Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Lee Gehrke, Ph.D.

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Other Positions
Title
Institution
Department

Mentoring
completed student projects
The Substitution Rate and Evolutionary Dynamics of P. falciparum in Culture
Part Time, 06/04/12 - 02/04/13

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. U19AI131135 (GEHRKE, LEE) Apr 1, 2017 - Mar 31, 2022
    NIH
    3D Models of Engineered Human iPS Cells to Investigate Neurotropic Virus Infections
    Role: Principal Investigator
  2. R33AI100190 (GEHRKE, LEE) Jun 1, 2012 - Aug 31, 2018
    NIH
    MMDx: A rapid multiplexed matrix code diagnostic for real time epidemiology
    Role: Principal Investigator
  3. R21AI100190 (GEHRKE, LEE) Jun 1, 2012 - Aug 31, 2014
    NIH
    MMDx: A rapid multiplexed matrix code diagnostic for real time epidemiology
    Role: Principal Investigator
  4. R21CA159132 (GEHRKE, LEE) Mar 12, 2012 - Feb 28, 2015
    NIH
    Synergistic innate immune activation and cell killing by RIG-I ligands in HCV-HCC
    Role: Principal Investigator
  5. R01GM042504 (GEHRKE, LEE) Jul 1, 1989 - Mar 31, 2005
    NIH
    CONTROL OF CELL FUNCTION VIA SELECTIVE MRNA TRANSLATION
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. de Puig H, Bosch I, Salcedo N, Collins JJ, Hamad-Schifferli K, Gehrke L. Multiplexed rapid antigen tests developed using multicolored nanoparticles and cross-reactive antibody pairs: Implications for pandemic preparedness. Nano Today. 2022 Dec; 47:101669. PMID: 36348742; PMCID: PMC9632299.
    Citations:    
  2. Losada PX, Bosch I, Frydman GH, Gehrke L, Narváez CF. Dengue and Zika virus differential infection of human megakaryoblast MEG-01 reveals unique cellular markers. Virology. 2022 Oct 13; 577:16-23. PMID: 36257128.
    Citations:    Fields:    
  3. Richards A, Friesen M, Khalil A, Barrasa MI, Gehrke L, Jaenisch R. SARS-CoV-2 infection of human pluripotent stem cell-derived liver organoids reveals potential mechanisms of liver pathology. iScience. 2022 Oct 21; 25(10):105146. PMID: 36128218; PMCID: PMC9477603.
    Citations: 1     
  4. Junqueira C, Crespo Â, Ranjbar S, de Lacerda LB, Lewandrowski M, Ingber J, Parry B, Ravid S, Clark S, Schrimpf MR, Ho F, Beakes C, Margolin J, Russell N, Kays K, Boucau J, Das Adhikari U, Vora SM, Leger V, Gehrke L, Henderson LA, Janssen E, Kwon D, Sander C, Abraham J, Goldberg MB, Wu H, Mehta G, Bell S, Goldfeld AE, Filbin MR, Lieberman J. Fc?R-mediated SARS-CoV-2 infection of monocytes activates inflammation. Nature. 2022 06; 606(7914):576-584. PMID: 35385861.
    Citations: 108     Fields:    Translation:HumansCells
  5. Vora SM, Fontana P, Mao T, Leger V, Zhang Y, Fu TM, Lieberman J, Gehrke L, Shi M, Wang L, Iwasaki A, Wu H. Targeting stem-loop 1 of the SARS-CoV-2 5' UTR to suppress viral translation and Nsp1 evasion. Proc Natl Acad Sci U S A. 2022 03 01; 119(9). PMID: 35149555; PMCID: PMC8892331.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  6. Jeong M, Ocwieja KE, Han D, Wackym PA, Zhang Y, Brown A, Moncada C, Vambutas A, Kanne T, Crain R, Siegel N, Leger V, Santos F, Welling DB, Gehrke L, Stankovic KM. Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction. Commun Med (Lond). 2021; 1(1):44. PMID: 34870285; PMCID: PMC8633908.
    Citations: 25     
  7. Junqueira C, Crespo Â, Ranjbar S, Lewandrowski M, Ingber J, de Lacerda LB, Parry B, Ravid S, Clark S, Ho F, Vora SM, Leger V, Beakes C, Margolin J, Russell N, Kays K, Gehrke L, Adhikari UD, Henderson L, Janssen E, Kwon D, Sander C, Abraham J, Filbin M, Goldberg MB, Wu H, Mehta G, Bell S, Goldfeld AE, Lieberman J. SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release. Res Sq. 2021 Aug 11. PMID: 34401873; PMCID: PMC8366805.
    Citations:    
  8. Junqueira C, Crespo Â, Ranjbar S, Ingber J, Parry B, Ravid S, de Lacerda LB, Lewandrowski M, Clark S, Ho F, Vora SM, Leger V, Beakes C, Margolin J, Russell N, Gehrke L, Adhikari UD, Henderson L, Janssen E, Kwon D, Sander C, Abraham J, Filbin M, Goldberg MB, Wu H, Mehta G, Bell S, Goldfeld AE, Lieberman J. SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release. medRxiv. 2021 Mar 08. PMID: 33758872; PMCID: PMC7987031.
    Citations: 2     
  9. Albanese A, Swaney JM, Yun DH, Evans NB, Antonucci JM, Velasco S, Sohn CH, Arlotta P, Gehrke L, Chung K. Multiscale 3D phenotyping of human cerebral organoids. Sci Rep. 2020 12 08; 10(1):21487. PMID: 33293587; PMCID: PMC7723053.
    Citations: 18     Fields:    Translation:HumansCells
  10. Giovannoni F, Bosch I, Polonio CM, Torti MF, Wheeler MA, Li Z, Romorini L, Rodriguez Varela MS, Rothhammer V, Barroso A, Tjon EC, Sanmarco LM, Takenaka MC, Modaresi SMS, Gutiérrez-Vázquez C, Zanluqui NG, Dos Santos NB, Munhoz CD, Wang Z, Damonte EB, Sherr D, Gehrke L, Peron JPS, Garcia CC, Quintana FJ. Author Correction: AHR is a Zika virus host factor and a candidate target for antiviral therapy. Nat Neurosci. 2020 Oct; 23(10):1307. PMID: 32778795.
    Citations:    Fields:    
  11. Reddy A, Bosch I, Salcedo N, Herrera BB, de Puig H, Narváez CF, Caicedo-Borrero DM, Lorenzana I, Parham L, García K, Mercado M, Turca AMR, Villar-Centeno LA, Gélvez-Ramírez M, Ríos NAG, Hiley M, García D, Diamond MS, Gehrke L. Development and Validation of a Rapid Lateral Flow E1/E2-Antigen Test and ELISA in Patients Infected with Emerging Asian Strain of Chikungunya Virus in the Americas. Viruses. 2020 09 01; 12(9). PMID: 32882998.
    Citations: 8     Fields:    Translation:HumansCells
  12. Giovannoni F, Bosch I, Polonio CM, Torti MF, Wheeler MA, Li Z, Romorini L, Rodriguez Varela MS, Rothhammer V, Barroso A, Tjon EC, Sanmarco LM, Takenaka MC, Modaresi SMS, Gutiérrez-Vázquez C, Zanluqui NG, Dos Santos NB, Munhoz CD, Wang Z, Damonte EB, Sherr D, Gehrke L, Peron JPS, Garcia CC, Quintana FJ. AHR is a Zika virus host factor and a candidate target for antiviral therapy. Nat Neurosci. 2020 08; 23(8):939-951. PMID: 32690969; PMCID: PMC7897397.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  13. Bosch I, Reddy A, de Puig H, Ludert JE, Perdomo-Celis F, Narváez CF, Versiani A, Fandos D, Nogueira ML, Singla M, Lodha R, Medigeshi GR, Lorenzana I, Ralde HV, Gélvez-Ramírez M, Villar LA, Hiley M, Mendoza L, Salcedo N, Herrera BB, Gehrke L. Serotype-specific detection of dengue viruses in a nonstructural protein 1-based enzyme-linked immunosorbent assay validated with a multi-national cohort. PLoS Negl Trop Dis. 2020 06; 14(6):e0008203. PMID: 32579555.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  14. de Puig H, Bosch I, Collins JJ, Gehrke L. Point-of-Care Devices to Detect Zika and Other Emerging Viruses. Annu Rev Biomed Eng. 2020 06 04; 22:371-386. PMID: 32501770.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  15. Basak A, Munschauer M, Lareau CA, Montbleau KE, Ulirsch JC, Hartigan CR, Schenone M, Lian J, Wang Y, Huang Y, Wu X, Gehrke L, Rice CM, An X, Christou HA, Mohandas N, Carr SA, Chen JJ, Orkin SH, Lander ES, Sankaran VG. Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation. Nat Genet. 2020 02; 52(2):138-145. PMID: 31959994; PMCID: PMC7031047.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  16. Antonucci J, Gehrke L. Cerebral Organoid Models for Neurotropic Viruses. ACS Infect Dis. 2019 12 13; 5(12):1976-1979. PMID: 31580050.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  17. Li Y, Muffat J, Omer Javed A, Keys HR, Lungjangwa T, Bosch I, Khan M, Virgilio MC, Gehrke L, Sabatini DM, Jaenisch R. Genome-wide CRISPR screen for Zika virus resistance in human neural cells. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9527-9532. PMID: 31019072.
    Citations: 46     Fields:    Translation:HumansCells
  18. Metsky HC, Siddle KJ, Gladden-Young A, Qu J, Yang DK, Brehio P, Goldfarb A, Piantadosi A, Wohl S, Carter A, Lin AE, Barnes KG, Tully DC, Corleis B, Hennigan S, Barbosa-Lima G, Vieira YR, Paul LM, Tan AL, Garcia KF, Parham LA, Odia I, Eromon P, Folarin OA, Goba A, Simon-Lorière E, Hensley L, Balmaseda A, Harris E, Kwon DS, Allen TM, Runstadler JA, Smole S, Bozza FA, Souza TML, Isern S, Michael SF, Lorenzana I, Gehrke L, Bosch I, Ebel G, Grant DS, Happi CT, Park DJ, Gnirke A, Sabeti PC, Matranga CB. Capturing sequence diversity in metagenomes with comprehensive and scalable probe design. Nat Biotechnol. 2019 02; 37(2):160-168. PMID: 30718881; PMCID: PMC6587591.
    Citations: 51     Fields:    Translation:HumansAnimalsPHPublic Health
  19. Muffat J, Li Y, Omer A, Durbin A, Bosch I, Bakiasi G, Richards E, Meyer A, Gehrke L, Jaenisch R. Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections. Proc Natl Acad Sci U S A. 2018 07 03; 115(27):7117-7122. PMID: 29915057; PMCID: PMC6142255.
    Citations: 58     Fields:    Translation:HumansCells
  20. Myhrvold C, Freije CA, Gootenberg JS, Abudayyeh OO, Metsky HC, Durbin AF, Kellner MJ, Tan AL, Paul LM, Parham LA, Garcia KF, Barnes KG, Chak B, Mondini A, Nogueira ML, Isern S, Michael SF, Lorenzana I, Yozwiak NL, MacInnis BL, Bosch I, Gehrke L, Zhang F, Sabeti PC. Field-deployable viral diagnostics using CRISPR-Cas13. Science. 2018 04 27; 360(6387):444-448. PMID: 29700266.
    Citations: 356     Fields:    Translation:HumansCells
  21. Khajuria RK, Munschauer M, Ulirsch JC, Fiorini C, Ludwig LS, McFarland SK, Abdulhay NJ, Specht H, Keshishian H, Mani DR, Jovanovic M, Ellis SR, Fulco CP, Engreitz JM, Schütz S, Lian J, Gripp KW, Weinberg OK, Pinkus GS, Gehrke L, Regev A, Lander ES, Gazda HT, Lee WY, Panse VG, Carr SA, Sankaran VG. Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis. Cell. 2018 03 22; 173(1):90-103.e19. PMID: 29551269.
    Citations: 160     Fields:    Translation:HumansCells
  22. de Puig H, Bosch I, Gehrke L, Hamad-Schifferli K. Challenges of the Nano-Bio Interface in Lateral Flow and Dipstick Immunoassays. Trends Biotechnol. 2017 12; 35(12):1169-1180. PMID: 28965747; PMCID: PMC5696013.
    Citations: 25     Fields:    Translation:Humans
  23. Bosch I, de Puig H, Hiley M, Carré-Camps M, Perdomo-Celis F, Narváez CF, Salgado DM, Senthoor D, O'Grady M, Phillips E, Durbin A, Fandos D, Miyazaki H, Yen CW, Gélvez-Ramírez M, Warke RV, Ribeiro LS, Teixeira MM, Almeida RP, Muñóz-Medina JE, Ludert JE, Nogueira ML, Colombo TE, Terzian ACB, Bozza PT, Calheiros AS, Vieira YR, Barbosa-Lima G, Vizzoni A, Cerbino-Neto J, Bozza FA, Souza TML, Trugilho MRO, de Filippis AMB, de Sequeira PC, Marques ETA, Magalhaes T, Díaz FJ, Restrepo BN, Marín K, Mattar S, Olson D, Asturias EJ, Lucera M, Singla M, Medigeshi GR, de Bosch N, Tam J, Gómez-Márquez J, Clavet C, Villar L, Hamad-Schifferli K, Gehrke L. Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum. Sci Transl Med. 2017 Sep 27; 9(409). PMID: 28954927; PMCID: PMC6612058.
    Citations: 74     Fields:    Translation:HumansCells
  24. Sánchez-Purrà M, Roig-Solvas B, Versiani A, Rodríguez-Quijada C, de Puig H, Bosch I, Gehrke L, Hamad-Schifferli K. Design of SERS nanotags for multiplexed lateral flow immunoassays. Mol Syst Des Eng. 2017 Oct 01; 2(4):401-409. PMID: 31681479; PMCID: PMC6823989.
    Citations: 6     
  25. Sánchez-Purrà M, Carré-Camps M, de Puig H, Bosch I, Gehrke L, Hamad-Schifferli K. Surface-Enhanced Raman Spectroscopy-Based Sandwich Immunoassays for Multiplexed Detection of Zika and Dengue Viral Biomarkers. ACS Infect Dis. 2017 10 13; 3(10):767-776. PMID: 28875696.
    Citations: 44     Fields:    Translation:AnimalsCells
  26. Metsky HC, Matranga CB, Wohl S, Schaffner SF, Freije CA, Winnicki SM, West K, Qu J, Baniecki ML, Gladden-Young A, Lin AE, Tomkins-Tinch CH, Ye SH, Park DJ, Luo CY, Barnes KG, Shah RR, Chak B, Barbosa-Lima G, Delatorre E, Vieira YR, Paul LM, Tan AL, Barcellona CM, Porcelli MC, Vasquez C, Cannons AC, Cone MR, Hogan KN, Kopp EW, Anzinger JJ, Garcia KF, Parham LA, Ramírez RMG, Montoya MCM, Rojas DP, Brown CM, Hennigan S, Sabina B, Scotland S, Gangavarapu K, Grubaugh ND, Oliveira G, Robles-Sikisaka R, Rambaut A, Gehrke L, Smole S, Halloran ME, Villar L, Mattar S, Lorenzana I, Cerbino-Neto J, Valim C, Degrave W, Bozza PT, Gnirke A, Andersen KG, Isern S, Michael SF, Bozza FA, Souza TML, Bosch I, Yozwiak NL, MacInnis BL, Sabeti PC. Zika virus evolution and spread in the Americas. Nature. 2017 06 15; 546(7658):411-415. PMID: 28538734.
    Citations: 169     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  27. Li Y, Muffat J, Omer A, Bosch I, Lancaster MA, Sur M, Gehrke L, Knoblich JA, Jaenisch R. Induction of Expansion and Folding in Human Cerebral Organoids. Cell Stem Cell. 2017 03 02; 20(3):385-396.e3. PMID: 28041895; PMCID: PMC6461394.
    Citations: 171     Fields:    Translation:HumansAnimalsCells
  28. Tam JO, de Puig H, Yen CW, Bosch I, Gómez-Márquez J, Clavet C, Hamad-Schifferli K, Gehrke L. A comparison of nanoparticle-antibody conjugation strategies in sandwich immunoassays. J Immunoassay Immunochem. 2017; 38(4):355-377. PMID: 27982728.
