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profileRonglih Liao, PH.D.

TitleProfessor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Cardiovascular Division/Medicine, NRB 431
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/525-4854
Fax617/525-4868
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R13HL138968     (LIAO, RONGLIH)Jul 1, 2017 - Jun 30, 2018
NIH/NHLBI
AHA Basic Cardiovascular Sciences Council (BCVS), 2017 Scientific Sessions: Pathways to Cardiovascular Therapeutics
Role: Principal Investigator

R01HL132511     (LIAO, RONGLIH)Feb 15, 2017 - Jan 31, 2021
NIH/NHLBI
Mulan: a novel regulator of mitochondrial dynamics, mitophagy and heart function
Role: Principal Investigator

R01HL128135     (LIAO, RONGLIH)Apr 1, 2015 - Jan 31, 2019
NIH/NHLBI
Metabolic underpinnings of AL amyloid cardiomyopathy
Role: Principal Investigator

R01HL099073     (LIAO, RONGLIH)Aug 1, 2010 - Apr 30, 2014
NIH/NHLBI
3D combinatorial microenvironments for effective cell based therapy
Role: Co-Principal Investigator

R01HL093148     (LIAO, RONGLIH)Jul 21, 2008 - Dec 30, 2013
NIH/NHLBI
Role of Abcg2/Bcrp1 in Cardiac Side Population Cells
Role: Principal Investigator
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eagle-i@hms.harvard.edu.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ge JT, Li YY, Tian J, Liao RZ, Dong H. Synthesis of Deoxyglycosides by Desulfurization under UV Light. J Org Chem. 2017 Jul 07; 82(13):7008-7014. PMID: 28598624.
    View in: PubMed
  2. Zucker IH, Lindsey ML, Delmar M, De Windt LJ, Des Rosiers C, Diz DI, Hester RL, Jones SP, Kanagy NL, Kitakaze M, Liao R, Lopaschuk GD, Patel KP, Recchia FA, Sadoshima J, Shah AM, Ungvari Z, Benjamin IJ, Blaustein MP, Charkoudian N, Efimov IR, Gutterman D, Kass DA, Liao Y, O'Leary DS, Ripplinger CM, Wolin MS. Why publish in the American Journal of Physiology-Heart and Circulatory Physiology? Am J Physiol Heart Circ Physiol. 2017 Aug 01; 313(2):H221-H223. PMID: 28626081.
    View in: PubMed
  3. Liao R, Ward JE. Amyloid Cardiomyopathy: Disease on the Rise. Circ Res. 2017 Jun 09; 120(12):1865-1867. PMID: 28596171.
    View in: PubMed
  4. Qian F, Huang C, Lin YD, Ivanovskaya AN, O'Hara TJ, Booth RH, Creek CJ, Enright HA, Soscia DA, Belle AM, Liao R, Lightstone FC, Kulp KS, Wheeler EK. Simultaneous electrical recording of cardiac electrophysiology and contraction on chip. Lab Chip. 2017 May 16; 17(10):1732-1739. PMID: 28448074.
    View in: PubMed
  5. Wei WJ, Siegbahn PE, Liao RZ. Theoretical Study of the Mechanism of the Nonheme Iron Enzyme EgtB. Inorg Chem. 2017 Mar 20; 56(6):3589-3599. PMID: 28277674.
    View in: PubMed
  6. Li YY, Ye K, Siegbahn PE, Liao RZ. Mechanism of Water Oxidation Catalyzed by a Mononuclear Manganese Complex. ChemSusChem. 2017 Mar 09; 10(5):903-911. PMID: 27925413.
    View in: PubMed
  7. Chen HH, Yuan H, Cho H, Feng Y, Ngoy S, Kumar AT, Liao R, Chao W, Josephson L, Sosnovik DE. Theranostic Nucleic Acid Binding Nanoprobe Exerts Anti-inflammatory and Cytoprotective Effects in Ischemic Injury. Theranostics. 2017; 7(4):814-825. PMID: 28382156.
    View in: PubMed
  8. Sarosiek KA, Fraser C, Muthalagu N, Bhola PD, Chang W, McBrayer SK, Cantlon A, Fisch S, Golomb-Mello G, Ryan JA, Deng J, Jian B, Corbett C, Goldenberg M, Madsen JR, Liao R, Walsh D, Sedivy J, Murphy DJ, Carrasco DR, Robinson S, Moslehi J, Letai A. Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics. Cancer Cell. 2017 Jan 09; 31(1):142-156. PMID: 28017613.
    View in: PubMed
  9. Falk RH, Alexander KM, Liao R, Dorbala S. AL (Light-Chain) Cardiac Amyloidosis: A Review of Diagnosis and Therapy. J Am Coll Cardiol. 2016 Sep 20; 68(12):1323-41. PMID: 27634125.
    View in: PubMed
  10. Liao RZ, Chen SL, Siegbahn PE. Unraveling the Mechanism and Regioselectivity of the B12-Dependent Reductive Dehalogenase PceA. Chemistry. 2016 Aug 22; 22(35):12391-9. PMID: 27459105.
    View in: PubMed
  11. Sapp V, Jain M, Liao R. Viewing Extrinsic Proteotoxic Stress Through the Lens of Amyloid Cardiomyopathy. Physiology (Bethesda). 2016 07; 31(4):294-9. PMID: 27252164.
    View in: PubMed
  12. Zhang S, Chen Z, Qin S, Lou C, Senan AM, Liao RZ, Yin G. Non-redox metal ion promoted oxidative coupling of indoles with olefins by the palladium(ii) acetate catalyst through dioxygen activation: experimental results with DFT calculations. Org Biomol Chem. 2016 Apr 26; 14(17):4146-57. PMID: 27075840.
    View in: PubMed
  13. Kuster GM, Liao R. Fortune Favors the Prepared: Safety and Efficacy of Allogeneic Hypoxia Preconditioned Mesenchymal Stromal Cells in Primates. Circ Res. 2016 Mar 18; 118(6):908-10. PMID: 26987910.
