Harvard Catalyst Profiles

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Chandan Sharma, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sharma C, Hemler ME. Antioxidant and Anticancer Functions of Protein Acyltransferase DHHC3. Antioxidants (Basel). 2022 May 12; 11(5). PMID: 35624824; PMCID: PMC9137668.
  2. Sharma C, Yang W, Steen H, Freeman MR, Hemler ME. Antioxidant functions of DHHC3 suppress anti-cancer drug activities. Cell Mol Life Sci. 2021 Mar; 78(5):2341-2353. PMID: 32986127; PMCID: PMC8751980.
    Citations: 4     Fields:    Translation:HumansCells
  3. Sharma C, Hemler ME. Multiple pro-tumor roles for protein acyltransferase DHHC3. Oncoscience. 2017 Nov; 4(11-12):152-153. PMID: 29344544; PMCID: PMC5769970.
  4. Sharma C, Wang HX, Li Q, Knoblich K, Reisenbichler ES, Richardson AL, Hemler ME. Protein Acyltransferase DHHC3 Regulates Breast Tumor Growth, Oxidative Stress, and Senescence. Cancer Res. 2017 12 15; 77(24):6880-6890. PMID: 29055014; PMCID: PMC5819883.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  5. Wang HX, Sharma C, Knoblich K, Granter SR, Hemler ME. EWI-2 negatively regulates TGF-ß signaling leading to altered melanoma growth and metastasis. Cell Res. 2015 Mar; 25(3):370-85. PMID: 25656846; PMCID: PMC4349253.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  6. Knoblich K, Wang HX, Sharma C, Fletcher AL, Turley SJ, Hemler ME. Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits ß-catenin degradation. Cell Mol Life Sci. 2014 Apr; 71(7):1305-14. PMID: 23955570.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  7. Deng X, Li Q, Hoff J, Novak M, Yang H, Jin H, Erfani SF, Sharma C, Zhou P, Rabinovitz I, Sonnenberg A, Yi Y, Zhou P, Stipp CS, Kaetzel DM, Hemler ME, Yang XH. Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis. Neoplasia. 2012 Aug; 14(8):678-89. PMID: 22952421.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  8. Sharma C, Rabinovitz I, Hemler ME. Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin a6ß4. Cell Mol Life Sci. 2012 Jul; 69(13):2233-44. PMID: 22314500.
    Citations: 27     Fields:    Translation:HumansCells
  9. Wang HX, Li Q, Sharma C, Knoblich K, Hemler ME. Tetraspanin protein contributions to cancer. Biochem Soc Trans. 2011 Apr; 39(2):547-52. PMID: 21428937.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  10. Xu D, Sharma C, Hemler ME. Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein. FASEB J. 2009 Nov; 23(11):3674-81. PMID: 19587294.
    Citations: 59     Fields:    Translation:HumansCells
  11. Fiorentino M, Zadra G, Palescandolo E, Fedele G, Bailey D, Fiore C, Nguyen PL, Migita T, Zamponi R, Di Vizio D, Priolo C, Sharma C, Xie W, Hemler ME, Mucci L, Giovannucci E, Finn S, Loda M. Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer. Lab Invest. 2008 Dec; 88(12):1340-8. PMID: 18838960; PMCID: PMC3223737.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  12. Sharma C, Yang XH, Hemler ME. DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151. Mol Biol Cell. 2008 Aug; 19(8):3415-25. PMID: 18508921.
    Citations: 46     Fields:    Translation:HumansCells
  13. Yang XH, Richardson AL, Torres-Arzayus MI, Zhou P, Sharma C, Kazarov AR, Andzelm MM, Strominger JL, Brown M, Hemler ME. CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization. Cancer Res. 2008 May 01; 68(9):3204-13. PMID: 18451146.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  14. Sharma C, Pradeep A, Wong L, Rana A, Rana B. Peroxisome proliferator-activated receptor gamma activation can regulate beta-catenin levels via a proteasome-mediated and adenomatous polyposis coli-independent pathway. J Biol Chem. 2004 Aug 20; 279(34):35583-94. PMID: 15190077.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  15. Pradeep A, Sharma C, Sathyanarayana P, Albanese C, Fleming JV, Wang TC, Wolfe MM, Baker KM, Pestell RG, Rana B. Gastrin-mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells. Oncogene. 2004 Apr 29; 23(20):3689-99. PMID: 15116100.
    Citations: 42     Fields:    Translation:HumansCells
  16. Sharma C, Pradeep A, Pestell RG, Rana B. Peroxisome proliferator-activated receptor gamma activation modulates cyclin D1 transcription via beta-catenin-independent and cAMP-response element-binding protein-dependent pathways in mouse hepatocytes. J Biol Chem. 2004 Apr 23; 279(17):16927-38. PMID: 14764597.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  17. Barthwal MK, Sathyanarayana P, Kundu CN, Rana B, Pradeep A, Sharma C, Woodgett JR, Rana A. Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. J Biol Chem. 2003 Feb 07; 278(6):3897-902. PMID: 12458207.
    Citations: 48     Fields:    Translation:HumansCells
  18. Farokhzad OC, Sagar GD, Mun EC, Sicklick JK, Lotz M, Smith JA, Song JC, O'Brien TC, Sharma CP, Kinane TB, Hodin RA, Matthews JB. Protein kinase C activation downregulates the expression and function of the basolateral Na+/K+/2Cl(-) cotransporter. J Cell Physiol. 1999 Dec; 181(3):489-98. PMID: 10528235.
    Citations: 7     Fields:    Translation:HumansCells
  19. Goldmann WH, Teodoridis JM, Sharma CP, Alonso JL, Isenberg G. Fragments from alpha-actinin insert into reconstituted lipid bilayers. Biochem Biophys Res Commun. 1999 Oct 14; 264(1):225-9. PMID: 10527869.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Goldmann WH, Teodoridis JM, Sharma CP, Hu B, Isenberg G. Fragments from actin binding protein (ABP-280; filamin) insert into reconstituted lipid layers. Biochem Biophys Res Commun. 1999 May 27; 259(1):108-12. PMID: 10334924.
    Citations: 2     Fields:    Translation:HumansCells
  21. Singh M, Sharma C. Detection of plasmid-encoded gusA gene in GUS-positive Escherichia coli. Biotechniques. 1999 Feb; 26(2):261-4. PMID: 10023538.
    Citations:    Fields:    Translation:Cells
  22. Kanazashi SI, Sharma CP, Arnaout MA. Integrin-ligand interactions: scratching the surface. Curr Opin Hematol. 1997 Jan; 4(1):67-74. PMID: 9050382.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  23. Palsson R, Sharma CP, Kim K, McLaughlin M, Brown D, Arnaout MA. Characterization and cell distribution of polycystin, the product of autosomal dominant polycystic kidney disease gene 1. Mol Med. 1996 Nov; 2(6):702-11. PMID: 8972485; PMCID: PMC2230129.
    Citations: 21     Fields:    Translation:HumansAnimals
  24. Sharma CP, Ezzell RM, Arnaout MA. Direct interaction of filamin (ABP-280) with the beta 2-integrin subunit CD18. J Immunol. 1995 Apr 01; 154(7):3461-70. PMID: 7534799.
    Citations: 53     Fields:    Translation:HumansCells
  25. Rieu P, Ueda T, Haruta I, Sharma CP, Arnaout MA. The A-domain of beta 2 integrin CR3 (CD11b/CD18) is a receptor for the hookworm-derived neutrophil adhesion inhibitor NIF. J Cell Biol. 1994 Dec; 127(6 Pt 2):2081-91. PMID: 7528750; PMCID: PMC2120307.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  26. Rabb H, Michishita M, Sharma CP, Brown D, Arnaout MA. Cytoplasmic tails of human complement receptor type 3 (CR3, CD11b/CD18) regulate ligand avidity and the internalization of occupied receptors. J Immunol. 1993 Jul 15; 151(2):990-1002. PMID: 8101539.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  27. Arnaout MA, Michishita M, Sharma CP. On the regulation of beta 2 integrins. Adv Exp Med Biol. 1992; 323:171-9. PMID: 1362476.
    Citations: 2     Fields:    Translation:Cells
  28. Sharma CP, Fox EA, Holmquist B, Jörnvall H, Vallee BL. cDNA sequence of human class III alcohol dehydrogenase. Biochem Biophys Res Commun. 1989 Oct 31; 164(2):631-7. PMID: 2818582.
    Citations: 10     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.