Harvard Catalyst Profiles

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Sarah E Keates, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03DK083975 (KEATES, SARAH E.) Jul 1, 2009 - Dec 30, 2011
    NIH
    The central role of c-Met in H. pylori pathogenesis.
    Role: Principal Investigator
  2. K01DK075942 (KEATES, SARAH E.) Aug 1, 2006 - Dec 31, 2011
    NIH
    The role of Plasminogen activator Inhibitor-1 in Helicobacter pylori infection.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li J, Fredericks M, Cannell M, Wang K, Sako D, Maguire MC, Grenha R, Liharska K, Krishnan L, Bloom T, Belcheva EP, Martinez PA, Castonguay R, Keates S, Alexander MJ, Choi H, Grinberg AV, Pearsall RS, Oh P, Kumar R, Suragani RN. ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders. J Clin Invest. 2021 02 15; 131(4). PMID: 33586684; PMCID: PMC7880416.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  2. Celli JP, Turner BS, Afdhal NH, Keates S, Ghiran I, Kelly CP, Ewoldt RH, McKinley GH, So P, Erramilli S, Bansil R. Helicobacter pylori moves through mucus by reducing mucin viscoelasticity. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14321-6. PMID: 19706518.
    Citations: 122     Fields:    Translation:AnimalsCells
  3. Keates AC, Tummala S, Peek RM, Csizmadia E, Kunzli B, Becker K, Correa P, Romero-Gallo J, Piazuelo MB, Sheth S, Kelly CP, Robson SC, Keates S. Helicobacter pylori infection stimulates plasminogen activator inhibitor 1 production by gastric epithelial cells. Infect Immun. 2008 Sep; 76(9):3992-9. PMID: 18519558.
    Citations: 10     Fields:    Translation:HumansCells
  4. Keates S, Han X, Kelly CP, Keates AC. Macrophage-inflammatory protein-3alpha mediates epidermal growth factor receptor transactivation and ERK1/2 MAPK signaling in Caco-2 colonic epithelial cells via metalloproteinase-dependent release of amphiregulin. J Immunol. 2007 Jun 15; 178(12):8013-21. PMID: 17548638.
    Citations: 12     Fields:    Translation:HumansCells
  5. Keates S, Keates AC, Katchar K, Peek RM, Kelly CP. Helicobacter pylori induces up-regulation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Infect Dis. 2007 Jul 01; 196(1):95-103. PMID: 17538889.
    Citations: 25     Fields:    Translation:HumansCells
  6. Fang H, Qiu L, Vitkin E, Zaman MM, Andersson C, Salahuddin S, Kimerer LM, Cipolloni PB, Modell MD, Turner BS, Keates SE, Bigio I, Itzkan I, Freedman SD, Bansil R, Hanlon EB, Perelman LT. Confocal light absorption and scattering spectroscopic microscopy. Appl Opt. 2007 Apr 01; 46(10):1760-9. PMID: 17356619.
    Citations: 17     Fields:    
  7. Katchar K, Kelly CP, Keates S, O'brien MJ, Keates AC. MIP-3alpha neutralizing monoclonal antibody protects against TNBS-induced colonic injury and inflammation in mice. Am J Physiol Gastrointest Liver Physiol. 2007 May; 292(5):G1263-71. PMID: 17272517.
    Citations: 23     Fields:    Translation:AnimalsCells
  8. Sougioultzis S, Simeonidis S, Bhaskar KR, Chen X, Anton PM, Keates S, Pothoulakis C, Kelly CP. Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression. Biochem Biophys Res Commun. 2006 Apr 28; 343(1):69-76. PMID: 16529714.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  9. Keates S, Keates AC, Nath S, Peek RM, Kelly CP. Transactivation of the epidermal growth factor receptor by cag+ Helicobacter pylori induces upregulation of the early growth response gene Egr-1 in gastric epithelial cells. Gut. 2005 Oct; 54(10):1363-9. PMID: 15863471; PMCID: PMC1774684.
    Citations: 20     Fields:    Translation:HumansCells
  10. Sougioultzis S, Kyne L, Drudy D, Keates S, Maroo S, Pothoulakis C, Giannasca PJ, Lee CK, Warny M, Monath TP, Kelly CP. Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea. Gastroenterology. 2005 Mar; 128(3):764-70. PMID: 15765411.
    Citations: 77     Fields:    Translation:HumansCellsCTClinical Trials
  11. Tummala S, Keates S, Kelly CP. Update on the immunologic basis of Helicobacter pylori gastritis. Curr Opin Gastroenterol. 2004 Nov; 20(6):592-7. PMID: 15703688.
    Citations: 9     Fields:    
  12. Zhao D, Zhan Y, Koon HW, Zeng H, Keates S, Moyer MP, Pothoulakis C. Metalloproteinase-dependent transforming growth factor-alpha release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells. J Biol Chem. 2004 Oct 15; 279(42):43547-54. PMID: 15247267.
    Citations: 21     Fields:    Translation:HumansCells
  13. Keates SE, Kostman TA, Anderson JD, Bailey BA. Altered gene expression in three plant species in response to treatment with Nep1, a fungal protein that causes necrosis. Plant Physiol. 2003 Jul; 132(3):1610-22. PMID: 12857840; PMCID: PMC167098.
    Citations: 20     Fields:    Translation:AnimalsCells
  14. Kwon JH, Keates S, Bassani L, Mayer LF, Keates AC. Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP-3alpha) production in normal colon and inflammatory bowel disease. Gut. 2002 Dec; 51(6):818-26. PMID: 12427784; PMCID: PMC1773480.
    Citations: 50     Fields:    Translation:HumansCells
  15. Kwon JH, Keates S, Simeonidis S, Grall F, Libermann TA, Keates AC. ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells. J Biol Chem. 2003 Jan 10; 278(2):875-84. PMID: 12414801.
    Citations: 21     Fields:    Translation:HumansCells
  16. He D, Sougioultzis S, Hagen S, Liu J, Keates S, Keates AC, Pothoulakis C, Lamont JT. Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation. Gastroenterology. 2002 Apr; 122(4):1048-57. PMID: 11910356.
    Citations: 42     Fields:    Translation:HumansCells
  17. Keates S, Sougioultzis S, Keates AC, Zhao D, Peek RM, Shaw LM, Kelly CP. cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Biol Chem. 2001 Dec 21; 276(51):48127-34. PMID: 11604402.
    Citations: 75     Fields:    Translation:HumansCells
  18. Keates AC, Keates S, Kwon JH, Arseneau KO, Law DJ, Bai L, Merchant JL, Wang TC, Kelly CP. ZBP-89, Sp1, and nuclear factor-kappa B regulate epithelial neutrophil-activating peptide-78 gene expression in Caco-2 human colonic epithelial cells. J Biol Chem. 2001 Nov 23; 276(47):43713-22. PMID: 11559712.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  19. Warny M, Keates AC, Keates S, Castagliuolo I, Zacks JK, Aboudola S, Qamar A, Pothoulakis C, LaMont JT, Kelly CP. p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis. J Clin Invest. 2000 Apr; 105(8):1147-56. PMID: 10772660; PMCID: PMC300827.
    Citations: 80     Fields:    Translation:AnimalsCells
  20. Keates S, Keates AC, Warny M, Peek RM, Murray PG, Kelly CP. Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori. J Immunol. 1999 Nov 15; 163(10):5552-9. PMID: 10553083.
    Citations: 82     Fields:    Translation:HumansCells
  21. Bliss CM, Golenbock DT, Keates S, Linevsky JK, Kelly CP. Helicobacter pylori lipopolysaccharide binds to CD14 and stimulates release of interleukin-8, epithelial neutrophil-activating peptide 78, and monocyte chemotactic protein 1 by human monocytes. Infect Immun. 1998 Nov; 66(11):5357-63. PMID: 9784544; PMCID: PMC108670.
    Citations: 26     Fields:    Translation:HumansCells
  22. Linevsky JK, Pothoulakis C, Keates S, Warny M, Keates AC, Lamont JT, Kelly CP. IL-8 release and neutrophil activation by Clostridium difficile toxin-exposed human monocytes. Am J Physiol. 1997 12; 273(6):G1333-40. PMID: 9435559.
    Citations: 33     Fields:    Translation:HumansCells
  23. Keates S, Hitti YS, Upton M, Kelly CP. Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells. Gastroenterology. 1997 Oct; 113(4):1099-109. PMID: 9322504.
    Citations: 111     Fields:    Translation:HumansCells
  24. Salcedo J, Keates S, Pothoulakis C, Warny M, Castagliuolo I, LaMont JT, Kelly CP. Intravenous immunoglobulin therapy for severe Clostridium difficile colitis. Gut. 1997 Sep; 41(3):366-70. PMID: 9378393; PMCID: PMC1891485.
    Citations: 64     Fields:    Translation:HumansCells
  25. Keates S, Keates AC, Mizoguchi E, Bhan A, Kelly CP. Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis. Am J Physiol. 1997 Jul; 273(1 Pt 1):G75-82. PMID: 9252512.
    Citations: 31     Fields:    Translation:HumansCells
  26. Kelly CP, Chetham S, Keates S, Bostwick EF, Roush AM, Castagliuolo I, LaMont JT, Pothoulakis C. Survival of anti-Clostridium difficile bovine immunoglobulin concentrate in the human gastrointestinal tract. Antimicrob Agents Chemother. 1997 Feb; 41(2):236-41. PMID: 9021173; PMCID: PMC163695.
    Citations: 24     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  27. Kelly CP, Pothoulakis C, Vavva F, Castagliuolo I, Bostwick EF, O'Keane JC, Keates S, LaMont JT. Anti-Clostridium difficile bovine immunoglobulin concentrate inhibits cytotoxicity and enterotoxicity of C. difficile toxins. Antimicrob Agents Chemother. 1996 Feb; 40(2):373-9. PMID: 8834883; PMCID: PMC163119.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  28. Kelly CP, Keates S, Siegenberg D, Linevsky JK, Pothoulakis C, Brady HR. IL-8 secretion and neutrophil activation by HT-29 colonic epithelial cells. Am J Physiol. 1994 Dec; 267(6 Pt 1):G991-7. PMID: 7810667.
    Citations: 18     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.