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profileBarbara Kahn, M.D.

TitleGeorge Richards Minot Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
E/cls 747
330 Brookline Ave
Boston MA 02215
Phone617/735-3324
Fax617/735-3323
vCardDownload vCard (login for email)

Collapse Mentoring 
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Fructose Induced Insulin Resistance via Modulation of AMP-activated Kinase (AMPK) Levels
Summer, 06/15/09 - 08/11/09

Collapse Research 
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R56DK110150     (KAHN, BARBARA B.)Sep 4, 2017 - Aug 31, 2018
NIH/NIDDK
Preclinical Studies of Novel Anti-Diabetic Lipids
Role: Principal Investigator

R01DK106210     (KAHN, BARBARA B)Apr 20, 2016 - Mar 31, 2021
NIH/NIDDK
Regulation of the biosynthesis of a novel class of anti-diabetic lipids
Role: Principal Investigator

R01DK107405     (CHAIKOF, ELLIOT)Mar 1, 2016 - Feb 29, 2020
NIH/NIDDK
A PSGL-1 Glycopeptide Mimetic for Treatment of Metabolic Syndrome
Role: Co-Principal Investigator

R01DK098002     (KAHN, BARBARA B)Feb 25, 2013 - Jan 31, 2017
NIH/NIDDK
Metabolic effects of adipose lipogenesis
Role: Principal Investigator

R24DK083938     (KAHN, BARBARA B)Sep 8, 2009 - Aug 31, 2011
NIH/NIDDK
Retinoid Biology, Insulin resistance, and Cardiac Dysfunction
Role: Principal Investigator
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in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
BADERC Metabolic Physiology Core (HMS) - Core services (6) and Instruments (3)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nelson AT, Kolar MJ, Chu Q, Syed I, Kahn BB, Saghatelian A, Siegel D. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation. J Am Chem Soc. 2017 Apr 05; 139(13):4943-4947. PMID: 28350171.
    View in: PubMed
  2. McMillin SL, Schmidt DL, Kahn BB, Witczak CA. GLUT4 Is Not Necessary for Overload-Induced Glucose Uptake or Hypertrophic Growth in Mouse Skeletal Muscle. Diabetes. 2017 Jun; 66(6):1491-1500. PMID: 28279980.
    View in: PubMed
  3. Grünberg JR, Hoffmann JM, Hedjazifar S, Nerstedt A, Jenndahl L, Elvin J, Castellot J, Wei L, Movérare-Skrtic S, Ohlsson C, Holm LM, Bäckhed F, Syed I, Bosch F, Saghatelian A, Kahn BB, Hammarstedt A, Smith U. Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance. Sci Rep. 2017 Feb 27; 7:43515. PMID: 28240264.
    View in: PubMed
  4. Reno CM, Puente EC, Sheng Z, Daphna-Iken D, Bree AJ, Routh VH, Kahn BB, Fisher SJ. Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation. Diabetes. 2017 Mar; 66(3):587-597. PMID: 27797912.
    View in: PubMed
  5. Smith U, Kahn BB. Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids. J Intern Med. 2016 Nov; 280(5):465-475. PMID: 27699898.
    View in: PubMed
  6. Lee J, Moraes-Vieira PM, Castoldi A, Aryal P, Yee EU, Vickers C, Parnas O, Donaldson CJ, Saghatelian A, Kahn BB. Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses. J Biol Chem. 2016 Oct 14; 291(42):22207-22217. PMID: 27573241.
    View in: PubMed
  7. Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A. Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry. 2016 Aug 23; 55(33):4636-41. PMID: 27509211.
    View in: PubMed
  8. Lee SA, Yuen JJ, Jiang H, Kahn BB, Blaner WS. Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice. Hepatology. 2016 Nov; 64(5):1534-1546. PMID: 27227735.
    View in: PubMed
  9. Kong D, Dagon Y, Campbell JN, Guo Y, Yang Z, Yi X, Aryal P, Wellenstein K, Kahn BB, Sabatini BL, Lowell BB. A Postsynaptic AMPK?p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons. Neuron. 2016 Jul 06; 91(1):25-33. PMID: 27321921; PMCID: PMC4938763 [Available on 07/06/17].
  10. Moraes-Vieira PM, Saghatelian A, Kahn BB. GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects. Diabetes. 2016 Jul; 65(7):1808-15. PMID: 27288004; PMCID: PMC4915575 [Available on 07/01/17].
  11. Parsons WH, Kolar MJ, Kamat SS, Cognetta AB, Hulce JJ, Saez E, Kahn BB, Saghatelian A, Cravatt BF. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nat Chem Biol. 2016 May; 12(5):367-372. PMID: 27018888; PMCID: PMC4837090.
  12. Vazirani RP, Verma A, Sadacca LA, Buckman MS, Picatoste B, Beg M, Torsitano C, Bruno JH, Patel RT, Simonyte K, Camporez JP, Moreira G, Falcone DJ, Accili D, Elemento O, Shulman GI, Kahn BB, McGraw TE. Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance. Diabetes. 2016 Jun; 65(6):1577-89. PMID: 27207531; PMCID: PMC4878419 [Available on 06/01/17].
  13. Zhang T, Chen S, Syed I, Ståhlman M, Kolar MJ, Homan EA, Chu Q, Smith U, Borén J, Kahn BB, Saghatelian A. A LC-MS-based workflow for measurement of branched fatty acid esters of hydroxy fatty acids. Nat Protoc. 2016 Apr; 11(4):747-63. PMID: 26985573; PMCID: PMC4797065 [Available on 10/01/16].
  14. Moraes-Vieira PM, Castoldi A, Aryal P, Wellenstein K, Peroni OD, Kahn BB. Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance. Diabetes. 2016 May; 65(5):1317-27. PMID: 26936962; PMCID: PMC4839203 [Available on 05/01/17].
  15. Henry MW, Miller AO, Kahn B, Windsor RE, Brause BD. Prosthetic joint infections secondary to rapidly growing mycobacteria: Two case reports and a review of the literature. Infect Dis (Lond). 2016; 48(6):453-60. PMID: 27030918.
    View in: PubMed
  16. Coughlan KA, Valentine RJ, Sudit BS, Allen K, Dagon Y, Kahn BB, Ruderman NB, Saha AK. PKD1 Inhibits AMPKa2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells. J Biol Chem. 2016 Mar 11; 291(11):5664-75. PMID: 26797128; PMCID: PMC4786706 [Available on 03/11/17].
  17. Kraus BJ, Sartoretto JL, Polak P, Hosooka T, Shiroto T, Eskurza I, Lee SA, Jiang H, Michel T, Kahn BB. Novel role for retinol-binding protein 4 in the regulation of blood pressure. FASEB J. 2015 Aug; 29(8):3133-40. PMID: 25911613; PMCID: PMC4511195.
  18. Dodd GT, Decherf S, Loh K, Simonds SE, Wiede F, Balland E, Merry TL, Münzberg H, Zhang ZY, Kahn BB, Neel BG, Bence KK, Andrews ZB, Cowley MA, Tiganis T. Leptin and insulin act on POMC neurons to promote the browning of white fat. Cell. 2015 Jan 15; 160(1-2):88-104. PMID: 25594176; PMCID: PMC4453004.
  19. Kraus D, Yang Q, Kahn BB. Lipid Extraction from Mouse Feces. Bio Protoc. 2015 Jan 05; 5(1). PMID: 27110587.
    View in: PubMed
  20. Zemany L, Bhanot S, Peroni OD, Murray SF, Moraes-Vieira PM, Castoldi A, Manchem P, Guo S, Monia BP, Kahn BB. Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice. Diabetes. 2015 May; 64(5):1603-14. PMID: 25524914; PMCID: PMC4407860 [Available on 05/01/16].
  21. Prothiwa M, Syed I, Huising MO, van der Meulen T, Donaldson CJ, Trauger SA, Kahn BB, Saghatelian A. Data-driven synthesis of proteolysis-resistant peptide hormones. J Am Chem Soc. 2014 Dec 24; 136(51):17710-3. PMID: 25496053.
    View in: PubMed
  22. Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 2014 Oct 09; 159(2):318-32. PMID: 25303528; PMCID: PMC4260972.
  23. Chiappini F, Catalano KJ, Lee J, Peroni OD, Lynch J, Dhaneshwar AS, Wellenstein K, Sontheimer A, Neel BG, Kahn BB. Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice. J Clin Invest. 2014 Sep; 124(9):3781-92. PMID: 25083988; PMCID: PMC4151212.
  24. Kahn B, Collazo J, Kyprianou N. Androgen receptor as a driver of therapeutic resistance in advanced prostate cancer. Int J Biol Sci. 2014; 10(6):588-95. PMID: 24948871; PMCID: PMC4062951.
  25. Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014 Apr 10; 508(7495):258-62. PMID: 24717514; PMCID: PMC4107212.
  26. Moraes-Vieira PM, Yore MM, Dwyer PM, Syed I, Aryal P, Kahn BB. RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metab. 2014 Mar 04; 19(3):512-26. PMID: 24606904; PMCID: PMC4078000.
  27. Zemany L, Kraus BJ, Norseen J, Saito T, Peroni OD, Johnson RL, Kahn BB. Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo. Mol Cell Biol. 2014 Mar; 34(6):1170-86. PMID: 24421389; PMCID: PMC3958040.
  28. Guzman J, Jauregui AN, Merscher-Gomez S, Maiguel D, Muresan C, Mitrofanova A, Diez-Sampedro A, Szust J, Yoo TH, Villarreal R, Pedigo C, Molano RD, Johnson K, Kahn B, Hartleben B, Huber TB, Saha J, Burke GW, Abel ED, Brosius FC, Fornoni A. Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy. Diabetes. 2014 Feb; 63(2):701-14. PMID: 24101677; PMCID: PMC3900538.
  29. Kahn BB, Minokoshi Y. Leptin, GABA, and glucose control. Cell Metab. 2013 Sep 03; 18(3):304-6. PMID: 24011066; PMCID: PMC4097301.
  30. Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integr Biol (Camb). 2013 Jul 24; 5(7):940-63. PMID: 23685806; PMCID: PMC3759823.
  31. Kurland IJ, Accili D, Burant C, Fischer SM, Kahn BB, Newgard CB, Ramagiri S, Ronnett GV, Ryals JA, Sanders M, Shambaugh J, Shockcor J, Gross SS. Application of combined omics platforms to accelerate biomedical discovery in diabesity. Ann N Y Acad Sci. 2013 May; 1287:1-16. PMID: 23659636; PMCID: PMC3709136.
  32. Sun Q, Kiernan UA, Shi L, Phillips DA, Kahn BB, Hu FB, Manson JE, Albert CM, Rexrode KM. Plasma retinol-binding protein 4 (RBP4) levels and risk of coronary heart disease: a prospective analysis among women in the nurses' health study. Circulation. 2013 May 14; 127(19):1938-47. PMID: 23584360; PMCID: PMC3741657.
  33. Wu N, Zheng B, Shaywitz A, Dagon Y, Tower C, Bellinger G, Shen CH, Wen J, Asara J, McGraw TE, Kahn BB, Cantley LC. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Mol Cell. 2013 Mar 28; 49(6):1167-75. PMID: 23453806; PMCID: PMC3615143.
  34. Lee KY, Russell SJ, Ussar S, Boucher J, Vernochet C, Mori MA, Smyth G, Rourk M, Cederquist C, Rosen ED, Kahn BB, Kahn CR. Lessons on conditional gene targeting in mouse adipose tissue. Diabetes. 2013 Mar; 62(3):864-74. PMID: 23321074; PMCID: PMC3581196.
  35. Hammarstedt A, Graham TE, Kahn BB. Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells. Diabetol Metab Syndr. 2012 Sep 19; 4(1):42. PMID: 22992414; PMCID: PMC3523053.
  36. Dagon Y, Hur E, Zheng B, Wellenstein K, Cantley LC, Kahn BB. p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake. Cell Metab. 2012 Jul 03; 16(1):104-12. PMID: 22727014; PMCID: PMC3407689.
  37. Kawashima J, Alquier T, Tsuji Y, Peroni OD, Kahn BB. Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia. PLoS One. 2012; 7(5):e36335. PMID: 22590531; PMCID: PMC3349669.
  38. Herman MA, Peroni OD, Villoria J, Schön MR, Abumrad NA, Blüher M, Klein S, Kahn BB. A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature. 2012 Apr 19; 484(7394):333-8. PMID: 22466288; PMCID: PMC3341994.
  39. Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, Kiernan UA, Phillips DA, Maruyama H, Kraus BJ, Usheva A, Davis RJ, Smith U, Kahn BB. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol. 2012 May; 32(10):2010-9. PMID: 22431523; PMCID: PMC3347417.
  40. Owen C, Czopek A, Agouni A, Grant L, Judson R, Lees EK, Mcilroy GD, Göransson O, Welch A, Bence KK, Kahn BB, Neel BG, Mody N, Delibegovic M. Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis. PLoS One. 2012; 7(2):e32700. PMID: 22389718; PMCID: PMC3289674.
  41. Myers MG, Heymsfield SB, Haft C, Kahn BB, Laughlin M, Leibel RL, Tschöp MH, Yanovski JA. Challenges and opportunities of defining clinical leptin resistance. Cell Metab. 2012 Feb 08; 15(2):150-6. PMID: 22326217; PMCID: PMC3281561.
  42. Yang Q, Eskurza I, Kiernan UA, Phillips DA, Blüher M, Graham TE, Kahn BB. Quantitative measurement of full-length and C-terminal proteolyzed RBP4 in serum of normal and insulin-resistant humans using a novel mass spectrometry immunoassay. Endocrinology. 2012 Mar; 153(3):1519-27. PMID: 22253430; PMCID: PMC3281532.
  43. Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E. A guide to analysis of mouse energy metabolism. Nat Methods. 2011 Dec 28; 9(1):57-63. PMID: 22205519; PMCID: PMC3654855.
  44. Loh K, Fukushima A, Zhang X, Galic S, Briggs D, Enriori PJ, Simonds S, Wiede F, Reichenbach A, Hauser C, Sims NA, Bence KK, Zhang S, Zhang ZY, Kahn BB, Neel BG, Andrews ZB, Cowley MA, Tiganis T. Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metab. 2011 Nov 02; 14(5):684-99. PMID: 22000926; PMCID: PMC3263335.
  45. Noriega LG, Feige JN, Canto C, Yamamoto H, Yu J, Herman MA, Mataki C, Kahn BB, Auwerx J. CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. EMBO Rep. 2011 Sep 30; 12(10):1069-76. PMID: 21836635; PMCID: PMC3185337.
  46. Pulinilkunnil T, He H, Kong D, Asakura K, Peroni OD, Lee A, Kahn BB. Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo. J Biol Chem. 2011 Mar 18; 286(11):8798-809. PMID: 21209093; PMCID: PMC3059037.
  47. Kahn BB, McGraw TE. Rosiglitazone, PPAR?, and type 2 diabetes. N Engl J Med. 2010 Dec 30; 363(27):2667-9. PMID: 21190462; PMCID: PMC3733169.
  48. Matsuo K, Delibegovic M, Matsuo I, Nagata N, Liu S, Bettaieb A, Xi Y, Araki K, Yang W, Kahn BB, Neel BG, Haj FG. Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2. J Biol Chem. 2010 Dec 17; 285(51):39750-8. PMID: 20841350; PMCID: PMC3000956.
  49. Yang Z, Kahn BB, Shi H, Xue BZ. Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J Biol Chem. 2010 Jun 18; 285(25):19051-9. PMID: 20421294; PMCID: PMC2885183.
  50. Kraus D, Herman MA, Kahn BB. Leveraging leptin for type I diabetes? Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):4793-4. PMID: 20212134; PMCID: PMC2841872.
  51. Herman MA, She P, Peroni OD, Lynch CJ, Kahn BB. Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. J Biol Chem. 2010 Apr 09; 285(15):11348-56. PMID: 20093359; PMCID: PMC2857013.
  52. Jourdan M, Jaleel A, Karakelides H, Ford GC, Kahn BB, Nair KS. Impact of type 1 diabetes and insulin treatment on plasma levels and fractional synthesis rate of retinol-binding protein 4. J Clin Endocrinol Metab. 2009 Dec; 94(12):5125-30. PMID: 19850685; PMCID: PMC2795661.
  53. Preitner F, Mody N, Graham TE, Peroni OD, Kahn BB. Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis. Am J Physiol Endocrinol Metab. 2009 Dec; 297(6):E1420-9. PMID: 19826103; PMCID: PMC2793052.
  54. Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK. Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology. 2009 Nov; 150(11):4874-82. PMID: 19819947; PMCID: PMC2775989.
  55. Stuck BJ, Kahn BB. Retinol-binding protein 4 (RBP4): a biomarker for subclinical atherosclerosis? Am J Hypertens. 2009 Sep; 22(9):948-9. PMID: 19701163.
    View in: PubMed
  56. Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med. 2009 Aug; 15(8):940-5. PMID: 19633655; PMCID: PMC2736875.
  57. Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, Kahn BB. Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues. Mol Cell Biol. 2009 Aug; 29(16):4563-73. PMID: 19528236; PMCID: PMC2725736.
  58. Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong EG, Cho YR, Kim JK, Kahn BB, Neel BG, Bence KK. Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress. Diabetes. 2009 Mar; 58(3):590-9. PMID: 19074988; PMCID: PMC2646057.
  59. Goodman E, Graham TE, Dolan LM, Daniels SR, Goodman ER, Kahn BB. The relationship of retinol binding protein 4 to changes in insulin resistance and cardiometabolic risk in overweight black adolescents. J Pediatr. 2009 Jan; 154(1):67-73.e1. PMID: 18783798; PMCID: PMC2770185.
  60. Enjyoji K, Kotani K, Thukral C, Blumel B, Sun X, Wu Y, Imai M, Friedman D, Csizmadia E, Bleibel W, Kahn BB, Robson SC. Deletion of cd39/entpd1 results in hepatic insulin resistance. Diabetes. 2008 Sep; 57(9):2311-20. PMID: 18567823; PMCID: PMC2518482.
  61. Krzyzanowska K, Zemany L, Krugluger W, Schernthaner GH, Mittermayer F, Schnack C, Rahman R, Brix J, Kahn BB, Schernthaner G. Serum concentrations of retinol-binding protein 4 in women with and without gestational diabetes. Diabetologia. 2008 Jul; 51(7):1115-22. PMID: 18437353; PMCID: PMC2676863.
  62. Hammarstedt A, Pihlajamäki J, Graham TE, Kainulainen S, Kahn BB, Laakso M, Smith U. High circulating levels of RBP4 and mRNA levels of aP2, PGC-1alpha and UCP-2 predict improvement in insulin sensitivity following pioglitazone treatment of drug-naïve type 2 diabetic subjects. J Intern Med. 2008 Apr; 263(4):440-9. PMID: 18324929; PMCID: PMC2676866.
  63. Mody N, Graham TE, Tsuji Y, Yang Q, Kahn BB. Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice. Am J Physiol Endocrinol Metab. 2008 Apr; 294(4):E785-93. PMID: 18285525; PMCID: PMC2711779.
  64. Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem. 2008 May 23; 283(21):14230-41. PMID: 18281274; PMCID: PMC2386946.
  65. Van Dyck F, Scroyen I, Declercq J, Sciot R, Kahn B, Lijnen R, Van de Ven WJ. aP2-Cre-mediated expression activation of an oncogenic PLAG1 transgene results in cavernous angiomatosis in mice. Int J Oncol. 2008 Jan; 32(1):33-40. PMID: 18097540.
    View in: PubMed
  66. Graham TE, Kahn BB. Tissue-specific alterations of glucose transport and molecular mechanisms of intertissue communication in obesity and type 2 diabetes. Horm Metab Res. 2007 Oct; 39(10):717-21. PMID: 17952832.
    View in: PubMed
  67. Kovacs P, Geyer M, Berndt J, Klöting N, Graham TE, Böttcher Y, Enigk B, Tönjes A, Schleinitz D, Schön MR, Kahn BB, Blüher M, Stumvoll M. Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression. Diabetes. 2007 Dec; 56(12):3095-100. PMID: 17728376.
    View in: PubMed
  68. Delibegovic M, Bence KK, Mody N, Hong EG, Ko HJ, Kim JK, Kahn BB, Neel BG. Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B. Mol Cell Biol. 2007 Nov; 27(21):7727-34. PMID: 17724080; PMCID: PMC2169063.
  69. Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, Shi GP. Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol. 2007 Aug; 9(8):970-7. PMID: 17643114.
    View in: PubMed
  70. Petersen KF, Dufour S, Savage DB, Bilz S, Solomon G, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Papademetris X, Rothman DL, Shulman GI. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31):12587-94. PMID: 17640906; PMCID: PMC1924794.
  71. Yan QW, Yang Q, Mody N, Graham TE, Hsu CH, Xu Z, Houstis NE, Kahn BB, Rosen ED. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes. 2007 Oct; 56(10):2533-40. PMID: 17639021.
    View in: PubMed
  72. Klöting N, Graham TE, Berndt J, Kralisch S, Kovacs P, Wason CJ, Fasshauer M, Schön MR, Stumvoll M, Blüher M, Kahn BB. Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab. 2007 Jul; 6(1):79-87. PMID: 17618858.
    View in: PubMed
  73. Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. J Biol Chem. 2007 Aug 17; 282(33):23829-40. PMID: 17545163.
    View in: PubMed
  74. Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kim JK, Peroni OD, Kahn BB, Jain MK. Regulation of gluconeogenesis by Krüppel-like factor 15. Cell Metab. 2007 Apr; 5(4):305-12. PMID: 17403374; PMCID: PMC1892530.
  75. Balagopal P, Graham TE, Kahn BB, Altomare A, Funanage V, George D. Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation. J Clin Endocrinol Metab. 2007 May; 92(5):1971-4. PMID: 17341558.
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  76. Kennedy AR, Pissios P, Otu H, Roberson R, Xue B, Asakura K, Furukawa N, Marino FE, Liu FF, Kahn BB, Libermann TA, Maratos-Flier E. A high-fat, ketogenic diet induces a unique metabolic state in mice. Am J Physiol Endocrinol Metab. 2007 Jun; 292(6):E1724-39. PMID: 17299079.
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  77. Graham TE, Wason CJ, Blüher M, Kahn BB. Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects. Diabetologia. 2007 Apr; 50(4):814-23. PMID: 17294166.
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  78. Alquier T, Kawashima J, Tsuji Y, Kahn BB. Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia. Endocrinology. 2007 Mar; 148(3):1367-75. PMID: 17185376.
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  79. Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med. 2006 Aug; 12(8):917-24. PMID: 16845389.
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  80. Herman MA, Kahn BB. Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest. 2006 Jul; 116(7):1767-75. PMID: 16823474; PMCID: PMC1483149.
  81. Graham TE, Yang Q, Blüher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson PA, Smith U, Kahn BB. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med. 2006 Jun 15; 354(24):2552-63. PMID: 16775236.
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  82. Kahn BB, Myers MG. mTOR tells the brain that the body is hungry. Nat Med. 2006 Jun; 12(6):615-7. PMID: 16761005.
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  83. Xue B, Kahn BB. AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol. 2006 Jul 01; 574(Pt 1):73-83. PMID: 16709629; PMCID: PMC1817809.
  84. Martin TL, Alquier T, Asakura K, Furukawa N, Preitner F, Kahn BB. Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. J Biol Chem. 2006 Jul 14; 281(28):18933-41. PMID: 16687413.
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  85. Kim YB, Peroni OD, Aschenbach WG, Minokoshi Y, Kotani K, Zisman A, Kahn CR, Goodyear LJ, Kahn BB. Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism. Mol Cell Biol. 2005 Nov; 25(21):9713-23. PMID: 16227617; PMCID: PMC1265843.
  86. Furukawa N, Ongusaha P, Jahng WJ, Araki K, Choi CS, Kim HJ, Lee YH, Kaibuchi K, Kahn BB, Masuzaki H, Kim JK, Lee SW, Kim YB. Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab. 2005 Aug; 2(2):119-29. PMID: 16098829.
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  87. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005 Jul 21; 436(7049):356-62. PMID: 16034410.
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  88. Carvalho E, Kotani K, Peroni OD, Kahn BB. Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle. Am J Physiol Endocrinol Metab. 2005 Oct; 289(4):E551-61. PMID: 15928024.
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  89. Jones JR, Barrick C, Kim KA, Lindner J, Blondeau B, Fujimoto Y, Shiota M, Kesterson RA, Kahn BB, Magnuson MA. Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A. 2005 Apr 26; 102(17):6207-12. PMID: 15833818; PMCID: PMC556131.
  90. Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005 Mar; 25(6):2498-510. PMID: 15743841; PMCID: PMC1061603.
  91. Haj FG, Zabolotny JM, Kim YB, Kahn BB, Neel BG. Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice. J Biol Chem. 2005 Apr 15; 280(15):15038-46. PMID: 15699041.
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  92. Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab. 2005 Feb; 1(2):107-19. PMID: 16054052.
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  93. Chimento GF, Pavone V, Sharrock N, Kahn B, Cahill J, Sculco TP. Minimally invasive total hip arthroplasty: a prospective randomized study. J Arthroplasty. 2005 Feb; 20(2):139-44. PMID: 15902851.
