Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Judy Lieberman, M.D., PH.D.

Title
Institution
Department
Address
Phone
Fax

Mentoring
completed student projects
Synthesis of a bifunctional chimera: Discriminate delivery of siRNA to CD4+ cells by fusion to RNA-based aptamers
Summer, 01/02/07 - 08/15/07
Understanding the role of tumor-derived extracellular vesicles in breast cancer metastasis
Summer, 06/05/15 - 08/28/15

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01AI145862 (LIEBERMAN, JUDY) Jun 19, 2019 - May 31, 2024
    NIH/NIAID
    Decidual NK response to infection
    Role: Principal Investigator
  2. R21AI131632 (GAZZINELLI, RICARDO) Jan 9, 2018 - Dec 31, 2019
    NIH/NIAID
    Killing of P. vivax infected reticulocytes by cytotoxic T cells
    Role: Co-Principal Investigator
  3. R21HD087689 (STROMINGER, JACK L) Mar 4, 2016 - Feb 28, 2018
    NIH/NICHD
    Control of placental infection by decidual NK cell secreted granulysin
    Role: Principal Investigator
  4. R01AI116577 (LIEBERMAN, JUDY) Mar 1, 2016 - Feb 28, 2021
    NIH/NIAID
    Granzyme and Granulysin Mediated Death of Trypanosoma cruzi
    Role: Co-Principal Investigator
  5. R01AI123265 (LIEBERMAN, JUDY) Feb 15, 2016 - Jan 31, 2021
    NIH/NIAID
    Granulysin, Granzymes and Perforin in Bacterial Immune Defense
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dotiwala F, Lieberman J. Granulysin: killer lymphocyte safeguard against microbes. Curr Opin Immunol. 2019 May 18; 60:19-29. PMID: 31112765.
    Citations:    
  2. Vu LT, Peng B, Zhang DX, Ma V, Mathey-Andrews CA, Lam CK, Kiomourtzis T, Jin J, McReynolds L, Huang L, Grimson A, Cho WC, Lieberman J, Le MT. Tumor-secreted extracellular vesicles promote the activation of cancer-associated fibroblasts via the transfer of microRNA-125b. J Extracell Vesicles. 2019; 8(1):1599680. PMID: 31044053.
    Citations:    
  3. Trifonova RT, Bollman B, Barteneva NS, Lieberman J. Myeloid Cells in Intact Human Cervical Explants Capture HIV and Can Transmit It to CD4 T Cells. Front Immunol. 2018; 9:2719. PMID: 30532754.
    Citations:    
  4. Lieberman J. Unveiling the RNA World. N Engl J Med. 2018 09 27; 379(13):1278-1280. PMID: 30200806.
    Citations:    Fields:    Translation:Humans
  5. Junqueira C, Barbosa CRR, Costa PAC, Teixeira-Carvalho A, Castro G, Sen Santara S, Barbosa RP, Dotiwala F, Pereira DB, Antonelli LR, Lieberman J, Gazzinelli RT. Cytotoxic CD8+ T cells recognize and kill Plasmodium vivax-infected reticulocytes. Nat Med. 2018 09; 24(9):1330-1336. PMID: 30038217.
    Citations:    Fields:    
  6. Meyer SE, Muench DE, Rogers AM, Newkold TJ, Orr E, O'Brien E, Perentesis JP, Doench JG, Lal A, Morris PJ, Thomas CJ, Lieberman J, McGlinn E, Aronow BJ, Salomonis N, Grimes HL. miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential. J Exp Med. 2018 08 06; 215(8):2115-2136. PMID: 29997117.
    Citations:    Fields:    
  7. Liu X, Fu R, Pan Y, Meza-Sosa KF, Zhang Z, Lieberman J. PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs. Cell. 2018 06 28; 174(1):187-201.e12. PMID: 29779946.
    Citations: 1     Fields:    
  8. Ruan J, Xia S, Liu X, Lieberman J, Wu H. Cryo-EM structure of the gasdermin A3 membrane pore. Nature. 2018 05; 557(7703):62-67. PMID: 29695864.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  9. Clayton KL, Collins DR, Lengieza J, Ghebremichael M, Dotiwala F, Lieberman J, Walker BD. Resistance of HIV-infected macrophages to CD8+ T lymphocyte-mediated killing drives activation of the immune system. Nat Immunol. 2018 05; 19(5):475-486. PMID: 29670239.
    Citations:    Fields:    
  10. Lieberman J. Tapping the RNA world for therapeutics. Nat Struct Mol Biol. 2018 May; 25(5):357-364. PMID: 29662218.
    Citations: 3     Fields:    
  11. Doan M, Vorobjev I, Rees P, Filby A, Wolkenhauer O, Goldfeld AE, Lieberman J, Barteneva N, Carpenter AE, Hennig H. Diagnostic Potential of Imaging Flow Cytometry. Trends Biotechnol. 2018 07; 36(7):649-652. PMID: 29395345.
    Citations:    Fields:    
  12. Kedmi R, Veiga N, Ramishetti S, Goldsmith M, Rosenblum D, Dammes N, Hazan-Halevy I, Nahary L, Leviatan-Ben-Arye S, Harlev M, Behlke M, Benhar I, Lieberman J, Peer D. A modular platform for targeted RNAi therapeutics. Nat Nanotechnol. 2018 03; 13(3):214-219. PMID: 29379205.
    Citations: 2     Fields:    
  13. Sula Karreci E, Eskandari SK, Dotiwala F, Routray SK, Kurdi AT, Assaker JP, Luckyanchykov P, Mihali AB, Maarouf O, Borges TJ, Alkhudhayri A, Patel KR, Radwan A, Ghobrial I, McGrath M, Chandraker A, Riella LV, Elyaman W, Abdi R, Lieberman J, Azzi J. Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation. JCI Insight. 2017 11 02; 2(21). PMID: 29093262.
    Citations:    Fields:    
  14. Dotiwala F, Sen Santara S, Binker-Cosen AA, Li B, Chandrasekaran S, Lieberman J. Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program. Cell. 2017 Nov 16; 171(5):1125-1137.e11. PMID: 29107333.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  15. Chan S, Sridhar P, Kirchner R, Lock YJ, Herbert Z, Buonamici S, Smith P, Lieberman J, Petrocca F. Basal-A Triple-Negative Breast Cancer Cells Selectively Rely on RNA Splicing for Survival. Mol Cancer Ther. 2017 Dec; 16(12):2849-2861. PMID: 28878028.
    Citations:    Fields:    Translation:HumansCells
  16. Deruaz M, Murooka TT, Ji S, Gavin MA, Vrbanac VD, Lieberman J, Tager AM, Mempel TR, Luster AD. Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa. JCI Insight. 2017 04 06; 2(7):e88533. PMID: 28405607.
    Citations: 1     Fields:    
  17. Liu X, Lieberman J. A Mechanistic Understanding of Pyroptosis: The Fiery Death Triggered by Invasive Infection. Adv Immunol. 2017; 135:81-117. PMID: 28826530.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  18. Su S, Liao J, Liu J, Huang D, He C, Chen F, Yang L, Wu W, Chen J, Lin L, Zeng Y, Ouyang N, Cui X, Yao H, Su F, Huang JD, Lieberman J, Liu Q, Song E. Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer. Cell Res. 2017 Apr; 27(4):461-482. PMID: 28290464.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  19. Liu X, Lieberman J. How ICE lights the pyroptosis fire. Cell Death Differ. 2017 02; 24(2):197-199. PMID: 28060375.
    Citations:    Fields:    Translation:Humans
  20. Liu X, Zhang Z, Ruan J, Pan Y, Magupalli VG, Wu H, Lieberman J. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 2016 07 07; 535(7610):153-8. PMID: 27383986.
    Citations: 113     Fields:    Translation:HumansAnimalsCells
  21. Wheeler LA, Trifonova RT, Vrbanac V, Barteneva NS, Liu X, Bollman B, Onofrey L, Mulik S, Ranjbar S, Luster AD, Tager AM, Lieberman J. TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice. Cell Rep. 2016 05 24; 15(8):1715-27. PMID: 27184854.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  22. Boulias K, Lieberman J, Greer EL. An Epigenetic Clock Measures Accelerated Aging in Treated HIV Infection. Mol Cell. 2016 04 21; 62(2):153-155. PMID: 27105110.
    Citations: 2     Fields:    Translation:HumansCells
  23. Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, Thomas M, Lieberman J, McInerney GM, Ivanov P, Anderson P. G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. J Cell Biol. 2016 Mar 28; 212(7):845-60. PMID: 27022092.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  24. Basu R, Whitlock BM, Husson J, Le Floc'h A, Jin W, Oyler-Yaniv A, Dotiwala F, Giannone G, Hivroz C, Biais N, Lieberman J, Kam LC, Huse M. Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing. Cell. 2016 Mar 24; 165(1):100-110. PMID: 26924577.
    Citations: 26     Fields:    Translation:AnimalsCells
  25. Dotiwala F, Mulik S, Polidoro RB, Ansara JA, Burleigh BA, Walch M, Gazzinelli RT, Lieberman J. Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites. Nat Med. 2016 Feb; 22(2):210-6. PMID: 26752517.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  26. Tan SM, Lieberman J. Capture and Identification of miRNA Targets by Biotin Pulldown and RNA-seq. Methods Mol Biol. 2016; 1358:211-28. PMID: 26463386.
    Citations: 2     Fields:    
  27. Weinstein S, Toker IA, Emmanuel R, Ramishetti S, Hazan-Halevy I, Rosenblum D, Goldsmith M, Abraham A, Benjamini O, Bairey O, Raanani P, Nagler A, Lieberman J, Peer D. Harnessing RNAi-based nanomedicines for therapeutic gene silencing in B-cell malignancies. Proc Natl Acad Sci U S A. 2016 Jan 05; 113(1):E16-22. PMID: 26699502.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  28. Wittrup A, Lieberman J. Knocking down disease: a progress report on siRNA therapeutics. Nat Rev Genet. 2015 Sep; 16(9):543-52. PMID: 26281785.
    Citations: 91     Fields:    Translation:HumansAnimals
  29. Gilboa-Geffen A, Hamar P, Le MT, Wheeler LA, Trifonova R, Petrocca F, Wittrup A, Lieberman J. Gene Knockdown by EpCAM Aptamer-siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells. Mol Cancer Ther. 2015 Oct; 14(10):2279-91. PMID: 26264278.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  30. Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J. Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown. Nat Biotechnol. 2015 Aug; 33(8):870-6. PMID: 26192320.
    Citations: 35     Fields:    Translation:HumansCells
  31. Navarro F, Lieberman J. miR-34 and p53: New Insights into a Complex Functional Relationship. PLoS One. 2015; 10(7):e0132767. PMID: 26177460.
    Citations: 27     Fields:    Translation:HumansCells
  32. Lieberman J. Manipulating the in vivo immune response by targeted gene knockdown. Curr Opin Immunol. 2015 Aug; 35:63-72. PMID: 26149459.
    Citations: 2     Fields:    Translation:HumansAnimals
  33. Dotiwala F, Fellay I, Filgueira L, Martinvalet D, Lieberman J, Walch M. A High Yield and Cost-efficient Expression System of Human Granzymes in Mammalian Cells. J Vis Exp. 2015 Jun 10; (100):e52911. PMID: 26132420.
    Citations: 1     Fields:    Translation:HumansCells
  34. O'Day E, Le MT, Imai S, Tan SM, Kirchner R, Arthanari H, Hofmann O, Wagner G, Lieberman J. An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates. J Biol Chem. 2015 Jul 17; 290(29):17909-22. PMID: 26045559.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  35. Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J. Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes. Cell. 2015 May 21; 161(5):1229. PMID: 28910642.
    Citations: 2     Fields:    
  36. Thomas MP, Liu X, Whangbo J, McCrossan G, Sanborn KB, Basar E, Walch M, Lieberman J. Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2. Cell Rep. 2015 May 19; 11(7):1079-89. PMID: 25959823.
    Citations: 20     Fields:    Translation:HumansCells
  37. Sharei A, Trifonova R, Jhunjhunwala S, Hartoularos GC, Eyerman AT, Lytton-Jean A, Angin M, Sharma S, Poceviciute R, Mao S, Heimann M, Liu S, Talkar T, Khan OF, Addo M, von Andrian UH, Anderson DG, Langer R, Lieberman J, Jensen KF. Ex vivo cytosolic delivery of functional macromolecules to immune cells. PLoS One. 2015; 10(4):e0118803. PMID: 25875117.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  38. Luo ML, Gong C, Chen CH, Hu H, Huang P, Zheng M, Yao Y, Wei S, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation. Cell Rep. 2015 Apr 07; 11(1):111-24. PMID: 25818297.
    Citations: 20     Fields:    Translation:HumansCells
  39. Hata A, Lieberman J. Dysregulation of microRNA biogenesis and gene silencing in cancer. Sci Signal. 2015 Mar 17; 8(368):re3. PMID: 25783160.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  40. Lieberman J, Sharp PA. Harnessing RNA interference for therapy: the silent treatment. JAMA. 2015 Mar 24-31; 313(12):1207-8. PMID: 25803342.
    Citations: 2     Fields:    Translation:Humans
  41. Le MT, Hamar P, Guo C, Basar E, Perdigão-Henriques R, Balaj L, Lieberman J. miR-200-containing extracellular vesicles promote breast cancer cell metastasis. J Clin Invest. 2014 Dec; 124(12):5109-28. PMID: 25401471.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  42. Ivanov P, O'Day E, Emara MM, Wagner G, Lieberman J, Anderson P. G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18201-6. PMID: 25404306.
    Citations: 44     Fields:    Translation:HumansCells
  43. Wheeler LA, Lieberman J. Developing an Effective Rectal Microbicide: Inhibiting HIV Transmission in Human Colorectal Tissue and Humanized Mice with CD4 Aptamer-siRNA Chimeras. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A206. PMID: 25357578.
    Citations:    
  44. Wheeler LA, Lieberman J. Inhibiting the Host Exonuclease TREX1 Induces a Localized and Protective Host Interferon Response against Acute HIV Infection In Vivo. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A41. PMID: 25357849.
    Citations:    
  45. Tan SM, Kirchner R, Jin J, Hofmann O, McReynolds L, Hide W, Lieberman J. Sequencing of captive target transcripts identifies the network of regulated genes and functions of primate-specific miR-522. Cell Rep. 2014 Aug 21; 8(4):1225-39. PMID: 25131211.
    Citations: 18     Fields:    Translation:HumansCells
  46. Tay Y, Tan SM, Karreth FA, Lieberman J, Pandolfi PP. Characterization of dual PTEN and p53-targeting microRNAs identifies microRNA-638/Dnm2 as a two-hit oncogenic locus. Cell Rep. 2014 Aug 07; 8(3):714-22. PMID: 25088422.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  47. Walch M, Dotiwala F, Mulik S, Thiery J, Kirchhausen T, Clayberger C, Krensky AM, Martinvalet D, Lieberman J. Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes. Cell. 2014 Jun 05; 157(6):1309-23. PMID: 24906149.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  48. Luo ML, Gong C, Chen CH, Lee DY, Hu H, Huang P, Yao Y, Guo W, Reinhardt F, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP. Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer. Cancer Res. 2014 Jul 01; 74(13):3603-16. PMID: 24786790.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  49. Thomas MP, Whangbo J, McCrossan G, Deutsch AJ, Martinod K, Walch M, Lieberman J. Leukocyte protease binding to nucleic acids promotes nuclear localization and cleavage of nucleic acid binding proteins. J Immunol. 2014 Jun 01; 192(11):5390-7. PMID: 24771851.
    Citations: 8     Fields:    Translation:HumansCellsCTClinical Trials
  50. Trifonova RT, Lieberman J, van Baarle D. Distribution of immune cells in the human cervix and implications for HIV transmission. Am J Reprod Immunol. 2014 Mar; 71(3):252-64. PMID: 24410939.
    Citations: 13     Fields:    Translation:HumansCells
  51. Thiery J, Lieberman J. Perforin: a key pore-forming protein for immune control of viruses and cancer. Subcell Biochem. 2014; 80:197-220. PMID: 24798013.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  52. Huang L, Lieberman J. Production of highly potent recombinant siRNAs in Escherichia coli. Nat Protoc. 2013 Dec; 8(12):2325-36. PMID: 24177290.
    Citations: 6     Fields:    Translation:HumansCells
  53. Tuli A, Thiery J, James AM, Michelet X, Sharma M, Garg S, Sanborn KB, Orange JS, Lieberman J, Brenner MB. Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. Mol Biol Cell. 2013 Dec; 24(23):3721-35. PMID: 24088571.
    Citations: 21     Fields:    Translation:HumansCells
  54. Petrocca F, Altschuler G, Tan SM, Mendillo ML, Yan H, Jerry DJ, Kung AL, Hide W, Ince TA, Lieberman J. A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells. Cancer Cell. 2013 Aug 12; 24(2):182-96. PMID: 23948298.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  55. Thomas MP, Lieberman J. Live or let die: posttranscriptional gene regulation in cell stress and cell death. Immunol Rev. 2013 May; 253(1):237-52. PMID: 23550650.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  56. Wheeler LA, Vrbanac V, Trifonova R, Brehm MA, Gilboa-Geffen A, Tanno S, Greiner DL, Luster AD, Tager AM, Lieberman J. Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras. Mol Ther. 2013 Jul; 21(7):1378-89. PMID: 23629001.
    Citations: 24     Fields:    Translation:HumansAnimals
  57. Lieberman J, Slack F, Pandolfi PP, Chinnaiyan A, Agami R, Mendell JT. Noncoding RNAs and cancer. Cell. 2013 Mar 28; 153(1):9-10. PMID: 23781554.
    Citations: 18     Fields:    Translation:HumansAnimals
  58. Huang L, Jin J, Deighan P, Kiner E, McReynolds L, Lieberman J. Efficient and specific gene knockdown by small interfering RNAs produced in bacteria. Nat Biotechnol. 2013 Apr; 31(4):350-6. PMID: 23475073.
    Citations: 15     Fields:    Translation:HumansCells
  59. Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N. Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nat Immunol. 2013 Feb; 14(2):179-85. PMID: 23263557.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  60. Yan N, Lieberman J. SAMHD1 does it again, now in resting T cells. Nat Med. 2012 Nov; 18(11):1611-2. PMID: 23135508.
    Citations: 5     Fields:    Translation:HumansCells
  61. Rajani DK, Walch M, Martinvalet D, Thomas MP, Lieberman J. Alterations in RNA processing during immune-mediated programmed cell death. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8688-93. PMID: 22589304.
    Citations: 10     Fields:    Translation:HumansCells
  62. Yao YD, Sun TM, Huang SY, Dou S, Lin L, Chen JN, Ruan JB, Mao CQ, Yu FY, Zeng MS, Zang JY, Liu Q, Su FX, Zhang P, Lieberman J, Wang J, Song E. Targeted delivery of PLK1-siRNA by ScFv suppresses Her2+ breast cancer growth and metastasis. Sci Transl Med. 2012 Apr 18; 4(130):130ra48. PMID: 22517885.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  63. Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A. Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. J Biol Chem. 2012 Feb 03; 287(6):3976-86. PMID: 22158624.
    Citations: 34     Fields:    Translation:Humans
  64. Lal A, Thomas MP, Altschuler G, Navarro F, O'Day E, Li XL, Concepcion C, Han YC, Thiery J, Rajani DK, Deutsch A, Hofmann O, Ventura A, Hide W, Lieberman J. Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet. 2011 Nov; 7(11):e1002363. PMID: 22102825.
    Citations: 96     Fields:    Translation:HumansCells
  65. Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L, Provero P, Di Cunto F, Lieberman J, Rigoutsos I, Pandolfi PP. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell. 2011 Oct 14; 147(2):344-57. PMID: 22000013.
    Citations: 308     Fields:    Translation:HumansAnimalsCells
  66. Le MT, Shyh-Chang N, Khaw SL, Chin L, Teh C, Tay J, O'Day E, Korzh V, Yang H, Lal A, Lieberman J, Lodish HF, Lim B. Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet. 2011 Sep; 7(9):e1002242. PMID: 21935352.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  67. Lakhashe SK, Velu V, Sciaranghella G, Siddappa NB, Dipasquale JM, Hemashettar G, Yoon JK, Rasmussen RA, Yang F, Lee SJ, Montefiori DC, Novembre FJ, Villinger F, Amara RR, Kahn M, Hu SL, Li S, Li Z, Frankel FR, Robert-Guroff M, Johnson WE, Lieberman J, Ruprecht RM. Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges. Vaccine. 2011 Aug 05; 29(34):5611-22. PMID: 21693155.
    Citations: 19     Fields:    Translation:AnimalsCellsPHPublic Health
  68. Thiery J, Keefe D, Boulant S, Boucrot E, Walch M, Martinvalet D, Goping IS, Bleackley RC, Kirchhausen T, Lieberman J. Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nat Immunol. 2011 Jun 19; 12(8):770-7. PMID: 21685908.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  69. Wheeler LA, Trifonova R, Vrbanac V, Basar E, McKernan S, Xu Z, Seung E, Deruaz M, Dudek T, Einarsson JI, Yang L, Allen TM, Luster AD, Tager AM, Dykxhoorn DM, Lieberman J. Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. J Clin Invest. 2011 Jun; 121(6):2401-12. PMID: 21576818.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  70. Yan N, O'Day E, Wheeler LA, Engelman A, Lieberman J. HIV DNA is heavily uracilated, which protects it from autointegration. Proc Natl Acad Sci U S A. 2011 May 31; 108(22):9244-9. PMID: 21576478.
    Citations: 28     Fields:    Translation:HumansCells
  71. Whitney JB, Mirshahidi S, Lim SY, Goins L, Ibegbu CC, Anderson DC, Raybourne RB, Frankel FR, Lieberman J, Ruprecht RM. Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV. J Immune Based Ther Vaccines. 2011 Jan 18; 9:2. PMID: 21244649.
    Citations: 5     
  72. Yan N, Lieberman J. Gaining a foothold: how HIV avoids innate immune recognition. Curr Opin Immunol. 2011 Feb; 23(1):21-8. PMID: 21123040.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  73. Petrocca F, Lieberman J. Promise and challenge of RNA interference-based therapy for cancer. J Clin Oncol. 2011 Feb 20; 29(6):747-54. PMID: 21079135.
    Citations: 38     Fields:    Translation:Humans
  74. Thomas M, Lieberman J, Lal A. Desperately seeking microRNA targets. Nat Struct Mol Biol. 2010 Oct; 17(10):1169-74. PMID: 20924405.
    Citations: 200     Fields:    Translation:HumansAnimalsCells
  75. Yan N, Regalado-Magdos AD, Stiggelbout B, Lee-Kirsch MA, Lieberman J. The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1. Nat Immunol. 2010 Nov; 11(11):1005-13. PMID: 20871604.
    Citations: 190     Fields:    Translation:HumansAnimalsCells
  76. Navarro F, Lieberman J. Small RNAs guide hematopoietic cell differentiation and function. J Immunol. 2010 Jun 01; 184(11):5939-47. PMID: 20483778.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  77. Thiery J, Walch M, Jensen DK, Martinvalet D, Lieberman J. Isolation of cytotoxic T cell and NK granules and purification of their effector proteins. Curr Protoc Cell Biol. 2010 Jun; Chapter 3:Unit3.37. PMID: 20521234.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  78. Lieberman J. Anatomy of a murder: how cytotoxic T cells and NK cells are activated, develop, and eliminate their targets. Immunol Rev. 2010 May; 235(1):5-9. PMID: 20536551.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  79. Lieberman J. Granzyme A activates another way to die. Immunol Rev. 2010 May; 235(1):93-104. PMID: 20536557.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  80. Niland B, Miklossy G, Banki K, Biddison WE, Casciola-Rosen L, Rosen A, Martinvalet D, Lieberman J, Perl A. Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients. J Immunol. 2010 Apr 01; 184(7):4025-32. PMID: 20194725.
    Citations: 7     Fields:    Translation:HumansCells
  81. Thiery J, Keefe D, Saffarian S, Martinvalet D, Walch M, Boucrot E, Kirchhausen T, Lieberman J. Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis. Blood. 2010 Feb 25; 115(8):1582-93. PMID: 20038786.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  82. Chan MC, Hilyard AC, Wu C, Davis BN, Hill NS, Lal A, Lieberman J, Lagna G, Hata A. Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J. 2010 Feb 03; 29(3):559-73. PMID: 20019669.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  83. Lieberman J. Micromanaging cancer. N Engl J Med. 2009 Oct 08; 361(15):1500-1. PMID: 19812408.
    Citations: 3     Fields:    Translation:Humans
  84. Dykxhoorn DM, Wu Y, Xie H, Yu F, Lal A, Petrocca F, Martinvalet D, Song E, Lim B, Lieberman J. miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS One. 2009 Sep 29; 4(9):e7181. PMID: 19787069.
    Citations: 147     Fields:    Translation:AnimalsCells
  85. Lal A, Navarro F, Maher CA, Maliszewski LE, Yan N, O'Day E, Chowdhury D, Dykxhoorn DM, Tsai P, Hofmann O, Becker KG, Gorospe M, Hide W, Lieberman J. miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell. 2009 Sep 11; 35(5):610-25. PMID: 19748357.
    Citations: 269     Fields:    Translation:HumansCells
  86. Petrocca F, Lieberman J. Micromanipulating cancer: microRNA-based therapeutics? RNA Biol. 2009 Jul-Aug; 6(3):335-40. PMID: 19535911.
    Citations: 13     Fields:    Translation:HumansAnimals
  87. Navarro F, Gutman D, Meire E, Cáceres M, Rigoutsos I, Bentwich Z, Lieberman J. miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53. Blood. 2009 Sep 03; 114(10):2181-92. PMID: 19584398.
    Citations: 60     Fields:    Translation:HumansCells
  88. Ahmed F, Friend S, George TC, Barteneva N, Lieberman J. Numbers matter: quantitative and dynamic analysis of the formation of an immunological synapse using imaging flow cytometry. J Immunol Methods. 2009 Aug 15; 347(1-2):79-86. PMID: 19524586.
    Citations: 10     Fields:    Translation:HumansCells
  89. Zhu P, Martinvalet D, Chowdhury D, Zhang D, Schlesinger A, Lieberman J. The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1. Blood. 2009 Aug 06; 114(6):1205-16. PMID: 19506301.
    Citations: 15     Fields:    Translation:HumansCells
  90. Glimcher LH, Lieberman J. Harvard's women four years later. Nat Immunol. 2009 Jun; 10(6):559-61. PMID: 19448653.
    Citations: 2     Fields:    Translation:Humans
  91. Lal A, Pan Y, Navarro F, Dykxhoorn DM, Moreau L, Meire E, Bentwich Z, Lieberman J, Chowdhury D. miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells. Nat Struct Mol Biol. 2009 May; 16(5):492-8. PMID: 19377482.
    Citations: 111     Fields:    Translation:HumansCells
  92. Yan N, Cherepanov P, Daigle JE, Engelman A, Lieberman J. The SET complex acts as a barrier to autointegration of HIV-1. PLoS Pathog. 2009 Mar; 5(3):e1000327. PMID: 19266025.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  93. Wu Y, Navarro F, Lal A, Basar E, Pandey RK, Manoharan M, Feng Y, Lee SJ, Lieberman J, Palliser D. Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene. Cell Host Microbe. 2009 Jan 22; 5(1):84-94. PMID: 19154990.
    Citations: 27     Fields:    Translation:AnimalsCells
  94. Petrocca F, Lieberman J. Micromanagers of immune cell fate and function. Adv Immunol. 2009; 102:227-44. PMID: 19477322.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  95. Petrocca F, Lieberman J. RIG-ing an antitumor response. Nat Med. 2008 Nov; 14(11):1152-3. PMID: 18989278.
    Citations: 2     Fields:    Translation:HumansAnimals
  96. Shun MC, Botbol Y, Li X, Di Nunzio F, Daigle JE, Yan N, Lieberman J, Lavigne M, Engelman A. Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity. J Virol. 2008 Dec; 82(23):11555-67. PMID: 18799576.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  97. Grant RM, Hamer D, Hope T, Johnston R, Lange J, Lederman MM, Lieberman J, Miller CJ, Moore JP, Mosier DE, Richman DD, Schooley RT, Springer MS, Veazey RS, Wainberg MA. Whither or wither microbicides? Science. 2008 Jul 25; 321(5888):532-4. PMID: 18653884.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  98. Chowdhury D, Xu X, Zhong X, Ahmed F, Zhong J, Liao J, Dykxhoorn DM, Weinstock DM, Pfeifer GP, Lieberman J. A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Mol Cell. 2008 Jul 11; 31(1):33-46. PMID: 18614045.
    Citations: 88     Fields:    Translation:HumansCells
  99. Martinvalet D, Dykxhoorn DM, Ferrini R, Lieberman J. Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death. Cell. 2008 May 16; 133(4):681-92. PMID: 18485875.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  100. Lal A, Kim HH, Abdelmohsen K, Kuwano Y, Pullmann R, Srikantan S, Subrahmanyam R, Martindale JL, Yang X, Ahmed F, Navarro F, Dykxhoorn D, Lieberman J, Gorospe M. p16(INK4a) translation suppressed by miR-24. PLoS One. 2008 Mar 26; 3(3):e1864. PMID: 18365017.
    Citations: 101     Fields:    Translation:HumansCells
  101. Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ. Identification of host proteins required for HIV infection through a functional genomic screen. Science. 2008 Feb 15; 319(5865):921-6. PMID: 18187620.
    Citations: 642     Fields:    Translation:HumansCells
  102. Chowdhury D, Lieberman J. Death by a thousand cuts: granzyme pathways of programmed cell death. Annu Rev Immunol. 2008; 26:389-420. PMID: 18304003.
    Citations: 143     Fields:    Translation:HumansAnimalsCells
  103. Dykxhoorn DM, Chowdhury D, Lieberman J. RNA interference and cancer: endogenous pathways and therapeutic approaches. Adv Exp Med Biol. 2008; 615:299-329. PMID: 18437900.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  104. Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, Huang Y, Hu X, Su F, Lieberman J, Song E. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell. 2007 Dec 14; 131(6):1109-23. PMID: 18083101.
    Citations: 704     Fields:    Translation:HumansAnimalsCells
  105. Jiang S, Rasmussen RA, Nolan KM, Frankel FR, Lieberman J, McClure HM, Williams KM, Babu US, Raybourne RB, Strobert E, Ruprecht RM. Live attenuated Listeria monocytogenes expressing HIV Gag: immunogenicity in rhesus monkeys. Vaccine. 2007 Oct 16; 25(42):7470-9. PMID: 17854955.
    Citations: 15     Fields:    Translation:AnimalsCells
  106. Lee-Kirsch MA, Gong M, Chowdhury D, Senenko L, Engel K, Lee YA, de Silva U, Bailey SL, Witte T, Vyse TJ, Kere J, Pfeiffer C, Harvey S, Wong A, Koskenmies S, Hummel O, Rohde K, Schmidt RE, Dominiczak AF, Gahr M, Hollis T, Perrino FW, Lieberman J, Hübner N. Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet. 2007 Sep; 39(9):1065-7. PMID: 17660818.
    Citations: 205     Fields:    Translation:HumansCells
  107. de Fougerolles A, Vornlocher HP, Maraganore J, Lieberman J. Interfering with disease: a progress report on siRNA-based therapeutics. Nat Rev Drug Discov. 2007 Jun; 6(6):443-53. PMID: 17541417.
    Citations: 282     Fields:    Translation:Humans
  108. Lee-Kirsch MA, Chowdhury D, Harvey S, Gong M, Senenko L, Engel K, Pfeiffer C, Hollis T, Gahr M, Perrino FW, Lieberman J, Hubner N. A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus. J Mol Med (Berl). 2007 May; 85(5):531-7. PMID: 17440703.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  109. Pipkin ME, Lieberman J. Delivering the kiss of death: progress on understanding how perforin works. Curr Opin Immunol. 2007 Jun; 19(3):301-8. PMID: 17433871.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  110. Peer D, Zhu P, Carman CV, Lieberman J, Shimaoka M. Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):4095-100. PMID: 17360483.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  111. Ranjbar S, Tsytsykova AV, Lee SK, Rajsbaum R, Falvo JV, Lieberman J, Shankar P, Goldfeld AE. NFAT5 regulates HIV-1 in primary monocytes via a highly conserved long terminal repeat site. PLoS Pathog. 2006 Dec; 2(12):e130. PMID: 17173480.
    Citations: 20     Fields:    Translation:HumansCells
  112. Dykxhoorn DM, Lieberman J. Knocking down disease with siRNAs. Cell. 2006 Jul 28; 126(2):231-5. PMID: 16873051.
    Citations: 44     Fields:    Translation:HumansAnimals
  113. Dykxhoorn DM, Lieberman J. Silencing viral infection. PLoS Med. 2006 Jul; 3(7):e242. PMID: 16848617.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  114. Chowdhury D, Beresford PJ, Zhu P, Zhang D, Sung JS, Demple B, Perrino FW, Lieberman J. The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Mol Cell. 2006 Jul 07; 23(1):133-42. PMID: 16818237.
    Citations: 78     Fields:    Translation:HumansCells
  115. Dykxhoorn DM, Schlehuber LD, London IM, Lieberman J. Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5953-8. PMID: 16585504.
    Citations: 16     Fields:    Translation:HumansCells
  116. Dykxhoorn DM, Palliser D, Lieberman J. The silent treatment: siRNAs as small molecule drugs. Gene Ther. 2006 Mar; 13(6):541-52. PMID: 16397510.
    Citations: 76     Fields:    Translation:HumansAnimals
  117. Zhu P, Zhang D, Chowdhury D, Martinvalet D, Keefe D, Shi L, Lieberman J. Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70. EMBO Rep. 2006 Apr; 7(4):431-7. PMID: 16440001.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  118. Dykxhoorn DM, Lieberman J. Running interference: prospects and obstacles to using small interfering RNAs as small molecule drugs. Annu Rev Biomed Eng. 2006; 8:377-402. PMID: 16834561.
    Citations: 28     Fields:    Translation:HumansAnimals
  119. Chowdhury D, Keogh MC, Ishii H, Peterson CL, Buratowski S, Lieberman J. gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell. 2005 Dec 09; 20(5):801-9. PMID: 16310392.
    Citations: 159     Fields:    Translation:HumansAnimalsCells
  120. Palliser D, Chowdhury D, Wang QY, Lee SJ, Bronson RT, Knipe DM, Lieberman J. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature. 2006 Jan 05; 439(7072):89-94. PMID: 16306938.
    Citations: 107     Fields:    Translation:AnimalsCells
  121. Keogh MC, Kim JA, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, Greenblatt JF, Krogan NJ. A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature. 2006 Jan 26; 439(7075):497-501. PMID: 16299494.
    Citations: 179     Fields:    Translation:AnimalsCells
  122. Keefe D, Shi L, Feske S, Massol R, Navarro F, Kirchhausen T, Lieberman J. Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. Immunity. 2005 Sep; 23(3):249-62. PMID: 16169498.
    Citations: 87     Fields:    Translation:HumansCells
  123. Feng H, Zhang D, Palliser D, Zhu P, Cai S, Schlesinger A, Maliszewski L, Lieberman J. Listeria-infected myeloid dendritic cells produce IFN-beta, priming T cell activation. J Immunol. 2005 Jul 01; 175(1):421-32. PMID: 15972676.
    Citations: 29     Fields:    Translation:AnimalsCells
  124. Liu L, Xu Z, Fuhlbrigge RC, Peña-Cruz V, Lieberman J, Kupper TS. Vaccinia virus induces strong immunoregulatory cytokine production in healthy human epidermal keratinocytes: a novel strategy for immune evasion. J Virol. 2005 Jun; 79(12):7363-70. PMID: 15919891.
    Citations: 23     Fields:    Translation:HumansCells
  125. Song E, Zhu P, Lee SK, Chowdhury D, Kussman S, Dykxhoorn DM, Feng Y, Palliser D, Weiner DB, Shankar P, Marasco WA, Lieberman J. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol. 2005 Jun; 23(6):709-17. PMID: 15908939.
    Citations: 228     Fields:    Translation:HumansAnimalsCells
  126. Shi L, Keefe D, Durand E, Feng H, Zhang D, Lieberman J. Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis. J Immunol. 2005 May 01; 174(9):5456-61. PMID: 15843543.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  127. Lee SK, Dykxhoorn DM, Kumar P, Ranjbar S, Song E, Maliszewski LE, François-Bongarçon V, Goldfeld A, Swamy NM, Lieberman J, Shankar P. Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV. Blood. 2005 Aug 01; 106(3):818-26. PMID: 15831707.
    Citations: 42     Fields:    Translation:HumansCells
  128. Shankar P, Manjunath N, Lieberman J. The prospect of silencing disease using RNA interference. JAMA. 2005 Mar 16; 293(11):1367-73. PMID: 15769970.
    Citations: 29     Fields:    Translation:HumansAnimals
  129. Martinvalet D, Zhu P, Lieberman J. Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis. Immunity. 2005 Mar; 22(3):355-70. PMID: 15780992.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  130. Xue Y, Johnson JS, Ornelles DA, Lieberman J, Engel DA. Adenovirus protein VII functions throughout early phase and interacts with cellular proteins SET and pp32. J Virol. 2005 Feb; 79(4):2474-83. PMID: 15681448.
    Citations: 25     Fields:    Translation:HumansCells
  131. Dykxhoorn DM, Lieberman J. The silent revolution: RNA interference as basic biology, research tool, and therapeutic. Annu Rev Med. 2005; 56:401-23. PMID: 15660519.
    Citations: 64     Fields:    Translation:HumansAnimals
  132. François-Bongarcon V, Feng Y, Lee SK, Chen G, Shankar P, Liu Y, Tao X, Shao Y, Lieberman J. Cross-clade CD8 T-cell responses to HIV(IIIB) and Chinese B' and C/B' viruses in North American and Chinese HIV-seropositive donors. J Acquir Immune Defic Syndr. 2004 Dec 01; 37(4):1435-44. PMID: 15602120.
    Citations: 4     Fields:    Translation:HumansCells
  133. Hamar P, Song E, Kökény G, Chen A, Ouyang N, Lieberman J. Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14883-8. PMID: 15466709.
    Citations: 74     Fields:    Translation:AnimalsCells
  134. Ince MN, Harnisch B, Xu Z, Lee SK, Lange C, Moretta L, Lederman M, Lieberman J. Increased expression of the natural killer cell inhibitory receptor CD85j/ILT2 on antigen-specific effector CD8 T cells and its impact on CD8 T-cell function. Immunology. 2004 Aug; 112(4):531-42. PMID: 15270723.
    Citations: 17     Fields:    Translation:HumansCells
  135. Lieberman J. Tracking the killers: how should we measure CD8 T cells in HIV infection? AIDS. 2004 Jul 23; 18(11):1489-93. PMID: 15238766.
    Citations: 7     Fields:    Translation:HumansCells
  136. Lange CG, Xu Z, Patterson BK, Medvik K, Harnisch B, Asaad R, Valdez H, Lee SJ, Landay A, Lieberman J, Lederman MM. Proliferation responses to HIVp24 during antiretroviral therapy do not reflect improved immune phenotype or function. AIDS. 2004 Mar 05; 18(4):605-13. PMID: 15090765.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  137. Burton DR, Desrosiers RC, Doms RW, Feinberg MB, Gallo RC, Hahn B, Hoxie JA, Hunter E, Korber B, Landay A, Lederman MM, Lieberman J, McCune JM, Moore JP, Nathanson N, Picker L, Richman D, Rinaldo C, Stevenson M, Watkins DI, Wolinsky SM, Zack JA. Public health. A sound rationale needed for phase III HIV-1 vaccine trials. Science. 2004 Jan 16; 303(5656):316. PMID: 14726576.
    Citations: 37     Fields:    Translation:HumansCells
  138. Lieberman J, Fan Z. Nuclear war: the granzyme A-bomb. Curr Opin Immunol. 2003 Oct; 15(5):553-9. PMID: 14499264.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  139. De Groot AS, Jesdale B, Martin W, Saint Aubin C, Sbai H, Bosma A, Lieberman J, Skowron G, Mansourati F, Mayer KH. Mapping cross-clade HIV-1 vaccine epitopes using a bioinformatics approach. Vaccine. 2003 Oct 01; 21(27-30):4486-504. PMID: 14505932.
    Citations: 20     Fields:    Translation:HumansCells
  140. Wan J, Martinvalet D, Ji X, Lois C, Kaech SM, Von Andrian UH, Lieberman J, Ahmed R, Manjunath N. The Bcl-2 family pro-apoptotic molecule, BNIP3 regulates activation-induced cell death of effector cytotoxic T lymphocytes. Immunology. 2003 Sep; 110(1):10-7. PMID: 12941136.
    Citations: 8     Fields:    Translation:AnimalsCells
  141. Lieberman J, Song E, Lee SK, Shankar P. Interfering with disease: opportunities and roadblocks to harnessing RNA interference. Trends Mol Med. 2003 Sep; 9(9):397-403. PMID: 13129706.
    Citations: 14     Fields:    Translation:HumansAnimals
  142. Song E, Lee SK, Dykxhoorn DM, Novina C, Zhang D, Crawford K, Cerny J, Sharp PA, Lieberman J, Manjunath N, Shankar P. Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages. J Virol. 2003 Jul; 77(13):7174-81. PMID: 12805416.
    Citations: 74     Fields:    Translation:HumansCells
  143. Kushner N, Zhang D, Touzjian N, Essex M, Lieberman J, Lu Y. A fragment of anthrax lethal factor delivers proteins to the cytosol without requiring protective antigen. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6652-7. PMID: 12740437.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  144. Lieberman J. The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. Nat Rev Immunol. 2003 May; 3(5):361-70. PMID: 12766758.
    Citations: 123     Fields:    Translation:AnimalsCells
  145. Gu X, Laouar A, Wan J, Daheshia M, Lieberman J, Yokoyama WM, Katz HR, Manjunath N. The gp49B1 inhibitory receptor regulates the IFN-gamma responses of T cells and NK cells. J Immunol. 2003 Apr 15; 170(8):4095-101. PMID: 12682239.
    Citations: 9     Fields:    Translation:AnimalsCells
  146. Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell. 2003 Mar 07; 112(5):659-72. PMID: 12628186.
    Citations: 153     Fields:    Translation:HumansCells
  147. Song E, Lee SK, Wang J, Ince N, Ouyang N, Min J, Chen J, Shankar P, Lieberman J. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med. 2003 Mar; 9(3):347-51. PMID: 12579197.
    Citations: