Harvard Catalyst Profiles

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Bruce Furie, M.D.

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Mentoring
The role of CD74 in blocking apoptosis during cancer
Summer, 06/15/09 - 08/07/09

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL136394 (FURIE, BRUCE) Apr 1, 2017 - Mar 31, 2021
    NIH/NHLBI
    Vascular Thiol Isomerases in Thrombosis
    Role: Principal Investigator
  2. R13HL134226 (FURIE, BRUCE) Aug 1, 2016 - Jul 31, 2017
    NIH/NHLBI
    FASEB SRC on Functional Disulfide Bonds in Health and Disease
    Role: Principal Investigator
  3. U54HL112302 (FURIE, BRUCE) Sep 1, 2012 - Apr 30, 2017
    NIH/NHLBI
    Protein disulfide isomerases: A new class of antithrombotic targets
    Role: Principal Investigator
  4. R01HL095084 (FURIE, BRUCE) Sep 26, 2008 - Jul 31, 2014
    NIH/NHLBI
    Cancer, venous thromboembolic disease and tissue factor-bearing microparticles
    Role: Principal Investigator
  5. P01HL087203 (FURIE, BRUCE) Sep 1, 2008 - May 31, 2014
    NIH/NHLBI
    Thrombus Formation In Vivo
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bury L, Megy K, Stephens JC, Grassi L, Greene D, Gleadall N, Althaus K, Allsup D, Bariana TK, Bonduel M, Butta NV, Collins P, Curry N, Deevi SVV, Downes K, Duarte D, Elliott K, Falcinelli E, Furie B, Keeling D, Lambert MP, Linger R, Mangles S, Mapeta R, Millar CM, Penkett C, Perry DJ, Stirrups KE, Turro E, Westbury SK, Wu J, BioResource N, Gomez K, Freson K, Ouwehand WH, Gresele P, Simeoni I. Next-generation sequencing for the diagnosis of MYH9-RD: Predicting pathogenic variants. Hum Mutat. 2020 Jan; 41(1):277-290. PMID: 31562665.
    Citations:    
  2. Zwicker JI, Schlechter BL, Stopa JD, Liebman HA, Aggarwal A, Puligandla M, Caughey T, Bauer KA, Kuemmerle N, Wong E, Wun T, McLaughlin M, Hidalgo M, Neuberg D, Furie B, Flaumenhaft R. Targeting protein disulfide isomerase with the flavonoid isoquercetin to improve hypercoagulability in advanced cancer. JCI Insight. 2019 02 21; 4(4). PMID: 30652973.
    Citations:    Fields:    
  3. Eriksson O, Chiu J, Hogg PJ, Atkinson JP, Liszewski MK, Flaumenhaft R, Furie B. Thiol isomerase ERp57 targets and modulates the lectin pathway of complement activation. J Biol Chem. 2019 03 29; 294(13):4878-4888. PMID: 30670593.
    Citations:    Fields:    
  4. Eriksson O, Stopa J, Furie B. Identification of PDI Substrates by Mechanism-Based Kinetic Trapping. Methods Mol Biol. 2019; 1967:165-182. PMID: 31069770.
    Citations:    
  5. Bekendam RH, Iyu D, Passam F, Stopa JD, De Ceunynck K, Muse O, Bendapudi PK, Garnier CL, Gopal S, Crescence L, Chiu J, Furie B, Panicot-Dubois L, Hogg PJ, Dubois C, Flaumenhaft R. Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation. J Thromb Haemost. 2018 11; 16(11):2322-2335. PMID: 30207066.
    Citations:    Fields:    
  6. Sharda A, Furie B. Regulatory role of thiol isomerases in thrombus formation. Expert Rev Hematol. 2018 05; 11(5):437-448. PMID: 29542339.
    Citations:    Fields:    
  7. Peng S, Xue G, Gong L, Fang C, Chen J, Yuan C, Chen Z, Yao L, Furie B, Huang M. A long-acting PAI-1 inhibitor reduces thrombus formation. Thromb Haemost. 2017 06 28; 117(7):1338-1347. PMID: 28405670.
    Citations:    Fields:    Translation:HumansAnimals
  8. Stopa JD, Baker KM, Grover SP, Flaumenhaft R, Furie B. Kinetic-based trapping by intervening sequence variants of the active sites of protein-disulfide isomerase identifies platelet protein substrates. J Biol Chem. 2017 06 02; 292(22):9063-9074. PMID: 28364042.
    Citations: 3     Fields:    Translation:HumansCells
  9. Bowley SR, Fang C, Merrill-Skoloff G, Furie BC, Furie B. Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation. Nat Commun. 2017 02 20; 8:14151. PMID: 28218242.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  10. Stopa JD, Neuberg D, Puligandla M, Furie B, Flaumenhaft R, Zwicker JI. Protein disulfide isomerase inhibition blocks thrombin generation in humans by interfering with platelet factor V activation. JCI Insight. 2017 01 12; 2(1):e89373. PMID: 28097231.
    Citations: 6     Fields:    
  11. Bekendam RH, Bendapudi PK, Lin L, Nag PP, Pu J, Kennedy DR, Feldenzer A, Chiu J, Cook KM, Furie B, Huang M, Hogg PJ, Flaumenhaft R. A substrate-driven allosteric switch that enhances PDI catalytic activity. Nat Commun. 2016 08 30; 7:12579. PMID: 27573496.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  12. Flaumenhaft R, Furie B. Vascular thiol isomerases. Blood. 2016 08 18; 128(7):893-901. PMID: 27357699.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  13. Gong L, Proulle V, Fang C, Hong Z, Lin Z, Liu M, Xue G, Yuan C, Lin L, Furie B, Flaumenhaft R, Andreasen P, Furie B, Huang M. A specific plasminogen activator inhibitor-1 antagonist derived from inactivated urokinase. J Cell Mol Med. 2016 10; 20(10):1851-60. PMID: 27197780.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  14. Simeoni I, Stephens JC, Hu F, Deevi SV, Megy K, Bariana TK, Lentaigne C, Schulman S, Sivapalaratnam S, Vries MJ, Westbury SK, Greene D, Papadia S, Alessi MC, Attwood AP, Ballmaier M, Baynam G, Bermejo E, Bertoli M, Bray PF, Bury L, Cattaneo M, Collins P, Daugherty LC, Favier R, French DL, Furie B, Gattens M, Germeshausen M, Ghevaert C, Goodeve AC, Guerrero JA, Hampshire DJ, Hart DP, Heemskerk JW, Henskens YM, Hill M, Hogg N, Jolley JD, Kahr WH, Kelly AM, Kerr R, Kostadima M, Kunishima S, Lambert MP, Liesner R, López JA, Mapeta RP, Mathias M, Millar CM, Nathwani A, Neerman-Arbez M, Nurden AT, Nurden P, Othman M, Peerlinck K, Perry DJ, Poudel P, Reitsma P, Rondina MT, Smethurst PA, Stevenson W, Szkotak A, Tuna S, van Geet C, Whitehorn D, Wilcox DA, Zhang B, Revel-Vilk S, Gresele P, Bellissimo DB, Penkett CJ, Laffan MA, Mumford AD, Rendon A, Gomez K, Freson K, Ouwehand WH, Turro E. A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders. Blood. 2016 06 09; 127(23):2791-803. PMID: 27084890.
