Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Judy Lieberman, M.D., Ph.D.

Title
Institution
Department
Address
Phone
Fax

Mentoring
completed student projects
Synthesis of a bifunctional chimera: Discriminate delivery of siRNA to CD4+ cells by fusion to RNA-based aptamers
Summer, 01/02/07 - 08/15/07
Understanding the role of tumor-derived extracellular vesicles in breast cancer metastasis
Summer, 06/05/15 - 08/28/15

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01CA240955 (LIEBERMAN, JUDY) Apr 3, 2020 - Mar 31, 2025
    NIH
    Gasdermin E and pyroptosis in cancer
    Role: Principal Investigator
  2. R21AI150671 (LIEBERMAN, JUDY) Mar 1, 2020 - Feb 28, 2022
    NIH
    Endogenous ligand of the NK activating receptor NKp46
    Role: Principal Investigator
  3. R01AI145862 (LIEBERMAN, JUDY) Jun 19, 2019 - May 31, 2024
    NIH
    Decidual NK response to infection
    Role: Principal Investigator
  4. R21AI131632 (GAZZINELLI, RICARDO) Jan 9, 2018 - Dec 31, 2019
    NIH
    Killing of P. vivax infected reticulocytes by cytotoxic T cells
    Role: Co-Principal Investigator
  5. R01AI124491 (WU, HAO) Jul 1, 2016 - Jun 30, 2026
    NIH
    NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sengupta S, Das S, Crespo AC, Cornel AM, Patel AG, Mahadevan NR, Campisi M, Ali AK, Sharma B, Rowe JH, Huang H, Debruyne DN, Cerda ED, Krajewska M, Dries R, Chen M, Zhang S, Soriano L, Cohen MA, Versteeg R, Jaenisch R, Spranger S, Romee R, Miller BC, Barbie DA, Nierkens S, Dyer MA, Lieberman J, George RE. Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes. Nat Cancer. 2022 10; 3(10):1228-1246. PMID: 36138189.
    Citations: 1     Translation:Humans
  2. Deng W, Bai Y, Deng F, Pan Y, Mei S, Zheng Z, Min R, Wu Z, Li W, Miao R, Zhang Z, Kupper TS, Lieberman J, Liu X. Author Correction: Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature. 2022 Aug; 608(7923):E28. PMID: 35896754.
    Citations: 1     Fields:    
  3. Eskandari SK, Allos H, Al Dulaijan BS, Melhem G, Sulkaj I, Alhaddad JB, Saad AJ, Deban C, Chu P, Choi JY, Kollar B, Pomahac B, Riella LV, Berger SP, Sanders JSF, Lieberman J, Li L, Azzi JR. mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis. Front Immunol. 2022; 13:899975. PMID: 35757726; PMCID: PMC9229986.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez SE, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA. Inflammasome activation in infected macrophages drives COVID-19 pathology. Nature. 2022 06; 606(7914):585-593. PMID: 35483404; PMCID: PMC9288243.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  5. Junqueira C, Crespo Â, Ranjbar S, de Lacerda LB, Lewandrowski M, Ingber J, Parry B, Ravid S, Clark S, Schrimpf MR, Ho F, Beakes C, Margolin J, Russell N, Kays K, Boucau J, Das Adhikari U, Vora SM, Leger V, Gehrke L, Henderson LA, Janssen E, Kwon D, Sander C, Abraham J, Goldberg MB, Wu H, Mehta G, Bell S, Goldfeld AE, Filbin MR, Lieberman J. Fc?R-mediated SARS-CoV-2 infection of monocytes activates inflammation. Nature. 2022 06; 606(7914):576-584. PMID: 35385861.
    Citations: 22     Fields:    Translation:HumansCells
  6. Sefik E, Qu R, Junqueira C, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez S, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M, Lieberman J, Wilen CB, Kluger Y, Flavell RA. Inflammasome activation in infected macrophages drives COVID-19 pathology. bioRxiv. 2022 Apr 01. PMID: 34611663; PMCID: PMC8491846.
    Citations:    
  7. Vora SM, Fontana P, Mao T, Leger V, Zhang Y, Fu TM, Lieberman J, Gehrke L, Shi M, Wang L, Iwasaki A, Wu H. Targeting stem-loop 1 of the SARS-CoV-2 5' UTR to suppress viral translation and Nsp1 evasion. Proc Natl Acad Sci U S A. 2022 03 01; 119(9). PMID: 35149555; PMCID: PMC8892331.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  8. Deng W, Bai Y, Deng F, Pan Y, Mei S, Zheng Z, Min R, Wu Z, Li W, Miao R, Zhang Z, Kupper TS, Lieberman J, Liu X. Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature. 2022 02; 602(7897):496-502. PMID: 35110732; PMCID: PMC9703647.
    Citations: 11     Fields:    Translation:AnimalsCells
  9. Meza-Sosa KF, Miao R, Navarro F, Zhang Z, Zhang Y, Hu JJ, Hartford CCR, Li XL, Pedraza-Alva G, Pérez-Martínez L, Lal A, Wu H, Lieberman J. SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage. Mol Cell. 2022 02 17; 82(4):785-802.e10. PMID: 35104452.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  10. Sen Santara S, Crespo ÂC, Mulik S, Ovies C, Boulenouar S, Strominger JL, Lieberman J. Decidual NK cells kill Zika virus-infected trophoblasts. Proc Natl Acad Sci U S A. 2021 11 23; 118(47). PMID: 34785597; PMCID: PMC8617421.
    Citations: 4     Fields:    Translation:AnimalsCells
  11. Fillmore N, Bell S, Shen C, Nguyen V, La J, Dubreuil M, Strymish J, Brophy M, Mehta G, Wu H, Lieberman J, Do N, Sander C. Disulfiram use is associated with lower risk of COVID-19: A retrospective cohort study. PLoS One. 2021; 16(10):e0259061. PMID: 34710137.
    Citations: 13     Fields:    Translation:HumansCells
  12. Wang C, Yang T, Xiao J, Xu C, Alippe Y, Sun K, Kanneganti TD, Monahan JB, Abu-Amer Y, Lieberman J, Mbalaviele G. NLRP3 inflammasome activation triggers gasdermin D-independent inflammation. Sci Immunol. 2021 Oct 22; 6(64):eabj3859. PMID: 34678046; PMCID: PMC8780201.
    Citations: 7     Fields:    Translation:AnimalsCells
  13. Gao W, Li Y, Liu X, Wang S, Mei P, Chen Z, Liu K, Li S, Xu XW, Gan J, Wu J, Ji C, Ding C, Liu X, Lai Y, He HH, Lieberman J, Wu H, Chen X, Li J. TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization. Cell Death Differ. 2022 02; 29(2):439-450. PMID: 34511601; PMCID: PMC8817046.
    Citations: 4     Fields:    Translation:Animals
  14. Junqueira C, Crespo Â, Ranjbar S, Lewandrowski M, Ingber J, de Lacerda LB, Parry B, Ravid S, Clark S, Ho F, Vora SM, Leger V, Beakes C, Margolin J, Russell N, Kays K, Gehrke L, Adhikari UD, Henderson L, Janssen E, Kwon D, Sander C, Abraham J, Filbin M, Goldberg MB, Wu H, Mehta G, Bell S, Goldfeld AE, Lieberman J. SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release. Res Sq. 2021 Aug 11. PMID: 34401873; PMCID: PMC8366805.
    Citations:    
  15. Vora SM, Lieberman J, Wu H. Inflammasome activation at the crux of severe COVID-19. Nat Rev Immunol. 2021 11; 21(11):694-703. PMID: 34373622; PMCID: PMC8351223.
    Citations: 46     Fields:    Translation:HumansAnimals
  16. Zheng Z, Deng W, Bai Y, Miao R, Mei S, Zhang Z, Pan Y, Wang Y, Min R, Deng F, Wu Z, Li W, Chen P, Ma T, Lou X, Lieberman J, Liu X. The Lysosomal Rag-Ragulator Complex Licenses RIPK1 and Caspase-8-mediated Pyroptosis by Yersinia. Science. 2021 06 25; 372(6549). PMID: 35058659; PMCID: PMC8769499.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  17. Hong Z, Mei J, Li C, Bai G, Maimaiti M, Hu H, Yu W, Sun L, Zhang L, Cheng D, Liao Y, Li S, You Y, Sun H, Huang J, Liu X, Lieberman J, Wang C. STING inhibitors target the cyclic dinucleotide binding pocket. Proc Natl Acad Sci U S A. 2021 06 15; 118(24). PMID: 34099558.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  18. Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, Wang L, Fu TM, Jacobson MP, Greka A, Lieberman J, Ruan J, Wu H. Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature. 2021 05; 593(7860):607-611. PMID: 33883744; PMCID: PMC8588876.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  19. Liu X, Xia S, Zhang Z, Wu H, Lieberman J. Channelling inflammation: gasdermins in physiology and disease. Nat Rev Drug Discov. 2021 05; 20(5):384-405. PMID: 33692549; PMCID: PMC7944254.
    Citations: 55     Fields:    Translation:HumansAnimals
  20. Junqueira C, Crespo Â, Ranjbar S, Ingber J, Parry B, Ravid S, de Lacerda LB, Lewandrowski M, Clark S, Ho F, Vora SM, Leger V, Beakes C, Margolin J, Russell N, Gehrke L, Adhikari UD, Henderson L, Janssen E, Kwon D, Sander C, Abraham J, Filbin M, Goldberg MB, Wu H, Mehta G, Bell S, Goldfeld AE, Lieberman J. SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release. medRxiv. 2021 Mar 08. PMID: 33758872; PMCID: PMC7987031.
    Citations: 1     
  21. Zhang Y, Xie X, Yeganeh PN, Lee DJ, Valle-Garcia D, Meza-Sosa KF, Junqueira C, Su J, Luo HR, Hide W, Lieberman J. Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown. Proc Natl Acad Sci U S A. 2021 03 02; 118(9). PMID: 33627408; PMCID: PMC7936362.
    Citations: 5     Fields:    Translation:HumansAnimals
  22. Junqueira C, Polidoro RB, Castro G, Absalon S, Liang Z, Sen Santara S, Crespo Â, Pereira DB, Gazzinelli RT, Dvorin JD, Lieberman J. ?d T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis. Nat Immunol. 2021 03; 22(3):347-357. PMID: 33432229; PMCID: PMC7906917.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  23. Zhang Z, Zhang Y, Lieberman J. Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity? Cancer Immunol Res. 2021 01; 9(1):2-7. PMID: 33397791; PMCID: PMC7789047.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  24. Zhang Z, Lieberman J. Lighting a fire on the reef. Sci Immunol. 2020 12 04; 5(54). PMID: 33277372.
    Citations: 2     Fields:    Translation:Animals
  25. Rosenblum D, Gutkin A, Kedmi R, Ramishetti S, Veiga N, Jacobi AM, Schubert MS, Friedmann-Morvinski D, Cohen ZR, Behlke MA, Lieberman J, Peer D. CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy. Sci Adv. 2020 11; 6(47). PMID: 33208369; PMCID: PMC7673804.
    Citations: 49     Fields:    
  26. Shi M, Wang L, Fontana P, Vora S, Zhang Y, Fu TM, Lieberman J, Wu H. SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism. bioRxiv. 2020 Sep 18. PMID: 32995777; PMCID: PMC7523103.
    Citations:    
  27. Hojo-Souza NS, de Azevedo PO, de Castro JT, Teixeira-Carvalho A, Lieberman J, Junqueira C, Gazzinelli RT. Contributions of IFN-? and granulysin to the clearance of Plasmodium yoelii blood stage. PLoS Pathog. 2020 09; 16(9):e1008840. PMID: 32913355; PMCID: PMC7482970.
    Citations: 4     Fields:    Translation:AnimalsCells
  28. Crespo ÂC, Mulik S, Dotiwala F, Ansara JA, Sen Santara S, Ingersoll K, Ovies C, Junqueira C, Tilburgs T, Strominger JL, Lieberman J. Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts. Cell. 2020 09 03; 182(5):1125-1139.e18. PMID: 32822574; PMCID: PMC7484179.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  29. Huang L, Deighan P, Jin J, Li Y, Cheung HC, Lee E, Mo SS, Hoover H, Abubucker S, Finkel N, McReynolds L, Hochschild A, Lieberman J. Tombusvirus p19 Captures RNase III-Cleaved Double-Stranded RNAs Formed by Overlapping Sense and Antisense Transcripts in Escherichia coli. mBio. 2020 06 09; 11(3). PMID: 32518184.
    Citations: 2     Fields:    Translation:Cells
  30. Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J, Wu H. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nat Immunol. 2020 07; 21(7):736-745. PMID: 32367036; PMCID: PMC7316630.
    Citations: 140     Fields:    Translation:HumansAnimalsCells
  31. Zhang Z, Zhang Y, Xia S, Kong Q, Li S, Liu X, Junqueira C, Meza-Sosa KF, Mok TMY, Ansara J, Sengupta S, Yao Y, Wu H, Lieberman J. Gasdermin E suppresses tumour growth by activating anti-tumour immunity. Nature. 2020 03; 579(7799):415-420. PMID: 32188940.
    Citations: 236     Fields:    Translation:HumansAnimalsCells
  32. Liu X, Lieberman J. Knocking 'em Dead: Pore-Forming Proteins in Immune Defense. Annu Rev Immunol. 2020 04 26; 38:455-485. PMID: 32004099.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  33. Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, Thomas M, Lieberman J, McInerney GM, Ivanov P, Anderson P. Correction: G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol. 2020 Jan 06; 219(1). PMID: 31851327; PMCID: PMC7039196.
    Citations: 1     Fields:    
  34. Lieberman J, Wu H, Kagan JC. Gasdermin D activity in inflammation and host defense. Sci Immunol. 2019 09 06; 4(39). PMID: 31492708.
    Citations: 42     Fields:    Translation:HumansAnimals
  35. Dotiwala F, Lieberman J. Granulysin: killer lymphocyte safeguard against microbes. Curr Opin Immunol. 2019 10; 60:19-29. PMID: 31112765; PMCID: PMC6800608.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  36. Vu LT, Peng B, Zhang DX, Ma V, Mathey-Andrews CA, Lam CK, Kiomourtzis T, Jin J, McReynolds L, Huang L, Grimson A, Cho WC, Lieberman J, Le MT. Tumor-secreted extracellular vesicles promote the activation of cancer-associated fibroblasts via the transfer of microRNA-125b. J Extracell Vesicles. 2019; 8(1):1599680. PMID: 31044053; PMCID: PMC6484490.
    Citations: 37     Fields:    
  37. Trifonova RT, Bollman B, Barteneva NS, Lieberman J. Myeloid Cells in Intact Human Cervical Explants Capture HIV and Can Transmit It to CD4 T Cells. Front Immunol. 2018; 9:2719. PMID: 30532754.
    Citations: 17     Fields:    Translation:HumansCells
  38. Lieberman J. Unveiling the RNA World. N Engl J Med. 2018 09 27; 379(13):1278-1280. PMID: 30200806.
    Citations: 1     Fields:    Translation:Humans
  39. Junqueira C, Barbosa CRR, Costa PAC, Teixeira-Carvalho A, Castro G, Sen Santara S, Barbosa RP, Dotiwala F, Pereira DB, Antonelli LR, Lieberman J, Gazzinelli RT. Cytotoxic CD8+ T cells recognize and kill Plasmodium vivax-infected reticulocytes. Nat Med. 2018 09; 24(9):1330-1336. PMID: 30038217.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  40. Meyer SE, Muench DE, Rogers AM, Newkold TJ, Orr E, O'Brien E, Perentesis JP, Doench JG, Lal A, Morris PJ, Thomas CJ, Lieberman J, McGlinn E, Aronow BJ, Salomonis N, Grimes HL. miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential. J Exp Med. 2018 08 06; 215(8):2115-2136. PMID: 29997117; PMCID: PMC6080909.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  41. Liu X, Fu R, Pan Y, Meza-Sosa KF, Zhang Z, Lieberman J. PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs. Cell. 2018 06 28; 174(1):187-201.e12. PMID: 29779946.
    Citations: 24     Fields:    Translation:HumansCells
  42. Ruan J, Xia S, Liu X, Lieberman J, Wu H. Cryo-EM structure of the gasdermin A3 membrane pore. Nature. 2018 05; 557(7703):62-67. PMID: 29695864; PMCID: PMC6007975.
    Citations: 128     Fields:    Translation:HumansAnimalsCells
  43. Clayton KL, Collins DR, Lengieza J, Ghebremichael M, Dotiwala F, Lieberman J, Walker BD. Resistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system. Nat Immunol. 2018 05; 19(5):475-486. PMID: 29670239; PMCID: PMC6025741.
    Citations: 44     Fields:    Translation:HumansCells
  44. Lieberman J. Tapping the RNA world for therapeutics. Nat Struct Mol Biol. 2018 05; 25(5):357-364. PMID: 29662218.
    Citations: 66     Fields:    Translation:HumansCells
  45. Doan M, Vorobjev I, Rees P, Filby A, Wolkenhauer O, Goldfeld AE, Lieberman J, Barteneva N, Carpenter AE, Hennig H. Diagnostic Potential of Imaging Flow Cytometry. Trends Biotechnol. 2018 07; 36(7):649-652. PMID: 29395345.
    Citations: 26     Fields:    Translation:HumansCells
  46. Kedmi R, Veiga N, Ramishetti S, Goldsmith M, Rosenblum D, Dammes N, Hazan-Halevy I, Nahary L, Leviatan-Ben-Arye S, Harlev M, Behlke M, Benhar I, Lieberman J, Peer D. A modular platform for targeted RNAi therapeutics. Nat Nanotechnol. 2018 03; 13(3):214-219. PMID: 29379205.
    Citations: 58     Fields:    Translation:AnimalsCells
  47. Sula Karreci E, Eskandari SK, Dotiwala F, Routray SK, Kurdi AT, Assaker JP, Luckyanchykov P, Mihali AB, Maarouf O, Borges TJ, Alkhudhayri A, Patel KR, Radwan A, Ghobrial I, McGrath M, Chandraker A, Riella LV, Elyaman W, Abdi R, Lieberman J, Azzi J. Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation. JCI Insight. 2017 11 02; 2(21). PMID: 29093262.
    Citations: 15     Fields:    Translation:HumansCells
  48. Dotiwala F, Sen Santara S, Binker-Cosen AA, Li B, Chandrasekaran S, Lieberman J. Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program. Cell. 2017 Nov 16; 171(5):1125-1137.e11. PMID: 29107333.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  49. Chan S, Sridhar P, Kirchner R, Lock YJ, Herbert Z, Buonamici S, Smith P, Lieberman J, Petrocca F. Basal-A Triple-Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival. Mol Cancer Ther. 2017 Dec; 16(12):2849-2861. PMID: 28878028; PMCID: PMC5997774.
    Citations: 20     Fields:    Translation:HumansCells
  50. Deruaz M, Murooka TT, Ji S, Gavin MA, Vrbanac VD, Lieberman J, Tager AM, Mempel TR, Luster AD. Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa. JCI Insight. 2017 04 06; 2(7):e88533. PMID: 28405607.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  51. Liu X, Lieberman J. A Mechanistic Understanding of Pyroptosis: The Fiery Death Triggered by Invasive Infection. Adv Immunol. 2017; 135:81-117. PMID: 28826530.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  52. Su S, Liao J, Liu J, Huang D, He C, Chen F, Yang L, Wu W, Chen J, Lin L, Zeng Y, Ouyang N, Cui X, Yao H, Su F, Huang JD, Lieberman J, Liu Q, Song E. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res. 2017 Apr; 27(4):461-482. PMID: 28290464; PMCID: PMC5385617.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  53. Liu X, Lieberman J. How ICE lights the pyroptosis fire. Cell Death Differ. 2017 02; 24(2):197-199. PMID: 28060375; PMCID: PMC5299720.
    Citations: 3     Fields:    Translation:Humans
  54. Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 2016 07 07; 535(7610):153-8. PMID: 27383986; PMCID: PMC5539988.
    Citations: 828     Fields:    Translation:HumansAnimalsCells
  55. Wheeler LA, Trifonova RT, Vrbanac V, Barteneva NS, Liu X, Bollman B, Onofrey L, Mulik S, Ranjbar S, Luster AD, Tager AM, Lieberman J. TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice. Cell Rep. 2016 05 24; 15(8):1715-27. PMID: 27184854.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  56. Boulias K, Lieberman J, Greer EL. An Epigenetic Clock Measures Accelerated Aging in Treated HIV Infection. Mol Cell. 2016 04 21; 62(2):153-155. PMID: 27105110; PMCID: PMC5315270.
    Citations: 13     Fields:    Translation:HumansCells
  57. Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, Thomas M, Lieberman J, McInerney GM, Ivanov P, Anderson P. G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol. 2016 Mar 28; 212(7):845-60. PMID: 27022092; PMCID: PMC4810302.
    Citations: 205     Fields:    Translation:HumansAnimalsCells
  58. Basu R, Whitlock BM, Husson J, Le Floc'h A, Jin W, Oyler-Yaniv A, Dotiwala F, Giannone G, Hivroz C, Biais N, Lieberman J, Kam LC, Huse M. Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing. Cell. 2016 Mar 24; 165(1):100-110. PMID: 26924577.
    Citations: 128     Fields:    Translation:AnimalsCells
  59. Dotiwala F, Mulik S, Polidoro RB, Ansara JA, Burleigh BA, Walch M, Gazzinelli RT, Lieberman J. Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites. Nat Med. 2016 Feb; 22(2):210-6. PMID: 26752517.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  60. Tan SM, Lieberman J. Capture and Identification of miRNA Targets by Biotin Pulldown and RNA-seq. Methods Mol Biol. 2016; 1358:211-28. PMID: 26463386.
    Citations: 21     Fields:    
  61. Weinstein S, Toker IA, Emmanuel R, Ramishetti S, Hazan-Halevy I, Rosenblum D, Goldsmith M, Abraham A, Benjamini O, Bairey O, Raanani P, Nagler A, Lieberman J, Peer D. Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies. Proc Natl Acad Sci U S A. 2016 Jan 05; 113(1):E16-22. PMID: 26699502; PMCID: PMC4711827.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  62. Wittrup A, Lieberman J. Knocking down disease: a progress report on siRNA therapeutics. Nat Rev Genet. 2015 Sep; 16(9):543-52. PMID: 26281785; PMCID: PMC4756474.
    Citations: 235     Fields:    Translation:HumansAnimals
  63. Gilboa-Geffen A, Hamar P, Le MT, Wheeler LA, Trifonova R, Petrocca F, Wittrup A, Lieberman J. Gene Knockdown by EpCAM Aptamer-siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells. Mol Cancer Ther. 2015 Oct; 14(10):2279-91. PMID: 26264278.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  64. Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J. Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown. Nat Biotechnol. 2015 Aug; 33(8):870-6. PMID: 26192320; PMCID: PMC4663660.
    Citations: 146     Fields:    Translation:HumansCells
  65. Navarro F, Lieberman J. miR-34 and p53: New Insights into a Complex Functional Relationship. PLoS One. 2015; 10(7):e0132767. PMID: 26177460; PMCID: PMC4503669.
    Citations: 78     Fields:    Translation:HumansCells
  66. Lieberman J. Manipulating the in vivo immune response by targeted gene knockdown. Curr Opin Immunol. 2015 Aug; 35:63-72. PMID: 26149459; PMCID: PMC4498257.
    Citations: 4     Fields:    Translation:HumansAnimals
  67. Dotiwala F, Fellay I, Filgueira L, Martinvalet D, Lieberman J, Walch M. A High Yield and Cost-efficient Expression System of Human Granzymes in Mammalian Cells. J Vis Exp. 2015 Jun 10; (100):e52911. PMID: 26132420.
    Citations: 7     Fields:    Translation:HumansCells
  68. O'Day E, Le MTN, Imai S, Tan SM, Kirchner R, Arthanari H, Hofmann O, Wagner G, Lieberman J. An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates. J Biol Chem. 2015 Jul 17; 290(29):17909-17922. PMID: 26045559.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  69. Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J. Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes. Cell. 2015 May 21; 161(5):1229. PMID: 28910642.
    Citations: 8     Fields:    
  70. Thomas MP, Liu X, Whangbo J, McCrossan G, Sanborn KB, Basar E, Walch M, Lieberman J. Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2. Cell Rep. 2015 May 19; 11(7):1079-89. PMID: 25959823.
    Citations: 57     Fields:    Translation:HumansCells
  71. Sharei A, Trifonova R, Jhunjhunwala S, Hartoularos GC, Eyerman AT, Lytton-Jean A, Angin M, Sharma S, Poceviciute R, Mao S, Heimann M, Liu S, Talkar T, Khan OF, Addo M, von Andrian UH, Anderson DG, Langer R, Lieberman J, Jensen KF. Ex vivo cytosolic delivery of functional macromolecules to immune cells. PLoS One. 2015; 10(4):e0118803. PMID: 25875117.