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William George Kaelin, M.D.

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Mentoring
Establishment of a Robust Xenograft Mouse Model of IDH-mutant Glioblastoma
Summer, 06/01/14 - 09/01/14

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35CA210068 (KAELIN, WILLIAM G.) Sep 1, 2016 - Aug 31, 2023
    NIH
    New Paradigms for Targeting Truncal Driver Mutations
    Role: Principal Investigator
  2. P50CA165962 (BATCHELOR, TRACY T) Sep 19, 2013 - Aug 31, 2024
    NIH
    SPORE: Targeted Therapies for Glioma
    Role: Co-Principal Investigator
  3. R21CA124988 (KAELIN, WILLIAM G) Dec 15, 2006 - Nov 30, 2008
    NIH
    A Luciferase Fusion Protein Library to Identify &Monitor Ubiquitylation Targets
    Role: Principal Investigator
  4. R13CA124261 (KAELIN, WILLIAM G) Jul 25, 2006 - Jun 30, 2007
    NIH
    2006 Cancer Model Mechanisms
    Role: Principal Investigator
  5. R33CA099069 (KAELIN, WILLIAM G) Jun 10, 2004 - Apr 30, 2007
    NIH
    Real-Time Imaging of Hypoxia based on VHL Activity
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Grubb T, Maganti S, Krill-Burger JM, Fraser C, Stransky L, Radivoyevitch T, Sarosiek KA, Vazquez F, Kaelin WG, Chakraborty AA. A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer. Clin Cancer Res. 2022 Jul 01. PMID: 35776130.
    Citations:    Fields:    
  2. Stransky LA, Vigeant SM, Huang B, West D, Denize T, Walton E, Signoretti S, Kaelin WG. Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway. Proc Natl Acad Sci U S A. 2022 04 05; 119(14):e2120403119. PMID: 35357972; PMCID: PMC9168943.
    Citations: 1     Fields:    Translation:HumansCells
  3. Choueiri TK, Albiges L, Atkins MB, Bakouny Z, Bratslavsky G, Braun DA, Haas NB, Haanen JBAG, Hakimi AA, Jewett MAS, Jonasch E, Kaelin WG, Kapur P, Labaki C, Lewis B, McDermott DF, Pal SK, Pels K, Poteat S, Powles T, Rathmell WK, Rini BI, Signoretti S, Tannir NM, Uzzo RG, Hammers HJ. From Basic Science to Clinical Translation in Kidney Cancer: A Report from the Second Kidney Cancer Research Summit. Clin Cancer Res. 2022 03 01; 28(5):831-839. PMID: 34965942; PMCID: PMC9223120.
    Citations:    Fields:    Translation:Humans
  4. Kaelin WG. David M. Livingston (1941-2021). Cell. 2021 12 09; 184(25):6007-6009. PMID: 34890547.
    Citations:    Fields:    
  5. Kamihara J, Hamilton KV, Pollard JA, Clinton CM, Madden JA, Lin J, Imamovic A, Wall CB, Wassner AJ, Weil BR, Heeney MM, Vargas SO, Kaelin WG, Janeway KA, Perini RF, Zojwalla NJ, Voss SD, DuBois SG. Belzutifan, a Potent HIF2a Inhibitor, in the Pacak-Zhuang Syndrome. N Engl J Med. 2021 11 25; 385(22):2059-2065. PMID: 34818480.
    Citations: 3     Fields:    Translation:HumansCells
  6. Koduri V, Duplaquet L, Lampson BL, Wang AC, Sabet AH, Ishoey M, Paulk J, Teng M, Harris IS, Endress JE, Liu X, Dasilva E, Paulo JA, Briggs KJ, Doench JG, Ott CJ, Zhang T, Donovan KA, Fischer ES, Gygi SP, Gray NS, Bradner J, Medin JA, Buhrlage SJ, Oser MG, Kaelin WG. Targeting oncoproteins with a positive selection assay for protein degraders. Sci Adv. 2021 02; 7(6). PMID: 33547076; PMCID: PMC7864573.
    Citations: 4     Fields:    Translation:HumansCells
  7. Liu J, Peng Y, Shi L, Wan L, Inuzuka H, Long J, Guo J, Zhang J, Yuan M, Zhang S, Wang X, Gao J, Dai X, Furumoto S, Jia L, Pandolfi PP, Asara JM, Kaelin WG, Liu J, Wei W. Author Correction: Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle. Cell Res. 2021 Jan; 31(1):104. PMID: 32859994.
    Citations:    Fields:    
  8. Losman JA, Koivunen P, Kaelin WG. 2-Oxoglutarate-dependent dioxygenases in cancer. Nat Rev Cancer. 2020 12; 20(12):710-726. PMID: 33087883.
    Citations: 34     Fields:    Translation:HumansCells
  9. Choueiri TK, Kaelin WG. Targeting the HIF2-VEGF axis in renal cell carcinoma. Nat Med. 2020 10; 26(10):1519-1530. PMID: 33020645.
    Citations: 78     Fields:    Translation:HumansCells
  10. Liu J, Peng Y, Shi L, Wan L, Inuzuka H, Long J, Guo J, Zhang J, Yuan M, Zhang S, Wang X, Gao J, Dai X, Furumoto S, Jia L, Pandolfi PP, Asara JM, Kaelin WG, Liu J, Wei W. Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle. Cell Res. 2021 01; 31(1):80-93. PMID: 32669607.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  11. Zhang H, Christensen CL, Dries R, Oser MG, Deng J, Diskin B, Li F, Pan Y, Zhang X, Yin Y, Papadopoulos E, Pyon V, Thakurdin C, Kwiatkowski N, Jani K, Rabin AR, Castro DM, Chen T, Silver H, Huang Q, Bulatovic M, Dowling CM, Sundberg B, Leggett A, Ranieri M, Han H, Li S, Yang A, Labbe KE, Almonte C, Sviderskiy VO, Quinn M, Donaghue J, Wang ES, Zhang T, He Z, Velcheti V, Hammerman PS, Freeman GJ, Bonneau R, Kaelin WG, Sutherland KD, Kersbergen A, Aguirre AJ, Yuan GC, Rothenberg E, Miller G, Gray NS, Wong KK. CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer. Cancer Cell. 2020 01 13; 37(1):37-54.e9. PMID: 31883968.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  12. Cable J, Finley L, Tu BP, Patti GJ, Oliver TG, Vardhana S, Mana M, Ericksen R, Khare S, DeBerardinis R, Stockwell BR, Edinger A, Haigis M, Kaelin W. Leveraging insights into cancer metabolism-a symposium report. Ann N Y Acad Sci. 2020 02; 1462(1):5-13. PMID: 31792987.
    Citations:    Fields:    Translation:HumansAnimals
  13. Oser MG, Sabet AH, Gao W, Chakraborty AA, Schinzel AC, Jennings RB, Fonseca R, Bonal DM, Booker MA, Flaifel A, Novak JS, Christensen CL, Zhang H, Herbert ZT, Tolstorukov MY, Buss EJ, Wong KK, Bronson RT, Nguyen QD, Signoretti S, Kaelin WG. The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis. Genes Dev. 2019 12 01; 33(23-24):1718-1738. PMID: 31727771; PMCID: PMC6942053.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  14. Nicholson HE, Tariq Z, Housden BE, Jennings RB, Stransky LA, Perrimon N, Signoretti S, Kaelin WG. HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species. Sci Signal. 2019 10 01; 12(601). PMID: 31575731.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  15. Sethi N, Kikuchi O, McFarland J, Zhang Y, Chung M, Kafker N, Islam M, Lampson B, Chakraborty A, Kaelin WG, Bass AJ. Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma. JCI Insight. 2019 08 08; 4(15). PMID: 31391338.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  16. Li S, Rodriguez J, Li W, Bullova P, Fell SM, Surova O, Westerlund I, Topcic D, Bergsland M, Stenman A, Muhr J, Nistér M, Holmberg J, Juhlin CC, Larsson C, von Kriegsheim A, Kaelin WG, Schlisio S. EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance. Proc Natl Acad Sci U S A. 2019 08 20; 116(34):16997-17006. PMID: 31375625; PMCID: PMC6708352.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  17. Chakraborty AA, Laukka T, Myllykoski M, Ringel AE, Booker MA, Tolstorukov MY, Meng YJ, Meier SR, Jennings RB, Creech AL, Herbert ZT, McBrayer SK, Olenchock BA, Jaffe JD, Haigis MC, Beroukhim R, Signoretti S, Koivunen P, Kaelin WG. Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate. Science. 2019 03 15; 363(6432):1217-1222. PMID: 30872525.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  18. Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG, Brugge JS. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Cell Metab. 2019 05 07; 29(5):1166-1181.e6. PMID: 30799286; PMCID: PMC6506399.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  19. Koduri V, McBrayer SK, Liberzon E, Wang AC, Briggs KJ, Cho H, Kaelin WG. Peptidic degron for IMiD-induced degradation of heterologous proteins. Proc Natl Acad Sci U S A. 2019 02 12; 116(7):2539-2544. PMID: 30683719; PMCID: PMC6377458.
    Citations: 11     Fields:    Translation:AnimalsCells
  20. Oser MG, Fonseca R, Chakraborty AA, Brough R, Spektor A, Jennings RB, Flaifel A, Novak JS, Gulati A, Buss E, Younger ST, McBrayer SK, Cowley GS, Bonal DM, Nguyen QD, Brulle-Soumare L, Taylor P, Cairo S, Ryan CJ, Pease EJ, Maratea K, Travers J, Root DE, Signoretti S, Pellman D, Ashton S, Lord CJ, Barry ST, Kaelin WG. Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival. Cancer Discov. 2019 02; 9(2):230-247. PMID: 30373918; PMCID: PMC6368871.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  21. Li AG, Murphy EC, Culhane AC, Powell E, Wang H, Bronson RT, Von T, Giobbie-Hurder A, Gelman RS, Briggs KJ, Piwnica-Worms H, Zhao JJ, Kung AL, Kaelin WG, Livingston DM. BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1a activation. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):E9600-E9609. PMID: 30254159; PMCID: PMC6187201.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  22. McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG. Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. Cell. 2018 09 20; 175(1):101-116.e25. PMID: 30220459; PMCID: PMC6219629.
    Citations: 110     Fields:    Translation:HumansCells
  23. Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, Liu XD, Jonasch E, Xie L, Chen X, Yao X, Teh BT, Tan P, Zheng X, Li M, Lawrence C, Fan J, Geng J, Liu X, Hu L, Wang J, Liao C, Hong K, Zurlo G, Parker JS, Auman JT, Perou CM, Rathmell WK, Kim WY, Kirschner MW, Kaelin WG, Baldwin AS, Zhang Q. VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma. Science. 2018 07 20; 361(6399):290-295. PMID: 30026228.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  24. McBrayer SK, Olenchock BA, DiNatale GJ, Shi DD, Khanal J, Jennings RB, Novak JS, Oser MG, Robbins AK, Modiste R, Bonal D, Moslehi J, Bronson RT, Neuberg D, Nguyen QD, Signoretti S, Losman JA, Kaelin WG. Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):E3741-E3748. PMID: 29610306; PMCID: PMC5910822.
    Citations: 6     Fields:    Translation:AnimalsCells
  25. Kaelin WG. HIF2 Inhibitor Joins the Kidney Cancer Armamentarium. J Clin Oncol. 2018 03 20; 36(9):908-910. PMID: 29384723.
    Citations: 7     Fields:    Translation:Humans
  26. Miao D, Margolis CA, Gao W, Voss MH, Li W, Martini DJ, Norton C, Bossé D, Wankowicz SM, Cullen D, Horak C, Wind-Rotolo M, Tracy A, Giannakis M, Hodi FS, Drake CG, Ball MW, Allaf ME, Snyder A, Hellmann MD, Ho T, Motzer RJ, Signoretti S, Kaelin WG, Choueiri TK, Van Allen EM. Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma. Science. 2018 Feb 16; 359(6377):801-806. PMID: 29301960; PMCID: PMC6035749.
    Citations: 392     Fields:    Translation:Humans
  27. Kaelin WG. Senator McCain and Our Shared Humanity. Am J Med. 2018 03; 131(3):216-217. PMID: 29229468.
    Citations:    Fields:    Translation:Humans
  28. Kaelin WG. Climate Change: What Would Lincoln Do? JAMA. 2017 Aug 15; 318(7):611. PMID: 28810027.
    Citations:    Fields:    Translation:Humans
  29. Chakraborty AA, Nakamura E, Qi J, Creech A, Jaffe JD, Paulk J, Novak JS, Nagulapalli K, McBrayer SK, Cowley GS, Pineda J, Song J, Wang YE, Carr SA, Root DE, Signoretti S, Bradner JE, Kaelin WG. HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase. Sci Transl Med. 2017 07 12; 9(398). PMID: 28701475.
    Citations: 15     Fields:    Translation:HumansCells
  30. Ivan M, Kaelin WG. The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks. Mol Cell. 2017 Jun 15; 66(6):772-779. PMID: 28622522; PMCID: PMC5613951.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  31. Kaelin WG. Publish houses of brick, not mansions of straw. Nature. 2017 05 23; 545(7655):387. PMID: 28541345.
    Citations: 7     Fields:    
  32. Kaelin WG. Common pitfalls in preclinical cancer target validation. Nat Rev Cancer. 2017 07; 17(7):425-440. PMID: 28524181.
    Citations: 54     Fields:    Translation:Humans
  33. Gao W, Li W, Xiao T, Liu XS, Kaelin WG. Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/- clear cell renal carcinoma. Proc Natl Acad Sci U S A. 2017 01 31; 114(5):1027-1032. PMID: 28082722; PMCID: PMC5293026.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  34. Kaelin WG. The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer. Trans Am Clin Climatol Assoc. 2017; 128:298-307. PMID: 28790514; PMCID: PMC5525432.
    Citations: 48     Fields:    Translation:Humans
  35. Cho H, Kaelin WG. Targeting HIF2 in Clear Cell Renal Cell Carcinoma. Cold Spring Harb Symp Quant Biol. 2016; 81:113-121. PMID: 27932568.
    Citations: 15     Fields:    Translation:HumansAnimals
  36. Kaelin WG, Ratcliffe PJ, Semenza GL. Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award. JAMA. 2016 Sep 27; 316(12):1252-3. PMID: 27622845.
    Citations: 18     Fields:    Translation:HumansAnimals
  37. German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, Kaelin WG, Haigis MC. PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2. Mol Cell. 2016 09 15; 63(6):1006-20. PMID: 27635760; PMCID: PMC5040345.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  38. Cho H, Du X, Rizzi JP, Liberzon E, Chakraborty AA, Gao W, Carvo I, Signoretti S, Bruick RK, Josey JA, Wallace EM, Kaelin WG. On-target efficacy of a HIF-2a antagonist in preclinical kidney cancer models. Nature. 2016 11 03; 539(7627):107-111. PMID: 27595393; PMCID: PMC5499381.
    Citations: 178     Fields:    Translation:HumansAnimalsCells
  39. Guo J, Chakraborty AA, Liu P, Gan W, Zheng X, Inuzuka H, Wang B, Zhang J, Zhang L, Yuan M, Novak J, Cheng JQ, Toker A, Signoretti S, Zhang Q, Asara JM, Kaelin WG, Wei W. pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner. Science. 2016 08 26; 353(6302):929-32. PMID: 27563096.
    Citations: 91     Fields:    Translation:HumansCells
  40. Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG. Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine. Cell. 2016 Jun 30; 166(1):126-39. PMID: 27368101; PMCID: PMC4930557.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  41. Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG. EGLN1 Inhibition and Rerouting of a-Ketoglutarate Suffice for Remote Ischemic Protection. Cell. 2016 Apr 07; 165(2):497. PMID: 27058668.
    Citations: 12     Fields:    
  42. Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG. EGLN1 Inhibition and Rerouting of a-Ketoglutarate Suffice for Remote Ischemic Protection. Cell. 2016 Feb 25; 164(5):884-95. PMID: 26919427; PMCID: PMC4819986.
    Citations: 50     Fields:    Translation:Animals
  43. Laukka T, Mariani CJ, Ihantola T, Cao JZ, Hokkanen J, Kaelin WG, Godley LA, Koivunen P. Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes. J Biol Chem. 2016 Feb 19; 291(8):4256-65. PMID: 26703470.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  44. Zhang C, Li X, Adelmant G, Dobbins J, Geisen C, Oser MG, Wucherpfenning KW, Marto JA, Kaelin WG. Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15372-7. PMID: 26631746; PMCID: PMC4687553.
    Citations: 7     Fields:    Translation:HumansCells
  45. Andronesi OC, Loebel F, Bogner W, Marjanska M, Vander Heiden MG, Iafrate AJ, Dietrich J, Batchelor TT, Gerstner ER, Kaelin WG, Chi AS, Rosen BR, Cahill DP. Treatment Response Assessment in IDH-Mutant Glioma Patients by Noninvasive 3D Functional Spectroscopic Mapping of 2-Hydroxyglutarate. Clin Cancer Res. 2016 Apr 01; 22(7):1632-41. PMID: 26534967; PMCID: PMC4818725.
    Citations: 64     Fields:    Translation:Humans
  46. Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, Wen H, Liu Y, Wang C, Pestell RG, Aird KM, Kaelin WG, Liu XS, Zhang Q. EglN2 associates with the NRF1-PGC1a complex and controls mitochondrial function in breast cancer. EMBO J. 2015 Dec 02; 34(23):2953-70. PMID: 26492917.
    Citations: 38     Fields:    Translation:HumansCells
  47. Suhara T, Hishiki T, Kasahara M, Hayakawa N, Oyaizu T, Nakanishi T, Kubo A, Morisaki H, Kaelin WG, Suematsu M, Minamishima YA. Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle. Proc Natl Acad Sci U S A. 2015 Sep 15; 112(37):11642-7. PMID: 26324945; PMCID: PMC4577207.
    Citations: 16     Fields:    Translation:AnimalsCells
  48. Kaelin WG. DisABLing kidney cancers caused by fumarate hydratase mutations. Cancer Cell. 2014 Dec 08; 26(6):779-780. PMID: 25490441.
    Citations: 1     Fields:    Translation:HumansAnimals
  49. Couvé S, Ladroue C, Laine E, Mahtouk K, Guégan J, Gad S, Le Jeune H, Le Gentil M, Nuel G, Kim WY, Lecomte B, Pagès JC, Collin C, Lasne F, Benusiglio PR, Bressac-de Paillerets B, Feunteun J, Lazar V, Gimenez-Roqueplo AP, Mazure NM, Dessen P, Tchertanov L, Mole DR, Kaelin W, Ratcliffe P, Richard S, Gardie B. Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis. Cancer Res. 2014 Nov 15; 74(22):6554-64. PMID: 25371412; PMCID: PMC5555745.
    Citations: 18     Fields:    Translation:HumansCells
  50. Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin WG, Koivunen P, Prchal JT. A genetic mechanism for Tibetan high-altitude adaptation. Nat Genet. 2014 Sep; 46(9):951-6. PMID: 25129147; PMCID: PMC4473257.
    Citations: 160     Fields:    Translation:Humans
  51. Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, Lim E, Liu W, Bronson RT, Bowden M, Brock J, Krop IE, Dillon DA, Gygi SP, Mills GB, Richardson AL, Signoretti S, Yaffe MB, Kaelin WG. Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell. 2014 Aug 11; 26(2):222-34. PMID: 25117710.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  52. Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG, Zhang Q. Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes Dev. 2014 Jul 01; 28(13):1429-44. PMID: 24990963.
    Citations: 63     Fields:    Translation:AnimalsCells
  53. Choueiri TK, Pal SK, McDermott DF, Morrissey S, Ferguson KC, Holland J, Kaelin WG, Dutcher JP. A phase I study of cabozantinib (XL184) in patients with renal cell cancer. Ann Oncol. 2014 Aug; 25(8):1603-8. PMID: 24827131.
    Citations: 56     Fields:    Translation:HumansCTClinical Trials
  54. Akbay EA, Moslehi J, Christensen CL, Saha S, Tchaicha JH, Ramkissoon SH, Stewart KM, Carretero J, Kikuchi E, Zhang H, Cohoon TJ, Murray S, Liu W, Uno K, Fisch S, Jones K, Gurumurthy S, Gliser C, Choe S, Keenan M, Son J, Stanley I, Losman JA, Padera R, Bronson RT, Asara JM, Abdel-Wahab O, Amrein PC, Fathi AT, Danial NN, Kimmelman AC, Kung AL, Ligon KL, Yen KE, Kaelin WG, Bardeesy N, Wong KK. D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. Genes Dev. 2014 Mar 01; 28(5):479-90. PMID: 24589777.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  55. Li L, Shen C, Nakamura E, Ando K, Signoretti S, Beroukhim R, Cowley GS, Lizotte P, Liberzon E, Bair S, Root DE, Tamayo P, Tsherniak A, Cheng SC, Tabak B, Jacobsen A, Hakimi AA, Schultz N, Ciriello G, Sander C, Hsieh JJ, Kaelin WG. SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer. Cancer Cell. 2013 Dec 09; 24(6):738-50. PMID: 24332042; PMCID: PMC3910168.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  56. Lu G, Middleton RE, Sun H, Naniong M, Ott CJ, Mitsiades CS, Wong KK, Bradner JE, Kaelin WG. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Science. 2014 Jan 17; 343(6168):305-9. PMID: 24292623; PMCID: PMC4070318.
    Citations: 519     Fields:    Translation:HumansCells
  57. Kaelin W, Livingston D, Loda M, Vousden K, Mihich E. Twenty-fifth annual Pezcoller Symposium: Metabolism and tumorigenesis. Cancer Res. 2013 Oct 15; 73(20):6124-7. PMID: 24097824.
    Citations:    Fields:    Translation:HumansAnimals
  58. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature. 2013 Jul 04; 499(7456):43-9. PMID: 23792563.
    Citations: 1409     Fields:    Translation:HumansCells
  59. Losman JA, Kaelin WG. What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes Dev. 2013 Apr 15; 27(8):836-52. PMID: 23630074; PMCID: PMC3650222.
    Citations: 280     Fields:    Translation:HumansAnimalsCells
  60. Kaelin WG, McKnight SL. Influence of metabolism on epigenetics and disease. Cell. 2013 Mar 28; 153(1):56-69. PMID: 23540690; PMCID: PMC3775362.
    Citations: 370     Fields:    Translation:HumansAnimalsCells
  61. Losman JA, Looper RE, Koivunen P, Lee S, Schneider RK, McMahon C, Cowley GS, Root DE, Ebert BL, Kaelin WG. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013 Mar 29; 339(6127):1621-5. PMID: 23393090; PMCID: PMC3836459.
    Citations: 334     Fields:    Translation:HumansCells
  62. Beshiri ML, Holmes KB, Richter WF, Hess S, Islam AB, Yan Q, Plante L, Litovchick L, Gévry N, Lopez-Bigas N, Kaelin WG, Benevolenskaya EV. Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18499-504. PMID: 23093672.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  63. Kaelin WG. Molecular biology. Use and abuse of RNAi to study mammalian gene function. Science. 2012 Jul 27; 337(6093):421-2. PMID: 22837515; PMCID: PMC3705935.
    Citations: 87     Fields:    Translation:HumansAnimals
  64. Shen C, Kaelin WG. The VHL/HIF axis in clear cell renal carcinoma. Semin Cancer Biol. 2013 Feb; 23(1):18-25. PMID: 22705278; PMCID: PMC3663044.
    Citations: 155     Fields:    Translation:Humans
  65. Querbes W, Bogorad RL, Moslehi J, Wong J, Chan AY, Bulgakova E, Kuchimanchi S, Akinc A, Fitzgerald K, Koteliansky V, Kaelin WG. Treatment of erythropoietin deficiency in mice with systemically administered siRNA. Blood. 2012 Aug 30; 120(9):1916-22. PMID: 22611156; PMCID: PMC3433093.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  66. Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, Losman JA, Joensuu P, Bergmann U, Gross S, Travins J, Weiss S, Looper R, Ligon KL, Verhaak RG, Yan H, Kaelin WG. Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. Nature. 2012 Feb 15; 483(7390):484-8. PMID: 22343896; PMCID: PMC3656605.
    Citations: 370     Fields:    Translation:HumansCells
  67. Kaelin WG. Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases. Cold Spring Harb Symp Quant Biol. 2011; 76:335-45. PMID: 22089927; PMCID: PMC4197849.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  68. Bass AJ, Lawrence MS, Brace LE, Ramos AH, Drier Y, Cibulskis K, Sougnez C, Voet D, Saksena G, Sivachenko A, Jing R, Parkin M, Pugh T, Verhaak RG, Stransky N, Boutin AT, Barretina J, Solit DB, Vakiani E, Shao W, Mishina Y, Warmuth M, Jimenez J, Chiang DY, Signoretti S, Kaelin WG, Spardy N, Hahn WC, Hoshida Y, Ogino S, DePinho RA, Chin L, Garraway LA, Fuchs CS, Baselga J, Tabernero J, Gabriel S, Lander ES, Getz G, Meyerson M. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nat Genet. 2011 Sep 04; 43(10):964-968. PMID: 21892161.
    Citations: 172     Fields:    Translation:HumansCells
  69. Li L, Kaelin WG. New insights into the biology of renal cell carcinoma. Hematol Oncol Clin North Am. 2011 Aug; 25(4):667-86. PMID: 21763962; PMCID: PMC3161447.
    Citations: 37     Fields:    Translation:Humans
  70. Lin W, Cao J, Liu J, Beshiri ML, Fujiwara Y, Francis J, Cherniack AD, Geisen C, Blair LP, Zou MR, Shen X, Kawamori D, Liu Z, Grisanzio C, Watanabe H, Minamishima YA, Zhang Q, Kulkarni RN, Signoretti S, Rodig SJ, Bronson RT, Orkin SH, Tuck DP, Benevolenskaya EV, Meyerson M, Kaelin WG, Yan Q. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13379-86. PMID: 21788502.
    Citations: 75     Fields:    Translation:AnimalsCells
  71. Shen C, Beroukhim R, Schumacher SE, Zhou J, Chang M, Signoretti S, Kaelin WG. Genetic and functional studies implicate HIF1a as a 14q kidney cancer suppressor gene. Cancer Discov. 2011 Aug; 1(3):222-35. PMID: 22037472; PMCID: PMC3202343.
    Citations: 193     Fields: