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Robert Lawrence Martuza, M.D.


Efficacy of Genetically Engineered ICP6 Mutant Herpes Simplex Viral Vectors for the Treatment of Malignant Glioma
Summer, 04/03/06 - 08/10/06

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R25NS065743 (CASH, SYDNEY S) Mar 4, 2009 - Jun 30, 2024
    Neuroscience Resident Research Program
    Role: Co-Principal Investigator
  2. R01CA102139 (MARTUZA, ROBERT L) Jul 1, 2003 - Nov 30, 2015
    Genetically Engineered Viruses for Prostate Cancer Therapy
    Role: Principal Investigator
  3. K12CA090354 (BATCHELOR, TRACY T) Sep 26, 2001 - Aug 31, 2021
    Training Program in Nervous System Tumors
    Role: Co-Principal Investigator
  4. P30CA006516 (GLIMCHER, LAURIE HOLLIS) Mar 10, 1997 - Sep 29, 2012
    Dana-Farber/Harvard Cancer Center
    Role: Co-Principal Investigator
  5. R01NS032677 (MARTUZA, ROBERT L) May 1, 1994 - Nov 30, 2022
    Genetically Engineered Viruses for Brain Tumor Therapy
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Saha D, Rabkin SD, Martuza RL. Temozolomide antagonizes oncolytic immunovirotherapy in glioblastoma. J Immunother Cancer. 2020 May; 8(1). PMID: 32457126.
  2. Lamba N, Hwang WL, Kim DW, Niemierko A, Marciscano AE, Mehan WA, Benayoun MD, Curry WT, Barker FG, Martuza RL, Dunn IF, Claus E, Bi WL, Aizer AA, Alexander BM, Oh KS, Loeffler JS, Shih HA. Atypical Histopathological Features and the Risk of Treatment Failure in Nonmalignant Meningiomas: A Multi-Institutional Analysis. World Neurosurg. 2020 Jan; 133:e804-e812. PMID: 31605839.
  3. Nigim F, Kiyokawa J, Gurtner A, Kawamura Y, Hua L, Kasper EM, Brastianos PK, Cahill DP, Rabkin SD, Martuza RL, Carbonell WS, Wakimoto H. A Monoclonal Antibody Against ß1 Integrin Inhibits Proliferation and Increases Survival in an Orthotopic Model of High-Grade Meningioma. Target Oncol. 2019 08; 14(4):479-489. PMID: 31301014.
  4. Ning JF, Stanciu M, Humphrey MR, Gorham J, Wakimoto H, Nishihara R, Lees J, Zou L, Martuza RL, Wakimoto H, Rabkin SD. Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma. Nat Commun. 2019 07 02; 10(1):2910. PMID: 31266951.
  5. Wang L, Ning J, Wakimoto H, Wu S, Wu CL, Humphrey MR, Rabkin SD, Martuza RL. Oncolytic Herpes Simplex Virus and PI3K Inhibitor BKM120 Synergize to Promote Killing of Prostate Cancer Stem-like Cells. Mol Ther Oncolytics. 2019 Jun 28; 13:58-66. PMID: 31016228.
  6. Chongsathidkiet P, Jackson C, Koyama S, Loebel F, Cui X, Farber SH, Woroniecka K, Elsamadicy AA, Dechant CA, Kemeny HR, Sanchez-Perez L, Cheema TA, Souders NC, Herndon JE, Coumans JV, Everitt JI, Nahed BV, Sampson JH, Gunn MD, Martuza RL, Dranoff G, Curry WT, Fecci PE. Author Correction: Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors. Nat Med. 2019 Mar; 25(3):529. PMID: 30670876.
    Citations:    Fields:    
  7. Arrillaga-Romany I, Curry WT, Jordan JT, Cahill DP, Nahed BV, Martuza RL, Loeffler JS, Järhult SJ, Muzikansky A, Cohen AB, Singhal AB, Goldstein JN, Batchelor TT. Performance of a Hospital Pathway for Patients With a New Single Brain Mass. J Oncol Pract. 2019 Mar; 15(3):e211-e218. PMID: 30681891.
    Citations:    Fields:    
  8. Tanaka S, Luk S, Kiyokawa J, Onozato ML, Iafrate AJ, Shah K, Martuza RL, Rabkin SD, Batchelor TT, Cahill DP, Chi AS, Wakimoto H. Genetically distinct glioma stem-like cell xenografts established from paired glioblastoma samples harvested before and after molecularly targeted therapy. Sci Rep. 2019 01 15; 9(1):139. PMID: 30644426.
    Citations:    Fields:    
  9. Chongsathidkiet P, Jackson C, Koyama S, Loebel F, Cui X, Farber SH, Woroniecka K, Elsamadicy AA, Dechant CA, Kemeny HR, Sanchez-Perez L, Cheema TA, Souders NC, Herndon JE, Coumans JV, Everitt JI, Nahed BV, Sampson JH, Gunn MD, Martuza RL, Dranoff G, Curry WT, Fecci PE. Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors. Nat Med. 2018 09; 24(9):1459-1468. PMID: 30104766.
    Citations: 3     Fields:    
  10. Peters C, Paget M, Tshilenge KT, Saha D, Antoszczyk S, Baars A, Frost T, Martuza RL, Wakimoto H, Rabkin SD. Restriction of Replication of Oncolytic Herpes Simplex Virus with a Deletion of ?34.5 in Glioblastoma Stem-Like Cells. J Virol. 2018 08 01; 92(15). PMID: 29793956.
    Citations:    Fields:    
  11. Saha D, Martuza RL, Rabkin SD. Oncolytic herpes simplex virus immunovirotherapy in combination with immune checkpoint blockade to treat glioblastoma. Immunotherapy. 2018 07; 10(9):779-786. PMID: 30008259.
    Citations:    Fields:    
  12. Saha D, Wakimoto H, Peters CW, Antoszczyk SJ, Rabkin SD, Martuza RL. Combinatorial Effects of VEGFR Kinase Inhibitor Axitinib and Oncolytic Virotherapy in Mouse and Human Glioblastoma Stem-Like Cell Models. Clin Cancer Res. 2018 07 15; 24(14):3409-3422. PMID: 29599413.
    Citations:    Fields:    
  13. Saha D, Martuza RL, Rabkin SD. Curing glioblastoma: oncolytic HSV-IL12 and checkpoint blockade. Oncoscience. 2017 Jul; 4(7-8):67-69. PMID: 28966936.
    Citations: 2     
  14. Esaki S, Nigim F, Moon E, Luk S, Kiyokawa J, Curry W, Cahill DP, Chi AS, Iafrate AJ, Martuza RL, Rabkin SD, Wakimoto H. Blockade of transforming growth factor-ß signaling enhances oncolytic herpes simplex virus efficacy in patient-derived recurrent glioblastoma models. Int J Cancer. 2017 12 01; 141(11):2348-2358. PMID: 28801914.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  15. Saha D, Martuza RL, Rabkin SD. Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade. Cancer Cell. 2017 08 14; 32(2):253-267.e5. PMID: 28810147.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  16. Kim D, Niemierko A, Hwang WL, Stemmer-Rachamimov AO, Curry WT, Barker FG, Martuza RL, Oh KS, Loeffler JS, Shih HA. Histopathological prognostic factors of recurrence following definitive therapy for atypical and malignant meningiomas. J Neurosurg. 2018 04; 128(4):1123-1132. PMID: 28621619.
    Citations: 1     Fields:    
  17. Ning J, Wakimoto H, Peters C, Martuza RL, Rabkin SD. Rad51 Degradation: Role in Oncolytic Virus-Poly(ADP-Ribose) Polymerase Inhibitor Combination Therapy in Glioblastoma. J Natl Cancer Inst. 2017 03 01; 109(3):1-13. PMID: 28376211.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  18. Tirosh I, Venteicher AS, Hebert C, Escalante LE, Patel AP, Yizhak K, Fisher JM, Rodman C, Mount C, Filbin MG, Neftel C, Desai N, Nyman J, Izar B, Luo CC, Francis JM, Patel AA, Onozato ML, Riggi N, Livak KJ, Gennert D, Satija R, Nahed BV, Curry WT, Martuza RL, Mylvaganam R, Iafrate AJ, Frosch MP, Golub TR, Rivera MN, Getz G, Rozenblatt-Rosen O, Cahill DP, Monje M, Bernstein BE, Louis DN, Regev A, Suvà ML. Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma. Nature. 2016 11 10; 539(7628):309-313. PMID: 27806376.
    Citations: 60     Fields:    Translation:HumansCells
  19. Venteicher AS, Tirosh I, Hebert C, Escalante L, Martuza RL, Nahed BV, Curry WT, Cahill DP, Bernstein B, Louis DN, Regev A, Suva M. 142 Genetic and Nongenetic Determinants of Cellular Architecture in IDH1-Mutant Oligodendrogliomas and Astrocytomas Using Single-Cell Transcriptome Analysis. Neurosurgery. 2016 Aug; 63 Suppl 1:158. PMID: 27399421.
  20. Nigim F, Esaki S, Hood M, Lelic N, James MF, Ramesh V, Stemmer-Rachamimov A, Cahill DP, Brastianos PK, Rabkin SD, Martuza RL, Wakimoto H. A new patient-derived orthotopic malignant meningioma model treated with oncolytic herpes simplex virus. Neuro Oncol. 2016 09; 18(9):1278-87. PMID: 26951380.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  21. Esaki S, Rabkin SD, Martuza RL, Wakimoto H. Transient fasting enhances replication of oncolytic herpes simplex virus in glioblastoma. Am J Cancer Res. 2016; 6(2):300-11. PMID: 27186404.
    Citations: 3     
  22. Hwang WL, Marciscano AE, Niemierko A, Kim DW, Stemmer-Rachamimov AO, Curry WT, Barker FG, Martuza RL, Loeffler JS, Oh KS, Shih HA, Larvie M. Imaging and extent of surgical resection predict risk of meningioma recurrence better than WHO histopathological grade. Neuro Oncol. 2016 06; 18(6):863-72. PMID: 26597949.
    Citations: 11     Fields:    Translation:Humans
  23. Marciscano AE, Stemmer-Rachamimov AO, Niemierko A, Larvie M, Curry WT, Barker FG, Martuza RL, McGuone D, Oh KS, Loeffler JS, Shih HA. Benign meningiomas (WHO Grade I) with atypical histological features: correlation of histopathological features with clinical outcomes. J Neurosurg. 2016 Jan; 124(1):106-14. PMID: 26274991.
    Citations: 5     Fields:    Translation:Humans
  24. Nigim F, Cavanaugh J, Patel AP, Curry WT, Esaki S, Kasper EM, Chi AS, Louis DN, Martuza RL, Rabkin SD, Wakimoto H. Targeting Hypoxia-Inducible Factor 1a in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment. J Neuropathol Exp Neurol. 2015 Jul; 74(7):710-22. PMID: 26083570.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  25. Lu L, Saha D, Martuza RL, Rabkin SD, Wakimoto H. Single agent efficacy of the VEGFR kinase inhibitor axitinib in preclinical models of glioblastoma. J Neurooncol. 2015 Jan; 121(1):91-100. PMID: 25213669.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  26. Patel AP, Tirosh I, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, Cahill DP, Nahed BV, Curry WT, Martuza RL, Louis DN, Rozenblatt-Rosen O, Suvà ML, Regev A, Bernstein BE. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science. 2014 Jun 20; 344(6190):1396-401. PMID: 24925914.
    Citations: 519     Fields:    Translation:Humans
  27. Suvà ML, Rheinbay E, Gillespie SM, Patel AP, Wakimoto H, Rabkin SD, Riggi N, Chi AS, Cahill DP, Nahed BV, Curry WT, Martuza RL, Rivera MN, Rossetti N, Kasif S, Beik S, Kadri S, Tirosh I, Wortman I, Shalek AK, Rozenblatt-Rosen O, Regev A, Louis DN, Bernstein BE. Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells. Cell. 2014 Apr 24; 157(3):580-94. PMID: 24726434.
    Citations: 186     Fields:    Translation:HumansCells
  28. Antoszczyk S, Spyra M, Mautner VF, Kurtz A, Stemmer-Rachamimov AO, Martuza RL, Rabkin SD. Treatment of orthotopic malignant peripheral nerve sheath tumors with oncolytic herpes simplex virus. Neuro Oncol. 2014 Aug; 16(8):1057-66. PMID: 24470552.
    Citations: 9     Fields:    Translation:AnimalsCells
  29. Sheth SA, Tirino JL, Martuza RL. Vestibular schwannoma: suboccipital approach. Neurosurg Focus. 2014 Jan; 36(1 Suppl):1. PMID: 24380512.
    Citations:    Fields:    Translation:Humans
  30. Fecci P, Chen C, Koyama S, Dranoff G, Martuza RL, Curry WT. 198 Of Mice and Men: Matched Observations of Lymphopenia, Splenic Retraction, and the Bone Marrow as Harbor for Lost T-cells in Mice and Patients With Glioblastoma. Neurosurgery. 2013 Aug; 60 Suppl 1:185-6. PMID: 23839465.
  31. Cheema TA, Wakimoto H, Fecci PE, Ning J, Kuroda T, Jeyaretna DS, Martuza RL, Rabkin SD. Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):12006-11. PMID: 23754388.
    Citations: 40     Fields:    Translation:AnimalsCells
  32. Zhang W, Fulci G, Wakimoto H, Cheema TA, Buhrman JS, Jeyaretna DS, Stemmer Rachamimov AO, Rabkin SD, Martuza RL. Combination of oncolytic herpes simplex viruses armed with angiostatin and IL-12 enhances antitumor efficacy in human glioblastoma models. Neoplasia. 2013 Jun; 15(6):591-9. PMID: 23730207.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  33. Rheinbay E, Suvà ML, Gillespie SM, Wakimoto H, Patel AP, Shahid M, Oksuz O, Rabkin SD, Martuza RL, Rivera MN, Louis DN, Kasif S, Chi AS, Bernstein BE. An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma. Cell Rep. 2013 May 30; 3(5):1567-79. PMID: 23707066.
    Citations: 59     Fields:    Translation:HumansCells
  34. Las Heras F, Martuza R, Caruso P, Rincon S, Stemmer-Rachamimov A. 24-year-old woman with an internal auditory canal mass. Hybrid peripheral nerve sheath tumor with schwannoma/perineurioma components. Brain Pathol. 2013 May; 23(3):361-2. PMID: 23587143.
    Citations: 1     Fields:    Translation:Humans
  35. Passer BJ, Cheema T, Wu S, Wu CL, Rabkin SD, Martuza RL. Combination of vinblastine and oncolytic herpes simplex virus vector expressing IL-12 therapy increases antitumor and antiangiogenic effects in prostate cancer models. Cancer Gene Ther. 2013 Jan; 20(1):17-24. PMID: 23138870.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  36. Barnard Z, Wakimoto H, Zaupa C, Patel AP, Klehm J, Martuza RL, Rabkin SD, Curry WT. Expression of FMS-like tyrosine kinase 3 ligand by oncolytic herpes simplex virus type I prolongs survival in mice bearing established syngeneic intracranial malignant glioma. Neurosurgery. 2012 Sep; 71(3):741-8; discussion 748. PMID: 22653387.
    Citations: 8     Fields:    Translation:AnimalsCells
  37. Ginat DT, Martuza RL. Postoperative imaging of vestibular schwannomas. Neurosurg Focus. 2012 Sep; 33(3):E18. PMID: 22937852.
    Citations: 3     Fields:    Translation:Humans
  38. Tamura K, Wakimoto H, Agarwal AS, Rabkin SD, Bhere D, Martuza RL, Kuroda T, Kasmieh R, Shah K. Multimechanistic tumor targeted oncolytic virus overcomes resistance in brain tumors. Mol Ther. 2013 Jan; 21(1):68-77. PMID: 22929661.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  39. Peterfreund RA, Luman E, Martuza RL. Anesthesia for suboccipital craniotomy in a patient with lymphangioleiomyomatosis: a case report. Case Rep Pulmonol. 2012; 2012:804789. PMID: 22934225.
  40. Sgubin D, Wakimoto H, Kanai R, Rabkin SD, Martuza RL. Oncolytic herpes simplex virus counteracts the hypoxia-induced modulation of glioblastoma stem-like cells. Stem Cells Transl Med. 2012 Apr; 1(4):322-32. PMID: 23197811.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  41. Kanai R, Zaupa C, Sgubin D, Antoszczyk SJ, Martuza RL, Wakimoto H, Rabkin SD. Effect of ?34.5 deletions on oncolytic herpes simplex virus activity in brain tumors. J Virol. 2012 Apr; 86(8):4420-31. PMID: 22345479.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  42. Kanai R, Rabkin SD, Yip S, Sgubin D, Zaupa CM, Hirose Y, Louis DN, Wakimoto H, Martuza RL. Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells. J Natl Cancer Inst. 2012 Jan 04; 104(1):42-55. PMID: 22173583.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  43. Wakimoto H, Mohapatra G, Kanai R, Curry WT, Yip S, Nitta M, Patel AP, Barnard ZR, Stemmer-Rachamimov AO, Louis DN, Martuza RL, Rabkin SD. Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells. Neuro Oncol. 2012 Feb; 14(2):132-44. PMID: 22067563.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  44. Cheema TA, Kanai R, Kim GW, Wakimoto H, Passer B, Rabkin SD, Martuza RL. Enhanced antitumor efficacy of low-dose Etoposide with oncolytic herpes simplex virus in human glioblastoma stem cell xenografts. Clin Cancer Res. 2011 Dec 01; 17(23):7383-93. PMID: 21976549.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  45. Zhang W, Fulci G, Buhrman JS, Stemmer-Rachamimov AO, Chen JW, Wojtkiewicz GR, Weissleder R, Rabkin SD, Martuza RL. Bevacizumab with angiostatin-armed oHSV increases antiangiogenesis and decreases bevacizumab-induced invasion in U87 glioma. Mol Ther. 2012 Jan; 20(1):37-45. PMID: 21915104.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  46. Kleijn A, Chen JW, Buhrman JS, Wojtkiewicz GR, Iwamoto Y, Lamfers ML, Stemmer-Rachamimov AO, Rabkin SD, Weissleder R, Martuza RL, Fulci G. Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging. Clin Cancer Res. 2011 Jul 01; 17(13):4484-93. PMID: 21558403.
    Citations: 11     Fields:    Translation:AnimalsCells
  47. Kanai R, Wakimoto H, Martuza RL, Rabkin SD. A novel oncolytic herpes simplex virus that synergizes with phosphoinositide 3-kinase/Akt pathway inhibitors to target glioblastoma stem cells. Clin Cancer Res. 2011 Jun 01; 17(11):3686-96. PMID: 21505062.
    Citations: 36     Fields:    Translation:AnimalsCells
  48. Elstner A, Stockhammer F, Nguyen-Dobinsky TN, Nguyen QL, Pilgermann I, Gill A, Guhr A, Zhang T, von Eckardstein K, Picht T, Veelken J, Martuza RL, von Deimling A, Kurtz A. Identification of diagnostic serum protein profiles of glioblastoma patients. J Neurooncol. 2011 Mar; 102(1):71-80. PMID: 20617365.
    Citations: 7     Fields:    Translation:Humans
  49. Passer BJ, Cheema T, Zhou B, Wakimoto H, Zaupa C, Razmjoo M, Sarte J, Wu S, Wu CL, Noah JW, Li Q, Buolamwini JK, Yen Y, Rabkin SD, Martuza RL. Identification of the ENT1 antagonists dipyridamole and dilazep as amplifiers of oncolytic herpes simplex virus-1 replication. Cancer Res. 2010 May 15; 70(10):3890-5. PMID: 20424118.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  50. Castelo-Branco P, Passer BJ, Buhrman JS, Antoszczyk S, Marinelli M, Zaupa C, Rabkin SD, Martuza RL. Oncolytic herpes simplex virus armed with xenogeneic homologue of prostatic acid phosphatase enhances antitumor efficacy in prostate cancer. Gene Ther. 2010 Jun; 17(6):805-10. PMID: 20220784.
    Citations: 13     Fields:    Translation:AnimalsCellsPHPublic Health
  51. Passer BJ, Wu CL, Wu S, Rabkin SD, Martuza RL. Analysis of genetically engineered oncolytic herpes simplex viruses in human prostate cancer organotypic cultures. Gene Ther. 2009 Dec; 16(12):1477-82. PMID: 19693098.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  52. Stankovic KM, Mrugala MM, Martuza RL, Silver M, Betensky RA, Nadol JB, Stemmer-Rachamimov AO. Genetic determinants of hearing loss associated with vestibular schwannomas. Otol Neurotol. 2009 Aug; 30(5):661-7. PMID: 19546833.
    Citations: 8     Fields:    Translation:HumansCells
  53. Wakimoto H, Kesari S, Farrell CJ, Curry WT, Zaupa C, Aghi M, Kuroda T, Stemmer-Rachamimov A, Shah K, Liu TC, Jeyaretna DS, Debasitis J, Pruszak J, Martuza RL, Rabkin SD. Human glioblastoma-derived cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors. Cancer Res. 2009 Apr 15; 69(8):3472-81. PMID: 19351838.
    Citations: 138     Fields:    Translation:HumansAnimalsCells
  54. Sasportas LS, Kasmieh R, Wakimoto H, Hingtgen S, van de Water JA, Mohapatra G, Figueiredo JL, Martuza RL, Weissleder R, Shah K. Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4822-7. PMID: 19264968.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  55. Passer BJ, Castelo-Branco P, Buhrman JS, Varghese S, Rabkin SD, Martuza RL. Oncolytic herpes simplex virus vectors and taxanes synergize to promote killing of prostate cancer cells. Cancer Gene Ther. 2009 Jul; 16(7):551-60. PMID: 19197321.
    Citations: 18     Fields:    Translation:HumansCells
  56. Aghi MK, Carter BS, Cosgrove GR, Ojemann RG, Amin-Hanjani S, Martuza RL, Curry WT, Barker FG. Long-term recurrence rates of atypical meningiomas after gross total resection with or without postoperative adjuvant radiation. Neurosurgery. 2009 Jan; 64(1):56-60; discussion 60. PMID: 19145156.
    Citations: 59     Fields:    Translation:Humans
  57. Farrell CJ, Zaupa C, Barnard Z, Maley J, Martuza RL, Rabkin SD, Curry WT. Combination immunotherapy for tumors via sequential intratumoral injections of oncolytic herpes simplex virus 1 and immature dendritic cells. Clin Cancer Res. 2008 Dec 01; 14(23):7711-6. PMID: 19047097.
    Citations: 12     Fields:    Translation:AnimalsCells
  58. Farassati F, Pan W, Yamoutpour F, Henke S, Piedra M, Frahm S, Al-Tawil S, Mangrum WI, Parada LF, Rabkin SD, Martuza RL, Kurtz A. Ras signaling influences permissiveness of malignant peripheral nerve sheath tumor cells to oncolytic herpes. Am J Pathol. 2008 Dec; 173(6):1861-72. PMID: 18988803.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  59. Aghi MK, Liu TC, Rabkin S, Martuza RL. Hypoxia enhances the replication of oncolytic herpes simplex virus. Mol Ther. 2009 Jan; 17(1):51-6. PMID: 18957963.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  60. Liu TC, Castelo-Branco P, Rabkin SD, Martuza RL. Trichostatin A and oncolytic HSV combination therapy shows enhanced antitumoral and antiangiogenic effects. Mol Ther. 2008 Jun; 16(6):1041-7. PMID: 18388912.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  61. Sher DJ, Henson JW, Avutu B, Hochberg FH, Batchelor TT, Martuza RL, Barker FG, Loeffler JS, Chakravarti A. The added value of concurrently administered temozolomide versus adjuvant temozolomide alone in newly diagnosed glioblastoma. J Neurooncol. 2008 May; 88(1):43-50. PMID: 18231723.
    Citations: 14     Fields:    Translation:Humans
  62. Liu TC, Wakimoto H, Martuza RL, Rabkin SD. Herpes simplex virus Us3(-) mutant as oncolytic strategy and synergizes with phosphatidylinositol 3-kinase-Akt targeting molecular therapeutics. Clin Cancer Res. 2007 Oct 01; 13(19):5897-902. PMID: 17908985.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  63. Fulci G, Dmitrieva N, Gianni D, Fontana EJ, Pan X, Lu Y, Kaufman CS, Kaur B, Lawler SE, Lee RJ, Marsh CB, Brat DJ, van Rooijen N, Stemmer-Rachamimov AO, Rachamimov AS, Hochberg FH, Weissleder R, Martuza RL, Chiocca EA. Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses. Cancer Res. 2007 Oct 01; 67(19):9398-406. PMID: 17909049.
    Citations: 59     Fields:    Translation:AnimalsCells
  64. Varghese S, Rabkin SD, Nielsen GP, MacGarvey U, Liu R, Martuza RL. Systemic therapy of spontaneous prostate cancer in transgenic mice with oncolytic herpes simplex viruses. Cancer Res. 2007 Oct 01; 67(19):9371-9. PMID: 17909046.
    Citations: 19     Fields:    Translation:AnimalsCells
  65. Jeyaretna DS, Rabkin SD, Martuza RL. Oncolytic herpes simplex virus therapy for peripheral nerve tumors. Neurosurg Focus. 2007 Jun 15; 22(6):E4. PMID: 17613221.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  66. Prabhakar S, Messerli SM, Stemmer-Rachamimov AO, Liu TC, Rabkin S, Martuza R, Breakefield XO. Treatment of implantable NF2 schwannoma tumor models with oncolytic herpes simplex virus G47Delta. Cancer Gene Ther. 2007 May; 14(5):460-7. PMID: 17304235.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  67. Aghi M, Rabkin SD, Martuza RL. Angiogenic response caused by oncolytic herpes simplex virus-induced reduced thrombospondin expression can be prevented by specific viral mutations or by administering a thrombospondin-derived peptide. Cancer Res. 2007 Jan 15; 67(2):440-4. PMID: 17234749.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  68. Liu TC, Zhang T, Fukuhara H, Kuroda T, Todo T, Canron X, Bikfalvi A, Martuza RL, Kurtz A, Rabkin SD. Dominant-negative fibroblast growth factor receptor expression enhances antitumoral potency of oncolytic herpes simplex virus in neural tumors. Clin Cancer Res. 2006 Nov 15; 12(22):6791-9. PMID: 17121900.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  69. Kuroda T, Rabkin SD, Martuza RL. Effective treatment of tumors with strong beta-catenin/T-cell factor activity by transcriptionally targeted oncolytic herpes simplex virus vector. Cancer Res. 2006 Oct 15; 66(20):10127-35. PMID: 17047077.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  70. Liu TC, Zhang T, Fukuhara H, Kuroda T, Todo T, Martuza RL, Rabkin SD, Kurtz A. Oncolytic HSV armed with platelet factor 4, an antiangiogenic agent, shows enhanced efficacy. Mol Ther. 2006 Dec; 14(6):789-97. PMID: 17045531.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  71. Martuza RL. Vestibular schwannoma. J Neurosurg. 2006 Oct; 105(4):526; discussion 526. PMID: 17044552.
    Citations: 1     Fields:    Translation:Humans
  72. Kuroda T, Martuza RL, Todo T, Rabkin SD. Flip-Flop HSV-BAC: bacterial artificial chromosome based system for rapid generation of recombinant herpes simplex virus vectors using two independent site-specific recombinases. BMC Biotechnol. 2006 Sep 22; 6:40. PMID: 16995942.
    Citations: 21     Fields:    Translation:Cells
  73. Varghese S, Rabkin SD, Nielsen PG, Wang W, Martuza RL. Systemic oncolytic herpes virus therapy of poorly immunogenic prostate cancer metastatic to lung. Clin Cancer Res. 2006 May 01; 12(9):2919-27. PMID: 16675589.
    Citations: 13     Fields:    Translation:AnimalsCells
  74. Varghese S, Rabkin SD, Liu R, Nielsen PG, Ipe T, Martuza RL. Enhanced therapeutic efficacy of IL-12, but not GM-CSF, expressing oncolytic herpes simplex virus for transgenic mouse derived prostate cancers. Cancer Gene Ther. 2006 Mar; 13(3):253-65. PMID: 16179929.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  75. Aghi M, Rabkin S, Martuza RL. Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication. J Natl Cancer Inst. 2006 Jan 04; 98(1):38-50. PMID: 16391370.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  76. Messerli SM, Prabhakar S, Tang Y, Mahmood U, Giovannini M, Weissleder R, Bronson R, Martuza R, Rabkin S, Breakefield XO. Treatment of schwannomas with an oncolytic recombinant herpes simplex virus in murine models of neurofibromatosis type 2. Hum Gene Ther. 2006 Jan; 17(1):20-30. PMID: 16409122.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  77. Aghi M, Rabkin S, Martuza RL. Oncolytic herpes simplex virus mutants exhibit enhanced replication in glioma cells evading temozolomide chemotherapy through deoxyribonucleic acid repair. Clin Neurosurg. 2006; 53:65-76. PMID: 17380741.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  78. Fukuhara H, Ino Y, Kuroda T, Martuza RL, Todo T. Triple gene-deleted oncolytic herpes simplex virus vector double-armed with interleukin 18 and soluble B7-1 constructed by bacterial artificial chromosome-mediated system. Cancer Res. 2005 Dec 01; 65(23):10663-8. PMID: 16322208.
    Citations: 32     Fields:    Translation:AnimalsCells
  79. Aghi M, Martuza RL. Oncolytic viral therapies - the clinical experience. Oncogene. 2005 Nov 21; 24(52):7802-16. PMID: 16299539.
    Citations: 93     Fields:    Translation:HumansCells
  80. Fukuhara H, Martuza RL, Rabkin SD, Ito Y, Todo T. Oncolytic herpes simplex virus vector g47delta in combination with androgen ablation for the treatment of human prostate adenocarcinoma. Clin Cancer Res. 2005 Nov 01; 11(21):7886-90. PMID: 16278413.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  81. Aghi MK, Rabkin S, Martuza RL. 840 Enhanced Replication of Oncolytic Herpes Simplex Virus in Glioma Cells that Evade Temozolomide Chemotherapy through DNA Repair. Neurosurgery. 2005 Aug 01; 57(2):408-409. PMID: 28184805.
  82. Chan AW, Black P, Ojemann RG, Barker FG, Kooy HM, Lopes VV, McKenna MJ, Shrieve DC, Martuza RL, Loeffler JS. Stereotactic radiotherapy for vestibular schwannomas: favorable outcome with minimal toxicity. Neurosurgery. 2005 Jul; 57(1):60-70; discussion 60-70. PMID: 15987541.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  83. Mashour GA, Walker EE, Martuza RL. Psychosurgery: past, present, and future. Brain Res Brain Res Rev. 2005 Jun; 48(3):409-19. PMID: 15914249.
    Citations: 17     Fields:    Translation:Humans
  84. Liu R, Martuza RL, Rabkin SD. Intracarotid delivery of oncolytic HSV vector G47Delta to metastatic breast cancer in the brain. Gene Ther. 2005 Apr; 12(8):647-54. PMID: 15647762.
    Citations: 24     Fields:    Translation:AnimalsCells
  85. Mashour GA, Drissel SN, Frahm S, Farassati F, Martuza RL, Mautner VF, Kindler-Röhrborn A, Kurtz A. Differential modulation of malignant peripheral nerve sheath tumor growth by omega-3 and omega-6 fatty acids. Oncogene. 2005 Mar 31; 24(14):2367-74. PMID: 15735744.
    Citations: 2     Fields:    Translation:AnimalsCells
  86. Doolittle ND, Abrey LE, Bleyer WA, Brem S, Davis TP, Dore-Duffy P, Drewes LR, Hall WA, Hoffman JM, Korfel A, Martuza R, Muldoon LL, Peereboom D, Peterson DR, Rabkin SD, Smith Q, Stevens GH, Neuwelt EA. New frontiers in translational research in neuro-oncology and the blood-brain barrier: report of the tenth annual Blood-Brain Barrier Disruption Consortium Meeting. Clin Cancer Res. 2005 Jan 15; 11(2 Pt 1):421-8. PMID: 15701824.
    Citations: 12     Fields:    Translation:Humans
  87. Mashour GA, Driever PH, Hartmann M, Drissel SN, Zhang T, Scharf B, Felderhoff-Müser U, Sakuma S, Friedrich RE, Martuza RL, Mautner VF, Kurtz A. Circulating growth factor levels are associated with tumorigenesis in neurofibromatosis type 1. Clin Cancer Res. 2004 Sep 01; 10(17):5677-83. PMID: 15355893.
    Citations: 14     Fields:    Translation:HumansCells
  88. Kurtz A, Lueth M, Kluwe L, Zhang T, Foster R, Mautner VF, Hartmann M, Tan DJ, Martuza RL, Friedrich RE, Driever PH, Wong LJ. Somatic mitochondrial DNA mutations in neurofibromatosis type 1-associated tumors. Mol Cancer Res. 2004 Aug; 2(8):433-41. PMID: 15328370.
    Citations: 12     Fields:    Translation:HumansCells
  89. Weber DC, Chan AW, Bussiere MR, Harsh GR, Ancukiewicz M, Barker FG, Thornton AT, Martuza RL, Nadol JB, Chapman PH, Loeffler JS. Proton beam radiosurgery for vestibular schwannoma: tumor control and cranial nerve toxicity. Neurosurgery. 2003 Sep; 53(3):577-86; discussion 586-8. PMID: 12943574.
    Citations: 5     Fields:    Translation:Humans
  90. Nikolic B, Feigenbaum F, Abbara S, Martuza RL, Schellinger D. CT changes of an intracranial granulocytic sarcoma on short-term follow-up. AJR Am J Roentgenol. 2003 Jan; 180(1):78-80. PMID: 12490481.
    Citations: 3     Fields:    Translation:Humans
  91. Kurtz A, Martuza RL. Antiangiogenesis in neurofibromatosis 1. J Child Neurol. 2002 Aug; 17(8):578-84; discussion 602-4, 646-51. PMID: 12403556.
    Citations: 2     Fields:    Translation:HumansAnimals
  92. Jorgensen TJ, Katz S, Wittmack EK, Varghese S, Todo T, Rabkin SD, Martuza RL. Ionizing radiation does not alter the antitumor activity of herpes simplex virus vector G207 in subcutaneous tumor models of human and murine prostate cancer. Neoplasia. 2001 Sep-Oct; 3(5):451-6. PMID: 11687957.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  93. Kirn D, Martuza RL, Zwiebel J. Replication-selective virotherapy for cancer: Biological principles, risk management and future directions. Nat Med. 2001 Jul; 7(7):781-7. PMID: 11433341.
    Citations: 106     Fields:    Translation:HumansCells
  94. Varghese S, Newsome JT, Rabkin SD, McGeagh K, Mahoney D, Nielsen P, Todo T, Martuza RL. Preclinical safety evaluation of G207, a replication-competent herpes simplex virus type 1, inoculated intraprostatically in mice and nonhuman primates. Hum Gene Ther. 2001 May 20; 12(8):999-1010. PMID: 11387063.
    Citations: 16     Fields:    Translation:AnimalsCells
  95. Todo T, Martuza RL, Rabkin SD, Johnson PA. Oncolytic herpes simplex virus vector with enhanced MHC class I presentation and tumor cell killing. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6396-401. PMID: 11353831.
    Citations: 96     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  96. Mashour GA, Moulding HD, Chahlavi A, Khan GA, Rabkin SD, Martuza RL, Driever PH, Kurtz A, Chalavi A. Therapeutic efficacy of G207 in a novel peripheral nerve sheath tumor model. Exp Neurol. 2001 May; 169(1):64-71. PMID: 11312559.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  97. Wu A, Mazumder A, Martuza RL, Liu X, Thein M, Meehan KR, Rabkin SD. Biological purging of breast cancer cells using an attenuated replication-competent herpes simplex virus in human hematopoietic stem cell transplantation. Cancer Res. 2001 Apr 01; 61(7):3009-15. PMID: 11306480.
    Citations: 6     Fields:    Translation:HumansCells
  98. Toda M, Martuza RL, Rabkin SD. Combination suicide/cytokine gene therapy as adjuvants to a defective herpes simplex virus-based cancer vaccine. Gene Ther. 2001 Feb; 8(4):332-9. PMID: 11313808.
    Citations: 10     Fields:    Translation:AnimalsCells
  99. Mashour GA, Ratner N, Khan GA, Wang HL, Martuza RL, Kurtz A. The angiogenic factor midkine is aberrantly expressed in NF1-deficient Schwann cells and is a mitogen for neurofibroma-derived cells. Oncogene. 2001 Jan 04; 20(1):97-105. PMID: 11244508.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  100. Todo T, Martuza RL, Dallman MJ, Rabkin SD. In situ expression of soluble B7-1 in the context of oncolytic herpes simplex virus induces potent antitumor immunity. Cancer Res. 2001 Jan 01; 61(1):153-61. PMID: 11196154.
    Citations: 22     Fields:    Translation:AnimalsCells
  101. Todo T, Feigenbaum F, Rabkin SD, Lakeman F, Newsome JT, Johnson PA, Mitchell E, Belliveau D, Ostrove JM, Martuza RL. Viral shedding and biodistribution of G207, a multimutated, conditionally replicating herpes simplex virus type 1, after intracerebral inoculation in aotus. Mol Ther. 2000 Dec; 2(6):588-95. PMID: 11124059.
    Citations: 18     Fields:    Translation:AnimalsCells
  102. Toda M, Martuza RL, Rabkin SD. Tumor growth inhibition by intratumoral inoculation of defective herpes simplex virus vectors expressing granulocyte-macrophage colony-stimulating factor. Mol Ther. 2000 Oct; 2(4):324-9. PMID: 11020347.
    Citations: 19     Fields:    Translation:AnimalsCells
  103. Moulding HD, Martuza RL, Rabkin SD. Clinical mutations in the L1 neural cell adhesion molecule affect cell-surface expression. J Neurosci. 2000 Aug 01; 20(15):5696-702. PMID: 10908608.
    Citations: 8     Fields:    Translation:HumansCells
  104. Lim DJ, Rubenstein AE, Evans DG, Jacks T, Seizinger BG, Baser ME, Beebe D, Brackmann DE, Chiocca EA, Fehon RG, Giovannini M, Glazer R, Gusella JF, Gutmann DH, Korf B, Lieberman F, Martuza R, McClatchey AI, Parry DM, Pulst SM, Ramesh V, Ramsey WJ, Ratner N, Rutkowski JL, Ruttledge M, Weinstein DE. Advances in neurofibromatosis 2 (NF2): a workshop report. J Neurogenet. 2000 Jun; 14(2):63-106. PMID: 10992163.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  105. Todo T, Rabkin SD, Martuza RL. Evaluation of ganciclovir-mediated enhancement of the antitumoral effect in oncolytic, multimutated herpes simplex virus type 1 (G207) therapy of brain tumors. Cancer Gene Ther. 2000 Jun; 7(6):939-46. PMID: 10880026.
    Citations: 9     Fields:    Translation:AnimalsCells
  106. Markert JM, Medlock MD, Rabkin SD, Gillespie GY, Todo T, Hunter WD, Palmer CA, Feigenbaum F, Tornatore C, Tufaro F, Martuza RL. Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial. Gene Ther. 2000 May; 7(10):867-74. PMID: 10845725.
    Citations: 230     Fields:    Translation:HumansCellsCTClinical Trials
  107. Martuza RL. Conditionally replicating herpes vectors for cancer therapy. J Clin Invest. 2000 Apr; 105(7):841-6. PMID: 10749560.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  108. Sundaresan P, Hunter WD, Martuza RL, Rabkin SD. Attenuated, replication-competent herpes simplex virus type 1 mutant G207: safety evaluation in mice. J Virol. 2000 Apr; 74(8):3832-41. PMID: 10729157.
    Citations: 21     Fields:    Translation:AnimalsCells
  109. Sandhu FA, Schellinger D, Martuza RL. A vascular sarcoid mass mimicking a convexity meningioma. Neuroradiology. 2000 Mar; 42(3):195-8. PMID: 10772141.
    Citations: 2     Fields:    Translation:Humans
  110. Sandhu FA, Martuza RL. Craniofacial hemangiopericytoma associated with oncogenic osteomalacia: case report. J Neurooncol. 2000; 46(3):241-7. PMID: 10902855.
    Citations: 5     Fields:    Translation:Humans
  111. Mashour GA, Martuza RL, Kurtz A. Induction of melanogenic abnormalities in NF1+/- mutant mice by DMBA. J Invest Dermatol. 1999 Dec; 113(6):1133-4. PMID: 10594763.
    Citations:    Fields:    Translation:Animals
  112. Todo T, Rabkin SD, Sundaresan P, Wu A, Meehan KR, Herscowitz HB, Martuza RL. Systemic antitumor immunity in experimental brain tumor therapy using a multimutated, replication-competent herpes simplex virus. Hum Gene Ther. 1999 Nov 20; 10(17):2741-55. PMID: 10584921.
    Citations: 36     Fields:    Translation:AnimalsCells
  113. Todo T, Rabkin SD, Chahlavi A, Martuza RL. Corticosteroid administration does not affect viral oncolytic activity, but inhibits antitumor immunity in replication-competent herpes simplex virus tumor therapy. Hum Gene Ther. 1999 Nov 20; 10(17):2869-78. PMID: 10584932.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  114. Chahlavi A, Rabkin S, Todo T, Sundaresan P, Martuza R. Effect of prior exposure to herpes simplex virus 1 on viral vector-mediated tumor therapy in immunocompetent mice. Gene Ther. 1999 Oct; 6(10):1751-8. PMID: 10516725.
    Citations: 16     Fields:    Translation:AnimalsCellsPHPublic Health
  115. Mashour GA, Wang HL, Cabal-Manzano R, Wellstein A, Martuza RL, Kurtz A. Aberrant cutaneous expression of the angiogenic factor midkine is associated with neurofibromatosis type-1. J Invest Dermatol. 1999 Sep; 113(3):398-402. PMID: 10469340.
    Citations: 4     Fields:    Translation:HumansCells
  116. Walker JR, McGeagh KG, Sundaresan P, Jorgensen TJ, Rabkin SD, Martuza RL. Local and systemic therapy of human prostate adenocarcinoma with the conditionally replicating herpes simplex virus vector G207. Hum Gene Ther. 1999 Sep 01; 10(13):2237-43. PMID: 10498254.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  117. Hunter WD, Martuza RL, Feigenbaum F, Todo T, Mineta T, Yazaki T, Toda M, Newsome JT, Platenberg RC, Manz HJ, Rabkin SD. Attenuated, replication-competent herpes simplex virus type 1 mutant G207: safety evaluation of intracerebral injection in nonhuman primates. J Virol. 1999 Aug; 73(8):6319-26. PMID: 10400723.
    Citations: 43     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  118. Chahlavi A, Todo T, Martuza RL, Rabkin SD. Replication-competent herpes simplex virus vector G207 and cisplatin combination therapy for head and neck squamous cell carcinoma. Neoplasia. 1999 Jun; 1(2):162-9. PMID: 10933051.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  119. Miyatake SI, Tani S, Feigenbaum F, Sundaresan P, Toda H, Narumi O, Kikuchi H, Hashimoto N, Hangai M, Martuza RL, Rabkin SD. Hepatoma-specific antitumor activity of an albumin enhancer/promoter regulated herpes simplex virus in vivo. Gene Ther. 1999 Apr; 6(4):564-72. PMID: 10476216.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  120. Toda M, Rabkin SD, Kojima H, Martuza RL. Herpes simplex virus as an in situ cancer vaccine for the induction of specific anti-tumor immunity. Hum Gene Ther. 1999 Feb 10; 10(3):385-93. PMID: 10048391.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  121. New KC, Gale K, Martuza RL, Rabkin SD. Novel synthesis and release of GABA in cerebellar granule cell cultures after infection with defective herpes simplex virus vectors expressing glutamic acid decarboxylase. Brain Res Mol Brain Res. 1998 Oct 30; 61(1-2):121-35. PMID: 9795182.
    Citations: 1     Fields:    Translation:AnimalsCells
  122. Toda M, Rabkin SD, Martuza RL. Treatment of human breast cancer in a brain metastatic model by G207, a replication-competent multimutated herpes simplex virus 1. Hum Gene Ther. 1998 Oct 10; 9(15):2177-85. PMID: 9794202.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  123. Toda M, Martuza RL, Kojima H, Rabkin SD. In situ cancer vaccination: an IL-12 defective vector/replication-competent herpes simplex virus combination induces local and systemic antitumor activity. J Immunol. 1998 May 01; 160(9):4457-64. PMID: 9574551.
    Citations: 27     Fields:    Translation:AnimalsCellsPHPublic Health
  124. Martuza RL. Act locally, think globally. Nat Med. 1997 Dec; 3(12):1323. PMID: 9396599.
    Citations: 1     Fields:    Translation:HumansCells
  125. Miyatake S, Iyer A, Martuza RL, Rabkin SD. Transcriptional targeting of herpes simplex virus for cell-specific replication. J Virol. 1997 Jul; 71(7):5124-32. PMID: 9188579.
    Citations: 19     Fields:    Translation:HumansCells
  126. Miyatake S, Martuza RL, Rabkin SD. Defective herpes simplex virus vectors expressing thymidine kinase for the treatment of malignant glioma. Cancer Gene Ther. 1997 Jul-Aug; 4(4):222-8. PMID: 9253507.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  127. Menon AG, Rutter JL, von Sattel JP, Synder H, Murdoch C, Blumenfeld A, Martuza RL, von Deimling A, Gusella JF, Houseal TW. Frequent loss of chromosome 14 in atypical and malignant meningioma: identification of a putative 'tumor progression' locus. Oncogene. 1997 Feb 06; 14(5):611-6. PMID: 9053860.
    Citations: 15     Fields:    Translation:HumansCells
  128. Yazaki T, Martuza RL, Rabkin SD. Expression of L1 in primary astrocytes via a defective herpes simplex virus vector promotes neurite outgrowth and neural cell migration. Brain Res Mol Brain Res. 1996 Dec 31; 43(1-2):311-20. PMID: 9037547.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  129. Yazaki T, Ahmad S, Chahlavi A, Zylber-Katz E, Dean NM, Rabkin SD, Martuza RL, Glazer RI. Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C-alpha phosphorothioate oligodeoxynucleotide. Mol Pharmacol. 1996 Aug; 50(2):236-42. PMID: 8700129.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  130. Viola JJ, Martuza RL. Gene therapies for glioblastomas. Baillieres Clin Neurol. 1996 Jun; 5(2):413-24. PMID: 8781280.
    Citations: 1     Fields:    Translation:HumansCells
  131. Yazaki T, Manz HJ, Rabkin SD, Martuza RL. Treatment of human malignant meningiomas by G207, a replication-competent multimutated herpes simplex virus 1. Cancer Res. 1995 Nov 01; 55(21):4752-6. PMID: 7585498.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  132. Mineta T, Rabkin SD, Yazaki T, Hunter WD, Martuza RL. Attenuated multi-mutated herpes simplex virus-1 for the treatment of malignant gliomas. Nat Med. 1995 Sep; 1(9):938-43. PMID: 7585221.
    Citations: 169     Fields:    Translation:HumansAnimalsCells
  133. Baer L, Rauch SL, Ballantine HT, Martuza R, Cosgrove R, Cassem E, Giriunas I, Manzo PA, Dimino C, Jenike MA. Cingulotomy for intractable obsessive-compulsive disorder. Prospective long-term follow-up of 18 patients. Arch Gen Psychiatry. 1995 May; 52(5):384-92. PMID: 7726719.
    Citations: 12     Fields:    Translation:Humans
  134. Mineta T, Tabuchi K, Martuza RL. [Gene therapy for brain tumors: experimental treatment of malignant brain tumors using recombinant herpes simplex virus type 1 (series 7)]. No Shinkei Geka. 1995 Apr; 23(4):285-92. PMID: 7739766.
    Citations:    Fields:    Translation:AnimalsCells
  135. Yazaki T, Takamiya Y, Costello PC, Mineta T, Menon AG, Rabkin SD, Martuza RL. Inhibition of angiogenesis and growth of human non-malignant and malignant meningiomas by TNP-470. J Neurooncol. 1995; 23(1):23-9. PMID: 7542695.
    Citations: 7     Fields:    Translation:HumansAnimals
  136. al-Nabulsi I, Takamiya Y, Voloshin Y, Dritschilo A, Martuza RL, Jorgensen TJ. Expression of thymidine kinase is essential to low dose radiation resistance of rat glioma cells. Cancer Res. 1994 Nov 01; 54(21):5614-7. PMID: 7923206.
    Citations: 5     Fields:    Translation:AnimalsCells
  137. Ahmad S, Mineta T, Martuza RL, Glazer RI. Antisense expression of protein kinase C alpha inhibits the growth and tumorigenicity of human glioblastoma cells. Neurosurgery. 1994 Nov; 35(5):904-8; discussion 908-9. PMID: 7838340.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  138. Mineta T, Rabkin SD, Martuza RL. Treatment of malignant gliomas using ganciclovir-hypersensitive, ribonucleotide reductase-deficient herpes simplex viral mutant. Cancer Res. 1994 Aug 01; 54(15):3963-6. PMID: 8033122.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  139. Takamiya Y, Brem H, Ojeifo J, Mineta T, Martuza RL. AGM-1470 inhibits the growth of human glioblastoma cells in vitro and in vivo. Neurosurgery. 1994 May; 34(5):869-75; discussion 875. PMID: 8052385.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  140. New KC, Martuza RL, Rabkin SD. Defective herpes simplex virus vectors for the study of promoter and gene function in the CNS. Gene Ther. 1994; 1 Suppl 1:S79. PMID: 8542425.
    Citations:    Fields:    Translation:Cells
  141. Baer L, Rauch SL, Jenike MA, Cassem NH, Ballantine HT, Manzo PA, Martuza RL. Cingulotomy in a case of concomitant obsessive-compulsive disorder and Tourette's syndrome. Arch Gen Psychiatry. 1994 Jan; 51(1):73-4. PMID: 8279932.
    Citations: 2     Fields:    Translation:Humans
  142. Mineta T, Markert JM, Takamiya Y, Coen DM, Rabkin SD, Martuza RL. CNS tumor therapy by attenuated herpes simplex viruses. Gene Ther. 1994; 1 Suppl 1:S78. PMID: 8542424.
    Citations: 6     Fields:    Translation:AnimalsCells
  143. Yu JS, Wei MX, Chiocca EA, Martuza RL, Tepper RI. Treatment of glioma by engineered interleukin 4-secreting cells. Cancer Res. 1993 Jul 01; 53(13):3125-8. PMID: 8319220.
    Citations: 16     Fields:    Translation:HumansAnimals
  144. Takamiya Y, Short MP, Moolten FL, Fleet C, Mineta T, Breakefield XO, Martuza RL. An experimental model of retrovirus gene therapy for malignant brain tumors. J Neurosurg. 1993 Jul; 79(1):104-10. PMID: 8391069.
    Citations: 16     Fields:    Translation:AnimalsCells
  145. Markert JM, Malick A, Coen DM, Martuza RL. Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir. Neurosurgery. 1993 Apr; 32(4):597-603. PMID: 8386343.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  146. Takamiya Y, Friedlander RM, Brem H, Malick A, Martuza RL. Inhibition of angiogenesis and growth of human nerve-sheath tumors by AGM-1470. J Neurosurg. 1993 Mar; 78(3):470-6. PMID: 8433151.
    Citations: 15     Fields:    Translation:HumansAnimalsCTClinical Trials
  147. Takamiya Y, Short MP, Ezzeddine ZD, Moolten FL, Breakefield XO, Martuza RL. Gene therapy of malignant brain tumors: a rat glioma line bearing the herpes simplex virus type 1-thymidine kinase gene and wild type retrovirus kills other tumor cells. J Neurosci Res. 1992 Nov; 33(3):493-503. PMID: 1335091.
    Citations: 18     Fields:    Translation:AnimalsCells
  148. Nadol JB, Chiong CM, Ojemann RG, McKenna MJ, Martuza RL, Montgomery WW, Levine RA, Ronner SF, Glynn RJ. Preservation of hearing and facial nerve function in resection of acoustic neuroma. Laryngoscope. 1992 Oct; 102(10):1153-8. PMID: 1405966.
    Citations: 16     Fields:    Translation:Humans
  149. Markert JM, Coen DM, Malick A, Mineta T, Martuza RL. Expanded spectrum of viral therapy in the treatment of nervous system tumors. J Neurosurg. 1992 Oct; 77(4):590-4. PMID: 1326612.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  150. Lee JK, Sobel RA, Chiocca EA, Kim TS, Martuza RL. Growth of human acoustic neuromas, neurofibromas and schwannomas in the subrenal capsule and sciatic nerve of the nude mouse. J Neurooncol. 1992 Oct; 14(2):101-12. PMID: 1432035.
    Citations: 7     Fields:    Translation:HumansAnimals
  151. Narod SA, Parry DM, Parboosingh J, Lenoir GM, Ruttledge M, Fischer G, Eldridge R, Martuza RL, Frontali M, Haines J, et al. Neurofibromatosis type 2 appears to be a genetically homogeneous disease. Am J Hum Genet. 1992 Sep; 51(3):486-96. PMID: 1496982.
    Citations: 10     Fields:    Translation:HumansCells
  152. von Deimling A, Louis DN, von Ammon K, Petersen I, Hoell T, Chung RY, Martuza RL, Schoenfeld DA, Yasargil MG, Wiestler OD, et al. Association of epidermal growth factor receptor gene amplification with loss of chromosome 10 in human glioblastoma multiforme. J Neurosurg. 1992 Aug; 77(2):295-301. PMID: 1320666.
    Citations: 42     Fields:    Translation:HumansCells
  153. Poon WS, Schomacker KT, Deutsch TF, Martuza RL. Laser-induced fluorescence: experimental intraoperative delineation of tumor resection margins. J Neurosurg. 1992 Apr; 76(4):679-86. PMID: 1545262.
    Citations: 10     Fields:    Translation:Animals
  154. McKenna MJ, Halpin C, Ojemann RG, Nadol JB, Montgomery WW, Levine RA, Carlisle E, Martuza R. Long-term hearing results in patients after surgical removal of acoustic tumors with hearing preservation. Am J Otol. 1992 Mar; 13(2):134-6. PMID: 1599004.
    Citations: 6     Fields:    Translation:Humans
  155. Huang Q, Vonsattel JP, Schaffer PA, Martuza RL, Breakefield XO, DiFiglia M. Introduction of a foreign gene (Escherichia coli lacZ) into rat neostriatal neurons using herpes simplex virus mutants: a light and electron microscopic study. Exp Neurol. 1992 Mar; 115(3):303-16. PMID: 1311266.
    Citations: 9     Fields:    Translation:AnimalsCells
  156. Martuza RL. Molecular neurosurgery for glial and neuronal disorders. Stereotact Funct Neurosurg. 1992; 59(1-4):92-9. PMID: 1338233.
    Citations: 2     Fields:    Translation: