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Judy Lieberman, M.D., PH.D.

Title
Institution
Department
Address
Phone
Fax

Mentoring
completed student projects
Synthesis of a bifunctional chimera: Discriminate delivery of siRNA to CD4+ cells by fusion to RNA-based aptamers
Summer, 01/02/07 - 08/15/07
Understanding the role of tumor-derived extracellular vesicles in breast cancer metastasis
Summer, 06/05/15 - 08/28/15

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. R21AI131632 (GAZZINELLI, RICARDO) Jan 9, 2018 - Dec 31, 2019
    NIH/NIAID
    Killing of P. vivax infected reticulocytes by cytotoxic T cells
    Role: Co-Principal Investigator
  2. R21HD087689 (STROMINGER, JACK L) Mar 4, 2016 - Feb 28, 2018
    NIH/NICHD
    Control of placental infection by decidual NK cell secreted granulysin
    Role: Principal Investigator
  3. R01AI116577 (LIEBERMAN, JUDY) Mar 1, 2016 - Feb 28, 2021
    NIH/NIAID
    Granzyme and Granulysin Mediated Death of Trypanosoma cruzi
    Role: Co-Principal Investigator
  4. R01AI123265 (LIEBERMAN, JUDY) Feb 15, 2016 - Jan 31, 2021
    NIH/NIAID
    Granulysin, Granzymes and Perforin in Bacterial Immune Defense
    Role: Principal Investigator
  5. R01CA184718 (LIEBERMAN, JUDY) Sep 24, 2015 - Aug 31, 2020
    NIH/NCI
    Aptamer-siRNA gene knockdown to treat epithelial triple negative breast cancer
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Liu X, Fu R, Pan Y, Meza-Sosa KF, Zhang Z, Lieberman J. PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs. Cell. 2018 May 10. PMID: 29779946.
    View in: PubMed
  2. Ruan J, Xia S, Liu X, Lieberman J, Wu H. Cryo-EM structure of the gasdermin A3 membrane pore. Nature. 2018 May; 557(7703):62-67. PMID: 29695864.
    View in: PubMed
  3. Clayton KL, Collins DR, Lengieza J, Ghebremichael M, Dotiwala F, Lieberman J, Walker BD. Resistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system. Nat Immunol. 2018 May; 19(5):475-486. PMID: 29670239.
    View in: PubMed
  4. Lieberman J. Tapping the RNA world for therapeutics. Nat Struct Mol Biol. 2018 May; 25(5):357-364. PMID: 29662218.
    View in: PubMed
  5. Doan M, Vorobjev I, Rees P, Filby A, Wolkenhauer O, Goldfeld AE, Lieberman J, Barteneva N, Carpenter AE, Hennig H. Diagnostic Potential of Imaging Flow Cytometry. Trends Biotechnol. 2018 Jul; 36(7):649-652. PMID: 29395345.
    View in: PubMed
  6. Kedmi R, Veiga N, Ramishetti S, Goldsmith M, Rosenblum D, Dammes N, Hazan-Halevy I, Nahary L, Leviatan-Ben-Arye S, Harlev M, Behlke M, Benhar I, Lieberman J, Peer D. A modular platform for targeted RNAi therapeutics. Nat Nanotechnol. 2018 Mar; 13(3):214-219. PMID: 29379205.
    View in: PubMed
  7. Sula Karreci E, Eskandari SK, Dotiwala F, Routray SK, Kurdi AT, Assaker JP, Luckyanchykov P, Mihali AB, Maarouf O, Borges TJ, Alkhudhayri A, Patel KR, Radwan A, Ghobrial I, McGrath M, Chandraker A, Riella LV, Elyaman W, Abdi R, Lieberman J, Azzi J. Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation. JCI Insight. 2017 Nov 02; 2(21). PMID: 29093262.
    View in: PubMed
  8. Dotiwala F, Sen Santara S, Binker-Cosen AA, Li B, Chandrasekaran S, Lieberman J. Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program. Cell. 2017 Nov 16; 171(5):1125-1137.e11. PMID: 29107333.
    View in: PubMed
  9. Chan S, Sridhar P, Kirchner R, Lock YJ, Herbert Z, Buonamici S, Smith P, Lieberman J, Petrocca F. Basal-A Triple-Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival. Mol Cancer Ther. 2017 Dec; 16(12):2849-2861. PMID: 28878028.
    View in: PubMed
  10. Deruaz M, Murooka TT, Ji S, Gavin MA, Vrbanac VD, Lieberman J, Tager AM, Mempel TR, Luster AD. Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa. JCI Insight. 2017 Apr 06; 2(7):e88533. PMID: 28405607.
    View in: PubMed
  11. Liu X, Lieberman J. A Mechanistic Understanding of Pyroptosis: The Fiery Death Triggered by Invasive Infection. Adv Immunol. 2017; 135:81-117. PMID: 28826530.
    View in: PubMed
  12. Su S, Liao J, Liu J, Huang D, He C, Chen F, Yang L, Wu W, Chen J, Lin L, Zeng Y, Ouyang N, Cui X, Yao H, Su F, Huang JD, Lieberman J, Liu Q, Song E. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res. 2017 Apr; 27(4):461-482. PMID: 28290464.
    View in: PubMed
  13. Liu X, Lieberman J. How ICE lights the pyroptosis fire. Cell Death Differ. 2017 02; 24(2):197-199. PMID: 28060375.
    View in: PubMed
  14. Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 2016 07 07; 535(7610):153-8. PMID: 27383986.
    View in: PubMed
  15. Wheeler LA, Trifonova RT, Vrbanac V, Barteneva NS, Liu X, Bollman B, Onofrey L, Mulik S, Ranjbar S, Luster AD, Tager AM, Lieberman J. TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice. Cell Rep. 2016 05 24; 15(8):1715-27. PMID: 27184854; PMCID: PMC4881429.
    View in: PubMed, PubMed Central
  16. Boulias K, Lieberman J, Greer EL. An Epigenetic Clock Measures Accelerated Aging in Treated HIV Infection. Mol Cell. 2016 04 21; 62(2):153-155. PMID: 27105110.
    View in: PubMed
  17. Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, Thomas M, Lieberman J, McInerney GM, Ivanov P, Anderson P. G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol. 2016 Mar 28; 212(7):845-60. PMID: 27022092; PMCID: PMC4810302.
    View in: PubMed, PubMed Central
  18. Basu R, Whitlock BM, Husson J, Le Floc'h A, Jin W, Oyler-Yaniv A, Dotiwala F, Giannone G, Hivroz C, Biais N, Lieberman J, Kam LC, Huse M. Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing. Cell. 2016 Mar 24; 165(1):100-110. PMID: 26924577; PMCID: PMC4808403 [Available on 03/24/17].
    View in: PubMed, PubMed Central
  19. Dotiwala F, Mulik S, Polidoro RB, Ansara JA, Burleigh BA, Walch M, Gazzinelli RT, Lieberman J. Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites. Nat Med. 2016 Feb; 22(2):210-6. PMID: 26752517.
    View in: PubMed
  20. Tan SM, Lieberman J. Capture and Identification of miRNA Targets by Biotin Pulldown and RNA-seq. Methods Mol Biol. 2016; 1358:211-28. PMID: 26463386.
    View in: PubMed
  21. Weinstein S, Toker IA, Emmanuel R, Ramishetti S, Hazan-Halevy I, Rosenblum D, Goldsmith M, Abraham A, Benjamini O, Bairey O, Raanani P, Nagler A, Lieberman J, Peer D. Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies. Proc Natl Acad Sci U S A. 2016 Jan 05; 113(1):E16-22. PMID: 26699502; PMCID: PMC4711827.
    View in: PubMed, PubMed Central
  22. Wittrup A, Lieberman J. Knocking down disease: a progress report on siRNA therapeutics. Nat Rev Genet. 2015 Sep; 16(9):543-52. PMID: 26281785; PMCID: PMC4756474.
    View in: PubMed, PubMed Central
  23. Gilboa-Geffen A, Hamar P, Le MT, Wheeler LA, Trifonova R, Petrocca F, Wittrup A, Lieberman J. Gene Knockdown by EpCAM Aptamer-siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells. Mol Cancer Ther. 2015 Oct; 14(10):2279-91. PMID: 26264278.
    View in: PubMed
  24. Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J. Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown. Nat Biotechnol. 2015 Aug; 33(8):870-6. PMID: 26192320; PMCID: PMC4663660.
    View in: PubMed, PubMed Central
  25. Navarro F, Lieberman J. miR-34 and p53: New Insights into a Complex Functional Relationship. PLoS One. 2015; 10(7):e0132767. PMID: 26177460; PMCID: PMC4503669.
    View in: PubMed, PubMed Central
  26. Lieberman J. Manipulating the in vivo immune response by targeted gene knockdown. Curr Opin Immunol. 2015 Aug; 35:63-72. PMID: 26149459; PMCID: PMC4498257.
    View in: PubMed, PubMed Central
  27. Dotiwala F, Fellay I, Filgueira L, Martinvalet D, Lieberman J, Walch M. A High Yield and Cost-efficient Expression System of Human Granzymes in Mammalian Cells. J Vis Exp. 2015 Jun 10; (100):e52911. PMID: 26132420.
    View in: PubMed
  28. O'Day E, Le MT, Imai S, Tan SM, Kirchner R, Arthanari H, Hofmann O, Wagner G, Lieberman J. An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates. J Biol Chem. 2015 Jul 17; 290(29):17909-22. PMID: 26045559; PMCID: PMC4505039.
    View in: PubMed, PubMed Central
  29. Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J. Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes. Cell. 2015 May 21; 161(5):1229. PMID: 28910642.
    View in: PubMed
  30. Thomas MP, Liu X, Whangbo J, McCrossan G, Sanborn KB, Basar E, Walch M, Lieberman J. Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2. Cell Rep. 2015 May 19; 11(7):1079-89. PMID: 25959823; PMCID: PMC4862650.
    View in: PubMed, PubMed Central
  31. Sharei A, Trifonova R, Jhunjhunwala S, Hartoularos GC, Eyerman AT, Lytton-Jean A, Angin M, Sharma S, Poceviciute R, Mao S, Heimann M, Liu S, Talkar T, Khan OF, Addo M, von Andrian UH, Anderson DG, Langer R, Lieberman J, Jensen KF. Ex vivo cytosolic delivery of functional macromolecules to immune cells. PLoS One. 2015; 10(4):e0118803. PMID: 25875117; PMCID: PMC4395260.
    View in: PubMed, PubMed Central
  32. Luo ML, Gong C, Chen CH, Hu H, Huang P, Zheng M, Yao Y, Wei S, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation. Cell Rep. 2015 Apr 07; 11(1):111-24. PMID: 25818297; PMCID: PMC4401741.
    View in: PubMed, PubMed Central
  33. Hata A, Lieberman J. Dysregulation of microRNA biogenesis and gene silencing in cancer. Sci Signal. 2015 Mar 17; 8(368):re3. PMID: 25783160.
    View in: PubMed
  34. Lieberman J, Sharp PA. Harnessing RNA interference for therapy: the silent treatment. JAMA. 2015 Mar 24-31; 313(12):1207-8. PMID: 25803342.
    View in: PubMed
  35. Le MT, Hamar P, Guo C, Basar E, Perdigão-Henriques R, Balaj L, Lieberman J. miR-200-containing extracellular vesicles promote breast cancer cell metastasis. J Clin Invest. 2014 Dec; 124(12):5109-28. PMID: 25401471; PMCID: PMC4348969.
    View in: PubMed, PubMed Central
  36. Ivanov P, O'Day E, Emara MM, Wagner G, Lieberman J, Anderson P. G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18201-6. PMID: 25404306; PMCID: PMC4280610.
    View in: PubMed, PubMed Central
  37. Wheeler LA, Lieberman J. Developing an Effective Rectal Microbicide: Inhibiting HIV Transmission in Human Colorectal Tissue and Humanized Mice with CD4 Aptamer-siRNA Chimeras. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A206. PMID: 25357578.
    View in: PubMed
  38. Wheeler LA, Lieberman J. Inhibiting the Host Exonuclease TREX1 Induces a Localized and Protective Host Interferon Response against Acute HIV Infection In Vivo. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A41. PMID: 25357849.
    View in: PubMed
  39. Tan SM, Kirchner R, Jin J, Hofmann O, McReynolds L, Hide W, Lieberman J. Sequencing of captive target transcripts identifies the network of regulated genes and functions of primate-specific miR-522. Cell Rep. 2014 Aug 21; 8(4):1225-39. PMID: 25131211.
    View in: PubMed
  40. Tay Y, Tan SM, Karreth FA, Lieberman J, Pandolfi PP. Characterization of dual PTEN and p53-targeting microRNAs identifies microRNA-638/Dnm2 as a two-hit oncogenic locus. Cell Rep. 2014 Aug 07; 8(3):714-22. PMID: 25088422; PMCID: PMC4128194.
    View in: PubMed, PubMed Central
  41. Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J. Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes. Cell. 2014 Jun 05; 157(6):1309-23. PMID: 24906149; PMCID: PMC4090916.
    View in: PubMed, PubMed Central
  42. Luo ML, Gong C, Chen CH, Lee DY, Hu H, Huang P, Yao Y, Guo W, Reinhardt F, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer. Cancer Res. 2014 Jul 01; 74(13):3603-16. PMID: 24786790; PMCID: PMC4079726.
    View in: PubMed, PubMed Central
  43. Thomas MP, Whangbo J, McCrossan G, Deutsch AJ, Martinod K, Walch M, Lieberman J. Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins. J Immunol. 2014 Jun 01; 192(11):5390-7. PMID: 24771851; PMCID: PMC4041364.
    View in: PubMed, PubMed Central
  44. Trifonova RT, Lieberman J, van Baarle D. Distribution of immune cells in the human cervix and implications for HIV transmission. Am J Reprod Immunol. 2014 Mar; 71(3):252-64. PMID: 24410939; PMCID: PMC3943534.
    View in: PubMed, PubMed Central
  45. Thiery J, Lieberman J. Perforin: a key pore-forming protein for immune control of viruses and cancer. Subcell Biochem. 2014; 80:197-220. PMID: 24798013.
    View in: PubMed
  46. Huang L, Lieberman J. Production of highly potent recombinant siRNAs in Escherichia coli. Nat Protoc. 2013 Dec; 8(12):2325-36. PMID: 24177290.
    View in: PubMed
  47. Tuli A, Thiery J, James AM, Michelet X, Sharma M, Garg S, Sanborn KB, Orange JS, Lieberman J, Brenner MB. Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. Mol Biol Cell. 2013 Dec; 24(23):3721-35. PMID: 24088571; PMCID: PMC3842998.
    View in: PubMed, PubMed Central
  48. Petrocca F, Altschuler G, Tan SM, Mendillo ML, Yan H, Jerry DJ, Kung AL, Hide W, Ince TA, Lieberman J. A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells. Cancer Cell. 2013 Aug 12; 24(2):182-96. PMID: 23948298; PMCID: PMC3773329.
    View in: PubMed, PubMed Central
  49. Thomas MP, Lieberman J. Live or let die: posttranscriptional gene regulation in cell stress and cell death. Immunol Rev. 2013 May; 253(1):237-52. PMID: 23550650.
    View in: PubMed
  50. Wheeler LA, Vrbanac V, Trifonova R, Brehm MA, Gilboa-Geffen A, Tanno S, Greiner DL, Luster AD, Tager AM, Lieberman J. Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras. Mol Ther. 2013 Jul; 21(7):1378-89. PMID: 23629001; PMCID: PMC3702101.
    View in: PubMed, PubMed Central
  51. Lieberman J, Slack F, Pandolfi PP, Chinnaiyan A, Agami R, Mendell JT. Noncoding RNAs and cancer. Cell. 2013 Mar 28; 153(1):9-10. PMID: 23781554.
    View in: PubMed
  52. Huang L, Jin J, Deighan P, Kiner E, McReynolds L, Lieberman J. Efficient and specific gene knockdown by small interfering RNAs produced in bacteria. Nat Biotechnol. 2013 Apr; 31(4):350-6. PMID: 23475073; PMCID: PMC3622153.
    View in: PubMed, PubMed Central
  53. Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N. Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nat Immunol. 2013 Feb; 14(2):179-85. PMID: 23263557; PMCID: PMC3838897.
    View in: PubMed, PubMed Central
  54. Yan N, Lieberman J. SAMHD1 does it again, now in resting T cells. Nat Med. 2012 Nov; 18(11):1611-2. PMID: 23135508; PMCID: PMC4036678.
    View in: PubMed, PubMed Central
  55. Rajani DK, Walch M, Martinvalet D, Thomas MP, Lieberman J. Alterations in RNA processing during immune-mediated programmed cell death. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8688-93. PMID: 22589304; PMCID: PMC3365155.
    View in: PubMed, PubMed Central
  56. Yao YD, Sun TM, Huang SY, Dou S, Lin L, Chen JN, Ruan JB, Mao CQ, Yu FY, Zeng MS, Zang JY, Liu Q, Su FX, Zhang P, Lieberman J, Wang J, Song E. Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis. Sci Transl Med. 2012 Apr 18; 4(130):130ra48. PMID: 22517885.
    View in: PubMed
  57. Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A. Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem. 2012 Feb 03; 287(6):3976-86. PMID: 22158624; PMCID: PMC3281737.
    View in: PubMed, PubMed Central
  58. Lal A, Thomas MP, Altschuler G, Navarro F, O'Day E, Li XL, Concepcion C, Han YC, Thiery J, Rajani DK, Deutsch A, Hofmann O, Ventura A, Hide W, Lieberman J. Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet. 2011 Nov; 7(11):e1002363. PMID: 22102825; PMCID: PMC3213160.
    View in: PubMed, PubMed Central
  59. Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L, Provero P, Di Cunto F, Lieberman J, Rigoutsos I, Pandolfi PP. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell. 2011 Oct 14; 147(2):344-57. PMID: 22000013; PMCID: PMC3235920.
    View in: PubMed, PubMed Central
  60. Le MT, Shyh-Chang N, Khaw SL, Chin L, Teh C, Tay J, O'Day E, Korzh V, Yang H, Lal A, Lieberman J, Lodish HF, Lim B. Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet. 2011 Sep; 7(9):e1002242. PMID: 21935352; PMCID: PMC3174204.
    View in: PubMed, PubMed Central
  61. Lakhashe SK, Velu V, Sciaranghella G, Siddappa NB, Dipasquale JM, Hemashettar G, Yoon JK, Rasmussen RA, Yang F, Lee SJ, Montefiori DC, Novembre FJ, Villinger F, Amara RR, Kahn M, Hu SL, Li S, Li Z, Frankel FR, Robert-Guroff M, Johnson WE, Lieberman J, Ruprecht RM. Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges. Vaccine. 2011 Aug 05; 29(34):5611-22. PMID: 21693155; PMCID: PMC3154722.
    View in: PubMed, PubMed Central
  62. Thiery J, Keefe D, Boulant S, Boucrot E, Walch M, Martinvalet D, Goping IS, Bleackley RC, Kirchhausen T, Lieberman J. Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat Immunol. 2011 Jun 19; 12(8):770-7. PMID: 21685908; PMCID: PMC3140544.
    View in: PubMed, PubMed Central
  63. Wheeler LA, Trifonova R, Vrbanac V, Basar E, McKernan S, Xu Z, Seung E, Deruaz M, Dudek T, Einarsson JI, Yang L, Allen TM, Luster AD, Tager AM, Dykxhoorn DM, Lieberman J. Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. J Clin Invest. 2011 Jun; 121(6):2401-12. PMID: 21576818; PMCID: PMC3104760.
    View in: PubMed, PubMed Central
  64. Yan N, O'Day E, Wheeler LA, Engelman A, Lieberman J. HIV DNA is heavily uracilated, which protects it from autointegration. Proc Natl Acad Sci U S A. 2011 May 31; 108(22):9244-9. PMID: 21576478; PMCID: PMC3107311.
    View in: PubMed, PubMed Central
  65. Whitney JB, Mirshahidi S, Lim SY, Goins L, Ibegbu CC, Anderson DC, Raybourne RB, Frankel FR, Lieberman J, Ruprecht RM. Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV. J Immune Based Ther Vaccines. 2011 Jan 18; 9:2. PMID: 21244649; PMCID: PMC3033796.
    View in: PubMed, PubMed Central
  66. Yan N, Lieberman J. Gaining a foothold: how HIV avoids innate immune recognition. Curr Opin Immunol. 2011 Feb; 23(1):21-8. PMID: 21123040; PMCID: PMC3042516.
    View in: PubMed, PubMed Central
  67. Petrocca F, Lieberman J. Promise and challenge of RNA interference-based therapy for cancer. J Clin Oncol. 2011 Feb 20; 29(6):747-54. PMID: 21079135.
    View in: PubMed
  68. Thomas M, Lieberman J, Lal A. Desperately seeking microRNA targets. Nat Struct Mol Biol. 2010 Oct; 17(10):1169-74. PMID: 20924405.
    View in: PubMed
  69. Yan N, Regalado-Magdos AD, Stiggelbout B, Lee-Kirsch MA, Lieberman J. The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol. 2010 Nov; 11(11):1005-13. PMID: 20871604; PMCID: PMC2958248.
    View in: PubMed, PubMed Central
  70. Navarro F, Lieberman J. Small RNAs guide hematopoietic cell differentiation and function. J Immunol. 2010 Jun 01; 184(11):5939-47. PMID: 20483778.
    View in: PubMed
  71. Thiery J, Walch M, Jensen DK, Martinvalet D, Lieberman J. Isolation of cytotoxic T cell and NK granules and purification of their effector proteins. Curr Protoc Cell Biol. 2010 Jun; Chapter 3:Unit3.37. PMID: 20521234.
    View in: PubMed
  72. Lieberman J. Anatomy of a murder: how cytotoxic T cells and NK cells are activated, develop, and eliminate their targets. Immunol Rev. 2010 May; 235(1):5-9. PMID: 20536551.
    View in: PubMed
  73. Lieberman J. Granzyme A activates another way to die. Immunol Rev. 2010 May; 235(1):93-104. PMID: 20536557; PMCID: PMC2905780.
    View in: PubMed, PubMed Central
  74. Niland B, Miklossy G, Banki K, Biddison WE, Casciola-Rosen L, Rosen A, Martinvalet D, Lieberman J, Perl A. Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients. J Immunol. 2010 Apr 01; 184(7):4025-32. PMID: 20194725; PMCID: PMC3117466.
    View in: PubMed, PubMed Central
  75. Thiery J, Keefe D, Saffarian S, Martinvalet D, Walch M, Boucrot E, Kirchhausen T, Lieberman J. Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis. Blood. 2010 Feb 25; 115(8):1582-93. PMID: 20038786; PMCID: PMC2830763.
    View in: PubMed, PubMed Central
  76. Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A. Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J. 2010 Feb 03; 29(3):559-73. PMID: 20019669; PMCID: PMC2830697.
    View in: PubMed, PubMed Central
  77. Lieberman J. Micromanaging cancer. N Engl J Med. 2009 Oct 08; 361(15):1500-1. PMID: 19812408.
    View in: PubMed
  78. Dykxhoorn DM, Wu Y, Xie H, Yu F, Lal A, Petrocca F, Martinvalet D, Song E, Lim B, Lieberman J. miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS One. 2009 Sep 29; 4(9):e7181. PMID: 19787069; PMCID: PMC2749331.
    View in: PubMed, PubMed Central
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  167. Lori F, Rosenberg E, Lieberman J, Foli A, Maserati R, Seminari E, Alberici F, Walker B, Lisziewicz J. Hydroxyurea and didanosine long-term treatment prevents HIV breakthrough and normalizes immune parameters. AIDS Res Hum Retroviruses. 1999 Oct 10; 15(15):1333-8. PMID: 10515148.
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  168. Andersson J, Behbahani H, Lieberman J, Connick E, Landay A, Patterson B, Sönnerborg A, Loré K, Uccini S, Fehniger TE. Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection. AIDS. 1999 Jul 30; 13(11):1295-303. PMID: 10449281.
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  169. Lieberman J, Trimble LA, Friedman RS, Lisziewicz J, Lori F, Shankar P, Jessen H. Expansion of CD57 and CD62L-CD45RA+ CD8 T lymphocytes correlates with reduced viral plasma RNA after primary HIV infection. AIDS. 1999 May 28; 13(8):891-9. PMID: 10371169.
    View in: PubMed
  170. Lisziewicz J, Rosenberg E, Lieberman J, Jessen H, Lopalco L, Siliciano R, Walker B, Lori F. Control of HIV despite the discontinuation of antiretroviral therapy. N Engl J Med. 1999 May 27; 340(21):1683-4. PMID: 10348681.
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  171. Trimble LA, Xu Z, Lieberman J. Clonal expansion of antigen-specific CD8+ cytotoxic T lymphocytes is regulated by late exposure to serum to prevent apoptosis. J Immunol Methods. 1999 May 27; 225(1-2):39-52. PMID: 10365780.
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  172. Lori F, Jessen H, Lieberman J, Clerici M, Tinelli C, Lisziewicz J. Immune restoration by combination of a cytostatic drug (hydroxyurea) and anti-HIV drugs (didanosine and indinavir). AIDS Res Hum Retroviruses. 1999 May 01; 15(7):619-24. PMID: 10331440.
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  173. Beresford PJ, Xia Z, Greenberg AH, Lieberman J. Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation. Immunity. 1999 May; 10(5):585-94. PMID: 10367904.
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  174. MacDonald G, Shi L, Vande Velde C, Lieberman J, Greenberg AH. Mitochondria-dependent and -independent regulation of Granzyme B-induced apoptosis. J Exp Med. 1999 Jan 04; 189(1):131-44. PMID: 9874570; PMCID: PMC1887691.
    View in: PubMed, PubMed Central
  175. Shankar P, Sprang H, Lieberman J. Effective lysis of HIV-1-infected primary CD4+ T cells by a cytotoxic T-lymphocyte clone directed against a novel A2-restricted reverse-transcriptase epitope. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Oct 01; 19(2):111-20. PMID: 9768618.
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  176. Beresford PJ, Jaju M, Friedman RS, Yoon MJ, Lieberman J. A role for heat shock protein 27 in CTL-mediated cell death. J Immunol. 1998 Jul 01; 161(1):161-7. PMID: 9647220.
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  177. Xia Z, Kam CM, Huang C, Powers JC, Mandle RJ, Stevens RL, Lieberman J. Expression and purification of enzymatically active recombinant granzyme B in a baculovirus system. Biochem Biophys Res Commun. 1998 Feb 13; 243(2):384-9. PMID: 9480818.
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  178. Trimble LA, Lieberman J. Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3 zeta, the signaling chain of the T-cell receptor complex. Blood. 1998 Jan 15; 91(2):585-94. PMID: 9427713.
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  179. Lieberman J, Skolnik PR, Parkerson GR, Fabry JA, Landry B, Bethel J, Kagan J. Safety of autologous, ex vivo-expanded human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte infusion in HIV-infected patients. Blood. 1997 Sep 15; 90(6):2196-206. PMID: 9310470.
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  180. Beresford PJ, Kam CM, Powers JC, Lieberman J. Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9285-90. PMID: 9256474; PMCID: PMC23158.
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  181. Turbay D, Lieberman J, Alper CA, Delgado JC, Corzo D, Yunis JJ, Yunis EJ. Tumor necrosis factor constellation polymorphism and clozapine-induced agranulocytosis in two different ethnic groups. Blood. 1997 Jun 01; 89(11):4167-74. PMID: 9166860.
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  182. Lieberman J, Fabry JA, Fong DM, Parkerson GR. Recognition of a small number of diverse epitopes dominates the cytotoxic T lymphocytes response to HIV type 1 in an infected individual. AIDS Res Hum Retroviruses. 1997 Mar 20; 13(5):383-92. PMID: 9075479.
    View in: PubMed
  183. Buchsbaum RJ, Fabry JA, Lieberman J. EBV-specific cytotoxic T lymphocytes protect against human EBV-associated lymphoma in scid mice. Immunol Lett. 1996 Sep; 52(2-3):145-52. PMID: 8905410.
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  184. Shankar P, Fabry JA, Fong DM, Lieberman J. Three regions of HIV-1 gp160 contain clusters of immunodominant CTL epitopes. Immunol Lett. 1996 Aug; 52(1):23-30. PMID: 8877415.
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  185. Decker LL, Shankar P, Khan G, Freeman RB, Dezube BJ, Lieberman J, Thorley-Lawson DA. The Kaposi sarcoma-associated herpesvirus (KSHV) is present as an intact latent genome in KS tissue but replicates in the peripheral blood mononuclear cells of KS patients. J Exp Med. 1996 Jul 01; 184(1):283-8. PMID: 8691144; PMCID: PMC2192669.
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  186. Perales MA, Skolnik PR, Lieberman J. Effect of interleukin 12 on in vitro HIV type 1 replication depends on clinical stage. AIDS Res Hum Retroviruses. 1996 May 20; 12(8):659-68. PMID: 8744576.
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  187. Roberts CG, Meister GE, Jesdale BM, Lieberman J, Berzofsky JA, De Groot AS. Prediction of HIV peptide epitopes by a novel algorithm. AIDS Res Hum Retroviruses. 1996 May 01; 12(7):593-610. PMID: 8743085.
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  188. Frankel FR, Hegde S, Lieberman J, Paterson Y. Induction of cell-mediated immune responses to human immunodeficiency virus type 1 Gag protein by using Listeria monocytogenes as a live vaccine vector. J Immunol. 1995 Nov 15; 155(10):4775-82. PMID: 7594479.
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  189. Srinivas RV, Su T, Trimble LA, Lieberman J, Ardman B. Enhanced susceptibility to human immunodeficiency virus infection in CD4+ T lymphocytes genetically deficient in CD43. AIDS Res Hum Retroviruses. 1995 Sep; 11(9):1015-21. PMID: 8554898.
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  190. Perales MA, Schwartz DH, Fabry JA, Lieberman J. A vaccinia-gp160-based vaccine but not a gp160 protein vaccine elicits anti-gp160 cytotoxic T lymphocytes in some HIV-1 seronegative vaccinees. J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Sep 01; 10(1):27-35. PMID: 7648281.
    View in: PubMed
  191. Shankar P, Fabry J, Lieberman J. A simple method to selectively expand HIV-1 specific cytotoxic T lymphocytes in vitro. Immunol Invest. 1995 Mar; 24(3):489-97. PMID: 7790045.
    View in: PubMed
  192. Lieberman J, Fabry JA, Shankar P, Beckett L, Skolnik PR. Ex vivo expansion of HIV type 1-specific cytolytic T cells from HIV type 1-seropositive subjects. AIDS Res Hum Retroviruses. 1995 Feb; 11(2):257-71. PMID: 7742040.
    View in: PubMed
  193. McFarland TA, Ardman B, Manjunath N, Fabry JA, Lieberman J. CD43 diminishes susceptibility to T lymphocyte-mediated cytolysis. J Immunol. 1995 Feb 01; 154(3):1097-104. PMID: 7822786.
    View in: PubMed
  194. Schwartz D, Sharma U, Busch M, Weinhold K, Matthews T, Lieberman J, Birx D, Farzedagen H, Margolick J, Quinn T, et al. Absence of recoverable infectious virus and unique immune responses in an asymptomatic HIV+ long-term survivor. AIDS Res Hum Retroviruses. 1994 Dec; 10(12):1703-11. PMID: 7888230.
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  195. Lieberman J, Buchsbaum RJ. Using T cells to treat B-cell cancers. N Engl J Med. 1994 Apr 28; 330(17):1231-3. PMID: 8139635.
    View in: PubMed
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