    Citations: 21     Fields:    Translation:Humans
  15. Schulman S, Bendapudi P, Sharda A, Chen V, Bellido-Martin L, Jasuja R, Furie BC, Flaumenhaft R, Furie B. Extracellular Thiol Isomerases and Their Role in Thrombus Formation. Antioxid Redox Signal. 2016 Jan 01; 24(1):1-15. PMID: 26467859.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  16. Lin L, Gopal S, Sharda A, Passam F, Bowley SR, Stopa J, Xue G, Yuan C, Furie BC, Flaumenhaft R, Huang M, Furie B. Quercetin-3-rutinoside Inhibits Protein Disulfide Isomerase by Binding to Its b'x Domain. J Biol Chem. 2015 Sep 25; 290(39):23543-52. PMID: 26240139.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  17. Westbury SK, Turro E, Greene D, Lentaigne C, Kelly AM, Bariana TK, Simeoni I, Pillois X, Attwood A, Austin S, Jansen SB, Bakchoul T, Crisp-Hihn A, Erber WN, Favier R, Foad N, Gattens M, Jolley JD, Liesner R, Meacham S, Millar CM, Nurden AT, Peerlinck K, Perry DJ, Poudel P, Schulman S, Schulze H, Stephens JC, Furie B, Robinson PN, van Geet C, Rendon A, Gomez K, Laffan MA, Lambert MP, Nurden P, Ouwehand WH, Richardson S, Mumford AD, Freson K. Human phenotype ontology annotation and cluster analysis to unravel genetic defects in 707 cases with unexplained bleeding and platelet disorders. Genome Med. 2015; 7(1):36. PMID: 25949529.
    Citations: 23     Fields:    
  18. Landeta C, Blazyk JL, Hatahet F, Meehan BM, Eser M, Myrick A, Bronstain L, Minami S, Arnold H, Ke N, Rubin EJ, Furie BC, Furie B, Beckwith J, Dutton R, Boyd D. Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria. Nat Chem Biol. 2015 Apr; 11(4):292-8. PMID: 25686372.
    Citations: 8     Fields:    Translation:Cells
  19. Passam FH, Lin L, Gopal S, Stopa JD, Bellido-Martin L, Huang M, Furie BC, Furie B. Both platelet- and endothelial cell-derived ERp5 support thrombus formation in a laser-induced mouse model of thrombosis. Blood. 2015 Apr 02; 125(14):2276-85. PMID: 25624318.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  20. Sharda A, Kim SH, Jasuja R, Gopal S, Flaumenhaft R, Furie BC, Furie B. Defective PDI release from platelets and endothelial cells impairs thrombus formation in Hermansky-Pudlak syndrome. Blood. 2015 Mar 05; 125(10):1633-42. PMID: 25593336.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  21. Schulman S, Furie B. How I treat poisoning with vitamin K antagonists. Blood. 2015 Jan 15; 125(3):438-42. PMID: 25377783.
    Citations: 4     Fields:    Translation:Humans
  22. Flaumenhaft R, Furie B, Zwicker JI. Therapeutic implications of protein disulfide isomerase inhibition in thrombotic disease. Arterioscler Thromb Vasc Biol. 2015 Jan; 35(1):16-23. PMID: 25104801.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  23. Proulle V, Furie RA, Merrill-Skoloff G, Furie BC, Furie B. Platelets are required for enhanced activation of the endothelium and fibrinogen in a mouse thrombosis model of APS. Blood. 2014 Jul 24; 124(4):611-22. PMID: 24825863.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  24. Furie B, Flaumenhaft R. Thiol isomerases in thrombus formation. Circ Res. 2014 Mar 28; 114(7):1162-73. PMID: 24677236.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  25. Furie B. Do pharmacogenetics have a role in the dosing of vitamin K antagonists? N Engl J Med. 2013 Dec 12; 369(24):2345-6. PMID: 24251364.
    Citations: 19     Fields:    Translation:Humans
  26. Zwicker JI, Liebman HA, Bauer KA, Caughey T, Campigotto F, Rosovsky R, Mantha S, Kessler CM, Eneman J, Raghavan V, Lenz HJ, Bullock A, Buchbinder E, Neuberg D, Furie B. Prediction and prevention of thromboembolic events with enoxaparin in cancer patients with elevated tissue factor-bearing microparticles: a randomized-controlled phase II trial (the Microtec study). Br J Haematol. 2013 Feb; 160(4):530-7. PMID: 23240761.
    Citations: 16     Fields:    Translation:HumansCellsCTClinical Trials
  27. Furie B, Furie BC. Formation of the clot. Thromb Res. 2012 Oct; 130 Suppl 1:S44-6. PMID: 23026660.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  28. Fuster V, Bhatt DL, Califf RM, Michelson AD, Sabatine MS, Angiolillo DJ, Bates ER, Cohen DJ, Coller BS, Furie B, Hulot JS, Mann KG, Mega JL, Musunuru K, O'Donnell CJ, Price MJ, Schneider DJ, Simon DI, Weitz JI, Williams MS, Hoots WK, Rosenberg YD, Hasan AA. Guided antithrombotic therapy: current status and future research direction: report on a National Heart, Lung and Blood Institute working group. Circulation. 2012 Sep 25; 126(13):1645-62. PMID: 23008471.
    Citations: 7     Fields:    Translation:Humans
  29. Cho J, Kennedy DR, Lin L, Huang M, Merrill-Skoloff G, Furie BC, Furie B. Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of ß3 integrins. Blood. 2012 Jul 19; 120(3):647-55. PMID: 22653978.
    Citations: 37     Fields:    Translation:AnimalsCells
  30. Jasuja R, Passam FH, Kennedy DR, Kim SH, van Hessem L, Lin L, Bowley SR, Joshi SS, Dilks JR, Furie B, Furie BC, Flaumenhaft R. Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents. J Clin Invest. 2012 Jun; 122(6):2104-13. PMID: 22565308.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  31. Weitz IC, Razavi P, Rochanda L, Zwicker J, Furie B, Manly D, Mackman N, Green R, Liebman HA. Eculizumab therapy results in rapid and sustained decreases in markers of thrombin generation and inflammation in patients with PNH independent of its effects on hemolysis and microparticle formation. Thromb Res. 2012 Sep; 130(3):361-8. PMID: 22542362.
    Citations: 17     Fields:    Translation:HumansCells
  32. Owens AP, Passam FH, Antoniak S, Marshall SM, McDaniel AL, Rudel L, Williams JC, Hubbard BK, Dutton JA, Wang J, Tobias PS, Curtiss LK, Daugherty A, Kirchhofer D, Luyendyk JP, Moriarty PM, Nagarajan S, Furie BC, Furie B, Johns DG, Temel RE, Mackman N. Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin. J Clin Invest. 2012 Feb; 122(2):558-68. PMID: 22214850.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  33. Zwicker JI, Lacroix R, Dignat-George F, Furie BC, Furie B. Measurement of platelet microparticles. Methods Mol Biol. 2012; 788:127-39. PMID: 22130705.
    Citations: 7     Fields:    Translation:HumansCells
  34. Kroh HK, Panizzi P, Tchaikovski S, Baird TR, Wei N, Krishnaswamy S, Tans G, Rosing J, Furie B, Furie BC, Bock PE. Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo. J Biol Chem. 2011 Jul 01; 286(26):23345-56. PMID: 21531712.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  35. Zwicker JI, Trenor CC, Furie BC, Furie B. Tissue factor-bearing microparticles and thrombus formation. Arterioscler Thromb Vasc Biol. 2011 Apr; 31(4):728-33. PMID: 21252066.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  36. Arad A, Proulle V, Furie RA, Furie BC, Furie B. ß2-Glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model. Blood. 2011 Mar 24; 117(12):3453-9. PMID: 21245481.
    Citations: 26     Fields:    Translation:HumansAnimals
  37. Lin Z, Jiang L, Yuan C, Jensen JK, Zhang X, Luo Z, Furie BC, Furie B, Andreasen PA, Huang M. Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1. J Biol Chem. 2011 Mar 04; 286(9):7027-32. PMID: 21199867.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  38. Atkinson BT, Jasuja R, Chen VM, Nandivada P, Furie B, Furie BC. Laser-induced endothelial cell activation supports fibrin formation. Blood. 2010 Nov 25; 116(22):4675-83. PMID: 20675401.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  39. Jasuja R, Furie B, Furie BC. Endothelium-derived but not platelet-derived protein disulfide isomerase is required for thrombus formation in vivo. Blood. 2010 Nov 25; 116(22):4665-74. PMID: 20668226.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  40. Lu SX, Holland AM, Na IK, Terwey TH, Alpdogan O, Bautista JL, Smith OM, Suh D, King C, Kochman A, Hubbard VM, Rao UK, Yim N, Liu C, Laga AC, Murphy G, Jenq RR, Zakrzewski JL, Penack O, Dykstra L, Bampoe K, Perez L, Furie B, Furie B, van den Brink MR. Absence of P-selectin in recipients of allogeneic bone marrow transplantation ameliorates experimental graft-versus-host disease. J Immunol. 2010 Aug 01; 185(3):1912-9. PMID: 20622117.
    Citations: 7     Fields:    Translation:AnimalsCells
  41. Liu Z, Lin L, Yuan C, Nicolaes GA, Chen L, Meehan EJ, Furie B, Furie B, Huang M. Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. J Biol Chem. 2010 Mar 19; 285(12):8824-9. PMID: 20089867.
    Citations: 15     Fields:    Translation:HumansCells
  42. Barthel SR, Wiese GK, Cho J, Opperman MJ, Hays DL, Siddiqui J, Pienta KJ, Furie B, Dimitroff CJ. Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19491-6. PMID: 19889975.
    Citations: 51     Fields:    Translation:Humans
  43. Zwicker JI, Liebman HA, Neuberg D, Lacroix R, Bauer KA, Furie BC, Furie B. Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy. Clin Cancer Res. 2009 Nov 15; 15(22):6830-40. PMID: 19861441.
    Citations: 101     Fields:    Translation:Humans
  44. Furie B. Pathogenesis of thrombosis. Hematology Am Soc Hematol Educ Program. 2009; 255-8. PMID: 20008207.
    Citations: 12     Fields:    Translation:AnimalsCells
  45. Furie B, Furie BC. Mechanisms of thrombus formation. N Engl J Med. 2008 Aug 28; 359(9):938-49. PMID: 18753650.
    Citations: 282     Fields:    Translation:HumansAnimals
  46. Ngo JC, Huang M, Roth DA, Furie BC, Furie B. Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex. Structure. 2008 Apr; 16(4):597-606. PMID: 18400180.
    Citations: 68     Fields:    Translation:HumansCells
  47. Huai Q, Zhou A, Lin L, Mazar AP, Parry GC, Callahan J, Shaw DE, Furie B, Furie BC, Huang M. Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes. Nat Struct Mol Biol. 2008 Apr; 15(4):422-3. PMID: 18376415.
    Citations: 35     Fields:    Translation:HumansCells
  48. Cho J, Furie BC, Coughlin SR, Furie B. A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. J Clin Invest. 2008 Mar; 118(3):1123-31. PMID: 18292814.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  49. Panicot-Dubois L, Thomas GM, Furie BC, Furie B, Lombardo D, Dubois C. Bile salt-dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans. J Clin Invest. 2007 Dec; 117(12):3708-19. PMID: 18037996.
    Citations: 12     Fields:    Translation:AnimalsCells
  50. Lin L, Huai Q, Huang M, Furie B, Furie BC. Crystal structure of the bovine lactadherin C2 domain, a membrane binding motif, shows similarity to the C2 domains of factor V and factor VIII. J Mol Biol. 2007 Aug 17; 371(3):717-24. PMID: 17583728.
    Citations: 14     Fields:    Translation:AnimalsCells
  51. Dubois C, Panicot-Dubois L, Gainor JF, Furie BC, Furie B. Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model. J Clin Invest. 2007 Apr; 117(4):953-60. PMID: 17380206.
    Citations: 47     Fields:    Translation:AnimalsCells
  52. Zhu A, Sun H, Raymond RM, Furie BC, Furie B, Bronstein M, Kaufman RJ, Westrick R, Ginsburg D. Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase. Blood. 2007 Jun 15; 109(12):5270-5. PMID: 17327402.
    Citations: 17     Fields:    Translation:Animals
  53. Zwicker JI, Furie BC, Furie B. Cancer-associated thrombosis. Crit Rev Oncol Hematol. 2007 May; 62(2):126-36. PMID: 17293122.
    Citations: 32     Fields:    Translation:HumansAnimals
  54. Harakawa N, Shigeta A, Wato M, Merrill-Skoloff G, Furie BC, Furie B, Okazaki T, Domae N, Miyasaka M, Hirata T. P-selectin glycoprotein ligand-1 mediates L-selectin-independent leukocyte rolling in high endothelial venules of peripheral lymph nodes. Int Immunol. 2007 Mar; 19(3):321-9. PMID: 17267415.
    Citations: 4     Fields:    Translation:AnimalsCells
  55. Vandendries ER, Hamilton JR, Coughlin SR, Furie B, Furie BC. Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):288-92. PMID: 17190826.
    Citations: 63     Fields:    Translation:AnimalsCells
  56. Hansson K, Thämlitz AM, Furie B, Furie BC, Stenflo J. A single gamma-carboxyglutamic acid residue in a novel cysteine-rich secretory protein without propeptide. Biochemistry. 2006 Oct 24; 45(42):12828-39. PMID: 17042501.
    Citations: 2     Fields:    Translation:AnimalsCells
  57. Czerwiec E, Kalume DE, Roepstorff P, Hambe B, Furie B, Furie BC, Stenflo J. Novel gamma-carboxyglutamic acid-containing peptides from the venom of Conus textile. FEBS J. 2006 Jun; 273(12):2779-88. PMID: 16817904.
    Citations: 11     Fields:    Translation:AnimalsCells
  58. Furie BC, Furie B. Tissue factor pathway vs. collagen pathway for in vivo platelet activation. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):135-8. PMID: 16513378.
    Citations: 1     Fields:    Translation:HumansAnimals
  59. Furie B, Furie BC. Cancer-associated thrombosis. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):177-81. PMID: 16490369.
    Citations: 12     Fields:    Translation:HumansCells
  60. Huai Q, Mazar AP, Kuo A, Parry GC, Shaw DE, Callahan J, Li Y, Yuan C, Bian C, Chen L, Furie B, Furie BC, Cines DB, Huang M. Structure of human urokinase plasminogen activator in complex with its receptor. Science. 2006 Feb 03; 311(5761):656-9. PMID: 16456079.
    Citations: 65     Fields:    Translation:HumansCells
  61. Dubois C, Panicot-Dubois L, Merrill-Skoloff G, Furie B, Furie BC. Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo. Blood. 2006 May 15; 107(10):3902-6. PMID: 16455953.
    Citations: 66     Fields:    Translation:Animals
  62. Furie B, Furie BC. Thrombus formation in a living mouse. Pathophysiol Haemost Thromb. 2006; 35(1-2):1-4. PMID: 16855338.
    Citations: 1     Fields:    Translation:Animals
  63. Furie B, Furie BC. Thrombus formation in vivo. J Clin Invest. 2005 Dec; 115(12):3355-62. PMID: 16322780.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  64. Gross PL, Furie BC, Merrill-Skoloff G, Chou J, Furie B. Leukocyte-versus microparticle-mediated tissue factor transfer during arteriolar thrombus development. J Leukoc Biol. 2005 Dec; 78(6):1318-26. PMID: 16204641.
    Citations: 37     Fields:    Translation:AnimalsCells
  65. Falati S, Patil S, Gross PL, Stapleton M, Merrill-Skoloff G, Barrett NE, Pixton KL, Weiler H, Cooley B, Newman DK, Newman PJ, Furie BC, Furie B, Gibbins JM. Platelet PECAM-1 inhibits thrombus formation in vivo. Blood. 2006 Jan 15; 107(2):535-41. PMID: 16166583.
    Citations: 48     Fields:    Translation:AnimalsCells
  66. Arias-Salgado EG, Haj F, Dubois C, Moran B, Kasirer-Friede A, Furie BC, Furie B, Neel BG, Shattil SJ. PTP-1B is an essential positive regulator of platelet integrin signaling. J Cell Biol. 2005 Aug 29; 170(5):837-45. PMID: 16115959.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  67. Engelhardt B, Kempe B, Merfeld-Clauss S, Laschinger M, Furie B, Wild MK, Vestweber D. P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice. J Immunol. 2005 Jul 15; 175(2):1267-75. PMID: 16002731.
    Citations: 17     Fields:    Translation:AnimalsCells
  68. Brown MA, Begley GS, Czerwiec E, Stenberg LM, Jacobs M, Kalume DE, Roepstorff P, Stenflo J, Furie BC, Furie B. Precursors of novel Gla-containing conotoxins contain a carboxy-terminal recognition site that directs gamma-carboxylation. Biochemistry. 2005 Jun 28; 44(25):9150-9. PMID: 15966739.
    Citations: 11     Fields:    Translation:AnimalsCells
  69. Furie B. P-selectin and blood coagulation: it's not only about inflammation any more. Arterioscler Thromb Vasc Biol. 2005 May; 25(5):877-8. PMID: 15863716.
    Citations:    Fields:    Translation:HumansAnimals
  70. Sim D, Flaumenhaft R, Furie B, Furie B. Interactions of platelets, blood-borne tissue factor, and fibrin during arteriolar thrombus formation in vivo. Microcirculation. 2005 Apr-May; 12(3):301-11. PMID: 15814438.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  71. Sathish JG, Falati S, Croce K, Crump C, Furie BC, Furie B, Poole AW. Antibody cross-linking of human platelet P-selectin induces calcium entry by a mechanism dependent upon Fcgamma receptor IIA. Thromb Haemost. 2004 Sep; 92(3):598-605. PMID: 15351857.
    Citations: 1     Fields:    Translation:HumansCells
  72. Vandendries ER, Furie BC, Furie B. Role of P-selectin and PSGL-1 in coagulation and thrombosis. Thromb Haemost. 2004 Sep; 92(3):459-66. PMID: 15351841.
    Citations: 41     Fields:    Translation:HumansCells
  73. Chou J, Mackman N, Merrill-Skoloff G, Pedersen B, Furie BC, Furie B. Hematopoietic cell-derived microparticle tissue factor contributes to fibrin formation during thrombus propagation. Blood. 2004 Nov 15; 104(10):3190-7. PMID: 15280200.
    Citations: 85     Fields:    Translation:AnimalsCells
  74. Hansson K, Furie B, Furie BC, Stenflo J. Isolation and characterization of three novel Gla-containing Conus marmoreus venom peptides, one with a novel cysteine pattern. Biochem Biophys Res Commun. 2004 Jul 09; 319(4):1081-7. PMID: 15194478.
    Citations: 8     Fields:    Translation:AnimalsCells
  75. Schenone M, Furie BC, Furie B. The blood coagulation cascade. Curr Opin Hematol. 2004 Jul; 11(4):272-7. PMID: 15314527.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  76. Grant MA, Hansson K, Furie BC, Furie B, Stenflo J, Rigby AC. The metal-free and calcium-bound structures of a gamma-carboxyglutamic acid-containing contryphan from Conus marmoreus, glacontryphan-M. J Biol Chem. 2004 Jul 30; 279(31):32464-73. PMID: 15155731.
    Citations: 3     Fields:    Translation:AnimalsCells
  77. Hansson K, Ma X, Eliasson L, Czerwiec E, Furie B, Furie BC, Rorsman P, Stenflo J. The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus. J Biol Chem. 2004 Jul 30; 279(31):32453-63. PMID: 15155730.
    Citations: 10     Fields:    Translation:AnimalsCells
  78. Furie B, Furie BC. Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation. Trends Mol Med. 2004 Apr; 10(4):171-8. PMID: 15059608.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  79. Huang M, Furie BC, Furie B. Crystal structure of the calcium-stabilized human factor IX Gla domain bound to a conformation-specific anti-factor IX antibody. J Biol Chem. 2004 Apr 02; 279(14):14338-46. PMID: 14722079.
    Citations: 16     Fields:    Translation:HumansCells
  80. Celi A, Lorenzet R, Furie BC, Furie B. Microparticles and a P-selectin-mediated pathway of blood coagulation. Dis Markers. 2004; 20(6):347-52. PMID: 15665395.
    Citations: 5     Fields:    Translation:HumansAnimals
  81. Falati S, Gross PL, Merrill-Skoloff G, Sim D, Flaumenhaft R, Celi A, Furie BC, Furie B. In vivo models of platelet function and thrombosis: study of real-time thrombus formation. Methods Mol Biol. 2004; 272:187-97. PMID: 15226545.
    Citations: 12     Fields:    Translation:AnimalsCells
  82. Tchernychev B, Furie B, Furie BC. Peritoneal macrophages express both P-selectin and PSGL-1. J Cell Biol. 2003 Dec 08; 163(5):1145-55. PMID: 14662752.
    Citations: 12     Fields:    Translation:AnimalsCells
  83. Sim DS, Merrill-Skoloff G, Furie BC, Furie B, Flaumenhaft R. Initial accumulation of platelets during arterial thrombus formation in vivo is inhibited by elevation of basal cAMP levels. Blood. 2004 Mar 15; 103(6):2127-34. PMID: 14645013.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  84. Huang M, Rigby AC, Morelli X, Grant MA, Huang G, Furie B, Seaton B, Furie BC. Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins. Nat Struct Biol. 2003 Sep; 10(9):751-6. PMID: 12923575.
    Citations: 64     Fields:    Translation:AnimalsCells
  85. Li J, Lin JC, Wang H, Peterson JW, Furie BC, Furie B, Booth SL, Volpe JJ, Rosenberg PA. Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons. J Neurosci. 2003 Jul 02; 23(13):5816-26. PMID: 12843286.
    Citations: 43     Fields:    Translation:AnimalsCells
  86. Falati S, Liu Q, Gross P, Merrill-Skoloff G, Chou J, Vandendries E, Celi A, Croce K, Furie BC, Furie B. Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. J Exp Med. 2003 Jun 02; 197(11):1585-98. PMID: 12782720.
    Citations: 157     Fields:    Translation:Animals
  87. Blostein MD, Furie BC, Rajotte I, Furie B. The Gla domain of factor IXa binds to factor VIIIa in the tenase complex. J Biol Chem. 2003 Aug 15; 278(33):31297-302. PMID: 12782629.
    Citations: 9     Fields:    Translation:HumansCells
  88. Katayama Y, Hidalgo A, Furie BC, Vestweber D, Furie B, Frenette PS. PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and alpha4 integrin. Blood. 2003 Sep 15; 102(6):2060-7. PMID: 12763924.
    Citations: 48     Fields:    Translation:AnimalsCells
  89. Furie B, Furie BC. Real time in vivo imaging of tissue factor-induced thrombus formation. Pathophysiol Haemost Thromb. 2003; 33 Suppl 1:26-7. PMID: 12954996.
    Citations: 1     Fields:    Translation:Animals
  90. Czerwiec E, Begley GS, Bronstein M, Stenflo J, Taylor K, Furie BC, Furie B. Expression and characterization of recombinant vitamin K-dependent gamma-glutamyl carboxylase from an invertebrate, Conus textile. Eur J Biochem. 2002 Dec; 269(24):6162-72. PMID: 12473112.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  91. Hirata T, Furie BC, Furie B. P-, E-, and L-selectin mediate migration of activated CD8+ T lymphocytes into inflamed skin. J Immunol. 2002 Oct 15; 169(8):4307-13. PMID: 12370362.
    Citations: 22     Fields:    Translation:AnimalsCells
  92. Falati S, Gross P, Merrill-Skoloff G, Furie BC, Furie B. Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse. Nat Med. 2002 Oct; 8(10):1175-81. PMID: 12244306.
    Citations: 174     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.