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Judy Lieberman, M.D., Ph.D.

Title
Institution
Department
Address
Phone
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Mentoring
completed student projects
Synthesis of a bifunctional chimera: Discriminate delivery of siRNA to CD4+ cells by fusion to RNA-based aptamers
Summer, 01/02/07 - 08/15/07
Understanding the role of tumor-derived extracellular vesicles in breast cancer metastasis
Summer, 06/05/15 - 08/28/15

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01CA240955 (LIEBERMAN, JUDY) Apr 3, 2020 - Mar 31, 2025
    NIH
    Gasdermin E and pyroptosis in cancer
    Role: Principal Investigator
  2. R21AI150671 (LIEBERMAN, JUDY) Mar 1, 2020 - Feb 28, 2022
    NIH
    Endogenous ligand of the NK activating receptor NKp46
    Role: Principal Investigator
  3. R01AI145862 (LIEBERMAN, JUDY) Jun 19, 2019 - May 31, 2024
    NIH
    Decidual NK response to infection
    Role: Principal Investigator
  4. R21AI131632 (GAZZINELLI, RICARDO) Jan 9, 2018 - Dec 31, 2019
    NIH
    Killing of P. vivax infected reticulocytes by cytotoxic T cells
    Role: Co-Principal Investigator
  5. R01AI124491 (WU, HAO) Jul 1, 2016 - Jun 30, 2021
    NIH
    Mechanistic Elucidation of Inflammasome Assembly and Regulation
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, Wang L, Fu TM, Jacobson MP, Greka A, Lieberman J, Ruan J, Wu H. Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature. 2021 Apr 21. PMID: 33883744.
    Citations:    Fields:    
  2. Liu X, Xia S, Zhang Z, Wu H, Lieberman J. Channelling inflammation: gasdermins in physiology and disease. Nat Rev Drug Discov. 2021 May; 20(5):384-405. PMID: 33692549.
    Citations:    Fields:    
  3. Junqueira C, Crespo Â, Ranjbar S, Ingber J, Parry B, Ravid S, de Lacerda LB, Lewandrowski M, Clark S, Ho F, Vora SM, Leger V, Beakes C, Margolin J, Russell N, Gehrke L, Adhikari UD, Henderson L, Janssen E, Kwon D, Sander C, Abraham J, Filbin M, Goldberg MB, Wu H, Mehta G, Bell S, Goldfeld AE, Lieberman J. SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release. medRxiv. 2021 Mar 08. PMID: 33758872.
    Citations:    
  4. Zhang Y, Xie X, Yeganeh PN, Lee DJ, Valle-Garcia D, Meza-Sosa KF, Junqueira C, Su J, Luo HR, Hide W, Lieberman J. Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown. Proc Natl Acad Sci U S A. 2021 Mar 02; 118(9). PMID: 33627408.
    Citations: 1     Fields:    
  5. Junqueira C, Polidoro RB, Castro G, Absalon S, Liang Z, Sen Santara S, Crespo Â, Pereira DB, Gazzinelli RT, Dvorin JD, Lieberman J. ?d T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis. Nat Immunol. 2021 03; 22(3):347-357. PMID: 33432229.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Zhang Z, Zhang Y, Lieberman J. Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity? Cancer Immunol Res. 2021 01; 9(1):2-7. PMID: 33397791.
    Citations:    Fields:    
  7. Zhang Z, Lieberman J. Lighting a fire on the reef. Sci Immunol. 2020 12 04; 5(54). PMID: 33277372.
    Citations:    Fields:    
  8. Rosenblum D, Gutkin A, Kedmi R, Ramishetti S, Veiga N, Jacobi AM, Schubert MS, Friedmann-Morvinski D, Cohen ZR, Behlke MA, Lieberman J, Peer D. CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy. Sci Adv. 2020 Nov; 6(47). PMID: 33208369.
    Citations: 7     Fields:    
  9. Shi M, Wang L, Fontana P, Vora S, Zhang Y, Fu TM, Lieberman J, Wu H. SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism. bioRxiv. 2020 Sep 18. PMID: 32995777.
    Citations:    
  10. Hojo-Souza NS, de Azevedo PO, de Castro JT, Teixeira-Carvalho A, Lieberman J, Junqueira C, Gazzinelli RT. Contributions of IFN-? and granulysin to the clearance of Plasmodium yoelii blood stage. PLoS Pathog. 2020 09; 16(9):e1008840. PMID: 32913355.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Crespo ÂC, Mulik S, Dotiwala F, Ansara JA, Sen Santara S, Ingersoll K, Ovies C, Junqueira C, Tilburgs T, Strominger JL, Lieberman J. Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts. Cell. 2020 09 03; 182(5):1125-1139.e18. PMID: 32822574.
    Citations: 1     Fields:    
  12. Huang L, Deighan P, Jin J, Li Y, Cheung HC, Lee E, Mo SS, Hoover H, Abubucker S, Finkel N, McReynolds L, Hochschild A, Lieberman J. Tombusvirus p19 Captures RNase III-Cleaved Double-Stranded RNAs Formed by Overlapping Sense and Antisense Transcripts in Escherichia coli. mBio. 2020 06 09; 11(3). PMID: 32518184.
    Citations: 1     Fields:    Translation:Cells
  13. Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J, Wu H. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nat Immunol. 2020 07; 21(7):736-745. PMID: 32367036.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  14. Zhang Z, Zhang Y, Xia S, Kong Q, Li S, Liu X, Junqueira C, Meza-Sosa KF, Mok TMY, Ansara J, Sengupta S, Yao Y, Wu H, Lieberman J. Gasdermin E suppresses tumour growth by activating anti-tumour immunity. Nature. 2020 03; 579(7799):415-420. PMID: 32188940.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  15. Liu X, Lieberman J. Knocking 'em Dead: Pore-Forming Proteins in Immune Defense. Annu Rev Immunol. 2020 04 26; 38:455-485. PMID: 32004099.
    Citations: 8     Fields:    
  16. Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, Thomas M, Lieberman J, McInerney GM, Ivanov P, Anderson P. Correction: G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol. 2020 Jan 06; 219(1). PMID: 31851327.
    Citations:    Fields:    
  17. Lieberman J, Wu H, Kagan JC. Gasdermin D activity in inflammation and host defense. Sci Immunol. 2019 09 06; 4(39). PMID: 31492708.
    Citations: 18     Fields:    Translation:HumansAnimals
  18. Dotiwala F, Lieberman J. Granulysin: killer lymphocyte safeguard against microbes. Curr Opin Immunol. 2019 10; 60:19-29. PMID: 31112765.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  19. Vu LT, Peng B, Zhang DX, Ma V, Mathey-Andrews CA, Lam CK, Kiomourtzis T, Jin J, McReynolds L, Huang L, Grimson A, Cho WC, Lieberman J, Le MT. Tumor-secreted extracellular vesicles promote the activation of cancer-associated fibroblasts via the transfer of microRNA-125b. J Extracell Vesicles. 2019; 8(1):1599680. PMID: 31044053.
    Citations: 24     
  20. Trifonova RT, Bollman B, Barteneva NS, Lieberman J. Myeloid Cells in Intact Human Cervical Explants Capture HIV and Can Transmit It to CD4 T Cells. Front Immunol. 2018; 9:2719. PMID: 30532754.
    Citations: 10     Fields:    Translation:HumansCells
  21. Lieberman J. Unveiling the RNA World. N Engl J Med. 2018 09 27; 379(13):1278-1280. PMID: 30200806.
    Citations: 1     Fields:    Translation:Humans
  22. Junqueira C, Barbosa CRR, Costa PAC, Teixeira-Carvalho A, Castro G, Sen Santara S, Barbosa RP, Dotiwala F, Pereira DB, Antonelli LR, Lieberman J, Gazzinelli RT. Cytotoxic CD8+ T cells recognize and kill Plasmodium vivax-infected reticulocytes. Nat Med. 2018 09; 24(9):1330-1336. PMID: 30038217.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  23. Meyer SE, Muench DE, Rogers AM, Newkold TJ, Orr E, O'Brien E, Perentesis JP, Doench JG, Lal A, Morris PJ, Thomas CJ, Lieberman J, McGlinn E, Aronow BJ, Salomonis N, Grimes HL. miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential. J Exp Med. 2018 08 06; 215(8):2115-2136. PMID: 29997117.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  24. Liu X, Fu R, Pan Y, Meza-Sosa KF, Zhang Z, Lieberman J. PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs. Cell. 2018 06 28; 174(1):187-201.e12. PMID: 29779946.
    Citations: 15     Fields:    Translation:HumansCells
  25. Ruan J, Xia S, Liu X, Lieberman J, Wu H. Cryo-EM structure of the gasdermin A3 membrane pore. Nature. 2018 05; 557(7703):62-67. PMID: 29695864.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  26. Clayton KL, Collins DR, Lengieza J, Ghebremichael M, Dotiwala F, Lieberman J, Walker BD. Resistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system. Nat Immunol. 2018 05; 19(5):475-486. PMID: 29670239.
    Citations: 20     Fields:    Translation:HumansCells
  27. Lieberman J. Tapping the RNA world for therapeutics. Nat Struct Mol Biol. 2018 05; 25(5):357-364. PMID: 29662218.
    Citations: 42     Fields:    Translation:HumansCells
  28. Doan M, Vorobjev I, Rees P, Filby A, Wolkenhauer O, Goldfeld AE, Lieberman J, Barteneva N, Carpenter AE, Hennig H. Diagnostic Potential of Imaging Flow Cytometry. Trends Biotechnol. 2018 07; 36(7):649-652. PMID: 29395345.
    Citations: 10     Fields:    Translation:HumansCells
  29. Kedmi R, Veiga N, Ramishetti S, Goldsmith M, Rosenblum D, Dammes N, Hazan-Halevy I, Nahary L, Leviatan-Ben-Arye S, Harlev M, Behlke M, Benhar I, Lieberman J, Peer D. A modular platform for targeted RNAi therapeutics. Nat Nanotechnol. 2018 03; 13(3):214-219. PMID: 29379205.
    Citations: 30     Fields:    Translation:AnimalsCells
  30. Sula Karreci E, Eskandari SK, Dotiwala F, Routray SK, Kurdi AT, Assaker JP, Luckyanchykov P, Mihali AB, Maarouf O, Borges TJ, Alkhudhayri A, Patel KR, Radwan A, Ghobrial I, McGrath M, Chandraker A, Riella LV, Elyaman W, Abdi R, Lieberman J, Azzi J. Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation. JCI Insight. 2017 11 02; 2(21). PMID: 29093262.
    Citations: 7     Fields:    Translation:HumansCells
  31. Dotiwala F, Sen Santara S, Binker-Cosen AA, Li B, Chandrasekaran S, Lieberman J. Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program. Cell. 2017 Nov 16; 171(5):1125-1137.e11. PMID: 29107333.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  32. Chan S, Sridhar P, Kirchner R, Lock YJ, Herbert Z, Buonamici S, Smith P, Lieberman J, Petrocca F. Basal-A Triple-Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival. . 2017 Dec; 16(12):2849-2861. PMID: 28878028.
    Citations: 10     Translation:HumansCells
  33. Deruaz M, Murooka TT, Ji S, Gavin MA, Vrbanac VD, Lieberman J, Tager AM, Mempel TR, Luster AD. Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa. JCI Insight. 2017 04 06; 2(7):e88533. PMID: 28405607.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  34. Liu X, Lieberman J. A Mechanistic Understanding of Pyroptosis: The Fiery Death Triggered by Invasive Infection. Adv Immunol. 2017; 135:81-117. PMID: 28826530.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  35. Su S, Liao J, Liu J, Huang D, He C, Chen F, Yang L, Wu W, Chen J, Lin L, Zeng Y, Ouyang N, Cui X, Yao H, Su F, Huang JD, Lieberman J, Liu Q, Song E. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res. 2017 Apr; 27(4):461-482. PMID: 28290464.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  36. Liu X, Lieberman J. How ICE lights the pyroptosis fire. Cell Death Differ. 2017 02; 24(2):197-199. PMID: 28060375.
    Citations: 1     Fields:    Translation:Humans
  37. Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 2016 07 07; 535(7610):153-8. PMID: 27383986.
    Citations: 441     Fields:    Translation:HumansAnimalsCells
  38. Wheeler LA, Trifonova RT, Vrbanac V, Barteneva NS, Liu X, Bollman B, Onofrey L, Mulik S, Ranjbar S, Luster AD, Tager AM, Lieberman J. TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice. Cell Rep. 2016 05 24; 15(8):1715-27. PMID: 27184854.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  39. Boulias K, Lieberman J, Greer EL. An Epigenetic Clock Measures Accelerated Aging in Treated HIV Infection. Mol Cell. 2016 04 21; 62(2):153-155. PMID: 27105110.
    Citations: 8     Fields:    Translation:HumansCells
  40. Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, Thomas M, Lieberman J, McInerney GM, Ivanov P, Anderson P. G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol. 2016 Mar 28; 212(7):845-60. PMID: 27022092.
    Citations: 138     Fields:    Translation:HumansAnimalsCells
  41. Basu R, Whitlock BM, Husson J, Le Floc'h A, Jin W, Oyler-Yaniv A, Dotiwala F, Giannone G, Hivroz C, Biais N, Lieberman J, Kam LC, Huse M. Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing. Cell. 2016 Mar 24; 165(1):100-110. PMID: 26924577.
    Citations: 73     Fields:    Translation:AnimalsCells
  42. Dotiwala F, Mulik S, Polidoro RB, Ansara JA, Burleigh BA, Walch M, Gazzinelli RT, Lieberman J. Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites. Nat Med. 2016 Feb; 22(2):210-6. PMID: 26752517.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  43. Tan SM, Lieberman J. Capture and Identification of miRNA Targets by Biotin Pulldown and RNA-seq. Methods Mol Biol. 2016; 1358:211-28. PMID: 26463386.
    Citations: 10     Fields:    
  44. Weinstein S, Toker IA, Emmanuel R, Ramishetti S, Hazan-Halevy I, Rosenblum D, Goldsmith M, Abraham A, Benjamini O, Bairey O, Raanani P, Nagler A, Lieberman J, Peer D. Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies. Proc Natl Acad Sci U S A. 2016 Jan 05; 113(1):E16-22. PMID: 26699502.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  45. Wittrup A, Lieberman J. Knocking down disease: a progress report on siRNA therapeutics. Nat Rev Genet. 2015 Sep; 16(9):543-52. PMID: 26281785.
    Citations: 182     Fields:    Translation:HumansAnimals
  46. Gilboa-Geffen A, Hamar P, Le MT, Wheeler LA, Trifonova R, Petrocca F, Wittrup A, Lieberman J. Gene Knockdown by EpCAM Aptamer-siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells. . 2015 Oct; 14(10):2279-91. PMID: 26264278.
    Citations: 25     Translation:HumansAnimalsCells
  47. Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J. Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown. Nat Biotechnol. 2015 Aug; 33(8):870-6. PMID: 26192320.
    Citations: 86     Fields:    Translation:HumansCells
  48. Navarro F, Lieberman J. miR-34 and p53: New Insights into a Complex Functional Relationship. PLoS One. 2015; 10(7):e0132767. PMID: 26177460.
    Citations: 52     Fields:    Translation:HumansCells
  49. Lieberman J. Manipulating the in vivo immune response by targeted gene knockdown. Curr Opin Immunol. 2015 Aug; 35:63-72. PMID: 26149459.
    Citations: 3     Fields:    Translation:HumansAnimals
  50. Dotiwala F, Fellay I, Filgueira L, Martinvalet D, Lieberman J, Walch M. A High Yield and Cost-efficient Expression System of Human Granzymes in Mammalian Cells. J Vis Exp. 2015 Jun 10; (100):e52911. PMID: 26132420.
    Citations: 2     Fields:    Translation:HumansCells
  51. O'Day E, Le MTN, Imai S, Tan SM, Kirchner R, Arthanari H, Hofmann O, Wagner G, Lieberman J. An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates. J Biol Chem. 2015 Jul 17; 290(29):17909-17922. PMID: 26045559.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  52. Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J. Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes. Cell. 2015 May 21; 161(5):1229. PMID: 28910642.
    Citations: 6     Fields:    
  53. Thomas MP, Liu X, Whangbo J, McCrossan G, Sanborn KB, Basar E, Walch M, Lieberman J. Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2. Cell Rep. 2015 May 19; 11(7):1079-89. PMID: 25959823.
    Citations: 43     Fields:    Translation:HumansCells
  54. Sharei A, Trifonova R, Jhunjhunwala S, Hartoularos GC, Eyerman AT, Lytton-Jean A, Angin M, Sharma S, Poceviciute R, Mao S, Heimann M, Liu S, Talkar T, Khan OF, Addo M, von Andrian UH, Anderson DG, Langer R, Lieberman J, Jensen KF. Ex vivo cytosolic delivery of functional macromolecules to immune cells. PLoS One. 2015; 10(4):e0118803. PMID: 25875117.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  55. Luo ML, Gong C, Chen CH, Hu H, Huang P, Zheng M, Yao Y, Wei S, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation. Cell Rep. 2015 Apr 07; 11(1):111-24. PMID: 25818297.
    Citations: 43     Fields:    Translation:HumansCells
  56. Hata A, Lieberman J. Dysregulation of microRNA biogenesis and gene silencing in cancer. Sci Signal. 2015 Mar 17; 8(368):re3. PMID: 25783160.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  57. Lieberman J, Sharp PA. Harnessing RNA interference for therapy: the silent treatment. JAMA. 2015 Mar 24-31; 313(12):1207-8. PMID: 25803342.
    Citations: 2     Fields:    Translation:Humans
  58. Le MT, Hamar P, Guo C, Basar E, Perdigão-Henriques R, Balaj L, Lieberman J. miR-200-containing extracellular vesicles promote breast cancer cell metastasis. J Clin Invest. 2014 Dec; 124(12):5109-28. PMID: 25401471.
    Citations: 153     Fields:    Translation:HumansAnimalsCells
  59. Ivanov P, O'Day E, Emara MM, Wagner G, Lieberman J, Anderson P. G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18201-6. PMID: 25404306.
    Citations: 99     Fields:    Translation:HumansCells
  60. Wheeler LA, Lieberman J. Developing an Effective Rectal Microbicide: Inhibiting HIV Transmission in Human Colorectal Tissue and Humanized Mice with CD4 Aptamer-siRNA Chimeras. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A206. PMID: 25357578.
    Citations:    
  61. Wheeler LA, Lieberman J. Inhibiting the Host Exonuclease TREX1 Induces a Localized and Protective Host Interferon Response against Acute HIV Infection In Vivo. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A41. PMID: 25357849.
    Citations:    
  62. Tan SM, Kirchner R, Jin J, Hofmann O, McReynolds L, Hide W, Lieberman J. Sequencing of captive target transcripts identifies the network of regulated genes and functions of primate-specific miR-522. Cell Rep. 2014 Aug 21; 8(4):1225-39. PMID: 25131211.
    Citations: 23     Fields:    Translation:HumansCells
  63. Tay Y, Tan SM, Karreth FA, Lieberman J, Pandolfi PP. Characterization of dual PTEN and p53-targeting microRNAs identifies microRNA-638/Dnm2 as a two-hit oncogenic locus. Cell Rep. 2014 Aug 07; 8(3):714-22. PMID: 25088422.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  64. Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J. Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes. Cell. 2014 Jun 05; 157(6):1309-1323. PMID: 24906149.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  65. Luo ML, Gong C, Chen CH, Lee DY, Hu H, Huang P, Yao Y, Guo W, Reinhardt F, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer. Cancer Res. 2014 Jul 01; 74(13):3603-16. PMID: 24786790.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  66. Thomas MP, Whangbo J, McCrossan G, Deutsch AJ, Martinod K, Walch M, Lieberman J. Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins. J Immunol. 2014 Jun 01; 192(11):5390-7. PMID: 24771851.
    Citations: 14     Fields:    Translation:HumansCellsCTClinical Trials
  67. Trifonova RT, Lieberman J, van Baarle D. Distribution of immune cells in the human cervix and implications for HIV transmission. Am J Reprod Immunol. 2014 Mar; 71(3):252-64. PMID: 24410939.
    Citations: 25     Fields:    Translation:HumansCells
  68. Thiery J, Lieberman J. Perforin: a key pore-forming protein for immune control of viruses and cancer. Subcell Biochem. 2014; 80:197-220. PMID: 24798013.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  69. Huang L, Lieberman J. Production of highly potent recombinant siRNAs in Escherichia coli. Nat Protoc. 2013 Dec; 8(12):2325-36. PMID: 24177290.
    Citations: 8     Fields:    Translation:HumansCells
  70. Tuli A, Thiery J, James AM, Michelet X, Sharma M, Garg S, Sanborn KB, Orange JS, Lieberman J, Brenner MB. Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. Mol Biol Cell. 2013 Dec; 24(23):3721-35. PMID: 24088571.
    Citations: 28     Fields:    Translation:HumansCells
  71. Petrocca F, Altschuler G, Tan SM, Mendillo ML, Yan H, Jerry DJ, Kung AL, Hide W, Ince TA, Lieberman J. A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells. Cancer Cell. 2013 Aug 12; 24(2):182-96. PMID: 23948298.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  72. Thomas MP, Lieberman J. Live or let die: posttranscriptional gene regulation in cell stress and cell death. Immunol Rev. 2013 May; 253(1):237-52. PMID: 23550650.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  73. Wheeler LA, Vrbanac V, Trifonova R, Brehm MA, Gilboa-Geffen A, Tanno S, Greiner DL, Luster AD, Tager AM, Lieberman J. Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras. Mol Ther. 2013 Jul; 21(7):1378-89. PMID: 23629001.
    Citations: 28     Fields:    Translation:HumansAnimals
  74. Lieberman J, Slack F, Pandolfi PP, Chinnaiyan A, Agami R, Mendell JT. Noncoding RNAs and cancer. Cell. 2013 Mar 28; 153(1):9-10. PMID: 23781554.
    Citations: 21     Fields:    Translation:HumansAnimals
  75. Huang L, Jin J, Deighan P, Kiner E, McReynolds L, Lieberman J. Efficient and specific gene knockdown by small interfering RNAs produced in bacteria. Nat Biotechnol. 2013 Apr; 31(4):350-6. PMID: 23475073.
    Citations: 24     Fields:    Translation:HumansCells
  76. Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N. Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nat Immunol. 2013 Feb; 14(2):179-85. PMID: 23263557.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  77. Yan N, Lieberman J. SAMHD1 does it again, now in resting T cells. Nat Med. 2012 Nov; 18(11):1611-2. PMID: 23135508.
    Citations: 5     Fields:    Translation:HumansCells
  78. Rajani DK, Walch M, Martinvalet D, Thomas MP, Lieberman J. Alterations in RNA processing during immune-mediated programmed cell death. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8688-93. PMID: 22589304.
    Citations: 12     Fields:    Translation:HumansCells
  79. Yao YD, Sun TM, Huang SY, Dou S, Lin L, Chen JN, Ruan JB, Mao CQ, Yu FY, Zeng MS, Zang JY, Liu Q, Su FX, Zhang P, Lieberman J, Wang J, Song E. Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis. Sci Transl Med. 2012 Apr 18; 4(130):130ra48. PMID: 22517885.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  80. Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A. Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem. 2012 Feb 03; 287(6):3976-86. PMID: 22158624.
    Citations: 44     Fields:    Translation:Humans
  81. Lal A, Thomas MP, Altschuler G, Navarro F, O'Day E, Li XL, Concepcion C, Han YC, Thiery J, Rajani DK, Deutsch A, Hofmann O, Ventura A, Hide W, Lieberman J. Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet. 2011 Nov; 7(11):e1002363. PMID: 22102825.
    Citations: 112     Fields:    Translation:HumansCells
  82. Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L, Provero P, Di Cunto F, Lieberman J, Rigoutsos I, Pandolfi PP. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell. 2011 Oct 14; 147(2):344-57. PMID: 22000013.
    Citations: 416     Fields:    Translation:HumansAnimalsCells
  83. Le MT, Shyh-Chang N, Khaw SL, Chin L, Teh C, Tay J, O'Day E, Korzh V, Yang H, Lal A, Lieberman J, Lodish HF, Lim B. Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet. 2011 Sep; 7(9):e1002242. PMID: 21935352.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  84. Lakhashe SK, Velu V, Sciaranghella G, Siddappa NB, Dipasquale JM, Hemashettar G, Yoon JK, Rasmussen RA, Yang F, Lee SJ, Montefiori DC, Novembre FJ, Villinger F, Amara RR, Kahn M, Hu SL, Li S, Li Z, Frankel FR, Robert-Guroff M, Johnson WE, Lieberman J, Ruprecht RM. Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges. Vaccine. 2011 Aug 05; 29(34):5611-22. PMID: 21693155.
    Citations: 21     Fields:    Translation:AnimalsCellsPHPublic Health
  85. Thiery J, Keefe D, Boulant S, Boucrot E, Walch M, Martinvalet D, Goping IS, Bleackley RC, Kirchhausen T, Lieberman J. Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat Immunol. 2011 Jun 19; 12(8):770-7. PMID: 21685908.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  86. Wheeler LA, Trifonova R, Vrbanac V, Basar E, McKernan S, Xu Z, Seung E, Deruaz M, Dudek T, Einarsson JI, Yang L, Allen TM, Luster AD, Tager AM, Dykxhoorn DM, Lieberman J. Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. J Clin Invest. 2011 Jun; 121(6):2401-12. PMID: 21576818.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  87. Yan N, O'Day E, Wheeler LA, Engelman A, Lieberman J. HIV DNA is heavily uracilated, which protects it from autointegration. Proc Natl Acad Sci U S A. 2011 May 31; 108(22):9244-9. PMID: 21576478.
    Citations: 33     Fields:    Translation:HumansCells
  88. Whitney JB, Mirshahidi S, Lim SY, Goins L, Ibegbu CC, Anderson DC, Raybourne RB, Frankel FR, Lieberman J, Ruprecht RM. Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV. J Immune Based Ther Vaccines. 2011 Jan 18; 9:2. PMID: 21244649.
    Citations: 5     
  89. Yan N, Lieberman J. Gaining a foothold: how HIV avoids innate immune recognition. Curr Opin Immunol. 2011 Feb; 23(1):21-8. PMID: 21123040.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  90. Petrocca F, Lieberman J. Promise and challenge of RNA interference-based therapy for cancer. J Clin Oncol. 2011 Feb 20; 29(6):747-54. PMID: 21079135.
    Citations: 44     Fields:    Translation:Humans
  91. Thomas M, Lieberman J, Lal A. Desperately seeking microRNA targets. Nat Struct Mol Biol. 2010 Oct; 17(10):1169-74. PMID: 20924405.
    Citations: 215     Fields:    Translation:HumansAnimalsCells
  92. Yan N, Regalado-Magdos AD, Stiggelbout B, Lee-Kirsch MA, Lieberman J. The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol. 2010 Nov; 11(11):1005-13. PMID: 20871604.
    Citations: 240     Fields:    Translation:HumansAnimalsCells
  93. Navarro F, Lieberman J. Small RNAs guide hematopoietic cell differentiation and function. J Immunol. 2010 Jun 01; 184(11):5939-47. PMID: 20483778.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  94. Thiery J, Walch M, Jensen DK, Martinvalet D, Lieberman J. Isolation of cytotoxic T cell and NK granules and purification of their effector proteins. Curr Protoc Cell Biol. 2010 Jun; Chapter 3:Unit3.37. PMID: 20521234.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  95. Lieberman J. Anatomy of a murder: how cytotoxic T cells and NK cells are activated, develop, and eliminate their targets. Immunol Rev. 2010 May; 235(1):5-9. PMID: 20536551.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  96. Lieberman J. Granzyme A activates another way to die. Immunol Rev. 2010 May; 235(1):93-104. PMID: 20536557.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  97. Niland B, Miklossy G, Banki K, Biddison WE, Casciola-Rosen L, Rosen A, Martinvalet D, Lieberman J, Perl A. Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients. J Immunol. 2010 Apr 01; 184(7):4025-32. PMID: 20194725.
    Citations: 10     Fields:    Translation:HumansCells
  98. Thiery J, Keefe D, Saffarian S, Martinvalet D, Walch M, Boucrot E, Kirchhausen T, Lieberman J. Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis. Blood. 2010 Feb 25; 115(8):1582-93. PMID: 20038786.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  99. Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A. Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J. 2010 Feb 03; 29(3):559-73. PMID: 20019669.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  100. Lieberman J. Micromanaging cancer. N Engl J Med. 2009 Oct 08; 361(15):1500-1. PMID: 19812408.
    Citations: 2     Fields:    Translation:Humans
  101. Dykxhoorn DM, Wu Y, Xie H, Yu F, Lal A, Petrocca F, Martinvalet D, Song E, Lim B, Lieberman J. miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS One. 2009 Sep 29; 4(9):e7181. PMID: 19787069.
    Citations: 163     Fields:    Translation:AnimalsCells
  102. Lal A, Navarro F, Maher CA, Maliszewski LE, Yan N, O'Day E, Chowdhury D, Dykxhoorn DM, Tsai P, Hofmann O, Becker KG, Gorospe M, Hide W, Lieberman J. miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell. 2009 Sep 11; 35(5):610-25. PMID: 19748357.
    Citations: 313     Fields:    Translation:HumansCells
  103. Petrocca F, Lieberman J. Micromanipulating cancer: microRNA-based therapeutics? RNA Biol. 2009 Jul-Aug; 6(3):335-40. PMID: 19535911.
    Citations: 13     Fields:    Translation:HumansAnimals
  104. Navarro F, Gutman D, Meire E, Cáceres M, Rigoutsos I, Bentwich Z, Lieberman J. miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53. Blood. 2009 Sep 03; 114(10):2181-92. PMID: 19584398.
    Citations: 66     Fields:    Translation:HumansCells
  105. Ahmed F, Friend S, George TC, Barteneva N, Lieberman J. Numbers matter: quantitative and dynamic analysis of the formation of an immunological synapse using imaging flow cytometry. J Immunol Methods. 2009 Aug 15; 347(1-2):79-86. PMID: 19524586.
    Citations: 14     Fields:    Translation:HumansCells