Harvard Catalyst Profiles

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Bryan P. Hurley, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R25DK103579 (HURLEY, BRYAN P) Mar 1, 2015 - Feb 28, 2025
    MGHfC Digestive Disease Summer Research Program
    Role: Principal Investigator
  2. R01AI095338 (HURLEY, BRYAN P) Feb 8, 2012 - May 31, 2023
    The role of hepoxilin A3 in neutrophil breach of the Infected airway mucosa.
    Role: Principal Investigator
  3. K22AI065425 (HURLEY, BRYAN P) Feb 15, 2008 - May 31, 2010
    Eicosanoid Production By Infected Lung Epithelial Cells
    Role: Principal Investigator
  4. F32AI054054 (HURLEY, BRYAN P) Jul 1, 2003 - Jun 30, 2005
    Airway Inflammation: Bacterial Epithelial Interactions
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Samuels TL, Yan K, Patel N, Plehhova K, Coyle C, Hurley BP, Johnston N. Alginates for Protection Against Pepsin-Acid Induced Aerodigestive Epithelial Barrier Disruption. Laryngoscope. 2022 Mar 03. PMID: 35238407.
    Citations:    Fields:    
  2. Yonker LM, Barrios J, Mou H, Hurley BP. Untapped Potential: Therapeutically Targeting Eicosanoids and Endocannabinoids in the Lung. Clin Pharmacol Ther. 2021 07; 110(1):69-81. PMID: 33423293.
    Citations:    Fields:    Translation:HumansAnimals
  3. Yonker LM, Marand A, Muldur S, Hopke A, Leung HM, De La Flor D, Park G, Pinsky H, Guthrie LB, Tearney GJ, Irimia D, Hurley BP. Neutrophil dysfunction in cystic fibrosis. J Cyst Fibros. 2021 11; 20(6):1062-1071. PMID: 33589340.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Gipson KS, Nickerson KP, Drenkard E, Llanos-Chea A, Dogiparthi SK, Lanter BB, Hibbler RM, Yonker LM, Hurley BP, Faherty CS. The Great ESKAPE: Exploring the Crossroads of Bile and Antibiotic Resistance in Bacterial Pathogens. Infect Immun. 2020 09 18; 88(10). PMID: 32661122.
    Citations: 5     Fields:    Translation:HumansCells
  5. Bartley BL, Gardner KJ, Spina S, Hurley BP, Campeau D, Berra L, Yonker LM, Carroll RW. High-Dose Inhaled Nitric Oxide as Adjunct Therapy in Cystic Fibrosis Targeting Burkholderia multivorans. Case Rep Pediatr. 2020; 2020:1536714. PMID: 32685229.
    Citations: 7     
  6. Feldman MB, Dutko RA, Wood MA, Ward RA, Leung HM, Snow RF, De La Flor DJ, Yonker LM, Reedy JL, Tearney GJ, Mou H, Hurley BP, Vyas JM. Aspergillus fumigatus Cell Wall Promotes Apical Airway Epithelial Recruitment of Human Neutrophils. Infect Immun. 2020 01 22; 88(2). PMID: 31767773.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  7. Long SR, Lanter BB, Pazos MA, Mou H, Barrios J, Su CW, Wang ZQ, Walker WA, Hurley BP, Shi HN. Intestinal helminth infection enhances bacteria-induced recruitment of neutrophils to the airspace. Sci Rep. 2019 10 31; 9(1):15703. PMID: 31673002.
    Citations: 4     Fields:    Translation:AnimalsCells
  8. Hurley BP, Jugo RH, Snow RF, Samuels TL, Yonker LM, Mou H, Johnston N, Rosen R. Pepsin Triggers Neutrophil Migration Across Acid Damaged Lung Epithelium. Sci Rep. 2019 09 24; 9(1):13778. PMID: 31551494.
    Citations: 5     Fields:    Translation:HumansCells
  9. Leung HM, Birket SE, Hyun C, Ford TN, Cui D, Solomon GM, Shei RJ, Adewale AT, Lenzie AR, Fernandez-Petty CM, Zheng H, Palermo JH, Cho DY, Woodworth BA, Yonker LM, Hurley BP, Rowe SM, Tearney GJ. Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies. Sci Transl Med. 2019 08 07; 11(504). PMID: 31391319.
    Citations: 11     Fields:    Translation:HumansCellsCTClinical Trials
  10. Lanter BB, Eaton AD, Roper JM, Zimmermann C, Delaney B, Hurley BP. Single versus repeated exposure to human polarized intestinal epithelial monolayers for in vitro protein hazard characterization. Food Chem Toxicol. 2019 Oct; 132:110666. PMID: 31288052.
    Citations:    Fields:    Translation:HumansCells
  11. Levardon H, Yonker LM, Hurley BP, Mou H. Expansion of Airway Basal Cells and Generation of Polarized Epithelium. Bio Protoc. 2018 Jun 05; 8(11). PMID: 30009215.
    Citations: 11     
  12. Drenkard E, Hibbler RM, Gutu DA, Eaton AD, Silverio AL, Ausubel FM, Hurley BP, Yonker LM. Replication of the Ordered, Nonredundant Library of Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutants. J Vis Exp. 2018 05 04; (135). PMID: 29781996.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Zimmermann C, Eaton AD, Lanter BB, Roper J, Hurley BP, Delaney B. Extended exposure duration of cultured intestinal epithelial cell monolayers in characterizing hazardous and non-hazardous proteins. Food Chem Toxicol. 2018 May; 115:451-459. PMID: 29614382.
    Citations:    Fields:    Translation:HumansCells
  14. Yonker LM, Pazos MA, Lanter BB, Mou H, Chu KK, Eaton AD, Bonventre JV, Tearney GJ, Rajagopal J, Hurley BP. Neutrophil-Derived Cytosolic PLA2a Contributes to Bacterial-Induced Neutrophil Transepithelial Migration. J Immunol. 2017 10 15; 199(8):2873-2884. PMID: 28887431.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  15. Yonker LM, Mou H, Chu KK, Pazos MA, Leung H, Cui D, Ryu J, Hibbler RM, Eaton AD, Ford TN, Falck JR, Kinane TB, Tearney GJ, Rajagopal J, Hurley BP. Development of a Primary Human Co-Culture Model of Inflamed Airway Mucosa. Sci Rep. 2017 08 15; 7(1):8182. PMID: 28811631.
    Citations: 23     Fields:    Translation:HumansCells
  16. Pazos MA, Lanter BB, Yonker LM, Eaton AD, Pirzai W, Gronert K, Bonventre JV, Hurley BP. Pseudomonas aeruginosa ExoU augments neutrophil transepithelial migration. PLoS Pathog. 2017 Aug; 13(8):e1006548. PMID: 28771621.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  17. Eaton AD, Zimmermann C, Delaney B, Hurley BP. Primary human polarized small intestinal epithelial barriers respond differently to a hazardous and an innocuous protein. Food Chem Toxicol. 2017 Aug; 106(Pt A):70-77. PMID: 28533127.
    Citations: 7     Fields:    Translation:HumansCells
  18. Chu KK, Kusek ME, Liu L, Som A, Yonker LM, Leung H, Cui D, Ryu J, Eaton AD, Tearney GJ, Hurley BP. Illuminating dynamic neutrophil trans-epithelial migration with micro-optical coherence tomography. Sci Rep. 2017 04 03; 8:45789. PMID: 28368012.
    Citations: 9     Fields:    Translation:HumansCells
  19. Hurley BP, Eaton AD, Zimmermann C, Delaney B. Polarized monolayer cultures of human intestinal epithelial cell lines exposed to intractable proteins - In vitro hazard identification studies. Food Chem Toxicol. 2016 Dec; 98(Pt B):262-268. PMID: 27832974.
    Citations: 1     Fields:    Translation:HumansCells
  20. Chen K, Shanmugam NK, Pazos MA, Hurley BP, Cherayil BJ. Commensal Bacteria-Induced Inflammasome Activation in Mouse and Human Macrophages Is Dependent on Potassium Efflux but Does Not Require Phagocytosis or Bacterial Viability. PLoS One. 2016; 11(8):e0160937. PMID: 27505062.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  21. Johnston N, Ondrey F, Rosen R, Hurley BP, Gould J, Allen J, DelGaudio J, Altman KW. Airway reflux. Ann N Y Acad Sci. 2016 10; 1381(1):5-13. PMID: 27310222.
    Citations: 11     Fields:    Translation:HumansAnimals
  22. Hurley BP, Pirzai W, Eaton AD, Harper M, Roper J, Zimmermann C, Ladics GS, Layton RJ, Delaney B. An experimental platform using human intestinal epithelial cell lines to differentiate between hazardous and non-hazardous proteins. Food Chem Toxicol. 2016 Jun; 92:75-87. PMID: 27060235.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  23. Yonker LM, Cigana C, Hurley BP, Bragonzi A. Host-pathogen interplay in the respiratory environment of cystic fibrosis. J Cyst Fibros. 2015 Jul; 14(4):431-439. PMID: 25800687.
    Citations: 31     Fields:    Translation:Humans
  24. Pazos MA, Pirzai W, Yonker LM, Morisseau C, Gronert K, Hurley BP. Distinct cellular sources of hepoxilin A3 and leukotriene B4 are used to coordinate bacterial-induced neutrophil transepithelial migration. J Immunol. 2015 Feb 01; 194(3):1304-15. PMID: 25548217.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  25. Kusek ME, Pazos MA, Pirzai W, Hurley BP. In vitro coculture assay to assess pathogen induced neutrophil trans-epithelial migration. J Vis Exp. 2014 Jan 06; (83):e50823. PMID: 24430378.
    Citations: 19     Fields:    Translation:HumansCells
  26. Kubala SA, Patil SU, Shreffler WG, Hurley BP. Pathogen induced chemo-attractant hepoxilin A3 drives neutrophils, but not eosinophils across epithelial barriers. Prostaglandins Other Lipid Mediat. 2014 Jan; 108:1-8. PMID: 24315875.
    Citations: 7     Fields:    Translation:HumansCells
  27. Bhowmick R, Maung N, Hurley BP, Ghanem EB, Gronert K, McCormick BA, Leong JM. Systemic disease during Streptococcus pneumoniae acute lung infection requires 12-lipoxygenase-dependent inflammation. J Immunol. 2013 Nov 15; 191(10):5115-23. PMID: 24089193.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  28. Trebicka E, Jacob S, Pirzai W, Hurley BP, Cherayil BJ. Role of antilipopolysaccharide antibodies in serum bactericidal activity against Salmonella enterica serovar Typhimurium in healthy adults and children in the United States. Clin Vaccine Immunol. 2013 Oct; 20(10):1491-8. PMID: 23803904.
    Citations: 24     Fields:    Translation:HumansCells
  29. Tamang DL, Pirzai W, Priebe GP, Traficante DC, Pier GB, Falck JR, Morisseau C, Hammock BD, McCormick BA, Gronert K, Hurley BP. Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers. J Immunol. 2012 Nov 15; 189(10):4960-9. PMID: 23045615.
    Citations: 25     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  30. Hurley BP, Pirzai W, Mumy KL, Gronert K, McCormick BA. Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Feb; 300(2):L286-94. PMID: 21097525.
    Citations: 20     Fields:    Translation:HumansCells
  31. Hurley BP, Goodman AL, Mumy KL, Murphy P, Lory S, McCormick BA. The two-component sensor response regulator RoxS/RoxR plays a role in Pseudomonas aeruginosa interactions with airway epithelial cells. Microbes Infect. 2010 Mar; 12(3):190-8. PMID: 19961952.
    Citations: 10     Fields:    Translation:HumansCells
  32. Mumy KL, Bien JD, Pazos MA, Gronert K, Hurley BP, McCormick BA. Distinct isoforms of phospholipase A2 mediate the ability of Salmonella enterica serotype typhimurium and Shigella flexneri to induce the transepithelial migration of neutrophils. Infect Immun. 2008 Aug; 76(8):3614-27. PMID: 18505810.
    Citations: 27     Fields:    Translation:HumansCells
  33. Hurley BP, McCormick BA. Multiple roles of phospholipase A2 during lung infection and inflammation. Infect Immun. 2008 Jun; 76(6):2259-72. PMID: 18411286.
    Citations: 23     Fields:    Translation:HumansAnimals
  34. Hurley BP, Sin A, McCormick BA. Adhesion molecules involved in hepoxilin A3-mediated neutrophil transepithelial migration. Clin Exp Immunol. 2008 Feb; 151(2):297-305. PMID: 18005361.
    Citations: 19     Fields:    Translation:HumansCells
  35. Köhler H, Sakaguchi T, Hurley BP, Kase BA, Kase BJ, Reinecker HC, McCormick BA. Salmonella enterica serovar Typhimurium regulates intercellular junction proteins and facilitates transepithelial neutrophil and bacterial passage. Am J Physiol Gastrointest Liver Physiol. 2007 Jul; 293(1):G178-87. PMID: 17615177.
