Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Edwin Kepner Silverman, Ph.D., M.D.

Co-Author

This page shows the publications co-authored by Edwin Silverman and Peter Castaldi.
Connection Strength

7.692
  1. Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies. Thorax. 2011 Oct; 66(10):903-9.
    View in: PubMed
    Score: 0.455
  2. Development of predictive models for airflow obstruction in alpha-1-antitrypsin deficiency. Am J Epidemiol. 2009 Oct 15; 170(8):1005-13.
    View in: PubMed
    Score: 0.416
  3. Genetic associations with hypoxemia and pulmonary arterial pressure in COPD. Chest. 2009 Mar; 135(3):737-744.
    View in: PubMed
    Score: 0.394
  4. Lung proteomic biomarkers associated with chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2021 12 01; 321(6):L1119-L1130.
    View in: PubMed
    Score: 0.241
  5. Improved prediction of smoking status via isoform-aware RNA-seq deep learning models. PLoS Comput Biol. 2021 10; 17(10):e1009433.
    View in: PubMed
    Score: 0.241
  6. Characterization of a COPD-Associated NPNT Functional Splicing Genetic Variant in Human Lung Tissue via Long-Read Sequencing. medRxiv. 2020 Nov 03.
    View in: PubMed
    Score: 0.226
  7. Machine Learning Characterization of COPD Subtypes: Insights From the COPDGene Study. Chest. 2020 05; 157(5):1147-1157.
    View in: PubMed
    Score: 0.213
  8. Correction to: RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking. BMC Med Genomics. 2019 11 18; 12(1):166.
    View in: PubMed
    Score: 0.211
  9. Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Crit Care Med. 2019 09 15; 200(6):677-690.
    View in: PubMed
    Score: 0.209
  10. Identification of an emphysema-associated genetic variant near TGFB2 with regulatory effects in lung fibroblasts. Elife. 2019 07 25; 8.
    View in: PubMed
    Score: 0.207
  11. Turning subtypes into disease axes to improve prediction of COPD progression. Thorax. 2019 09; 74(9):906-909.
    View in: PubMed
    Score: 0.205
  12. Identification of Functional Variants in the FAM13A Chronic Obstructive Pulmonary Disease Genome-Wide Association Study Locus by Massively Parallel Reporter Assays. Am J Respir Crit Care Med. 2019 01 01; 199(1):52-61.
    View in: PubMed
    Score: 0.199
  13. Systemic Markers of Adaptive and Innate Immunity Are Associated with Chronic Obstructive Pulmonary Disease Severity and Spirometric Disease Progression. Am J Respir Cell Mol Biol. 2018 04; 58(4):500-509.
    View in: PubMed
    Score: 0.189
  14. RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking. BMC Med Genomics. 2017 10 06; 10(1):58.
    View in: PubMed
    Score: 0.182
  15. Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts. Thorax. 2017 11; 72(11):998-1006.
    View in: PubMed
    Score: 0.179
  16. Screening for interaction effects in gene expression data. PLoS One. 2017; 12(3):e0173847.
    View in: PubMed
    Score: 0.175
  17. Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1. J Cachexia Sarcopenia Muscle. 2017 Jun; 8(3):428-436.
    View in: PubMed
    Score: 0.173
  18. Visual Assessment of Chest Computed Tomographic Images Is Independently Useful for Genetic Association Analysis in Studies of Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2017 Jan; 14(1):33-40.
    View in: PubMed
    Score: 0.173
  19. COPD subtypes identified by network-based clustering of blood gene expression. Genomics. 2016 Mar; 107(2-3):51-58.
    View in: PubMed
    Score: 0.162
  20. Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci. Hum Mol Genet. 2015 Feb 15; 24(4):1200-10.
    View in: PubMed
    Score: 0.148
  21. Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. Am J Respir Crit Care Med. 2014 Aug 15; 190(4):399-409.
    View in: PubMed
    Score: 0.147
  22. Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD. BMC Syst Biol. 2014 Jun 25; 8:78.
    View in: PubMed
    Score: 0.145
  23. Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema. Thorax. 2014 May; 69(5):415-22.
    View in: PubMed
    Score: 0.142
  24. Distinct quantitative computed tomography emphysema patterns are associated with physiology and function in smokers. Am J Respir Crit Care Med. 2013 Nov 01; 188(9):1083-90.
    View in: PubMed
    Score: 0.139
  25. CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland. Am J Respir Cell Mol Biol. 2012 Aug; 47(2):203-8.
    View in: PubMed
    Score: 0.124
  26. The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. Am J Respir Cell Mol Biol. 2011 Dec; 45(6):1147-53.
    View in: PubMed
    Score: 0.118
  27. The COPD genetic association compendium: a comprehensive online database of COPD genetic associations. Hum Mol Genet. 2010 Feb 01; 19(3):526-34.
    View in: PubMed
    Score: 0.106
  28. Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2022 02 01; 205(3):313-323.
    View in: PubMed
    Score: 0.062
  29. Development of a Blood-based Transcriptional Risk Score for Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2022 01 15; 205(2):161-170.
    View in: PubMed
    Score: 0.061
  30. Alternative poly-adenylation modulates a1-antitrypsin expression in chronic obstructive pulmonary disease. PLoS Genet. 2021 11; 17(11):e1009912.
    View in: PubMed
    Score: 0.061
  31. Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD. Respir Res. 2021 Apr 27; 22(1):127.
    View in: PubMed
    Score: 0.058
  32. Statistical considerations for the analysis of massively parallel reporter assays data. Genet Epidemiol. 2020 10; 44(7):785-794.
    View in: PubMed
    Score: 0.055
  33. Heme metabolism genes Downregulated in COPD Cachexia. Respir Res. 2020 May 01; 21(1):100.
    View in: PubMed
    Score: 0.054
  34. Machine Learning and Prediction of All-Cause Mortality in COPD. Chest. 2020 09; 158(3):952-964.
    View in: PubMed
    Score: 0.054
  35. Integrated transcriptomic correlation network analysis identifies COPD molecular determinants. Sci Rep. 2020 02 25; 10(1):3361.
    View in: PubMed
    Score: 0.054
  36. COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2019 Nov; 6(5):384-399.
    View in: PubMed
    Score: 0.053
  37. Subtypes of COPD Have Unique Distributions and Differential Risk of Mortality. Chronic Obstr Pulm Dis. 2019 Nov; 6(5):400-413.
    View in: PubMed
    Score: 0.053
  38. Peripheral Blood Gene Expression Signatures of Eosinophilic Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2019 09; 61(3):398-401.
    View in: PubMed
    Score: 0.052
  39. Omics and the Search for Blood Biomarkers in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Cell Mol Biol. 2019 08; 61(2):143-149.
    View in: PubMed
    Score: 0.052
  40. Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene. PLoS Genet. 2019 07; 15(7):e1008229.
    View in: PubMed
    Score: 0.051
  41. RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD. Respir Res. 2019 Apr 02; 20(1):65.
    View in: PubMed
    Score: 0.051
  42. Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution. Am J Respir Cell Mol Biol. 2019 04; 60(4):388-398.
    View in: PubMed
    Score: 0.051
  43. Assessing pleiotropy and mediation in genetic loci associated with chronic obstructive pulmonary disease. Genet Epidemiol. 2019 04; 43(3):318-329.
    View in: PubMed
    Score: 0.050
  44. Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene. JCI Insight. 2018 11 15; 3(22).
    View in: PubMed
    Score: 0.049
  45. Genomics and response to long-term oxygen therapy in chronic obstructive pulmonary disease. J Mol Med (Berl). 2018 12; 96(12):1375-1385.
    View in: PubMed
    Score: 0.049
  46. Longitudinal Modeling of Lung Function Trajectories in Smokers with and without Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018 10 15; 198(8):1033-1042.
    View in: PubMed
    Score: 0.049
  47. Identification of Chronic Obstructive Pulmonary Disease Axes That Predict All-Cause Mortality: The COPDGene Study. Am J Epidemiol. 2018 10 01; 187(10):2109-2116.
    View in: PubMed
    Score: 0.049
  48. Integrative epigenomic analysis in differentiated human primary bronchial epithelial cells exposed to cigarette smoke. Sci Rep. 2018 08 24; 8(1):12750.
    View in: PubMed
    Score: 0.048
  49. Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2018 06; 141(6):2037-2047.e10.
    View in: PubMed
    Score: 0.047
  50. Integrative genomics identifies new genes associated with severe COPD and emphysema. Respir Res. 2018 03 22; 19(1):46.
    View in: PubMed
    Score: 0.047
  51. The value of blood cytokines and chemokines in assessing COPD. Respir Res. 2017 10 24; 18(1):180.
    View in: PubMed
    Score: 0.046
  52. Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression. Chest. 2018 01; 153(1):65-76.
    View in: PubMed
    Score: 0.045
  53. Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects. Am J Respir Cell Mol Biol. 2017 07; 57(1):35-46.
    View in: PubMed
    Score: 0.045
  54. Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Am J Respir Crit Care Med. 2017 03 15; 195(6):757-771.
    View in: PubMed
    Score: 0.044
  55. Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. Am J Respir Cell Mol Biol. 2017 03; 56(3):332-341.
    View in: PubMed
    Score: 0.044
  56. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet. 2017 Mar; 49(3):426-432.
    View in: PubMed
    Score: 0.044
  57. A Bayesian Nonparametric Model for Disease Subtyping: Application to Emphysema Phenotypes. IEEE Trans Med Imaging. 2017 01; 36(1):343-354.
    View in: PubMed
    Score: 0.043
  58. Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. Am J Respir Crit Care Med. 2016 12 15; 194(12):1465-1474.
    View in: PubMed
    Score: 0.043
  59. A Bayesian Nonparametric Model for Disease Subtyping: Application to Emphysema Phenotypes. IEEE Trans Med Imaging. 2016 Sep 13.
    View in: PubMed
    Score: 0.042
  60. Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. PLoS Genet. 2016 Aug; 12(8):e1006011.
    View in: PubMed
    Score: 0.042
  61. A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of ß-Catenin. Am J Respir Crit Care Med. 2016 07 15; 194(2):185-97.
    View in: PubMed
    Score: 0.042
  62. Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 07 01; 194(1):48-57.
    View in: PubMed
    Score: 0.042
  63. Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma. N Engl J Med. 2016 May 12; 374(19):1842-1852.
    View in: PubMed
    Score: 0.041
  64. A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet. 2015 Dec 03; 16:138.
    View in: PubMed
    Score: 0.040
  65. A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. Am J Respir Crit Care Med. 2015 Sep 01; 192(5):559-69.
    View in: PubMed
    Score: 0.039
  66. Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2014 Nov; 11(9):1387-94.
    View in: PubMed
    Score: 0.037
  67. Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2014 Nov; 51(5):678-87.
    View in: PubMed
    Score: 0.037
  68. Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. BMC Pulm Med. 2014 Oct 24; 14:164.
    View in: PubMed
    Score: 0.037
  69. DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease. Respir Res. 2014 Aug 20; 15:97.
    View in: PubMed
    Score: 0.037
  70. Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. Respir Med. 2014 Oct; 108(10):1469-80.
    View in: PubMed
    Score: 0.037
  71. Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. Respir Res. 2014 Aug 06; 15:89.
    View in: PubMed
    Score: 0.037
  72. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med. 2014 Mar; 2(3):214-25.
    View in: PubMed
    Score: 0.035
  73. Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. Am J Respir Crit Care Med. 2013 Oct 15; 188(8):941-7.
    View in: PubMed
    Score: 0.035
  74. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet. 2012 Feb 15; 21(4):947-57.
    View in: PubMed
    Score: 0.030
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.