Antibiotic Exposure With Childhood Body Mass Index Trajectory Milestones. JAMA Netw Open. 2021 07 01; 4(7):e2116581. PMID: 34251440.
    Citations:    Fields:    Translation:Humans
  15. Her Q, Kent T, Samizo Y, Slavkovic A, Vilk Y, Toh S. Automatable Distributed Regression Analysis of Vertically Partitioned Data Facilitated by PopMedNet: Feasibility and Enhancement Study. JMIR Med Inform. 2021 Apr 23; 9(4):e21459. PMID: 33890866.
    Citations:    
  16. Cocoros NM, Fuller CC, Adimadhyam S, Ball R, Brown JS, Dal Pan GJ, Kluberg SA, Lo Re V, Maro JC, Nguyen M, Orr R, Paraoan D, Perlin J, Poland RE, Driscoll MR, Sands K, Toh S, Yih WK, Platt R. A COVID-19-ready public health surveillance system: The Food and Drug Administration's Sentinel System. Pharmacoepidemiol Drug Saf. 2021 07; 30(7):827-837. PMID: 33797815.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  17. Shu D, Toh S. ppmHR: A Privacy-protecting Tool to Fit Inverse Probability Weighted Cox Models in Multisite Studies. Epidemiology. 2021 03 01; 32(2):e6-e7. PMID: 33165009.
    Citations:    Fields:    Translation:Humans
  18. Eworuke E, Haug N, Bradley M, Cosgrove A, Zhang T, Dee EC, Adimadhyam S, Petrone A, Lee H, Woodworth T, Toh S. Risk of Nonmelanoma Skin Cancer in Association With Use of Hydrochlorothiazide-Containing Products in the United States. JNCI Cancer Spectr. 2021 04; 5(2). PMID: 33733052.
    Citations: 1     Fields:    Translation:Humans
  19. Shu D, Han P, Wang R, Toh S. Estimating the marginal hazard ratio by simultaneously using a set of propensity score models: A multiply robust approach. Stat Med. 2021 02 28; 40(5):1224-1242. PMID: 33410157.
    Citations:    Fields:    Translation:Humans
  20. Wong J, Murray Horwitz M, Bertisch SM, Herzig SJ, Buysse DJ, Toh S. Trends in Dispensing of Zolpidem and Low-Dose Trazodone Among Commercially Insured Adults in the United States, 2011-2018. JAMA. 2020 12 01; 324(21):2211-2213. PMID: 33258882.
    Citations: 4     Fields:    Translation:Humans
  21. Dong YH, Chang CH, Wang JL, Wu LC, Lin JW, Toh S. Association of Infections and Use of Fluoroquinolones With the Risk of Aortic Aneurysm or Aortic Dissection. JAMA Intern Med. 2020 12 01; 180(12):1587-1595. PMID: 32897358.
    Citations: 9     Fields:    Translation:Humans
  22. Huang K, Lin FJ, Ou HT, Hsu CN, Huang LY, Wang CC, Toh S. Building an active medical product safety surveillance system in Taiwan: Adaptation of the U.S. Sentinel System common data model structure to the National Health Insurance Research Database in Taiwan. Pharmacoepidemiol Drug Saf. 2021 01; 30(1):97-101. PMID: 33146908.
    Citations: 4     Fields:    Translation:Humans
  23. Fuller CC, Hua W, Leonard CE, Mosholder A, Carnahan R, Dutcher S, King K, Petrone AB, Rosofsky R, Shockro LA, Young J, Min JY, Binswanger I, Boudreau D, Griffin MR, Adgent MA, Kuntz J, McMahill-Walraven C, Pawloski PA, Ball R, Toh S. Developing a Standardized and Reusable Method to Link Distributed Health Plan Databases to the National Death Index: Methods Development Study Protocol. JMIR Res Protoc. 2020 Nov 02; 9(11):e21811. PMID: 33136063.
    Citations:    
  24. Fireman B, Gruber S, Zhang Z, Wellman R, Nelson JC, Franklin J, Maro J, Murray CR, Toh S, Gagne J, Schneeweiss S, Amsden L, Wyss R. Consequences of Depletion of Susceptibles for Hazard Ratio Estimators Based on Propensity Scores. Epidemiology. 2020 11; 31(6):806-814. PMID: 32841986.
    Citations: 1     Fields:    Translation:Humans
  25. Rifas-Shiman SL, Bailey LC, Lunsford D, Daley MF, Eneli I, Finkelstein J, Heerman W, Horgan CE, Hsia DS, Jay M, Rao G, Reynolds JS, Sturtevant JL, Toh S, Trasande L, Young J, Lin PD, Forrest CB, Block JP. Early Life Antibiotic Prescriptions and Weight Outcomes in Children 10 Years of Age. Acad Pediatr. 2021 03; 21(2):297-303. PMID: 33130067.
    Citations: 2     Fields:    Translation:Humans
  26. Adimadhyam S, Barreto EF, Cocoros NM, Toh S, Brown JS, Maro JC, Corrigan-Curay J, Dal Pan GJ, Ball R, Martin D, Nguyen M, Platt R, Li X. Leveraging the Capabilities of the FDA's Sentinel System To Improve Kidney Care. J Am Soc Nephrol. 2020 11; 31(11):2506-2516. PMID: 33077615.
    Citations: 2     Fields:    Translation:Humans
  27. Cocoros NM, Arlett P, Dreyer NA, Ishiguro C, Iyasu S, Sturkenboom M, Zhou W, Toh S. The Certainty Framework for Assessing Real-World Data in Studies of Medical Product Safety and Effectiveness. Clin Pharmacol Ther. 2021 05; 109(5):1189-1196. PMID: 32911562.
    Citations: 1     Fields:    Translation:Humans
  28. Arterburn DE, Toh S, Williams N, Anau J, Courcoulas A, Tavakkoli A, Stilwell D, Tuzzio L, Lewis CC, Wilcox MN, McTigue KM. Translating stakeholder-driven comparative effectiveness research into practice: the PCORnet Bariatric Study. J Comp Eff Res. 2020 10; 9(15):1035-1041. PMID: 33000638.
    Citations:    Fields:    
  29. Cheetham TC, Dublin S, Pocobelli G, Bobb JF, Andrade S, Hechter RC, Portugal C, Munis M, Albertson-Junkans L, Salgado G, Wong L, Maarup TJ, Carroll K, Griffin MR, Raebel MA, Smith D, Li DK, Pawloski PA, Toh S, Taylor L, Hua W, Dinatale M, Ceresa C, Trinidad JP, Boudreau DM. Validity of diagnosis and procedure codes for identifying neural tube defects in infants. Pharmacoepidemiol Drug Saf. 2020 11; 29(11):1489-1493. PMID: 32929845.
    Citations:    Fields:    Translation:Humans
  30. Li X, Lewis KH, Callaway K, Wharam JF, Toh S. Suitability of administrative claims databases for bariatric surgery research - is the glass half-full or half-empty? BMC Med Res Methodol. 2020 09 07; 20(1):225. PMID: 32894060.
    Citations: 1     Fields:    Translation:Humans
  31. Sansing-Foster V, Haug N, Mosholder A, Cocoros NM, Bradley M, Ma Y, Pennap D, Dee EC, Toh S, Pestine E, Petrone AB, Kim I, Lyons JG, Eworuke E. Risk of Psychiatric Adverse Events Among Montelukast Users. J Allergy Clin Immunol Pract. 2021 01; 9(1):385-393.e12. PMID: 32795564.
    Citations:    Fields:    Translation:Humans
  32. Shu D, Young JG, Toh S, Wang R. Variance estimation in inverse probability weighted Cox models. Biometrics. 2021 09; 77(3):1101-1117. PMID: 32662087.
    Citations: 1     Fields:    
  33. Her Q, Malenfant J, Zhang Z, Vilk Y, Young J, Tabano D, Hamilton J, Johnson R, Raebel M, Boudreau D, Toh S. Distributed Regression Analysis Application in Large Distributed Data Networks: Analysis of Precision and Operational Performance. JMIR Med Inform. 2020 Jun 04; 8(6):e15073. PMID: 32496200.
    Citations: 2     
  34. Maro JC, Eworuke E, Hou L, Welch EC, Goulding MR, Izem R, Lee JY, Toh S, Fireman B, Nguyen MD. Conducting prospective sequential surveillance in real-world dynamic distributed databases. Pharmacoepidemiol Drug Saf. 2020 10; 29(10):1331-1335. PMID: 32449261.
    Citations:    Fields:    Translation:Humans
  35. Marcus JL, Snowden JM, Murray Horwitz ME, Toh S, Horgan C, Tilney RC, Rajbhandari R, Back S, Westreich DJ. Use of Intrauterine Devices and Risk of Human Immunodeficiency Virus Acquisition Among Insured Women in the United States. Clin Infect Dis. 2020 05 06; 70(10):2221-2223. PMID: 31412356.
    Citations:    Fields:    Translation:HumansCells
  36. McTigue KM, Wellman R, Nauman E, Anau J, Coley RY, Odor A, Tice J, Coleman KJ, Courcoulas A, Pardee RE, Toh S, Janning CD, Williams N, Cook A, Sturtevant JL, Horgan C, Arterburn D. Comparing the 5-Year Diabetes Outcomes of Sleeve Gastrectomy and Gastric Bypass: The National Patient-Centered Clinical Research Network (PCORNet) Bariatric Study. JAMA Surg. 2020 05 01; 155(5):e200087. PMID: 32129809.
    Citations: 26     Fields:    Translation:Humans
  37. Coyle DT, Woodworth TS, Moeny D, Staffa J, Meyer T, Woods C, Welch EC, Haynes K, Toh S, Maro JC. Concomitant Filled Prescriptions of Oxymorphone or Oxycodone with CYP3A Inhibitors and Inducers. J Manag Care Spec Pharm. 2020 May; 26(5):668-672. PMID: 32347183.
    Citations:    Fields:    Translation:Humans
  38. Courcoulas A, Coley RY, Clark JM, McBride CL, Cirelli E, McTigue K, Arterburn D, Coleman KJ, Wellman R, Anau J, Toh S, Janning CD, Cook AJ, Williams N, Sturtevant JL, Horgan C, Tavakkoli A. Interventions and Operations 5 Years After Bariatric Surgery in a Cohort From the US National Patient-Centered Clinical Research Network Bariatric Study. JAMA Surg. 2020 03 01; 155(3):194-204. PMID: 31940024.
    Citations: 12     Fields:    Translation:Humans
  39. Webster-Clark M, Huang TY, Hou L, Toh S. Translating claims-based CHA2 DS2 -VaSc and HAS-BLED to ICD-10-CM: Impacts of mapping strategies. Pharmacoepidemiol Drug Saf. 2020 04; 29(4):409-418. PMID: 32067286.
    Citations: 1     Fields:    Translation:Humans
  40. Wu J, Wang C, Toh S, Pisa FE, Bauer L. Use of real-world evidence in regulatory decisions for rare diseases in the United States-Current status and future directions. Pharmacoepidemiol Drug Saf. 2020 10; 29(10):1213-1218. PMID: 32003065.
    Citations: 8     Fields:    Translation:Humans
  41. Toh S. Analytic and Data Sharing Options in Real-World Multidatabase Studies of Comparative Effectiveness and Safety of Medical Products. Clin Pharmacol Ther. 2020 04; 107(4):834-842. PMID: 31869442.
    Citations: 3     Fields:    Translation:Humans
  42. Wyss R, Gagne JJ, Zhao Y, Zhou EH, Major JM, Wang SV, Desai RJ, Franklin JM, Schneeweiss S, Toh S, Johnson M, Fireman B. Use of Time-Dependent Propensity Scores to Adjust Hazard Ratio Estimates in Cohort Studies with Differential Depletion of Susceptibles. Epidemiology. 2020 01; 31(1):82-89. PMID: 31569120.
    Citations: 1     Fields:    Translation:Humans
  43. Huang TY, Welch EC, Shinde MU, Platt RW, Filion KB, Azoulay L, Maro JC, Platt R, Toh S. Reproducing Protocol-Based Studies Using Parameterizable Tools-Comparison of Analytic Approaches Used by Two Medical Product Surveillance Networks. Clin Pharmacol Ther. 2020 04; 107(4):966-977. PMID: 31630391.
    Citations: 1     Fields:    Translation:Humans
  44. Dutcher SK, Fazio-Eynullayeva E, Eworuke E, Carruth A, Dee EC, Blum MD, Nguyen MD, Toh S, Panozzo CA, Lyons JG. Understanding utilization patterns of biologics and biosimilars in the United States to support postmarketing studies of safety and effectiveness. Pharmacoepidemiol Drug Saf. 2020 07; 29(7):786-795. PMID: 31828887.
    Citations: 2     Fields:    Translation:Humans
  45. Shu D, Young JG, Toh S. Privacy-protecting estimation of adjusted risk ratios using modified Poisson regression in multi-center studies. BMC Med Res Methodol. 2019 12 05; 19(1):228. PMID: 31805872.
    Citations: 1     Fields:    Translation:Humans
  46. Mott K, Reichman ME, Toh S, Kieswetter C, Haffenreffer K, Andrade SE. Use of Antidiabetic drugs during pregnancy among U.S. women with Livebirth deliveries in the Mini-Sentinel system. BMC Pregnancy Childbirth. 2019 Nov 27; 19(1):441. PMID: 31775682.
    Citations: 2     Fields:    Translation:Humans
  47. Toh S, Rifas-Shiman SL, Lin PD, Bailey LC, Forrest CB, Horgan CE, Lunsford D, Moyneur E, Sturtevant JL, Young JG, Block JP. Privacy-protecting multivariable-adjusted distributed regression analysis for multi-center pediatric study. Pediatr Res. 2020 05; 87(6):1086-1092. PMID: 31578038.
    Citations: 2     Fields:    Translation:Humans
  48. Wood ME, Andrade SE, Toh S. Safe Expectations: Current State and Future Directions for Medication Safety in Pregnancy Research. Clin Ther. 2019 12; 41(12):2467-2476. PMID: 31563392.
    Citations: 2     Fields:    Translation:Humans
  49. Cocoros NM, Haynes K, Her Q, Cosgrove A, Dee E, Lin ND, Tu CM, Ding Y, Nguyen M, Toh S. Identification of potential drug name confusion errors in the Sentinel System. Pharmacoepidemiol Drug Saf. 2019 10; 28(10):1405-1410. PMID: 31483085.
    Citations:    Fields:    Translation:Humans
  50. Shu D, Yoshida K, Fireman BH, Toh S. Inverse probability weighted Cox model in multi-site studies without sharing individual-level data. Stat Methods Med Res. 2020 06; 29(6):1668-1681. PMID: 31448681.
    Citations: 1     Fields:    
  51. Bohn J, Schneeweiss S, Glynn RJ, Toh S, Wyss R, Desai R, Gagne JJ. Controlling Confounding in a Study of Oral Anticoagulants: Comparing Disease Risk Scores Developed Using Different Follow-Up Approaches. EGEMS (Wash DC). 2019 Jul 15; 7(1):27. PMID: 31346542.
    Citations: 1     
  52. Taylor LG, Panucci G, Mosholder AD, Toh S, Huang TY. Antipsychotic Use and Stroke: A Retrospective Comparative Study in a Non-Elderly Population. J Clin Psychiatry. 2019 06 04; 80(4). PMID: 31163104.
    Citations: 3     Fields:    Translation:Humans
  53. Desai RJ, Wyss R, Abdia Y, Toh S, Johnson M, Lee H, Karami S, Major JM, Nguyen M, Wang SV, Franklin JM, Gagne JJ. Evaluating the use of bootstrapping in cohort studies conducted with 1:1 propensity score matching-A plasmode simulation study. Pharmacoepidemiol Drug Saf. 2019 06; 28(6):879-886. PMID: 31020732.
    Citations:    Fields:    Translation:Humans
  54. Her QL, Toh S. Sound-Alike Look-Alike Confusion and Matching Medication Product Attributes: Simulated Case-Control Studies. Ann Pharmacother. 2019 10; 53(10):973-980. PMID: 30999762.
    Citations:    Fields:    Translation:Humans
  55. Lin PD, Daley MF, Boone-Heinonen J, Rifas-Shiman SL, Bailey LC, Forrest CB, Horgan CE, Sturtevant JL, Toh S, Young JG, Block JP. Comparing Prescribing and Dispensing Data of the PCORnet Common Data Model Within PCORnet Antibiotics and Childhood Growth Study. EGEMS (Wash DC). 2019 Apr 12; 7(1):11. PMID: 30993145.
    Citations: 5     
  56. Li X, Fireman BH, Curtis JR, Arterburn DE, Fisher DP, Moyneur É, Gallagher M, Raebel MA, Nowell WB, Lagreid L, Toh S. Validity of Privacy-Protecting Analytical Methods That Use Only Aggregate-Level Information to Conduct Multivariable-Adjusted Analysis in Distributed Data Networks. Am J Epidemiol. 2019 04 01; 188(4):709-723. PMID: 30535131.
    Citations: 5     Fields:    Translation:Humans
  57. Singh S, Fouayzi H, Anzuoni K, Goldman L, Min JY, Griffin M, Grijalva CG, Morrow JA, Whitmore CC, Leonard CE, Selvan M, Nair V, Zhou Y, Toh S, Petrone A, Williams J, Fazio-Eynullayeva E, Swain R, Tyler Coyle D, Andrade S. Diagnostic Algorithms for Cardiovascular Death in Administrative Claims Databases: A Systematic Review. Drug Saf. 2019 04; 42(4):515-527. PMID: 30471046.
    Citations: 6     Fields:    Translation:Humans
  58. Petrone AB, DuCott A, Gagne JJ, Toh S, Maro JC. The Devil's in the details: Reports on reproducibility in pharmacoepidemiologic studies. Pharmacoepidemiol Drug Saf. 2019 05; 28(5):671-679. PMID: 30843303.
    Citations: 2     Fields:    
  59. Carnahan RM, Gagne JJ, Hampp C, Leonard CE, Toh S, Fuller CC, Hennessy S, Hou L, Cocoros NM, Panucci G, Woodworth T, Cosgrove A, Iyer A, Chrischilles EA. Evaluation of the US Food and Drug Administration Sentinel Analysis Tools Using a Comparator with a Different Indication: Comparing the Rates of Gastrointestinal Bleeding in Warfarin and Statin Users. Pharmaceut Med. 2019 02; 33(1):29-43. PMID: 31933271.
    Citations: 2     Translation:Humans
  60. Bird ST, Toh S, Sahin L, Andrade SE, Gelperin K, Taylor L, Song J, Hampp C. Misclassification in Assessment of First Trimester In-utero Exposure to Drugs Used Proximally to Conception: the Example of Letrozole Utilization for Infertility Treatment. Am J Epidemiol. 2019 02 01; 188(2):418-425. PMID: 30321259.
    Citations: 2     Fields:    Translation:Humans
  61. Heerman WJ, Daley MF, Boone-Heinonen J, Rifas-Shiman SL, Bailey LC, Forrest CB, Young JG, Gillman MW, Horgan CE, Janicke DM, Jenter C, Kharbanda EO, Lunsford D, Messito MJ, Toh S, Block JP. Maternal antibiotic use during pregnancy and childhood obesity at age 5 years. Int J Obes (Lond). 2019 06; 43(6):1202-1209. PMID: 30670848.
    Citations: 12     Fields:    Translation:Humans
  62. Toh S, Wellman R, Coley RY, Horgan C, Sturtevant J, Moyneur E, Janning C, Pardee R, Coleman KJ, Arterburn D, McTigue K, Anau J, Cook AJ. Combining distributed regression and propensity scores: a doubly privacy-protecting analytic method for multicenter research. Clin Epidemiol. 2018; 10:1773-1786. PMID: 30568510.
    Citations: 3     
  63. Eworuke E, Panucci G, Goulding M, Neuner R, Toh S. Use of tumor necrosis factor-alpha inhibitors during pregnancy among women who delivered live born infants. Pharmacoepidemiol Drug Saf. 2019 03; 28(3):296-304. PMID: 30430682.
    Citations: 2     Fields:    Translation:Humans
  64. Swain RS, Taylor LG, Woodworth TS, Fuller CC, Petrone AB, Menzin TJ, Haug NR, Toh S, Mosholder AD. Overall and cause-specific mortality in the Sentinel system: A power analysis. Pharmacoepidemiol Drug Saf. 2018 Dec; 27(12):1416-1421. PMID: 30421839.
    Citations:    Fields:    Translation:Humans
  65. Li J, Panucci G, Moeny D, Liu W, Maro JC, Toh S, Huang TY. Association of Risk for Venous Thromboembolism With Use of Low-Dose Extended- and Continuous-Cycle Combined Oral Contraceptives: A Safety Study Using the Sentinel Distributed Database. JAMA Intern Med. 2018 11 01; 178(11):1482-1488. PMID: 30285041.
    Citations: 2     Fields:    Translation:Humans
  66. Desai RJ, Wyss R, Jin Y, Bohn J, Toh S, Cosgrove A, Kennedy A, Kim J, Kim C, Ouellet-Hellstrom R, Karami S, Major JM, Niman A, Wang SV, Gagne JJ. Extension of Disease Risk Score-Based Confounding Adjustments for Multiple Outcomes of Interest: An Empirical Evaluation. Am J Epidemiol. 2018 11 01; 187(11):2439-2448. PMID: 29947726.
    Citations: 5     Fields:    Translation:Humans
  67. Block JP, Bailey LC, Gillman MW, Lunsford D, Daley MF, Eneli I, Finkelstein J, Heerman W, Horgan CE, Hsia DS, Jay M, Rao G, Reynolds JS, Rifas-Shiman SL, Sturtevant JL, Toh S, Trasande L, Young J, Forrest CB. Early Antibiotic Exposure and Weight Outcomes in Young Children. Pediatrics. 2018 12; 142(6). PMID: 30381474.
    Citations: 18     Fields:    Translation:Humans
  68. Arterburn D, Wellman R, Emiliano A, Smith SR, Odegaard AO, Murali S, Williams N, Coleman KJ, Courcoulas A, Coley RY, Anau J, Pardee R, Toh S, Janning C, Cook A, Sturtevant J, Horgan C, McTigue KM. Comparative Effectiveness and Safety of Bariatric Procedures for Weight Loss: A PCORnet Cohort Study. Ann Intern Med. 2018 12 04; 169(11):741-750. PMID: 30383139.
    Citations: 38     Fields:    Translation:Humans
  69. Cottreau CM, Dashevsky I, Andrade SE, Li DK, Nekhlyudov L, Raebel MA, Ritzwoller DP, Partridge AH, Pawloski PA, Toh S. Pregnancy-Associated Cancer: A U.S. Population-Based Study. J Womens Health (Larchmt). 2019 02; 28(2):250-257. PMID: 30307780.
    Citations: 14     Fields:    Translation:Humans
  70. Mosholder AD, Taylor L, Mannheim G, Ortendahl L, Woodworth TS, Toh S. Incidence of Heart Failure and Cardiomyopathy Following Initiation of Medications for Attention-Deficit/Hyperactivity Disorder: A Descriptive Study. J Clin Psychopharmacol. 2018 Oct; 38(5):505-508. PMID: 30102629.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  71. Wong J, Horwitz MM, Zhou L, Toh S. Using machine learning to identify health outcomes from electronic health record data. Curr Epidemiol Rep. 2018 Dec; 5(4):331-342. PMID: 30555773.
    Citations: 8     
  72. Sun JW, Rogers JR, Her Q, Welch EC, Panozzo CA, Toh S, Gagne JJ. Validation of the Combined Comorbidity Index of Charlson and Elixhauser to Predict 30-Day Mortality Across ICD-9 and ICD-10. Med Care. 2018 09; 56(9):812. PMID: 30001251.
    Citations: 5     Fields:    
  73. Ball R, Toh S, Nolan J, Haynes K, Forshee R, Botsis T. Evaluating automated approaches to anaphylaxis case classification using unstructured data from the FDA Sentinel System. Pharmacoepidemiol Drug Saf. 2018 10; 27(10):1077-1084. PMID: 30152575.
    Citations: 6     Fields:    Translation:HumansPHPublic Health
  74. Cocoros NM, Panucci G, Haug N, Maher C, Reichman M, Toh S. Outpatient influenza antivirals in a distributed data network for influenza surveillance. Influenza Other Respir Viruses. 2018 11; 12(6):804-807. PMID: 30053342.
    Citations: 4     Fields:    Translation:Humans
  75. Yoshida K, Gruber S, Fireman BH, Toh S. Comparison of privacy-protecting analytic and data-sharing methods: A simulation study. Pharmacoepidemiol Drug Saf. 2018 09; 27(9):1034-1041. PMID: 30022561.
    Citations: 6     Fields:    Translation:Humans
  76. Panozzo CA, Welch EC, Woodworth TS, Huang TY, Her QL, Gagne JJ, Sun JW, Rogers C, Menzin TJ, Ehrmann M, Freitas KE, Haug NR, Toh S. Assessing the impact of the new ICD-10-CM coding system on pharmacoepidemiologic studies-An application to the known association between angiotensin-converting enzyme inhibitors and angioedema. Pharmacoepidemiol Drug Saf. 2018 08; 27(8):829-838. PMID: 29947045.
    Citations: 4     Fields:    Translation:Humans
  77. Panozzo CA, Woodworth TS, Welch EC, Huang TY, Her QL, Haynes K, Rogers C, Menzin TJ, Ehrmann M, Freitas KE, Haug NR, Toh S. Early impact of the ICD-10-CM transition on selected health outcomes in 13 electronic health care databases in the United States. Pharmacoepidemiol Drug Saf. 2018 08; 27(8):839-847. PMID: 29947033.
    Citations: 20     Fields:    Translation:Humans
  78. Her QL, Malenfant JM, Malek S, Vilk Y, Young J, Li L, Brown J, Toh S. A Query Workflow Design to Perform Automatable Distributed Regression Analysis in Large Distributed Data Networks. EGEMS (Wash DC). 2018 May 25; 6(1):11. PMID: 30094283.
    Citations: 9     
  79. Lu CY, Penfold RB, Toh S, Sturtevant JL, Madden JM, Simon G, Ahmedani BK, Clarke G, Coleman KJ, Copeland LA, Daida YG, Davis RL, Hunkeler EM, Owen-Smith A, Raebel MA, Rossom R, Soumerai SB, Kulldorff M. Near Real-time Surveillance for Consequences of Health Policies Using Sequential Analysis. Med Care. 2018 05; 56(5):365-372. PMID: 29634627.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  80. Inge TH, Coley RY, Bazzano LA, Xanthakos SA, McTigue K, Arterburn D, Williams N, Wellman R, Coleman KJ, Courcoulas A, Desai NK, Anau J, Pardee R, Toh S, Janning C, Cook A, Sturtevant J, Horgan C, Zebrick AJ, Michalsky M. Comparative effectiveness of bariatric procedures among adolescents: the PCORnet bariatric study. Surg Obes Relat Dis. 2018 Sep; 14(9):1374-1386. PMID: 29793877.
    Citations: 19     Fields:    Translation:Humans
  81. Li X, Lund JL, Toh S. Lower Cancer Incidence-Warfarin Effect or Immortal Time Bias? JAMA Intern Med. 2018 04 01; 178(4):584-585. PMID: 29610881.
    Citations:    Fields:    Translation:Humans
  82. Dong YH, Chang CH, Wu LC, Hwang JS, Toh S. Comparative cardiovascular safety of nonsteroidal anti-inflammatory drugs in patients with hypertension: a population-based cohort study. Br J Clin Pharmacol. 2018 05; 84(5):1045-1056. PMID: 29468706.
    Citations: 3     Fields:    Translation:Humans
  83. Carnahan RM, Kuntz JL, Wang SV, Fuller C, Gagne JJ, Leonard CE, Hennessy S, Meyer T, Archdeacon P, Chen CY, Panozzo CA, Toh S, Katcoff H, Woodworth T, Iyer A, Axtman S, Chrischilles EA. Evaluation of the US Food and Drug Administration sentinel analysis tools in confirming previously observed drug-outcome associations: The case of clindamycin and Clostridium difficile infection. Pharmacoepidemiol Drug Saf. 2018 07; 27(7):731-739. PMID: 29532543.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  84. Illoh OA, Toh S, Andrade SE, Hampp C, Sahin L, Gelperin K, Taylor L, Bird ST. Utilization of drugs with pregnancy exposure registries during pregnancy. Pharmacoepidemiol Drug Saf. 2018 06; 27(6):604-611. PMID: 29516585.
    Citations: 2     Fields:    Translation:Humans
  85. Martin D, Gagne JJ, Gruber S, Izem R, Nelson JC, Nguyen MD, Ouellet-Hellstrom R, Schneeweiss S, Toh S, Walker AM. Sequential surveillance for drug safety in a regulatory environment. Pharmacoepidemiol Drug Saf. 2018 07; 27(7):707-712. PMID: 29504168.
    Citations: 4     Fields:    Translation:Humans
  86. Andrade SE, Bérard A, Nordeng HME, Wood ME, van Gelder MMHJ, Toh S. Correction to: Administrative Claims Data Versus Augmented Pregnancy Data for the Study of Pharmaceutical Treatments in Pregnancy. Curr Epidemiol Rep. 2018; 5(1):60. PMID: 31329795.
    Citations:    
  87. Chrischilles EA, Gagne JJ, Fireman B, Nelson J, Toh S, Shoaibi A, Reichman ME, Wang S, Nguyen M, Zhang R, Izem R, Goulding MR, Southworth MR, Graham DJ, Fuller C, Katcoff H, Woodworth T, Rogers C, Saliga R, Lin ND, McMahill-Walraven CN, Nair VP, Haynes K, Carnahan RM. Prospective surveillance pilot of rivaroxaban safety within the US Food and Drug Administration Sentinel System. Pharmacoepidemiol Drug Saf. 2018 03; 27(3):263-271. PMID: 29318683.
    Citations: 2     Fields:    Translation:Humans
  88. Bird ST, Gelperin K, Taylor L, Sahin L, Hammad H, Andrade SE, Mohamoud MA, Toh S, Hampp C. Enrollment and Retention in 34 United States Pregnancy Registries Contrasted with the Manufacturer's Capture of Spontaneous Reports for Exposed Pregnancies. Drug Saf. 2018 01; 41(1):87-94. PMID: 28840499.
    Citations: 6     Fields:    Translation:Humans
  89. Toh S, Rasmussen-Torvik LJ, Harmata EE, Pardee R, Saizan R, Malanga E, Sturtevant JL, Horgan CE, Anau J, Janning CD, Wellman RD, Coley RY, Cook AJ, Courcoulas AP, Coleman KJ, Williams NA, McTigue KM, Arterburn D, McClay J. The National Patient-Centered Clinical Research Network (PCORnet) Bariatric Study Cohort: Rationale, Methods, and Baseline Characteristics. JMIR Res Protoc. 2017 Dec 05; 6(12):e222. PMID: 29208590.
    Citations: 11     
  90. Sun JW, Rogers JR, Her Q, Welch EC, Panozzo CA, Toh S, Gagne JJ. Adaptation and Validation of the Combined Comorbidity Score for ICD-10-CM. Med Care. 2017 12; 55(12):1046-1051. PMID: 29087983.
    Citations: 11     Fields:    Translation:Humans
  91. Go AS, Singer DE, Toh S, Cheetham TC, Reichman ME, Graham DJ, Southworth MR, Zhang R, Izem R, Goulding MR, Houstoun M, Mott K, Sung SH, Gagne JJ. Outcomes of Dabigatran and Warfarin for Atrial Fibrillation in Contemporary Practice: A Retrospective Cohort Study. Ann Intern Med. 2017 Dec 19; 167(12):845-854. PMID: 29132153.
    Citations: 12     Fields:    Translation:Humans
  92. Toh S, Reichman ME, Graham DJ, Hampp C, Zhang R, Butler MG, Iyer A, Rucker M, Pimentel M, Hamilton J, Lendle S, Fireman BH. Prospective Postmarketing Surveillance of Acute Myocardial Infarction in New Users of Saxagliptin: A Population-Based Study. Diabetes Care. 2018 01; 41(1):39-48. PMID: 29122893.
    Citations: 4     Fields:    Translation:Humans
  93. Gagne JJ, Houstoun M, Reichman ME, Hampp C, Marshall JH, Toh S. Safety assessment of niacin in the US Food and Drug Administration's mini-sentinel system. Pharmacoepidemiol Drug Saf. 2018 01; 27(1):30-37. PMID: 29108128.
    Citations:    Fields:    Translation:Humans
  94. Zhou M, Wang SV, Leonard CE, Gagne JJ, Fuller C, Hampp C, Archdeacon P, Toh S, Iyer A, Woodworth TS, Cavagnaro E, Panozzo CA, Axtman S, Carnahan RM, Chrischilles EA, Hennessy S. Sentinel Modular Program for Propensity Score-Matched Cohort Analyses: Application to Glyburide, Glipizide, and Serious Hypoglycemia. Epidemiology. 2017 11; 28(6):838-846. PMID: 28682851.
    Citations: 14     Fields:    Translation:HumansPHPublic Health
  95. Toh S. Pharmacoepidemiology in the era of real-world evidence. Curr Epidemiol Rep. 2017 Dec; 4(4):262-265. PMID: 29204331.
    Citations: 1     
  96. Li X, Young JG, Toh S. Estimating Effects of Dynamic Treatment Strategies in Pharmacoepidemiologic Studies with Time-varying Confounding: A Primer. Curr Epidemiol Rep. 2017 Dec; 4(4):288-297. PMID: 29204332.
    Citations: 3     
  97. Baker MA, Butler MG, Seymour S, Zhang F, Wu Y, Wu AC, Levenson MS, Wu P, Iyer A, Toh S, Iyasu S, Zhou EH. The impact of FDA regulatory activities on incident dispensing of LABA-containing medication: 2005-2011. J Asthma. 2018 08; 55(8):907-914. PMID: 28910559.
    Citations:    Fields:    Translation:Humans
  98. Connolly JG, Wang SV, Fuller CC, Toh S, Panozzo CA, Cocoros N, Zhou M, Gagne JJ, Maro JC. Development and application of two semi-automated tools for targeted medical product surveillance in a distributed data network. Curr Epidemiol Rep. 2017 Dec; 4(4):298-306. PMID: 29204333.
    Citations: 4     
  99. Wang SV, Schneeweiss S, Berger ML, Brown J, de Vries F, Douglas I, Gagne JJ, Gini R, Klungel O, Mullins CD, Nguyen MD, Rassen JA, Smeeth L, Sturkenboom M. Reporting to Improve Reproducibility and Facilitate Validity Assessment for Healthcare Database Studies V1.0. Pharmacoepidemiol Drug Saf. 2017 09; 26(9):1018-1032. PMID: 28913963.
    Citations: 40     Fields:    Translation:Humans
  100. Mazor KM, Richards A, Gallagher M, Arterburn DE, Raebel MA, Nowell WB, Curtis JR, Paolino AR, Toh S. Stakeholders' views on data sharing in multicenter studies. J Comp Eff Res. 2017 Sep; 6(6):537-547. PMID: 28805448.
    Citations: 13     Fields:    Translation:Humans
  101. Lu CY, Williams MS, Ginsburg GS, Toh S, Brown JS, Khoury MJ. A proposed approach to accelerate evidence generation for genomic-based technologies in the context of a learning health system. Genet Med. 2018 Apr; 20(4):390-396. PMID: 28796238.
    Citations: 9     Fields:    Translation:Humans
  102. Goto T, Faridi MK, Gibo K, Toh S, Hanania NA, Camargo CA, Hasegawa K. Trends in 30-day readmission rates after COPD hospitalization, 2006-2012. Respir Med. 2017 Sep; 130:92-97. PMID: 29206640.
    Citations: 19     Fields:    Translation:Humans
  103. Andrade SE, Bérard A, Nordeng HME, Wood ME, van Gelder MMHJ, Toh S. Administrative Claims Data Versus Augmented Pregnancy Data for the Study of Pharmaceutical Treatments in Pregnancy. Curr Epidemiol Rep. 2017; 4(2):106-116. PMID: 29399433.
    Citations: 10     
  104. Taylor LG, Bird ST, Sahin L, Tassinari MS, Greene P, Reichman ME, Andrade SE, Haffenreffer K, Toh S. Antiemetic use among pregnant women in the United States: the escalating use of ondansetron. Pharmacoepidemiol Drug Saf. 2017 May; 26(5):592-596. PMID: 28220993.
    Citations: 8     Fields:    Translation:Humans
  105. Tan EC, Bell JS, Lu CY, Toh S. National Trends in Outpatient Antihypertensive Prescribing in People with Dementia in the United States. J Alzheimers Dis. 2016 10 18; 54(4):1425-1435. PMID: 27589531.
    Citations: 2     Fields:    Translation:Humans
  106. Gagne JJ, Han X, Hennessy S, Leonard CE, Chrischilles EA, Carnahan RM, Wang SV, Fuller C, Iyer A, Katcoff H, Woodworth TS, Archdeacon P, Meyer TE, Schneeweiss S, Toh S. Successful Comparison of US Food and Drug Administration Sentinel Analysis Tools to Traditional Approaches in Quantifying a Known Drug-Adverse Event Association. Clin Pharmacol Ther. 2016 Nov; 100(5):558-564. PMID: 27416001.
    Citations: 14     Fields:    Translation:Humans
  107. Gruber S, Chakravarty A, Heckbert SR, Levenson M, Martin D, Nelson JC, Psaty BM, Pinheiro S, Reich CG, Toh S, Walker AM. Design and analysis choices for safety surveillance evaluations need to be tuned to the specifics of the hypothesized drug-outcome association. Pharmacoepidemiol Drug Saf. 2016 09; 25(9):973-81. PMID: 27418432.
    Citations: 6     Fields:    Translation:Humans
  108. Andrade SE, Reichman ME, Mott K, Pitts M, Kieswetter C, Dinatale M, Stone MB, Popovic J, Haffenreffer K, Toh S. Use of selective serotonin reuptake inhibitors (SSRIs) in women delivering liveborn infants and other women of child-bearing age within the U.S. Food and Drug Administration's Mini-Sentinel program. Arch Womens Ment Health. 2016 12; 19(6):969-977. PMID: 27178125.
    Citations: 13     Fields:    Translation:HumansPHPublic Health
  109. Mott K, Graham DJ, Toh S, Gagne JJ, Levenson M, Ma Y, Reichman ME. Uptake of new drugs in the early post-approval period in the Mini-Sentinel distributed database. Pharmacoepidemiol Drug Saf. 2016 09; 25(9):1023-32. PMID: 27146123.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  110. Toh S, Hampp C, Reichman ME, Graham DJ, Balakrishnan S, Pucino F, Hamilton J, Lendle S, Iyer A, Rucker M, Pimentel M, Nathwani N, Griffin MR, Brown NJ, Fireman BH. Risk for Hospitalized Heart Failure Among New Users of Saxagliptin, Sitagliptin, and Other Antihyperglycemic Drugs: A Retrospective Cohort Study. Ann Intern Med. 2016 Jun 07; 164(11):705-14. PMID: 27110660.
    Citations: 30     Fields:    Translation:Humans
  111. Andrade SE, Toh S, Houstoun M, Mott K, Pitts M, Kieswetter C, Ceresa C, Haffenreffer K, Reichman ME. Surveillance of Medication Use During Pregnancy in the Mini-Sentinel Program. Matern Child Health J. 2016 Apr; 20(4):895-903. PMID: 26645616.
    Citations: 14     Fields:    Translation:Humans
  112. Butler MG, Zhou EH, Zhang F, Wu YT, Wu AC, Levenson MS, Wu P, Seymour S, Toh S, Iyer A, Iyasu S, Baker MA. Changing patterns of asthma medication use related to US Food and Drug Administration long-acting ß2-agonist regulation from 2005-2011. J Allergy Clin Immunol. 2016 Mar; 137(3):710-7. PMID: 26725997.
    Citations: 5     Fields:    Translation:Humans
  113. Hansen C, Andrade SE, Freiman H, Dublin S, Haffenreffer K, Cooper WO, Cheetham TC, Toh S, Li DK, Raebel MA, Kuntz JL, Perrin N, Rosales AG, Carter S, Pawloski PA, Maloney EM, Graham DJ, Sahin L, Scott PE, Yap J, Davis R. Trimethoprim-sulfonamide use during the first trimester of pregnancy and the risk of congenital anomalies. Pharmacoepidemiol Drug Saf. 2016 Feb; 25(2):170-8. PMID: 26599424.
    Citations: 7     Fields:    Translation:Humans
  114. Cameron C, Fireman B, Hutton B, Clifford T, Coyle D, Wells G, Dormuth CR, Platt R, Toh S. Network meta-analysis incorporating randomized controlled trials and non-randomized comparative cohort studies for assessing the safety and effectiveness of medical treatments: challenges and opportunities. Syst Rev. 2015 Nov 05; 4:147. PMID: 26537988.
    Citations: 34     Fields:    Translation:Humans
  115. Guidelines for good pharmacoepidemiology practice (GPP). Pharmacoepidemiol Drug Saf. 2016 Jan; 25(1):2-10. PMID: 26537534.
    Citations: 46     Fields:    Translation:Humans
  116. Arterburn D, Powers JD, Toh S, Polsky S, Butler MG, Portz JD, Donahoo WT, Herrinton L, Williams RJ, Vijayadeva V, Fisher D, Bayliss EA. Comparative effectiveness of laparoscopic adjustable gastric banding vs laparoscopic gastric bypass. JAMA Surg. 2014 Dec; 149(12):1279-87. PMID: 25353723.
    Citations: 11     Fields:    Translation:Humans
  117. Dublin S, Johnson KE, Walker RL, Avalos LA, Andrade SE, Beaton SJ, Davis RL, Herrinton LJ, Pawloski PA, Raebel MA, Smith DH, Toh S, Caughey AB. Trends in elective labor induction for six United States health plans, 2001-2007. J Womens Health (Larchmt). 2014 Nov; 23(11):904-11. PMID: 25330378.
    Citations: 8     Fields:    Translation:Humans
  118. Bell C, Chakravarty A, Gruber S, Heckbert SR, Levenson M, Martin D, Nelson JC, Pinheiro S, Psaty BM, Reich CG, Schneeweiss S, Shoaibi A, Toh S, Walker AM. Characteristics of study design and elements that may contribute to the success of electronic safety monitoring systems. Pharmacoepidemiol Drug Saf. 2014 Nov; 23(11):1223-5. PMID: 25263307.
    Citations: 1     Fields:    Translation:Humans
  119. Garabedian LF, Chu P, Toh S, Zaslavsky AM, Soumerai SB. Potential bias of instrumental variable analyses for observational comparative effectiveness research. Ann Intern Med. 2014 Jul 15; 161(2):131-8. PMID: 25023252.
    Citations: 46     Fields:    Translation:Humans
  120. Toh S, Shetterly S, Powers JD, Arterburn D. Privacy-preserving analytic methods for multisite comparative effectiveness and patient-centered outcomes research. Med Care. 2014 Jul; 52(7):664-8. PMID: 24926715.
    Citations: 14     Fields:    Translation:Humans
  121. Raebel MA, Newcomer SR, Bayliss EA, Boudreau D, DeBar L, Elliott TE, Ahmed AT, Pawloski PA, Fisher D, Toh S, Donahoo WT. Chronic opioid use emerging after bariatric surgery. Pharmacoepidemiol Drug Saf. 2014 Dec; 23(12):1247-57. PMID: 24733580.
    Citations: 26     Fields:    Translation:Humans
  122. Bussing R, Narwaney KJ, Winterstein AG, Newton DA, DeBar L, Boscarino JA, Toh S, Pawloski P, Nordin JD, Herrinton LJ, Mason D, Daley MF. Pharmacotherapy for incident attention-deficit/hyperactivity disorder: practice patterns and quality metrics. Curr Med Res Opin. 2014 Aug; 30(8):1687-99. PMID: 24635013.
    Citations: 4     Fields:    Translation:Humans
  123. Toh S, Avorn J, D'Agostino RB, Gurwitz JH, Psaty BM, Rothman KJ, Saag KG, Sturkenboom MC, Vandenbroucke JP, Winterstein AG, Strom BL. RE: Drug risk assessment and data reuse. Pharmacoepidemiol Drug Saf. 2014 Jan; 23(1):109-10. PMID: 24395550.
    Citations:    Fields:    Translation:Humans
  124. Briesacher BA, Soumerai SB, Zhang F, Toh S, Andrade SE, Wagner JL, Shoaibi A, Gurwitz JH. Response to the letter by Mol. Pharmacoepidemiol Drug Saf. 2014 Jan; 23(1):106. PMID: 24395548.
    Citations:    Fields:    Translation:PHPublic Health
  125. Avalos LA, Chen H, Yang C, Andrade SE, Cooper WO, Cheetham CT, Davis RL, Dublin S, Hammad TA, Kaplan S, Pawloski PA, Raebel MA, Scott PE, Smith DH, Toh S, Li DK. The prevalence and trends of antiviral medication use during pregnancy in the US: a population-based study of 664,297 deliveries in 2001-2007. Matern Child Health J. 2014 Jan; 18(1):64-72. PMID: 23420306.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  126. Daley MF, Newton DA, DeBar L, Newcomer SR, Pieper L, Boscarino JA, Toh S, Pawloski P, Nordin JD, Nakasato C, Herrinton LJ, Bussing R. Accuracy of Electronic Health Record-Derived Data for the Identification of Incident ADHD. J Atten Disord. 2017 03; 21(5):416-425. PMID: 24510475.
    Citations: 6     Fields:    Translation:Humans
  127. Toh S, Manson JE. An analytic framework for aligning observational and randomized trial data: Application to postmenopausal hormone therapy and coronary heart disease. Stat Biosci. 2013 Nov 01; 5(2). PMID: 24244222.
    Citations: 8     
  128. Toh S, Platt R. Big data in epidemiology: too big to fail? Epidemiology. 2013 Nov; 24(6):939. PMID: 24077001.
    Citations: 3     Fields:    Translation:Humans
  129. Hansen C, Joski P, Freiman H, Andrade S, Toh S, Dublin S, Cheetham C, Cooper W, Pawloski P, Li DK, Beaton S, Kaplan S, Scott P, Hammad T, Davis R. Medication exposure in pregnancy risk evaluation program: the prevalence of asthma medication use during pregnancy. Matern Child Health J. 2013 Nov; 17(9):1611-21. PMID: 23108737.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  130. Kim SC, Gillet VG, Feldman S, Lii H, Toh S, Brown JS, Katz JN, Solomon DH, Schneeweiss S. Validation of claims-based algorithms for identification of high-grade cervical dysplasia and cervical cancer. Pharmacoepidemiol Drug Saf. 2013 Nov; 22(11):1239-44. PMID: 24027140.
    Citations: 7     Fields:    Translation:Humans
  131. Toh S, Avorn J, D'Agostino RB, Gurwitz JH, Psaty BM, Rothman KJ, Saag KG, Sturkenboom MC, Vandenbroucke JP, Winterstein AG, Strom BL. Re-using Mini-Sentinel data following rapid assessments of potential safety signals via modular analytic programs. Pharmacoepidemiol Drug Saf. 2013 Oct; 22(10):1036-45. PMID: 23922322.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  132. Brown JS, Kahn M, Toh S. Data quality assessment for comparative effectiveness research in distributed data networks. Med Care. 2013 Aug; 51(8 Suppl 3):S22-9. PMID: 23793049.
    Citations: 61     Fields:    Translation:Humans
  133. Toh S, Gagne JJ, Rassen JA, Fireman BH, Kulldorff M, Brown JS. Confounding adjustment in comparative effectiveness research conducted within distributed research networks. Med Care. 2013 Aug; 51(8 Suppl 3):S4-10. PMID: 23752258.
    Citations: 31     Fields:    Translation:Humans
  134. Toh S, Reichman ME, Houstoun M, Ding X, Fireman BH, Gravel E, Levenson M, Li L, Moyneur E, Shoaibi A, Zornberg G, Hennessy S. Multivariable confounding adjustment in distributed data networks without sharing of patient-level data. Pharmacoepidemiol Drug Saf. 2013 Nov; 22(11):1171-7. PMID: 23878013.
    Citations: 17     Fields:    Translation:Humans
  135. Briesacher BA, Soumerai SB, Zhang F, Toh S, Andrade SE, Wagner JL, Shoaibi A, Gurwitz JH. A critical review of methods to evaluate the impact of FDA regulatory actions. Pharmacoepidemiol Drug Saf. 2013 Sep; 22(9):986-94. PMID: 23847020.
    Citations: 18     Fields:    Translation:PHPublic Health
  136. Lo Re V, Haynes K, Goldberg D, Forde KA, Carbonari DM, Leidl KB, Hennessy S, Reddy KR, Pawloski PA, Daniel GW, Cheetham TC, Iyer A, Coughlin KO, Toh S, Boudreau DM, Selvam N, Cooper WO, Selvan MS, VanWormer JJ, Avigan MI, Houstoun M, Zornberg GL, Racoosin JA, Shoaibi A. Validity of diagnostic codes to identify cases of severe acute liver injury in the US Food and Drug Administration's Mini-Sentinel Distributed Database. Pharmacoepidemiol Drug Saf. 2013 Aug; 22(8):861-72. PMID: 23801638.
    Citations: 31     Fields:    Translation:Humans
  137. Toh S, Baker MA, Brown JS, Kornegay C, Platt R. Rapid assessment of cardiovascular risk among users of smoking cessation drugs within the US Food and Drug Administration's Mini-Sentinel program. JAMA Intern Med. 2013 May 13; 173(9):817-9. PMID: 23529063.
    Citations: 16     Fields:    Translation:HumansPHPublic Health
  138. Toh S, Platt R. Is size the next big thing in epidemiology? Epidemiology. 2013 May; 24(3):349-51. PMID: 23549179.
    Citations: 20     Fields:    Translation:Humans
  139. Johnson KE, Beaton SJ, Andrade SE, Cheetham TC, Scott PE, Hammad TA, Dashevsky I, Cooper WO, Davis RL, Pawloski PA, Raebel MA, Smith DH, Toh S, Li DK, Haffenreffer K, Dublin S. Methods of linking mothers and infants using health plan data for studies of pregnancy outcomes. Pharmacoepidemiol Drug Saf. 2013 Jul; 22(7):776-82. PMID: 23596095.
    Citations: 8     Fields:    Translation:Humans
  140. Toh S, Li Q, Cheetham TC, Cooper WO, Davis RL, Dublin S, Hammad TA, Li DK, Pawloski PA, Pinheiro SP, Raebel MA, Scott PE, Smith DH, Bobo WV, Lawrence JM, Dashevsky I, Haffenreffer K, Avalos LA, Andrade SE. Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001-2007: a population-based study of 585,615 deliveries. Arch Womens Ment Health. 2013 Apr; 16(2):149-57. PMID: 23389622.
    Citations: 31     Fields:    Translation:HumansPHPublic Health
  141. Li Q, Andrade SE, Cooper WO, Davis RL, Dublin S, Hammad TA, Pawloski PA, Pinheiro SP, Raebel MA, Scott PE, Smith DH, Dashevsky I, Haffenreffer K, Johnson KE, Toh S. Validation of an algorithm to estimate gestational age in electronic health plan databases. Pharmacoepidemiol Drug Saf. 2013 May; 22(5):524-32. PMID: 23335117.
    Citations: 29     Fields:    Translation:Humans
  142. Lawrence JM, Andrade SE, Avalos LA, Beaton SJ, Chiu VY, Davis RL, Dublin S, Pawloski PA, Raebel MA, Smith DH, Toh S, Wang JQ, Kaplan S, Amini T, Hampp C, Hammad TA, Scott PE, Cheetham TC. Prevalence, trends, and patterns of use of antidiabetic medications among pregnant women, 2001-2007. Obstet Gynecol. 2013 Jan; 121(1):106-14. PMID: 23262934.
    Citations: 13     Fields:    Translation:Humans
  143. Toh S, Reichman ME, Houstoun M, Ross Southworth M, Ding X, Hernandez AF, Levenson M, Li L, McCloskey C, Shoaibi A, Wu E, Zornberg G, Hennessy S. Comparative risk for angioedema associated with the use of drugs that target the renin-angiotensin-aldosterone system. Arch Intern Med. 2012 Nov 12; 172(20):1582-9. PMID: 23147456.
    Citations: 55     Fields:    Translation:Humans
  144. Bobo WV, Davis RL, Toh S, Li DK, Andrade SE, Cheetham TC, Pawloski P, Dublin S, Pinheiro S, Hammad T, Scott PE, Epstein RA, Arbogast PG, Morrow JA, Dudley JA, Lawrence JM, Avalos LA, Cooper WO. Trends in the use of antiepileptic drugs among pregnant women in the US, 2001-2007: a medication exposure in pregnancy risk evaluation program study. Paediatr Perinat Epidemiol. 2012 Nov; 26(6):578-88. PMID: 23061694.
    Citations: 30     Fields:    Translation:Humans
  145. Andrade SE, Davis RL, Cheetham TC, Cooper WO, Li DK, Amini T, Beaton SJ, Dublin S, Hammad TA, Pawloski PA, Raebel MA, Smith DH, Staffa JA, Toh S, Dashevsky I, Haffenreffer K, Lane K, Platt R, Scott PE. Medication Exposure in Pregnancy Risk Evaluation Program. Matern Child Health J. 2012 Oct; 16(7):1349-54. PMID: 22002179.
    Citations: 20     Fields:    Translation:HumansPHPublic Health
  146. Andrade SE, Scott PE, Davis RL, Li DK, Getahun D, Cheetham TC, Raebel MA, Toh S, Dublin S, Pawloski PA, Hammad TA, Beaton SJ, Smith DH, Dashevsky I, Haffenreffer K, Cooper WO. Validity of health plan and birth certificate data for pregnancy research. Pharmacoepidemiol Drug Saf. 2013 Jan; 22(1):7-15. PMID: 22753079.
    Citations: 48     Fields:    Translation:Humans
  147. Cutrona SL, Toh S, Iyer A, Foy S, Daniel GW, Nair VP, Ng D, Butler MG, Boudreau D, Forrow S, Goldberg R, Gore J, McManus D, Racoosin JA, Gurwitz JH. Validation of acute myocardial infarction in the Food and Drug Administration's Mini-Sentinel program. Pharmacoepidemiol Drug Saf. 2013 Jan; 22(1):40-54. PMID: 22745038.
    Citations: 32     Fields:    Translation:Humans
  148. Toh S, García Rodríguez LA, Hernán MA. Analyzing partially missing confounder information in comparative effectiveness and safety research of therapeutics. Pharmacoepidemiol Drug Saf. 2012 May; 21 Suppl 2:13-20. PMID: 22552975.
    Citations: 11     Fields:    Translation:Humans
  149. Toh S, Li L, Harrold LR, Bayliss EA, Curtis JR, Liu L, Chen L, Grijalva CG, Herrinton LJ. Comparative safety of infliximab and etanercept on the risk of serious infections: does the association vary by patient characteristics? Pharmacoepidemiol Drug Saf. 2012 May; 21(5):524-34. PMID: 22411435.
    Citations: 13     Fields:    Translation:Humans
  150. Fireman B, Toh S, Butler MG, Go AS, Joffe HV, Graham DJ, Nelson JC, Daniel GW, Selby JV. A protocol for active surveillance of acute myocardial infarction in association with the use of a new antidiabetic pharmaceutical agent. Pharmacoepidemiol Drug Saf. 2012 Jan; 21 Suppl 1:282-90. PMID: 22262618.
    Citations: 10     Fields:    Translation:Humans
  151. Platt R, Carnahan RM, Brown JS, Chrischilles E, Curtis LH, Hennessy S, Nelson JC, Racoosin JA, Robb M, Schneeweiss S, Toh S, Weiner MG. The U.S. Food and Drug Administration's Mini-Sentinel program: status and direction. Pharmacoepidemiol Drug Saf. 2012 Jan; 21 Suppl 1:1-8. PMID: 22262586.
    Citations: 105     Fields:    Translation:Humans
  152. Gagne JJ, Fireman B, Ryan PB, Maclure M, Gerhard T, Toh S, Rassen JA, Nelson JC, Schneeweiss S. Design considerations in an active medical product safety monitoring system. Pharmacoepidemiol Drug Saf. 2012 Jan; 21 Suppl 1:32-40. PMID: 22262591.
    Citations: 20     Fields:    Translation:Humans
  153. Cutrona SL, Toh S, Iyer A, Foy S, Cavagnaro E, Forrow S, Racoosin JA, Goldberg R, Gurwitz JH. Design for validation of acute myocardial infarction cases in Mini-Sentinel. Pharmacoepidemiol Drug Saf. 2012 Jan; 21 Suppl 1:274-81. PMID: 22262617.
    Citations: 16     Fields:    Translation:Humans
  154. Toh S, Platt R, Steiner JF, Brown JS. Comparative-effectiveness research in distributed health data networks. Clin Pharmacol Ther. 2011 Dec; 90(6):883-7. PMID: 22030567.
    Citations: 30     Fields:    Translation:Humans
  155. Andrade SE, Moore Simas TA, Boudreau D, Raebel MA, Toh S, Syat B, Dashevsky I, Platt R. Validation of algorithms to ascertain clinical conditions and medical procedures used during pregnancy. Pharmacoepidemiol Drug Saf. 2011 Nov; 20(11):1168-76. PMID: 22020902.
    Citations: 16     Fields:    Translation:Humans
  156. Chen SY, Toh S. National trends in prescribing antidepressants before and after an FDA advisory on suicidality risk in youths. Psychiatr Serv. 2011 Jul; 62(7):727-33. PMID: 21724784.
    Citations: 5     Fields:    Translation:Humans
  157. Toh S, García Rodríguez LA, Hernán MA. Confounding adjustment via a semi-automated high-dimensional propensity score algorithm: an application to electronic medical records. Pharmacoepidemiol Drug Saf. 2011 Aug; 20(8):849-57. PMID: 21717528.
    Citations: 37     Fields:    Translation:Humans
  158. Chang CH, Toh S, Lin JW, Chen ST, Kuo CW, Chuang LM, Lai MS. Cancer risk associated with insulin glargine among adult type 2 diabetes patients--a nationwide cohort study. PLoS One. 2011; 6(6):e21368. PMID: 21738645.
    Citations: 28     Fields:    Translation:Humans
  159. Toh S, Mitchell AA, Anderka M, de Jong-van den Berg LT, Hernández-Díaz S. Antibiotics and oral contraceptive failure - a case-crossover study. Contraception. 2011 May; 83(5):418-25. PMID: 21477683.
    Citations: 6     Fields:    Translation:Humans
  160. Toh S, Hernández-Díaz S, Logan R, Robins JM, Hernán MA. Estimating absolute risks in the presence of nonadherence: an application to a follow-up study with baseline randomization. Epidemiology. 2010 Jul; 21(4):528-39. PMID: 20526200.
    Citations: 30     Fields:    Translation:Humans
  161. Toh S, Hernández-Díaz S, Logan R, Rossouw JE, Hernán MA. Coronary heart disease in postmenopausal recipients of estrogen plus progestin therapy: does the increased risk ever disappear? A randomized trial. Ann Intern Med. 2010 Feb 16; 152(4):211-7. PMID: 20157135.
    Citations: 30     Fields:    Translation:Humans
  162. Toh S, Mitchell AA, Louik C, Werler MM, Chambers CD, Hernández-Díaz S. Antidepressant use during pregnancy and the risk of preterm delivery and fetal growth restriction. J Clin Psychopharmacol. 2009 Dec; 29(6):555-60. PMID: 19910720.
    Citations: 22     Fields:    Translation:Humans
  163. Hernández-Díaz S, Toh S, Cnattingius S. Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study. BMJ. 2009 Jun 18; 338:b2255. PMID: 19541696.
    Citations: 139     Fields:    Translation:Humans
  164. Toh S, Mitchell AA, Louik C, Werler MM, Chambers CD, Hernández-Díaz S. Selective serotonin reuptake inhibitor use and risk of gestational hypertension. Am J Psychiatry. 2009 Mar; 166(3):320-8. PMID: 19122006.
    Citations: 31     Fields:    Translation:Humans
  165. Toh S, Hernán MA. Causal inference from longitudinal studies with baseline randomization. Int J Biostat. 2008 Oct 19; 4(1):Article 22. PMID: 20231914.
    Citations: 36     Fields:    Translation:Humans
  166. Toh S, Mitchell AA, Werler MM, Hernández-Díaz S. Sensitivity and specificity of computerized algorithms to classify gestational periods in the absence of information on date of conception. Am J Epidemiol. 2008 Mar 15; 167(6):633-40. PMID: 18194999.
    Citations: 29     Fields:    Translation:Humans
  167. Toh S, Rodríguez LA, Hernández-Díaz S. Use of antidepressants and risk of lung cancer. Cancer Causes Control. 2007 Dec; 18(10):1055-64. PMID: 17682831.
    Citations: 14     Fields:    Translation:Humans
  168. Toh S, Hernández-Díaz S. Statins and fracture risk. A systematic review. Pharmacoepidemiol Drug Saf. 2007 Jun; 16(6):627-40. PMID: 17286319.
    Citations: 20     Fields:    Translation:HumansAnimals
  169. Toh S. Datapoints: trends in ADHD and stimulant use among children, 1993-2003. Psychiatr Serv. 2006 Aug; 57(8):1091. PMID: 16870957.
    Citations: 5     Fields:    Translation:Humans
  170. Lin SJ, Lambert BL, Tan H, Toh S. Frequency estimates from prescription drug datasets. Pharmacoepidemiol Drug Saf. 2005; 15:512-520.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.