Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Edwin Kepner Silverman, Ph.D., M.D.

Co-Author

This page shows the publications co-authored by Edwin Silverman and Peter Castaldi.
Connection Strength

7.400
  1. Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies. Thorax. 2011 Oct; 66(10):903-9.
    View in: PubMed
    Score: 0.479
  2. Development of predictive models for airflow obstruction in alpha-1-antitrypsin deficiency. Am J Epidemiol. 2009 Oct 15; 170(8):1005-13.
    View in: PubMed
    Score: 0.438
  3. Genetic associations with hypoxemia and pulmonary arterial pressure in COPD. Chest. 2009 Mar; 135(3):737-744.
    View in: PubMed
    Score: 0.415
  4. Characterization of a COPD-Associated NPNT Functional Splicing Genetic Variant in Human Lung Tissue via Long-Read Sequencing. medRxiv. 2020 Nov 03.
    View in: PubMed
    Score: 0.238
  5. Machine Learning Characterization of COPD Subtypes: Insights From the COPDGene Study. Chest. 2020 05; 157(5):1147-1157.
    View in: PubMed
    Score: 0.224
  6. Correction to: RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking. BMC Med Genomics. 2019 11 18; 12(1):166.
    View in: PubMed
    Score: 0.222
  7. Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Crit Care Med. 2019 09 15; 200(6):677-690.
    View in: PubMed
    Score: 0.220
  8. Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts. Elife. 2019 07 25; 8.
    View in: PubMed
    Score: 0.218
  9. Turning subtypes into disease axes to improve prediction of COPD progression. Thorax. 2019 09; 74(9):906-909.
    View in: PubMed
    Score: 0.216
  10. Identification of Functional Variants in the FAM13A Chronic Obstructive Pulmonary Disease Genome-Wide Association Study Locus by Massively Parallel Reporter Assays. Am J Respir Crit Care Med. 2019 01 01; 199(1):52-61.
    View in: PubMed
    Score: 0.209
  11. Systemic Markers of Adaptive and Innate Immunity Are Associated with Chronic Obstructive Pulmonary Disease Severity and Spirometric Disease Progression. Am J Respir Cell Mol Biol. 2018 04; 58(4):500-509.
    View in: PubMed
    Score: 0.199
  12. RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking. BMC Med Genomics. 2017 10 06; 10(1):58.
    View in: PubMed
    Score: 0.192
  13. Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts. Thorax. 2017 11; 72(11):998-1006.
    View in: PubMed
    Score: 0.188
  14. Screening for interaction effects in gene expression data. PLoS One. 2017; 12(3):e0173847.
    View in: PubMed
    Score: 0.185
  15. Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. J Cachexia Sarcopenia Muscle. 2017 Jun; 8(3):428-436.
    View in: PubMed
    Score: 0.182
  16. Visual Assessment of Chest Computed Tomographic Images Is Independently Useful for Genetic Association Analysis in Studies of Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2017 Jan; 14(1):33-40.
    View in: PubMed
    Score: 0.182
  17. COPD subtypes identified by network-based clustering of blood gene expression. Genomics. 2016 Mar; 107(2-3):51-58.
    View in: PubMed
    Score: 0.170
  18. Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci. Hum Mol Genet. 2015 Feb 15; 24(4):1200-10.
    View in: PubMed
    Score: 0.156
  19. Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. Am J Respir Crit Care Med. 2014 Aug 15; 190(4):399-409.
    View in: PubMed
    Score: 0.154
  20. Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD. BMC Syst Biol. 2014 Jun 25; 8:78.
    View in: PubMed
    Score: 0.153
  21. Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema. Thorax. 2014 May; 69(5):415-22.
    View in: PubMed
    Score: 0.149
  22. Distinct quantitative computed tomography emphysema patterns are associated with physiology and function in smokers. Am J Respir Crit Care Med. 2013 Nov 01; 188(9):1083-90.
    View in: PubMed
    Score: 0.146
  23. CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland. Am J Respir Cell Mol Biol. 2012 Aug; 47(2):203-8.
    View in: PubMed
    Score: 0.131
  24. The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. Am J Respir Cell Mol Biol. 2011 Dec; 45(6):1147-53.
    View in: PubMed
    Score: 0.124
  25. The COPD genetic association compendium: a comprehensive online database of COPD genetic associations. Hum Mol Genet. 2010 Feb 01; 19(3):526-34.
    View in: PubMed
    Score: 0.111
  26. Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD. Respir Res. 2021 Apr 27; 22(1):127.
    View in: PubMed
    Score: 0.061
  27. Statistical considerations for the analysis of massively parallel reporter assays data. Genet Epidemiol. 2020 10; 44(7):785-794.
    View in: PubMed
    Score: 0.058
  28. Heme metabolism genes Downregulated in COPD Cachexia. Respir Res. 2020 May 01; 21(1):100.
    View in: PubMed
    Score: 0.057
  29. Machine Learning and Prediction of All-Cause Mortality in COPD. Chest. 2020 09; 158(3):952-964.
    View in: PubMed
    Score: 0.057
  30. Integrated transcriptomic correlation network analysis identifies COPD molecular determinants. Sci Rep. 2020 02 25; 10(1):3361.
    View in: PubMed
    Score: 0.057
  31. COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2019 Nov; 6(5):384-399.
    View in: PubMed
    Score: 0.055
  32. Subtypes of COPD Have Unique Distributions and Differential Risk of Mortality. Chronic Obstr Pulm Dis. 2019 Nov; 6(5):400-413.
    View in: PubMed
    Score: 0.055
  33. Peripheral Blood Gene Expression Signatures of Eosinophilic Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2019 09; 61(3):398-401.
    View in: PubMed
    Score: 0.055
  34. Omics and the Search for Blood Biomarkers in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Cell Mol Biol. 2019 08; 61(2):143-149.
    View in: PubMed
    Score: 0.054
  35. Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene. PLoS Genet. 2019 07; 15(7):e1008229.
    View in: PubMed
    Score: 0.054
  36. RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD. Respir Res. 2019 Apr 02; 20(1):65.
    View in: PubMed
    Score: 0.053
  37. Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution. Am J Respir Cell Mol Biol. 2019 04; 60(4):388-398.
    View in: PubMed
    Score: 0.053
  38. Assessing pleiotropy and mediation in genetic loci associated with chronic obstructive pulmonary disease. Genet Epidemiol. 2019 04; 43(3):318-329.
    View in: PubMed
    Score: 0.053
  39. Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene. JCI Insight. 2018 11 15; 3(22).
    View in: PubMed
    Score: 0.052
  40. Genomics and response to long-term oxygen therapy in chronic obstructive pulmonary disease. J Mol Med (Berl). 2018 12; 96(12):1375-1385.
    View in: PubMed
    Score: 0.052
  41. Longitudinal Modeling of Lung Function Trajectories in Smokers with and without Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018 10 15; 198(8):1033-1042.
    View in: PubMed
    Score: 0.052
  42. Identification of Chronic Obstructive Pulmonary Disease Axes That Predict All-Cause Mortality: The COPDGene Study. Am J Epidemiol. 2018 10 01; 187(10):2109-2116.
    View in: PubMed
    Score: 0.051
  43. Integrative epigenomic analysis in differentiated human primary bronchial epithelial cells exposed to cigarette smoke. Sci Rep. 2018 08 24; 8(1):12750.
    View in: PubMed
    Score: 0.051
  44. Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2018 06; 141(6):2037-2047.e10.
    View in: PubMed
    Score: 0.050
  45. Integrative genomics identifies new genes associated with severe COPD and emphysema. Respir Res. 2018 03 22; 19(1):46.
    View in: PubMed
    Score: 0.050
  46. The value of blood cytokines and chemokines in assessing COPD. Respir Res. 2017 10 24; 18(1):180.
    View in: PubMed
    Score: 0.048
  47. Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression. Chest. 2018 01; 153(1):65-76.
    View in: PubMed
    Score: 0.048
  48. Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects. Am J Respir Cell Mol Biol. 2017 07; 57(1):35-46.
    View in: PubMed
    Score: 0.047
  49. Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Am J Respir Crit Care Med. 2017 03 15; 195(6):757-771.
    View in: PubMed
    Score: 0.046
  50. Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. Am J Respir Cell Mol Biol. 2017 03; 56(3):332-341.
    View in: PubMed
    Score: 0.046
  51. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet. 2017 Mar; 49(3):426-432.
    View in: PubMed
    Score: 0.046
  52. A Bayesian Nonparametric Model for Disease Subtyping: Application to Emphysema Phenotypes. IEEE Trans Med Imaging. 2017 01; 36(1):343-354.
    View in: PubMed
    Score: 0.046
  53. Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. Am J Respir Crit Care Med. 2016 12 15; 194(12):1465-1474.
    View in: PubMed
    Score: 0.045
  54. A Bayesian Nonparametric Model for Disease Subtyping: Application to Emphysema Phenotypes. IEEE Trans Med Imaging. 2016 Sep 13.
    View in: PubMed
    Score: 0.045
  55. Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. PLoS Genet. 2016 Aug; 12(8):e1006011.
    View in: PubMed
    Score: 0.044
  56. A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of ß-Catenin. Am J Respir Crit Care Med. 2016 07 15; 194(2):185-97.
    View in: PubMed
    Score: 0.044
  57. Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 07 01; 194(1):48-57.
    View in: PubMed
    Score: 0.044
  58. Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med. 2016 May 12; 374(19):1842-1852.
    View in: PubMed
    Score: 0.044
  59. A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet. 2015 Dec 03; 16:138.
    View in: PubMed
    Score: 0.042
  60. A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. Am J Respir Crit Care Med. 2015 Sep 01; 192(5):559-69.
    View in: PubMed
    Score: 0.042
  61. Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2014 Nov; 11(9):1387-94.
    View in: PubMed
    Score: 0.039
  62. Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2014 Nov; 51(5):678-87.
    View in: PubMed
    Score: 0.039
  63. Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. BMC Pulm Med. 2014 Oct 24; 14:164.
    View in: PubMed
    Score: 0.039
  64. DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease. Respir Res. 2014 Aug 20; 15:97.
    View in: PubMed
    Score: 0.039
  65. Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. Respir Med. 2014 Oct; 108(10):1469-80.
    View in: PubMed
    Score: 0.039
  66. Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. Respir Res. 2014 Aug 06; 15:89.
    View in: PubMed
    Score: 0.039
  67. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med. 2014 Mar; 2(3):214-25.
    View in: PubMed
    Score: 0.037
  68. Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. Am J Respir Crit Care Med. 2013 Oct 15; 188(8):941-7.
    View in: PubMed
    Score: 0.036
  69. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet. 2012 Feb 15; 21(4):947-57.
    View in: PubMed
    Score: 0.032
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.