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profileBryan P. Hurley, PH.D.

TitleAssistant Professor of Pediatrics
InstitutionMassachusetts General Hospital
DepartmentPediatrics
AddressMassachusetts General Hospital
Bldg 114-3503, Mucosal Immun. Labs
114 16th Street
Charlestown MA 02129
Phone617/726-3101
Fax617/726-4172
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R25DK103579     (HURLEY, BRYAN P)Mar 1, 2015 - Feb 29, 2020
NIH/NIDDK
MGHfC Digestive Disease Summer Research Program
Role: Principal Investigator

R01AI095338     (HURLEY, BRYAN P)Feb 8, 2012 - Jan 31, 2017
NIH/NIAID
The Role of Hepoxilin A3 in Neutrophil Breach of the Infected Airway Mucosa
Role: Principal Investigator

K22AI065425     (HURLEY, BRYAN P)Feb 15, 2008 - May 31, 2010
NIH/NIAID
Eicosanoid Production By Infected Lung Epithelial Cells
Role: Principal Investigator

F32AI054054     (HURLEY, BRYAN P)Jul 1, 2003 - Jun 30, 2005
NIH/NIAID
Airway Inflammation: Bacterial Epithelial Interactions
Role: Principal Investigator

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Yonker LM, Mou H, Chu KK, Pazos MA, Leung H, Cui D, Ryu J, Hibbler RM, Eaton AD, Ford TN, Falck JR, Kinane TB, Tearney GJ, Rajagopal J, Hurley BP. Development of a Primary Human Co-Culture Model of Inflamed Airway Mucosa. Sci Rep. 2017 Aug 15; 7(1):8182. PMID: 28811631.
    View in: PubMed
  2. Pazos MA, Lanter BB, Yonker LM, Eaton AD, Pirzai W, Gronert K, Bonventre JV, Hurley BP. Pseudomonas aeruginosa ExoU augments neutrophil transepithelial migration. PLoS Pathog. 2017 Aug; 13(8):e1006548. PMID: 28771621.
    View in: PubMed
  3. Eaton AD, Zimmermann C, Delaney B, Hurley BP. Primary human polarized small intestinal epithelial barriers respond differently to a hazardous and an innocuous protein. Food Chem Toxicol. 2017 Aug; 106(Pt A):70-77. PMID: 28533127.
    View in: PubMed
  4. Chu KK, Kusek ME, Liu L, Som A, Yonker LM, Leung H, Cui D, Ryu J, Eaton AD, Tearney GJ, Hurley BP. Illuminating dynamic neutrophil trans-epithelial migration with micro-optical coherence tomography. Sci Rep. 2017 Apr 03; 8:45789. PMID: 28368012.
    View in: PubMed
  5. Hurley BP, Eaton AD, Zimmermann C, Delaney B. Polarized monolayer cultures of human intestinal epithelial cell lines exposed to intractable proteins - In vitro hazard identification studies. Food Chem Toxicol. 2016 Dec; 98(Pt B):262-268. PMID: 27832974.
    View in: PubMed
  6. Chen K, Shanmugam NK, Pazos MA, Hurley BP, Cherayil BJ. Commensal Bacteria-Induced Inflammasome Activation in Mouse and Human Macrophages Is Dependent on Potassium Efflux but Does Not Require Phagocytosis or Bacterial Viability. PLoS One. 2016; 11(8):e0160937. PMID: 27505062; PMCID: PMC4978417.
  7. Johnston N, Ondrey F, Rosen R, Hurley BP, Gould J, Allen J, DelGaudio J, Altman KW. Airway reflux. Ann N Y Acad Sci. 2016 Oct; 1381(1):5-13. PMID: 27310222.
    View in: PubMed
  8. Hurley BP, Pirzai W, Eaton AD, Harper M, Roper J, Zimmermann C, Ladics GS, Layton RJ, Delaney B. An experimental platform using human intestinal epithelial cell lines to differentiate between hazardous and non-hazardous proteins. Food Chem Toxicol. 2016 Jun; 92:75-87. PMID: 27060235.
    View in: PubMed
  9. Yonker LM, Cigana C, Hurley BP, Bragonzi A. Host-pathogen interplay in the respiratory environment of cystic fibrosis. J Cyst Fibros. 2015 Jul; 14(4):431-439. PMID: 25800687; PMCID: PMC4485938.
  10. Pazos MA, Pirzai W, Yonker LM, Morisseau C, Gronert K, Hurley BP. Distinct cellular sources of hepoxilin A3 and leukotriene B4 are used to coordinate bacterial-induced neutrophil transepithelial migration. J Immunol. 2015 Feb 01; 194(3):1304-15. PMID: 25548217; PMCID: PMC4297725 [Available on 02/01/16].
  11. Kusek ME, Pazos MA, Pirzai W, Hurley BP. In vitro coculture assay to assess pathogen induced neutrophil trans-epithelial migration. J Vis Exp. 2014 Jan 06; (83):e50823. PMID: 24430378; PMCID: PMC4063550.
  12. Kubala SA, Patil SU, Shreffler WG, Hurley BP. Pathogen induced chemo-attractant hepoxilin A3 drives neutrophils, but not eosinophils across epithelial barriers. Prostaglandins Other Lipid Mediat. 2014 Jan; 108:1-8. PMID: 24315875; PMCID: PMC4004677.
  13. Bhowmick R, Maung N, Hurley BP, Ghanem EB, Gronert K, McCormick BA, Leong JM. Systemic disease during Streptococcus pneumoniae acute lung infection requires 12-lipoxygenase-dependent inflammation. J Immunol. 2013 Nov 15; 191(10):5115-23. PMID: 24089193; PMCID: PMC3836588.
  14. Trebicka E, Jacob S, Pirzai W, Hurley BP, Cherayil BJ. Role of antilipopolysaccharide antibodies in serum bactericidal activity against Salmonella enterica serovar Typhimurium in healthy adults and children in the United States. Clin Vaccine Immunol. 2013 Oct; 20(10):1491-8. PMID: 23803904; PMCID: PMC3807195.
  15. Tamang DL, Pirzai W, Priebe GP, Traficante DC, Pier GB, Falck JR, Morisseau C, Hammock BD, McCormick BA, Gronert K, Hurley BP. Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers. J Immunol. 2012 Nov 15; 189(10):4960-9. PMID: 23045615; PMCID: PMC3490410.
  16. Hurley BP, Pirzai W, Mumy KL, Gronert K, McCormick BA. Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Feb; 300(2):L286-94. PMID: 21097525; PMCID: PMC3043809.
  17. Hurley BP, Goodman AL, Mumy KL, Murphy P, Lory S, McCormick BA. The two-component sensor response regulator RoxS/RoxR plays a role in Pseudomonas aeruginosa interactions with airway epithelial cells. Microbes Infect. 2010 Mar; 12(3):190-8. PMID: 19961952; PMCID: PMC2826603.
  18. Mumy KL, Bien JD, Pazos MA, Gronert K, Hurley BP, McCormick BA. Distinct isoforms of phospholipase A2 mediate the ability of Salmonella enterica serotype typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophils. Infect Immun. 2008 Aug; 76(8):3614-27. PMID: 18505810; PMCID: PMC2493202.
  19. Hurley BP, McCormick BA. Multiple roles of phospholipase A2 during lung infection and inflammation. Infect Immun. 2008 Jun; 76(6):2259-72. PMID: 18411286; PMCID: PMC2423084.
  20. Hurley BP, Sin A, McCormick BA. Adhesion molecules involved in hepoxilin A3-mediated neutrophil transepithelial migration. Clin Exp Immunol. 2008 Feb; 151(2):297-305. PMID: 18005361; PMCID: PMC2276941.
  21. Köhler H, Sakaguchi T, Hurley BP, Kase BA, Kase BJ, Reinecker HC, McCormick BA. Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passage. Am J Physiol Gastrointest Liver Physiol. 2007 Jul; 293(1):G178-87. PMID: 17615177.
    View in: PubMed
  22. Hurley BP, Williams NL, McCormick BA. Involvement of phospholipase A2 in Pseudomonas aeruginosa-mediated PMN transepithelial migration. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L703-L709. PMID: 16272174.
    View in: PubMed
  23. Hurley BP, Siccardi D, Mrsny RJ, McCormick BA. Polymorphonuclear cell transmigration induced by Pseudomonas aeruginosa requires the eicosanoid hepoxilin A3. J Immunol. 2004 Nov 01; 173(9):5712-20. PMID: 15494523.
    View in: PubMed
  24. Hurley BP, McCormick BA. Intestinal epithelial defense systems protect against bacterial threats. Curr Gastroenterol Rep. 2004 Oct; 6(5):355-61. PMID: 15341710.
    View in: PubMed
  25. Spacek LA, Hurley BP, Acheson DW, Granok A, Currie A, Doing K, Sears CL. Shiga toxin-producing Escherichia coli as a possible etiological agent of chronic diarrhea. Clin Infect Dis. 2004 Sep 01; 39(5):e46-8. PMID: 15356801.
    View in: PubMed
  26. Mrsny RJ, Gewirtz AT, Siccardi D, Savidge T, Hurley BP, Madara JL, McCormick BA. Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7421-6. PMID: 15123795; PMCID: PMC409934.
  27. Hurley BP, McCormick BA. Translating tissue culture results into animal models: the case of Salmonella typhimurium. Trends Microbiol. 2003 Dec; 11(12):562-9. PMID: 14659688.
    View in: PubMed
  28. Thorpe CM, Hurley BP, Acheson DW. Shiga toxin interactions with the intestinal epithelium. Methods Mol Med. 2003; 73:263-73. PMID: 12375435.
    View in: PubMed
  29. Bode BP, Fuchs BC, Hurley BP, Conroy JL, Suetterlin JE, Tanabe KK, Rhoads DB, Abcouwer SF, Souba WW. Molecular and functional analysis of glutamine uptake in human hepatoma and liver-derived cells. Am J Physiol Gastrointest Liver Physiol. 2002 Nov; 283(5):G1062-73. PMID: 12381519.
    View in: PubMed
  30. Hurley BP, Thorpe CM, Acheson DW. Shiga toxin translocation across intestinal epithelial cells is enhanced by neutrophil transmigration. Infect Immun. 2001 Oct; 69(10):6148-55. PMID: 11553554; PMCID: PMC98745.
  31. Thorpe CM, Smith WE, Hurley BP, Acheson DW. Shiga toxins induce, superinduce, and stabilize a variety of C-X-C chemokine mRNAs in intestinal epithelial cells, resulting in increased chemokine expression. Infect Immun. 2001 Oct; 69(10):6140-7. PMID: 11553553; PMCID: PMC98744.
  32. Hurley BP, Jacewicz M, Thorpe CM, Lincicome LL, King AJ, Keusch GT, Acheson DW. Shiga toxins 1 and 2 translocate differently across polarized intestinal epithelial cells. Infect Immun. 1999 Dec; 67(12):6670-7. PMID: 10569789; PMCID: PMC97081.
  33. Thorpe CM, Hurley BP, Lincicome LL, Jacewicz MS, Keusch GT, Acheson DW. Shiga toxins stimulate secretion of interleukin-8 from intestinal epithelial cells. Infect Immun. 1999 Nov; 67(11):5985-93. PMID: 10531258; PMCID: PMC96984.
  34. Thorpe CM, Flaumenhaft R, Hurley B, Jacewicz M, Acheson DW, Keusch GT. Shiga toxins do not directly stimulate alpha-granule secretion or enhance aggregation of human platelets. Acta Haematol. 1999; 102(1):51-5. PMID: 10473889.
    View in: PubMed
  35. Fischer CP, Bode BP, Hurley BP, Souba WW. Alterations in oxidative metabolism and glutamine transport support glucose production in the tumor-influenced hepatocyte. J Surg Res. 1997 May; 69(2):379-84. PMID: 9224411.
    View in: PubMed
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