Harvard Catalyst Profiles
Contact, publication, and social network information about Harvard faculty and fellows.
Home
About
Overview
Open Source Software
Help
History (1)
Lieberman, Judy
See All Pages
Find People
Find Everything
Login
to
edit your profile
(add a photo, education, awards, etc.), search
student opportunities
, and
create reports
.
Edit My Profile
My Person List (
0
)
Opportunity Search
Return to Top
Judy Lieberman, M.D., Ph.D.
Title
Professor of Pediatrics
Institution
Immune Disease Institute
Department
Pediatrics
Address
Boston Children's Hospital
Warren Alpert Building 255
200 Longwood Ave
Boston MA 02115
Phone
617/713-8600
Fax
617/713-8620
vCard
Download vCard
(
login for email
)
completed student projects
|
research activities and funding
|
selected publications
|
Mentoring
completed student projects
Synthesis of a bifunctional chimera: Discriminate delivery of siRNA to CD4+ cells by fusion to RNA-based aptamers
Summer, 01/02/07 - 08/15/07
Understanding the role of tumor-derived extracellular vesicles in breast cancer metastasis
Summer, 06/05/15 - 08/28/15
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
R01CA240955
(LIEBERMAN, JUDY)
Apr 3, 2020 - Mar 31, 2025
NIH
Gasdermin E and pyroptosis in cancer
Role: Principal Investigator
R21AI150671
(LIEBERMAN, JUDY)
Mar 1, 2020 - Feb 28, 2022
NIH
Endogenous ligand of the NK activating receptor NKp46
Role: Principal Investigator
R01AI145862
(LIEBERMAN, JUDY)
Jun 19, 2019 - May 31, 2024
NIH
Decidual NK response to infection
Role: Principal Investigator
R21AI131632
(GAZZINELLI, RICARDO)
Jan 9, 2018 - Dec 31, 2019
NIH
Killing of P. vivax infected reticulocytes by cytotoxic T cells
Role: Co-Principal Investigator
R01AI124491
(WU, HAO)
Jul 1, 2016 - Jun 30, 2026
NIH
NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing
Role: Co-Principal Investigator
R21HD087689
(STROMINGER, JACK L)
Mar 4, 2016 - Feb 28, 2018
NIH
Control of placental infection by decidual NK cell secreted granulysin
Role: Principal Investigator
R01AI116577
(LIEBERMAN, JUDY)
Mar 1, 2016 - Feb 28, 2021
NIH
Granzyme and Granulysin Mediated Death of Trypanosoma cruzi
Role: Co-Principal Investigator
R01AI123265
(LIEBERMAN, JUDY)
Feb 15, 2016 - Jan 31, 2021
NIH
Granulysin, Granzymes and Perforin in Bacterial Immune Defense
Role: Principal Investigator
R01CA184718
(LIEBERMAN, JUDY)
Sep 24, 2015 - Aug 31, 2020
NIH
Aptamer-siRNA gene knockdown to treat epithelial triple negative breast cancer
Role: Principal Investigator
S10OD016401
(LIEBERMAN, JUDY)
Jul 15, 2013 - Jul 14, 2014
NIH
IVIS Spectrum for In Vivo Imaging
Role: Principal Investigator
R01AI102816
(LIEBERMAN, JUDY)
Jun 1, 2012 - May 31, 2017
NIH
Interferon Effects on HIV Transmission in Human Models
Role: Principal Investigator
RC4AI092695
(LIEBERMAN, JUDY)
Sep 30, 2010 - Sep 29, 2013
NIH
Knockdown of Gene Expression in Immune Cells in Humanized Mice
Role: Principal Investigator
R21AI087431
(LIEBERMAN, JUDY)
Sep 1, 2010 - Aug 31, 2012
NIH
Role of Host miRNAs in Persistent HIV Macrophage Infection
Role: Principal Investigator
R01AI090671
(LIEBERMAN, JUDY)
Jul 1, 2010 - Jun 30, 2015
NIH
CD4 aptamer-siRNA chimeras to prevent HIV transmission
Role: Principal Investigator
S10RR023459
(LIEBERMAN, JUDY)
Mar 20, 2007 - Dec 31, 2008
NIH
Biocontained ImageStream 100 Multispectral Imaging Cytometer
Role: Principal Investigator
U19AI070302
(LIEBERMAN, JUDY)
Sep 30, 2006 - Aug 31, 2011
NIH
An siRNA-based microbicide to prevent HIV transmission
Role: Principal Investigator
R01AI063430
(LIEBERMAN, JUDY)
Feb 15, 2006 - Jan 31, 2011
NIH
Mechanism of perforin activity
Role: Principal Investigator
R03TW007069
(LIEBERMAN, JUDY)
Apr 1, 2005 - Mar 31, 2008
NIH
RNAi to limit kidney ischemia/reperfusion injury
Role: Principal Investigator
R21AI058695
(LIEBERMAN, JUDY)
Feb 1, 2004 - Jan 31, 2007
NIH
Developing RNA Interference for and HIV microbicide
Role: Principal Investigator
P01AI054558
(LIEBERMAN, JUDY)
Aug 1, 2003 - Jan 31, 2010
NIH
Engineered Listeria monocytogenes as an AIDS vaccine
Role: Principal Investigator
U19AI056900
(LIEBERMAN, JUDY)
Aug 1, 2003 - Jan 31, 2009
NIH
RNA INTERFERENCE AS A WEAPON AGAINST BIOTERRORISM
Role: Principal Investigator
R13AI052121
(LIEBERMAN, JUDY)
Jul 1, 2002 - Jun 30, 2003
NIH
Apoptosis and Immunity
Role: Principal Investigator
R21AI047479
(LIEBERMAN, JUDY)
Jun 1, 2000 - May 31, 2002
NIH
CLINICAL STUDIES OF THERAPORE-HIV: A T CELL VACCINE
Role: Principal Investigator
R56AI045587
(LIEBERMAN, JUDY)
Jul 1, 1999 - Aug 31, 2012
NIH
Granzyme A Pathway of CTL-Mediated Cell Death
Role: Principal Investigator
R01AI045587
(LIEBERMAN, JUDY)
Jul 1, 1999 - Jun 30, 2010
NIH
Granzyme a Pathway of CTL-Mediated Cell Death
Role: Principal Investigator
R01AI045406
(LIEBERMAN, JUDY)
Feb 15, 1999 - Jan 31, 2004
NIH
PHENOTYPICALLY DEFINED CD8 T CELLS IN HIV INFECTION
Role: Principal Investigator
R01AI042519
(LIEBERMAN, JUDY)
Apr 1, 1998 - Mar 31, 2006
NIH
CD8 CELL DYSFUNCTION IN HIV INFECTION
Role: Principal Investigator
U19AI036611
(LIEBERMAN, JUDY)
Sep 1, 1994 - May 31, 1999
NIH
IMMUNE BASED THERAPY FOR HIV INFECTION
Role: Co-Principal Investigator
R01AI030926
(LIEBERMAN, JUDY)
Jul 1, 1991 - May 31, 1994
NIH
CYTOLYTIC T CELL RESPONSE TO HIV-1
Role: Principal Investigator
K08CA001449
(LIEBERMAN, JUDY)
Sep 30, 1990 - Aug 31, 1995
NIH
CYTOLYTIC MECHANISM OF T LYMPHOCYTES
Role: Principal Investigator
M01RR002172
(MANDELL, JAMES WILLIAM)
Jan 1, 1983 - Mar 31, 2009
NIH
General Clinical Research Center
Role: Co-Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Sengupta S,
Das S
, Crespo AC, Cornel AM, Patel AG,
Mahadevan NR
, Campisi M, Ali AK, Sharma B, Rowe JH, Huang H, Debruyne DN, Cerda ED,
Krajewska M
, Dries R, Chen M, Zhang S, Soriano L, Cohen MA, Versteeg R, Jaenisch R, Spranger S,
Romee R
, Miller BC,
Barbie DA
, Nierkens S,
Dyer MA
,
Lieberman J
,
George RE
. Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes. Nat Cancer. 2022 10; 3(10):1228-1246.
PMID:
36138189
.
Citations:
1
Translation:
Humans
Deng W, Bai Y, Deng F, Pan Y,
Mei S
, Zheng Z, Min R, Wu Z, Li W, Miao R, Zhang Z,
Kupper TS
,
Lieberman J
, Liu X. Author Correction: Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature. 2022 Aug; 608(7923):E28.
PMID:
35896754
.
Citations:
1
Fields:
Sci
Science
Eskandari SK,
Allos H
,
Al Dulaijan BS
, Melhem G, Sulkaj I, Alhaddad JB,
Saad AJ
, Deban C, Chu P, Choi JY, Kollar B, Pomahac B,
Riella LV
, Berger SP, Sanders JSF,
Lieberman J
, Li L,
Azzi JR
. mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis. Front Immunol. 2022; 13:899975.
PMID:
35757726
; PMCID:
PMC9229986
.
Citations:
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Sefik E, Qu R,
Junqueira C
, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez SE, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M,
Lieberman J
, Wilen CB, Kluger Y, Flavell RA. Inflammasome activation in infected macrophages drives COVID-19 pathology. Nature. 2022 06; 606(7914):585-593.
PMID:
35483404
; PMCID:
PMC9288243
.
Citations:
10
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Junqueira C
, Crespo Â,
Ranjbar S
, de Lacerda LB, Lewandrowski M, Ingber J, Parry B, Ravid S, Clark S, Schrimpf MR, Ho F, Beakes C, Margolin J, Russell N, Kays K, Boucau J,
Das Adhikari U
, Vora SM, Leger V,
Gehrke L
,
Henderson LA
, Janssen E,
Kwon D
,
Sander C
,
Abraham J
,
Goldberg MB
, Wu H, Mehta G, Bell S,
Goldfeld AE
,
Filbin MR
,
Lieberman J
. Fc?R-mediated SARS-CoV-2 infection of monocytes activates inflammation. Nature. 2022 06; 606(7914):576-584.
PMID:
35385861
.
Citations:
22
Fields:
Sci
Science
Translation:
Humans
Cells
Sefik E, Qu R,
Junqueira C
, Kaffe E, Mirza H, Zhao J, Brewer JR, Han A, Steach HR, Israelow B, Blackburn HN, Velazquez S, Chen YG, Halene S, Iwasaki A, Meffre E, Nussenzweig M,
Lieberman J
, Wilen CB, Kluger Y, Flavell RA. Inflammasome activation in infected macrophages drives COVID-19 pathology. bioRxiv. 2022 Apr 01.
PMID:
34611663
; PMCID:
PMC8491846
.
Citations:
Vora SM,
Fontana P
, Mao T, Leger V, Zhang Y, Fu TM,
Lieberman J
,
Gehrke L
, Shi M, Wang L, Iwasaki A, Wu H. Targeting stem-loop 1 of the SARS-CoV-2 5' UTR to suppress viral translation and Nsp1 evasion. Proc Natl Acad Sci U S A. 2022 03 01; 119(9).
PMID:
35149555
; PMCID:
PMC8892331
.
Citations:
5
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Deng W, Bai Y, Deng F, Pan Y,
Mei S
, Zheng Z, Min R, Wu Z, Li W, Miao R, Zhang Z,
Kupper TS
,
Lieberman J
, Liu X. Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature. 2022 02; 602(7897):496-502.
PMID:
35110732
; PMCID:
PMC9703647
.
Citations:
11
Fields:
Sci
Science
Translation:
Animals
Cells
Meza-Sosa KF,
Miao R
, Navarro F, Zhang Z, Zhang Y, Hu JJ, Hartford CCR, Li XL, Pedraza-Alva G, Pérez-MartÃnez L, Lal A, Wu H,
Lieberman J
. SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage. Mol Cell. 2022 02 17; 82(4):785-802.e10.
PMID:
35104452
.
Citations:
3
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Sen Santara S, Crespo ÂC, Mulik S, Ovies C,
Boulenouar S
, Strominger JL,
Lieberman J
. Decidual NK cells kill Zika virus-infected trophoblasts. Proc Natl Acad Sci U S A. 2021 11 23; 118(47).
PMID:
34785597
; PMCID:
PMC8617421
.
Citations:
4
Fields:
Sci
Science
Translation:
Animals
Cells
Fillmore N
, Bell S, Shen C, Nguyen V, La J, Dubreuil M,
Strymish J
,
Brophy M
, Mehta G, Wu H,
Lieberman J
, Do N, Sander C. Disulfiram use is associated with lower risk of COVID-19: A retrospective cohort study. PLoS One. 2021; 16(10):e0259061.
PMID:
34710137
.
Citations:
13
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Cells
Wang C, Yang T, Xiao J, Xu C, Alippe Y, Sun K, Kanneganti TD, Monahan JB, Abu-Amer Y,
Lieberman J
, Mbalaviele G. NLRP3 inflammasome activation triggers gasdermin D-independent inflammation. Sci Immunol. 2021 Oct 22; 6(64):eabj3859.
PMID:
34678046
; PMCID:
PMC8780201
.
Citations:
7
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Gao W, Li Y, Liu X, Wang S, Mei P, Chen Z, Liu K, Li S, Xu XW, Gan J, Wu J, Ji C, Ding C, Liu X, Lai Y, He HH,
Lieberman J
, Wu H, Chen X, Li J. TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization. Cell Death Differ. 2022 02; 29(2):439-450.
PMID:
34511601
; PMCID:
PMC8817046
.
Citations:
4
Fields:
Cel
Cell Biology
Translation:
Animals
Junqueira C
, Crespo Â,
Ranjbar S
, Lewandrowski M, Ingber J, de Lacerda LB, Parry B, Ravid S, Clark S, Ho F, Vora SM, Leger V, Beakes C, Margolin J, Russell N, Kays K,
Gehrke L
, Adhikari UD, Henderson L, Janssen E,
Kwon D
,
Sander C
, Abraham J,
Filbin M
,
Goldberg MB
, Wu H, Mehta G, Bell S,
Goldfeld AE
,
Lieberman J
. SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release. Res Sq. 2021 Aug 11.
PMID:
34401873
; PMCID:
PMC8366805
.
Citations:
Vora SM,
Lieberman J
, Wu H. Inflammasome activation at the crux of severe COVID-19. Nat Rev Immunol. 2021 11; 21(11):694-703.
PMID:
34373622
; PMCID:
PMC8351223
.
Citations:
46
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Zheng Z, Deng W, Bai Y, Miao R,
Mei S
, Zhang Z, Pan Y, Wang Y, Min R, Deng F, Wu Z, Li W, Chen P, Ma T, Lou X,
Lieberman J
, Liu X. The Lysosomal Rag-Ragulator Complex Licenses RIPK1 and Caspase-8-mediated Pyroptosis by Yersinia. Science. 2021 06 25; 372(6549).
PMID:
35058659
; PMCID:
PMC8769499
.
Citations:
12
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Hong Z, Mei J, Li C, Bai G, Maimaiti M, Hu H, Yu W, Sun L, Zhang L, Cheng D, Liao Y, Li S, You Y, Sun H, Huang J, Liu X,
Lieberman J
, Wang C. STING inhibitors target the cyclic dinucleotide binding pocket. Proc Natl Acad Sci U S A. 2021 06 15; 118(24).
PMID:
34099558
.
Citations:
7
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, Wang L, Fu TM, Jacobson MP,
Greka A
,
Lieberman J
, Ruan J, Wu H. Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature. 2021 05; 593(7860):607-611.
PMID:
33883744
; PMCID:
PMC8588876
.
Citations:
59
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Liu X, Xia S, Zhang Z, Wu H,
Lieberman J
. Channelling inflammation: gasdermins in physiology and disease. Nat Rev Drug Discov. 2021 05; 20(5):384-405.
PMID:
33692549
; PMCID:
PMC7944254
.
Citations:
55
Fields:
Dru
Drug Therapy
Pha
Pharmacology
Translation:
Humans
Animals
Junqueira C
, Crespo Â,
Ranjbar S
, Ingber J, Parry B, Ravid S, de Lacerda LB, Lewandrowski M, Clark S, Ho F, Vora SM, Leger V, Beakes C, Margolin J, Russell N,
Gehrke L
, Adhikari UD, Henderson L, Janssen E,
Kwon D
, Sander C, Abraham J,
Filbin M
,
Goldberg MB
, Wu H, Mehta G, Bell S,
Goldfeld AE
,
Lieberman J
. SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release. medRxiv. 2021 Mar 08.
PMID:
33758872
; PMCID:
PMC7987031
.
Citations:
1
Zhang Y, Xie X, Yeganeh PN,
Lee DJ
, Valle-Garcia D, Meza-Sosa KF,
Junqueira C
, Su J,
Luo HR
,
Hide W
,
Lieberman J
. Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown. Proc Natl Acad Sci U S A. 2021 03 02; 118(9).
PMID:
33627408
; PMCID:
PMC7936362
.
Citations:
5
Fields:
Sci
Science
Translation:
Humans
Animals
Junqueira C
, Polidoro RB, Castro G, Absalon S, Liang Z, Sen Santara S, Crespo Â, Pereira DB, Gazzinelli RT,
Dvorin JD
,
Lieberman J
. ?d T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis. Nat Immunol. 2021 03; 22(3):347-357.
PMID:
33432229
; PMCID:
PMC7906917
.
Citations:
18
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Zhang Z, Zhang Y,
Lieberman J
. Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity? Cancer Immunol Res. 2021 01; 9(1):2-7.
PMID:
33397791
; PMCID:
PMC7789047
.
Citations:
17
Fields:
All
Allergy and Immunology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Zhang Z,
Lieberman J
. Lighting a fire on the reef. Sci Immunol. 2020 12 04; 5(54).
PMID:
33277372
.
Citations:
2
Fields:
All
Allergy and Immunology
Translation:
Animals
Rosenblum D, Gutkin A, Kedmi R, Ramishetti S, Veiga N, Jacobi AM, Schubert MS, Friedmann-Morvinski D, Cohen ZR, Behlke MA,
Lieberman J
, Peer D. CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy. Sci Adv. 2020 11; 6(47).
PMID:
33208369
; PMCID:
PMC7673804
.
Citations:
49
Fields:
Sci
Science
Shi M, Wang L,
Fontana P
, Vora S, Zhang Y, Fu TM,
Lieberman J
, Wu H. SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism. bioRxiv. 2020 Sep 18.
PMID:
32995777
; PMCID:
PMC7523103
.
Citations:
Hojo-Souza NS, de Azevedo PO, de Castro JT, Teixeira-Carvalho A,
Lieberman J
,
Junqueira C
, Gazzinelli RT. Contributions of IFN-? and granulysin to the clearance of Plasmodium yoelii blood stage. PLoS Pathog. 2020 09; 16(9):e1008840.
PMID:
32913355
; PMCID:
PMC7482970
.
Citations:
4
Fields:
Mic
Microbiology
Translation:
Animals
Cells
Crespo ÂC, Mulik S, Dotiwala F, Ansara JA, Sen Santara S, Ingersoll K, Ovies C,
Junqueira C
, Tilburgs T, Strominger JL,
Lieberman J
. Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts. Cell. 2020 09 03; 182(5):1125-1139.e18.
PMID:
32822574
; PMCID:
PMC7484179
.
Citations:
35
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Huang L,
Deighan P
, Jin J, Li Y, Cheung HC, Lee E, Mo SS, Hoover H, Abubucker S, Finkel N, McReynolds L,
Hochschild A
,
Lieberman J
. Tombusvirus p19 Captures RNase III-Cleaved Double-Stranded RNAs Formed by Overlapping Sense and Antisense Transcripts in Escherichia coli. mBio. 2020 06 09; 11(3).
PMID:
32518184
.
Citations:
2
Fields:
Mic
Microbiology
Translation:
Cells
Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L,
Luo HR
, Kim J,
Lieberman J
, Wu H. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nat Immunol. 2020 07; 21(7):736-745.
PMID:
32367036
; PMCID:
PMC7316630
.
Citations:
140
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Zhang Z, Zhang Y, Xia S, Kong Q, Li S, Liu X,
Junqueira C
, Meza-Sosa KF, Mok TMY, Ansara J, Sengupta S, Yao Y, Wu H,
Lieberman J
. Gasdermin E suppresses tumour growth by activating anti-tumour immunity. Nature. 2020 03; 579(7799):415-420.
PMID:
32188940
.
Citations:
236
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Liu X,
Lieberman J
. Knocking 'em Dead: Pore-Forming Proteins in Immune Defense. Annu Rev Immunol. 2020 04 26; 38:455-485.
PMID:
32004099
.
Citations:
25
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S,
Hickman T
, Thomas M,
Lieberman J
, McInerney GM,
Ivanov P
,
Anderson P
. Correction: G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol. 2020 Jan 06; 219(1).
PMID:
31851327
; PMCID:
PMC7039196
.
Citations:
1
Fields:
Cel
Cell Biology
Lieberman J
, Wu H,
Kagan JC
. Gasdermin D activity in inflammation and host defense. Sci Immunol. 2019 09 06; 4(39).
PMID:
31492708
.
Citations:
42
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Dotiwala F,
Lieberman J
. Granulysin: killer lymphocyte safeguard against microbes. Curr Opin Immunol. 2019 10; 60:19-29.
PMID:
31112765
; PMCID:
PMC6800608
.
Citations:
16
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Vu LT, Peng B, Zhang DX, Ma V,
Mathey-Andrews CA
, Lam CK, Kiomourtzis T, Jin J, McReynolds L, Huang L, Grimson A, Cho WC,
Lieberman J
, Le MT. Tumor-secreted extracellular vesicles promote the activation of cancer-associated fibroblasts via the transfer of microRNA-125b. J Extracell Vesicles. 2019; 8(1):1599680.
PMID:
31044053
; PMCID:
PMC6484490
.
Citations:
37
Fields:
Bio
Biomedical Engineering
Cel
Cell Biology
Trifonova RT, Bollman B, Barteneva NS,
Lieberman J
. Myeloid Cells in Intact Human Cervical Explants Capture HIV and Can Transmit It to CD4 T Cells. Front Immunol. 2018; 9:2719.
PMID:
30532754
.
Citations:
17
Fields:
All
Allergy and Immunology
Translation:
Humans
Cells
Lieberman J
. Unveiling the RNA World. N Engl J Med. 2018 09 27; 379(13):1278-1280.
PMID:
30200806
.
Citations:
1
Fields:
Med
Medicine (General)
Translation:
Humans
Junqueira C
, Barbosa CRR, Costa PAC, Teixeira-Carvalho A, Castro G, Sen Santara S, Barbosa RP, Dotiwala F, Pereira DB, Antonelli LR,
Lieberman J
, Gazzinelli RT. Cytotoxic CD8+ T cells recognize and kill Plasmodium vivax-infected reticulocytes. Nat Med. 2018 09; 24(9):1330-1336.
PMID:
30038217
.
Citations:
31
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Meyer SE, Muench DE, Rogers AM, Newkold TJ, Orr E, O'Brien E, Perentesis JP, Doench JG, Lal A, Morris PJ, Thomas CJ,
Lieberman J
, McGlinn E, Aronow BJ, Salomonis N, Grimes HL. miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential. J Exp Med. 2018 08 06; 215(8):2115-2136.
PMID:
29997117
; PMCID:
PMC6080909
.
Citations:
9
Fields:
All
Allergy and Immunology
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Liu X, Fu R, Pan Y, Meza-Sosa KF, Zhang Z,
Lieberman J
. PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs. Cell. 2018 06 28; 174(1):187-201.e12.
PMID:
29779946
.
Citations:
24
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Ruan J, Xia S, Liu X,
Lieberman J
,
Wu H
. Cryo-EM structure of the gasdermin A3 membrane pore. Nature. 2018 05; 557(7703):62-67.
PMID:
29695864
; PMCID:
PMC6007975
.
Citations:
128
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Clayton KL
,
Collins DR
, Lengieza J,
Ghebremichael M
, Dotiwala F,
Lieberman J
,
Walker BD
. Resistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system. Nat Immunol. 2018 05; 19(5):475-486.
PMID:
29670239
; PMCID:
PMC6025741
.
Citations:
44
Fields:
All
Allergy and Immunology
Translation:
Humans
Cells
Lieberman J
. Tapping the RNA world for therapeutics. Nat Struct Mol Biol. 2018 05; 25(5):357-364.
PMID:
29662218
.
Citations:
66
Fields:
Mol
Molecular Biology
Translation:
Humans
Cells
Doan M, Vorobjev I, Rees P, Filby A, Wolkenhauer O,
Goldfeld AE
,
Lieberman J
, Barteneva N, Carpenter AE, Hennig H. Diagnostic Potential of Imaging Flow Cytometry. Trends Biotechnol. 2018 07; 36(7):649-652.
PMID:
29395345
.
Citations:
26
Fields:
Bio
Biotechnology
Translation:
Humans
Cells
Kedmi R, Veiga N, Ramishetti S, Goldsmith M, Rosenblum D, Dammes N, Hazan-Halevy I, Nahary L, Leviatan-Ben-Arye S, Harlev M, Behlke M, Benhar I,
Lieberman J
, Peer D. A modular platform for targeted RNAi therapeutics. Nat Nanotechnol. 2018 03; 13(3):214-219.
PMID:
29379205
.
Citations:
58
Fields:
Nan
Nanotechnology
Translation:
Animals
Cells
Sula Karreci E
, Eskandari SK, Dotiwala F, Routray SK, Kurdi AT,
Assaker JP
, Luckyanchykov P, Mihali AB, Maarouf O,
Borges TJ
, Alkhudhayri A, Patel KR, Radwan A,
Ghobrial I
,
McGrath M
,
Chandraker A
,
Riella LV
, Elyaman W,
Abdi R
,
Lieberman J
,
Azzi J
. Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation. JCI Insight. 2017 11 02; 2(21).
PMID:
29093262
.
Citations:
15
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
Dotiwala F, Sen Santara S, Binker-Cosen AA, Li B, Chandrasekaran S,
Lieberman J
. Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program. Cell. 2017 Nov 16; 171(5):1125-1137.e11.
PMID:
29107333
.
Citations:
29
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Chan S, Sridhar P, Kirchner R, Lock YJ,
Herbert Z
, Buonamici S, Smith P,
Lieberman J
, Petrocca F. Basal-A Triple-Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival. Mol Cancer Ther. 2017 Dec; 16(12):2849-2861.
PMID:
28878028
; PMCID:
PMC5997774
.
Citations:
20
Fields:
Ant
Antineoplastic Agents
Translation:
Humans
Cells
Deruaz M, Murooka TT, Ji S, Gavin MA, Vrbanac VD,
Lieberman J
, Tager AM,
Mempel TR
,
Luster AD
. Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa. JCI Insight. 2017 04 06; 2(7):e88533.
PMID:
28405607
.
Citations:
10
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Liu X,
Lieberman J
. A Mechanistic Understanding of Pyroptosis: The Fiery Death Triggered by Invasive Infection. Adv Immunol. 2017; 135:81-117.
PMID:
28826530
.
Citations:
57
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Su S, Liao J, Liu J, Huang D, He C, Chen F, Yang L, Wu W, Chen J, Lin L, Zeng Y, Ouyang N, Cui X, Yao H, Su F, Huang JD,
Lieberman J
, Liu Q, Song E. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res. 2017 Apr; 27(4):461-482.
PMID:
28290464
; PMCID:
PMC5385617
.
Citations:
70
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Liu X,
Lieberman J
. How ICE lights the pyroptosis fire. Cell Death Differ. 2017 02; 24(2):197-199.
PMID:
28060375
; PMCID:
PMC5299720
.
Citations:
3
Fields:
Cel
Cell Biology
Translation:
Humans
Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG,
Wu H
,
Lieberman J
. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 2016 07 07; 535(7610):153-8.
PMID:
27383986
; PMCID:
PMC5539988
.
Citations:
828
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Wheeler LA, Trifonova RT, Vrbanac V, Barteneva NS, Liu X, Bollman B, Onofrey L, Mulik S,
Ranjbar S
,
Luster AD
, Tager AM,
Lieberman J
. TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice. Cell Rep. 2016 05 24; 15(8):1715-27.
PMID:
27184854
.
Citations:
19
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Boulias K
,
Lieberman J
,
Greer EL
. An Epigenetic Clock Measures Accelerated Aging in Treated HIV Infection. Mol Cell. 2016 04 21; 62(2):153-155.
PMID:
27105110
; PMCID:
PMC5315270
.
Citations:
13
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S,
Hickman T
, Thomas M,
Lieberman J
, McInerney GM,
Ivanov P
,
Anderson P
. G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol. 2016 Mar 28; 212(7):845-60.
PMID:
27022092
; PMCID:
PMC4810302
.
Citations:
205
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Basu R, Whitlock BM, Husson J, Le Floc'h A, Jin W,
Oyler-Yaniv A
, Dotiwala F, Giannone G, Hivroz C, Biais N,
Lieberman J
, Kam LC, Huse M. Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing. Cell. 2016 Mar 24; 165(1):100-110.
PMID:
26924577
.
Citations:
128
Fields:
Cel
Cell Biology
Translation:
Animals
Cells
Dotiwala F, Mulik S, Polidoro RB, Ansara JA,
Burleigh BA
, Walch M, Gazzinelli RT,
Lieberman J
. Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites. Nat Med. 2016 Feb; 22(2):210-6.
PMID:
26752517
.
Citations:
72
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Tan SM,
Lieberman J
. Capture and Identification of miRNA Targets by Biotin Pulldown and RNA-seq. Methods Mol Biol. 2016; 1358:211-28.
PMID:
26463386
.
Citations:
21
Fields:
Mol
Molecular Biology
Weinstein S, Toker IA, Emmanuel R, Ramishetti S, Hazan-Halevy I, Rosenblum D, Goldsmith M, Abraham A, Benjamini O, Bairey O, Raanani P, Nagler A,
Lieberman J
, Peer D. Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies. Proc Natl Acad Sci U S A. 2016 Jan 05; 113(1):E16-22.
PMID:
26699502
; PMCID:
PMC4711827
.
Citations:
24
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Wittrup A,
Lieberman J
. Knocking down disease: a progress report on siRNA therapeutics. Nat Rev Genet. 2015 Sep; 16(9):543-52.
PMID:
26281785
; PMCID:
PMC4756474
.
Citations:
235
Fields:
Gen
Genetics
Translation:
Humans
Animals
Gilboa-Geffen A, Hamar P, Le MT, Wheeler LA, Trifonova R, Petrocca F, Wittrup A,
Lieberman J
. Gene Knockdown by EpCAM Aptamer-siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells. Mol Cancer Ther. 2015 Oct; 14(10):2279-91.
PMID:
26264278
.
Citations:
32
Fields:
Ant
Antineoplastic Agents
Translation:
Humans
Animals
Cells
Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M,
Kirchhausen T
,
Lieberman J
. Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown. Nat Biotechnol. 2015 Aug; 33(8):870-6.
PMID:
26192320
; PMCID:
PMC4663660
.
Citations:
146
Fields:
Bio
Biotechnology
Translation:
Humans
Cells
Navarro F,
Lieberman J
. miR-34 and p53: New Insights into a Complex Functional Relationship. PLoS One. 2015; 10(7):e0132767.
PMID:
26177460
; PMCID:
PMC4503669
.
Citations:
78
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Cells
Lieberman J
. Manipulating the in vivo immune response by targeted gene knockdown. Curr Opin Immunol. 2015 Aug; 35:63-72.
PMID:
26149459
; PMCID:
PMC4498257
.
Citations:
4
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Dotiwala F, Fellay I, Filgueira L, Martinvalet D,
Lieberman J
, Walch M. A High Yield and Cost-efficient Expression System of Human Granzymes in Mammalian Cells. J Vis Exp. 2015 Jun 10; (100):e52911.
PMID:
26132420
.
Citations:
7
Fields:
Bio
Biology
Med
Medicine (General)
Translation:
Humans
Cells
O'Day E, Le MTN, Imai S, Tan SM, Kirchner R,
Arthanari H
, Hofmann O,
Wagner G
,
Lieberman J
. An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates. J Biol Chem. 2015 Jul 17; 290(29):17909-17922.
PMID:
26045559
.
Citations:
12
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Walch M, Dotiwala F, Mulik S, Thiery J,
Kirchhausen T
, Clayberger C, Krensky AM, Martinvalet D,
Lieberman J
. Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes. Cell. 2015 May 21; 161(5):1229.
PMID:
28910642
.
Citations:
8
Fields:
Cel
Cell Biology
Thomas MP, Liu X,
Whangbo J
, McCrossan G, Sanborn KB, Basar E, Walch M,
Lieberman J
. Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2. Cell Rep. 2015 May 19; 11(7):1079-89.
PMID:
25959823
.
Citations:
57
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Sharei A, Trifonova R, Jhunjhunwala S, Hartoularos GC, Eyerman AT, Lytton-Jean A, Angin M, Sharma S, Poceviciute R, Mao S, Heimann M, Liu S, Talkar T, Khan OF, Addo M,
von Andrian UH
, Anderson DG,
Langer R
,
Lieberman J
, Jensen KF. Ex vivo cytosolic delivery of functional macromolecules to immune cells. PLoS One. 2015; 10(4):e0118803.
PMID:
25875117
.