Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Edwin Kepner Silverman, Ph.D., M.D.

Co-Author

This page shows the publications co-authored by Edwin Silverman and Scott Weiss.
Connection Strength

6.468
  1. Pro: Genome-wide association studies (GWAS) in asthma. Am J Respir Crit Care Med. 2011 Sep 15; 184(6):631-3.
    View in: PubMed
    Score: 0.497
  2. Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program. J Allergy Clin Immunol. 2003 Nov; 112(5):870-6.
    View in: PubMed
    Score: 0.288
  3. Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet. 2002 May; 70(5):1229-39.
    View in: PubMed
    Score: 0.258
  4. Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes. Hum Mol Genet. 2002 Mar 15; 11(6):623-32.
    View in: PubMed
    Score: 0.257
  5. Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One. 2013; 8(2):e56179.
    View in: PubMed
    Score: 0.137
  6. Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet. 2012 Mar 15; 21(6):1325-35.
    View in: PubMed
    Score: 0.126
  7. Asthma-susceptibility variants identified using probands in case-control and family-based analyses. BMC Med Genet. 2010 Aug 10; 11:122.
    View in: PubMed
    Score: 0.115
  8. Stronger evidence for replication of NPPA using genome-wide genotyping data. Am J Respir Crit Care Med. 2010 Jan 01; 181(1):96.
    View in: PubMed
    Score: 0.110
  9. Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet. 2009 May; 84(5):581-93.
    View in: PubMed
    Score: 0.105
  10. Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. Am J Respir Crit Care Med. 2009 Jun 15; 179(12):1084-90.
    View in: PubMed
    Score: 0.104
  11. A common mitochondrial haplogroup is associated with elevated total serum IgE levels. J Allergy Clin Immunol. 2007 Aug; 120(2):351-8.
    View in: PubMed
    Score: 0.093
  12. Inflammatory markers of lung disease in adult patients with cystic fibrosis. Pediatr Pulmonol. 2007 Mar; 42(3):256-62.
    View in: PubMed
    Score: 0.091
  13. Significant linkage to airway responsiveness on chromosome 12q24 in families of children with asthma in Costa Rica. Hum Genet. 2007 Jan; 120(5):691-9.
    View in: PubMed
    Score: 0.088
  14. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):502.
    View in: PubMed
    Score: 0.087
  15. Eotaxin polymorphisms and serum total IgE levels in children with asthma. J Allergy Clin Immunol. 2006 Feb; 117(2):298-305.
    View in: PubMed
    Score: 0.084
  16. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet. 2006 Feb; 78(2):253-64.
    View in: PubMed
    Score: 0.083
  17. T-bet polymorphisms are associated with asthma and airway hyperresponsiveness. Am J Respir Crit Care Med. 2006 Jan 01; 173(1):64-70.
    View in: PubMed
    Score: 0.082
  18. Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes. Am J Respir Crit Care Med. 2005 Sep 15; 172(6):687-92.
    View in: PubMed
    Score: 0.081
  19. Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol. 2005 Jul; 33(1):71-8.
    View in: PubMed
    Score: 0.079
  20. Association of defensin beta-1 gene polymorphisms with asthma. J Allergy Clin Immunol. 2005 Feb; 115(2):252-8.
    View in: PubMed
    Score: 0.079
  21. Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004 Dec 15; 170(12):1294-301.
    View in: PubMed
    Score: 0.076
  22. The IL12B gene is associated with asthma. Am J Hum Genet. 2004 Oct; 75(4):709-15.
    View in: PubMed
    Score: 0.076
  23. Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma. Genes Immun. 2004 Aug; 5(5):343-6.
    View in: PubMed
    Score: 0.076
  24. Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med. 2004 Nov 15; 170(10):1057-65.
    View in: PubMed
    Score: 0.076
  25. Beta 2-adrenergic receptor polymorphisms and haplotypes are associated with airways hyperresponsiveness among nonsmoking men. Chest. 2004 Jul; 126(1):66-74.
    View in: PubMed
    Score: 0.075
  26. TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples. Am J Respir Crit Care Med. 2004 Sep 15; 170(6):594-600.
    View in: PubMed
    Score: 0.075
  27. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet. 2004 Aug 01; 13(15):1649-56.
    View in: PubMed
    Score: 0.075
  28. ADAM33 polymorphisms and phenotype associations in childhood asthma. J Allergy Clin Immunol. 2004 Jun; 113(6):1071-8.
    View in: PubMed
    Score: 0.075
  29. Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet. 2004 Jul 01; 13(13):1353-9.
    View in: PubMed
    Score: 0.075
  30. Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPD. Thorax. 2004 May; 59(5):396-400.
    View in: PubMed
    Score: 0.075
  31. IL10 gene polymorphisms are associated with asthma phenotypes in children. Genet Epidemiol. 2004 Feb; 26(2):155-65.
    View in: PubMed
    Score: 0.073
  32. Asthma steroid pharmacogenetics: a study strategy to identify replicated treatment responses. Proc Am Thorac Soc. 2004; 1(4):364-7.
