Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

profileJudy Lieberman, M.D., PH.D.

TitleProfessor of Pediatrics
InstitutionImmune Disease Institute
DepartmentPediatrics
AddressImmune Disease Institute
Warren Alpert Building 255
200 Longwood Ave
Boston MA 02115
Phone617/713-8600
Fax617/713-8620
vCardDownload vCard (login for email)

Collapse Mentoring 
Collapse completed student projects
Synthesis of a bifunctional chimera: Discriminate delivery of siRNA to CD4+ cells by fusion to RNA-based aptamers
Summer, 01/02/07 - 08/15/07
Understanding the role of tumor-derived extracellular vesicles in breast cancer metastasis
Summer, 06/05/15 - 08/28/15

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
R21HD087689     (LIEBERMAN, JUDY)Mar 4, 2016 - Feb 28, 2018
NIH/NICHD
Control of placental infection by decidual NK cell secreted granulysin
Role: Principal Investigator
R01AI116577     (GAZZINELLI, RICARDO)Mar 1, 2016 - Feb 28, 2021
NIH/NIAID
Granzyme and Granulysin Mediated Death of Trypanosoma cruzi
Role: Co-Principal Investigator
R01AI123265     (LIEBERMAN, JUDY)Feb 15, 2016 - Jan 31, 2021
NIH/NIAID
Granulysin, Granzymes and Perforin in Bacterial Immune Defense
Role: Principal Investigator
R01CA184718     (LIEBERMAN, JUDY)Sep 24, 2015 - Aug 31, 2020
NIH/NCI
Aptamer-siRNA gene knockdown to treat epithelial triple negative breast cancer
Role: Principal Investigator
S10OD016401     (LIEBERMAN, JUDY)Jul 15, 2013 - Jul 14, 2014
NIH
IVIS Spectrum for In Vivo Imaging
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Deruaz M, Murooka TT, Ji S, Gavin MA, Vrbanac VD, Lieberman J, Tager AM, Mempel TR, Luster AD. Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa. JCI Insight. 2017 Apr 06; 2(7):e88533. PMID: 28405607.
    View in: PubMed
  2. Su S, Liao J, Liu J, Huang D, He C, Chen F, Yang L, Wu W, Chen J, Lin L, Zeng Y, Ouyang N, Cui X, Yao H, Su F, Huang JD, Lieberman J, Liu Q, Song E. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res. 2017 Apr; 27(4):461-482. PMID: 28290464.
    View in: PubMed
  3. Liu X, Lieberman J. How ICE lights the pyroptosis fire. Cell Death Differ. 2017 Feb; 24(2):197-199. PMID: 28060375.
    View in: PubMed
  4. Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 2016 07 07; 535(7610):153-8. PMID: 27383986.
    View in: PubMed
  5. Wheeler LA, Trifonova RT, Vrbanac V, Barteneva NS, Liu X, Bollman B, Onofrey L, Mulik S, Ranjbar S, Luster AD, Tager AM, Lieberman J. TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice. Cell Rep. 2016 May 24; 15(8):1715-27. PMID: 27184854; PMCID: PMC4881429.
    View in: PubMed, PubMed Central
  6. Boulias K, Lieberman J, Greer EL. An Epigenetic Clock Measures Accelerated Aging in Treated HIV Infection. Mol Cell. 2016 Apr 21; 62(2):153-5. PMID: 27105110.
    View in: PubMed
  7. Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, Thomas M, Lieberman J, McInerney GM, Ivanov P, Anderson P. G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol. 2016 Mar 28; 212(7):845-60. PMID: 27022092; PMCID: PMC4810302.
    View in: PubMed, PubMed Central
  8. Basu R, Whitlock BM, Husson J, Le Floc'h A, Jin W, Oyler-Yaniv A, Dotiwala F, Giannone G, Hivroz C, Biais N, Lieberman J, Kam LC, Huse M. Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing. Cell. 2016 Mar 24; 165(1):100-10. PMID: 26924577; PMCID: PMC4808403 [Available on 03/24/17].
    View in: PubMed, PubMed Central
  9. Dotiwala F, Mulik S, Polidoro RB, Ansara JA, Burleigh BA, Walch M, Gazzinelli RT, Lieberman J. Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites. Nat Med. 2016 Feb; 22(2):210-6. PMID: 26752517.
    View in: PubMed
  10. Tan SM, Lieberman J. Capture and Identification of miRNA Targets by Biotin Pulldown and RNA-seq. Methods Mol Biol. 2016; 1358:211-28. PMID: 26463386.
    View in: PubMed
  11. Weinstein S, Toker IA, Emmanuel R, Ramishetti S, Hazan-Halevy I, Rosenblum D, Goldsmith M, Abraham A, Benjamini O, Bairey O, Raanani P, Nagler A, Lieberman J, Peer D. Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies. Proc Natl Acad Sci U S A. 2016 Jan 05; 113(1):E16-22. PMID: 26699502; PMCID: PMC4711827.
    View in: PubMed, PubMed Central
  12. Wittrup A, Lieberman J. Knocking down disease: a progress report on siRNA therapeutics. Nat Rev Genet. 2015 Sep; 16(9):543-52. PMID: 26281785; PMCID: PMC4756474.
    View in: PubMed, PubMed Central
  13. Gilboa-Geffen A, Hamar P, Le MT, Wheeler LA, Trifonova R, Petrocca F, Wittrup A, Lieberman J. Gene Knockdown by EpCAM Aptamer-siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells. Mol Cancer Ther. 2015 Oct; 14(10):2279-91. PMID: 26264278.
    View in: PubMed
  14. Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J. Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown. Nat Biotechnol. 2015 Aug; 33(8):870-6. PMID: 26192320; PMCID: PMC4663660.
    View in: PubMed, PubMed Central
  15. Navarro F, Lieberman J. miR-34 and p53: New Insights into a Complex Functional Relationship. PLoS One. 2015; 10(7):e0132767. PMID: 26177460; PMCID: PMC4503669.
    View in: PubMed, PubMed Central
  16. Lieberman J. Manipulating the in vivo immune response by targeted gene knockdown. Curr Opin Immunol. 2015 Aug; 35:63-72. PMID: 26149459; PMCID: PMC4498257.
    View in: PubMed, PubMed Central
  17. Dotiwala F, Fellay I, Filgueira L, Martinvalet D, Lieberman J, Walch M. A High Yield and Cost-efficient Expression System of Human Granzymes in Mammalian Cells. J Vis Exp. 2015 Jun 10; (100):e52911. PMID: 26132420.
    View in: PubMed
  18. O'Day E, Le MT, Imai S, Tan SM, Kirchner R, Arthanari H, Hofmann O, Wagner G, Lieberman J. An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates. J Biol Chem. 2015 Jul 17; 290(29):17909-22. PMID: 26045559; PMCID: PMC4505039 [Available on 07/17/16].
    View in: PubMed, PubMed Central
  19. Thomas MP, Liu X, Whangbo J, McCrossan G, Sanborn KB, Basar E, Walch M, Lieberman J. Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2. Cell Rep. 2015 May 19; 11(7):1079-89. PMID: 25959823; PMCID: PMC4862650.
    View in: PubMed, PubMed Central
  20. Sharei A, Trifonova R, Jhunjhunwala S, Hartoularos GC, Eyerman AT, Lytton-Jean A, Angin M, Sharma S, Poceviciute R, Mao S, Heimann M, Liu S, Talkar T, Khan OF, Addo M, von Andrian UH, Anderson DG, Langer R, Lieberman J, Jensen KF. Ex vivo cytosolic delivery of functional macromolecules to immune cells. PLoS One. 2015; 10(4):e0118803. PMID: 25875117; PMCID: PMC4395260.
    View in: PubMed, PubMed Central
  21. Luo ML, Gong C, Chen CH, Hu H, Huang P, Zheng M, Yao Y, Wei S, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation. Cell Rep. 2015 Apr 07; 11(1):111-24. PMID: 25818297; PMCID: PMC4401741.
    View in: PubMed, PubMed Central
  22. Hata A, Lieberman J. Dysregulation of microRNA biogenesis and gene silencing in cancer. Sci Signal. 2015 Mar 17; 8(368):re3. PMID: 25783160.
    View in: PubMed
  23. Lieberman J, Sharp PA. Harnessing RNA interference for therapy: the silent treatment. JAMA. 2015 Mar 24-31; 313(12):1207-8. PMID: 25803342.
    View in: PubMed
  24. Le MT, Hamar P, Guo C, Basar E, Perdigão-Henriques R, Balaj L, Lieberman J. miR-200-containing extracellular vesicles promote breast cancer cell metastasis. J Clin Invest. 2014 Dec; 124(12):5109-28. PMID: 25401471; PMCID: PMC4348969.
    View in: PubMed, PubMed Central
  25. Ivanov P, O'Day E, Emara MM, Wagner G, Lieberman J, Anderson P. G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18201-6. PMID: 25404306; PMCID: PMC4280610.
    View in: PubMed, PubMed Central
  26. Wheeler LA, Lieberman J. Developing an Effective Rectal Microbicide: Inhibiting HIV Transmission in Human Colorectal Tissue and Humanized Mice with CD4 Aptamer-siRNA Chimeras. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A206. PMID: 25357578.
    View in: PubMed
  27. Wheeler LA, Lieberman J. Inhibiting the Host Exonuclease TREX1 Induces a Localized and Protective Host Interferon Response against Acute HIV Infection In Vivo. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A41. PMID: 25357849.
    View in: PubMed
  28. Tan SM, Kirchner R, Jin J, Hofmann O, McReynolds L, Hide W, Lieberman J. Sequencing of captive target transcripts identifies the network of regulated genes and functions of primate-specific miR-522. Cell Rep. 2014 Aug 21; 8(4):1225-39. PMID: 25131211.
    View in: PubMed
  29. Tay Y, Tan SM, Karreth FA, Lieberman J, Pandolfi PP. Characterization of dual PTEN and p53-targeting microRNAs identifies microRNA-638/Dnm2 as a two-hit oncogenic locus. Cell Rep. 2014 Aug 07; 8(3):714-22. PMID: 25088422; PMCID: PMC4128194.
    View in: PubMed, PubMed Central
  30. Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J. Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes. Cell. 2014 Jun 05; 157(6):1309-23. PMID: 24906149; PMCID: PMC4090916.
    View in: PubMed, PubMed Central
  31. Luo ML, Gong C, Chen CH, Lee DY, Hu H, Huang P, Yao Y, Guo W, Reinhardt F, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer. Cancer Res. 2014 Jul 01; 74(13):3603-16. PMID: 24786790; PMCID: PMC4079726.
    View in: PubMed, PubMed Central
  32. Thomas MP, Whangbo J, McCrossan G, Deutsch AJ, Martinod K, Walch M, Lieberman J. Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins. J Immunol. 2014 Jun 01; 192(11):5390-7. PMID: 24771851; PMCID: PMC4041364.
    View in: PubMed, PubMed Central
  33. Trifonova RT, Lieberman J, van Baarle D. Distribution of immune cells in the human cervix and implications for HIV transmission. Am J Reprod Immunol. 2014 Mar; 71(3):252-64. PMID: 24410939; PMCID: PMC3943534.
    View in: PubMed, PubMed Central
  34. Thiery J, Lieberman J. Perforin: a key pore-forming protein for immune control of viruses and cancer. Subcell Biochem. 2014; 80:197-220. PMID: 24798013.
    View in: PubMed
  35. Huang L, Lieberman J. Production of highly potent recombinant siRNAs in Escherichia coli. Nat Protoc. 2013 Dec; 8(12):2325-36. PMID: 24177290.
    View in: PubMed
  36. Tuli A, Thiery J, James AM, Michelet X, Sharma M, Garg S, Sanborn KB, Orange JS, Lieberman J, Brenner MB. Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. Mol Biol Cell. 2013 Dec; 24(23):3721-35. PMID: 24088571; PMCID: PMC3842998.
    View in: PubMed, PubMed Central
  37. Petrocca F, Altschuler G, Tan SM, Mendillo ML, Yan H, Jerry DJ, Kung AL, Hide W, Ince TA, Lieberman J. A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells. Cancer Cell. 2013 Aug 12; 24(2):182-96. PMID: 23948298; PMCID: PMC3773329.
    View in: PubMed, PubMed Central
  38. Thomas MP, Lieberman J. Live or let die: posttranscriptional gene regulation in cell stress and cell death. Immunol Rev. 2013 May; 253(1):237-52. PMID: 23550650.
    View in: PubMed
  39. Wheeler LA, Vrbanac V, Trifonova R, Brehm MA, Gilboa-Geffen A, Tanno S, Greiner DL, Luster AD, Tager AM, Lieberman J. Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras. Mol Ther. 2013 Jul; 21(7):1378-89. PMID: 23629001; PMCID: PMC3702101.
    View in: PubMed, PubMed Central
  40. Lieberman J, Slack F, Pandolfi PP, Chinnaiyan A, Agami R, Mendell JT. Noncoding RNAs and cancer. Cell. 2013 Mar 28; 153(1):9-10. PMID: 23781554.
    View in: PubMed
  41. Huang L, Jin J, Deighan P, Kiner E, McReynolds L, Lieberman J. Efficient and specific gene knockdown by small interfering RNAs produced in bacteria. Nat Biotechnol. 2013 Apr; 31(4):350-6. PMID: 23475073; PMCID: PMC3622153.
    View in: PubMed, PubMed Central
  42. Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N. Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nat Immunol. 2013 Feb; 14(2):179-85. PMID: 23263557; PMCID: PMC3838897.
    View in: PubMed, PubMed Central
  43. Yan N, Lieberman J. SAMHD1 does it again, now in resting T cells. Nat Med. 2012 Nov; 18(11):1611-2. PMID: 23135508; PMCID: PMC4036678.
    View in: PubMed, PubMed Central
  44. Rajani DK, Walch M, Martinvalet D, Thomas MP, Lieberman J. Alterations in RNA processing during immune-mediated programmed cell death. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8688-93. PMID: 22589304; PMCID: PMC3365155.
    View in: PubMed, PubMed Central
  45. Yao YD, Sun TM, Huang SY, Dou S, Lin L, Chen JN, Ruan JB, Mao CQ, Yu FY, Zeng MS, Zang JY, Liu Q, Su FX, Zhang P, Lieberman J, Wang J, Song E. Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis. Sci Transl Med. 2012 Apr 18; 4(130):130ra48. PMID: 22517885.
    View in: PubMed
  46. Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A. Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem. 2012 Feb 03; 287(6):3976-86. PMID: 22158624; PMCID: PMC3281737.
    View in: PubMed, PubMed Central
  47. Lal A, Thomas MP, Altschuler G, Navarro F, O'Day E, Li XL, Concepcion C, Han YC, Thiery J, Rajani DK, Deutsch A, Hofmann O, Ventura A, Hide W, Lieberman J. Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet. 2011 Nov; 7(11):e1002363. PMID: 22102825; PMCID: PMC3213160.
    View in: PubMed, PubMed Central
  48. Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L, Provero P, Di Cunto F, Lieberman J, Rigoutsos I, Pandolfi PP. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell. 2011 Oct 14; 147(2):344-57. PMID: 22000013; PMCID: PMC3235920.
    View in: PubMed, PubMed Central
  49. Le MT, Shyh-Chang N, Khaw SL, Chin L, Teh C, Tay J, O'Day E, Korzh V, Yang H, Lal A, Lieberman J, Lodish HF, Lim B. Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet. 2011 Sep; 7(9):e1002242. PMID: 21935352; PMCID: PMC3174204.
    View in: PubMed, PubMed Central
  50. Lakhashe SK, Velu V, Sciaranghella G, Siddappa NB, Dipasquale JM, Hemashettar G, Yoon JK, Rasmussen RA, Yang F, Lee SJ, Montefiori DC, Novembre FJ, Villinger F, Amara RR, Kahn M, Hu SL, Li S, Li Z, Frankel FR, Robert-Guroff M, Johnson WE, Lieberman J, Ruprecht RM. Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges. Vaccine. 2011 Aug 05; 29(34):5611-22. PMID: 21693155; PMCID: PMC3154722.
    View in: PubMed, PubMed Central
  51. Thiery J, Keefe D, Boulant S, Boucrot E, Walch M, Martinvalet D, Goping IS, Bleackley RC, Kirchhausen T, Lieberman J. Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat Immunol. 2011 Jun 19; 12(8):770-7. PMID: 21685908; PMCID: PMC3140544.
    View in: PubMed, PubMed Central
  52. Wheeler LA, Trifonova R, Vrbanac V, Basar E, McKernan S, Xu Z, Seung E, Deruaz M, Dudek T, Einarsson JI, Yang L, Allen TM, Luster AD, Tager AM, Dykxhoorn DM, Lieberman J. Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. J Clin Invest. 2011 Jun; 121(6):2401-12. PMID: 21576818; PMCID: PMC3104760.
    View in: PubMed, PubMed Central
  53. Yan N, O'Day E, Wheeler LA, Engelman A, Lieberman J. HIV DNA is heavily uracilated, which protects it from autointegration. Proc Natl Acad Sci U S A. 2011 May 31; 108(22):9244-9. PMID: 21576478; PMCID: PMC3107311.
    View in: PubMed, PubMed Central
  54. Whitney JB, Mirshahidi S, Lim SY, Goins L, Ibegbu CC, Anderson DC, Raybourne RB, Frankel FR, Lieberman J, Ruprecht RM. Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV. J Immune Based Ther Vaccines. 2011 Jan 18; 9:2. PMID: 21244649; PMCID: PMC3033796.
    View in: PubMed, PubMed Central
  55. Yan N, Lieberman J. Gaining a foothold: how HIV avoids innate immune recognition. Curr Opin Immunol. 2011 Feb; 23(1):21-8. PMID: 21123040; PMCID: PMC3042516.
    View in: PubMed, PubMed Central
  56. Petrocca F, Lieberman J. Promise and challenge of RNA interference-based therapy for cancer. J Clin Oncol. 2011 Feb 20; 29(6):747-54. PMID: 21079135.
    View in: PubMed
  57. Thomas M, Lieberman J, Lal A. Desperately seeking microRNA targets. Nat Struct Mol Biol. 2010 Oct; 17(10):1169-74. PMID: 20924405.
    View in: PubMed
  58. Yan N, Regalado-Magdos AD, Stiggelbout B, Lee-Kirsch MA, Lieberman J. The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol. 2010 Nov; 11(11):1005-13. PMID: 20871604; PMCID: PMC2958248.
    View in: PubMed, PubMed Central
  59. Navarro F, Lieberman J. Small RNAs guide hematopoietic cell differentiation and function. J Immunol. 2010 Jun 01; 184(11):5939-47. PMID: 20483778.
    View in: PubMed
  60. Thiery J, Walch M, Jensen DK, Martinvalet D, Lieberman J. Isolation of cytotoxic T cell and NK granules and purification of their effector proteins. Curr Protoc Cell Biol. 2010 Jun; Chapter 3:Unit3.37. PMID: 20521234.
    View in: PubMed
  61. Lieberman J. Anatomy of a murder: how cytotoxic T cells and NK cells are activated, develop, and eliminate their targets. Immunol Rev. 2010 May; 235(1):5-9. PMID: 20536551.
    View in: PubMed
  62. Lieberman J. Granzyme A activates another way to die. Immunol Rev. 2010 May; 235(1):93-104. PMID: 20536557; PMCID: PMC2905780.
    View in: PubMed, PubMed Central
  63. Niland B, Miklossy G, Banki K, Biddison WE, Casciola-Rosen L, Rosen A, Martinvalet D, Lieberman J, Perl A. Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients. J Immunol. 2010 Apr 01; 184(7):4025-32. PMID: 20194725; PMCID: PMC3117466.
    View in: PubMed, PubMed Central
  64. Thiery J, Keefe D, Saffarian S, Martinvalet D, Walch M, Boucrot E, Kirchhausen T, Lieberman J. Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis. Blood. 2010 Feb 25; 115(8):1582-93. PMID: 20038786; PMCID: PMC2830763.
    View in: PubMed, PubMed Central
  65. Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A. Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J. 2010 Feb 03; 29(3):559-73. PMID: 20019669; PMCID: PMC2830697.
    View in: PubMed, PubMed Central
  66. Lieberman J. Micromanaging cancer. N Engl J Med. 2009 Oct 08; 361(15):1500-1. PMID: 19812408.
    View in: PubMed
  67. Dykxhoorn DM, Wu Y, Xie H, Yu F, Lal A, Petrocca F, Martinvalet D, Song E, Lim B, Lieberman J. miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS One. 2009 Sep 29; 4(9):e7181. PMID: 19787069; PMCID: PMC2749331.
    View in: PubMed, PubMed Central
  68. Lal A, Navarro F, Maher CA, Maliszewski LE, Yan N, O'Day E, Chowdhury D, Dykxhoorn DM, Tsai P, Hofmann O, Becker KG, Gorospe M, Hide W, Lieberman J. miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell. 2009 Sep 11; 35(5):610-25. PMID: 19748357; PMCID: PMC2757794.
    View in: PubMed, PubMed Central
  69. Petrocca F, Lieberman J. Micromanipulating cancer: microRNA-based therapeutics? RNA Biol. 2009 Jul-Aug; 6(3):335-40. PMID: 19535911.
    View in: PubMed
  70. Navarro F, Gutman D, Meire E, Cáceres M, Rigoutsos I, Bentwich Z, Lieberman J. miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53. Blood. 2009 Sep 03; 114(10):2181-92. PMID: 19584398.
    View in: PubMed
  71. Ahmed F, Friend S, George TC, Barteneva N, Lieberman J. Numbers matter: quantitative and dynamic analysis of the formation of an immunological synapse using imaging flow cytometry. J Immunol Methods. 2009 Aug 15; 347(1-2):79-86. PMID: 19524586; PMCID: PMC2752738.
    View in: PubMed, PubMed Central
  72. Zhu P, Martinvalet D, Chowdhury D, Zhang D, Schlesinger A, Lieberman J. The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1. Blood. 2009 Aug 06; 114(6):1205-16. PMID: 19506301; PMCID: PMC2723016.
    View in: PubMed, PubMed Central
  73. Glimcher LH, Lieberman J. Harvard's women four years later. Nat Immunol. 2009 Jun; 10(6):559-61. PMID: 19448653.
    View in: PubMed
  74. Lal A, Pan Y, Navarro F, Dykxhoorn DM, Moreau L, Meire E, Bentwich Z, Lieberman J, Chowdhury D. miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells. Nat Struct Mol Biol. 2009 May; 16(5):492-8. PMID: 19377482; PMCID: PMC2853019.
    View in: PubMed, PubMed Central
  75. Yan N, Cherepanov P, Daigle JE, Engelman A, Lieberman J. The SET complex acts as a barrier to autointegration of HIV-1. PLoS Pathog. 2009 Mar; 5(3):e1000327. PMID: 19266025; PMCID: PMC2644782.
    View in: PubMed, PubMed Central
  76. Wu Y, Navarro F, Lal A, Basar E, Pandey RK, Manoharan M, Feng Y, Lee SJ, Lieberman J, Palliser D. Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene. Cell Host Microbe. 2009 Jan 22; 5(1):84-94. PMID: 19154990; PMCID: PMC2654264.
    View in: PubMed, PubMed Central
  77. Petrocca F, Lieberman J. Micromanagers of immune cell fate and function. Adv Immunol. 2009; 102:227-44. PMID: 19477322.
    View in: PubMed
  78. Petrocca F, Lieberman J. RIG-ing an antitumor response. Nat Med. 2008 Nov; 14(11):1152-3. PMID: 18989278.
    View in: PubMed
  79. Shun MC, Botbol Y, Li X, Di Nunzio F, Daigle JE, Yan N, Lieberman J, Lavigne M, Engelman A. Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity. J Virol. 2008 Dec; 82(23):11555-67. PMID: 18799576; PMCID: PMC2583668.
    View in: PubMed, PubMed Central
  80. Grant RM, Hamer D, Hope T, Johnston R, Lange J, Lederman MM, Lieberman J, Miller CJ, Moore JP, Mosier DE, Richman DD, Schooley RT, Springer MS, Veazey RS, Wainberg MA. Whither or wither microbicides? Science. 2008 Jul 25; 321(5888):532-4. PMID: 18653884; PMCID: PMC2835691.
    View in: PubMed, PubMed Central
  81. Chowdhury D, Xu X, Zhong X, Ahmed F, Zhong J, Liao J, Dykxhoorn DM, Weinstock DM, Pfeifer GP, Lieberman J. A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Mol Cell. 2008 Jul 11; 31(1):33-46. PMID: 18614045; PMCID: PMC3242369.
    View in: PubMed, PubMed Central
  82. Martinvalet D, Dykxhoorn DM, Ferrini R, Lieberman J. Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death. Cell. 2008 May 16; 133(4):681-92. PMID: 18485875; PMCID: PMC2840390.
    View in: PubMed, PubMed Central
  83. Lal A, Kim HH, Abdelmohsen K, Kuwano Y, Pullmann R, Srikantan S, Subrahmanyam R, Martindale JL, Yang X, Ahmed F, Navarro F, Dykxhoorn D, Lieberman J, Gorospe M. p16(INK4a) translation suppressed by miR-24. PLoS One. 2008 Mar 26; 3(3):e1864. PMID: 18365017; PMCID: PMC2274865.
    View in: PubMed, PubMed Central
  84. Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ. Identification of host proteins required for HIV infection through a functional genomic screen. Science. 2008 Feb 15; 319(5865):921-6. PMID: 18187620.
    View in: PubMed
  85. Chowdhury D, Lieberman J. Death by a thousand cuts: granzyme pathways of programmed cell death. Annu Rev Immunol. 2008; 26:389-420. PMID: 18304003; PMCID: PMC2790083.
    View in: PubMed, PubMed Central
  86. Dykxhoorn DM, Chowdhury D, Lieberman J. RNA interference and cancer: endogenous pathways and therapeutic approaches. Adv Exp Med Biol. 2008; 615:299-329. PMID: 18437900.
    View in: PubMed
  87. Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, Huang Y, Hu X, Su F, Lieberman J, Song E. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell. 2007 Dec 14; 131(6):1109-23. PMID: 18083101.
    View in: PubMed
  88. Jiang S, Rasmussen RA, Nolan KM, Frankel FR, Lieberman J, McClure HM, Williams KM, Babu US, Raybourne RB, Strobert E, Ruprecht RM. Live attenuated Listeria monocytogenes expressing HIV Gag: immunogenicity in rhesus monkeys. Vaccine. 2007 Oct 16; 25(42):7470-9. PMID: 17854955; PMCID: PMC2518091.
    View in: PubMed, PubMed Central
  89. Lee-Kirsch MA, Gong M, Chowdhury D, Senenko L, Engel K, Lee YA, de Silva U, Bailey SL, Witte T, Vyse TJ, Kere J, Pfeiffer C, Harvey S, Wong A, Koskenmies S, Hummel O, Rohde K, Schmidt RE, Dominiczak AF, Gahr M, Hollis T, Perrino FW, Lieberman J, Hübner N. Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet. 2007 Sep; 39(9):1065-7. PMID: 17660818.
    View in: PubMed
  90. de Fougerolles A, Vornlocher HP, Maraganore J, Lieberman J. Interfering with disease: a progress report on siRNA-based therapeutics. Nat Rev Drug Discov. 2007 Jun; 6(6):443-53. PMID: 17541417.
    View in: PubMed
  91. Lee-Kirsch MA, Chowdhury D, Harvey S, Gong M, Senenko L, Engel K, Pfeiffer C, Hollis T, Gahr M, Perrino FW, Lieberman J, Hubner N. A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus. J Mol Med (Berl). 2007 May; 85(5):531-7. PMID: 17440703.
    View in: PubMed
  92. Pipkin ME, Lieberman J. Delivering the kiss of death: progress on understanding how perforin works. Curr Opin Immunol. 2007 Jun; 19(3):301-8. PMID: 17433871.
    View in: PubMed
  93. Peer D, Zhu P, Carman CV, Lieberman J, Shimaoka M. Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):4095-100. PMID: 17360483; PMCID: PMC1820714.
    View in: PubMed, PubMed Central
  94. Ranjbar S, Tsytsykova AV, Lee SK, Rajsbaum R, Falvo JV, Lieberman J, Shankar P, Goldfeld AE. NFAT5 regulates HIV-1 in primary monocytes via a highly conserved long terminal repeat site. PLoS Pathog. 2006 Dec; 2(12):e130. PMID: 17173480; PMCID: PMC1698943.
    View in: PubMed, PubMed Central
  95. Dykxhoorn DM, Lieberman J. Knocking down disease with siRNAs. Cell. 2006 Jul 28; 126(2):231-5. PMID: 16873051.
    View in: PubMed
  96. Dykxhoorn DM, Lieberman J. Silencing viral infection. PLoS Med. 2006 Jul; 3(7):e242. PMID: 16848617; PMCID: PMC1518680.
    View in: PubMed, PubMed Central
  97. Chowdhury D, Beresford PJ, Zhu P, Zhang D, Sung JS, Demple B, Perrino FW, Lieberman J. The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Mol Cell. 2006 Jul 07; 23(1):133-42. PMID: 16818237.
    View in: PubMed
  98. Dykxhoorn DM, Schlehuber LD, London IM, Lieberman J. Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5953-8. PMID: 16585504; PMCID: PMC1458679.
    View in: PubMed, PubMed Central
  99. Dykxhoorn DM, Palliser D, Lieberman J. The silent treatment: siRNAs as small molecule drugs. Gene Ther. 2006 Mar; 13(6):541-52. PMID: 16397510.
    View in: PubMed
  100. Zhu P, Zhang D, Chowdhury D, Martinvalet D, Keefe D, Shi L, Lieberman J. Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70. EMBO Rep. 2006 Apr; 7(4):431-7. PMID: 16440001; PMCID: PMC1456912.
    View in: PubMed, PubMed Central
  101. Dykxhoorn DM, Lieberman J. Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs. Annu Rev Biomed Eng. 2006; 8:377-402. PMID: 16834561.
    View in: PubMed
  102. Chowdhury D, Keogh MC, Ishii H, Peterson CL, Buratowski S, Lieberman J. gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell. 2005 Dec 09; 20(5):801-9. PMID: 16310392.
    View in: PubMed
  103. Palliser D, Chowdhury D, Wang QY, Lee SJ, Bronson RT, Knipe DM, Lieberman J. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature. 2006 Jan 05; 439(7072):89-94. PMID: 16306938.
    View in: PubMed
  104. Keogh MC, Kim JA, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, Greenblatt JF, Krogan NJ. A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature. 2006 Jan 26; 439(7075):497-501. PMID: 16299494.
    View in: PubMed
  105. Keefe D, Shi L, Feske S, Massol R, Navarro F, Kirchhausen T, Lieberman J. Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. Immunity. 2005 Sep; 23(3):249-62. PMID: 16169498.
    View in: PubMed
  106. Feng H, Zhang D, Palliser D, Zhu P, Cai S, Schlesinger A, Maliszewski L, Lieberman J. Listeria-infected myeloid dendritic cells produce IFN-beta, priming T cell activation. J Immunol. 2005 Jul 01; 175(1):421-32. PMID: 15972676.
    View in: PubMed
  107. Liu L, Xu Z, Fuhlbrigge RC, Peña-Cruz V, Lieberman J, Kupper TS. Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion. J Virol. 2005 Jun; 79(12):7363-70. PMID: 15919891; PMCID: PMC1143660.
    View in: PubMed, PubMed Central
  108. Song E, Zhu P, Lee SK, Chowdhury D, Kussman S, Dykxhoorn DM, Feng Y, Palliser D, Weiner DB, Shankar P, Marasco WA, Lieberman J. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol. 2005 Jun; 23(6):709-17. PMID: 15908939.
    View in: PubMed
  109. Shi L, Keefe D, Durand E, Feng H, Zhang D, Lieberman J. Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis. J Immunol. 2005 May 01; 174(9):5456-61. PMID: 15843543.
    View in: PubMed
  110. Lee SK, Dykxhoorn DM, Kumar P, Ranjbar S, Song E, Maliszewski LE, François-Bongarçon V, Goldfeld A, Swamy NM, Lieberman J, Shankar P. Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV. Blood. 2005 Aug 01; 106(3):818-26. PMID: 15831707; PMCID: PMC1895148.
    View in: PubMed, PubMed Central
  111. Shankar P, Manjunath N, Lieberman J. The prospect of silencing disease using RNA interference. JAMA. 2005 Mar 16; 293(11):1367-73. PMID: 15769970.
    View in: PubMed
  112. Martinvalet D, Zhu P, Lieberman J. Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis. Immunity. 2005 Mar; 22(3):355-70. PMID: 15780992.
    View in: PubMed
  113. Xue Y, Johnson JS, Ornelles DA, Lieberman J, Engel DA. Adenovirus protein VII functions throughout early phase and interacts with cellular proteins SET and pp32. J Virol. 2005 Feb; 79(4):2474-83. PMID: 15681448; PMCID: PMC546597.
    View in: PubMed, PubMed Central
  114. Dykxhoorn DM, Lieberman J. The silent revolution: RNA interference as basic biology, research tool, and therapeutic. Annu Rev Med. 2005; 56:401-23. PMID: 15660519.
    View in: PubMed
  115. François-Bongarcon V, Feng Y, Lee SK, Chen G, Shankar P, Liu Y, Tao X, Shao Y, Lieberman J. Cross-clade CD8 T-cell responses to HIV(IIIB) and Chinese B' and C/B' viruses in North American and Chinese HIV-seropositive donors. J Acquir Immune Defic Syndr. 2004 Dec 01; 37(4):1435-44. PMID: 15602120.
    View in: PubMed
  116. Hamar P, Song E, Kökény G, Chen A, Ouyang N, Lieberman J. Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14883-8. PMID: 15466709; PMCID: PMC522049.
    View in: PubMed, PubMed Central
  117. Ince MN, Harnisch B, Xu Z, Lee SK, Lange C, Moretta L, Lederman M, Lieberman J. Increased expression of the natural killer cell inhibitory receptor CD85j/ILT2 on antigen-specific effector CD8 T cells and its impact on CD8 T-cell function. Immunology. 2004 Aug; 112(4):531-42. PMID: 15270723; PMCID: PMC1782522.
    View in: PubMed, PubMed Central
  118. Lieberman J. Tracking the killers: how should we measure CD8 T cells in HIV infection? AIDS. 2004 Jul 23; 18(11):1489-93. PMID: 15238766.
    View in: PubMed
  119. Lange CG, Xu Z, Patterson BK, Medvik K, Harnisch B, Asaad R, Valdez H, Lee SJ, Landay A, Lieberman J, Lederman MM. Proliferation responses to HIVp24 during antiretroviral therapy do not reflect improved immune phenotype or function. AIDS. 2004 Mar 05; 18(4):605-13. PMID: 15090765.
    View in: PubMed
  120. Burton DR, Desrosiers RC, Doms RW, Feinberg MB, Gallo RC, Hahn B, Hoxie JA, Hunter E, Korber B, Landay A, Lederman MM, Lieberman J, McCune JM, Moore JP, Nathanson N, Picker L, Richman D, Rinaldo C, Stevenson M, Watkins DI, Wolinsky SM, Zack JA. Public health. A sound rationale needed for phase III HIV-1 vaccine trials. Science. 2004 Jan 16; 303(5656):316. PMID: 14726576.
    View in: PubMed
  121. Lieberman J, Fan Z. Nuclear war: the granzyme A-bomb. Curr Opin Immunol. 2003 Oct; 15(5):553-9. PMID: 14499264.
    View in: PubMed
  122. De Groot AS, Jesdale B, Martin W, Saint Aubin C, Sbai H, Bosma A, Lieberman J, Skowron G, Mansourati F, Mayer KH. Mapping cross-clade HIV-1 vaccine epitopes using a bioinformatics approach. Vaccine. 2003 Oct 01; 21(27-30):4486-504. PMID: 14505932.
    View in: PubMed
  123. Wan J, Martinvalet D, Ji X, Lois C, Kaech SM, Von Andrian UH, Lieberman J, Ahmed R, Manjunath N. The Bcl-2 family pro-apoptotic molecule, BNIP3 regulates activation-induced cell death of effector cytotoxic T lymphocytes. Immunology. 2003 Sep; 110(1):10-7. PMID: 12941136; PMCID: PMC1783016.
    View in: PubMed, PubMed Central
  124. Lieberman J, Song E, Lee SK, Shankar P. Interfering with disease: opportunities and roadblocks to harnessing RNA interference. Trends Mol Med. 2003 Sep; 9(9):397-403. PMID: 13129706.
    View in: PubMed
  125. Song E, Lee SK, Dykxhoorn DM, Novina C, Zhang D, Crawford K, Cerny J, Sharp PA, Lieberman J, Manjunath N, Shankar P. Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages. J Virol. 2003 Jul; 77(13):7174-81. PMID: 12805416; PMCID: PMC164789.
    View in: PubMed, PubMed Central
  126. Kushner N, Zhang D, Touzjian N, Essex M, Lieberman J, Lu Y. A fragment of anthrax lethal factor delivers proteins to the cytosol without requiring protective antigen. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6652-7. PMID: 12740437; PMCID: PMC164502.
    View in: PubMed, PubMed Central
  127. Lieberman J. The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. Nat Rev Immunol. 2003 May; 3(5):361-70. PMID: 12766758.
    View in: PubMed
  128. Gu X, Laouar A, Wan J, Daheshia M, Lieberman J, Yokoyama WM, Katz HR, Manjunath N. The gp49B1 inhibitory receptor regulates the IFN-gamma responses of T cells and NK cells. J Immunol. 2003 Apr 15; 170(8):4095-101. PMID: 12682239.
    View in: PubMed
  129. Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell. 2003 Mar 07; 112(5):659-72. PMID: 12628186.
    View in: PubMed
  130. Song E, Lee SK, Wang J, Ince N, Ouyang N, Min J, Chen J, Shankar P, Lieberman J. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med. 2003 Mar; 9(3):347-51. PMID: 12579197.
    View in: PubMed
  131. Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J. Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nat Immunol. 2003 Feb; 4(2):145-53. PMID: 12524539.
    View in: PubMed
  132. Geiben-Lynn R, Kursar M, Brown NV, Addo MM, Shau H, Lieberman J, Luster AD, Walker BD. HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family. J Biol Chem. 2003 Jan 17; 278(3):1569-74. PMID: 12421812.
    View in: PubMed
  133. Lee SK, Xu Z, Lieberman J, Shankar P. The functional CD8 T cell response to HIV becomes type-specific in progressive disease. J Clin Invest. 2002 Nov; 110(9):1339-47. PMID: 12417573; PMCID: PMC151615.
    View in: PubMed, PubMed Central
  134. Lieberman J. Defying death--HIV mutation to evade cytotoxic T lymphocytes. N Engl J Med. 2002 Oct 10; 347(15):1203-4. PMID: 12374884.
    View in: PubMed
  135. Zhang D, Shankar P, Xu Z, Harnisch B, Chen G, Lange C, Lee SJ, Valdez H, Lederman MM, Lieberman J. Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic. Blood. 2003 Jan 01; 101(1):226-35. PMID: 12393740.
    View in: PubMed
  136. Lieberman J, Manjunath N, Shankar P. Avoiding the kiss of death: how HIV and other chronic viruses survive. Curr Opin Immunol. 2002 Aug; 14(4):478-86. PMID: 12088683.
    View in: PubMed
  137. Novina CD, Murray MF, Dykxhoorn DM, Beresford PJ, Riess J, Lee SK, Collman RG, Lieberman J, Shankar P, Sharp PA. siRNA-directed inhibition of HIV-1 infection. Nat Med. 2002 Jul; 8(7):681-6. PMID: 12042777.
    View in: PubMed
  138. Lieberman J, Frankel FR. Engineered Listeria monocytogenes as an AIDS vaccine. Vaccine. 2002 May 06; 20(15):2007-10. PMID: 11983264.
    View in: PubMed
  139. Fan Z, Beresford PJ, Zhang D, Lieberman J. HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Mol Cell Biol. 2002 Apr; 22(8):2810-20. PMID: 11909973; PMCID: PMC133744.
    View in: PubMed, PubMed Central
  140. Lieberman J, Shankar P, Manjunath N, Andersson J. Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection. Blood. 2001 Sep 15; 98(6):1667-77. PMID: 11535496.
    View in: PubMed
  141. Beresford PJ, Zhang D, Oh DY, Fan Z, Greer EL, Russo ML, Jaju M, Lieberman J. Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks. J Biol Chem. 2001 Nov 16; 276(46):43285-93. PMID: 11555662.
    View in: PubMed
  142. Manjunath N, Shankar P, Wan J, Weninger W, Crowley MA, Hieshima K, Springer TA, Fan X, Shen H, Lieberman J, von Andrian UH. Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. J Clin Invest. 2001 Sep; 108(6):871-8. PMID: 11560956; PMCID: PMC200936.
    View in: PubMed, PubMed Central
  143. Chen G, Shankar P, Lange C, Valdez H, Skolnik PR, Wu L, Manjunath N, Lieberman J. CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection. Blood. 2001 Jul 01; 98(1):156-64. PMID: 11418475.
    View in: PubMed
  144. Sharif-Askari E, Alam A, Rhéaume E, Beresford PJ, Scotto C, Sharma K, Lee D, DeWolf WE, Nuttall ME, Lieberman J, Sékaly RP. Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation. EMBO J. 2001 Jun 15; 20(12):3101-13. PMID: 11406587; PMCID: PMC150191.
    View in: PubMed, PubMed Central
  145. Zhang D, Beresford PJ, Greenberg AH, Lieberman J. Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5746-51. PMID: 11331782; PMCID: PMC33284.
    View in: PubMed, PubMed Central
  146. Shankar P, Russo M, Harnisch B, Patterson M, Skolnik P, Lieberman J. Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection. Blood. 2000 Nov 01; 96(9):3094-101. PMID: 11049989.
    View in: PubMed
  147. Zhang D, Pasternack MS, Beresford PJ, Wagner L, Greenberg AH, Lieberman J. Induction of rapid histone degradation by the cytotoxic T lymphocyte protease Granzyme A. J Biol Chem. 2001 Feb 02; 276(5):3683-90. PMID: 11060286.
    View in: PubMed
  148. Friedman RS, Frankel FR, Xu Z, Lieberman J. Induction of human immunodeficiency virus (HIV)-specific CD8 T-cell responses by Listeria monocytogenes and a hyperattenuated Listeria strain engineered to express HIV antigens. J Virol. 2000 Nov; 74(21):9987-93. PMID: 11024127; PMCID: PMC102037.
    View in: PubMed, PubMed Central
  149. Kadry Z, Roux-Lombard P, Dayer JM, Lieberman J, Marks WH, Dafoe D, Cretin N, Cighetti G, Buhler L, Charbonnet P, Morel P. Impact of intestinal ischemia-reperfusion on cytokine profile and enterocyte viability in human syngeneic intestinal transplantation. Transplant Proc. 2000 Sep; 32(6):1292-3. PMID: 10995953.
    View in: PubMed
  150. Trimble LA, Kam LW, Friedman RS, Xu Z, Lieberman J. CD3zeta and CD28 down-modulation on CD8 T cells during viral infection. Blood. 2000 Aug 01; 96(3):1021-9. PMID: 10910918.
    View in: PubMed
  151. Trimble LA, Shankar P, Patterson M, Daily JP, Lieberman J. Human immunodeficiency virus-specific circulating CD8 T lymphocytes have down-modulated CD3zeta and CD28, key signaling molecules for T-cell activation. J Virol. 2000 Aug; 74(16):7320-30. PMID: 10906185; PMCID: PMC112252.
    View in: PubMed, PubMed Central
  152. Lu Y, Friedman R, Kushner N, Doling A, Thomas L, Touzjian N, Starnbach M, Lieberman J. Genetically modified anthrax lethal toxin safely delivers whole HIV protein antigens into the cytosol to induce T cell immunity. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):8027-32. PMID: 10884430; PMCID: PMC16664.
    View in: PubMed, PubMed Central
  153. Lori F, Jessen H, Lieberman J, Finzi D, Rosenberg E, Tinelli C, Walker B, Siliciano RF, Lisziewicz J. Treatment of human immunodeficiency virus infection with hydroxyurea, didanosine, and a protease inhibitor before seroconversion is associated with normalized immune parameters and limited viral reservoir. J Infect Dis. 1999 Dec; 180(6):1827-32. PMID: 10558937.
    View in: PubMed
  154. Manjunath N, Shankar P, Stockton B, Dubey PD, Lieberman J, von Andrian UH. A transgenic mouse model to analyze CD8(+) effector T cell differentiation in vivo. Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24):13932-7. PMID: 10570176; PMCID: PMC24168.
    View in: PubMed, PubMed Central
  155. Shankar P, Xu Z, Lieberman J. Viral-specific cytotoxic T lymphocytes lyse human immunodeficiency virus-infected primary T lymphocytes by the granule exocytosis pathway. Blood. 1999 Nov 01; 94(9):3084-93. PMID: 10556193.
    View in: PubMed
  156. Lori F, Rosenberg E, Lieberman J, Foli A, Maserati R, Seminari E, Alberici F, Walker B, Lisziewicz J. Hydroxyurea and didanosine long-term treatment prevents HIV breakthrough and normalizes immune parameters. AIDS Res Hum Retroviruses. 1999 Oct 10; 15(15):1333-8. PMID: 10515148.
    View in: PubMed
  157. Andersson J, Behbahani H, Lieberman J, Connick E, Landay A, Patterson B, Sönnerborg A, Loré K, Uccini S, Fehniger TE. Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection. AIDS. 1999 Jul 30; 13(11):1295-303. PMID: 10449281.
    View in: PubMed
  158. Lieberman J, Trimble LA, Friedman RS, Lisziewicz J, Lori F, Shankar P, Jessen H. Expansion of CD57 and CD62L-CD45RA+ CD8 T lymphocytes correlates with reduced viral plasma RNA after primary HIV infection. AIDS. 1999 May 28; 13(8):891-9. PMID: 10371169.
    View in: PubMed
  159. Lisziewicz J, Rosenberg E, Lieberman J, Jessen H, Lopalco L, Siliciano R, Walker B, Lori F. Control of HIV despite the discontinuation of antiretroviral therapy. N Engl J Med. 1999 May 27; 340(21):1683-4. PMID: 10348681.
    View in: PubMed
  160. Trimble LA, Xu Z, Lieberman J. Clonal expansion of antigen-specific CD8+ cytotoxic T lymphocytes is regulated by late exposure to serum to prevent apoptosis. J Immunol Methods. 1999 May 27; 225(1-2):39-52. PMID: 10365780.
    View in: PubMed
  161. Lori F, Jessen H, Lieberman J, Clerici M, Tinelli C, Lisziewicz J. Immune restoration by combination of a cytostatic drug (hydroxyurea) and anti-HIV drugs (didanosine and indinavir). AIDS Res Hum Retroviruses. 1999 May 01; 15(7):619-24. PMID: 10331440.
    View in: PubMed
  162. Beresford PJ, Xia Z, Greenberg AH, Lieberman J. Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation. Immunity. 1999 May; 10(5):585-94. PMID: 10367904.
    View in: PubMed
  163. MacDonald G, Shi L, Vande Velde C, Lieberman J, Greenberg AH. Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis. J Exp Med. 1999 Jan 04; 189(1):131-44. PMID: 9874570; PMCID: PMC1887691.
    View in: PubMed, PubMed Central
  164. Shankar P, Sprang H, Lieberman J. Effective lysis of HIV-1-infected primary CD4+ T cells by a cytotoxic T-lymphocyte clone directed against a novel A2-restricted reverse-transcriptase epitope. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Oct 01; 19(2):111-20. PMID: 9768618.
    View in: PubMed
  165. Beresford PJ, Jaju M, Friedman RS, Yoon MJ, Lieberman J. A role for heat shock protein 27 in CTL-mediated cell death. J Immunol. 1998 Jul 01; 161(1):161-7. PMID: 9647220.
    View in: PubMed
  166. Xia Z, Kam CM, Huang C, Powers JC, Mandle RJ, Stevens RL, Lieberman J. Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system. Biochem Biophys Res Commun. 1998 Feb 13; 243(2):384-9. PMID: 9480818.
    View in: PubMed
  167. Trimble LA, Lieberman J. Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3 zeta, the signaling chain of the T-cell receptor complex. Blood. 1998 Jan 15; 91(2):585-94. PMID: 9427713.
    View in: PubMed
  168. Lieberman J, Skolnik PR, Parkerson GR, Fabry JA, Landry B, Bethel J, Kagan J. Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients. Blood. 1997 Sep 15; 90(6):2196-206. PMID: 9310470.
    View in: PubMed
  169. Beresford PJ, Kam CM, Powers JC, Lieberman J. Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9285-90. PMID: 9256474; PMCID: PMC23158.
    View in: PubMed, PubMed Central
  170. Turbay D, Lieberman J, Alper CA, Delgado JC, Corzo D, Yunis JJ, Yunis EJ. Tumor necrosis factor constellation polymorphism and clozapine-induced agranulocytosis in two different ethnic groups. Blood. 1997 Jun 01; 89(11):4167-74. PMID: 9166860.
    View in: PubMed
  171. Lieberman J, Fabry JA, Fong DM, Parkerson GR. Recognition of a small number of diverse epitopes dominates the cytotoxic T lymphocytes response to HIV type 1 in an infected individual. AIDS Res Hum Retroviruses. 1997 Mar 20; 13(5):383-92. PMID: 9075479.
    View in: PubMed
  172. Buchsbaum RJ, Fabry JA, Lieberman J. EBV-specific cytotoxic T lymphocytes protect against human EBV-associated lymphoma in scid mice. Immunol Lett. 1996 Sep; 52(2-3):145-52. PMID: 8905410.
    View in: PubMed
  173. Shankar P, Fabry JA, Fong DM, Lieberman J. Three regions of HIV-1 gp160 contain clusters of immunodominant CTL epitopes. Immunol Lett. 1996 Aug; 52(1):23-30. PMID: 8877415.
    View in: PubMed
  174. Decker LL, Shankar P, Khan G, Freeman RB, Dezube BJ, Lieberman J, Thorley-Lawson DA. The Kaposi sarcoma-associated herpesvirus (KSHV) is present as an intact latent genome in KS tissue but replicates in the peripheral blood mononuclear cells of KS patients. J Exp Med. 1996 Jul 01; 184(1):283-8. PMID: 8691144; PMCID: PMC2192669.
    View in: PubMed, PubMed Central
  175. Perales MA, Skolnik PR, Lieberman J. Effect of interleukin 12 on in vitro HIV type 1 replication depends on clinical stage. AIDS Res Hum Retroviruses. 1996 May 20; 12(8):659-68. PMID: 8744576.
    View in: PubMed
  176. Roberts CG, Meister GE, Jesdale BM, Lieberman J, Berzofsky JA, De Groot AS. Prediction of HIV peptide epitopes by a novel algorithm. AIDS Res Hum Retroviruses. 1996 May 01; 12(7):593-610. PMID: 8743085.
    View in: PubMed
  177. Frankel FR, Hegde S, Lieberman J, Paterson Y. Induction of cell-mediated immune responses to human immunodeficiency virus type 1 Gag protein by using Listeria monocytogenes as a live vaccine vector. J Immunol. 1995 Nov 15; 155(10):4775-82. PMID: 7594479.
    View in: PubMed
  178. Srinivas RV, Su T, Trimble LA, Lieberman J, Ardman B. Enhanced susceptibility to human immunodeficiency virus infection in CD4+ T lymphocytes genetically deficient in CD43. AIDS Res Hum Retroviruses. 1995 Sep; 11(9):1015-21. PMID: 8554898.
    View in: PubMed
  179. Perales MA, Schwartz DH, Fabry JA, Lieberman J. A vaccinia-gp160-based vaccine but not a gp160 protein vaccine elicits anti-gp160 cytotoxic T lymphocytes in some HIV-1 seronegative vaccinees. J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Sep 01; 10(1):27-35. PMID: 7648281.
    View in: PubMed
  180. Shankar P, Fabry J, Lieberman J. A simple method to selectively expand HIV-1 specific cytotoxic T lymphocytes in vitro. Immunol Invest. 1995 Mar; 24(3):489-97. PMID: 7790045.
    View in: PubMed
  181. Lieberman J, Fabry JA, Shankar P, Beckett L, Skolnik PR. Ex vivo expansion of HIV type 1-specific cytolytic T cells from HIV type 1-seropositive subjects. AIDS Res Hum Retroviruses. 1995 Feb; 11(2):257-71. PMID: 7742040.
    View in: PubMed
  182. McFarland TA, Ardman B, Manjunath N, Fabry JA, Lieberman J. CD43 diminishes susceptibility to T lymphocyte-mediated cytolysis. J Immunol. 1995 Feb 01; 154(3):1097-104. PMID: 7822786.
    View in: PubMed
  183. Schwartz D, Sharma U, Busch M, Weinhold K, Matthews T, Lieberman J, Birx D, Farzedagen H, Margolick J, Quinn T, et al. Absence of recoverable infectious virus and unique immune responses in an asymptomatic HIV+ long-term survivor. AIDS Res Hum Retroviruses. 1994 Dec; 10(12):1703-11. PMID: 7888230.
    View in: PubMed
  184. Lieberman J, Buchsbaum RJ. Using T cells to treat B-cell cancers. N Engl J Med. 1994 Apr 28; 330(17):1231-3. PMID: 8139635.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Lieberman's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
See all (752) concept(s)
_
Co-Authors Expand Description
See all (82) people
_
Similar People Expand Description
See all (60) people
_
Same Department Expand Description
Search Department
Physical Neighbors Expand Description
_