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Gerald Bryan Pier, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. D18EQ-015 (Noah Cohen) Mar 1, 2018 - Feb 29, 2020
    Morris Animal Foundation
    Efficacy of Maternal Immunization Against PNAG to Protect Newborn Foals Against Rhodococcus equi Pneumonia
    Role Description: Our objective is to develop a vaccine that can protect foals against pneumonia caused by natural infection with R. equi under field conditions. Our 1st hypothesis (H1) is that maternal vaccination against PNAG can protect foals against intrabronchial infection with virulent R. equi during the 1st week of life. Our 2nd hypothesis (H2) is that this protection is correlated with the transfer of antibodies against PNAG in plasma that fix complement and mediate opsonophagocytic killing of R. equi in macrophages.
    Role: Co-investigator
  2. PIER16GO (gerald Pier) Apr 1, 2016 - Mar 31, 2018
    Cystic Fibrosis Foundation
    Identification of novel P. aeruginosa vaccine antigens for CF
    Role Description: While there have been exciting advances in the treatment of CF in the past few years, chronic lung infections remain a vexing problem that make up the one of the most difficult aspects of care for patients. Vaccines to prevent the infections, particularly for the organism known as Pseudomonas aeruginosa, could greatly improve overall health and protect against lung damage and respiratory problems. However, discovering vaccines is an inexact science, with most of the work done to date following an empiric process with a lot of trial and error, and so, far, in regard to P. aeruginosa, no success. Our research proposal will use the tools of modern biology and genetics to try to expedite the process of discovering antigens by allowing the immune system of an immunized animal to determine which components of the microbe make the best target antigens. After using techniques of rapid and high-level sequencing of DNA and immunology, specific candidate vaccines will be prepared and used to immunize mice to see if the candidate does, indeed, elicit an immune response that protects against lung infection. With the candidates identified it will then be possible to further develop them for human testing, determine if CF patients lack immunity to the vaccine, thus explaining their susceptibility to infection, with the ultimate goal to alter the course of lung disease via successful vaccination.
    Role: PI
  3. (Noah Cohen) Jan 1, 2016 - Dec 31, 2017
    Grayson Jockey Club
    A Novel Vaccine Against Equine Strangles
    Role Description: Objectives: Infectious diseases are leading causes of morbidity and mortality for horses worldwide. Streptococcus equi subspecies equi (SE) causes a highly contagious disease com-monly known as strangles that remains the most frequently diagnosed infectious disease of horses.14,46 Currently-available vaccines have limitations in safety and efficacy. Great need ex-ists for novel approaches that can generate protective immunity against SE. Bacterial surface polysaccharides have been demonstrated to be highly effective as vaccines against multiple bacterial pathogens, and the Pier laboratory has discovered that a conserved one of these, termed poly-N-acetyl glucosamine (PNAG), can be chemically modified to generate protective immunity.6,10 Antibodies against naturally-occurring PNAG are not protective on their own,22,35,36 but by chemically altering the PNAG molecule a glycoform is produced that elicits antibodies that recognize native PNAG and provide protection.10,26 We will evaluate the safety, immuno-genicity and efficacy of a PNAG-based oligosaccharide conjugated to tetanus toxoid (5GlcNH2-TT) vaccine10 to protect horses against strangles (SE-induced upper respiratory tract disease) by carrying out the following specific aims and hypotheses:
    Role: Co-investigator
  4. R01EY016144 (PIER, GERALD B) Jan 1, 2005 - Aug 31, 2019
    Pathogenesis of microbial anterior eye diseases
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Cywes-Bentley C, Rocha JN, Bordin AI, Vinacur M, Rehman S, Zaidi TS, Meyer M, Anthony S, Lambert M, Vlock DR, Giguère S, Cohen ND, Pier GB. Antibody to Poly-N-acetyl glucosamine provides protection against intracellular pathogens: Mechanism of action and validation in horse foals challenged with Rhodococcus equi. PLoS Pathog. 2018 Jul; 14(7):e1007160. PMID: 30024986.
    View in: PubMed
  2. Zaidi TS, Zaidi T, Pier GB. Antibodies to Conserved Surface Polysaccharides Protect Mice Against Bacterial Conjunctivitis. Invest Ophthalmol Vis Sci. 2018 May 01; 59(6):2512-2519. PMID: 29847658.
    View in: PubMed
  3. Little DJ, Pfoh R, Le Mauff F, Bamford NC, Notte C, Baker P, Guragain M, Robinson H, Pier GB, Nitz M, Deora R, Sheppard DC, Howell PL. PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-ß(1,6)-N-acetylglucosamine and can disrupt bacterial biofilms. PLoS Pathog. 2018 04; 14(4):e1006998. PMID: 29684093.
    View in: PubMed
  4. Stevenson TC, Cywes-Bentley C, Moeller TD, Weyant KB, Putnam D, Chang YF, Jones BD, Pier GB, DeLisa MP. Immunization with outer membrane vesicles displaying conserved surface polysaccharide antigen elicits broadly antimicrobial antibodies. Proc Natl Acad Sci U S A. 2018 04 03; 115(14):E3106-E3115. PMID: 29555731.
    View in: PubMed
  5. Soliman C, Walduck AK, Yuriev E, Richards JS, Cywes-Bentley C, Pier GB, Ramsland PA. Structural basis for antibody targeting of the broadly expressed microbial polysaccharide poly-N-acetylglucosamine. J Biol Chem. 2018 Apr 06; 293(14):5079-5089. PMID: 29449370.
    View in: PubMed
  6. van Dissel D, Willemse J, Zacchetti B, Claessen D, Pier GB, van Wezel GP. Production of poly-ß-1,6-N-acetylglucosamine by MatAB is required for hyphal aggregation and hydrophilic surface adhesion by Streptomyces. Microb Cell. 2018 Feb 12; 5(6):269-279. PMID: 29850464.
    View in: PubMed
  7. Sanchez-Larrayoz AF, Elhosseiny NM, Chevrette MG, Fu Y, Giunta P, Spallanzani RG, Ravi K, Pier GB, Lory S, Maira-Litrán T. Complexity of Complement Resistance Factors Expressed by Acinetobacter baumannii Needed for Survival in Human Serum. J Immunol. 2017 10 15; 199(8):2803-2814. PMID: 28855313.
    View in: PubMed
  8. Shanmugam M, Oyeniyi AO, Parthiban C, Gujjarlapudi SK, Pier GB, Ramasubbu N. Role of de-N-acetylase PgaB from Aggregatibacter actinomycetemcomitans in exopolysaccharide export in biofilm mode of growth. Mol Oral Microbiol. 2017 12; 32(6):500-510. PMID: 28548373.
    View in: PubMed
  9. Roux D, Weatherholt M, Clark B, Gadjeva M, Renaud D, Scott D, Skurnik D, Priebe GP, Pier G, Gerard C, Yoder-Himes DR. Immune Recognition of the Epidemic Cystic Fibrosis Pathogen Burkholderia dolosa. Infect Immun. 2017 06; 85(6). PMID: 28348057.
    View in: PubMed
  10. Yu L, Hisatsune J, Hayashi I, Tatsukawa N, Sato'o Y, Mizumachi E, Kato F, Hirakawa H, Pier GB, Sugai M. A Novel Repressor of the ica Locus Discovered in Clinically Isolated Super-Biofilm-Elaborating Staphylococcus aureus. MBio. 2017 01 31; 8(1). PMID: 28143981.
    View in: PubMed
  11. Søe NH, Jensen NV, Jensen AL, Koch J, Poulsen SS, Pier GB, Johansen HK. Active and Passive Immunization Against Staphylococcus aureus Periprosthetic Osteomyelitis in Rats. In Vivo. 2017 01 02; 31(1):45-50. PMID: 28064219.
    View in: PubMed
  12. Zhao G, Zaidi TS, Bozkurt-Guzel C, Zaidi TH, Lederer JA, Priebe GP, Pier GB. Efficacy of Antibody to PNAG Against Keratitis Caused by Fungal Pathogens. Invest Ophthalmol Vis Sci. 2016 12 01; 57(15):6797-6804. PMID: 28002842.
    View in: PubMed
  13. França A, Pérez-Cabezas B, Correia A, Pier GB, Cerca N, Vilanova M. Staphylococcus epidermidis Biofilm-Released Cells Induce a Prompt and More Marked In vivo Inflammatory-Type Response than Planktonic or Biofilm Cells. Front Microbiol. 2016; 7:1530. PMID: 27729907.
    View in: PubMed
  14. Ferreirinha P, Pérez-Cabezas B, Correia A, Miyazawa B, França A, Carvalhais V, Faustino A, Cordeiro-da-Silva A, Teixeira L, Pier GB, Cerca N, Vilanova M. Poly-N-Acetylglucosamine Production by Staphylococcus epidermidis Cells Increases Their In Vivo Proinflammatory Effect. Infect Immun. 2016 10; 84(10):2933-43. PMID: 27481237.
    View in: PubMed
  15. França A, Pier GB, Vilanova M, Cerca N. Transcriptomic Analysis of Staphylococcus epidermidis Biofilm-Released Cells upon Interaction with Human Blood Circulating Immune Cells and Soluble Factors. Front Microbiol. 2016; 7:1143. PMID: 27493645; PMCID: PMC4955375.
  16. Guillard T, Pons S, Roux D, Pier GB, Skurnik D. Antibiotic resistance and virulence: Understanding the link and its consequences for prophylaxis and therapy. Bioessays. 2016 07; 38(7):682-93. PMID: 27248008.
    View in: PubMed
  17. Kar S, Arjunaraja S, Akkoyunlu M, Pier GB, Snapper CM. Distinct Mechanisms Underlie Boosted Polysaccharide-Specific IgG Responses Following Secondary Challenge with Intact Gram-Negative versus Gram-Positive Extracellular Bacteria. J Immunol. 2016 06 01; 196(11):4614-21. PMID: 27183619.
    View in: PubMed
  18. França A, Carvalhais V, Vilanova M, Pier GB, Cerca N. Characterization of an in vitro fed-batch model to obtain cells released from S. epidermidis biofilms. AMB Express. 2016 Mar; 6(1):23. PMID: 27001438; PMCID: PMC4801823.
  19. Skurnik D, Cywes-Bentley C, Pier GB. The exceptionally broad-based potential of active and passive vaccination targeting the conserved microbial surface polysaccharide PNAG. Expert Rev Vaccines. 2016 08; 15(8):1041-53. PMID: 26918288.
    View in: PubMed
  20. Song J, Wilhelm CL, Wangdi T, Maira-Litran T, Lee SJ, Raetz M, Sturge CR, Mirpuri J, Pei J, Grishin NV, McSorley SJ, Gewirtz AT, Bäumler AJ, Pier GB, Galán JE, Yarovinsky F. Absence of TLR11 in Mice Does Not Confer Susceptibility to Salmonella Typhi. Cell. 2016 Feb 25; 164(5):827-8. PMID: 26919416.
    View in: PubMed
  21. Skurnik D, Roux D, Pons S, Guillard T, Lu X, Cywes-Bentley C, Pier GB. Extended-spectrum antibodies protective against carbapenemase-producing Enterobacteriaceae. J Antimicrob Chemother. 2016 Apr; 71(4):927-35. PMID: 26747103; PMCID: PMC4790622 [Available on 04/01/17].
  22. Roux D, Pons S, Guillard T, Ricard JD, Pier GB, Skurnik D. Impact of Drug Resistance on Virulence and Fitness of Bacterial Pathogens. Crit Care Med. 2016 Jan; 44(1):e50. PMID: 26672941.
    View in: PubMed
  23. Mellata M, Mitchell NM, Schödel F, Curtiss R, Pier GB. Novel vaccine antigen combinations elicit protective immune responses against Escherichia coli sepsis. Vaccine. 2016 Jan 27; 34(5):656-662. PMID: 26707217; PMCID: PMC4715933 [Available on 01/27/17].
  24. Korneev KV, Arbatsky NP, Molinaro A, Palmigiano A, Shaikhutdinova RZ, Shneider MM, Pier GB, Kondakova AN, Sviriaeva EN, Sturiale L, Garozzo D, Kruglov AA, Nedospasov SA, Drutskaya MS, Knirel YA, Kuprash DV. Structural Relationship of the Lipid A Acyl Groups to Activation of Murine Toll-Like Receptor 4 by Lipopolysaccharides from Pathogenic Strains of Burkholderia mallei, Acinetobacter baumannii, and Pseudomonas aeruginosa. Front Immunol. 2015; 6:595. PMID: 26635809; PMCID: PMC4655328.
  25. Gauguet S, D'Ortona S, Ahnger-Pier K, Duan B, Surana NK, Lu R, Cywes-Bentley C, Gadjeva M, Shan Q, Priebe GP, Pier GB. Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia. Infect Immun. 2015 Oct; 83(10):4003-14. PMID: 26216419; PMCID: PMC4567647.
  26. Roux D, Danilchanka O, Guillard T, Cattoir V, Aschard H, Fu Y, Angoulvant F, Messika J, Ricard JD, Mekalanos JJ, Lory S, Pier GB, Skurnik D. Fitness cost of antibiotic susceptibility during bacterial infection. Sci Transl Med. 2015 Jul 22; 7(297):297ra114. PMID: 26203082.
    View in: PubMed
  27. Roux D, Cywes-Bentley C, Zhang YF, Pons S, Konkol M, Kearns DB, Little DJ, Howell PL, Skurnik D, Pier GB. Identification of Poly-N-acetylglucosamine as a Major Polysaccharide Component of the Bacillus subtilis Biofilm Matrix. J Biol Chem. 2015 Jul 31; 290(31):19261-72. PMID: 26078454; PMCID: PMC4521046.
  28. Carvalhais V, França A, Pier GB, Vilanova M, Cerca N, Vitorino R. Comparative proteomic and transcriptomic profile of Staphylococcus epidermidis biofilms grown in glucose-enriched medium. Talanta. 2015 Jan; 132:705-12. PMID: 25476368.
    View in: PubMed
  29. Cerca F, França A, Pérez-Cabezas B, Carvalhais V, Ribeiro A, Azeredo J, Pier G, Cerca N, Vilanova M. Dormant bacteria within Staphylococcus epidermidis biofilms have low inflammatory properties and maintain tolerance to vancomycin and penicillin after entering planktonic growth. J Med Microbiol. 2014 Oct; 63(Pt 10):1274-83. PMID: 25053799; PMCID: PMC4170483.
  30. Zaidi T, Zaidi T, Cywes-Bentley C, Lu R, Priebe GP, Pier GB. Microbiota-driven immune cellular maturation is essential for antibody-mediated adaptive immunity to Staphylococcus aureus infection in the eye. Infect Immun. 2014 Aug; 82(8):3483-91. PMID: 24914214; PMCID: PMC4136232.
  31. Lu X, Skurnik D, Pozzi C, Roux D, Cywes-Bentley C, Ritchie JM, Munera D, Gening ML, Tsvetkov YE, Nifantiev NE, Waldor MK, Pier GB. A Poly-N-acetylglucosamine-Shiga toxin broad-spectrum conjugate vaccine for Shiga toxin-producing Escherichia coli. MBio. 2014 Mar 25; 5(2):e00974-14. PMID: 24667709; PMCID: PMC3977355.
  32. França A, Carvalhais V, Maira-Litrán T, Vilanova M, Cerca N, Pier G. Alterations in the Staphylococcus epidermidis biofilm transcriptome following interaction with whole human blood. Pathog Dis. 2014 Apr; 70(3):444-8. PMID: 24391077.
    View in: PubMed
  33. Carvalhais V, França A, Cerca F, Vitorino R, Pier GB, Vilanova M, Cerca N. Dormancy within Staphylococcus epidermidis biofilms: a transcriptomic analysis by RNA-seq. Appl Microbiol Biotechnol. 2014 Mar; 98(6):2585-96. PMID: 24504458.
    View in: PubMed
  34. Skurnik D, Roux D, Cattoir V, Danilchanka O, Lu X, Yoder-Himes DR, Han K, Guillard T, Jiang D, Gaultier C, Guerin F, Aschard H, Leclercq R, Mekalanos JJ, Lory S, Pier GB. Enhanced in vivo fitness of carbapenem-resistant oprD mutants of Pseudomonas aeruginosa revealed through high-throughput sequencing. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):20747-52. PMID: 24248354; PMCID: PMC3870709.
  35. Döring G, Bragonzi A, Paroni M, Aktürk FF, Cigana C, Schmidt A, Gilpin D, Heyder S, Born T, Smaczny C, Kohlhäufl M, Wagner TO, Loebinger MR, Bilton D, Tunney MM, Elborn JS, Pier GB, Konstan MW, Ulrich M. BIIL 284 reduces neutrophil numbers but increases P. aeruginosa bacteremia and inflammation in mouse lungs. J Cyst Fibros. 2014 Mar; 13(2):156-63. PMID: 24183915; PMCID: PMC4163938.
  36. Skurnik D, Roux D, Aschard H, Cattoir V, Yoder-Himes D, Lory S, Pier GB. A comprehensive analysis of in vitro and in vivo genetic fitness of Pseudomonas aeruginosa using high-throughput sequencing of transposon libraries. PLoS Pathog. 2013; 9(9):e1003582. PMID: 24039572; PMCID: PMC3764216.
  37. Zaidi T, Zaidi T, Yoong P, Pier GB. Staphylococcus aureus corneal infections: effect of the Panton-Valentine leukocidin (PVL) and antibody to PVL on virulence and pathology. Invest Ophthalmol Vis Sci. 2013 Jul 01; 54(7):4430-8. PMID: 23737477; PMCID: PMC3700385.
  38. Pier GB. Will there ever be a universal Staphylococcus aureus vaccine? Hum Vaccin Immunother. 2013 Sep; 9(9):1865-76. PMID: 23793522; PMCID: PMC3906350.
  39. Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, Deoliveira RB, Garrett WS, Lu X, O'Malley J, Kinzel K, Zaidi T, Rey A, Perrin C, Fichorova RN, Kayatani AK, Maira-Litràn T, Gening ML, Tsvetkov YE, Nifantiev NE, Bakaletz LO, Pelton SI, Golenbock DT, Pier GB. Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2209-18. PMID: 23716675; PMCID: PMC3683766.
  40. França A, Vilanova M, Cerca N, Pier GB. Monoclonal antibody raised against PNAG has variable effects on static S. epidermidis biofilm accumulation in vitro. Int J Biol Sci. 2013; 9(5):518-20. PMID: 23781145; PMCID: PMC3677687.
  41. Py BF, Gonzalez SF, Long K, Kim MS, Kim YA, Zhu H, Yao J, Degauque N, Villet R, Ymele-Leki P, Gadjeva M, Pier GB, Carroll MC, Yuan J. Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity. Immunity. 2013 May 23; 38(5):1063-72. PMID: 23684986; PMCID: PMC3758559.
  42. Babra C, Tiwari JG, Pier G, Thein TH, Sunagar R, Sundareshan S, Isloor S, Hegde NR, de Wet S, Deighton M, Gibson J, Costantino P, Wetherall J, Mukkur T. The persistence of biofilm-associated antibiotic resistance of Staphylococcus aureus isolated from clinical bovine mastitis cases in Australia. Folia Microbiol (Praha). 2013 Nov; 58(6):469-74. PMID: 23446489.
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  43. Søe NH, Jensen NV, Nürnberg BM, Jensen AL, Koch J, Poulsen SS, Pier G, Johansen HK. A novel knee prosthesis model of implant-related osteomyelitis in rats. Acta Orthop. 2013 Feb; 84(1):92-7. PMID: 23409845; PMCID: PMC3584611.
  44. Reidy T, Rittenberg A, Dwyer M, D'Ortona S, Pier G, Gadjeva M. Homotrimeric macrophage migration inhibitory factor (MIF) drives inflammatory responses in the corneal epithelium by promoting caveolin-rich platform assembly in response to infection. J Biol Chem. 2013 Mar 22; 288(12):8269-78. PMID: 23372160; PMCID: PMC3605645.
  45. Kamei A, Wu W, Traficante DC, Koh AY, Van Rooijen N, Pier GB, Priebe GP. Collaboration between macrophages and vaccine-induced CD4+ T cells confers protection against lethal Pseudomonas aeruginosa pneumonia during neutropenia. J Infect Dis. 2013 Jan 01; 207(1):39-49. PMID: 23100569; PMCID: PMC3523801.
  46. Pozzi C, Wilk K, Lee JC, Gening M, Nifantiev N, Pier GB. Opsonic and protective properties of antibodies raised to conjugate vaccines targeting six Staphylococcus aureus antigens. PLoS One. 2012; 7(10):e46648. PMID: 23077517; PMCID: PMC3471903.
  47. Tamang DL, Pirzai W, Priebe GP, Traficante DC, Pier GB, Falck JR, Morisseau C, Hammock BD, McCormick BA, Gronert K, Hurley BP. Hepoxilin A(3) facilitates neutrophilic breach of lipoxygenase-expressing airway epithelial barriers. J Immunol. 2012 Nov 15; 189(10):4960-9. PMID: 23045615; PMCID: PMC3490410.
  48. Maira-Litrán T, Bentancor LV, Bozkurt-Guzel C, O'Malley JM, Cywes-Bentley C, Pier GB. Synthesis and evaluation of a conjugate vaccine composed of Staphylococcus aureus poly-N-acetyl-glucosamine and clumping factor A. PLoS One. 2012; 7(9):e43813. PMID: 22970144; PMCID: PMC3435376.
  49. Roux D, Pier GB, Skurnik D. Magic bullets for the 21st century: the reemergence of immunotherapy for multi- and pan-resistant microbes. J Antimicrob Chemother. 2012 Dec; 67(12):2785-7. PMID: 22899807; PMCID: PMC3695597.
  50. Yoong P, Cywes-Bentley C, Pier GB. Poly-N-acetylglucosamine expression by wild-type Yersinia pestis is maximal at mammalian, not flea, temperatures. MBio. 2012; 3(4):e00217-12. PMID: 22893384; PMCID: PMC3419525.
  51. Komarova BS, Tsvetkov YE, Pier GB, Nifantiev NE. Synthesis of pentasaccharides corresponding to the glycoform II of the outer core region of the Pseudomonas aeruginosa lipopolysaccharide. Carbohydr Res. 2012 Oct 01; 360:56-68. PMID: 22940177.
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  52. Bentancor LV, Routray A, Bozkurt-Guzel C, Camacho-Peiro A, Pier GB, Maira-Litrán T. Evaluation of the trimeric autotransporter Ata as a vaccine candidate against Acinetobacter baumannii infections. Infect Immun. 2012 Oct; 80(10):3381-8. PMID: 22825448; PMCID: PMC3457567.
  53. Skurnik D, Kropec A, Roux D, Theilacker C, Huebner J, Pier GB. Natural antibodies in normal human serum inhibit Staphylococcus aureus capsular polysaccharide vaccine efficacy. Clin Infect Dis. 2012 Nov; 55(9):1188-97. PMID: 22806596; PMCID: PMC3529611.
  54. Zaidi TS, Zaidi T, Pier GB, Priebe GP. Topical neutralization of interleukin-17 during experimental Pseudomonas aeruginosa corneal infection promotes bacterial clearance and reduces pathology. Infect Immun. 2012 Oct; 80(10):3706-12. PMID: 22802348; PMCID: PMC3457570.
  55. Pier GB. The challenges and promises of new therapies for cystic fibrosis. J Exp Med. 2012 Jul 02; 209(7):1235-9. PMID: 22753926; PMCID: PMC3444306.
  56. Yoong P, Pier GB. Immune-activating properties of Panton-Valentine leukocidin improve the outcome in a model of methicillin-resistant Staphylococcus aureus pneumonia. Infect Immun. 2012 Aug; 80(8):2894-904. PMID: 22665379; PMCID: PMC3434579.
  57. Bentancor LV, Camacho-Peiro A, Bozkurt-Guzel C, Pier GB, Maira-Litrán T. Identification of Ata, a multifunctional trimeric autotransporter of Acinetobacter baumannii. J Bacteriol. 2012 Aug; 194(15):3950-60. PMID: 22609912; PMCID: PMC3416510.
  58. Pozzi C, Waters EM, Rudkin JK, Schaeffer CR, Lohan AJ, Tong P, Loftus BJ, Pier GB, Fey PD, Massey RC, O'Gara JP. Methicillin resistance alters the biofilm phenotype and attenuates virulence in Staphylococcus aureus device-associated infections. PLoS Pathog. 2012; 8(4):e1002626. PMID: 22496652; PMCID: PMC3320603.
  59. Skurnik D, Davis MR, Benedetti D, Moravec KL, Cywes-Bentley C, Roux D, Traficante DC, Walsh RL, Maira-Litràn T, Cassidy SK, Hermos CR, Martin TR, Thakkallapalli EL, Vargas SO, McAdam AJ, Lieberman TD, Kishony R, Lipuma JJ, Pier GB, Goldberg JB, Priebe GP. Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection. J Infect Dis. 2012 Jun; 205(11):1709-18. PMID: 22448004.
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  60. Bentancor LV, O'Malley JM, Bozkurt-Guzel C, Pier GB, Maira-Litrán T. Poly-N-acetyl-ß-(1-6)-glucosamine is a target for protective immunity against Acinetobacter baumannii infections. Infect Immun. 2012 Feb; 80(2):651-6. PMID: 22104104; PMCID: PMC3264292.
  61. Lopez-Medina E, Neubauer MM, Pier GB, Koh AY. RNA isolation of Pseudomonas aeruginosa colonizing the murine gastrointestinal tract. J Vis Exp. 2011 Sep 28; (55). PMID: 21989513; PMCID: PMC3230207.
  62. Grachev AA, Gerbst AG, Gening ML, Titov DV, Yudina ON, Tsvetkov YE, Shashkov AS, Pier GB, Nifantiev NE. NMR and conformational studies of linear and cyclic oligo-(1?6)-ß-D-glucosamines. Carbohydr Res. 2011 Nov 08; 346(15):2499-510. PMID: 21945383; PMCID: PMC3201778.
  63. Zaidi T, Reidy T, D'Ortona S, Fichorova R, Pier G, Gadjeva M. CD74 deficiency ameliorates Pseudomonas aeruginosa-induced ocular infection. Sci Rep. 2011; 1:58. PMID: 22355577; PMCID: PMC3216545.
  64. Pier GB. Refers to: J.-P. Rasigade, N. Sicot, F. Laurent, G. Lina, F. Vandenesch, J. Etienne, A history of Panton-Valentine leukocidin (PVL)-associated infection protects against death in PVL-associated pneumonia, Vaccine 29 (25) (2011) 4185-4186. Vaccine. 2012 Mar 09; 30(12):2045-6. PMID: 21821077.
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  65. Cerca F, Andrade F, França Â, Andrade EB, Ribeiro A, Almeida AA, Cerca N, Pier G, Azeredo J, Vilanova M. Staphylococcus epidermidis biofilms with higher proportions of dormant bacteria induce a lower activation of murine macrophages. J Med Microbiol. 2011 Dec; 60(Pt 12):1717-24. PMID: 21799197.
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  66. Campodónico VL, Llosa NJ, Bentancor LV, Maira-Litran T, Pier GB. Efficacy of a conjugate vaccine containing polymannuronic acid and flagellin against experimental Pseudomonas aeruginosa lung infection in mice. Infect Immun. 2011 Aug; 79(8):3455-64. PMID: 21628521; PMCID: PMC3147594.
  67. Yudina ON, Gening ML, Tsvetkov YE, Grachev AA, Pier GB, Nifantiev NE. Synthesis of five nona-ß-(1?6)-d-glucosamines with various patterns of N-acetylation corresponding to the fragments of exopolysaccharide of Staphylococcus aureus. Carbohydr Res. 2011 May 15; 346(7):905-13. PMID: 21474120; PMCID: PMC3085928.
  68. Pier G, Prince A, Cantin A. Cystic fibrosis: an-ion transport issue? Nat Med. 2011 Feb; 17(2):166-7. PMID: 21297610; PMCID: PMC4704456.
  69. Kamei A, Coutinho-Sledge YS, Goldberg JB, Priebe GP, Pier GB. Mucosal vaccination with a multivalent, live-attenuated vaccine induces multifactorial immunity against Pseudomonas aeruginosa acute lung infection. Infect Immun. 2011 Mar; 79(3):1289-99. PMID: 21149583; PMCID: PMC3067523.
  70. Koh AY, Mikkelsen PJ, Smith RS, Coggshall KT, Kamei A, Givskov M, Lory S, Pier GB. Utility of in vivo transcription profiling for identifying Pseudomonas aeruginosa genes needed for gastrointestinal colonization and dissemination. PLoS One. 2010 Dec 10; 5(12):e15131. PMID: 21170272; PMCID: PMC3000825.
  71. Hermos CR, Yoong P, Pier GB. High levels of antibody to panton-valentine leukocidin are not associated with resistance to Staphylococcus aureus-associated skin and soft-tissue infection. Clin Infect Dis. 2010 Nov 15; 51(10):1138-46. PMID: 20946065.
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  72. Skurnik D, Merighi M, Grout M, Gadjeva M, Maira-Litran T, Ericsson M, Goldmann DA, Huang SS, Datta R, Lee JC, Pier GB. Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice. J Clin Invest. 2010 Sep; 120(9):3220-33. PMID: 20739753; PMCID: PMC2929724.
  73. Levy H, Cannon CL, Asher D, García C, Cleveland RH, Pier GB, Knowles MR, Colin AA. Lack of correlation between pulmonary disease and cystic fibrosis transmembrane conductance regulator dysfunction in cystic fibrosis: a case report. J Med Case Rep. 2010 Apr 26; 4:117. PMID: 20420703; PMCID: PMC2873450.
  74. Ulrich M, Worlitzsch D, Viglio S, Siegmann N, Iadarola P, Shute JK, Geiser M, Pier GB, Friedel G, Barr ML, Schuster A, Meyer KC, Ratjen F, Bjarnsholt T, Gulbins E, Döring G. Alveolar inflammation in cystic fibrosis. J Cyst Fibros. 2010 May; 9(3):217-27. PMID: 20347403; PMCID: PMC2883667.
  75. Gadjeva M, Nagashima J, Zaidi T, Mitchell RA, Pier GB. Inhibition of macrophage migration inhibitory factor ameliorates ocular Pseudomonas aeruginosa-induced keratitis. PLoS Pathog. 2010 Mar 26; 6(3):e1000826. PMID: 20361053; PMCID: PMC2845658.
  76. Skurnik D, Ruimy R, Ready D, Ruppe E, Bernède-Bauduin C, Djossou F, Guillemot D, Pier GB, Andremont A. Is exposure to mercury a driving force for the carriage of antibiotic resistance genes? J Med Microbiol. 2010 Jul; 59(Pt 7):804-7. PMID: 20339018.
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  77. Kallen R. Antibiotic prophylaxis and recurrent urinary tract infection in children. N Engl J Med. 2010 Feb 11; 362(6):555; author reply 556-7. PMID: 20147724.
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  78. Skurnik D, Pier GB, Andremont A. Antibiotic prophylaxis and recurrent urinary tract infection in children. N Engl J Med. 2010 Feb 11; 362(6):555-6; author reply 556-7. PMID: 20175297.
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  79. Yoong P, Pier GB. Antibody-mediated enhancement of community-acquired methicillin-resistant Staphylococcus aureus infection. Proc Natl Acad Sci U S A. 2010 Feb 02; 107(5):2241-6. PMID: 20133867; PMCID: PMC2836673.
  80. Kamei A, Koh AY, Gadjeva M, Priebe GP, Lory S, Pier GB. Analysis of acquisition of Pseudomonas aeruginosa gastrointestinal mucosal colonization and horizontal transmission in a murine model. J Infect Dis. 2010 Jan 01; 201(1):71-80. PMID: 19938976; PMCID: PMC2791183.
  81. Campodónico VL, Llosa NJ, Grout M, Döring G, Maira-Litrán T, Pier GB. Evaluation of flagella and flagellin of Pseudomonas aeruginosa as vaccines. Infect Immun. 2010 Feb; 78(2):746-55. PMID: 19995892; PMCID: PMC2812208.
  82. Gadjeva M, Paradis-Bleau C, Priebe GP, Fichorova R, Pier GB. Caveolin-1 modifies the immunity to Pseudomonas aeruginosa. J Immunol. 2010 Jan 01; 184(1):296-302. PMID: 19949109; PMCID: PMC2900931.
  83. Gening ML, Maira-Litrán T, Kropec A, Skurnik D, Grout M, Tsvetkov YE, Nifantiev NE, Pier GB. Synthetic {beta}-(1->6)-linked N-acetylated and nonacetylated oligoglucosamines used to produce conjugate vaccines for bacterial pathogens. Infect Immun. 2010 Feb; 78(2):764-72. PMID: 19948836; PMCID: PMC2812210.
  84. Zaidi TS, Zaidi T, Pier GB. Role of neutrophils, MyD88-mediated neutrophil recruitment, and complement in antibody-mediated defense against Pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci. 2010 Apr; 51(4):2085-93. PMID: 19892865; PMCID: PMC2868398.
  85. Koh AY, Priebe GP, Ray C, Van Rooijen N, Pier GB. Inescapable need for neutrophils as mediators of cellular innate immunity to acute Pseudomonas aeruginosa pneumonia. Infect Immun. 2009 Dec; 77(12):5300-10. PMID: 19805527; PMCID: PMC2786465.
  86. Choi AH, Slamti L, Avci FY, Pier GB, Maira-Litrán T. The pgaABCD locus of Acinetobacter baumannii encodes the production of poly-beta-1-6-N-acetylglucosamine, which is critical for biofilm formation. J Bacteriol. 2009 Oct; 191(19):5953-63. PMID: 19633088; PMCID: PMC2747904.
  87. Van Gennip M, Christensen LD, Alhede M, Phipps R, Jensen PØ, Christophersen L, Pamp SJ, Moser C, Mikkelsen PJ, Koh AY, Tolker-Nielsen T, Pier GB, Høiby N, Givskov M, Bjarnsholt T. Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes. APMIS. 2009 Jul; 117(7):537-46. PMID: 19594494; PMCID: PMC2997331.
  88. Levy H, Murphy A, Zou F, Gerard C, Klanderman B, Schuemann B, Lazarus R, García KC, Celedón JC, Drumm M, Dahmer M, Quasney M, Schneck K, Reske M, Knowles MR, Pier GB, Lange C, Weiss ST. IL1B polymorphisms modulate cystic fibrosis lung disease. Pediatr Pulmonol. 2009 Jun; 44(6):580-93. PMID: 19431193; PMCID: PMC3716579.
  89. Bajmoczi M, Gadjeva M, Alper SL, Pier GB, Golan DE. Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa. Am J Physiol Cell Physiol. 2009 Aug; 297(2):C263-77. PMID: 19386787; PMCID: PMC2724095.
  90. Feodorova VA, Pan'kina LN, Savostina EP, Kuznetsov OS, Konnov NP, Sayapina LV, Dentovskaya SV, Shaikhutdinova RZ, Ageev SA, Lindner B, Kondakova AN, Bystrova OV, Kocharova NA, Senchenkova SN, Holst O, Pier GB, Knirel YA, Anisimov AP, Motin VL. Pleiotropic effects of the lpxM mutation in Yersinia pestis resulting in modification of the biosynthesis of major immunoreactive antigens. Vaccine. 2009 Apr 06; 27(16):2240-50. PMID: 19428838; PMCID: PMC2999740.
  91. Pérez MM, Prenafeta A, Valle J, Penadés J, Rota C, Solano C, Marco J, Grilló MJ, Lasa I, Irache JM, Maira-Litran T, Jiménez-Barbero J, Costa L, Pier GB, de Andrés D, Amorena B. Protection from Staphylococcus aureus mastitis associated with poly-N-acetyl beta-1,6 glucosamine specific antibody production using biofilm-embedded bacteria. Vaccine. 2009 Apr 14; 27(17):2379-86. PMID: 19428854; PMCID: PMC3024585.
  92. Pier GB. On the greatly exaggerated reports of the death of infectious diseases. Clin Infect Dis. 2008 Oct 15; 47(8):1113-4. PMID: 18800937.
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  93. Komarova BS, Tsvetkov YE, Pier GB, Nifantiev NE. First synthesis of pentasaccharide glycoform I of the outer core region of the Pseudomonas aeruginosa lipopolysaccharide. J Org Chem. 2008 Nov 07; 73(21):8411-21. PMID: 18842026; PMCID: PMC2744294.
  94. Priebe GP, Walsh RL, Cederroth TA, Kamei A, Coutinho-Sledge YS, Goldberg JB, Pier GB. IL-17 is a critical component of vaccine-induced protection against lung infection by lipopolysaccharide-heterologous strains of Pseudomonas aeruginosa. J Immunol. 2008 Oct 01; 181(7):4965-75. PMID: 18802100; PMCID: PMC2597098.
  95. Zaidi T, Pier GB. Prophylactic and therapeutic efficacy of a fully human immunoglobulin G1 monoclonal antibody to Pseudomonas aeruginosa alginate in murine keratitis infection. Infect Immun. 2008 Oct; 76(10):4720-5. PMID: 18644881; PMCID: PMC2546830.
  96. Qiu D, Eisinger VM, Head NE, Pier GB, Yu HD. ClpXP proteases positively regulate alginate overexpression and mucoid conversion in Pseudomonas aeruginosa. Microbiology. 2008 Jul; 154(Pt 7):2119-30. PMID: 18599839; PMCID: PMC2995304.
  97. Levy H, Kalish LA, Cannon CL, García KC, Gerard C, Goldmann D, Pier GB, Weiss ST, Colin AA. Predictors of mucoid Pseudomonas colonization in cystic fibrosis patients. Pediatr Pulmonol. 2008 May; 43(5):463-71. PMID: 18361452; PMCID: PMC3693457.
  98. Pier GB. Dropping acid to help cystic fibrosis. Nat Med. 2008 Apr; 14(4):367-9. PMID: 18391932.
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  99. Zaidi T, Bajmoczi M, Zaidi T, Golan DE, Pier GB. Disruption of CFTR-dependent lipid rafts reduces bacterial levels and corneal disease in a murine model of Pseudomonas aeruginosa keratitis. Invest Ophthalmol Vis Sci. 2008 Mar; 49(3):1000-9. PMID: 18326723; PMCID: PMC2279184.
  100. Vergara-Irigaray M, Maira-Litrán T, Merino N, Pier GB, Penadés JR, Lasa I. Wall teichoic acids are dispensable for anchoring the PNAG exopolysaccharide to the Staphylococcus aureus cell surface. Microbiology. 2008 Mar; 154(Pt 3):865-77. PMID: 18310032; PMCID: PMC2292800.
  101. Campodónico VL, Gadjeva M, Paradis-Bleau C, Uluer A, Pier GB. Airway epithelial control of Pseudomonas aeruginosa infection in cystic fibrosis. Trends Mol Med. 2008 Mar; 14(3):120-33. PMID: 18262467; PMCID: PMC3697050.
  102. Koh AY, Köhler JR, Coggshall KT, Van Rooijen N, Pier GB. Mucosal damage and neutropenia are required for Candida albicans dissemination. PLoS Pathog. 2008 Feb 08; 4(2):e35. PMID: 18282097; PMCID: PMC2242836.
  103. Döring G, Pier GB. Vaccines and immunotherapy against Pseudomonas aeruginosa. Vaccine. 2008 Feb 20; 26(8):1011-24. PMID: 18242792.
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  104. Feodorova VA, Pan'kina LN, Savostina EP, Sayapina LV, Motin VL, Dentovskaya SV, Shaikhutdinova RZ, Ivanov SA, Lindner B, Kondakova AN, Bystrova OV, Kocharova NA, Senchenkova SN, Holst O, Pier GB, Knirel YA, Anisimov AP. A Yersinia pestis lpxM-mutant live vaccine induces enhanced immunity against bubonic plague in mice and guinea pigs. Vaccine. 2007 Nov 01; 25(44):7620-8. PMID: 17913308.
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  105. Kowalski MP, Dubouix-Bourandy A, Bajmoczi M, Golan DE, Zaidi T, Coutinho-Sledge YS, Gygi MP, Gygi SP, Wiemer EA, Pier GB. Host resistance to lung infection mediated by major vault protein in epithelial cells. Science. 2007 Jul 06; 317(5834):130-2. PMID: 17615361; PMCID: PMC3685177.
  106. Cerca N, Jefferson KK, Maira-Litrán T, Pier DB, Kelly-Quintos C, Goldmann DA, Azeredo J, Pier GB. Molecular basis for preferential protective efficacy of antibodies directed to the poorly acetylated form of staphylococcal poly-N-acetyl-beta-(1-6)-glucosamine. Infect Immun. 2007 Jul; 75(7):3406-13. PMID: 17470540; PMCID: PMC1932961.
  107. Pier GB. Pseudomonas aeruginosa lipopolysaccharide: a major virulence factor, initiator of inflammation and target for effective immunity. Int J Med Microbiol. 2007 Sep; 297(5):277-95. PMID: 17466590; PMCID: PMC1994162.
  108. Cerca N, Maira-Litrán T, Jefferson KK, Grout M, Goldmann DA, Pier GB. Protection against Escherichia coli infection by antibody to the Staphylococcus aureus poly-N-acetylglucosamine surface polysaccharide. Proc Natl Acad Sci U S A. 2007 May 01; 104(18):7528-33. PMID: 17446272; PMCID: PMC1863476.
  109. Anisimov AP, Shaikhutdinova RZ, Pan'kina LN, Feodorova VA, Savostina EP, Bystrova OV, Lindner B, Mokrievich AN, Bakhteeva IV, Titareva GM, Dentovskaya SV, Kocharova NA, Senchenkova SN, Holst O, Devdariani ZL, Popov YA, Pier GB, Knirel YA. Effect of deletion of the lpxM gene on virulence and vaccine potential of Yersinia pestis in mice. J Med Microbiol. 2007 Apr; 56(Pt 4):443-53. PMID: 17374882.
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  110. Pier GB. Is Pseudomonas aeruginosa exotoxin A a good carrier protein for conjugate vaccines? Hum Vaccin. 2007 Mar-Apr; 3(2):39-40; author reply 41. PMID: 17268204.
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  111. DiGiandomenico A, Rao J, Harcher K, Zaidi TS, Gardner J, Neely AN, Pier GB, Goldberg JB. Intranasal immunization with heterologously expressed polysaccharide protects against multiple Pseudomonas aeruginosa infections. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4624-9. PMID: 17360574; PMCID: PMC1838651.
  112. Levy H, Kalish LA, Huntington I, Weller N, Gerard C, Silverman EK, Celedón JC, Pier GB, Weiss ST. Inflammatory markers of lung disease in adult patients with cystic fibrosis. Pediatr Pulmonol. 2007 Mar; 42(3):256-62. PMID: 17245735; PMCID: PMC4469989.
  113. Reiniger N, Lee MM, Coleman FT, Ray C, Golan DE, Pier GB. Resistance to Pseudomonas aeruginosa chronic lung infection requires cystic fibrosis transmembrane conductance regulator-modulated interleukin-1 (IL-1) release and signaling through the IL-1 receptor. Infect Immun. 2007 Apr; 75(4):1598-608. PMID: 17283089; PMCID: PMC1865697.
  114. Knirel YA, Dentovskaya SV, Bystrova OV, Kocharova NA, Senchenkova SN, Shaikhutdinova RZ, Titareva GM, Bakhteeva IV, Lindner B, Pier GB, Anisimov AP. Relationship of the lipopolysaccharide structure of Yersinia pestis to resistance to antimicrobial factors. Adv Exp Med Biol. 2007; 603:88-96. PMID: 17966406.
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  115. Pier GB. Airway epithelial (nasal) cell monolayers used to study Pseudomonas aeruginosa invasion are hyperpolarized and not representative of the human airway epithelium. Infect Immun. 2006 Dec; 74(12):7043; author reply 7043-4. PMID: 17116966; PMCID: PMC1698054.
  116. Gening ML, Tsvetkov YE, Pier GB, Nifantiev NE. Synthesis of beta-(1-->6)-linked glucosamine oligosaccharides corresponding to fragments of the bacterial surface polysaccharide poly-N-acetylglucosamine. Carbohydr Res. 2007 Feb 26; 342(3-4):567-75. PMID: 16952342.
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  117. Cerca N, Jefferson KK, Oliveira R, Pier GB, Azeredo J. Comparative antibody-mediated phagocytosis of Staphylococcus epidermidis cells grown in a biofilm or in the planktonic state. Infect Immun. 2006 Aug; 74(8):4849-55. PMID: 16861673; PMCID: PMC1539625.
  118. Gening ML, Tsvetkov IuE, Pier GB, Nifant'ev NE. [The study of the reaction of terminated oligomerization in the synthesis of oligo-(beta1-6)-glucosamines]. Bioorg Khim. 2006 Jul-Aug; 32(4):432-43. PMID: 16909868.
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  119. Kelly-Quintos C, Cavacini LA, Posner MR, Goldmann D, Pier GB. Characterization of the opsonic and protective activity against Staphylococcus aureus of fully human monoclonal antibodies specific for the bacterial surface polysaccharide poly-N-acetylglucosamine. Infect Immun. 2006 May; 74(5):2742-50. PMID: 16622211; PMCID: PMC1459728.
  120. Zaidi TS, Priebe GP, Pier GB. A live-attenuated Pseudomonas aeruginosa vaccine elicits outer membrane protein-specific active and passive protection against corneal infection. Infect Immun. 2006 Feb; 74(2):975-83. PMID: 16428743; PMCID: PMC1360306.
  121. Bystrova OV, Knirel YA, Lindner B, Kocharova NA, Kondakova AN, Zähringer U, Pier GB. Structures of the core oligosaccharide and O-units in the R- and SR-type lipopolysaccharides of reference strains of Pseudomonas aeruginosa O-serogroups. FEMS Immunol Med Microbiol. 2006 Feb; 46(1):85-99. PMID: 16420601.
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  122. Knirel YA, Bystrova OV, Kocharova NA, Zähringer U, Pier GB. Conserved and variable structural features in the lipopolysaccharide of Pseudomonas aeruginosa. J Endotoxin Res. 2006; 12(6):324-36. PMID: 17254386.
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  123. Cerca N, Martins S, Sillankorva S, Jefferson KK, Pier GB, Oliveira R, Azeredo J. Effects of growth in the presence of subinhibitory concentrations of dicloxacillin on Staphylococcus epidermidis and Staphylococcus haemolyticus biofilms. Appl Environ Microbiol. 2005 Dec; 71(12):8677-82. PMID: 16332862; PMCID: PMC1317332.
  124. Kelly-Quintos C, Kropec A, Briggs S, Ordonez CL, Goldmann DA, Pier GB. The role of epitope specificity in the human opsonic antibody response to the staphylococcal surface polysaccharide poly N-acetyl glucosamine. J Infect Dis. 2005 Dec 01; 192(11):2012-9. PMID: 16267775.
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  125. Anisimov AP, Dentovskaya SV, Titareva GM, Bakhteeva IV, Shaikhutdinova RZ, Balakhonov SV, Lindner B, Kocharova NA, Senchenkova SN, Holst O, Pier GB, Knirel YA. Intraspecies and temperature-dependent variations in susceptibility of Yersinia pestis to the bactericidal action of serum and to polymyxin B. Infect Immun. 2005 Nov; 73(11):7324-31. PMID: 16239530; PMCID: PMC1273868.
  126. Maira-Litrán T, Kropec A, Goldmann DA, Pier GB. Comparative opsonic and protective activities of Staphylococcus aureus conjugate vaccines containing native or deacetylated Staphylococcal Poly-N-acetyl-beta-(1-6)-glucosamine. Infect Immun. 2005 Oct; 73(10):6752-62. PMID: 16177353; PMCID: PMC1230901.
  127. Kropec A, Maira-Litran T, Jefferson KK, Grout M, Cramton SE, Götz F, Goldmann DA, Pier GB. Poly-N-acetylglucosamine production in Staphylococcus aureus is essential for virulence in murine models of systemic infection. Infect Immun. 2005 Oct; 73(10):6868-76. PMID: 16177366; PMCID: PMC1230935.
  128. Pier G. Application of vaccine technology to prevention of Pseudomonas aeruginosa infections. Expert Rev Vaccines. 2005 Oct; 4(5):645-56. PMID: 16221066.
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  129. Reiniger N, Ichikawa JK, Pier GB. Influence of cystic fibrosis transmembrane conductance regulator on gene expression in response to Pseudomonas aeruginosa infection of human bronchial epithelial cells. Infect Immun. 2005 Oct; 73(10):6822-30. PMID: 16177360; PMCID: PMC1230967.
  130. Knirel YA, Lindner B, Vinogradov E, Shaikhutdinova RZ, Senchenkova SN, Kocharova NA, Holst O, Pier GB, Anisimov AP. Cold temperature-induced modifications to the composition and structure of the lipopolysaccharide of Yersinia pestis. Carbohydr Res. 2005 Jul 04; 340(9):1625-30. PMID: 15907814.
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  131. Bragonzi A, Worlitzsch D, Pier GB, Timpert P, Ulrich M, Hentzer M, Andersen JB, Givskov M, Conese M, Doring G. Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse model. J Infect Dis. 2005 Aug 01; 192(3):410-9. PMID: 15995954; PMCID: PMC1317300.
  132. Cerca N, Martins S, Cerca F, Jefferson KK, Pier GB, Oliveira R, Azeredo J. Comparative assessment of antibiotic susceptibility of coagulase-negative staphylococci in biofilm versus planktonic culture as assessed by bacterial enumeration or rapid XTT colorimetry. J Antimicrob Chemother. 2005 Aug; 56(2):331-6. PMID: 15980094; PMCID: PMC1317301.
  133. Jefferson KK, Goldmann DA, Pier GB. Use of confocal microscopy to analyze the rate of vancomycin penetration through Staphylococcus aureus biofilms. Antimicrob Agents Chemother. 2005 Jun; 49(6):2467-73. PMID: 15917548; PMCID: PMC1140491.
  134. Lai Z, Kimmel R, Petersen S, Thomas S, Pier G, Bezabeh B, Luo R, Schreiber JR. Multi-valent human monoclonal antibody preparation against Pseudomonas aeruginosa derived from transgenic mice containing human immunoglobulin loci is protective against fatal pseudomonas sepsis caused by multiple serotypes. Vaccine. 2005 May 09; 23(25):3264-71. PMID: 15837231.
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  135. Koh AY, Priebe GP, Pier GB. Virulence of Pseudomonas aeruginosa in a murine model of gastrointestinal colonization and dissemination in neutropenia. Infect Immun. 2005 Apr; 73(4):2262-72. PMID: 15784570; PMCID: PMC1087461.
  136. Cerca N, Martins S, Pier GB, Oliveira R, Azeredo J. The relationship between inhibition of bacterial adhesion to a solid surface by sub-MICs of antibiotics and subsequent development of a biofilm. Res Microbiol. 2005 Jun-Jul; 156(5-6):650-5. PMID: 15950124; PMCID: PMC1351067.
  137. Cerca N, Pier GB, Vilanova M, Oliveira R, Azeredo J. Quantitative analysis of adhesion and biofilm formation on hydrophilic and hydrophobic surfaces of clinical isolates of Staphylococcus epidermidis. Res Microbiol. 2005 May; 156(4):506-14. PMID: 15862449; PMCID: PMC1356821.
  138. Knirel YA, Lindner B, Vinogradov EV, Kocharova NA, Senchenkova SN, Shaikhutdinova RZ, Dentovskaya SV, Fursova NK, Bakhteeva IV, Titareva GM, Balakhonov SV, Holst O, Gremyakova TA, Pier GB, Anisimov AP. Temperature-dependent variations and intraspecies diversity of the structure of the lipopolysaccharide of Yersinia pestis. Biochemistry. 2005 Feb 08; 44(5):1731-43. PMID: 15683257.
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  139. Pier GB, Boyer D, Preston M, Coleman FT, Llosa N, Mueschenborn-Koglin S, Theilacker C, Goldenberg H, Uchin J, Priebe GP, Grout M, Posner M, Cavacini L. Human monoclonal antibodies to Pseudomonas aeruginosa alginate that protect against infection by both mucoid and nonmucoid strains. J Immunol. 2004 Nov 01; 173(9):5671-8. PMID: 15494518.
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  140. Cerca N, Pier GB, Oliveira R, Azeredo J. Comparative evaluation of coagulase-negative staphylococci (CoNS) adherence to acrylic by a static method and a parallel-plate flow dynamic method. Res Microbiol. 2004 Nov; 155(9):755-60. PMID: 15501653.
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  141. Zaidi T, Mowrey-McKee M, Pier GB. Hypoxia increases corneal cell expression of CFTR leading to increased Pseudomonas aeruginosa binding, internalization, and initiation of inflammation. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):4066-74. PMID: 15505057; PMCID: PMC1317302.
  142. Priebe GP, Dean CR, Zaidi T, Meluleni GJ, Coleman FT, Coutinho YS, Noto MJ, Urban TA, Pier GB, Goldberg JB. The galU Gene of Pseudomonas aeruginosa is required for corneal infection and efficient systemic spread following pneumonia but not for infection confined to the lung. Infect Immun. 2004 Jul; 72(7):4224-32. PMID: 15213167; PMCID: PMC427465.
  143. Jefferson KK, Pier DB, Goldmann DA, Pier GB. The teicoplanin-associated locus regulator (TcaR) and the intercellular adhesin locus regulator (IcaR) are transcriptional inhibitors of the ica locus in Staphylococcus aureus. J Bacteriol. 2004 Apr; 186(8):2449-56. PMID: 15060048; PMCID: PMC412131.
  144. Anisimov AP, Lindler LE, Pier GB. Intraspecific diversity of Yersinia pestis. Clin Microbiol Rev. 2004 Apr; 17(2):434-64. PMID: 15084509; PMCID: PMC387406.
  145. Maira-Litran T, Kropec A, Goldmann D, Pier GB. Biologic properties and vaccine potential of the staphylococcal poly-N-acetyl glucosamine surface polysaccharide. Vaccine. 2004 Feb 17; 22(7):872-9. PMID: 15040940.
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  146. Walker RI, Blanchard T, Braun JM, Cebra JJ, Cross AS, Fattom A, Giannasca PJ, Holder IA, Huebner J, Matthews R, Pier GB, Romani L, von Specht BU, Trautmann M. Meeting summary: possibilities for active and passive vaccination against opportunistic infections. Vaccine. 2004 Feb 17; 22(7):801-4. PMID: 15040930.
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  147. Bystrova OV, Lindner B, Moll H, Kocharova NA, Knirel YA, Zahringer U, Pier GB. Full structure of the lipopolysaccharide of Pseudomonas aeruginosa immunotype 5. Biochemistry (Mosc). 2004 Feb; 69(2):170-5. PMID: 15000683; PMCID: PMC1317305.
  148. Krueger WA, Krueger-Rameck S, Koch S, Carey V, Pier GB, Huebner J. Assessment of the role of antibiotics and enterococcal virulence factors in a mouse model of extraintestinal translocation. Crit Care Med. 2004 Feb; 32(2):467-71. PMID: 14758165.
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  149. Kowalski MP, Pier GB. Localization of cystic fibrosis transmembrane conductance regulator to lipid rafts of epithelial cells is required for Pseudomonas aeruginosa-induced cellular activation. J Immunol. 2004 Jan 01; 172(1):418-25. PMID: 14688350.
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  150. Cerca N, Pier GB, Vilanova M, Oliveira R, Azeredo J. Influence of batch or fed-batch growth on Staphylococcus epidermidis biofilm formation. Lett Appl Microbiol. 2004; 39(5):420-4. PMID: 15482432; PMCID: PMC1317303.
  151. Cabrol S, Olliver A, Pier GB, Andremont A, Ruimy R. Transcription of quorum-sensing system genes in clinical and environmental isolates of Pseudomonas aeruginosa. J Bacteriol. 2003 Dec; 185(24):7222-30. PMID: 14645283; PMCID: PMC296264.
  152. Pier GB. Promises and pitfalls of Pseudomonas aeruginosa lipopolysaccharide as a vaccine antigen. Carbohydr Res. 2003 Nov 14; 338(23):2549-56. PMID: 14670716.
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  153. Bystrova OV, Lindner B, Moll H, Kocharova NA, Knirel YA, Zähringer U, Pier GB. Structure of the lipopolysaccharide of Pseudomonas aeruginosa O-12 with a randomly O-acetylated core region. Carbohydr Res. 2003 Sep 01; 338(18):1895-905. PMID: 12932374.
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  154. Ullrich S, Berchtold S, Boehmer C, Fillon S, Jendrossek V, Palmada M, Schroeder TH, Pier GB, Lang F. Pseudomonas aeruginosa activates Cl- channels in host epithelial cells. Pflugers Arch. 2003 Oct; 447(1):23-8. PMID: 12920599.
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  155. Bystrova OV, Lindner B, Moll H, Kocharova NA, Knirel YA, Zähringer U, Pier GB. Structure of the biological repeating unit of the O-antigen of Pseudomonas aeruginosa immunotype 4 containing both 2-acetamido-2,6-dideoxy-D-glucose and 2-acetamido-2,6-dideoxy-D-galactose. Carbohydr Res. 2003 Aug 12; 338(17):1801-6. PMID: 12892948.
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  156. Bystrova OV, Shashkov AS, Kocharova NA, Knirel YA, Zähringer U, Pier GB. Elucidation of the structure of the lipopolysaccharide core and the linkage between the core and the O-antigen in Pseudomonas aeruginosa immunotype 5 using strong alkaline degradation of the lipopolysaccharide. Biochemistry (Mosc). 2003 Aug; 68(8):918-25. PMID: 12948393.
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  157. Cannon CL, Kowalski MP, Stopak KS, Pier GB. Pseudomonas aeruginosa-induced apoptosis is defective in respiratory epithelial cells expressing mutant cystic fibrosis transmembrane conductance regulator. Am J Respir Cell Mol Biol. 2003 Aug; 29(2):188-97. PMID: 12878584.
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  158. Theilacker C, Coleman FT, Mueschenborn S, Llosa N, Grout M, Pier GB. Construction and characterization of a Pseudomonas aeruginosa mucoid exopolysaccharide-alginate conjugate vaccine. Infect Immun. 2003 Jul; 71(7):3875-84. PMID: 12819072; PMCID: PMC162014.
  159. Jefferson KK, Cramton SE, Götz F, Pier GB. Identification of a 5-nucleotide sequence that controls expression of the ica locus in Staphylococcus aureus and characterization of the DNA-binding properties of IcaR. Mol Microbiol. 2003 May; 48(4):889-99. PMID: 12753184.
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  160. Joyce JG, Abeygunawardana C, Xu Q, Cook JC, Hepler R, Przysiecki CT, Grimm KM, Roper K, Ip CC, Cope L, Montgomery D, Chang M, Campie S, Brown M, McNeely TB, Zorman J, Maira-Litrán T, Pier GB, Keller PM, Jansen KU, Mark GE. Isolation, structural characterization, and immunological evaluation of a high-molecular-weight exopolysaccharide from Staphylococcus aureus. Carbohydr Res. 2003 Apr 22; 338(9):903-22. PMID: 12681914.
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  161. Priebe GP, Meluleni GJ, Coleman FT, Goldberg JB, Pier GB. Protection against fatal Pseudomonas aeruginosa pneumonia in mice after nasal immunization with a live, attenuated aroA deletion mutant. Infect Immun. 2003 Mar; 71(3):1453-61. PMID: 12595463; PMCID: PMC148856.
  162. Coleman FT, Mueschenborn S, Meluleni G, Ray C, Carey VJ, Vargas SO, Cannon CL, Ausubel FM, Pier GB. Hypersusceptibility of cystic fibrosis mice to chronic Pseudomonas aeruginosa oropharyngeal colonization and lung infection. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1949-54. PMID: 12578988; PMCID: PMC149939.
  163. Lyczak JB, Pier GB. Salmonella enterica serovar typhi modulates cell surface expression of its receptor, the cystic fibrosis transmembrane conductance regulator, on the intestinal epithelium. Infect Immun. 2002 Nov; 70(11):6416-23. PMID: 12379722; PMCID: PMC130400.
  164. Maira-Litrán T, Kropec A, Abeygunawardana C, Joyce J, Mark G, Goldmann DA, Pier GB. Immunochemical properties of the staphylococcal poly-N-acetylglucosamine surface polysaccharide. Infect Immun. 2002 Aug; 70(8):4433-40. PMID: 12117954; PMCID: PMC128161.
  165. Schroeder TH, Lee MM, Yacono PW, Cannon CL, Gerçeker AA, Golan DE, Pier GB. CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6907-12. PMID: 11997458; PMCID: PMC124502.
  166. Lyczak JB, Cannon CL, Pier GB. Lung infections associated with cystic fibrosis. Clin Microbiol Rev. 2002 Apr; 15(2):194-222. PMID: 11932230; PMCID: PMC118069.
  167. Bystrova OV, Shashkov AS, Kocharova NA, Knirel YA, Lindner B, Zähringer U, Pier GB. Structural studies on the core and the O-polysaccharide repeating unit of Pseudomonas aeruginosa immunotype 1 lipopolysaccharide. Eur J Biochem. 2002 Apr; 269(8):2194-203. PMID: 11985598.
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  168. Priebe GP, Brinig MM, Hatano K, Grout M, Coleman FT, Pier GB, Goldberg JB. Construction and characterization of a live, attenuated aroA deletion mutant of Pseudomonas aeruginosa as a candidate intranasal vaccine. Infect Immun. 2002 Mar; 70(3):1507-17. PMID: 11854239; PMCID: PMC127764.
  169. Pier GB. CFTR mutations and host susceptibility to Pseudomonas aeruginosa lung infection. Curr Opin Microbiol. 2002 Feb; 5(1):81-6. PMID: 11834374.
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  170. Lyczak JB, Zaidi TS, Grout M, Bittner M, Contreras I, Pier GB. Epithelial cell contact-induced alterations in Salmonella enterica serovar Typhi lipopolysaccharide are critical for bacterial internalization. Cell Microbiol. 2001 Nov; 3(11):763-72. PMID: 11696036.
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  171. Knirel YA, Bystrova OV, Shashkov AS, Lindner B, Kocharova NA, Senchenkova SN, Moll H, Zähringer U, Hatano K, Pier GB. Structural analysis of the lipopolysaccharide core of a rough, cystic fibrosis isolate of Pseudomonas aeruginosa. Eur J Biochem. 2001 Sep; 268(17):4708-19. PMID: 11532007.
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  172. Schroeder TH, Reiniger N, Meluleni G, Grout M, Coleman FT, Pier GB. Transgenic cystic fibrosis mice exhibit reduced early clearance of Pseudomonas aeruginosa from the respiratory tract. J Immunol. 2001 Jun 15; 166(12):7410-8. PMID: 11390493.
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  173. Park PW, Pier GB, Hinkes MT, Bernfield M. Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 2001 May 03; 411(6833):98-102. PMID: 11333985.
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  174. Hemachandra S, Kamboj K, Copfer J, Pier G, Green LL, Schreiber JR. Human monoclonal antibodies against Pseudomonas aeruginosa lipopolysaccharide derived from transgenic mice containing megabase human immunoglobulin loci are opsonic and protective against fatal pseudomonas sepsis. Infect Immun. 2001 Apr; 69(4):2223-9. PMID: 11254577; PMCID: PMC98149.
  175. Pier GB, Coleman F, Grout M, Franklin M, Ohman DE. Role of alginate O acetylation in resistance of mucoid Pseudomonas aeruginosa to opsonic phagocytosis. Infect Immun. 2001 Mar; 69(3):1895-901. PMID: 11179370; PMCID: PMC98099.
  176. Schroeder TH, Zaidi T, Pier GB. Lack of adherence of clinical isolates of Pseudomonas aeruginosa to asialo-GM(1) on epithelial cells. Infect Immun. 2001 Feb; 69(2):719-29. PMID: 11159960; PMCID: PMC97944.
  177. Goldberg JB, Pier GB. The role of the CFTR in susceptibility to Pseudomonas aeruginosa infections in cystic fibrosis. Trends Microbiol. 2000 Nov; 8(11):514-20. PMID: 11121762.
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  178. Mckenney D, Pouliot K, Wang Y, Murthy V, Ulrich M, Döring G, Lee JC, Goldmann DA, Pier GB. Vaccine potential of poly-1-6 beta-D-N-succinylglucosamine, an immunoprotective surface polysaccharide of Staphylococcus aureus and Staphylococcus epidermidis. J Biotechnol. 2000 Sep 29; 83(1-2):37-44. PMID: 11000458.
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  179. Pier GB. Role of the cystic fibrosis transmembrane conductance regulator in innate immunity to Pseudomonas aeruginosa infections. Proc Natl Acad Sci U S A. 2000 Aug 01; 97(16):8822-8. PMID: 10922041; PMCID: PMC34018.
  180. Huebner J, Quaas A, Krueger WA, Goldmann DA, Pier GB. Prophylactic and therapeutic efficacy of antibodies to a capsular polysaccharide shared among vancomycin-sensitive and -resistant enterococci. Infect Immun. 2000 Aug; 68(8):4631-6. PMID: 10899866; PMCID: PMC98395.
  181. Lyczak JB, Cannon CL, Pier GB. Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist. Microbes Infect. 2000 Jul; 2(9):1051-60. PMID: 10967285.
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  182. Allewelt M, Coleman FT, Grout M, Priebe GP, Pier GB. Acquisition of expression of the Pseudomonas aeruginosa ExoU cytotoxin leads to increased bacterial virulence in a murine model of acute pneumonia and systemic spread. Infect Immun. 2000 Jul; 68(7):3998-4004. PMID: 10858214; PMCID: PMC101680.
  183. Pier GB. Peptides, Pseudomonas aeruginosa, polysaccharides and lipopolysaccharides--players in the predicament of cystic fibrosis patients. Trends Microbiol. 2000 Jun; 8(6):247-50; discussion 250-1. PMID: 10838574.
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  184. Park PW, Pier GB, Preston MJ, Goldberger O, Fitzgerald ML, Bernfield M. Syndecan-1 shedding is enhanced by LasA, a secreted virulence factor of Pseudomonas aeruginosa. J Biol Chem. 2000 Feb 04; 275(5):3057-64. PMID: 10652286.
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  185. Gerçeker AA, Zaidi T, Marks P, Golan DE, Pier GB. Impact of heterogeneity within cultured cells on bacterial invasion: analysis of Pseudomonas aeruginosa and Salmonella enterica serovar typhi entry into MDCK cells by using a green fluorescent protein-labelled cystic fibrosis transmembrane conductance regulator receptor. Infect Immun. 2000 Feb; 68(2):861-70. PMID: 10639456; PMCID: PMC97215.
  186. Parad RB, Gerard CJ, Zurakowski D, Nichols DP, Pier GB. Pulmonary outcome in cystic fibrosis is influenced primarily by mucoid Pseudomonas aeruginosa infection and immune status and only modestly by genotype. Infect Immun. 1999 Sep; 67(9):4744-50. PMID: 10456926; PMCID: PMC96804.
  187. Dean CR, Franklund CV, Retief JD, Coyne MJ, Hatano K, Evans DJ, Pier GB, Goldberg JB. Characterization of the serogroup O11 O-antigen locus of Pseudomonas aeruginosa PA103. J Bacteriol. 1999 Jul; 181(14):4275-84. PMID: 10400585; PMCID: PMC93929.
  188. McKenney D, Pouliot KL, Wang Y, Murthy V, Ulrich M, Döring G, Lee JC, Goldmann DA, Pier GB. Broadly protective vaccine for Staphylococcus aureus based on an in vivo-expressed antigen. Science. 1999 May 28; 284(5419):1523-7. PMID: 10348739.
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  189. Wang Y, Huebner J, Tzianabos AO, Martirosian G, Kasper DL, Pier GB. Structure of an antigenic teichoic acid shared by clinical isolates of Enterococcus faecalis and vancomycin-resistant Enterococcus faecium. Carbohydr Res. 1999 Mar 31; 316(1-4):155-60. PMID: 10420594.
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  190. Huebner J, Wang Y, Krueger WA, Madoff LC, Martirosian G, Boisot S, Goldmann DA, Kasper DL, Tzianabos AO, Pier GB. Isolation and chemical characterization of a capsular polysaccharide antigen shared by clinical isolates of Enterococcus faecalis and vancomycin-resistant Enterococcus faecium. Infect Immun. 1999 Mar; 67(3):1213-9. PMID: 10024563; PMCID: PMC96449.
  191. Zaidi TS, Lyczak J, Preston M, Pier GB. Cystic fibrosis transmembrane conductance regulator-mediated corneal epithelial cell ingestion of Pseudomonas aeruginosa is a key component in the pathogenesis of experimental murine keratitis. Infect Immun. 1999 Mar; 67(3):1481-92. PMID: 10024598; PMCID: PMC96484.
  192. McKenney D, Hübner J, Muller E, Wang Y, Goldmann DA, Pier GB. The ica locus of Staphylococcus epidermidis encodes production of the capsular polysaccharide/adhesin. Infect Immun. 1998 Oct; 66(10):4711-20. PMID: 9746568; PMCID: PMC108579.
  193. Preston MJ, Gerçeker AA, Reff ME, Pier GB. Production and characterization of a set of mouse-human chimeric immunoglobulin G (IgG) subclass and IgA monoclonal antibodies with identical variable regions specific for Pseudomonas aeruginosa serogroup O6 lipopolysaccharide. Infect Immun. 1998 Sep; 66(9):4137-42. PMID: 9712759; PMCID: PMC108497.
  194. Hatano K, Pier GB. Complex serology and immune response of mice to variant high-molecular-weight O polysaccharides isolated from Pseudomonas aeruginosa serogroup O2 strains. Infect Immun. 1998 Aug; 66(8):3719-26. PMID: 9673254; PMCID: PMC108407.
  195. Pier GB, Grout M, Zaidi T, Meluleni G, Mueschenborn SS, Banting G, Ratcliff R, Evans MJ, Colledge WH. Salmonella typhi uses CFTR to enter intestinal epithelial cells. Nature. 1998 May 07; 393(6680):79-82. PMID: 9590693.
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  196. Pier GB, Grout M, Zaidi TS. Cystic fibrosis transmembrane conductance regulator is an epithelial cell receptor for clearance of Pseudomonas aeruginosa from the lung. Proc Natl Acad Sci U S A. 1997 Oct 28; 94(22):12088-93. PMID: 9342367; PMCID: PMC23711.
  197. Preston MJ, Seed PC, Toder DS, Iglewski BH, Ohman DE, Gustin JK, Goldberg JB, Pier GB. Contribution of proteases and LasR to the virulence of Pseudomonas aeruginosa during corneal infections. Infect Immun. 1997 Aug; 65(8):3086-90. PMID: 9234758; PMCID: PMC175435.
  198. Preston MJ, Gerçeker AA, Koles NL, Pollack M, Pier GB. Prophylactic and therapeutic efficacy of immunoglobulin G antibodies to Pseudomonas aeruginosa lipopolysaccharide against murine experimental corneal infection. Invest Ophthalmol Vis Sci. 1997 Jun; 38(7):1418-25. PMID: 9191605.
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  199. Zaidi TS, Preston MJ, Pier GB. Inhibition of bacterial adherence to host tissue does not markedly affect disease in the murine model of Pseudomonas aeruginosa corneal infection. Infect Immun. 1997 Apr; 65(4):1370-6. PMID: 9119476; PMCID: PMC175142.
  200. Pier GB. Rationale for development of immunotherapies that target mucoid Pseudomonas aeruginosa infection in cystic fibrosis patients. Behring Inst Mitt. 1997 Feb; (98):350-60. PMID: 9382760.
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  201. Pier GB, Grout M, Zaidi TS, Goldberg JB. How mutant CFTR may contribute to Pseudomonas aeruginosa infection in cystic fibrosis. Am J Respir Crit Care Med. 1996 Oct; 154(4 Pt 2):S175-82. PMID: 8876538.
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  202. Fleiszig SM, Evans DJ, Mowrey-McKee MF, Payor R, Zaidi TS, Vallas V, Muller E, Pier GB. Factors affecting Staphylococcus epidermidis adhesion to contact lenses. Optom Vis Sci. 1996 Sep; 73(9):590-4. PMID: 8887402.
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  203. Fleiszig SM, Zaidi TS, Preston MJ, Grout M, Evans DJ, Pier GB. Relationship between cytotoxicity and corneal epithelial cell invasion by clinical isolates of Pseudomonas aeruginosa. Infect Immun. 1996 Jun; 64(6):2288-94. PMID: 8675339; PMCID: PMC174068.
  204. Zaidi TS, Fleiszig SM, Preston MJ, Goldberg JB, Pier GB. Lipopolysaccharide outer core is a ligand for corneal cell binding and ingestion of Pseudomonas aeruginosa. Invest Ophthalmol Vis Sci. 1996 May; 37(6):976-86. PMID: 8631641.
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  205. Pier GB. Analysis of naturally occurring antibodies to mucoid Pseudomonas aeruginosa in cystic fibrosis patients. J Infect Dis. 1996 Feb; 173(2):513-5. PMID: 8568328.
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  206. Pier GB, Grout M, Zaidi TS, Olsen JC, Johnson LG, Yankaskas JR, Goldberg JB. Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections. Science. 1996 Jan 05; 271(5245):64-7. PMID: 8539601; PMCID: PMC3677515.
  207. Pier GB, Goldberg JB. Pseudomonas aeruginosa A-band and B-band lipopolysaccharides. Infect Immun. 1995 Dec; 63(12):4964-5. PMID: 7591168; PMCID: PMC173717.
  208. Shiro H, Meluleni G, Groll A, Muller E, Tosteson TD, Goldmann DA, Pier GB. The pathogenic role of Staphylococcus epidermidis capsular polysaccharide/adhesin in a low-inoculum rabbit model of prosthetic valve endocarditis. Circulation. 1995 Nov 01; 92(9):2715-22. PMID: 7586377.
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  209. Pollack M, Koles NL, Preston MJ, Brown BJ, Pier GB. Functional properties of isotype-switched immunoglobulin M (IgM) and IgG monoclonal antibodies to Pseudomonas aeruginosa lipopolysaccharide. Infect Immun. 1995 Nov; 63(11):4481-8. PMID: 7591089; PMCID: PMC173638.
  210. Fleiszig SM, Zaidi TS, Pier GB. Pseudomonas aeruginosa invasion of and multiplication within corneal epithelial cells in vitro. Infect Immun. 1995 Oct; 63(10):4072-7. PMID: 7558321; PMCID: PMC173572.
  211. Preston MJ, Fleiszig SM, Zaidi TS, Goldberg JB, Shortridge VD, Vasil ML, Pier GB. Rapid and sensitive method for evaluating Pseudomonas aeruginosa virulence factors during corneal infections in mice. Infect Immun. 1995 Sep; 63(9):3497-501. PMID: 7642283; PMCID: PMC173483.
  212. Meluleni GJ, Grout M, Evans DJ, Pier GB. Mucoid Pseudomonas aeruginosa growing in a biofilm in vitro are killed by opsonic antibodies to the mucoid exopolysaccharide capsule but not by antibodies produced during chronic lung infection in cystic fibrosis patients. J Immunol. 1995 Aug 15; 155(4):2029-38. PMID: 7636254.
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  213. Pier GB, Meluleni G, Goldberg JB. Clearance of Pseudomonas aeruginosa from the murine gastrointestinal tract is effectively mediated by O-antigen-specific circulating antibodies. Infect Immun. 1995 Aug; 63(8):2818-25. PMID: 7542632; PMCID: PMC173382.
  214. Shiro H, Muller E, Takeda S, Tosteson TD, Goldmann DA, Pier GB. Potentiation of Staphylococcus epidermidis catheter-related bacteremia by lipid infusions. J Infect Dis. 1995 Jan; 171(1):220-4. PMID: 7798668.
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  215. Hatano K, Goldberg JB, Pier GB. Biologic activities of antibodies to the neutral-polysaccharide component of the Pseudomonas aeruginosa lipopolysaccharide are blocked by O side chains and mucoid exopolysaccharide (alginate). Infect Immun. 1995 Jan; 63(1):21-6. PMID: 7528730; PMCID: PMC172952.
  216. Pier GB, DesJardin D, Grout M, Garner C, Bennett SE, Pekoe G, Fuller SA, Thornton MO, Harkonen WS, Miller HC. Human immune response to Pseudomonas aeruginosa mucoid exopolysaccharide (alginate) vaccine. Infect Immun. 1994 Sep; 62(9):3972-9. PMID: 8063415; PMCID: PMC303055.
  217. Hatano K, Boisot S, DesJardins D, Wright DC, Brisker J, Pier GB. Immunogenic and antigenic properties of a heptavalent high-molecular-weight O-polysaccharide vaccine derived from Pseudomonas aeruginosa. Infect Immun. 1994 Sep; 62(9):3608-16. PMID: 7520416; PMCID: PMC303009.
  218. Fleiszig SM, Zaidi TS, Fletcher EL, Preston MJ, Pier GB. Pseudomonas aeruginosa invades corneal epithelial cells during experimental infection. Infect Immun. 1994 Aug; 62(8):3485-93. PMID: 8039920; PMCID: PMC302982.
  219. Evans DJ, Pier GB, Coyne MJ, Goldberg JB. The rfb locus from Pseudomonas aeruginosa strain PA103 promotes the expression of O antigen by both LPS-rough and LPS-smooth isolates from cystic fibrosis patients. Mol Microbiol. 1994 Aug; 13(3):427-34. PMID: 7527892.
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  220. Shiro H, Muller E, Gutierrez N, Boisot S, Grout M, Tosteson TD, Goldmann D, Pier GB. Transposon mutants of Staphylococcus epidermidis deficient in elaboration of capsular polysaccharide/adhesin and slime are avirulent in a rabbit model of endocarditis. J Infect Dis. 1994 May; 169(5):1042-9. PMID: 8169389.
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  221. Fleiszig SM, Zaidi TS, Ramphal R, Pier GB. Modulation of Pseudomonas aeruginosa adherence to the corneal surface by mucus. Infect Immun. 1994 May; 62(5):1799-804. PMID: 8168942; PMCID: PMC186410.
  222. Pier GB, Koles NL, Meluleni G, Hatano K, Pollack M. Specificity and function of murine monoclonal antibodies and immunization-induced human polyclonal antibodies to lipopolysaccharide subtypes of Pseudomonas aeruginosa serogroup 06. Infect Immun. 1994 Apr; 62(4):1137-43. PMID: 8132318; PMCID: PMC186240.
  223. Huebner J, Pier GB, Maslow JN, Muller E, Shiro H, Parent M, Kropec A, Arbeit RD, Goldmann DA. Endemic nosocomial transmission of Staphylococcus epidermidis bacteremia isolates in a neonatal intensive care unit over 10 years. J Infect Dis. 1994 Mar; 169(3):526-31. PMID: 8158023.
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  224. Fleiszig SM, Zaidi TS, Pier GB. Mucus and Pseudomonas aeruginosa adherence to the cornea. Adv Exp Med Biol. 1994; 350:359-62. PMID: 8030502.
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  225. Muller E, Takeda S, Shiro H, Goldmann D, Pier GB. Occurrence of capsular polysaccharide/adhesin among clinical isolates of coagulase-negative staphylococci. J Infect Dis. 1993 Nov; 168(5):1211-8. PMID: 8228355.
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  226. Mai GT, McCormack JG, Seow WK, Pier GB, Jackson LA, Thong YH. Inhibition of adherence of mucoid Pseudomonas aeruginosa by alginase, specific monoclonal antibodies, and antibiotics. Infect Immun. 1993 Oct; 61(10):4338-43. PMID: 8406822; PMCID: PMC281163.
  227. Pittet JF, Matthay MA, Pier G, Grady M, Wiener-Kronish JP. Pseudomonas aeruginosa-induced lung and pleural injury in sheep. Differential protective effect of circulating versus alveolar immunoglobulin G antibody. J Clin Invest. 1993 Sep; 92(3):1221-8. PMID: 8376581; PMCID: PMC288261.
  228. Hatano K, Goldberg JB, Pier GB. Pseudomonas aeruginosa lipopolysaccharide: evidence that the O side chains and common antigens are on the same molecule. J Bacteriol. 1993 Aug; 175(16):5117-28. PMID: 7688717; PMCID: PMC204978.
  229. Goldmann DA, Pier GB. Pathogenesis of infections related to intravascular catheterization. Clin Microbiol Rev. 1993 Apr; 6(2):176-92. PMID: 8472248; PMCID: PMC358276.
  230. Goldberg JB, Hatano K, Pier GB. Synthesis of lipopolysaccharide O side chains by Pseudomonas aeruginosa PAO1 requires the enzyme phosphomannomutase. J Bacteriol. 1993 Mar; 175(6):1605-11. PMID: 8449870; PMCID: PMC203953.
  231. Pier GB, Takeda S, Grout M, Markham RB. Immune complexes from immunized mice and infected cystic fibrosis patients mediate murine and human T cell killing of hybridomas producing protective, opsonic antibody to Pseudomonas aeruginosa. J Clin Invest. 1993 Mar; 91(3):1079-87. PMID: 8450038; PMCID: PMC288062.
  232. Mai GT, Seow WK, Pier GB, McCormack JG, Thong YH. Suppression of lymphocyte and neutrophil functions by Pseudomonas aeruginosa mucoid exopolysaccharide (alginate): reversal by physicochemical, alginase, and specific monoclonal antibody treatments. Infect Immun. 1993 Feb; 61(2):559-64. PMID: 8423085; PMCID: PMC302764.
  233. Muller E, Hübner J, Gutierrez N, Takeda S, Goldmann DA, Pier GB. Isolation and characterization of transposon mutants of Staphylococcus epidermidis deficient in capsular polysaccharide/adhesin and slime. Infect Immun. 1993 Feb; 61(2):551-8. PMID: 8380794; PMCID: PMC302763.
  234. Goldberg JB, Hatano K, Meluleni GS, Pier GB. Cloning and surface expression of Pseudomonas aeruginosa O antigen in Escherichia coli. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10716-20. PMID: 1279692; PMCID: PMC50412.
  235. Pier GB, Meluleni G, Neuger E. A murine model of chronic mucosal colonization by Pseudomonas aeruginosa. Infect Immun. 1992 Nov; 60(11):4768-76. PMID: 1398987; PMCID: PMC258230.
  236. Fleiszig SM, Efron N, Pier GB. Extended contact lens wear enhances Pseudomonas aeruginosa adherence to human corneal epithelium. Invest Ophthalmol Vis Sci. 1992 Sep; 33(10):2908-16. PMID: 1526741.
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  237. Takeda S, Pier GB, Kojima Y, Tojo M, Muller E, Tosteson T, Goldmann DA. Protection against endocarditis due to Staphylococcus epidermidis by immunization with capsular polysaccharide/adhesin. Circulation. 1991 Dec; 84(6):2539-46. PMID: 1959203.
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  238. Pier GB, Grout M, Desjardins D. Complement deposition by antibodies to Pseudomonas aeruginosa mucoid exopolysaccharide (MEP) and by non-MEP specific opsonins. J Immunol. 1991 Sep 15; 147(6):1869-76. PMID: 1832427.
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  239. Muller E, Takeda S, Goldmann DA, Pier GB. Blood proteins do not promote adherence of coagulase-negative staphylococci to biomaterials. Infect Immun. 1991 Sep; 59(9):3323-6. PMID: 1879947; PMCID: PMC258175.
  240. Schreiber JR, Pier GB, Grout M, Nixon K, Patawaran M. Induction of opsonic antibodies to Pseudomonas aeruginosa mucoid exopolysaccharide by an anti-idiotypic monoclonal antibody. J Infect Dis. 1991 Sep; 164(3):507-14. PMID: 1831226.
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  241. Schreiber JR, Nixon KL, Tosi MF, Pier GB, Patawaran MB. Anti-idiotype-induced, lipopolysaccharide-specific antibody response to Pseudomonas aeruginosa. II. Isotype and functional activity of the anti-idiotype-induced antibodies. J Immunol. 1991 Jan 01; 146(1):188-93. PMID: 1898598.
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  242. Pier GB. Vaccine potential of Pseudomonas aeruginosa mucoid exopolysaccharide (alginate). Antibiot Chemother (1971). 1991; 44:136-42. PMID: 1801632.
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  243. Markham RB, Pier GB, Schreiber JR. The role of cytophilic IgG3 antibody in T cell-mediated resistance to infection with the extracellular bacterium, Pseudomonas aeruginosa. J Immunol. 1991 Jan 01; 146(1):316-20. PMID: 1898604.
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  244. Pollack M, Tao M, Akiyama M, Pier GB, Koles NL. In vitro and in vivo functional activities of monoclonal antibodies reactive with Pseudomonas aeruginosa serogroup 6 lipopolysaccharides. Antibiot Chemother (1971). 1991; 44:163-71. PMID: 1801635.
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  245. Pier GB, Small GJ, Warren HB. Protection against mucoid Pseudomonas aeruginosa in rodent models of endobronchial infections. Science. 1990 Aug 03; 249(4968):537-40. PMID: 2116663.
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  246. Kojima Y, Tojo M, Goldmann DA, Tosteson TD, Pier GB. Antibody to the capsular polysaccharide/adhesin protects rabbits against catheter-related bacteremia due to coagulase-negative staphylococci. J Infect Dis. 1990 Aug; 162(2):435-41. PMID: 2373873.
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  247. Garner CV, DesJardins D, Pier GB. Immunogenic properties of Pseudomonas aeruginosa mucoid exopolysaccharide. Infect Immun. 1990 Jun; 58(6):1835-42. PMID: 2140341; PMCID: PMC258732.
  248. Jones MM, Seilheimer DK, Pier GB, Rossen RD. Increased elastase secretion by peripheral blood monocytes in cystic fibrosis patients. Clin Exp Immunol. 1990 Jun; 80(3):344-9. PMID: 2142640; PMCID: PMC1535195.
  249. Schreiber JR, Patawaran M, Tosi M, Lennon J, Pier GB. Anti-idiotype-induced, lipopolysaccharide-specific antibody response to Pseudomonas aeruginosa. J Immunol. 1990 Feb 01; 144(3):1023-9. PMID: 2104908.
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  250. Kocharova NA, Hatano K, Shaskov AS, Knirel YA, Kochetkov NK, Pier GB. The structure and serologic distribution of an extracellular neutral polysaccharide from Pseudomonas aeruginosa immunotype 3. J Biol Chem. 1989 Sep 15; 264(26):15569-73. PMID: 2504722.
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  251. Pier GB, Pollack M. Isolation, structure, and immunogenicity of Pseudomonas aeruginosa immunotype 4 high-molecular-weight polysaccharide. Infect Immun. 1989 Feb; 57(2):426-31. PMID: 2492260; PMCID: PMC313114.
  252. Pier GB. Immunologic properties of Pseudomonas aeruginosa mucoid exopolysaccharide (alginate). Antibiot Chemother (1971). 1989; 42:80-7. PMID: 2512850.
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  253. Garner CV, Pier GB. Immunologic considerations for the development of conjugate vaccines. Contrib Microbiol Immunol. 1989; 10:11-7. PMID: 2510971.
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  254. Pier GB, Thomas D, Small G, Siadak A, Zweerink H. In vitro and in vivo activity of polyclonal and monoclonal human immunoglobulins G, M, and A against Pseudomonas aeruginosa lipopolysaccharide. Infect Immun. 1989 Jan; 57(1):174-9. PMID: 2491835; PMCID: PMC313063.
  255. Lukac M, Pier GB, Collier RJ. Toxoid of Pseudomonas aeruginosa exotoxin A generated by deletion of an active-site residue. Infect Immun. 1988 Dec; 56(12):3095-8. PMID: 2460407; PMCID: PMC259707.
  256. Markham RB, Pier GB, Powderly WG. Suppressor T cells regulating the cell-mediated immune response to Pseudomonas aeruginosa can be generated by immunization with anti-bacterial T cells. J Immunol. 1988 Dec 01; 141(11):3975-9. PMID: 2460554.
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  257. Vishwanath S, Ramphal R, Guay CM, DesJardins D, Pier GB. Respiratory-mucin inhibition of the opsonophagocytic killing of Pseudomonas aeruginosa. Infect Immun. 1988 Sep; 56(9):2218-22. PMID: 3137161; PMCID: PMC259552.
  258. Kocharova NA, Knirel YA, Shashkov AS, Kochetkov NK, Pier GB. Structure of an extracellular cross-reactive polysaccharide from Pseudomonas aeruginosa immunotype 4. J Biol Chem. 1988 Aug 15; 263(23):11291-5. PMID: 3136157.
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  259. Pier GB. Polysaccharide antigens of Pseudomonas aeruginosa. Rev Infect Dis. 1988 Jul-Aug; 10 Suppl 2:S337-40. PMID: 3142017.
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  260. Zweerink HJ, Gammon MC, Hutchison CF, Jackson JJ, Pier GB, Puckett JM, Sewell TJ, Sigal NH. X-linked immunodeficient mice as a model for testing the protective efficacy of monoclonal antibodies against Pseudomonas aeruginosa. Infect Immun. 1988 May; 56(5):1209-14. PMID: 3128480; PMCID: PMC259785.
  261. Powderly WG, Schreiber JR, Pier GB, Markham RB. T cells recognizing polysaccharide-specific B cells function as contrasuppressor cells in the generation of T cell immunity to Pseudomonas aeruginosa. J Immunol. 1988 Apr 15; 140(8):2746-52. PMID: 3128607.
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  262. Tojo M, Yamashita N, Goldmann DA, Pier GB. Isolation and characterization of a capsular polysaccharide adhesin from Staphylococcus epidermidis. J Infect Dis. 1988 Apr; 157(4):713-22. PMID: 3279138.
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  263. Lee JC, Perez NE, Hopkins CA, Pier GB. Purified capsular polysaccharide-induced immunity to Staphylococcus aureus infection. J Infect Dis. 1988 Apr; 157(4):723-30. PMID: 3346565.
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  264. Speert DP, Dimmick JE, Pier GB, Saunders JM, Hancock RE, Kelly N. An immunohistological evaluation of Pseudomonas aeruginosa pulmonary infection in two patients with cystic fibrosis. Pediatr Res. 1987 Dec; 22(6):743-7. PMID: 3431961.
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  265. Lee JC, Betley MJ, Hopkins CA, Perez NE, Pier GB. Virulence studies, in mice, of transposon-induced mutants of Staphylococcus aureus differing in capsule size. J Infect Dis. 1987 Nov; 156(5):741-50. PMID: 2821124.
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  266. Pier GB, Saunders JM, Ames P, Edwards MS, Auerbach H, Goldfarb J, Speert DP, Hurwitch S. Opsonophagocytic killing antibody to Pseudomonas aeruginosa mucoid exopolysaccharide in older noncolonized patients with cystic fibrosis. N Engl J Med. 1987 Sep 24; 317(13):793-8. PMID: 2957591.
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  267. Lee JC, Michon F, Perez NE, Hopkins CA, Pier GB. Chemical characterization and immunogenicity of capsular polysaccharide isolated from mucoid Staphylococcus aureus. Infect Immun. 1987 Sep; 55(9):2191-7. PMID: 3623697; PMCID: PMC260677.
  268. Parsonnet J, Gillis ZA, Richter AG, Pier GB. A rabbit model of toxic shock syndrome that uses a constant, subcutaneous infusion of toxic shock syndrome toxin 1. Infect Immun. 1987 May; 55(5):1070-6. PMID: 3570455; PMCID: PMC260470.
  269. Powderly WG, Pier GB, Markham RB. In vitro T cell-mediated killing of Pseudomonas aeruginosa. V. Generation of bactericidal T cells in nonresponder mice. J Immunol. 1987 Apr 01; 138(7):2272-7. PMID: 2951437.
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  270. Ramphal R, Guay C, Pier GB. Pseudomonas aeruginosa adhesins for tracheobronchial mucin. Infect Immun. 1987 Mar; 55(3):600-3. PMID: 2880808; PMCID: PMC260380.
  271. Pennington JE, Pier GB. [Pseudomonas aeruginosa immunoglobulin in experimental pneumonia]. Infection. 1987 Jan-Feb; 15(1):56-9. PMID: 3106230.
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  272. Pennington JE, Pier GB. [Pseudomonas aeruginosa immunoglobulin in experimental pneumonia]. Infection. 1987; 15 Suppl 2:S47-50. PMID: 3112020.
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  273. Pennington JE, Small GJ, Lostrom ME, Pier GB. Polyclonal and monoclonal antibody therapy for experimental Pseudomonas aeruginosa pneumonia. Infect Immun. 1986 Oct; 54(1):239-44. PMID: 3093385; PMCID: PMC260143.
  274. Powderly WG, Pier GB, Markham RB. In vitro T cell-mediated killing of Pseudomonas aeruginosa. IV. Nonresponsiveness in polysaccharide-immunized BALB/c mice is attributable to vinblastine-sensitive suppressor T cells. J Immunol. 1986 Sep 15; 137(6):2025-30. PMID: 2943808.
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  275. Stoll BJ, Pollack M, Young LS, Koles N, Gascon R, Pier GB. Functionally active monoclonal antibody that recognizes an epitope on the O side chain of Pseudomonas aeruginosa immunotype-1 lipopolysaccharide. Infect Immun. 1986 Sep; 53(3):656-62. PMID: 2427453; PMCID: PMC260844.
  276. Pier GB, Desjardins D, Aguilar T, Barnard M, Speert DP. Polysaccharide surface antigens expressed by nonmucoid isolates of Pseudomonas aeruginosa from cystic fibrosis patients. J Clin Microbiol. 1986 Aug; 24(2):189-96. PMID: 2943759; PMCID: PMC268873.
  277. Powderly WG, Pier GB, Markham RB. T lymphocyte-mediated protection against Pseudomonas aeruginosa infection in granulocytopenic mice. J Clin Invest. 1986 Aug; 78(2):375-80. PMID: 2426306; PMCID: PMC423557.
  278. Pennington JE, Pier GB, Sadoff JC, Small GJ. Active and passive immunization strategies for Pseudomonas aeruginosa pneumonia. Rev Infect Dis. 1986 Jul-Aug; 8 Suppl 4:S426-33. PMID: 2944209.
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  279. Parsonnet J, Gillis ZA, Pier GB. Induction of interleukin-1 by strains of Staphylococcus aureus from patients with nonmenstrual toxic shock syndrome. J Infect Dis. 1986 Jul; 154(1):55-63. PMID: 3486924.
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  280. Pier GB, Bennett SE. Structural analysis and immunogenicity of Pseudomonas aeruginosa immunotype 2 high molecular weight polysaccharide. J Clin Invest. 1986 Feb; 77(2):491-5. PMID: 3080477; PMCID: PMC423370.
  281. Noth JM, Barza M, Forster RK, Okumoto M, Pier G, Baum J. Serotyping of ocular Pseudomonas aeruginosa clinical isolates. Cornea. 1986; 5(3):151-3. PMID: 2980831.
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  282. Powderly WG, Pier GB, Markham RB. In vitro T cell-mediated killing of Pseudomonas aeruginosa. III. The role of suppressor T cells in nonresponder mice. J Immunol. 1986 Jan; 136(1):299-303. PMID: 2933465.
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  283. Pier GB. Terminology relating to extracellular polysaccharides produced by Pseudomonas aeruginosa. J Infect Dis. 1985 Sep; 152(3):652. PMID: 3928773.
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  284. Ames P, DesJardins D, Pier GB. Opsonophagocytic killing activity of rabbit antibody to Pseudomonas aeruginosa mucoid exopolysaccharide. Infect Immun. 1985 Aug; 49(2):281-5. PMID: 3160660; PMCID: PMC262011.
  285. Parsonnet J, Mills JT, Gillis ZA, Pier GB. Competitive, enzyme-linked immunosorbent assay for toxic shock syndrome toxin 1. J Clin Microbiol. 1985 Jul; 22(1):26-31. PMID: 3926815; PMCID: PMC268314.
  286. Markham RB, Pier GB, Goellner JJ, Mizel SB. In vitro T cell-mediated killing of Pseudomonas aeruginosa. II. The role of macrophages and T cell subsets in T cell killing. J Immunol. 1985 Jun; 134(6):4112-7. PMID: 3921618.
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  287. Daley L, Pier GB, Liporace JD, Eardley DD. Polyclonal B cell stimulation and interleukin 1 induction by the mucoid exopolysaccharide of Pseudomonas aeruginosa associated with cystic fibrosis. J Immunol. 1985 May; 134(5):3089-93. PMID: 3920310.
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  288. Pier GB. Pulmonary disease associated with Pseudomonas aeruginosa in cystic fibrosis: current status of the host-bacterium interaction. J Infect Dis. 1985 Apr; 151(4):575-80. PMID: 3919113.
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  289. Parsonnet J, Hickman RK, Eardley DD, Pier GB. Induction of human interleukin-1 by toxic-shock-syndrome toxin-1. J Infect Dis. 1985 Mar; 151(3):514-22. PMID: 3871826.
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  290. Pier GB. Pseudomonas aeruginosa surface polysaccharide vaccines. New therapeutic approaches from basic research. Antibiot Chemother (1971). 1985; 36:157-67. PMID: 3923913.
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  291. Ramphal R, Pier GB. Role of Pseudomonas aeruginosa mucoid exopolysaccharide in adherence to tracheal cells. Infect Immun. 1985 Jan; 47(1):1-4. PMID: 3155514; PMCID: PMC261445.
  292. Pier GB, Ames P. Mediation of the killing of rough, mucoid isolates of Pseudomonas aeruginosa from patients with cystic fibrosis by the alternative pathway of complement. J Infect Dis. 1984 Aug; 150(2):223-8. PMID: 6432921.
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  293. Markham RB, Goellner J, Pier GB. In vitro T cell-mediated killing of Pseudomonas aeruginosa. I. Evidence that a lymphokine mediates killing. J Immunol. 1984 Aug; 133(2):962-8. PMID: 6429246.
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  294. Pier GB, Elcock ME. Nonspecific immunoglobulin synthesis and elevated IgG levels in rabbits immunized with mucoid exopolysaccharide from cystic fibrosis isolates of Pseudomonas aeruginosa. J Immunol. 1984 Aug; 133(2):734-9. PMID: 6234359.
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  295. Pier GB, Pollack M, Cohen M. Immunochemical characterization of high-molecular-weight polysaccharide from Fisher immunotype 3 Pseudomonas aeruginosa. Infect Immun. 1984 Aug; 45(2):309-13. PMID: 6430805; PMCID: PMC263221.
  296. Pollack M, Pier GB, Prescott RK. Immunization with Pseudomonas aeruginosa high-molecular-weight polysaccharides prevents death from Pseudomonas burn infections in mice. Infect Immun. 1984 Feb; 43(2):759-60. PMID: 6420347; PMCID: PMC264367.
  297. Pier GB, Cohen M, Jennings H. Further purification and characterization of high-molecular-weight polysaccharide from Pseudomonas aeruginosa. Infect Immun. 1983 Dec; 42(3):936-41. PMID: 6417026; PMCID: PMC264389.
  298. Markham RB, Pier GB. Immunologic basis for mouse protection provided by high-molecular-weight polysaccharide from immunotype 1 Pseudomonas aeruginosa. Rev Infect Dis. 1983 Nov-Dec; 5 Suppl 5:S957-62. PMID: 6419317.
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  299. Pennington JE, Pier GB. Efficacy of cell wall Pseudomonas aeruginosa vaccines for protection against experimental pneumonia. Rev Infect Dis. 1983 Nov-Dec; 5 Suppl 5:S852-7. PMID: 6419311.
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  300. Pier GB. Immunochemistry of Pseudomonas aeruginosa lipopolysaccharides and high-molecular-weight polysaccharides. Rev Infect Dis. 1983 Nov-Dec; 5 Suppl 5:S950-6. PMID: 6197738.
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  301. Pier GB. Cystic fibrosis and Pseudomonas infections. Lancet. 1983 Oct 01; 2(8353):794. PMID: 6194393.
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  302. Hancock RE, Mutharia LM, Chan L, Darveau RP, Speert DP, Pier GB. Pseudomonas aeruginosa isolates from patients with cystic fibrosis: a class of serum-sensitive, nontypable strains deficient in lipopolysaccharide O side chains. Infect Immun. 1983 Oct; 42(1):170-7. PMID: 6413410; PMCID: PMC264539.
  303. Pier GB, Thomas DM. Characterization of the human immune response to a polysaccharide vaccine from Pseudomonas aeruginosa. J Infect Dis. 1983 Aug; 148(2):206-13. PMID: 6411830.
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  304. Markham RB, Pier GB. Characterization of the antibody response in inbred mice to a high-molecular-weight polysaccharide from Pseudomonas aeruginosa immunotype 1. Infect Immun. 1983 Jul; 41(1):232-6. PMID: 6407998; PMCID: PMC264768.
  305. Pier GB, Matthews WJ, Eardley DD. Immunochemical characterization of the mucoid exopolysaccharide of Pseudomonas aeruginosa. J Infect Dis. 1983 Mar; 147(3):494-503. PMID: 6220094.
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  306. Griffiss JM, Brandt BL, Altieri PL, Pier GB, Berman SL. Safety and immunogenicity of a group 29E meningococcal capsular polysaccharide vaccine in adults. Infect Immun. 1983 Jan; 39(1):247-52. PMID: 6401693; PMCID: PMC347933.
  307. Pier GB. Cross-protection by Pseudomonas aeruginosa polysaccharides. Infect Immun. 1982 Dec; 38(3):1117-22. PMID: 6185423; PMCID: PMC347865.
  308. Pier GB, Markham RB. Induction in mice of cell-mediated immunity to Pseudomonas aeruginosa by high molecular weight polysaccharide and vinblastine. J Immunol. 1982 May; 128(5):2121-5. PMID: 6174622.
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  309. Pier GB. Safety and immunogenicity of high molecular weight polysaccharide vaccine from immunotype 1 Pseudomonas aeruginosa. J Clin Invest. 1982 Feb; 69(2):303-8. PMID: 6799548; PMCID: PMC370979.
  310. Pier GB, Thomas DM. Lipopolysaccharide and high-molecular-weight polysaccharide serotypes of Pseudomonas aeruginosa. J Infect Dis. 1982 Feb; 145(2):217-23. PMID: 6798136.
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  311. Schneider H, Griffiss JM, Williams GD, Pier GB. Immunological basis of serum resistance of Neisseria gonorrhoeae. J Gen Microbiol. 1982 Jan; 128(1):13-22. PMID: 6806436.
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  312. Griffiss JM, Brandt BL, Altieri PL, Pier GB, Berman SL. Safety and immunogenicity of group Y and group W135 meningococcal capsular polysaccharide vaccines in adults. Infect Immun. 1981 Dec; 34(3):725-32. PMID: 6800954; PMCID: PMC350931.
  313. Pier GB, Sidberry HF, Sadoff JC. High-molecular-weight polysaccharide antigen from Pseudomonas aeruginosa immunotype 2. Infect Immun. 1981 Nov; 34(2):461-8. PMID: 6171520; PMCID: PMC350889.
  314. Pier GB, Markham RB, Eardley D. Correlation of the biologic responses of C3H/HEJ mice to endotoxin with the chemical and structural properties of the lipopolysaccharides from Pseudomonas aeruginosa and Escherichia coli. J Immunol. 1981 Jul; 127(1):184-91. PMID: 6787121.
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  315. Macone AB, Pier GB, Pennington JE, Matthews WJ, Goldmann DA. Mucoid Escherichia coli in cystic fibrosis. N Engl J Med. 1981 Jun 11; 304(24):1445-9. PMID: 6785645.
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  316. Brandt BL, Pier GB, Goroff DK, Altieri PL, Griffiss JM. Elaboration of both the group W135 and group Y capsular polysccharides by a single strain of Neisseria meningitidis. J Gen Microbiol. 1980 May; 118(1):39-43. PMID: 6775049.
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  317. Pier GB, Sidberry HF, Sadoff JC. Protective immunity induced in mice by immunization with high-molecular-weight polysaccharide from Pseudomonas aeruginosa. Infect Immun. 1978 Dec; 22(3):919-25. PMID: 103841; PMCID: PMC422244.
  318. Pier GB, Sidberry HF, Zolyomi S, Sadoff JC. Isolation and characterization of a high-molecular-weight polysaccharide from the slime of Pseudomonas aeruginosa. Infect Immun. 1978 Dec; 22(3):908-18. PMID: 103840; PMCID: PMC422243.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.