    View in: PubMed
    Score: 0.073
  33. Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes. Hum Mol Genet. 2003 Aug 15; 12(16):1973-9.
    View in: PubMed
    Score: 0.071
  34. Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease. Hum Mol Genet. 2003 May 15; 12(10):1199-210.
    View in: PubMed
    Score: 0.070
  35. Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies. Genomics. 2003 Jan; 81(1):85-91.
    View in: PubMed
    Score: 0.068
  36. A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies. Hum Hered. 2003; 56(1-3):10-7.
    View in: PubMed
    Score: 0.068
  37. Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program. Genet Epidemiol. 2002 Nov; 23(4):335-48.
    View in: PubMed
    Score: 0.067
  38. Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. Am J Respir Crit Care Med. 2002 Dec 01; 166(11):1449-56.
    View in: PubMed
    Score: 0.067
  39. Single-nucleotide polymorphisms in the interleukin-10 gene: differences in frequencies, linkage disequilibrium patterns, and haplotypes in three United States ethnic groups. Genomics. 2002 Aug; 80(2):223-8.
    View in: PubMed
    Score: 0.066
  40. Lack of association between a polymorphism in the interleukin-13 gene and total serum immunoglobulin E level among nuclear families in Costa Rica. Clin Exp Allergy. 2002 Mar; 32(3):387-90.
    View in: PubMed
    Score: 0.064
  41. Multi-ethnic genome-wide and HLA association study of total serum IgE. J Allergy Clin Immunol. 2021 Sep 15.
    View in: PubMed
    Score: 0.062
  42. Risk factors for childhood asthma in Costa Rica. Chest. 2001 Sep; 120(3):785-90.
    View in: PubMed
    Score: 0.062
  43. Population sequencing data reveal a compendium of mutational processes in the human germ line. Science. 2021 08 27; 373(6558):1030-1035.
    View in: PubMed
    Score: 0.062
  44. Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain. Genet Epidemiol. 2021 10; 45(7):685-693.
    View in: PubMed
    Score: 0.061
  45. Author Correction: Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome. Nat Commun. 2021 Apr 19; 12(1):2434.
    View in: PubMed
    Score: 0.060
  46. Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2021 Mar; 591(7851):E27.
    View in: PubMed
    Score: 0.060
  47. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 2021 02; 590(7845):290-299.
    View in: PubMed
    Score: 0.060
  48. DNA methylation perturbations may link altered development and aging in the lung. Aging (Albany NY). 2021 01 19; 13(2):1742-1764.
    View in: PubMed
    Score: 0.059
  49. Linkage analysis of alpha 1-antitrypsin deficiency: lessons for complex diseases. Hum Hered. 2001; 52(4):223-32.
    View in: PubMed
    Score: 0.059
  50. Case-control association studies in pharmacogenetics. Pharmacogenomics J. 2001; 1(3):157-8.
    View in: PubMed
    Score: 0.059
  51. Gender-related differences in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000 Dec; 162(6):2152-8.
    View in: PubMed
    Score: 0.059
  52. Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD. Eur Respir J. 2020 10; 56(4).
    View in: PubMed
    Score: 0.058
  53. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2020 10; 586(7831):763-768.
    View in: PubMed
    Score: 0.058
  54. Sex-specific associations with DNA methylation in lung tissue demonstrate smoking interactions. Epigenetics. 2021 Jun; 16(6):692-703.
    View in: PubMed
    Score: 0.058
  55. locStra: Fast analysis of regional/global stratification in whole-genome sequencing studies. Genet Epidemiol. 2021 02; 45(1):82-98.
    View in: PubMed
    Score: 0.058
  56. Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts. Lancet Respir Med. 2020 07; 8(7):696-708.
    View in: PubMed
    Score: 0.057
  57. Unsupervised cluster analysis of SARS-CoV-2 genomes indicates that recent (June 2020) cases in Beijing are from a genetic subgroup that consists of mostly European and South(east) Asian samples, of which the latter are the most recent. bioRxiv. 2020 Jun 30.
    View in: PubMed
    Score: 0.057
  58. Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome. Nat Commun. 2020 02 10; 11(1):811.
    View in: PubMed
    Score: 0.056
  59. Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations. PLoS Genet. 2019 12; 15(12):e1008500.
    View in: PubMed
    Score: 0.055
  60. Bronchodilator responsiveness and serum total IgE levels in families of probands with severe early-onset COPD. Eur Respir J. 1999 Nov; 14(5):1009-14.
    View in: PubMed
    Score: 0.055
  61. Pharmacogenomics and Placebo Response in a Randomized Clinical Trial in Asthma. Clin Pharmacol Ther. 2019 12; 106(6):1261-1267.
    View in: PubMed
    Score: 0.055
  62. Microbiome-Transcriptome Interactions Related to Severity of Respiratory Syncytial Virus Infection. Sci Rep. 2019 09 25; 9(1):13824.
    View in: PubMed
    Score: 0.054
  63. Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes. NPJ Syst Biol Appl. 2018; 4:25.
    View in: PubMed
    Score: 0.050
  64. Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Am J Respir Crit Care Med. 1998 Jun; 157(6 Pt 1):1770-8.
    View in: PubMed
    Score: 0.049
  65. On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows. Genet Epidemiol. 2017 05; 41(4):332-340.
    View in: PubMed
    Score: 0.045
  66. Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. Am J Respir Cell Mol Biol. 2017 03; 56(3):332-341.
    View in: PubMed
    Score: 0.045
  67. Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. Am J Respir Crit Care Med. 2016 12 15; 194(12):1465-1474.
    View in: PubMed
    Score: 0.045
  68. Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med. 2016 May 12; 374(19):1842-1852.
    View in: PubMed
    Score: 0.043
  69. A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma. Hum Mol Genet. 2015 Jun 01; 24(11):3005-20.
    View in: PubMed
    Score: 0.039
  70. Association of SERPINE2 with asthma. Chest. 2011 Sep; 140(3):667-674.
    View in: PubMed
    Score: 0.030
  71. MMP12, lung function, and COPD in high-risk populations. N Engl J Med. 2009 Dec 31; 361(27):2599-608.
    View in: PubMed
    Score: 0.028
  72. Parsing the effects of individual SNPs in candidate genes with family data. Hum Hered. 2010; 69(2):91-103.
    View in: PubMed
    Score: 0.027
  73. On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies. PLoS Genet. 2009 Nov; 5(11):e1000741.
    View in: PubMed
    Score: 0.027
  74. A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet. 2009 Mar; 5(3):e1000429.
    View in: PubMed
    Score: 0.026
  75. On the replication of genetic associations: timing can be everything! Am J Hum Genet. 2008 Apr; 82(4):849-58.
    View in: PubMed
    Score: 0.024
  76. Testing and estimating gene-environment interactions in family-based association studies. Biometrics. 2008 Jun; 64(2):458-67.
    View in: PubMed
    Score: 0.024
  77. Modifying effects of the HFE polymorphisms on the association between lead burden and cognitive decline. Environ Health Perspect. 2007 Aug; 115(8):1210-5.
    View in: PubMed
    Score: 0.023
  78. The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet. 2007 Apr 27; 3(4):e61.
    View in: PubMed
    Score: 0.023
  79. A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2005 Oct; 33(4):355-62.
    View in: PubMed
    Score: 0.020
  80. Genomic screening and replication using the same data set in family-based association testing. Nat Genet. 2005 Jul; 37(7):683-91.
    View in: PubMed
    Score: 0.020
  81. CD14 tobacco gene-environment interaction modifies asthma severity and immunoglobulin E levels in Latinos with asthma. Am J Respir Crit Care Med. 2005 Jul 15; 172(2):173-82.
    View in: PubMed
    Score: 0.020
  82. Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med. 2005 Mar 15; 171(6):563-70.
    View in: PubMed
    Score: 0.019
  83. A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol. 2004; 3:Article17.
    View in: PubMed
    Score: 0.019
  84. Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study. Environ Health Perspect. 2004 May; 112(6):746-50.
    View in: PubMed
    Score: 0.019
  85. PBAT: tools for family-based association studies. Am J Hum Genet. 2004 Feb; 74(2):367-9.
    View in: PubMed
    Score: 0.018
  86. Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol. 2004 Jan; 26(1):61-9.
    View in: PubMed
    Score: 0.018
  87. Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med. 2004 Feb 01; 169(3):386-92.
    View in: PubMed
    Score: 0.018
  88. Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet. 2003 Oct; 73(4):801-11.
    View in: PubMed
    Score: 0.018
  89. ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med. 2003 Dec 01; 168(11):1312-6.
    View in: PubMed
    Score: 0.018
  90. Apolipoprotein E genotype predicts 24-month bayley scales infant development score. Pediatr Res. 2003 Dec; 54(6):819-25.
    View in: PubMed
    Score: 0.018
  91. A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics. 2003 Apr; 4(2):195-206.
    View in: PubMed
    Score: 0.017
  92. Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous. Hum Hered. 2003; 55(1):56-65.
    View in: PubMed
    Score: 0.017
  93. Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease. Immunol Rev. 2002 Dec; 190:9-25.
    View in: PubMed
    Score: 0.017
  94. Maternal history, sensitization to allergens, and current wheezing, rhinitis, and eczema among children in Costa Rica. Pediatr Pulmonol. 2002 Apr; 33(4):237-43.
    View in: PubMed
    Score: 0.016
  95. Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma. Int Arch Allergy Immunol. 2001 Jan-Mar; 124(1-3):183-6.
    View in: PubMed
    Score: 0.015
  96. Application of an algorithm for the diagnosis of asthma in Chinese families: limitations and alternatives for the phenotypic assessment of asthma in family-based genetic studies. Am J Respir Crit Care Med. 2000 Nov; 162(5):1679-84.
    View in: PubMed
    Score: 0.015
  97. The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med. 2000 Jul; 162(1):75-80.
    View in: PubMed
    Score: 0.014
  98. Association between a sequence variant in the IL-4 gene promoter and FEV(1) in asthma. Am J Respir Crit Care Med. 1999 Sep; 160(3):919-22.
    View in: PubMed
    Score: 0.013
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.