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  94. Galic S, Hauser C, Kahn BB, Haj FG, Neel BG, Tonks NK, Tiganis T. Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP. Mol Cell Biol. 2005 Jan; 25(2):819-29. PMID: 15632081; PMCID: PMC543412.
  95. Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 2005 Jan; 1(1):15-25. PMID: 16054041.
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  96. Collins S, Ahima RS, and Kahn BB. Biology of adipose tissue. In Joslin’s Diabetes Mellitus. CR Kahn, GC Weir, GL King, AC Moses, RJ Smith, AM Jacobson eds. 2005; 205-226.
  97. Corbould A, Kim YB, Youngren JF, Pender C, Kahn BB, Lee A, Dunaif A. Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling. Am J Physiol Endocrinol Metab. 2005 May; 288(5):E1047-54. PMID: 15613682.
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  98. Chan JL, Moschos SJ, Bullen J, Heist K, Li X, Kim YB, Kahn BB, Mantzoros CS. Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with relative leptin deficiency. J Clin Endocrinol Metab. 2005 Mar; 90(3):1625-31. PMID: 15613409.
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  99. Kotani K, Peroni OD, Minokoshi Y, Boss O, Kahn BB. GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization. J Clin Invest. 2004 Dec; 114(11):1666-75. PMID: 15578099; PMCID: PMC529279.
  100. Morroni M, Giordano A, Zingaretti MC, Boiani R, De Matteis R, Kahn BB, Nisoli E, Tonello C, Pisoschi C, Luchetti MM, Marelli M, Cinti S. Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland. Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16801-6. PMID: 15556998; PMCID: PMC534744.
  101. Patti ME, Kahn BB. Nutrient sensor links obesity with diabetes risk. Nat Med. 2004 Oct; 10(10):1049-50. PMID: 15459705.
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  102. Alquier T, Kahn BB. Peripheral signals set the tone for central regulation of metabolism. Endocrinology. 2004 Sep; 145(9):4022-4. PMID: 15321948.
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  103. Su EP, Kahn B, Figgie MP. Total ankle replacement in patients with rheumatoid arthritis. Clin Orthop Relat Res. 2004 Jul; (424):32-8. PMID: 15241141.
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  104. Lamia KA, Peroni OD, Kim YB, Rameh LE, Kahn BB, Cantley LC. Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Mol Cell Biol. 2004 Jun; 24(11):5080-7. PMID: 15143198; PMCID: PMC416424.
  105. Martin T, Alquier T, Kahn BB. Diet-induced obesity (DIO) causes resistance to leptin action on AMP-activated protein kinase (AMPK) in skeletal muscle. Presented at the American Diabetes Association Annual Scientific Session. Diabetes. 2004; 53(suppl 2):A413-A414.
  106. Minokoshi Y, Alquier T, Furukawa N, Kim Y-B, Lee A, Xue B, Mu J, Foufelle F, Ferre P, Birnbaum MJ, Stuck B, Kahn BB. Hypothalamic AMP kinase (AMPK) regulates food intake, body weight and expression of orexigenic neuropeptides. Presented at the American Diabetes Association Annual Scientific Sessions. Diabetes. 2004; 53(suppl 2):A74.
  107. Blüher M, Patti ME, Gesta S, Kahn BB, Kahn CR. Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression. J Biol Chem. 2004 Jul 23; 279(30):31891-901. PMID: 15131119.
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  108. Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferré P, Birnbaum MJ, Stuck BJ, Kahn BB. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature. 2004 Apr 01; 428(6982):569-74. PMID: 15058305.
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  109. Zabolotny JM, Haj FG, Kim YB, Kim HJ, Shulman GI, Kim JK, Neel BG, Kahn BB. Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action. J Biol Chem. 2004 Jun 04; 279(23):24844-51. PMID: 15031294.
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  110. Carvalho E, Schellhorn SE, Zabolotny JM, Martin S, Tozzo E, Peroni OD, Houseknecht KL, Mundt A, James DE, Kahn BB. GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase. J Biol Chem. 2004 May 14; 279(20):21598-605. PMID: 14985357.
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  111. Bjørbaek C, Kahn BB. Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res. 2004; 59:305-31. PMID: 14749508.
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  112. Abel ED, Shepherd PR, Kahn BB. Glucose transporters and pathophysiologic states. In Diabetes Mellitus: A Fundamental and Clinical Text. DR LeRoith, JM Olefsky and SI Taylor eds. 2004; 917-938.
  113. Kushner JA, Haj FG, Klaman LD, Dow MA, Kahn BB, Neel BG, White MF. Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. Diabetes. 2004 Jan; 53(1):61-6. PMID: 14693698.
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  114. Ganz PA, Greendale GA, Petersen L, Kahn B, Bower JE. Breast cancer in younger women: reproductive and late health effects of treatment. J Clin Oncol. 2003 Nov 15; 21(22):4184-93. PMID: 14615446.
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  115. Kim YB, Kotani K, Ciaraldi TP, Henry RR, Kahn BB. Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction. Diabetes. 2003 Aug; 52(8):1935-42. PMID: 12882908.
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  116. Minokoshi Y, Kahn CR, Kahn BB. Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis. J Biol Chem. 2003 Sep 05; 278(36):33609-12. PMID: 12788932.
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  117. Kim Y-B, Carvalho E, Kotani K, Avilucea P, Peroni O, Kahn BB. Adipose-specific overexpression of Glut4 selectively enhances insulin action on Akt and MAPK. Presented at the American Diabetes Association Annual Scientific Sessions. Diabetes. 2003; 52(suppl 1):A281.
  118. Minokoshi Y, Kim Y-B, Stuck B, Lee A, Foufelle F, Mu J, Ferre P, Birnbaum M, Kahn BB. Regulatory role of glucose and melancortin-4 receptor in AMP-activity protein kinase activity in the hypothalamus: association with feeding behavior. Presented at the American Diabetes Association Scientific Sessions. Diabetes. 2003; 52(suppl 1):A348.
  119. Zabolotny J, Kim K, Kim Y-B, Haj F, Shulman G, Neel B, Kahn BB. Impairments in insulin-stimulated muscle glucose uptake and whole-body glucose homeostasis caused by muscle–specific overexpression of LAR or PTP1B are not additive. Presented at the American Diabetes Association Scientific Sessions. Diabetes. 2003; 52(suppl 1):A315.
  120. Carvalho E, Kotani K, Peroni O, Kahn BB. Adipose-specific overexpression of Glut4 restores insulin sensitivity in mice with muscle-specific knockout of Glut4 without restoring glucose transporters in muscle. Presented at the American Diabetes Association Annual Scientific Sessions. Diabetes. 2003; 52(suppl 1):A313.
  121. Burcelin R, Crivelli V, Perrin C, Da Costa A, Mu J, Kahn BB, Birnbaum MJ, Kahn CR, Vollenweider P, Thorens B. GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization. J Clin Invest. 2003 May; 111(10):1555-62. PMID: 12750405; PMCID: PMC155044.
  122. Carr DL, Laharrague F, Kahn B, Pressley TA, Carr JA. Molecular characterization of a putative sodium/iodide symporter in the South African clawed frog, Xenopus laevis. Ann N Y Acad Sci. 2003 Apr; 986:711-2. PMID: 12763923.
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  123. Minokoshi Y, Kahn BB. Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle. Biochem Soc Trans. 2003 Feb; 31(Pt 1):196-201. PMID: 12546684.
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  124. Blüher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science. 2003 Jan 24; 299(5606):572-4. PMID: 12543978.
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  125. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 2002 Nov; 8(11):1288-95. PMID: 12368907.
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  126. Choi CS, Kim YB, Lee FN, Zabolotny JM, Kahn BB, Youn JH. Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling. Am J Physiol Endocrinol Metab. 2002 Aug; 283(2):E233-40. PMID: 12110527.
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  127. Kim YB, Shulman GI, Kahn BB. Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3. J Biol Chem. 2002 Sep 06; 277(36):32915-22. PMID: 12095990.
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  128. Blüher M, Michael MD, Peroni OD, Ueki K, Carter N, Kahn BB, Kahn CR. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell. 2002 Jul; 3(1):25-38. PMID: 12110165.
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  129. Carvalho E, Peroni OD, Kahn BB. Overexpression of Glut4 in fat “rescues” glucose intolerance in muscle-specific Glut4 knockout mice. Presented at the American Diabetes Association Annual Scientific Sessions. Diabetes. 2002; 51(suppl 2):A326.
  130. Kim Y-B, Peroni OD, Minokoshi Y, Achenbach WG, Zisman A, Goodyear LJ, Kahn BB. Paradoxically increased glycogen content in muscle-Glut4 knockout mice may be due to increased levels of glycogen-targeting subunits. Presented at the American Diabetes Association Annual Scientific Sessions. Diabetes. 2002; 51(suppl 2):A316.
  131. Minokoshi Y, Kim Y-B, Kahn BB. Role of the AMP-activated protein kinase as an energy sensor in the hypothalamus. Presented at the American Diabetes Association Annual Scientific Sessions. Diabetes. 2002; 51(suppl 2):A41.
  132. Minokoshi Y, Kim Y-B, Kahn BB. Leptin stimulates fatty acid oxidation directly in white adipose tissue through activation of AMP-activated protein kinase. Presented at the American Diabetes Association Annual Scientific Sessions. Diabetes. 2002; 51(suppl 2):A336.
  133. Kotani K, Peroni OD, Minokoshi Y, Kim Y-B, Kahn BB. Knockout of GLUT4 simultaneously from both muscle and fat causes hyperglycemia and hyperinsulinemia. Presented at the American Diabetes Association Annual Scientific Sessions. Diabetes. 2002; 51(suppl 2):A354.
  134. Jones JR, Amelse L, Barrick CJ, Blondeau B, Shelton KD, Kahn BB, Magnuson MA. Deletion of PPARã in adipose tissues of mice leads to impaired lipid deposition. Presented at the American Diabetes Association Annual Scientific Sessions. Diabetes. 2002; 51(suppl 2):A15.
  135. Kim Y-B, Peroni OD, Minokoshi Y, Achenbach WG, Zisman A, Goodyear LJ, Kahn . Paradoxically increased glycogen content in muscle-Glut4 knockout mice may be due to increased levels of glycogen-targeting subunits. Presented at the American Diabetes Association Annual Scientific Sessions. Diabetes. 2002; 51(suppl 2):A41.
  136. Zabolotny JM, Bence-Hanulec KK, Stricker-Krongrad A, Haj F, Wang Y, Minokoshi Y, Kim YB, Elmquist JK, Tartaglia LA, Kahn BB, Neel BG. PTP1B regulates leptin signal transduction in vivo. Dev Cell. 2002 Apr; 2(4):489-95. PMID: 11970898.
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  137. Kim YB, Ciaraldi TP, Kong A, Kim D, Chu N, Mohideen P, Mudaliar S, Henry RR, Kahn BB. Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects. Diabetes. 2002 Feb; 51(2):443-8. PMID: 11812753.
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  138. Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Müller C, Carling D, Kahn BB. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature. 2002 Jan 17; 415(6869):339-43. PMID: 11797013.
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  139. Carvalho E, Peroni OD, Kahn BB. Overexpression of Glut4 in adipose tissue “rescues” insulin resistance and glucose intolerance in muscle-specific Glut4 knockout mice. Presented at the Keystone conference on Diabetes Mellitus: Molecular Mechanisms, Genetics and New Therapies. Keystone, CO. 2002.
  140. Tanner CJ, Koves TR, Cortright RL, Pories WJ, Kim YB, Kahn BB, Dohm GL, Houmard JA. Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men. Am J Physiol Endocrinol Metab. 2002 Jan; 282(1):E147-53. PMID: 11739095.
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  141. Miric A, Lim M, Kahn B, Rozenthal T, Bombick D, Sculco TP. Perioperative morbidity following total knee arthroplasty among obese patients. J Knee Surg. 2002; 15(2):77-83. PMID: 12013077.
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  142. Larkin LM, Reynolds TH, Supiano MA, Kahn BB, Halter JB. Effect of aging and obesity on insulin responsiveness and glut-4 glucose transporter content in skeletal muscle of Fischer 344 x Brown Norway rats. J Gerontol A Biol Sci Med Sci. 2001 Nov; 56(11):B486-92. PMID: 11682570; PMCID: PMC2714732.
  143. Kim JK, Zisman A, Fillmore JJ, Peroni OD, Kotani K, Perret P, Zong H, Dong J, Kahn CR, Kahn BB, Shulman GI. Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. J Clin Invest. 2001 Jul; 108(1):153-60. PMID: 11435467; PMCID: PMC353719.
  144. Peroni OD, Boss OD, Kim Y-B, Kahn BB. Glucose transport in adipose tissue is essential for the acute effect of â3 adrenergic agonists on glucose homeostasis. Presented at the American Diabetes Association Annual Scientific Sessions. Diabetes. 2001; 50(suppl 2):A308.
  145. Zabolotny JM, Kim YB, Peroni OD, Kim JK, Pani MA, Boss O, Klaman LD, Kamatkar S, Shulman GI, Kahn BB, Neel BG. Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance. Proc Natl Acad Sci U S A. 2001 Apr 24; 98(9):5187-92. PMID: 11309481; PMCID: PMC33185.
  146. Dickson LM, Lingohr MK, McCuaig J, Hugl SR, Snow L, Kahn BB, Myers MG, Rhodes CJ. Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1). J Biol Chem. 2001 Jun 15; 276(24):21110-20. PMID: 11274216.
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  147. Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature. 2001 Feb 08; 409(6821):729-33. PMID: 11217863.
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  148. Huppertz C, Fischer BM, Kim YB, Kotani K, Vidal-Puig A, Slieker LJ, Sloop KW, Lowell BB, Kahn BB. Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism. J Biol Chem. 2001 Apr 20; 276(16):12520-9. PMID: 11278970.
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  149. Kim Y-B, Peroni OD, Zisman A, Kim JK, Kahn BB. Muscle-specific knock out of GLUT4 down-regulates signaling. Presented at the American Diabetes Association Annual Scientific Sessions. Diabetes. 2001; 50(auppl 2):A274.
  150. Miric A, Kahn B, Waldman B, Sculco TP. Characteristics and natural history of transient postoperative pseudosubluxation after total hip arthroplasty. J Arthroplasty. 2000 Sep; 15(6):736-43. PMID: 11021449.
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  151. Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol. 2000 Aug; 20(15):5479-89. PMID: 10891488; PMCID: PMC85999.
  152. Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, Kahn BB. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med. 2000 Aug; 6(8):924-8. PMID: 10932232.
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  153. Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest. 2000 Aug; 106(4):473-81. PMID: 10953022; PMCID: PMC380258.
  154. Ganz PA, Greendale GA, Petersen L, Zibecchi L, Kahn B, Belin TR. Managing menopausal symptoms in breast cancer survivors: results of a randomized controlled trial. J Natl Cancer Inst. 2000 Jul 05; 92(13):1054-64. PMID: 10880548.
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  155. Kim YB, Uotani S, Pierroz DD, Flier JS, Kahn BB. In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology. 2000 Jul; 141(7):2328-39. PMID: 10875232.
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  156. Venable CL, Frevert EU, Kim YB, Fischer BM, Kamatkar S, Neel BG, Kahn BB. Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation. J Biol Chem. 2000 Jun 16; 275(24):18318-26. PMID: 10751417.
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  157. Kim JK, Michael MD, Previs SF, Peroni OD, Mauvais-Jarvis F, Neschen S, Kahn BB, Kahn CR, Shulman GI. Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. J Clin Invest. 2000 Jun; 105(12):1791-7. PMID: 10862794; PMCID: PMC378504.
  158. Peroni OD, Zisman A, Wojtaszewski JFP, Hirshman MF, Abel ED, Goodyear LJ, Kahn BB. Exercise capacity is impaired in mice with muscle-specific GLUT4 knock out but is normal with cardiac-specific GLUT4 knock out. Presented at the American Diabetes Association Annual Scientific Sessions. Diabetes. 2000; 49(suppl 1):A242.
  159. Permana PA, Kahn BB, Huppertz C, Mott DM. Functional analyses of amino acid substitutions Arg883Ser and Asp905Tyr of protein phosphatase-1 G-subunit. Mol Genet Metab. 2000 Jun; 70(2):151-8. PMID: 10873397.
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  160. Rasmussen SK, Hansen L, Frevert EU, Cohen PT, Kahn BB, Pedersen O. Adenovirus-mediated expression of a naturally occurring Asp905Tyr variant of the glycogen-associated regulatory subunit of protein phosphatase-1 in L6 myotubes. Diabetologia. 2000 Jun; 43(6):718-22. PMID: 10907117.
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  161. Kim YB, Peroni OD, Franke TF, Kahn BB. Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats. Diabetes. 2000 May; 49(5):847-56. PMID: 10905496.
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  162. Xie Z, Li H, Liu L, Kahn BB, Najjar SM, Shah W. Metabolic regulation of Na(+)/P(i)-cotransporter-1 gene expression in H4IIE cells. Am J Physiol Endocrinol Metab. 2000 Apr; 278(4):E648-55. PMID: 10751198.
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  163. Shepherd PR, Abel ED, Kahn BB. Glucose transporters and pathophysiologic states. In Diabetes Mellitus: A Fundamental and Clinical Text. DR LeRoith, JM Olefsky and SI Taylor eds. 2000; 627-641.
  164. Abel ED, Kaulbach HC, Tian R, Hopkins JC, Duffy J, Doetschman T, Minnemann T, Boers ME, Hadro E, Oberste-Berghaus C, Quist W, Lowell BB, Ingwall JS, Kahn BB. Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J Clin Invest. 1999 Dec; 104(12):1703-14. PMID: 10606624; PMCID: PMC409881.
  165. Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest. 1999 Sep; 104(6):733-41. PMID: 10491408; PMCID: PMC408433.
  166. Greendale GA, Zibecchi L, Petersen L, Ouslander JG, Kahn B, Ganz PA. Development and validation of a physical examination scale to assess vaginal atrophy and inflammation. Climacteric. 1999 Sep; 2(3):197-204. PMID: 11910597.
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  167. Ganz PA, Greendale GA, Kahn B, O'Leary JF, Desmond KA. Are older breast carcinoma survivors willing to take hormone replacement therapy? Cancer. 1999 Sep 01; 86(5):814-20. PMID: 10463980.
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  168. Shepherd PR, Kahn BB. Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus. N Engl J Med. 1999 Jul 22; 341(4):248-57. PMID: 10413738.
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  169. Smith J, Burks DJ, Peroni O, Withers DJ, Altamuro S, Myers MG, Lanner C, Depaoli Roach A, Kahn BB, White MF. Adipocyte function in IRS2-/- mice. Presented at the American Diabetes Association Annual Scientific Sessions. Diabetes. 1999; 49(suppl 1):A12.
  170. Oh ES, Gu H, Saxton TM, Timms JF, Hausdorff S, Frevert EU, Kahn BB, Pawson T, Neel BG, Thomas SM. Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2. Mol Cell Biol. 1999 Apr; 19(4):3205-15. PMID: 10082587; PMCID: PMC84114.
  171. Law BK, Nørgaard P, Gnudi L, Kahn BB, Poulson HS, Moses HL. Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway. J Biol Chem. 1999 Feb 19; 274(8):4743-8. PMID: 9988711.
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  172. Kim YB, Zhu JS, Zierath JR, Shen HQ, Baron AD, Kahn BB. Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle. Diabetes. 1999 Feb; 48(2):310-20. PMID: 10334307.
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  173. Kahn BB. Transgenic models of insulin resistance: a focus on the manipulation of the distal glucose transport step. Practical Diabetes International. 1999; (16):S22-S23.
  174. Kahn BB, Rossetti L. Type 2 diabetes--who is conducting the orchestra? Nat Genet. 1998 Nov; 20(3):223-5. PMID: 9806535.
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  175. Frevert EU, Bjørbaek C, Venable CL, Keller SR, Kahn BB. Targeting of constitutively active phosphoinositide 3-kinase to GLUT4-containing vesicles in 3T3-L1 adipocytes. J Biol Chem. 1998 Sep 25; 273(39):25480-7. PMID: 9738018.
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  176. Su J, Chai X, Kahn B, Napoli JL. cDNA cloning, tissue distribution, and substrate characteristics of a cis-Retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme. J Biol Chem. 1998 Jul 10; 273(28):17910-6. PMID: 9651397.
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  177. Kometiani P, Li J, Gnudi L, Kahn BB, Askari A, Xie Z. Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases. J Biol Chem. 1998 Jun 12; 273(24):15249-56. PMID: 9614140.
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  178. Kahn BB. Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance. Cell. 1998 Mar 06; 92(5):593-6. PMID: 9506512.
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  179. Sutherland C, Waltner-Law M, Gnudi L, Kahn BB, Granner DK. Activation of the ras mitogen-activated protein kinase-ribosomal protein kinase pathway is not required for the repression of phosphoenolpyruvate carboxykinase gene transcription by insulin. J Biol Chem. 1998 Feb 06; 273(6):3198-204. PMID: 9452431.
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  180. Gnudi L, Kahn BB. Use of recombinant adenovirus-mediated gene transfer to study insulin action in 3T3L1 adipocytes. Frontiers in Diabetes. Molecular and Cell Biology of Type 2 Diabetes and Its Complications. 1998; (14):154-156.
  181. Goodyear LJ, Kahn BB. Exercise, glucose transport, and insulin sensitivity. Annu Rev Med. 1998; 49:235-61. PMID: 9509261.
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  182. Zierath JR, Frevert EU, Ryder JW, Berggren PO, Kahn BB. Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes. Diabetes. 1998 Jan; 47(1):1-4. PMID: 9421367.
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  183. Tozzo E, Gnudi L, Kahn BB. Amelioration of insulin resistance in streptozotocin diabetic mice by transgenic overexpression of GLUT4 driven by an adipose-specific promoter. Endocrinology. 1997 Apr; 138(4):1604-11. PMID: 9075721.
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  184. Zierath JR, Houseknecht KL, Gnudi L, Kahn BB. High-fat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect. Diabetes. 1997 Feb; 46(2):215-23. PMID: 9000697.
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  185. Houseknecht KL, Kahn BB. Molecular mechanisms for insulin-stimulated glucose transport: Regulation of GLUT4 translocation. J Anim Sci. 1997; (75 (sup. 1)):32-45.
  186. Gnudi L, Frevert EU, Houseknecht KL, Erhardt P, Kahn BB. Adenovirus-mediated gene transfer of dominant negative ras(asn17) in 3T3L1 adipocytes does not alter insulin-stimulated P13-kinase activity or glucose transport. Mol Endocrinol. 1997 Jan; 11(1):67-76. PMID: 8994189.
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  187. Frevert EU, Kahn BB. Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes. Mol Cell Biol. 1997 Jan; 17(1):190-8. PMID: 8972199; PMCID: PMC231743.
  188. Magnan C, Gilbert M, Kahn BB. Chronic free fatty acid infusion in rats results in insulin resistance but no alteration in insulin-responsive glucose transporter levels in skeletal muscle. Lipids. 1996 Nov; 31(11):1141-9. PMID: 8934446.
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  189. Houseknecht KL, Mantzoros CS, Kuliawat R, Hadro E, Flier JS, Kahn BB. Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity. Diabetes. 1996 Nov; 45(11):1638-43. PMID: 8866573.
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  190. Kahn BB. Lilly lecture 1995. Glucose transport: pivotal step in insulin action. Diabetes. 1996 Nov; 45(11):1644-54. PMID: 8866574.
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  191. Frevert EU, Kahn BB. Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states. Biochem J. 1996 Jun 15; 316 ( Pt 3):865-71. PMID: 8670164; PMCID: PMC1217430.
  192. Houseknecht KL, Zhu AX, Gnudi L, Hamann A, Zierath JR, Tozzo E, Flier JS, Kahn BB. Overexpression of Ha-ras selectively in adipose tissue of transgenic mice. Evidence for enhanced sensitivity to insulin. J Biol Chem. 1996 May 10; 271(19):11347-55. PMID: 8626688.
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  193. Tozzo E, Kahn BB, Pilch PF, Kandror KV. Glut4 is targeted to specific vesicles in adipocytes of transgenic mice overexpressing Glut4 selectively in adipose tissue. J Biol Chem. 1996 May 03; 271(18):10490-4. PMID: 8631845.
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  194. Gnudi L, Jensen DR, Tozzo E, Eckel RH, Kahn BB. Adipose-specific overexpression of GLUT-4 in transgenic mice alters lipoprotein lipase activity. Am J Physiol. 1996 Apr; 270(4 Pt 2):R785-92. PMID: 8967408.
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  195. Gnudi L, Shepherd PR, Kahn BB. Over-expression of GLUT4 selectively in adipose tissue in transgenic mice: implications for nutrient partitioning. Proc Nutr Soc. 1996 Mar; 55(1B):191-9. PMID: 8832791.
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  196. Gabbay RA, Sutherland C, Gnudi L, Kahn BB, O'Brien RM, Granner DK, Flier JS. Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway. J Biol Chem. 1996 Jan 26; 271(4):1890-7. PMID: 8567635.
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  197. Ganz PA, Coscarelli A, Fred C, Kahn B, Polinsky ML, Petersen L. Breast cancer survivors: psychosocial concerns and quality of life. Breast Cancer Res Treat. 1996; 38(2):183-99. PMID: 8861837.
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  198. Zierath JR, Houseknecht KL, Kahn BB. Glucose transporters and diabetes. Seminars in Cell and Developmental Biology. 1996; 295-307.
  199. Abel ED, Shepherd PR, Kahn BB. Glucose transporters and pathophysiologic states. In Diabetes Mellitus: A Fundamental and Clinical Text. DR LeRoith, JM Olefsky and SI Taylor eds. 1996; 530-543.
  200. Gnudi L, Shepherd PR, Tozzo E, Kahn BB. Selective overexpression in adipose cells in transgenic mice of GLUT4: (The major insulin regulatable glucose transporter). In Molecular and Genetic Aspects of Obesity. 1996; 624-635.
  201. Susulic VS, Frederich RC, Lawitts J, Tozzo E, Kahn BB, Harper ME, Himms-Hagen J, Flier JS, Lowell BB. Targeted disruption of the beta 3-adrenergic receptor gene. J Biol Chem. 1995 Dec 08; 270(49):29483-92. PMID: 7493988.
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  202. Zierath JR, Nolte LA, Wahlström E, Galuska D, Shepherd PR, Kahn BB, Wallberg-Henriksson H. Carrier-mediated fructose uptake significantly contributes to carbohydrate metabolism in human skeletal muscle. Biochem J. 1995 Oct 15; 311 ( Pt 2):517-21. PMID: 7487889; PMCID: PMC1136029.
  203. Frederich RC, Löllmann B, Hamann A, Napolitano-Rosen A, Kahn BB, Lowell BB, Flier JS. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest. 1995 Sep; 96(3):1658-63. PMID: 7657836; PMCID: PMC185793.
  204. Tozzo E, Shepherd PR, Gnudi L, Kahn BB. Transgenic GLUT-4 overexpression in fat enhances glucose metabolism: preferential effect on fatty acid synthesis. Am J Physiol. 1995 May; 268(5 Pt 1):E956-64. PMID: 7762651.
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  205. Gnudi L, Tozzo E, Shepherd PR, Bliss JL, Kahn BB. High level overexpression of glucose transporter-4 driven by an adipose-specific promoter is maintained in transgenic mice on a high fat diet, but does not prevent impaired glucose tolerance. Endocrinology. 1995 Mar; 136(3):995-1002. PMID: 7867610.
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  206. Gnudi L, Kahn BB. Trasportatori di glucosio e diabete. In Giornale Italiano di Diabetologia. 1995; (15):131-139.
  207. Vestergaard H, Weinreb JE, Rosen AS, Bjørbaek C, Hansen L, Pedersen O, Kahn BB. Sulfonylurea therapy improves glucose disposal without changing skeletal muscle GLUT4 levels in noninsulin-dependent diabetes mellitus subjects: a longitudinal study. J Clin Endocrinol Metab. 1995 Jan; 80(1):270-5. PMID: 7829624.
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  208. Abel ED, Houseknecht KL, Kahn BB. Recent advances in understanding the molecular basis for insulin stimulated glucose transport. In Current Opinions in Endocrinology and Diabetes. 1995; (2):313-324.
  209. Haberkorn U, Morr I, Oberdorfer F, Bellemann ME, Blatter J, Altmann A, Kahn B, van Kaick G. Fluorodeoxyglucose uptake in vitro: aspects of method and effects of treatment with gemcitabine. J Nucl Med. 1994 Nov; 35(11):1842-50. PMID: 7965167.
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  210. Moran A, Pyzdrowski KL, Weinreb J, Kahn BB, Smith SA, Adams KS, Seaquist ER. Insulin sensitivity in cystic fibrosis. Diabetes. 1994 Aug; 43(8):1020-6. PMID: 8039595.
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  211. Kahn BB. Dietary regulation of glucose transporter gene expression: tissue specific effects in adipose cells and muscle. J Nutr. 1994 Aug; 124(8 Suppl):1289S-1295S. PMID: 8064377.
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  212. Rajan AS, Luo ZT, Kahn BB, Comstock JP, Cushman SW, Boyd AE. Do adipocytes contain high affinity sulfonylurea receptors. Endocrinology. 1994 Mar; 134(3):1581-8. PMID: 8119201.
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  213. Shepherd PR and Kahn BB. Expression of the GLUT4 glucose transporter in diabetes. In Molecular Biology of Diabetes. B Draznin and D LeRoith eds. 1994; 529-546.
  214. Andersen PH, Lund S, Schmitz O, Junker S, Kahn BB, Pedersen O. Increased insulin-stimulated glucose uptake in athletes: the importance of GLUT4 mRNA, GLUT4 protein and fibre type composition of skeletal muscle. Acta Physiol Scand. 1993 Dec; 149(4):393-404. PMID: 8128887.
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  215. Shepherd PR, Gnudi L, Tozzo E, Yang H, Leach F, Kahn BB. Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J Biol Chem. 1993 Oct 25; 268(30):22243-6. PMID: 8226728.
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  216. Andersen PH, Vestergaard H, Lund S, Vedel P, Junker S, Kahn BB, Pedersen O. The effect of intensive insulin therapy on the insulin-regulatable glucose transporter (GLUT4) expression in skeletal muscle in type 1 diabetes. Diabet Med. 1993 Oct; 10(8):699-706. PMID: 7505214.
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  217. Andersen PH, Lund S, Vestergaard H, Junker S, Kahn BB, Pedersen O. Expression of the major insulin regulatable glucose transporter (GLUT4) in skeletal muscle of noninsulin-dependent diabetic patients and healthy subjects before and after insulin infusion. J Clin Endocrinol Metab. 1993 Jul; 77(1):27-32. PMID: 8325952.
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  218. Flier JS, Moller DE, Moses AC, O'Rahilly S, Chaiken RL, Grigorescu F, Elahi D, Kahn BB, Weinreb JE, Eastman R. Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance. J Clin Endocrinol Metab. 1993 Jun; 76(6):1533-41. PMID: 8388881.
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  219. Hughes VA, Fiatarone MA, Fielding RA, Kahn BB, Ferrara CM, Shepherd P, Fisher EC, Wolfe RR, Elahi D, Evans WJ. Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. Am J Physiol. 1993 Jun; 264(6 Pt 1):E855-62. PMID: 8333511.
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  220. Kahn BB, Pedersen O. Suppression of GLUT4 expression in skeletal muscle of rats that are obese from high fat feeding but not from high carbohydrate feeding or genetic obesity. Endocrinology. 1993 Jan; 132(1):13-22. PMID: 8419118.
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  221. Elahi D, McAloon-Dyke M, Clark BA, Kahn BB, Weinreb JE, Minaker KL, Wong GA, Morse LA, Brown RS, Shapiro ME, et al. Sequential evaluation of islet cell responses to glucose in the transplanted pancreas in humans. Am J Surg. 1993 Jan; 165(1):15-22. PMID: 8418690.
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  222. Shepherd PR and Kahn BB. Cellular defects in glucose transport: lessons from animal models and implications for human insulin resistance. In Insulin Resistance DE Moller ed. 1993; 253-281.
  223. Schag CA, Ganz PA, Kahn B, Petersen L. Assessing the needs and quality of life of patients with HIV infection: development of the HIV Overview of Problems-Evaluation System (HOPES). Qual Life Res. 1992 Dec; 1(6):397-413. PMID: 1299472.
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  224. Shepherd PR, Gould GW, Colville CA, McCoid SC, Gibbs EM, Kahn BB. Distribution of GLUT3 glucose transporter protein in human tissues. Biochem Biophys Res Commun. 1992 Oct 15; 188(1):149-54. PMID: 1417839.
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  225. Shepherd PR, Gibbs EM, Wesslau C, Gould GW, Kahn BB. Human small intestine facilitative fructose/glucose transporter (GLUT5) is also present in insulin-responsive tissues and brain. Investigation of biochemical characteristics and translocation. Diabetes. 1992 Oct; 41(10):1360-5. PMID: 1397712.
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  226. Pedersen O, Kahn CR, Kahn BB. Divergent regulation of the Glut 1 and Glut 4 glucose transporters in isolated adipocytes from Zucker rats. J Clin Invest. 1992 Jun; 89(6):1964-73. PMID: 1534819; PMCID: PMC295898.
  227. Kahn BB, Pedersen O. Tissue-specific regulation of glucose transporters in different forms of obesity. Proc Soc Exp Biol Med. 1992 Jun; 200(2):214-7. PMID: 1579586.
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  228. Kahn BB, Rosen AS, Bak JF, Andersen PH, Damsbo P, Lund S, Pedersen O. Expression of GLUT1 and GLUT4 glucose transporters in skeletal muscle of humans with insulin-dependent diabetes mellitus: regulatory effects of metabolic factors. J Clin Endocrinol Metab. 1992 May; 74(5):1101-9. PMID: 1569156.
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  229. Kahn BB. Facilitative glucose transporters: regulatory mechanisms and dysregulation in diabetes. J Clin Invest. 1992 May; 89(5):1367-74. PMID: 1569179; PMCID: PMC443004.
  230. Gould GW, Brant AM, Kahn BB, Shepherd PR, McCoid SC, Gibbs EM. Expression of the brain-type glucose transporter is restricted to brain and neuronal cells in mice. Diabetologia. 1992 Apr; 35(4):304-9. PMID: 1516757.
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  231. Frederich RC, Kahn BB, Peach MJ, Flier JS. Tissue-specific nutritional regulation of angiotensinogen in adipose tissue. Hypertension. 1992 Apr; 19(4):339-44. PMID: 1555865.
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  232. Kahn BB. Regolazione dei trasportatori del glucosio negli stati di insulino resistenza. Il Diabete. 1992; 13-17.
  233. Alexander-Bridges M, Buggs C, Giere L, Denaro M, Kahn B, White M, Sukhatme V, Nasrin N. Models of insulin action on metabolic and growth response genes. Mol Cell Biochem. 1992 Feb 12; 109(2):99-105. PMID: 1625685.
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  234. Kahn BB. Alterations in glucose transporter expression and function in diabetes: mechanisms for insulin resistance. J Cell Biochem. 1992 Feb; 48(2):122-8. PMID: 1618926.
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  235. Tal M, Kahn BB, Lodish HF. Expression of the low Km GLUT-1 glucose transporter is turned on in perivenous hepatocytes of insulin-deficient diabetic rats. Endocrinology. 1991 Oct; 129(4):1933-41. PMID: 1915077.
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  236. Pedersen O, Kahn CR, Flier JS, Kahn BB. High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut 4) in fat cells of rats. Endocrinology. 1991 Aug; 129(2):771-7. PMID: 1855475.
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  237. Rudolph AS, Ratna BR, Kahn B. Self-assembling phospholipid filaments. Nature. 1991 Jul 04; 352(6330):52-5. PMID: 2062377.
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  238. Kahn BB, Rossetti L, Lodish HF, Charron MJ. Decreased in vivo glucose uptake but normal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats. J Clin Invest. 1991 Jun; 87(6):2197-206. PMID: 2040701; PMCID: PMC296980.
  239. Kahn BB, Shulman GI, DeFronzo RA, Cushman SW, Rossetti L. Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression. J Clin Invest. 1991 Feb; 87(2):561-70. PMID: 1991839; PMCID: PMC296344.
  240. Kahn BB. Role of glucose transporters in diabetes. In Diabetes 1991. H Rifkin, JA Colwell and SI Taylor eds. 1991; 429-433.
  241. Kahn BB, Pedersen O. Tissue specific regulation of glucose transporters in adipose cells and muscle of obese Zucker rats. In New Directions in Research and Clinical works for Obesity and Diabetes Mellitus. 1991; 225-227.
  242. Ploug T, Stallknecht BM, Pedersen O, Kahn BB, Ohkuwa T, Vinten J, Galbo H. Effect of endurance training on glucose transport capacity and glucose transporter expression in rat skeletal muscle. Am J Physiol. 1990 Dec; 259(6 Pt 1):E778-86. PMID: 2175551.
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  243. Pedersen O, Bak JF, Andersen PH, Lund S, Moller DE, Flier JS, Kahn BB. Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM. Diabetes. 1990 Jul; 39(7):865-70. PMID: 2354749.
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  244. Kahn BB, Flier JS. Regulation of glucose-transporter gene expression in vitro and in vivo. Diabetes Care. 1990 Jun; 13(6):548-64. PMID: 2192844.
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  245. Thorens B, Flier JS, Lodish HF, Kahn BB. Differential regulation of two glucose transporters in rat liver by fasting and refeeding and by diabetes and insulin treatment. Diabetes. 1990 Jun; 39(6):712-9. PMID: 2140804.
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  246. Charron MJ, Kahn BB. Divergent molecular mechanisms for insulin-resistant glucose transport in muscle and adipose cells in vivo. J Biol Chem. 1990 May 15; 265(14):7994-8000. PMID: 2335513.
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  247. Kahn BB, Charron MJ, Lodish HF, Cushman SW, Flier JS. Differential regulation of two glucose transporters in adipose cells from diabetic and insulin-treated diabetic rats. J Clin Invest. 1989 Aug; 84(2):404-11. PMID: 2668332; PMCID: PMC548897.
  248. Kahn BB. Glucose transporters in diabetes and related disorders. In Genes and Gene Products in the Development of Diabetes Mellitus. 1989; 299-312.
  249. Kahn BB and Cushman SW. Perturbed glucose transport in diabetes mellitus. In Non-Insulin-Dependent Diabetes Mellitus. 1989; 19-27.
  250. Kahn BB and Cushman SW. Regulation of glucose transport in diabetes. In Frontiers of Diabetes Research: Current Trends in Non-insulin-dependent Diabetes Mellitus. KGMM Alberti, RS Mazze, editors. 1989; 155-165.
  251. Kahn BB and Cushman SW. Cell biology of insulin action on glucose transport and its perturbation in diabetes mellitus. In Diabetes Mellitus: Pathophysiology and Therapy. W. Creutzfeldt and P. Lefebvre, editors. 1989; 94-106.
  252. Kahn BB, Cushman SW, Flier JS. Regulation of glucose transporter-specific mRNA levels in rat adipose cells with fasting and refeeding. Implications for in vivo control of glucose transporter number. J Clin Invest. 1989 Jan; 83(1):199-204. PMID: 2910908; PMCID: PMC303662.
  253. Alexander M, Denaro M, Galli R, Kahn B, Nasrin N. Tissue specific regulation of the glyceraldehyde-3-phosphate dehydrogenase gene by insulin correlates with the induction of an insulin-sensitive transcription factor during differentiation of 3T3 adipocytes. In Obesity: Towards a Molecular Approach, UCLA Symposia on Molecular and Cellular Biology. 1989; 247-261.
  254. Kahn BB, Simpson IA, Cushman SW. Divergent mechanisms for the insulin resistant and hyperresponsive glucose transport in adipose cells from fasted and refed rats. Alterations in both glucose transporter number and intrinsic activity. J Clin Invest. 1988 Aug; 82(2):691-9. PMID: 3403723; PMCID: PMC303565.
  255. Kahn BB, Weintraub BD, Csako G, Zweig MH. Factitious elevation of thyrotropin in a new ultrasensitive assay: implications for the use of monoclonal antibodies in "sandwich" immunoassay. J Clin Endocrinol Metab. 1988 Mar; 66(3):526-33. PMID: 3127416.
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  256. Zweig MH, Csako G, Benson CC, Weintraub BD, Kahn BB. Interference by anti-immunoglobulin G antibodies in immunoradiometric assays of thyrotropin involving mouse monoclonal antibodies. Clin Chem. 1987 Jun; 33(6):840-4. PMID: 3496176.
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  257. Kahn BB, Cushman SW. Mechanism for markedly hyperresponsive insulin-stimulated glucose transport activity in adipose cells from insulin-treated streptozotocin diabetic rats. Evidence for increased glucose transporter intrinsic activity. J Biol Chem. 1987 Apr 15; 262(11):5118-24. PMID: 3549715.
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  258. Kahn BB, Horton ES, Cushman SW. Mechanism for enhanced glucose transport response to insulin in adipose cells from chronically hyperinsulinemic rats. Increased translocation of glucose transporters from an enlarged intracellular pool. J Clin Invest. 1987 Mar; 79(3):853-8. PMID: 3029179; PMCID: PMC424219.
  259. Kahn BB, Cushman SW. Cell biology of insulin's stimulatory action on glucose transport and its perturbation in altered metabolic states. Ann N Y Acad Sci. 1986; 488:356-69. PMID: 3555256.
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  260. Kahn BB, Cushman SW. Subcellular translocation of glucose transporters: role in insulin action and its perturbation in altered metabolic states. Diabetes Metab Rev. 1985; 1(3):203-27. PMID: 3915254.
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