    Citations: 9     Fields:    Translation:Humans
  29. Durbin AF, Wang C, Marcotrigiano J, Gehrke L. RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling. mBio. 2016 09 20; 7(5). PMID: 27651356.
    Citations: 102     Fields:    Translation:HumansCells
  30. Pardee K, Green AA, Takahashi MK, Braff D, Lambert G, Lee JW, Ferrante T, Ma D, Donghia N, Fan M, Daringer NM, Bosch I, Dudley DM, O'Connor DH, Gehrke L, Collins JJ. Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components. Cell. 2016 May 19; 165(5):1255-1266. PMID: 27160350.
    Citations: 349     Fields:    Translation:AnimalsCells
  31. de Puig H, Tam JO, Yen CW, Gehrke L, Hamad-Schifferli K. Extinction Coefficient of Gold Nanostars. J Phys Chem C Nanomater Interfaces. 2015 Jul 30; 119(30):17408-17415. PMID: 28018519; PMCID: PMC5176261.
    Citations: 34     
  32. Yen CW, de Puig H, Tam JO, Gómez-Márquez J, Bosch I, Hamad-Schifferli K, Gehrke L. Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses. Lab Chip. 2015 Apr 07; 15(7):1638-41. PMID: 25672590.
    Citations: 81     Fields:    Translation:HumansCells
  33. Odendall C, Dixit E, Stavru F, Bierne H, Franz KM, Durbin AF, Boulant S, Gehrke L, Cossart P, Kagan JC. Diverse intracellular pathogens activate type III interferon expression from peroxisomes. Nat Immunol. 2014 Aug; 15(8):717-26. PMID: 24952503; PMCID: PMC4106986.
    Citations: 207     Fields:    Translation:HumansAnimalsCells
  34. Gomila RC, Martin GW, Gehrke L. NF90 binds the dengue virus RNA 3' terminus and is a positive regulator of dengue virus replication. PLoS One. 2011 Feb 28; 6(2):e16687. PMID: 21386893.
    Citations: 53     Fields:    Translation:HumansCells
  35. Simon AE, Gehrke L. RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAs. Biochim Biophys Acta. 2009 Sep-Oct; 1789(9-10):571-83. PMID: 19501200.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  36. Uzri D, Gehrke L. Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities. J Virol. 2009 May; 83(9):4174-84. PMID: 19224987.
    Citations: 97     Fields:    Translation:HumansCells
  37. Gomila RC, Gehrke L. Biochemical approaches for characterizing RNA-protein complexes in preparation for high resolution structure analysis. Methods Mol Biol. 2008; 451:279-91. PMID: 18370263.
    Citations: 2     Fields:    Translation:HumansCells
  38. Reichert VL, Choi M, Petrillo JE, Gehrke L. Alfalfa mosaic virus coat protein bridges RNA and RNA-dependent RNA polymerase in vitro. Virology. 2007 Jul 20; 364(1):214-26. PMID: 17400272; PMCID: PMC2583179.
    Citations: 13     Fields:    Translation:Cells
  39. Boyce M, Scott F, Guogas LM, Gehrke L. Base-pairing potential identified by in vitro selection predicts the kinked RNA backbone observed in the crystal structure of the alfalfa mosaic virus RNA-coat protein complex. J Mol Recognit. 2006 Jan-Feb; 19(1):68-78. PMID: 16312015.
    Citations: 2     Fields:    Translation:Cells
  40. Guogas LM, Laforest SM, Gehrke L. Coat protein activation of alfalfa mosaic virus replication is concentration dependent. J Virol. 2005 May; 79(9):5752-61. PMID: 15827190; PMCID: PMC1082755.
    Citations: 14     Fields:    Translation:Cells
  41. Petrillo JE, Rocheleau G, Kelley-Clarke B, Gehrke L. Evaluation of the conformational switch model for alfalfa mosaic virus RNA replication. J Virol. 2005 May; 79(9):5743-51. PMID: 15827189; PMCID: PMC1082754.
    Citations: 9     Fields:    Translation:Cells
  42. Guogas LM, Filman DJ, Hogle JM, Gehrke L. Cofolding organizes alfalfa mosaic virus RNA and coat protein for replication. Science. 2004 Dec 17; 306(5704):2108-11. PMID: 15604410.
    Citations: 14     Fields:    Translation:Cells
  43. Rocheleau G, Petrillo J, Guogas L, Gehrke L. Degenerate in vitro genetic selection reveals mutations that diminish alfalfa mosaic virus RNA replication without affecting coat protein binding. J Virol. 2004 Aug; 78(15):8036-46. PMID: 15254175; PMCID: PMC446135.
    Citations: 4     Fields:    Translation:Cells
  44. Laforest SM, Gehrke L. Spatial determinants of the alfalfa mosaic virus coat protein binding site. RNA. 2004 Jan; 10(1):48-58. PMID: 14681584.
    Citations: 5     Fields:    Translation:Cells
  45. Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Sossin W, Standart N, Tahara SM, Thomas AA, Toulmé JJ, Wilusz J, Wimmer E, Witherell G, Wormington M. New ways of initiating translation in eukaryotes. Mol Cell Biol. 2001 Dec; 21(23):8238-46. PMID: 11710333.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  46. Ansel-McKinney P, Gehrke L. RNA determinants of a specific RNA-coat protein peptide interaction in alfalfa mosaic virus: conservation of homologous features in ilarvirus RNAs. J Mol Biol. 1998 May 15; 278(4):767-85. PMID: 9614941.
    Citations: 12     Fields:    Translation:Cells
  47. Swanson MM, Ansel-McKinney P, Houser-Scott F, Yusibov V, Loesch-Fries LS, Gehrke L. Viral coat protein peptides with limited sequence homology bind similar domains of alfalfa mosaic virus and tobacco streak virus RNAs. J Virol. 1998 Apr; 72(4):3227-34. PMID: 9525649; PMCID: PMC109790.
    Citations: 4     Fields:    Translation:Cells
  48. MacBeth KJ, Ro YT, Gehrke L, Patterson JL. Cleavage site mapping and substrate-specificity of Leishmaniavirus 2-1 capsid endoribonuclease activity. J Biochem. 1997 Jul; 122(1):193-200. PMID: 9276688.
    Citations: 4     Fields:    Translation:Cells
  49. Hann LE, Webb AC, Cai JM, Gehrke L. Identification of a competitive translation determinant in the 3' untranslated region of alfalfa mosaic virus coat protein mRNA. Mol Cell Biol. 1997 Apr; 17(4):2005-13. PMID: 9121448.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  50. Houser-Scott F, Ansel-McKinney P, Cai JM, Gehrke L. In vitro genetic selection analysis of alfalfa mosaic virus coat protein binding to 3'-terminal AUGC repeats in the viral RNAs. J Virol. 1997 Mar; 71(3):2310-9. PMID: 9032367; PMCID: PMC191340.
    Citations: 11     Fields:    Translation:Cells
  51. Ansel-McKinney P, Scott SW, Swanson M, Ge X, Gehrke L. A plant viral coat protein RNA binding consensus sequence contains a crucial arginine. EMBO J. 1996 Sep 16; 15(18):5077-84. PMID: 8890181; PMCID: PMC452247.
    Citations: 21     Fields:    Translation:Cells
  52. Rousseau D, Kaspar R, Rosenwald I, Gehrke L, Sonenberg N. Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc Natl Acad Sci U S A. 1996 Feb 06; 93(3):1065-70. PMID: 8577715; PMCID: PMC40031.
    Citations: 149     Fields:    Translation:HumansAnimalsCells
  53. Rosenwald IB, Kaspar R, Rousseau D, Gehrke L, Leboulch P, Chen JJ, Schmidt EV, Sonenberg N, London IM. Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels. J Biol Chem. 1995 Sep 08; 270(36):21176-80. PMID: 7673150.
    Citations: 73     Fields:    Translation:AnimalsCells
  54. Gray ML, Burstein D, Lesperance LM, Gehrke L. Magnetization transfer in cartilage and its constituent macromolecules. Magn Reson Med. 1995 Sep; 34(3):319-25. PMID: 7500869.
    Citations: 37     Fields:    Translation:Animals
  55. Hann LE, Gehrke L. mRNAs containing the unstructured 5' leader sequence of alfalfa mosaic virus RNA 4 translate inefficiently in lysates from poliovirus-infected HeLa cells. J Virol. 1995 Aug; 69(8):4986-93. PMID: 7609069; PMCID: PMC189315.
    Citations: 5     Fields:    Translation:HumansCells
  56. Chefalo PJ, Yang JM, Ramaiah KV, Gehrke L, Chen JJ. Inhibition of protein synthesis in insect cells by baculovirus-expressed heme-regulated eIF-2 alpha kinase. J Biol Chem. 1994 Oct 14; 269(41):25788-94. PMID: 7929284.
    Citations: 9     Fields:    Translation:AnimalsCells
  57. Kaspar RL, Gehrke L. Peripheral blood mononuclear cells stimulated with C5a or lipopolysaccharide to synthesize equivalent levels of IL-1 beta mRNA show unequal IL-1 beta protein accumulation but similar polyribosome profiles. J Immunol. 1994 Jul 01; 153(1):277-86. PMID: 8207242.
    Citations: 19     Fields:    Translation:HumansCells
  58. Houser-Scott F, Baer ML, Liem KF, Cai JM, Gehrke L. Nucleotide sequence and structural determinants of specific binding of coat protein or coat protein peptides to the 3' untranslated region of alfalfa mosaic virus RNA 4. J Virol. 1994 Apr; 68(4):2194-205. PMID: 8139004; PMCID: PMC236695.
    Citations: 25     Fields:    Translation:Cells
  59. Gehrke LE, Scott SD. Development of a pregnancy policy for air medical personnel: an administrative approach. Air Med J. 1994 Feb; 13(2):60-2. PMID: 10131605.
    Citations:    Fields:    Translation:Humans
  60. Baer ML, Houser F, Loesch-Fries LS, Gehrke L. Specific RNA binding by amino-terminal peptides of alfalfa mosaic virus coat protein. EMBO J. 1994 Feb 01; 13(3):727-35. PMID: 8313916; PMCID: PMC394864.
    Citations: 35     Fields:    Translation:AnimalsCells
  61. Auron PE, Quigley GJ, Rosenwasser LJ, Gehrke L. Multiple amino acid substitutions suggest a structural basis for the separation of biological activity and receptor binding in a mutant interleukin-1 beta protein. Biochemistry. 1992 Jul 28; 31(29):6632-8. PMID: 1386253.
    Citations: 2     Fields:    Translation:HumansCells
  62. Webb AC, Bradley MK, Phelan SA, Wu JQ, Gehrke L. Use of the polymerase chain reaction for screening and evaluation of recombinant baculovirus clones. Biotechniques. 1991 Oct; 11(4):512-9. PMID: 1793586.
    Citations: 1     Fields:    Translation:AnimalsCells
  63. Chen JJ, Throop MS, Gehrke L, Kuo I, Pal JK, Brodsky M, London IM. Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase. Proc Natl Acad Sci U S A. 1991 Sep 01; 88(17):7729-33. PMID: 1679235; PMCID: PMC52376.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  64. Tumer NE, Kaniewski W, Haley L, Gehrke L, Lodge JK, Sanders P. The second amino acid of alfalfa mosaic virus coat protein is critical for coat protein-mediated protection. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2331-5. PMID: 11607167; PMCID: PMC51225.
    Citations: 5     Fields:    
  65. Chen JJ, Pal JK, Petryshyn R, Kuo I, Yang JM, Throop MS, Gehrke L, London IM. Amino acid microsequencing of internal tryptic peptides of heme-regulated eukaryotic initiation factor 2 alpha subunit kinase: homology to protein kinases. Proc Natl Acad Sci U S A. 1991 Jan 15; 88(2):315-9. PMID: 1671169; PMCID: PMC50801.
    Citations: 14     Fields:    Translation:AnimalsCells
  66. Gehrke L, Jobling SA, Paik LS, McDonald B, Rosenwasser LJ, Auron PE. A point mutation uncouples human interleukin-1 beta biological activity and receptor binding. J Biol Chem. 1990 Apr 15; 265(11):5922-5. PMID: 2138611.
    Citations: 17     Fields:    Translation:HumansCells
  67. Jobling SA, Auron PE, Gurka G, Webb AC, McDonald B, Rosenwasser LJ, Gehrke L. Biological activity and receptor binding of human prointerleukin-1 beta and subpeptides. J Biol Chem. 1988 Nov 05; 263(31):16372-8. PMID: 2972707.
    Citations: 14     Fields:    Translation:HumansCells
  68. Browning KS, Lax SR, Humphreys J, Ravel JM, Jobling SA, Gehrke L. Evidence that the 5'-untranslated leader of mRNA affects the requirement for wheat germ initiation factors 4A, 4F, and 4G. J Biol Chem. 1988 Jul 15; 263(20):9630-4. PMID: 3260235.
    Citations: 19     Fields:    Translation:AnimalsCells
  69. Jobling SA, Cuthbert CM, Rogers SG, Fraley RT, Gehrke L. In vitro transcription and translational efficiency of chimeric SP6 messenger RNAs devoid of 5' vector nucleotides. Nucleic Acids Res. 1988 May 25; 16(10):4483-98. PMID: 3260027; PMCID: PMC336643.
    Citations: 15     Fields:    Translation:AnimalsCells
  70. Jobling SA, Gehrke L. Enhanced translation of chimaeric messenger RNAs containing a plant viral untranslated leader sequence. Nature. 1987 Feb 12-18; 325(6105):622-5. PMID: 3492677.
    Citations: 91     Fields:    Translation:AnimalsCells
  71. Rosenwasser LJ, Webb AC, Clark BD, Irie S, Chang L, Dinarello CA, Gehrke L, Wolff SM, Rich A, Auron PE. Expression of biologically active human interleukin 1 subpeptides by transfected simian COS cells. Proc Natl Acad Sci U S A. 1986 Jul; 83(14):5243-6. PMID: 3487789; PMCID: PMC323927.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  72. Quigley GJ, Gehrke L, Roth DA, Auron PE. Computer-aided nucleic acid secondary structure modeling incorporating enzymatic digestion data. Nucleic Acids Res. 1984 Jan 11; 12(1 Pt 1):347-66. PMID: 6320093; PMCID: PMC321009.
    Citations: 18     Fields:    Translation:Cells
  73. Gehrke L, Auron PE, Quigley GJ, Rich A, Sonenberg N. 5'-Conformation of capped alfalfa mosaic virus ribonucleic acid 4 may reflect its independence of the cap structure or of cap-binding protein for efficient translation. Biochemistry. 1983 Oct 25; 22(22):5157-64. PMID: 6317016.
    Citations: 30     Fields:    Translation:AnimalsCells
  74. Gehrke L, Ilan J. Preferential utilization of exogenously supplied leucine for protein synthesis in estradiol-induced and uninduced cockerel liver explants. Proc Natl Acad Sci U S A. 1983 Jun; 80(11):3274-8. PMID: 6574484; PMCID: PMC394023.
    Citations: 3     Fields:    Translation:AnimalsCells
  75. Gehrke L, Bast RE, Ilan J. An analysis of rates of polypeptide chain elongation in avian liver explants following in vivo estrogen treatment. I. Determination of average rates of polypeptide chain elongation. J Biol Chem. 1981 Mar 10; 256(5):2514-21. PMID: 7462253.
    Citations: 7     Fields:    Translation:AnimalsCells
  76. Gehrke L, Bast RE, Ilan J. An analysis of rates of polypeptide chain elongation in avian liver explants following in vivo estrogen treatment. II. Determination of the specific rates of elongation of serum albumin and vitellogenin nascent chains. J Biol Chem. 1981 Mar 10; 256(5):2522-30. PMID: 6780565.
    Citations: 5     Fields:    Translation:AnimalsCells
  77. Bast RE, Garfield SA, Gehrke L, Ilan J. Coordination of ribosome content and polysome formation during estradiol stimulation of vitellogenin synthesis in immature male chick livers. Proc Natl Acad Sci U S A. 1977 Aug; 74(8):3133-7. PMID: 269377; PMCID: PMC431465.
    Citations: 5     Fields:    Translation:AnimalsCells
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