    Citations: 56     Fields:    Translation:HumansCells
  36. Hurley BP, Williams NL, McCormick BA. Involvement of phospholipase A2 in Pseudomonas aeruginosa-mediated PMN transepithelial migration. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L703-L709. PMID: 16272174.
    Citations: 19     Fields:    Translation:HumansCells
  37. Hurley BP, Siccardi D, Mrsny RJ, McCormick BA. Polymorphonuclear cell transmigration induced by Pseudomonas aeruginosa requires the eicosanoid hepoxilin A3. J Immunol. 2004 Nov 01; 173(9):5712-20. PMID: 15494523.
    Citations: 42     Fields:    Translation:HumansCells
  38. Hurley BP, McCormick BA. Intestinal epithelial defense systems protect against bacterial threats. Curr Gastroenterol Rep. 2004 Oct; 6(5):355-61. PMID: 15341710.
    Citations: 4     Fields:    Translation:Humans
  39. Spacek LA, Hurley BP, Acheson DW, Granok A, Currie A, Doing K, Sears CL. Shiga toxin-producing Escherichia coli as a possible etiological agent of chronic diarrhea. Clin Infect Dis. 2004 Sep 01; 39(5):e46-8. PMID: 15356801.
    Citations: 1     Fields:    Translation:HumansCells
  40. Mrsny RJ, Gewirtz AT, Siccardi D, Savidge T, Hurley BP, Madara JL, McCormick BA. Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7421-6. PMID: 15123795.
    Citations: 84     Fields:    Translation:HumansCells
  41. Hurley BP, McCormick BA. Translating tissue culture results into animal models: the case of Salmonella typhimurium. Trends Microbiol. 2003 Dec; 11(12):562-9. PMID: 14659688.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  42. Thorpe CM, Hurley BP, Acheson DW. Shiga toxin interactions with the intestinal epithelium. Methods Mol Med. 2003; 73:263-73. PMID: 12375435.
    Citations: 3     Fields:    Translation:HumansAnimals
  43. Bode BP, Fuchs BC, Hurley BP, Conroy JL, Suetterlin JE, Tanabe KK, Rhoads DB, Abcouwer SF, Souba WW. Molecular and functional analysis of glutamine uptake in human hepatoma and liver-derived cells. Am J Physiol Gastrointest Liver Physiol. 2002 Nov; 283(5):G1062-73. PMID: 12381519.
    Citations: 33     Fields:    Translation:HumansCells
  44. Hurley BP, Thorpe CM, Acheson DW. Shiga toxin translocation across intestinal epithelial cells is enhanced by neutrophil transmigration. Infect Immun. 2001 Oct; 69(10):6148-55. PMID: 11553554.
    Citations: 55     Fields:    Translation:HumansCells
  45. Thorpe CM, Smith WE, Hurley BP, Acheson DW. Shiga toxins induce, superinduce, and stabilize a variety of C-X-C chemokine mRNAs in intestinal epithelial cells, resulting in increased chemokine expression. Infect Immun. 2001 Oct; 69(10):6140-7. PMID: 11553553.
    Citations: 59     Fields:    Translation:HumansCells
  46. Hurley BP, Jacewicz M, Thorpe CM, Lincicome LL, King AJ, Keusch GT, Acheson DW. Shiga toxins 1 and 2 translocate differently across polarized intestinal epithelial cells. Infect Immun. 1999 Dec; 67(12):6670-7. PMID: 10569789.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  47. Thorpe CM, Hurley BP, Lincicome LL, Jacewicz MS, Keusch GT, Acheson DW. Shiga toxins stimulate secretion of interleukin-8 from intestinal epithelial cells. Infect Immun. 1999 Nov; 67(11):5985-93. PMID: 10531258.
    Citations: 69     Fields:    Translation:HumansCells
  48. Thorpe CM, Flaumenhaft R, Hurley B, Jacewicz M, Acheson DW, Keusch GT. Shiga toxins do not directly stimulate alpha-granule secretion or enhance aggregation of human platelets. Acta Haematol. 1999; 102(1):51-5. PMID: 10473889.
    Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
  49. Fischer CP, Bode BP, Hurley BP, Souba WW. Alterations in oxidative metabolism and glutamine transport support glucose production in the tumor-influenced hepatocyte. J Surg Res. 1997 May; 69(2):379-84. PMID: 9224411.
    Citations: 2     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.