Harvard Catalyst Profiles

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Barbara Kahn, M.D.

Title
Institution
Department
Address
Phone
Fax

Biography
education and training
Stanford University, Stanford, CABA1972Human Biology
University of California, Berkeley, CAMS1975Medical Science
Stanford University, Stanford, CAMD1977Medicine
Univ. of Calif., Davis Med. Ctr., Sacramento, CAIntern/Resident1977-80Internal Medicine
awards and honors
1980 - 1980
Biodynamics, Boehringer Mannelheim Research Award
1980 - 1980
Research Award
1981 - 1981
Faculty Research Award
1981
Research Award
1986 - 1991
Physician-Scientist Award
1991 - 1993
Capps Scholar in Diabetes
1992 - 1992
Award for "Outstanding International Contributions to Research in Diabetes Mellitus"
1993 - 1993
Max Miller Memorial Lecture
1994 - 1994
Elected to the American Society for Clinical Investigation
1995 - 1995
Eli Lilly Award for Outstanding Scientific Achievement
1999 - 1999
Elected to the Interurban Clinical Club
2000 - 2000
Honorary Masters Degree
2001 - 2001
Elected to the Association of American Physicians
2003 - 2003
Mosenthal Award
2003 - 2003
Wolfe Family endowed lectureship
2005 - 2005
Nelson Goldberg Lecture In Signal Transduction and Metabolism
2005 - 2005
Catherine Tuck Memorial Lecture
2005 - 2005
Elected to the Institute of Medicine (now the National Academy of Medicine)
2005 - 2005
The 10th Ray A. and Robert L. Kroc Lecture, Molecular Medicine
2005 - 2005
Charles H. Best Award, Department of Physiology
2005 - 2005
Jacobaeus Prize
2006 - 2006
MERIT Award
2006 - 2006
Elected Fellow
2006 - 2006
George Richards Minot Endowed Chair in Medicine
2006 - 2006
Research chosen for presentation
2007 - 2007
Research discoveries featured in the publication "NIDDK: Recent Advances and Emerging Opportunities"
2007 - 2007
Harold Rifkin Award and Lectureship
2008 - 2008
Dodge Lectureship
2008 - 2008
Roger Guillemin Nobel Lecturer
2009 - 2009
Inaugural Willard J and Priscilla F. Visek Lecturer
2010 - 2010
Beth Zaruby Lectureship at the Julia McFarlane Diabetes Research Center
2010 - 2010
Gerald Aubrach Award for outstanding contributions to research in Endocrinology
2010 - 2011
Edward, Frances and Shirley B. Daniels Fellow in Medical Sciences
2011 - 2011
15th Louis Izenstein Lectureship
2013 - 2013
Kern Lectureship Award
2013 - 2013
11th Albert Lehninger Award
2016 - 2016
Journal of Lipid Research Lectureship Award
2016 - 2016
Thorndike Lecture
2016 - 2016
Banting Medal for Outstanding Scientific Achievement
2016 - 2016
23rd Dewitt Goodman Lectureship
2017 - 2017
Charles Hollenberg Lectureship
2017 - 2017
Elected to the National Academy of Sciences
2017 - 2017
John Baxter Memorial Lecture
2018 - 2018
Nancy and Ann Hatfield Alumnae Award for outstanding contributions to the community
2019 - 2019
Excellence in Science Award
2019 - 2019
Elected to the American Academy of Arts and Sciences

Mentoring
completed student projects
Fructose Induced Insulin Resistance via Modulation of AMP-activated Kinase (AMPK) Levels
Summer, 06/15/09 - 08/11/09

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. R01DK106210 (KAHN, BARBARA B.) Apr 20, 2016 - Mar 31, 2025
    NIH
    Mechanisms for regulation of a novel class of anti-diabetic lipids
    Role: Principal Investigator
  2. R01DK107405 (CHAIKOF, ELLIOT) Mar 1, 2016 - Feb 28, 2021
    NIH
    A PSGL-1 Glycopeptide Mimetic for Treatment of Metabolic Syndrome
    Role: Co-Principal Investigator
  3. (KAHN, BARBARA B) Sep 1, 2012 - Jun 30, 2021
    JPB Foundation
    Characterization of a novel class of lipids involved in insulin sensitivity.
    Role Description: This grant investigates the biologic effects of a novel class of lipids involved in insulin sensitivity.
    Role: Principal Investigator
  4. P30DK057521 (FLOREZ, JOSE CARLOS) Jun 1, 2000 - Mar 31, 2021
    NIH
    Boston Area Diabetes Endocrinology Research Center
    Role: Co-Principal Investigator
  5. R01DK043051 (KAHN, BARBARA B.) Feb 1, 1992 - Jun 30, 2021
    NIH
    Glucose Transporter Regulation in Obesity and Diabetes
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rubin de Celis MF, Garcia-Martin R, Syed I, Lee J, Aguayo-Mazzucato C, Bonner-Weir S, Kahn BB. PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53. Proc Natl Acad Sci U S A. 2022 11 22; 119(47):e2206923119. PMID: 36375063; PMCID: PMC9704710.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  2. Loh K, Fukushima A, Zhang X, Galic S, Briggs D, Enriori PJ, Simonds S, Wiede F, Reichenbach A, Hauser C, Sims NA, Bence KK, Zhang S, Zhang ZY, Kahn BB, Neel BG, Andrews ZB, Cowley MA, Tiganis T. Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance. Cell Metab. 2022 Nov 01; 34(11):1892. PMID: 36323237; PMCID: PMC9719734.
    Citations:    Fields:    
  3. Patel R, Santoro A, Hofer P, Tan D, Oberer M, Nelson AT, Konduri S, Siegel D, Zechner R, Saghatelian A, Kahn BB. ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids. Nature. 2022 06; 606(7916):968-975. PMID: 35676490; PMCID: PMC9242854.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. DeVito LM, Dennis EA, Kahn BB, Shulman GI, Witztum JL, Sadhu S, Nickels J, Spite M, Smyth S, Spiegel S. Bioactive lipids and metabolic syndrome-a symposium report. Ann N Y Acad Sci. 2022 05; 1511(1):87-106. PMID: 35218041; PMCID: PMC9219555.
    Citations:    Fields:    Translation:HumansAnimals
  5. Dreyfuss JM, Yuchi Y, Dong X, Efthymiou V, Pan H, Simonson DC, Vernon A, Halperin F, Aryal P, Konkar A, Sebastian Y, Higgs BW, Grimsby J, Rondinone CM, Kasif S, Kahn BB, Foster K, Seeley R, Goldfine A, Djordjilovic V, Patti ME. High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control. Nat Commun. 2021 11 29; 12(1):6951. PMID: 34845204; PMCID: PMC8630169.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Aryal P, Syed I, Lee J, Patel R, Nelson AT, Siegel D, Saghatelian A, Kahn BB. Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs). J Lipid Res. 2021; 62:100108. PMID: 34418413; PMCID: PMC8479484.
    Citations: 1     Fields:    Translation:HumansCells
  7. Lee J, Vijayakumar A, White PJ, Xu Y, Ilkayeva O, Lynch CJ, Newgard CB, Kahn BB. BCAA Supplementation in Mice with Diet-induced Obesity Alters the Metabolome Without Impairing Glucose Homeostasis. Endocrinology. 2021 07 01; 162(7). PMID: 33765118; PMCID: PMC8183497.
    Citations: 3     Fields:    Translation:AnimalsCells
  8. McMillin SL, Stanley EC, Weyrauch LA, Brault JJ, Kahn BB, Witczak CA. Insulin Resistance Is Not Sustained Following Denervation in Glycolytic Skeletal Muscle. Int J Mol Sci. 2021 May 06; 22(9). PMID: 34066429; PMCID: PMC8125496.
    Citations:    Fields:    Translation:AnimalsCells
  9. Santoro A, McGraw TE, Kahn BB. Insulin action in adipocytes, adipose remodeling, and systemic effects. Cell Metab. 2021 04 06; 33(4):748-757. PMID: 33826917; PMCID: PMC8078167.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  10. Moraes-Vieira PM, Yore MM, Sontheimer-Phelps A, Castoldi A, Norseen J, Aryal P, Simonyté Sjödin K, Kahn BB. Retinol binding protein 4 primes the NLRP3 inflammasome by signaling through Toll-like receptors 2 and 4. Proc Natl Acad Sci U S A. 2020 12 08; 117(49):31309-31318. PMID: 33214151.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  11. Hall JA, Ramachandran D, Roh HC, DiSpirito JR, Belchior T, Zushin PH, Palmer C, Hong S, Mina AI, Liu B, Deng Z, Aryal P, Jacobs C, Tenen D, Brown CW, Charles JF, Shulman GI, Kahn BB, Tsai LTY, Rosen ED, Spiegelman BM, Banks AS. Obesity-Linked PPAR? S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3. Cell Metab. 2020 10 06; 32(4):665-675.e6. PMID: 32941798.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  12. Kilicarslan M, de Weijer BA, Simonyté Sjödin K, Aryal P, Ter Horst KW, Cakir H, Romijn JA, Ackermans MT, Janssen IM, Berends FJ, van de Laar AW, Houdijk AP, Kahn BB, Serlie MJ. RBP4 increases lipolysis in human adipocytes and is associated with increased lipolysis and hepatic insulin resistance in obese women. FASEB J. 2020 05; 34(5):6099-6110. PMID: 32167208; PMCID: PMC7317205.
    Citations: 12     Fields:    Translation:HumansCells
  13. Zhou P, Santoro A, Peroni OD, Nelson AT, Saghatelian A, Siegel D, Kahn BB. PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms. J Clin Invest. 2019 10 01; 129(10):4138-4150. PMID: 31449056; PMCID: PMC6763232.
    Citations: 27     Fields:    Translation:AnimalsCells
  14. Syed I, Rubin de Celis MF, Mohan JF, Moraes-Vieira PM, Vijayakumar A, Nelson AT, Siegel D, Saghatelian A, Mathis D, Kahn BB. PAHSAs attenuate immune responses and promote ß cell survival in autoimmune diabetic mice. J Clin Invest. 2019 08 05; 129(9):3717-3731. PMID: 31380811; PMCID: PMC6715391.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  15. Tan D, Ertunc ME, Konduri S, Zhang J, Pinto AM, Chu Q, Kahn BB, Siegel D, Saghatelian A. Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation. J Am Chem Soc. 2019 06 05; 141(22):8798-8806. PMID: 31056915; PMCID: PMC6662584.
    Citations: 14     Fields:    Translation:AnimalsCells
  16. Kahn BB. Adipose Tissue, Inter-Organ Communication, and the Path to Type 2 Diabetes: The 2016 Banting Medal for Scientific Achievement Lecture. Diabetes. 2019 01; 68(1):3-14. PMID: 30573674; PMCID: PMC6302542.
    Citations: 14     Fields:    Translation:HumansAnimals
  17. Hammarstedt A, Syed I, Vijayakumar A, Eliasson B, Gogg S, Kahn BB, Smith U. Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids. Sci Rep. 2018 10 25; 8(1):15757. PMID: 30361530.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  18. Yang Q, Vijayakumar A, Kahn BB. Metabolites as regulators of insulin sensitivity and metabolism. Nat Rev Mol Cell Biol. 2018 10; 19(10):654-672. PMID: 30104701; PMCID: PMC6380503.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  19. Syed I, Lee J, Peroni OD, Yore MM, Moraes-Vieira PM, Santoro A, Wellenstein K, Smith U, McGraw TE, Saghatelian A, Kahn BB. Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects. Cell Metab. 2018 10 02; 28(4):543-546. PMID: 30244974; PMCID: PMC6542592.
    Citations: 13     Fields:    Translation:Animals
  20. Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T, Rosen ED. Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. Cell Metab. 2018 10 02; 28(4):631-643.e3. PMID: 30078553; PMCID: PMC6170693.
    Citations: 60     Fields:    Translation:AnimalsCells
  21. Kolar MJ, Nelson AT, Chang T, Ertunc ME, Christy MP, Ohlsson L, Härröd M, Kahn BB, Siegel D, Saghatelian A. Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements. Anal Chem. 2018 04 17; 90(8):5358-5365. PMID: 29578702; PMCID: PMC5962352.
    Citations: 15     Fields:    Translation:Cells
  22. Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, Saghatelian A, Kahn BB. Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell Metab. 2018 02 06; 27(2):419-427.e4. PMID: 29414687.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  23. Okamoto S, Sato T, Tateyama M, Kageyama H, Maejima Y, Nakata M, Hirako S, Matsuo T, Kyaw S, Shiuchi T, Toda C, Sedbazar U, Saito K, Asgar NF, Zhang B, Yokota S, Kobayashi K, Foufelle F, Ferré P, Nakazato M, Masuzaki H, Shioda S, Yada T, Kahn BB, Minokoshi Y. Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat. Cell Rep. 2018 01 16; 22(3):706-721. PMID: 29346768.
    Citations: 22     Fields:    Translation:AnimalsCells
  24. Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB. Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. Cell Rep. 2017 Oct 24; 21(4):1021-1035. PMID: 29069585; PMCID: PMC5771491.
    Citations: 48     Fields:    Translation:AnimalsCells
  25. Nelson AT, Kolar MJ, Chu Q, Syed I, Kahn BB, Saghatelian A, Siegel D. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. J Am Chem Soc. 2017 04 05; 139(13):4943-4947. PMID: 28350171; PMCID: PMC5568760.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  26. McMillin SL, Schmidt DL, Kahn BB, Witczak CA. GLUT4 Is Not Necessary for Overload-Induced Glucose Uptake or Hypertrophic Growth in Mouse Skeletal Muscle. Diabetes. 2017 06; 66(6):1491-1500. PMID: 28279980; PMCID: PMC5440020.
    Citations: 8     Fields:    Translation:Animals
  27. Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Holm LM, Bäckhed F, Syed I, Bosch F, Saghatelian A, Kahn BB, Hammarstedt A, Smith U. Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance. Sci Rep. 2017 02 27; 7:43515. PMID: 28240264.
    Citations: 11     Fields:    Translation:AnimalsCells
  28. Reno CM, Puente EC, Sheng Z, Daphna-Iken D, Bree AJ, Routh VH, Kahn BB, Fisher SJ. Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation. Diabetes. 2017 03; 66(3):587-597. PMID: 27797912; PMCID: PMC5319720.
    Citations: 40     Fields:    Translation:AnimalsCells
  29. Smith U, Kahn BB. Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids. J Intern Med. 2016 11; 280(5):465-475. PMID: 27699898; PMCID: PMC5218584.
    Citations: 135     Fields:    Translation:HumansCells
  30. Lee J, Moraes-Vieira PM, Castoldi A, Aryal P, Yee EU, Vickers C, Parnas O, Donaldson CJ, Saghatelian A, Kahn BB. Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses. J Biol Chem. 2016 Oct 14; 291(42):22207-22217. PMID: 27573241.
    Citations: 49     Fields:    Translation:AnimalsCells
  31. Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A. Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry. 2016 08 23; 55(33):4636-41. PMID: 27509211.
    Citations: 26     Fields:    
  32. Lee SA, Yuen JJ, Jiang H, Kahn BB, Blaner WS. Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice. Hepatology. 2016 11; 64(5):1534-1546. PMID: 27227735.
    Citations: 34     Fields:    Translation:AnimalsCells
  33. Kong D, Dagon Y, Campbell JN, Guo Y, Yang Z, Yi X, Aryal P, Wellenstein K, Kahn BB, Sabatini BL, Lowell BB. A Postsynaptic AMPK?p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons. Neuron. 2016 07 06; 91(1):25-33. PMID: 27321921; PMCID: PMC4938763.
    Citations: 28     Fields:    Translation:AnimalsCells
  34. Moraes-Vieira PM, Saghatelian A, Kahn BB. GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects. Diabetes. 2016 07; 65(7):1808-15. PMID: 27288004; PMCID: PMC4915575.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  35. Parsons WH, Kolar MJ, Kamat SS, Cognetta AB, Hulce JJ, Saez E, Kahn BB, Saghatelian A, Cravatt BF. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nat Chem Biol. 2016 May; 12(5):367-372. PMID: 27018888; PMCID: PMC4837090.
    Citations: 30     Fields:    Translation:HumansCells
  36. Vazirani RP, Verma A, Sadacca LA, Buckman MS, Picatoste B, Beg M, Torsitano C, Bruno JH, Patel RT, Simonyte K, Camporez JP, Moreira G, Falcone DJ, Accili D, Elemento O, Shulman GI, Kahn BB, McGraw TE. Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance. Diabetes. 2016 06; 65(6):1577-89. PMID: 27207531; PMCID: PMC4878419.
    Citations: 22     Fields:    Translation:AnimalsCells
  37. Zhang T, Chen S, Syed I, Ståhlman M, Kolar MJ, Homan EA, Chu Q, Smith U, Borén J, Kahn BB, Saghatelian A. A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids. Nat Protoc. 2016 Apr; 11(4):747-63. PMID: 26985573.
    Citations: 26     Fields:    Translation:HumansAnimals
  38. Moraes-Vieira PM, Castoldi A, Aryal P, Wellenstein K, Peroni OD, Kahn BB. Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance. Diabetes. 2016 05; 65(5):1317-27. PMID: 26936962; PMCID: PMC4839203.
    Citations: 21     Fields:    Translation:AnimalsCells
  39. Henry MW, Miller AO, Kahn B, Windsor RE, Brause BD. Prosthetic joint infections secondary to rapidly growing mycobacteria: Two case reports and a review of the literature. Infect Dis (Lond). 2016; 48(6):453-60. PMID: 27030918.
    Citations: 5     Fields:    Translation:HumansCells
  40. Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. PKD1 Inhibits AMPKa2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. J Biol Chem. 2016 Mar 11; 291(11):5664-5675. PMID: 26797128.
    Citations: 19     Fields:    Translation:AnimalsCells
  41. Kraus BJ, Sartoretto JL, Polak P, Hosooka T, Shiroto T, Eskurza I, Lee SA, Jiang H, Michel T, Kahn BB. Novel role for retinol-binding protein 4 in the regulation of blood pressure. FASEB J. 2015 Aug; 29(8):3133-40. PMID: 25911613; PMCID: PMC4511195.
    Citations: 19     Fields:    Translation:AnimalsCells
  42. Dodd GT, Decherf S, Loh K, Simonds SE, Wiede F, Balland E, Merry TL, Münzberg H, Zhang ZY, Kahn BB, Neel BG, Bence KK, Andrews ZB, Cowley MA, Tiganis T. Leptin and insulin act on POMC neurons to promote the browning of white fat. Cell. 2015 Jan 15; 160(1-2):88-104. PMID: 25594176.
    Citations: 151     Fields:    Translation:AnimalsCells
  43. Kraus D, Yang Q, Kahn BB. Lipid Extraction from Mouse Feces. Bio Protoc. 2015 Jan 05; 5(1). PMID: 27110587; PMCID: PMC4838042.
    Citations: 31     
  44. Zemany L, Bhanot S, Peroni OD, Murray SF, Moraes-Vieira PM, Castoldi A, Manchem P, Guo S, Monia BP, Kahn BB. Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice. Diabetes. 2015 May; 64(5):1603-14. PMID: 25524914; PMCID: PMC4407860.
    Citations: 26     Fields:    Translation:Animals
  45. Prothiwa M, Syed I, Huising MO, van der Meulen T, Donaldson CJ, Trauger SA, Kahn BB, Saghatelian A. Data-driven synthesis of proteolysis-resistant peptide hormones. J Am Chem Soc. 2014 Dec 24; 136(51):17710-3. PMID: 25496053.
    Citations: 2     Fields:    Translation:AnimalsCells
  46. Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 2014 Oct 09; 159(2):318-32. PMID: 25303528.
    Citations: 269     Fields:    Translation:HumansAnimalsCells
  47. Chiappini F, Catalano KJ, Lee J, Peroni OD, Lynch J, Dhaneshwar AS, Wellenstein K, Sontheimer A, Neel BG, Kahn BB. Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice. J Clin Invest. 2014 Sep; 124(9):3781-92. PMID: 25083988; PMCID: PMC4151212.
    Citations: 14     Fields:    Translation:Animals
  48. Kahn B, Collazo J, Kyprianou N. Androgen receptor as a driver of therapeutic resistance in advanced prostate cancer. Int J Biol Sci. 2014; 10(6):588-95. PMID: 24948871.
    Citations: 38     Fields:    Translation:Humans
  49. Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014 Apr 10; 508(7495):258-62. PMID: 24717514; PMCID: PMC4107212.
    Citations: 195     Fields:    Translation:AnimalsCells
  50. Moraes-Vieira PM, Yore MM, Dwyer PM, Syed I, Aryal P, Kahn BB. RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metab. 2014 Mar 04; 19(3):512-26. PMID: 24606904; PMCID: PMC4078000.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  51. Zemany L, Kraus BJ, Norseen J, Saito T, Peroni OD, Johnson RL, Kahn BB. Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo. Mol Cell Biol. 2014 Mar; 34(6):1170-86. PMID: 24421389.
    Citations: 18     Fields:    Translation:AnimalsCells
  52. Guzman J, Jauregui AN, Merscher-Gomez S, Maiguel D, Muresan C, Mitrofanova A, Diez-Sampedro A, Szust J, Yoo TH, Villarreal R, Pedigo C, Molano RD, Johnson K, Kahn B, Hartleben B, Huber TB, Saha J, Burke GW, Abel ED, Brosius FC, Fornoni A. Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy. Diabetes. 2014 Feb; 63(2):701-14. PMID: 24101677; PMCID: PMC3900538.
    Citations: 27     Fields:    Translation:AnimalsCells
  53. Kahn BB, Minokoshi Y. Leptin, GABA, and glucose control. Cell Metab. 2013 Sep 03; 18(3):304-6. PMID: 24011066.
    Citations: 3     Fields:    Translation:AnimalsCells
  54. Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integr Biol (Camb). 2013 Jul 24; 5(7):940-63. PMID: 23685806.
    Citations: 9     Fields:    Translation:Animals
  55. Kurland IJ, Accili D, Burant C, Fischer SM, Kahn BB, Newgard CB, Ramagiri S, Ronnett GV, Ryals JA, Sanders M, Shambaugh J, Shockcor J, Gross SS. Application of combined omics platforms to accelerate biomedical discovery in diabesity. Ann N Y Acad Sci. 2013 May; 1287:1-16. PMID: 23659636.
    Citations: 11     Fields:    Translation:HumansAnimals
  56. Sun Q, Kiernan UA, Shi L, Phillips DA, Kahn BB, Hu FB, Manson JE, Albert CM, Rexrode KM. Plasma retinol-binding protein 4 (RBP4) levels and risk of coronary heart disease: a prospective analysis among women in the nurses' health study. Circulation. 2013 May 14; 127(19):1938-47. PMID: 23584360; PMCID: PMC3741657.
    Citations: 49     Fields:    Translation:Humans
  57. Wu N, Zheng B, Shaywitz A, Dagon Y, Tower C, Bellinger G, Shen CH, Wen J, Asara J, McGraw TE, Kahn BB, Cantley LC. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Mol Cell. 2013 Mar 28; 49(6):1167-75. PMID: 23453806.
    Citations: 240     Fields:    Translation:HumansAnimalsCells
  58. Lee KY, Russell SJ, Ussar S, Boucher J, Vernochet C, Mori MA, Smyth G, Rourk M, Cederquist C, Rosen ED, Kahn BB, Kahn CR. Lessons on conditional gene targeting in mouse adipose tissue. Diabetes. 2013 Mar; 62(3):864-74. PMID: 23321074; PMCID: PMC3581196.
    Citations: 178     Fields:    Translation:AnimalsCells
  59. Hammarstedt A, Graham TE, Kahn BB. Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells. Diabetol Metab Syndr. 2012 Sep 19; 4(1):42. PMID: 22992414.
    Citations: 47     
  60. Dagon Y, Hur E, Zheng B, Wellenstein K, Cantley LC, Kahn BB. p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake. Cell Metab. 2012 Jul 03; 16(1):104-12. PMID: 22727014.
    Citations: 106     Fields:    Translation:AnimalsCells
  61. Kawashima J, Alquier T, Tsuji Y, Peroni OD, Kahn BB. Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia. PLoS One. 2012; 7(5):e36335. PMID: 22590531; PMCID: PMC3349669.
    Citations: 6     Fields:    Translation:AnimalsCells
  62. Herman MA, Peroni OD, Villoria J, Schön MR, Abumrad NA, Blüher M, Klein S, Kahn BB. A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature. 2012 Apr 19; 484(7394):333-8. PMID: 22466288.
    Citations: 262     Fields:    Translation:HumansAnimalsCells
  63. Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, Usheva A, Davis RJ, Smith U, Kahn BB. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol. 2012 May; 32(10):2010-9. PMID: 22431523.
    Citations: 116     Fields: &nbs