    View in: PubMed
  14. Fisch S, Liao R, Hsiao LL, Lu T. Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats. J Vis Exp. 2016 Mar 11; (109). PMID: 27022768; PMCID: PMC4828235.
  15. Liao RZ, Siegbahn PE. Phosphate Hydrolysis by the Fe2-Ca3-Dependent Alkaline Phosphatase PhoX: Mechanistic Insights from DFT calculations. Inorg Chem. 2015 Dec 21; 54(24):11941-7. PMID: 26651528.
    View in: PubMed
  16. Yang Y, Cheng HW, Qiu Y, Dupee D, Noonan M, Lin YD, Fisch S, Unno K, Sereti KI, Liao R. MicroRNA-34a Plays a Key Role in Cardiac Repair and Regeneration Following Myocardial Infarction. Circ Res. 2015 Aug 14; 117(5):450-9. PMID: 26082557; PMCID: PMC4769861.
  17. Liao RZ, Wang M, Sun L, Siegbahn PE. The mechanism of hydrogen evolution in Cu(bztpen)-catalysed water reduction: a DFT study. Dalton Trans. 2015 Jun 07; 44(21):9736-9. PMID: 25928325.
    View in: PubMed
  18. Guan J, Mishra S, Qiu Y, Shi J, Trudeau K, Las G, Liesa M, Shirihai OS, Connors LH, Seldin DC, Falk RH, MacRae CA, Liao R. Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity. EMBO Mol Med. 2015 May; 7(5):688. PMID: 25940533; PMCID: PMC4492824.
  19. Chang WT, Fisch S, Chen M, Qiu Y, Cheng S, Liao R. Ultrasound based assessment of coronary artery flow and coronary flow reserve using the pressure overload model in mice. J Vis Exp. 2015 Apr 13; (98):e52598. PMID: 25938185.
    View in: PubMed
  20. Liao RZ, Siegbahn PEM. Mechanism and selectivity of the dinuclear iron benzoyl-coenzyme A epoxidase BoxB. Chem Sci. 2015 May 01; 6(5):2754-2764. PMID: 28706665.
    View in: PubMed
  21. Qiu Y, Bayomy AF, Gomez MV, Bauer M, Du P, Yang Y, Zhang X, Liao R. A role for matrix stiffness in the regulation of cardiac side population cell function. Am J Physiol Heart Circ Physiol. 2015 May 01; 308(9):H990-7. PMID: 25724498; PMCID: PMC4551131.
  22. Guan J, Mishra S, Qiu Y, Shi J, Trudeau K, Las G, Liesa M, Shirihai OS, Connors LH, Seldin DC, Falk RH, MacRae CA, Liao R. Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity. EMBO Mol Med. 2014 Nov; 6(11):1493-507. PMID: 25319546; PMCID: PMC4237473.
  23. Liao R. Worming along in amyloid cardiotoxicity. Blood. 2014 Jun 05; 123(23):3525-6. PMID: 24904094; PMCID: PMC4047492.
  24. Hiremath P, Bauer M, Aguirre AD, Cheng HW, Unno K, Patel RB, Harvey BW, Chang WT, Groarke JD, Liao R, Cheng S. Identifying early changes in myocardial microstructure in hypertensive heart disease. PLoS One. 2014; 9(5):e97424. PMID: 24831515; PMCID: PMC4022613.
  25. Goichberg P, Chang J, Liao R, Leri A. Cardiac stem cells: biology and clinical applications. Antioxid Redox Signal. 2014 Nov 10; 21(14):2002-17. PMID: 24597850; PMCID: PMC4208604.
  26. Hilgendorf I, Gerhardt LM, Tan TC, Winter C, Holderried TA, Chousterman BG, Iwamoto Y, Liao R, Zirlik A, Scherer-Crosbie M, Hedrick CC, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium. Circ Res. 2014 May 09; 114(10):1611-22. PMID: 24625784; PMCID: PMC4017349.
  27. Sosnovik DE, Mekkaoui C, Huang S, Chen HH, Dai G, Stoeck CT, Ngoy S, Guan J, Wang R, Kostis WJ, Jackowski MP, Wedeen VJ, Kozerke S, Liao R. Microstructural impact of ischemia and bone marrow-derived cell therapy revealed with diffusion tensor magnetic resonance imaging tractography of the heart in vivo. Circulation. 2014 Apr 29; 129(17):1731-41. PMID: 24619466; PMCID: PMC4034455.
  28. Jain M, Ngoy S, Sheth SA, Swanson RA, Rhee EP, Liao R, Clish CB, Mootha VK, Nilsson R. A systematic survey of lipids across mouse tissues. Am J Physiol Endocrinol Metab. 2014 Apr 15; 306(8):E854-68. PMID: 24518676; PMCID: PMC3989739.
  29. Hsieh HY, Camci-Unal G, Huang TW, Liao R, Chen TJ, Paul A, Tseng FG, Khademhosseini A. Gradient static-strain stimulation in a microfluidic chip for 3D cellular alignment. Lab Chip. 2014 Feb 07; 14(3):482-93. PMID: 24253194; PMCID: PMC4040516.
  30. Cheng HW, Fisch S, Cheng S, Bauer M, Ngoy S, Qiu Y, Guan J, Mishra S, Mbah C, Liao R. Assessment of right ventricular structure and function in mouse model of pulmonary artery constriction by transthoracic echocardiography. J Vis Exp. 2014 Feb 03; (84):e51041. PMID: 24513696; PMCID: PMC4397999.
  31. Hiremath P, Bauer M, Cheng HW, Unno K, Liao R, Cheng S. Ultrasonic assessment of myocardial microstructure. J Vis Exp. 2014 Jan 14; (83):e50850. PMID: 24458028; PMCID: PMC4089473.
  32. Cha C, Oh J, Kim K, Qiu Y, Joh M, Shin SR, Wang X, Camci-Unal G, Wan KT, Liao R, Khademhosseini A. Microfluidics-assisted fabrication of gelatin-silica core-shell microgels for injectable tissue constructs. Biomacromolecules. 2014 Jan 13; 15(1):283-90. PMID: 24344625; PMCID: PMC3922064.
  33. Pfister O, Della Verde G, Liao R, Kuster GM. Regenerative therapy for cardiovascular disease. Transl Res. 2014 Apr; 163(4):307-20. PMID: 24378637.
    View in: PubMed
  34. Pfister O, Lorenz V, Oikonomopoulos A, Xu L, Häuselmann SP, Mbah C, Kaufmann BA, Liao R, Wodnar-Filipowicz A, Kuster GM. FLT3 activation improves post-myocardial infarction remodeling involving a cytoprotective effect on cardiomyocytes. J Am Coll Cardiol. 2014 Mar 18; 63(10):1011-9. PMID: 24184252.
    View in: PubMed
  35. Tsukamoto K, Mani DR, Shi J, Zhang S, Haagensen DE, Otsuka F, Guan J, Smith JD, Weng W, Liao R, Kolodgie FD, Virmani R, Krieger M. Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):17023-8. PMID: 24082102; PMCID: PMC3801016.
  36. Icli B, Wara AK, Moslehi J, Sun X, Plovie E, Cahill M, Marchini JF, Schissler A, Padera RF, Shi J, Cheng HW, Raghuram S, Arany Z, Liao R, Croce K, MacRae C, Feinberg MW. MicroRNA-26a regulates pathological and physiological angiogenesis by targeting BMP/SMAD1 signaling. Circ Res. 2013 Nov 08; 113(11):1231-41. PMID: 24047927; PMCID: PMC4068743.
  37. Guan J, Mishra S, Shi J, Plovie E, Qiu Y, Cao X, Gianni D, Jiang B, Del Monte F, Connors LH, Seldin DC, Lavatelli F, Rognoni P, Palladini G, Merlini G, Falk RH, Semigran MJ, Dec GW, Macrae CA, Liao R. Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity. Basic Res Cardiol. 2013 Sep; 108(5):378. PMID: 23982491; PMCID: PMC3914405.
  38. Mishra S, Guan J, Plovie E, Seldin DC, Connors LH, Merlini G, Falk RH, MacRae CA, Liao R. Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish. Am J Physiol Heart Circ Physiol. 2013 Jul 01; 305(1):H95-103. PMID: 23624626; PMCID: PMC3727100.
  39. Chen J, Huang ZP, Seok HY, Ding J, Kataoka M, Zhang Z, Hu X, Wang G, Lin Z, Wang S, Pu WT, Liao R, Wang DZ. mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circ Res. 2013 Jun 07; 112(12):1557-66. PMID: 23575307; PMCID: PMC3756475.
  40. Bauer M, Cheng S, Unno K, Lin FC, Liao R. Regional cardiac dysfunction and dyssynchrony in a murine model of afterload stress. PLoS One. 2013; 8(4):e59915. PMID: 23560059; PMCID: PMC3613376.
  41. Chen HH, Mekkaoui C, Cho H, Ngoy S, Marinelli B, Waterman P, Nahrendorf M, Liao R, Josephson L, Sosnovik DE. Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo. Circ Cardiovasc Imaging. 2013 May 01; 6(3):441-7. PMID: 23537953; PMCID: PMC3805276.
  42. Shi J, Jiang B, Qiu Y, Guan J, Jain M, Cao X, Bauer M, Su L, Burkly LC, Leone TC, Kelly DP, Liao R. PGC1a plays a critical role in TWEAK-induced cardiac dysfunction. PLoS One. 2013; 8(1):e54054. PMID: 23342071; PMCID: PMC3546975.
  43. Sereti KI, Oikonomopoulos A, Unno K, Liao R. Methods to study the proliferation and differentiation of cardiac side population (CSP) cells. Methods Mol Biol. 2013; 1036:95-106. PMID: 23807790.
    View in: PubMed
  44. Bauer M, Kang L, Qiu Y, Wu J, Peng M, Chen HH, Camci-Unal G, Bayomy AF, Sosnovik DE, Khademhosseini A, Liao R. Adult cardiac progenitor cell aggregates exhibit survival benefit both in vitro and in vivo. PLoS One. 2012; 7(11):e50491. PMID: 23226295; PMCID: PMC3511575.
  45. Sereti KI, Oikonomopoulos A, Unno K, Cao X, Qiu Y, Liao R. ATP-binding cassette G-subfamily transporter 2 regulates cell cycle progression and asymmetric division in mouse cardiac side population progenitor cells. Circ Res. 2013 Jan 04; 112(1):27-34. PMID: 23136123; PMCID: PMC3959170.
  46. Bayomy AF, Bauer M, Qiu Y, Liao R. Regeneration in heart disease-Is ECM the key? Life Sci. 2012 Oct 29; 91(17-18):823-7. PMID: 22982346; PMCID: PMC4013147.
  47. Bauer M, Kim K, Qiu Y, Calpe B, Khademhosseini A, Liao R, Wheeldon I. Spot identification and quality control in cell-based microarrays. ACS Comb Sci. 2012 Aug 13; 14(8):471-7. PMID: 22850537; PMCID: PMC3495599.
  48. Lee LS, Ghanta RK, Mokashi SA, Coelho-Filho O, Kwong RY, Kwon M, Guan J, Liao R, Chen FY. Optimized ventricular restraint therapy: adjustable restraint is superior to standard restraint in an ovine model of ischemic cardiomyopathy. J Thorac Cardiovasc Surg. 2013 Mar; 145(3):824-31. PMID: 22698557; PMCID: PMC3954527.
  49. Liao R, Podesser BK, Lim CC. The continuing evolution of the Langendorff and ejecting murine heart: new advances in cardiac phenotyping. Am J Physiol Heart Circ Physiol. 2012 Jul 15; 303(2):H156-67. PMID: 22636675; PMCID: PMC3404701.
  50. Unno K, Jain M, Liao R. Cardiac side population cells: moving toward the center stage in cardiac regeneration. Circ Res. 2012 May 11; 110(10):1355-63. PMID: 22581921; PMCID: PMC3412159.
  51. Kim M, Shen M, Ngoy S, Karamanlidis G, Liao R, Tian R. AMPK isoform expression in the normal and failing hearts. J Mol Cell Cardiol. 2012 May; 52(5):1066-73. PMID: 22314372; PMCID: PMC3327798.
  52. Wang X, Cui L, Joseph J, Jiang B, Pimental D, Handy DE, Liao R, Loscalzo J. Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress. J Mol Cell Cardiol. 2012 Mar; 52(3):753-60. PMID: 22227328; PMCID: PMC3294144.
  53. Guan J, Mishra S, Falk RH, Liao R. Current perspectives on cardiac amyloidosis. Am J Physiol Heart Circ Physiol. 2012 Feb 01; 302(3):H544-52. PMID: 22058156; PMCID: PMC3353775.
  54. Oikonomopoulos A, Sereti KI, Conyers F, Bauer M, Liao A, Guan J, Crapps D, Han JK, Dong H, Bayomy AF, Fine GC, Westerman K, Biechele TL, Moon RT, Force T, Liao R. Wnt signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3. Circ Res. 2011 Dec 09; 109(12):1363-74. PMID: 22034491; PMCID: PMC3384997.
  55. Ward JE, Ren R, Toraldo G, Soohoo P, Guan J, O'Hara C, Jasuja R, Trinkaus-Randall V, Liao R, Connors LH, Seldin DC. Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis. Blood. 2011 Dec 15; 118(25):6610-7. PMID: 21998211; PMCID: PMC3242721.
  56. Dvir T, Bauer M, Schroeder A, Tsui JH, Anderson DG, Langer R, Liao R, Kohane DS. Nanoparticles targeting the infarcted heart. Nano Lett. 2011 Oct 12; 11(10):4411-4. PMID: 21899318; PMCID: PMC3192253.
  57. Huang S, Chen HH, Yuan H, Dai G, Schuhle DT, Mekkaoui C, Ngoy S, Liao R, Caravan P, Josephson L, Sosnovik DE. Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium. Circ Cardiovasc Imaging. 2011 Nov; 4(6):729-37. PMID: 21836081; PMCID: PMC3370828.
  58. Kajstura J, Rota M, Hall SR, Hosoda T, D'Amario D, Sanada F, Zheng H, Ogórek B, Rondon-Clavo C, Ferreira-Martins J, Matsuda A, Arranto C, Goichberg P, Giordano G, Haley KJ, Bardelli S, Rayatzadeh H, Liu X, Quaini F, Liao R, Leri A, Perrella MA, Loscalzo J, Anversa P. Evidence for human lung stem cells. N Engl J Med. 2011 May 12; 364(19):1795-806. PMID: 21561345; PMCID: PMC3197695.
  59. Bauer M, Cheng S, Jain M, Ngoy S, Theodoropoulos C, Trujillo A, Lin FC, Liao R. Echocardiographic speckle-tracking based strain imaging for rapid cardiovascular phenotyping in mice. Circ Res. 2011 Apr 15; 108(8):908-16. PMID: 21372284; PMCID: PMC3376717.
  60. Li Y, Hiroi Y, Ngoy S, Okamoto R, Noma K, Wang CY, Wang HW, Zhou Q, Radtke F, Liao R, Liao JK. Notch1 in bone marrow-derived cells mediates cardiac repair after myocardial infarction. Circulation. 2011 Mar 01; 123(8):866-76. PMID: 21321153; PMCID: PMC3488350.
  61. Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 2011 Feb 17; 470(7334):359-65. PMID: 21307849; PMCID: PMC3741661.
  62. Mokashi SA, Guan J, Wang D, Tchantchaleishvili V, Brigham M, Lipsitz S, Lee LS, Schmitto JD, Bolman RM, Khademhosseini A, Liao R, Chen FY. Preventing cardiac remodeling: the combination of cell-based therapy and cardiac support therapy preserves left ventricular function in rodent model of myocardial ischemia. J Thorac Cardiovasc Surg. 2010 Dec; 140(6):1374-80. PMID: 21078426.
    View in: PubMed
  63. Moslehi J, Minamishima YA, Shi J, Neuberg D, Charytan DM, Padera RF, Signoretti S, Liao R, Kaelin WG. Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy. Circulation. 2010 Sep 07; 122(10):1004-16. PMID: 20733101; PMCID: PMC2971656.
  64. Urbanek K, Cabral-da-Silva MC, Ide-Iwata N, Maestroni S, Delucchi F, Zheng H, Ferreira-Martins J, Ogórek B, D'Amario D, Bauer M, Zerbini G, Rota M, Hosoda T, Liao R, Anversa P, Kajstura J, Leri A. Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart. Circ Res. 2010 Aug 06; 107(3):429-41. PMID: 20558824; PMCID: PMC2919068.
  65. Jiang B, Liao R. The paradoxical role of inflammation in cardiac repair and regeneration. J Cardiovasc Transl Res. 2010 Aug; 3(4):410-6. PMID: 20559773.
    View in: PubMed
  66. Shi J, Guan J, Jiang B, Brenner DA, Del Monte F, Ward JE, Connors LH, Sawyer DB, Semigran MJ, Macgillivray TE, Seldin DC, Falk R, Liao R. Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4188-93. PMID: 20150510; PMCID: PMC2840082.
  67. Kuster GM, Lancel S, Zhang J, Communal C, Trucillo MP, Lim CC, Pfister O, Weinberg EO, Cohen RA, Liao R, Siwik DA, Colucci WS. Redox-mediated reciprocal regulation of SERCA and Na+-Ca2+ exchanger contributes to sarcoplasmic reticulum Ca2+ depletion in cardiac myocytes. Free Radic Biol Med. 2010 May 01; 48(9):1182-7. PMID: 20132882; PMCID: PMC2847633.
  68. Pfister O, Oikonomopoulos A, Sereti KI, Liao R. Isolation of resident cardiac progenitor cells by Hoechst 33342 staining. Methods Mol Biol. 2010; 660:53-63. PMID: 20680812.
    View in: PubMed
  69. Mouquet F, Rousseau D, Domergue-Dupont V, Grynberg A, Liao R. Effects of trimetazidine, a partial inhibitor of fatty acid oxidation, on ventricular function and survival after myocardial infarction and reperfusion in the rat. Fundam Clin Pharmacol. 2010 Aug; 24(4):469-76. PMID: 20030737.
    View in: PubMed
  70. Yu M, Liu Y, Xiang F, Li Y, Cullen D, Liao R, Beyer RP, Bammler TK, Chin MT. CHF1/Hey2 promotes physiological hypertrophy in response to pressure overload through selective repression and activation of specific transcriptional pathways. OMICS. 2009 Dec; 13(6):501-11. PMID: 20001863; PMCID: PMC3145963.
  71. Lim CC, Bryan NS, Jain M, Garcia-Saura MF, Fernandez BO, Sawyer DB, Handy DE, Loscalzo J, Feelisch M, Liao R. Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms. Am J Physiol Heart Circ Physiol. 2009 Dec; 297(6):H2144-53. PMID: 19801492; PMCID: PMC2793140.
  72. Sartoretto JL, Jin BY, Bauer M, Gertler FB, Liao R, Michel T. Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart. Am J Physiol Heart Circ Physiol. 2009 Nov; 297(5):H1697-710. PMID: 19734360; PMCID: PMC2781375.
  73. Minamishima YA, Moslehi J, Padera RF, Bronson RT, Liao R, Kaelin WG. A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo. Mol Cell Biol. 2009 Nov; 29(21):5729-41. PMID: 19720742; PMCID: PMC2772748.
  74. Rao PK, Toyama Y, Chiang HR, Gupta S, Bauer M, Medvid R, Reinhardt F, Liao R, Krieger M, Jaenisch R, Lodish HF, Blelloch R. Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res. 2009 Sep 11; 105(6):585-94. PMID: 19679836; PMCID: PMC2828903.
  75. Qiu Y, Liao R, Zhang X. Intervention of cardiomyocyte death based on real-time monitoring of cell adhesion through impedance sensing. Biosens Bioelectron. 2009 Sep 15; 25(1):147-53. PMID: 19615884.
    View in: PubMed
  76. Yan J, Young ME, Cui L, Lopaschuk GD, Liao R, Tian R. Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity. Circulation. 2009 Jun 02; 119(21):2818-28. PMID: 19451348; PMCID: PMC2765220.
  77. Park HJ, Zhang Y, Du C, Welzig CM, Madias C, Aronovitz MJ, Georgescu SP, Naggar I, Wang B, Kim YB, Blaustein RO, Karas RH, Liao R, Mathews CE, Galper JB. Role of SREBP-1 in the development of parasympathetic dysfunction in the hearts of type 1 diabetic Akita mice. Circ Res. 2009 Jul 31; 105(3):287-94. PMID: 19423844; PMCID: PMC2730600.
  78. Jain M, Jakubowski A, Cui L, Shi J, Su L, Bauer M, Guan J, Lim CC, Naito Y, Thompson JS, Sam F, Ambrose C, Parr M, Crowell T, Lincecum JM, Wang MZ, Hsu YM, Zheng TS, Michaelson JS, Liao R, Burkly LC. A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure. Circulation. 2009 Apr 21; 119(15):2058-68. PMID: 19349318; PMCID: PMC2924152.
  79. Qiu Y, Liao R, Zhang X. Impedance-based monitoring of ongoing cardiomyocyte death induced by tumor necrosis factor-alpha. Biophys J. 2009 Mar 04; 96(5):1985-91. PMID: 19254558; PMCID: PMC2717358.
  80. Sun JG, Wang Y, Chen ZT, Zhuo WL, Zhu B, Liao RX, Zhang SX. Detection of lymphangiogenesis in non-small cell lung cancer and its prognostic value. J Exp Clin Cancer Res. 2009 Feb 16; 28:21. PMID: 19216806; PMCID: PMC2647904.
  81. Qiu Y, Liao R, Zhang X. Intervention of cardiomyocyte death based on the impedance-sensing technique of monitoring cell adhesion. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:4457-60. PMID: 19964632.
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  82. Liu X, Ramjiganesh T, Chen YH, Chung SW, Hall SR, Schissel SL, Padera RF, Liao R, Ackerman KG, Kajstura J, Leri A, Anversa P, Yet SF, Layne MD, Perrella MA. Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice. Circulation. 2009 Jan 20; 119(2):261-8. PMID: 19118250; PMCID: PMC2630246.
  83. Pfister O, Oikonomopoulos A, Sereti KI, Sohn RL, Cullen D, Fine GC, Mouquet F, Westerman K, Liao R. Role of the ATP-binding cassette transporter Abcg2 in the phenotype and function of cardiac side population cells. Circ Res. 2008 Oct 10; 103(8):825-35. PMID: 18787193; PMCID: PMC3115759.
  84. Podesser BK, Bauer M, Liao R. Evolving cell-based therapies for heart failure patients. Curr Treat Options Cardiovasc Med. 2008 Aug; 10(4):358-67. PMID: 18647591.
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  85. Fine GC, Liao R, Sohn RL. Cell therapy for cardiac repair. Panminerva Med. 2008 Jun; 50(2):129-37. PMID: 18607336.
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  86. Pfister O, Liao R. Pump to survive: novel cytoprotective strategies for cardiac progenitor cells. Circ Res. 2008 May 09; 102(9):998-1001. PMID: 18467637; PMCID: PMC2924141.
  87. Kontaridis MI, Yang W, Bence KK, Cullen D, Wang B, Bodyak N, Ke Q, Hinek A, Kang PM, Liao R, Neel BG. Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways. Circulation. 2008 Mar 18; 117(11):1423-35. PMID: 18316486; PMCID: PMC2394674.
  88. Qiu Y, Liao R, Zhang X. Real-time monitoring primary cardiomyocyte adhesion based on electrochemical impedance spectroscopy and electrical cell-substrate impedance sensing. Anal Chem. 2008 Feb 15; 80(4):990-6. PMID: 18215019.
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  89. Lim CC, Yang H, Yang M, Wang CK, Shi J, Berg EA, Pimentel DR, Gwathmey JK, Hajjar RJ, Helmes M, Costello CE, Huo S, Liao R. A novel mutant cardiac troponin C disrupts molecular motions critical for calcium binding affinity and cardiomyocyte contractility. Biophys J. 2008 May 01; 94(9):3577-89. PMID: 18212018; PMCID: PMC2292379.
  90. Zhu M, Gach AA, Liu G, Xu X, Lim CC, Zhang JX, Mao L, Chuprun K, Koch WJ, Liao R, Koren G, Blaxall BC, Mende U. Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1335-47. PMID: 18192223.
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  91. Park HJ, Georgescu SP, Du C, Madias C, Aronovitz MJ, Welzig CM, Wang B, Begley U, Zhang Y, Blaustein RO, Patten RD, Karas RH, Van Tol HH, Osborne TF, Shimano H, Liao R, Link MS, Galper JB. Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP. J Clin Invest. 2008 Jan; 118(1):259-71. PMID: 18060044; PMCID: PMC2104475.
  92. Liao R, Force T. Not all hypertrophy is created equal. Circ Res. 2007 Nov 26; 101(11):1069-72. PMID: 18040021.
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  93. Zhao Y, Lim CC, Sawyer DB, Liao R, Zhang X. Simultaneous orientation and cellular force measurements in adult cardiac myocytes using three-dimensional polymeric microstructures. Cell Motil Cytoskeleton. 2007 Sep; 64(9):718-25. PMID: 17615571.
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  94. Luptak I, Yan J, Cui L, Jain M, Liao R, Tian R. Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stress. Circulation. 2007 Aug 21; 116(8):901-9. PMID: 17679614.
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  95. Liao R, Pfister O, Jain M, Mouquet F. The bone marrow--cardiac axis of myocardial regeneration. Prog Cardiovasc Dis. 2007 Jul-Aug; 50(1):18-30. PMID: 17631435; PMCID: PMC2096729.
  96. Sohn RL, Jain M, Liao R. Adult stem cells and heart regeneration. Expert Rev Cardiovasc Ther. 2007 May; 5(3):507-17. PMID: 17489674.
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  97. Fisch S, Gray S, Heymans S, Haldar SM, Wang B, Pfister O, Cui L, Kumar A, Lin Z, Sen-Banerjee S, Das H, Petersen CA, Mende U, Burleigh BA, Zhu Y, Pinto YM, Pinto Y, Liao R, Jain MK. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7074-9. PMID: 17438289; PMCID: PMC1855421.
  98. Duhaney TA, Cui L, Rude MK, Lebrasseur NK, Ngoy S, De Silva DS, Siwik DA, Liao R, Sam F. Peroxisome proliferator-activated receptor alpha-independent actions of fenofibrate exacerbates left ventricular dilation and fibrosis in chronic pressure overload. Hypertension. 2007 May; 49(5):1084-94. PMID: 17353509.
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  99. Leopold JA, Dam A, Maron BA, Scribner AW, Liao R, Handy DE, Stanton RC, Pitt B, Loscalzo J. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat Med. 2007 Feb; 13(2):189-97. PMID: 17273168; PMCID: PMC3648863.
  100. Liao R, Jain M. Isolation, culture, and functional analysis of adult mouse cardiomyocytes. Methods Mol Med. 2007; 139:251-62. PMID: 18287677.
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  101. Laustsen PG, Russell SJ, Cui L, Entingh-Pearsall A, Holzenberger M, Liao R, Kahn CR. Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function. Mol Cell Biol. 2007 Mar; 27(5):1649-64. PMID: 17189427; PMCID: PMC1820447.
  102. Ichinose F, Buys ES, Neilan TG, Furutani EM, Morgan JG, Jassal DS, Graveline AR, Searles RJ, Lim CC, Kaneki M, Picard MH, Scherrer-Crosbie M, Janssens S, Liao R, Bloch KD. Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock. Circ Res. 2007 Jan 05; 100(1):130-9. PMID: 17138944.
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  103. Prunier F, Pfister O, Hadri L, Liang L, Del Monte F, Liao R, Hajjar RJ. Delayed erythropoietin therapy reduces post-MI cardiac remodeling only at a dose that mobilizes endothelial progenitor cells. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H522-9. PMID: 16997893.
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  104. Yang M, Lim CC, Liao R, Zhang X. A novel microfluidic impedance assay for monitoring endothelin-induced cardiomyocyte hypertrophy. Biosens Bioelectron. 2007 Mar 15; 22(8):1688-93. PMID: 16962309.
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  105. Xiang Z, Liao R, Kelly MS, Spector M. Collagen-GAG scaffolds grafted onto myocardial infarcts in a rat model: a delivery vehicle for mesenchymal stem cells. Tissue Eng. 2006 Sep; 12(9):2467-78. PMID: 16995780.
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  106. Jeong D, Cha H, Kim E, Kang M, Yang DK, Kim JM, Yoon PO, Oh JG, Bernecker OY, Sakata S, Le TT, Cui L, Lee YH, Kim DH, Woo SH, Liao R, Hajjar RJ, Park WJ. PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility. Circ Res. 2006 Aug 04; 99(3):307-14. PMID: 16809552.
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  107. Chen X, Shevtsov SP, Hsich E, Cui L, Haq S, Aronovitz M, Kerkelä R, Molkentin JD, Liao R, Salomon RN, Patten R, Force T. The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy. Mol Cell Biol. 2006 Jun; 26(12):4462-73. PMID: 16738313; PMCID: PMC1489123.
  108. Xiang F, Sakata Y, Cui L, Youngblood JM, Nakagami H, Liao JK, Liao R, Chin MT. Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4. Am J Physiol Heart Circ Physiol. 2006 May; 290(5):H1997-2006. PMID: 16603706; PMCID: PMC2692281.
  109. He Z, Opland DM, Way KJ, Ueki K, Bodyak N, Kang PM, Izumo S, Kulkarni RN, Wang B, Liao R, Kahn CR, King GL. Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):787-93. PMID: 16469952.
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  110. Zhang W, Anger T, Su J, Hao J, Xu X, Zhu M, Gach A, Cui L, Liao R, Mende U. Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy. J Biol Chem. 2006 Mar 03; 281(9):5811-20. PMID: 16380388.
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  111. Mouquet F, Pfister O, Jain M, Oikonomopoulos A, Ngoy S, Summer R, Fine A, Liao R. Restoration of cardiac progenitor cells after myocardial infarction by self-proliferation and selective homing of bone marrow-derived stem cells. Circ Res. 2005 Nov 25; 97(11):1090-2. PMID: 16269652.
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  112. Shiojima I, Sato K, Izumiya Y, Schiekofer S, Ito M, Liao R, Colucci WS, Walsh K. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest. 2005 Aug; 115(8):2108-18. PMID: 16075055; PMCID: PMC1180541.
  113. Pfister O, Jain M, Liao R. Cell therapy in heart failure. Heart Fail Clin. 2005 Jul; 1(2):303-12. PMID: 17386854.
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  114. Pfister O, Mouquet F, Jain M, Summer R, Helmes M, Fine A, Colucci WS, Liao R. CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation. Circ Res. 2005 Jul 08; 97(1):52-61. PMID: 15947249.
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  115. Liao R. Yin and Yang of myocardial transforming growth factor-beta1: timing is everything. Circulation. 2005 May 17; 111(19):2416-7. PMID: 15897356.
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  116. Loscalzo J, Voetsch B, Liao R, Leopold J. Genetic determinants of vascular oxidant stress and endothelial dysfunction. Congest Heart Fail. 2005 Mar-Apr; 11(2):73-9. PMID: 15860972.
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  117. Jain M, Pfister O, Hajjar RJ, Liao R. Mesenchymal stem cells in the infarcted heart. Coron Artery Dis. 2005 Mar; 16(2):93-7. PMID: 15735401.
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  118. Kuster GM, Pimentel DR, Adachi T, Ido Y, Brenner DA, Cohen RA, Liao R, Siwik DA, Colucci WS. Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras. Circulation. 2005 Mar 08; 111(9):1192-8. PMID: 15723974.
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  119. Kuster GM, Kotlyar E, Rude MK, Siwik DA, Liao R, Colucci WS, Sam F. Mineralocorticoid receptor inhibition ameliorates the transition to myocardial failure and decreases oxidative stress and inflammation in mice with chronic pressure overload. Circulation. 2005 Feb 01; 111(4):420-7. PMID: 15687129.
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  120. Taniyama Y, Ito M, Sato K, Kuester C, Veit K, Tremp G, Liao R, Colucci WS, Ivashchenko Y, Walsh K, Shiojima I. Akt3 overexpression in the heart results in progression from adaptive to maladaptive hypertrophy. J Mol Cell Cardiol. 2005 Feb; 38(2):375-85. PMID: 15698844.
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  121. Kuramochi Y, Cote GM, Guo X, Lebrasseur NK, Cui L, Liao R, Sawyer DB. Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling. J Biol Chem. 2004 Dec 03; 279(49):51141-7. PMID: 15385548.
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  122. Huq F, Lebeche D, Iyer V, Liao R, Hajjar RJ. Gene transfer of parvalbumin improves diastolic dysfunction in senescent myocytes. Circulation. 2004 Jun 08; 109(22):2780-5. PMID: 15173024.
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  123. Brenner DA, Jain M, Pimentel DR, Wang B, Connors LH, Skinner M, Apstein CS, Liao R. Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress. Circ Res. 2004 Apr 30; 94(8):1008-10. PMID: 15044325.
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  124. Michael A, Haq S, Chen X, Hsich E, Cui L, Walters B, Shao Z, Bhattacharya K, Kilter H, Huggins G, Andreucci M, Periasamy M, Solomon RN, Liao R, Patten R, Molkentin JD, Force T. Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart. J Biol Chem. 2004 May 14; 279(20):21383-93. PMID: 15020584.
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  125. Maytin M, Siwik DA, Ito M, Xiao L, Sawyer DB, Liao R, Colucci WS. Pressure overload-induced myocardial hypertrophy in mice does not require gp91phox. Circulation. 2004 Mar 09; 109(9):1168-71. PMID: 14981002.
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  126. Jain M, Cui L, Brenner DA, Wang B, Handy DE, Leopold JA, Loscalzo J, Apstein CS, Liao R. Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase. Circulation. 2004 Feb 24; 109(7):898-903. PMID: 14757696.
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  127. Lim CC, Zuppinger C, Guo X, Kuster GM, Helmes M, Eppenberger HM, Suter TM, Liao R, Sawyer DB. Anthracyclines induce calpain-dependent titin proteolysis and necrosis in cardiomyocytes. J Biol Chem. 2004 Feb 27; 279(9):8290-9. PMID: 14676206.
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  128. Deng Q, Liao R, Wu BL, Sun P. High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts. J Biol Chem. 2004 Jan 09; 279(2):1050-9. PMID: 14593117.
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  129. Kuramochi Y, Lim CC, Guo X, Colucci WS, Liao R, Sawyer DB. Myocyte contractile activity modulates norepinephrine cytotoxicity and survival effects of neuregulin-1beta. Am J Physiol Cell Physiol. 2004 Feb; 286(2):C222-9. PMID: 14522821.
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  130. Haq S, Kilter H, Michael A, Tao J, O'Leary E, Sun XM, Walters B, Bhattacharya K, Chen X, Cui L, Andreucci M, Rosenzweig A, Guerrero JL, Patten R, Liao R, Molkentin J, Picard M, Bonventre JV, Force T. Deletion of cytosolic phospholipase A2 promotes striated muscle growth. Nat Med. 2003 Jul; 9(7):944-51. PMID: 12808451.
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  131. Jain M, Brenner DA, Cui L, Lim CC, Wang B, Pimentel DR, Koh S, Sawyer DB, Leopold JA, Handy DE, Loscalzo J, Apstein CS, Liao R. Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circ Res. 2003 Jul 25; 93(2):e9-16. PMID: 12829617.
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  132. Okafor C, Liao R, Perreault-Micale C, Li X, Ito T, Stepanek A, Doye A, de Tombe P, Gwathmey JK. Mg-ATPase and Ca+ activated myosin AtPase activity in ventricular myofibrils from non-failing and diseased human hearts--effects of calcium sensitizing agents MCI-154, DPI 201-106, and caffeine. Mol Cell Biochem. 2003 Mar; 245(1-2):77-89. PMID: 12708747.
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  133. Helmes M, Lim CC, Liao R, Bharti A, Cui L, Sawyer DB. Titin determines the Frank-Starling relation in early diastole. J Gen Physiol. 2003 Feb; 121(2):97-110. PMID: 12566538; PMCID: PMC2217323.
  134. Liao R, Jain M, Cui L, D'Agostino J, Aiello F, Luptak I, Ngoy S, Mortensen RM, Tian R. Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice. Circulation. 2002 Oct 15; 106(16):2125-31. PMID: 12379584.
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  135. Forgione MA, Cap A, Liao R, Moldovan NI, Eberhardt RT, Lim CC, Jones J, Goldschmidt-Clermont PJ, Loscalzo J. Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure. Circulation. 2002 Aug 27; 106(9):1154-8. PMID: 12196344.
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  136. Jain M, Liao R, Podesser BK, Ngoy S, Apstein CS, Eberli FR. Influence of gender on the response to hemodynamic overload after myocardial infarction. Am J Physiol Heart Circ Physiol. 2002 Dec; 283(6):H2544-50. PMID: 12388328.
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  137. Matsui T, Li L, Wu JC, Cook SA, Nagoshi T, Picard MH, Liao R, Rosenzweig A. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem. 2002 Jun 21; 277(25):22896-901. PMID: 11943770.
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  138. Jain M, Lim CC, Nagata K, Davis VM, Milstone DS, Liao R, Mortensen RM. Targeted inactivation of Galpha(i) does not alter cardiac function or beta-adrenergic sensitivity. Am J Physiol Heart Circ Physiol. 2001 Feb; 280(2):H569-75. PMID: 11158953.
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  139. Nagata K, Ye C, Jain M, Milstone DS, Liao R, Mortensen RM. Galpha(i2) but not Galpha(i3) is required for muscarinic inhibition of contractility and calcium currents in adult cardiomyocytes. Circ Res. 2000 Nov 10; 87(10):903-9. PMID: 11073886.
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  140. Cave AC, Ingwall JS, Friedrich J, Liao R, Saupe KW, Apstein CS, Eberli FR. ATP synthesis during low-flow ischemia: influence of increased glycolytic substrate. Circulation. 2000 May 02; 101(17):2090-6. PMID: 10790352.
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  141. Liao R, Nascimben L, Friedrich J, Gwathmey JK, Ingwall JS. Decreased energy reserve in an animal model of dilated cardiomyopathy. Relationship to contractile performance. Circ Res. 1996 May; 78(5):893-902. PMID: 8620610.
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  142. Paige JA, Liao R, Hajjar RJ, Foisy RL, Cory CR, O'Brien PJ, Gwathmey JK. Effect of a high omega-3 fatty acid diet on cardiac contractile performance in Oncorhynchus mykiss. Cardiovasc Res. 1996 Feb; 31(2):249-62. PMID: 8730402.
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  143. Gwathmey JK, Liao R, Helm PA, Thaiyananthan G, Hajjar RJ. Is contractility depressed in the failing human heart? Cardiovasc Drugs Ther. 1995 Aug; 9(4):581-7. PMID: 8547208.
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  144. Gwathmey JK, Liao R, Ingwall JS. Comparison of twitch force and calcium handling in papillary muscles from right ventricular pressure overload hypertrophy in weanling and juvenile ferrets. Cardiovasc Res. 1995 Apr; 29(4):475-81. PMID: 7796440.
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  145. Nascimben L, Friedrich J, Liao R, Pauletto P, Pessina AC, Ingwall JS. Enalapril treatment increases cardiac performance and energy reserve via the creatine kinase reaction in myocardium of Syrian myopathic hamsters with advanced heart failure. Circulation. 1995 Mar 15; 91(6):1824-33. PMID: 7882493.
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  146. Liao R, Helm PA, Hajjar RJ, Saha C, Gwathmey JK. [Ca2+]i in human heart failure: a review and discussion of current areas of controversy. Yale J Biol Med. 1994 Sep-Dec; 67(5-6):247-64. PMID: 8579641; PMCID: PMC2588906.
  147. Liao R, Gwathmey JK. Effects of MCI-154 and caffeine on Ca(++)-regulated interactions between troponin subunits from bovine heart. J Pharmacol Exp Ther. 1994 Aug; 270(2):831-9. PMID: 8071875.
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  148. Glass MG, Fuleihan F, Liao R, Lincoff AM, Chapados R, Hamlin R, Apstein CS, Allen PD, Ingwall JS, Hajjar RJ, et al. Differences in cardioprotective efficacy of adrenergic receptor antagonists and Ca2+ channel antagonists in an animal model of dilated cardiomyopathy. Effects on gross morphology, global cardiac function, and twitch force. Circ Res. 1993 Dec; 73(6):1077-89. PMID: 8222079.
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  149. Hajjar RJ, Liao R, Young JB, Fuleihan F, Glass MG, Gwathmey JK. Pathophysiological and biochemical characterisation of an avian model of dilated cardiomyopathy: comparison to findings in human dilated cardiomyopathy. Cardiovasc Res. 1993 Dec; 27(12):2212-21. PMID: 8313431.
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  150. Friedrich J, Nascimben L, Liao R, Ingwall JS. Phosphocreatine T1 measurements with and without exchange in the heart. Magn Reson Med. 1993 Jul; 30(1):45-50. PMID: 8371674.
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