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Barbara Kahn, M.D.


Fructose Induced Insulin Resistance via Modulation of AMP-activated Kinase (AMPK) Levels
Summer, 06/15/09 - 08/11/09

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56DK110150 (KAHN, BARBARA B.) Sep 4, 2017 - Aug 31, 2018
    Preclinical Studies of Novel Anti-Diabetic Lipids
    Role: Principal Investigator
  2. R01DK106210 (KAHN, BARBARA B.) Apr 20, 2016 - Mar 31, 2021
    Regulation of the biosynthesis of a novel class of anti-diabetic lipids
    Role: Principal Investigator
  3. R01DK107405 (CHAIKOF, ELLIOT) Mar 1, 2016 - Feb 29, 2020
    A PSGL-1 Glycopeptide Mimetic for Treatment of Metabolic Syndrome
    Role: Co-Principal Investigator
  4. R01DK098002 (KAHN, BARBARA B) Feb 25, 2013 - Jan 31, 2017
    Metabolic effects of adipose lipogenesis
    Role: Principal Investigator
  5. R24DK083938 (KAHN, BARBARA B) Sep 8, 2009 - Aug 31, 2011
    Retinoid Biology, Insulin resistance, and Cardiac Dysfunction
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
BADERC Metabolic Physiology Core (HMS) - Core services (4) and Instruments (7)

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tan D, Ertunc ME, Konduri S, Zhang J, Pinto AM, Chu Q, Kahn BB, Siegel D, Saghatelian A. Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation. J Am Chem Soc. 2019 May 13. PMID: 31056915.
  2. Kahn BB. Adipose Tissue, Inter-Organ Communication, and the Path to Type 2 Diabetes: The 2016 Banting Medal for Scientific Achievement Lecture. Diabetes. 2019 01; 68(1):3-14. PMID: 30573674.
    Citations:    Fields:    
  3. Hammarstedt A, Syed I, Vijayakumar A, Eliasson B, Gogg S, Kahn BB, Smith U. Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids. Sci Rep. 2018 Oct 25; 8(1):15757. PMID: 30361530.
    Citations:    Fields:    
  4. Yang Q, Vijayakumar A, Kahn BB. Metabolites as regulators of insulin sensitivity and metabolism. Nat Rev Mol Cell Biol. 2018 Oct; 19(10):654-672. PMID: 30104701.
    Citations:    Fields:    
  5. Syed I, Lee J, Peroni OD, Yore MM, Moraes-Vieira PM, Santoro A, Wellenstein K, Smith U, McGraw TE, Saghatelian A, Kahn BB. Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects. Cell Metab. 2018 Oct 02; 28(4):543-546. PMID: 30244974.
    Citations:    Fields:    
  6. Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T, Rosen ED. Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. Cell Metab. 2018 Oct 02; 28(4):631-643.e3. PMID: 30078553.
    Citations:    Fields:    
  7. Kolar MJ, Nelson AT, Chang T, Ertunc ME, Christy MP, Ohlsson L, Härröd M, Kahn BB, Siegel D, Saghatelian A. Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements. Anal Chem. 2018 04 17; 90(8):5358-5365. PMID: 29578702.
    Citations:    Fields:    
  8. Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, Saghatelian A, Kahn BB. Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell Metab. 2018 02 06; 27(2):419-427.e4. PMID: 29414687.
    Citations: 3     Fields:    
  9. Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F, Ferré P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y. Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat. Cell Rep. 2018 01 16; 22(3):706-721. PMID: 29346768.
    Citations:    Fields:    
  10. Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB. Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. Cell Rep. 2017 Oct 24; 21(4):1021-1035. PMID: 29069585.
    Citations: 3     Fields:    Translation:AnimalsCells
  11. Nelson AT, Kolar MJ, Chu Q, Syed I, Kahn BB, Saghatelian A, Siegel D. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. J Am Chem Soc. 2017 04 05; 139(13):4943-4947. PMID: 28350171.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  12. McMillin SL, Schmidt DL, Kahn BB, Witczak CA. GLUT4 Is Not Necessary for Overload-Induced Glucose Uptake or Hypertrophic Growth in Mouse Skeletal Muscle. Diabetes. 2017 06; 66(6):1491-1500. PMID: 28279980.
    Citations:    Fields:    Translation:Animals
  13. Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Holm LM, Bäckhed F, Syed I, Bosch F, Saghatelian A, Kahn BB, Hammarstedt A, Smith U. Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance. Sci Rep. 2017 02 27; 7:43515. PMID: 28240264.
    Citations: 2     Fields:    Translation:AnimalsCells
  14. Reno CM, Puente EC, Sheng Z, Daphna-Iken D, Bree AJ, Routh VH, Kahn BB, Fisher SJ. Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation. Diabetes. 2017 03; 66(3):587-597. PMID: 27797912.
    Citations: 4     Fields:    Translation:AnimalsCells
  15. Smith U, Kahn BB. Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids. J Intern Med. 2016 11; 280(5):465-475. PMID: 27699898.
    Citations: 13     Fields:    Translation:HumansCells
  16. Lee J, Moraes-Vieira PM, Castoldi A, Aryal P, Yee EU, Vickers C, Parnas O, Donaldson CJ, Saghatelian A, Kahn BB. Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses. J Biol Chem. 2016 Oct 14; 291(42):22207-22217. PMID: 27573241.
    Citations: 7     Fields:    Translation:AnimalsCells
  17. Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A. Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry. 2016 08 23; 55(33):4636-41. PMID: 27509211.
    Citations: 3     Fields:    
  18. Lee SA, Yuen JJ, Jiang H, Kahn BB, Blaner WS. Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice. Hepatology. 2016 11; 64(5):1534-1546. PMID: 27227735.
    Citations: 8     Fields:    Translation:AnimalsCells
  19. Kong D, Dagon Y, Campbell JN, Guo Y, Yang Z, Yi X, Aryal P, Wellenstein K, Kahn BB, Sabatini BL, Lowell BB. A Postsynaptic AMPK?p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons. Neuron. 2016 07 06; 91(1):25-33. PMID: 27321921.
    Citations: 7     Fields:    Translation:AnimalsCells
  20. Moraes-Vieira PM, Saghatelian A, Kahn BB. GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects. Diabetes. 2016 07; 65(7):1808-15. PMID: 27288004.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  21. Parsons WH, Kolar MJ, Kamat SS, Cognetta AB, Hulce JJ, Saez E, Kahn BB, Saghatelian A, Cravatt BF. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nat Chem Biol. 2016 May; 12(5):367-372. PMID: 27018888.
    Citations: 4     Fields:    Translation:HumansCells
  22. Vazirani RP, Verma A, Sadacca LA, Buckman MS, Picatoste B, Beg M, Torsitano C, Bruno JH, Patel RT, Simonyte K, Camporez JP, Moreira G, Falcone DJ, Accili D, Elemento O, Shulman GI, Kahn BB, McGraw TE. Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance. Diabetes. 2016 06; 65(6):1577-89. PMID: 27207531.
    Citations: 5     Fields:    Translation:AnimalsCells
  23. Zhang T, Chen S, Syed I, Ståhlman M, Kolar MJ, Homan EA, Chu Q, Smith U, Borén J, Kahn BB, Saghatelian A. A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids. Nat Protoc. 2016 Apr; 11(4):747-63. PMID: 26985573.
    Citations: 6     Fields:    Translation:HumansAnimals
  24. Moraes-Vieira PM, Castoldi A, Aryal P, Wellenstein K, Peroni OD, Kahn BB. Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance. Diabetes. 2016 05; 65(5):1317-27. PMID: 26936962.
    Citations: 5     Fields:    Translation:AnimalsCells
  25. Henry MW, Miller AO, Kahn B, Windsor RE, Brause BD. Prosthetic joint infections secondary to rapidly growing mycobacteria: Two case reports and a review of the literature. Infect Dis (Lond). 2016; 48(6):453-60. PMID: 27030918.
    Citations:    Fields:    Translation:HumansCells
  26. Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. PKD1 Inhibits AMPKa2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. J Biol Chem. 2016 Mar 11; 291(11):5664-75. PMID: 26797128.
    Citations: 4     Fields:    Translation:AnimalsCells
  27. Kraus BJ, Sartoretto JL, Polak P, Hosooka T, Shiroto T, Eskurza I, Lee SA, Jiang H, Michel T, Kahn BB. Novel role for retinol-binding protein 4 in the regulation of blood pressure. FASEB J. 2015 Aug; 29(8):3133-40. PMID: 25911613.
    Citations: 4     Fields:    Translation:AnimalsCells
  28. Dodd GT, Decherf S, Loh K, Simonds SE, Wiede F, Balland E, Merry TL, Münzberg H, Zhang ZY, Kahn BB, Neel BG, Bence KK, Andrews ZB, Cowley MA, Tiganis T. Leptin and insulin act on POMC neurons to promote the browning of white fat. Cell. 2015 Jan 15; 160(1-2):88-104. PMID: 25594176.
    Citations: 63     Fields:    Translation:AnimalsCells
  29. Kraus D, Yang Q, Kahn BB. Lipid Extraction from Mouse Feces. Bio Protoc. 2015 Jan 05; 5(1). PMID: 27110587.
    Citations: 2     
  30. Zemany L, Bhanot S, Peroni OD, Murray SF, Moraes-Vieira PM, Castoldi A, Manchem P, Guo S, Monia BP, Kahn BB. Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice. Diabetes. 2015 May; 64(5):1603-14. PMID: 25524914.
    Citations: 15     Fields:    Translation:Animals
  31. Prothiwa M, Syed I, Huising MO, van der Meulen T, Donaldson CJ, Trauger SA, Kahn BB, Saghatelian A. Data-driven synthesis of proteolysis-resistant peptide hormones. J Am Chem Soc. 2014 Dec 24; 136(51):17710-3. PMID: 25496053.
    Citations: 1     Fields:    Translation:AnimalsCells
  32. Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 2014 Oct 09; 159(2):318-32. PMID: 25303528.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  33. Chiappini F, Catalano KJ, Lee J, Peroni OD, Lynch J, Dhaneshwar AS, Wellenstein K, Sontheimer A, Neel BG, Kahn BB. Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice. J Clin Invest. 2014 Sep; 124(9):3781-92. PMID: 25083988.
    Citations: 10     Fields:    Translation:Animals
  34. Kahn B, Collazo J, Kyprianou N. Androgen receptor as a driver of therapeutic resistance in advanced prostate cancer. Int J Biol Sci. 2014; 10(6):588-95. PMID: 24948871.
    Citations: 22     Fields:    Translation:Humans
  35. Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014 Apr 10; 508(7495):258-62. PMID: 24717514.
    Citations: 84     Fields:    Translation:AnimalsCells
  36. Moraes-Vieira PM, Yore MM, Dwyer PM, Syed I, Aryal P, Kahn BB. RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metab. 2014 Mar 04; 19(3):512-26. PMID: 24606904.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  37. Zemany L, Kraus BJ, Norseen J, Saito T, Peroni OD, Johnson RL, Kahn BB. Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo. Mol Cell Biol. 2014 Mar; 34(6):1170-86. PMID: 24421389.
    Citations: 11     Fields:    Translation:AnimalsCells
  38. Guzman J, Jauregui AN, Merscher-Gomez S, Maiguel D, Muresan C, Mitrofanova A, Diez-Sampedro A, Szust J, Yoo TH, Villarreal R, Pedigo C, Molano RD, Johnson K, Kahn B, Hartleben B, Huber TB, Saha J, Burke GW, Abel ED, Brosius FC, Fornoni A. Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy. Diabetes. 2014 Feb; 63(2):701-14. PMID: 24101677.
    Citations: 10     Fields:    Translation:AnimalsCells
  39. Kahn BB, Minokoshi Y. Leptin, GABA, and glucose control. Cell Metab. 2013 Sep 03; 18(3):304-6. PMID: 24011066.
    Citations:    Fields:    Translation:AnimalsCells
  40. Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integr Biol (Camb). 2013 Jul 24; 5(7):940-63. PMID: 23685806.
    Citations: 7     Fields:    Translation:Animals
  41. Kurland IJ, Accili D, Burant C, Fischer SM, Kahn BB, Newgard CB, Ramagiri S, Ronnett GV, Ryals JA, Sanders M, Shambaugh J, Shockcor J, Gross SS. Application of combined omics platforms to accelerate biomedical discovery in diabesity. Ann N Y Acad Sci. 2013 May; 1287:1-16. PMID: 23659636.
    Citations: 7     Fields:    Translation:HumansAnimals
  42. Sun Q, Kiernan UA, Shi L, Phillips DA, Kahn BB, Hu FB, Manson JE, Albert CM, Rexrode KM. Plasma retinol-binding protein 4 (RBP4) levels and risk of coronary heart disease: a prospective analysis among women in the nurses' health study. Circulation. 2013 May 14; 127(19):1938-47. PMID: 23584360.
    Citations: 23     Fields:    Translation:Humans
  43. Wu N, Zheng B, Shaywitz A, Dagon Y, Tower C, Bellinger G, Shen CH, Wen J, Asara J, McGraw TE, Kahn BB, Cantley LC. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Mol Cell. 2013 Mar 28; 49(6):1167-75. PMID: 23453806.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  44. Lee KY, Russell SJ, Ussar S, Boucher J, Vernochet C, Mori MA, Smyth G, Rourk M, Cederquist C, Rosen ED, Kahn BB, Kahn CR. Lessons on conditional gene targeting in mouse adipose tissue. Diabetes. 2013 Mar; 62(3):864-74. PMID: 23321074.
    Citations: 104     Fields:    Translation:AnimalsCells
  45. Hammarstedt A, Graham TE, Kahn BB. Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells. Diabetol Metab Syndr. 2012 Sep 19; 4(1):42. PMID: 22992414.
    Citations: 26     
  46. Dagon Y, Hur E, Zheng B, Wellenstein K, Cantley LC, Kahn BB. p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake. Cell Metab. 2012 Jul 03; 16(1):104-12. PMID: 22727014.
    Citations: 60     Fields:    Translation:AnimalsCells
  47. Kawashima J, Alquier T, Tsuji Y, Peroni OD, Kahn BB. Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia. PLoS One. 2012; 7(5):e36335. PMID: 22590531.
    Citations: 4     Fields:    Translation:AnimalsCells
  48. Herman MA, Peroni OD, Villoria J, Schön MR, Abumrad NA, Blüher M, Klein S, Kahn BB. A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature. 2012 Apr 19; 484(7394):333-8. PMID: 22466288.
    Citations: 137     Fields:    Translation:HumansAnimalsCells
  49. Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, Usheva A, Davis RJ, Smith U, Kahn BB. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol. 2012 May; 32(10):2010-9. PMID: 22431523.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  50. Owen C, Czopek A, Agouni A, Grant L, Judson R, Lees EK, Mcilroy GD, Göransson O, Welch A, Bence KK, Kahn BB, Neel BG, Mody N, Delibegovic M. Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis. PLoS One. 2012; 7(2):e32700. PMID: 22389718.
    Citations: 23     Fields:    Translation:AnimalsCells
  51. Myers MG, Heymsfield SB, Haft C, Kahn BB, Laughlin M, Leibel RL, Tschöp MH, Yanovski JA. Challenges and opportunities of defining clinical leptin resistance. Cell Metab. 2012 Feb 08; 15(2):150-6. PMID: 22326217.
    Citations: 50     Fields:    Translation:Humans
  52. Yang Q, Eskurza I, Kiernan UA, Phillips DA, Blüher M, Graham TE, Kahn BB. Quantitative measurement of full-length and C-terminal proteolyzed RBP4 in serum of normal and insulin-resistant humans using a novel mass spectrometry immunoassay. Endocrinology. 2012 Mar; 153(3):1519-27. PMID: 22253430.
    Citations: 11     Fields:    Translation:HumansCells
  53. Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E. A guide to analysis of mouse energy metabolism. Nat Methods. 2011 Dec 28; 9(1):57-63. PMID: 22205519.
    Citations: 203     Fields:    Translation:Animals
  54. Loh K, Fukushima A, Zhang X, Galic S, Briggs D, Enriori PJ, Simonds S, Wiede F, Reichenbach A, Hauser C, Sims NA, Bence KK, Zhang S, Zhang ZY, Kahn BB, Neel BG, Andrews ZB, Cowley MA, Tiganis T. Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metab. 2011 Nov 02; 14(5):684-99. PMID: 22000926.
    Citations: 48     Fields:    Translation:AnimalsCells
  55. Noriega LG, Feige JN, Canto C, Yamamoto H, Yu J, Herman MA, Mataki C, Kahn BB, Auwerx J. CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. EMBO Rep. 2011 Sep 30; 12(10):1069-76. PMID: 21836635.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  56. Pulinilkunnil T, He H, Kong D, Asakura K, Peroni OD, Lee A, Kahn BB. Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo. J Biol Chem. 2011 Mar 18; 286(11):8798-809. PMID: 21209093.
    Citations: 28     Fields:    Translation:AnimalsCells
  57. Kahn BB, McGraw TE. Rosiglitazone, PPAR?, and type 2 diabetes. N Engl J Med. 2010 Dec 30; 363(27):2667-9. PMID: 21190462.
    Citations: 18     Fields:    Translation:Cells
  58. Matsuo K, Delibegovic M, Matsuo I, Nagata N, Liu S, Bettaieb A, Xi Y, Araki K, Yang W, Kahn BB, Neel BG, Haj FG. Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2. J Biol Chem. 2010 Dec 17; 285(51):39750-8. PMID: 20841350.
    Citations: 14     Fields:    Translation:AnimalsCells
  59. Yang Z, Kahn BB, Shi H, Xue BZ. Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J Biol Chem. 2010 Jun 18; 285(25):19051-9. PMID: 20421294.
    Citations: 119     Fields:    Translation:HumansAnimalsCells
  60. Kraus D, Herman MA, Kahn BB. Leveraging leptin for type I diabetes? Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):4793-4. PMID: 20212134.
    Citations: 5     Fields:    Translation:HumansAnimals
  61. Herman MA, She P, Peroni OD, Lynch CJ, Kahn BB. Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. J Biol Chem. 2010 Apr 09; 285(15):11348-56. PMID: 20093359.
    Citations: 85     Fields:    Translation:Animals
  62. Jourdan M, Jaleel A, Karakelides H, Ford GC, Kahn BB, Nair KS. Impact of type 1 diabetes and insulin treatment on plasma levels and fractional synthesis rate of retinol-binding protein 4. J Clin Endocrinol Metab. 2009 Dec; 94(12):5125-30. PMID: 19850685.
    Citations: 3     Fields:    Translation:Humans
  63. Preitner F, Mody N, Graham TE, Peroni OD, Kahn BB. Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis. Am J Physiol Endocrinol Metab. 2009 Dec; 297(6):E1420-9. PMID: 19826103.
    Citations: 35     Fields:    Translation:Animals
  64. Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK. Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology. 2009 Nov; 150(11):4874-82. PMID: 19819947.
    Citations: 39     Fields:    Translation:AnimalsCells
  65. Stuck BJ, Kahn BB. Retinol-binding protein 4 (RBP4): a biomarker for subclinical atherosclerosis? Am J Hypertens. 2009 Sep; 22(9):948-9. PMID: 19701163.
    Citations: 3     Fields:    Translation:Humans
  66. Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med. 2009 Aug; 15(8):940-5. PMID: 19633655.
    Citations: 220     Fields:    Translation:HumansAnimalsCells
  67. Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, Kahn BB. Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues. Mol Cell Biol. 2009 Aug; 29(16):4563-73. PMID: 19528236.
    Citations: 30     Fields:    Translation:AnimalsCells
  68. Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong EG, Cho YR, Kim JK, Kahn BB, Neel BG, Bence KK. Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress. Diabetes. 2009 Mar; 58(3):590-9. PMID: 19074988.
    Citations: 86     Fields:    Translation:AnimalsCells
  69. Goodman E, Graham TE, Dolan LM, Daniels SR, Goodman ER, Kahn BB. The relationship of retinol binding protein 4 to changes in insulin resistance and cardiometabolic risk in overweight black adolescents. J Pediatr. 2009 Jan; 154(1):67-73.e1. PMID: 18783798.
    Citations: 9     Fields:    Translation:Humans
  70. Enjyoji K, Kotani K, Thukral C, Blumel B, Sun X, Wu Y, Imai M, Friedman D, Csizmadia E, Bleibel W, Kahn BB, Robson SC. Deletion of cd39/entpd1 results in hepatic insulin resistance. Diabetes. 2008 Sep; 57(9):2311-20. PMID: 18567823.
    Citations: 25     Fields:    Translation:AnimalsCells
  71. Krzyzanowska K, Zemany L, Krugluger W, Schernthaner GH, Mittermayer F, Schnack C, Rahman R, Brix J, Kahn BB, Schernthaner G. Serum concentrations of retinol-binding protein 4 in women with and without gestational diabetes. Diabetologia. 2008 Jul; 51(7):1115-22. PMID: 18437353.
    Citations: 14     Fields:    Translation:Humans
  72. Hammarstedt A, Pihlajamäki J, Graham TE, Kainulainen S, Kahn BB, Laakso M, Smith U. High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects. J Intern Med. 2008 Apr; 263(4):440-9. PMID: 18324929.
    Citations: 7     Fields:    Translation:Humans
  73. Mody N, Graham TE, Tsuji Y, Yang Q, Kahn BB. Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice. Am J Physiol Endocrinol Metab. 2008 Apr; 294(4):E785-93. PMID: 18285525.
    Citations: 28     Fields:    Translation:Animals
  74. Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem. 2008 May 23; 283(21):14230-41. PMID: 18281274.
    Citations: 104     Fields:    Translation:AnimalsCells
  75. Van Dyck F, Scroyen I, Declercq J, Sciot R, Kahn B, Lijnen R, Van de Ven WJ. aP2-Cre-mediated expression activation of an oncogenic PLAG1 transgene results in cavernous angiomatosis in mice. Int J Oncol. 2008 Jan; 32(1):33-40. PMID: 18097540.
    Citations: 4     Fields:    Translation:AnimalsCells
  76. Graham TE, Kahn BB. Tissue-specific alterations of glucose transport and molecular mechanisms of intertissue communication in obesity and type 2 diabetes. Horm Metab Res. 2007 Oct; 39(10):717-21. PMID: 17952832.
    Citations: 42     Fields:    Translation:HumansAnimals
  77. Kovacs P, Geyer M, Berndt J, Klöting N, Graham TE, Böttcher Y, Enigk B, Tönjes A, Schleinitz D, Schön MR, Kahn BB, Blüher M, Stumvoll M. Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression. Diabetes. 2007 Dec; 56(12):3095-100. PMID: 17728376.
    Citations: 24     Fields:    Translation:HumansCells
  78. Delibegovic M, Bence KK, Mody N, Hong EG, Ko HJ, Kim JK, Kahn BB, Neel BG. Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Mol Cell Biol. 2007 Nov; 27(21):7727-34. PMID: 17724080.
    Citations: 59     Fields:    Translation:AnimalsCells
  79. Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, Shi GP. Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol. 2007 Aug; 9(8):970-7. PMID: 17643114.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  80. Petersen KF, Dufour S, Savage DB, Bilz S, Solomon G, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Papademetris X, Rothman DL, Shulman GI. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31):12587-94. PMID: 17640906.
    Citations: 169     Fields:    Translation:Humans
  81. Yan QW, Yang Q, Mody N, Graham TE, Hsu CH, Xu Z, Houstis NE, Kahn BB, Rosen ED. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes. 2007 Oct; 56(10):2533-40. PMID: 17639021.
    Citations: 113     Fields:    Translation:AnimalsCells
  82. Klöting N, Graham TE, Berndt J, Kralisch S, Kovacs P, Wason CJ, Fasshauer M, Schön MR, Stumvoll M, Blüher M, Kahn BB. Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab. 2007 Jul; 6(1):79-87. PMID: 17618858.
    Citations: 108     Fields:    Translation:Humans
  83. Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. J Biol Chem. 2007 Aug 17; 282(33):23829-40. PMID: 17545163.
    Citations: 20     Fields:    Translation:AnimalsCells
  84. Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kim JK, Peroni OD, Kahn BB, Jain MK. Regulation of gluconeogenesis by Krüppel-like factor 15. Cell Metab. 2007 Apr; 5(4):305-12. PMID: 17403374.
    Citations: 68     Fields:    Translation:AnimalsCells
  85. Balagopal P, Graham TE, Kahn BB, Altomare A, Funanage V, George D. Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation. J Clin Endocrinol Metab. 2007 May; 92(5):1971-4. PMID: 17341558.
    Citations: 71     Fields:    Translation:Humans
  86. Kennedy AR, Pissios P, Otu H, Roberson R, Xue B, Asakura K, Furukawa N, Marino FE, Liu FF, Kahn BB, Libermann TA, Maratos-Flier E. A high-fat, ketogenic diet induces a unique metabolic state in mice. Am J Physiol Endocrinol Metab. 2007 Jun; 292(6):E1724-39. PMID: 17299079.
    Citations: 106     Fields:    Translation:Animals
  87. Graham TE, Wason CJ, Blüher M, Kahn BB. Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Diabetologia. 2007 Apr; 50(4):814-23. PMID: 17294166.
    Citations: 46     Fields:    Translation:Humans
  88. Alquier T, Kawashima J, Tsuji Y, Kahn BB. Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia. Endocrinology. 2007 Mar; 148(3):1367-75. PMID: 17185376.
    Citations: 31     Fields:    Translation:Animals
  89. Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med. 2006 Aug; 12(8):917-24. PMID: 16845389.
    Citations: 183     Fields:    Translation:AnimalsCells
  90. Herman MA, Kahn BB. Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest. 2006 Jul; 116(7):1767-75. PMID: 16823474.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  91. Graham TE, Yang Q, Blüher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson PA, Smith U, Kahn BB. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med. 2006 Jun 15; 354(24):2552-63. PMID: 16775236.
    Citations: 318     Fields:    Translation:HumansCells
  92. Kahn BB, Myers MG. mTOR tells the brain that the body is hungry. Nat Med. 2006 Jun; 12(6):615-7. PMID: 16761005.
    Citations: 12     Fields:    Translation:AnimalsCells
  93. Xue B, Kahn BB. AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol. 2006 Jul 01; 574(Pt 1):73-83. PMID: 16709629.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  94. Martin TL, Alquier T, Asakura K, Furukawa N, Preitner F, Kahn BB. Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. J Biol Chem. 2006 Jul 14; 281(28):18933-41. PMID: 16687413.
    Citations: 83     Fields:    Translation:Animals
  95. Kim YB, Peroni OD, Aschenbach WG, Minokoshi Y, Kotani K, Zisman A, Kahn CR, Goodyear LJ, Kahn BB. Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism. Mol Cell Biol. 2005 Nov; 25(21):9713-23. PMID: 16227617.
    Citations: 14     Fields:    Translation:AnimalsCells
  96. Furukawa N, Ongusaha P, Jahng WJ, Araki K, Choi CS, Kim HJ, Lee YH, Kaibuchi K, Kahn BB, Masuzaki H, Kim JK, Lee SW, Kim YB. Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab. 2005 Aug; 2(2):119-29. PMID: 16098829.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  97. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005 Jul 21; 436(7049):356-62. PMID: 16034410.
    Citations: 507     Fields:    Translation:AnimalsCells
  98. Carvalho E, Kotani K, Peroni OD, Kahn BB. Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle. Am J Physiol Endocrinol Metab. 2005 Oct; 289(4):E551-61. PMID: 15928024.
    Citations: 55     Fields:    Translation:Animals
  99. Jones JR, Barrick C, Kim KA, Lindner J, Blondeau B, Fujimoto Y, Shiota M, Kesterson RA, Kahn BB, Magnuson MA. Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A. 2005 Apr 26; 102(17):6207-12. PMID: 15833818.
    Citations: 141     Fields:    Translation:Animals
  100. Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005 Mar; 25(6):2498-510. PMID: 15743841.
    Citations: 50     Fields:    Translation:AnimalsCells
  101. Haj FG, Zabolotny JM, Kim YB, Kahn BB, Neel BG. Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice. J Biol Chem. 2005 Apr 15; 280(15):15038-46. PMID: 15699041.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  102. Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab. 2005 Feb; 1(2):107-19. PMID: 16054052.
    Citations: 137     Fields:    Translation:AnimalsCells
  103. Chimento GF, Pavone V, Sharrock N, Kahn B, Cahill J, Sculco TP. Minimally invasive total hip arthroplasty: a prospective randomized study. J Arthroplasty. 2005 Feb; 20(2):139-44. PMID: 15902851.
    Citations: 47     Fields:    Translation:HumansCTClinical Trials
  104. Galic S, Hauser C, Kahn BB, Haj FG, Neel BG, Tonks NK, Tiganis T. Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP. Mol Cell Biol. 2005 Jan; 25(2):819-29. PMID: 15632081.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  105. Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 2005 Jan; 1(1):15-25. PMID: 16054041.
    Citations: 766     Fields:    Translation:HumansAnimalsCells
  106. Collins S, Ahima RS, and Kahn BB. Biology of adipose tissue. In Joslin’s Diabetes Mellitus. CR Kahn, GC Weir, GL King, AC Moses, RJ Smith, AM Jacobson eds. 2005; 205-226.
  107. Corbould A, Kim YB, Youngren JF, Pender C, Kahn BB, Lee A, Dunaif A. Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling. Am J Physiol Endocrinol Metab. 2005 May; 288(5):E1047-54. PMID: 15613682.
    Citations: 45     Fields:    Translation:HumansCells
  108. Chan JL, Moschos SJ, Bullen J, Heist K, Li X, Kim YB, Kahn BB, Mantzoros CS. Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with relative leptin deficiency. J Clin Endocrinol Metab. 2005 Mar; 90(3):1625-31. PMID: 15613409.
    Citations: 18     Fields:    Translation:HumansCellsCTClinical Trials
  109. Kotani K, Peroni OD, Minokoshi Y, Boss O, Kahn BB. GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization. J Clin Invest. 2004 Dec; 114(11):1666-75. PMID: 15578099.
    Citations: 37     Fields:    Translation:HumansAnimals
  110. Morroni M, Giordano A, Zingaretti MC, Boiani R, De Matteis R, Kahn BB, Nisoli E, Tonello C, Pisoschi C, Luchetti MM, Marelli M, Cinti S. Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland. Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16801-6. PMID: 15556998.
    Citations: 26     Fields:    Translation:AnimalsCells
  111. Patti ME, Kahn BB. Nutrient sensor links obesity with diabetes risk. Nat Med. 2004 Oct; 10(10):1049-50. PMID: 15459705.
    Citations: 17     Fields:    Translation:AnimalsCells
  112. Alquier T, Kahn BB. Peripheral signals set the tone for central regulation of metabolism. Endocrinology. 2004 Sep; 145(9):4022-4. PMID: