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I-Cheng Ho, Ph.D., M.D.

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Overview
Dr. I-Cheng Ho's laboratory has two major research focuses.
1. Pathogenesis and translational research of rheumatoid arthritis. Ho lab is investigating how genetic/environmental risk factors contribute to the autoimmune process of rheumatoid arthritis. The lab is also identifying biomarkers and developing bioassays for predicting response to various treatments, hoping to bring personalized medicine to rheumatoid arthritis.
2. Roles of protein citrullination in regulating the function of immune and non-immune cells. Citrullination is a unique form of post-translational modification of proteins, and hypercitrullination is associated with several major risk factors of rheumatoid arthritis. Ho lab is investigating how citrullination affects the function of immune cells, such as lymphocytes, and non-immune cells, such as fibroblasts, in the context of autoimmune diseases and development.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI165967 (HO, I-CHENG) Sep 22, 2021 - Aug 31, 2023
    NIH
    Proteome-wide assessment of the impact of citrullination on the activityof transcription factors in Th2 cells
    Role: Principal Investigator
  2. R03AI155935 (HO, I-CHENG) Nov 17, 2020 - Oct 31, 2022
    NIH
    Detecting RORgt Citrullination
    Role: Principal Investigator
  3. R21AR074788 (HO, I-CHENG) Sep 7, 2018 - Aug 31, 2021
    NIH
    Utilizing the RA signature to predict TNFi response
    Role: Principal Investigator
  4. R01AR070171 (HO, I-CHENG) Sep 12, 2017 - Jul 31, 2022
    NIH
    Causes and Roles of Hypercitrullination in Preclinical Rheumatoid Arthritis
    Role: Principal Investigator
  5. R03AI097724 (HO, I-CHENG) Feb 15, 2012 - Jan 31, 2014
    NIH
    Phenotypic characterization of itm2a-deficiency in T cells
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ho CH, Silva AA, Tomita B, Weng HY, Ho IC. Differential impacts of TNFa inhibitors on the transcriptome of Th cells. Arthritis Res Ther. 2021 07 23; 23(1):199. PMID: 34301319.
    Citations:    Fields:    Translation:HumansCells
  2. Sun B, Tomita B, Salinger A, Tilvawala RR, Li L, Hakami H, Liu T, Tsoyi K, Rosas IO, Reinhardt DP, Thompson PR, Ho IC. PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis. Matrix Biol. 2021 Aug; 102:70-84. PMID: 34274450.
    Citations:    Fields:    
  3. Ho CH, Silva AA, Giles JT, Bathon JM, Solomon DH, Liao KP, Ho IC. Validation of a Bioassay for Predicting Response to Tumor Necrosis Factor Inhibitors in Rheumatoid Arthritis. Arthritis Rheumatol. 2021 06; 73(6):1086-1087. PMID: 33426780.
    Citations:    Fields:    Translation:HumansCells
  4. Tai TS, Tsao HW, Chuang WC, Liu CC, Huang YW, Oettgen P, Chuang YT, Ho IC. Ets1 regulates the differentiation and function of iNKT cells through both Pointed domain-dependent and domain-independent mechanisms. Cell Mol Immunol. 2020 11; 17(11):1198-1200. PMID: 32139882.
    Citations:    Fields:    Translation:AnimalsCells
  5. Sun B, Chang HH, Salinger A, Tomita B, Bawadekar M, Holmes CL, Shelef MA, Weerapana E, Thompson PR, Ho IC. Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination. JCI Insight. 2019 11 14; 4(22). PMID: 31723060.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  6. Yang JS, Hsu JW, Park SY, Lee SY, Li J, Bai M, Alves C, Tseng W, Michelet X, Ho IC, Hsu VW. ALDH7A1 inhibits the intracellular transport pathways during hypoxia and starvation to promote cellular energy homeostasis. Nat Commun. 2019 09 06; 10(1):4068. PMID: 31492851.
    Citations: 4     Fields:    Translation:HumansCells
  7. Chang HH, Ho CH, Tomita B, Silva AA, Sparks JA, Karlson EW, Rao DA, Lee YC, Ho IC. Utilizing a PTPN22 gene signature to predict response to targeted therapies in rheumatoid arthritis. J Autoimmun. 2019 07; 101:121-130. PMID: 31030958.
    Citations: 3     Fields:    Translation:HumansCells
  8. Sun B, Dwivedi N, Bechtel TJ, Paulsen JL, Muth A, Bawadekar M, Li G, Thompson PR, Shelef MA, Schiffer CA, Weerapana E, Ho IC. Citrullination of NF-?B p65 promotes its nuclear localization and TLR-induced expression of IL-1ß and TNFa. Sci Immunol. 2017 Jun 09; 2(12). PMID: 28783661.
    Citations: 25     Fields:    
  9. Chang HH, Liu GY, Dwivedi N, Sun B, Okamoto Y, Kinslow JD, Deane KD, Demoruelle MK, Norris JM, Thompson PR, Sparks JA, Rao DA, Karlson EW, Hung HC, Holers VM, Ho IC. A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22. JCI Insight. 2016 Oct 20; 1(17):e90045. PMID: 27777982.
    Citations: 13     Fields:    Translation:HumansCells
  10. Popp V, Gerlach K, Mott S, Turowska A, Garn H, Atreya R, Lehr HA, Ho IC, Renz H, Weigmann B, Neurath MF. Rectal Delivery of a DNAzyme That Specifically Blocks the Transcription Factor GATA3 and Reduces Colitis in Mice. Gastroenterology. 2017 01; 152(1):176-192.e5. PMID: 27639807.
    Citations:    
  11. Ho IC, Miaw SC. Regulation of IL-4 Expression in Immunity and Diseases. Adv Exp Med Biol. 2016; 941:31-77. PMID: 27734408.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  12. Xiong Y, Murphy M, Manavalan TT, Pattabiraman G, Qiu F, Chang HH, Ho IC, Medvedev AE. Endotoxin Tolerance Inhibits Lyn and c-Src Phosphorylation and Association with Toll-Like Receptor 4 but Increases Expression and Activity of Protein Phosphatases. J Innate Immun. 2016; 8(2):171-84. PMID: 26457672.
    Citations:    
  13. Chang HH, Dwivedi N, Nicholas AP, Ho IC. The W620 Polymorphism in PTPN22 Disrupts Its Interaction With Peptidylarginine Deiminase Type 4 and Enhances Citrullination and NETosis. Arthritis Rheumatol. 2015 Sep; 67(9):2323-34. PMID: 26019128.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  14. Liu CC, Lai CY, Yen WF, Lin YH, Chang HH, Tai TS, Lu YJ, Tsao HW, Ho IC, Miaw SC. Reciprocal regulation of C-Maf tyrosine phosphorylation by Tec and Ptpn22. PLoS One. 2015; 10(5):e0127617. PMID: 25993510.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  15. Liang MH, Couto MC, Duarte CC, Gall V, White P, Naides S, Schumacher HR, Hwang AS, Holers VM, Deane KD, Gupta S, Ho IC, Finckh A, Kopec J, Choi CB, Sayre EC. An Internet-based technique for the identification of persons with symptoms of inflammatory polyarthritis of less than 12 weeks. Clin Rheumatol. 2015 Mar; 34(3):465-70. PMID: 25339123.
    Citations: 2     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
  16. Tai TS, Pai SY, Ho IC. Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells. PLoS One. 2014; 9(5):e96535. PMID: 24831988.
    Citations: 8     Fields:    Translation:AnimalsCells
  17. Chang HH, Tseng W, Cui J, Costenbader K, Ho IC. Altered expression of protein tyrosine phosphatase, non-receptor type 22 isoforms in systemic lupus erythematosus. Arthritis Res Ther. 2014 Jan 17; 16(1):R14. PMID: 24433447.
    Citations: 6     Fields:    Translation:HumansCells
  18. Tsao HW, Tai TS, Tseng W, Chang HH, Grenningloh R, Miaw SC, Ho IC. Ets-1 facilitates nuclear entry of NFAT proteins and their recruitment to the IL-2 promoter. Proc Natl Acad Sci U S A. 2013 Sep 24; 110(39):15776-81. PMID: 24019486.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  19. Chang HH, Miaw SC, Tseng W, Sun YW, Liu CC, Tsao HW, Ho IC. PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis. J Immunol. 2013 Sep 01; 191(5):2134-43. PMID: 23913970.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  20. Tai TS, Pai SY, Ho IC. GATA-3 regulates the homeostasis and activation of CD8+ T cells. J Immunol. 2013 Jan 01; 190(1):428-37. PMID: 23225883.
    Citations: 22     Fields:    Translation:AnimalsCells
  21. Chang HH, Tai TS, Lu B, Iannaccone C, Cernadas M, Weinblatt M, Shadick N, Miaw SC, Ho IC. PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis. PLoS One. 2012; 7(3):e33067. PMID: 22427951.
    Citations: 17     Fields:    Translation:HumansCells
  22. Lee CG, Kwon HK, Sahoo A, Hwang W, So JS, Hwang JS, Chae CS, Kim GC, Kim JE, So HS, Hwang ES, Grenningloh R, Ho IC, Im SH. Interaction of Ets-1 with HDAC1 represses IL-10 expression in Th1 cells. J Immunol. 2012 Mar 01; 188(5):2244-53. PMID: 22266280.
    Citations:    
  23. Liang HE, Reinhardt RL, Bando JK, Sullivan BM, Ho IC, Locksley RM. Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nat Immunol. 2011 Dec 04; 13(1):58-66. PMID: 22138715.
    Citations:    
  24. Grenningloh R, Tai TS, Frahm N, Hongo TC, Chicoine AT, Brander C, Kaufmann DE, Ho IC. Ets-1 maintains IL-7 receptor expression in peripheral T cells. J Immunol. 2011 Jan 15; 186(2):969-76. PMID: 21148801.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  25. Lin BS, Tsai PY, Hsieh WY, Tsao HW, Liu MW, Grenningloh R, Wang LF, Ho IC, Miaw SC. SUMOylation attenuates c-Maf-dependent IL-4 expression. Eur J Immunol. 2010 Apr; 40(4):1174-84. PMID: 20127678.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  26. Strempel JM, Grenningloh R, Ho IC, Vercelli D. Phylogenetic and functional analysis identifies Ets-1 as a novel regulator of the Th2 cytokine gene locus. J Immunol. 2010 Feb 01; 184(3):1309-16. PMID: 20038639.
    Citations:    
  27. Zamisch M, Tian L, Grenningloh R, Xiong Y, Wildt KF, Ehlers M, Ho IC, Bosselut R. The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus. J Exp Med. 2009 Nov 23; 206(12):2685-99. PMID: 19917777.
    Citations:    
  28. Pot C, Jin H, Awasthi A, Liu SM, Lai CY, Madan R, Sharpe AH, Karp CL, Miaw SC, Ho IC, Kuchroo VK. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J Immunol. 2009 Jul 15; 183(2):797-801. PMID: 19570826.
    Citations: 219     Fields:    Translation:AnimalsCells
  29. Ho IC. m(en)TOR(ing) differentiating T helper cells. Immunity. 2009 Jun 19; 30(6):759-61. PMID: 19538925.
    Citations: 2     Fields:    Translation:AnimalsCells
  30. Pei XH, Bai F, Smith MD, Usary J, Fan C, Pai SY, Ho IC, Perou CM, Xiong Y. CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis. Cancer Cell. 2009 May 05; 15(5):389-401. PMID: 19411068.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  31. Ho IC, Tai TS, Pai SY. GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 2009 Feb; 9(2):125-35. PMID: 19151747.
    Citations: 141     Fields:    Translation:HumansAnimalsCells
  32. Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho IC, Sharpe AH, Kuchroo VK. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol. 2009 Feb; 10(2):167-75. PMID: 19098919.
    Citations: 327     Fields:    Translation:AnimalsCells
  33. Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, Mitsdoerffer M, Strom TB, Elyaman W, Ho IC, Khoury S, Oukka M, Kuchroo VK. IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol. 2008 Dec; 9(12):1347-55. PMID: 18997793.
    Citations: 449     Fields:    Translation:AnimalsCells
  34. Brunner M, Zhang M, Genin A, Ho IC, Cron RQ. A T-cell-specific CD154 transcriptional enhancer located just upstream of the promoter. Genes Immun. 2008 Oct; 9(7):640-9. PMID: 18719603.
    Citations:    
  35. Doganci A, Karwot R, Maxeiner JH, Scholtes P, Schmitt E, Neurath MF, Lehr HA, Ho IC, Finotto S. IL-2 receptor beta-chain signaling controls immunosuppressive CD4+ T cells in the draining lymph nodes and lung during allergic airway inflammation in vivo. J Immunol. 2008 Aug 01; 181(3):1917-26. PMID: 18641329.
    Citations:    
  36. Grenningloh R, Miaw SC, Moisan J, Graves BJ, Ho IC. Role of Ets-1 phosphorylation in the effector function of Th cells. Eur J Immunol. 2008 Jun; 38(6):1700-5. PMID: 18465773.
    Citations: 9     Fields:    Translation:AnimalsCells
  37. Kouros-Mehr H, Bechis SK, Slorach EM, Littlepage LE, Egeblad M, Ewald AJ, Pai SY, Ho IC, Werb Z. GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model. Cancer Cell. 2008 Feb; 13(2):141-52. PMID: 18242514.
    Citations: 183     Fields:    Translation:AnimalsCells
  38. Pai SY, Kang BY, Sabadini AM, Parisini E, Truitt ML, Ho IC. Distinct structural requirements of GATA-3 for the regulation of thymocyte and Th2 cell differentiation. J Immunol. 2008 Jan 15; 180(2):1050-9. PMID: 18178845.
    Citations: 7     Fields:    Translation:AnimalsCells
  39. Moisan J, Grenningloh R, Bettelli E, Oukka M, Ho IC. Ets-1 is a negative regulator of Th17 differentiation. J Exp Med. 2007 Nov 26; 204(12):2825-35. PMID: 17967903.
    Citations: 86     Fields:    Translation:AnimalsCells
  40. Peng S, Lalani S, Leavenworth JW, Ho IC, Pauza ME. c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cells. Eur J Immunol. 2007 Oct; 37(10):2868-80. PMID: 17823980.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  41. Ho IC, Pai SY. GATA-3 - not just for Th2 cells anymore. Cell Mol Immunol. 2007 Feb; 4(1):15-29. PMID: 17349208.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  42. Ho IC, Neuzil P, Mraz T, Beldova Z, Gross D, Formanek P, Taborsky M, Niederle P, Ruskin JN, Reddy VY. Use of intracardiac echocardiography to guide implantation of a left atrial appendage occlusion device (PLAATO). Heart Rhythm. 2007 May; 4(5):567-71. PMID: 17467621.
    Citations: 15     Fields:    Translation:Humans
  43. de Guzman Strong C, Wertz PW, Wang C, Yang F, Meltzer PS, Andl T, Millar SE, Ho IC, Pai SY, Segre JA. Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3. J Cell Biol. 2006 Nov 20; 175(4):661-70. PMID: 17116754.
    Citations: 37     Fields:    Translation:AnimalsCells
  44. Kim PJ, Pai SY, Brigl M, Besra GS, Gumperz J, Ho IC. GATA-3 regulates the development and function of invariant NKT cells. J Immunol. 2006 Nov 15; 177(10):6650-9. PMID: 17082577.
    Citations: 59     Fields:    Translation:AnimalsCells
  45. Grenningloh R, Gho A, di Lucia P, Klaus M, Bollag W, Ho IC, Sinigaglia F, Panina-Bordignon P. Cutting Edge: Inhibition of the retinoid X receptor (RXR) blocks T helper 2 differentiation and prevents allergic lung inflammation. J Immunol. 2006 May 01; 176(9):5161-6. PMID: 16621979.
    Citations: 16     Fields:    Translation:AnimalsCells
  46. Kim DC, Hsu FI, Barrett NA, Friend DS, Grenningloh R, Ho IC, Al-Garawi A, Lora JM, Lam BK, Austen KF, Kanaoka Y. Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation. J Immunol. 2006 Apr 01; 176(7):4440-8. PMID: 16547282.
    Citations: 53     Fields:    Translation:AnimalsCells
  47. Zhan Y, Brown C, Maynard E, Anshelevich A, Ni W, Ho IC, Oettgen P. Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodeling. J Clin Invest. 2005 Sep; 115(9):2508-16. PMID: 16138193.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  48. Grenningloh R, Kang BY, Ho IC. Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses. J Exp Med. 2005 Feb 21; 201(4):615-26. PMID: 15728239.
    Citations: 54     Fields:    Translation:AnimalsCells
  49. Kang BY, Miaw SC, Ho IC. ROG negatively regulates T-cell activation but is dispensable for Th-cell differentiation. Mol Cell Biol. 2005 Jan; 25(2):554-62. PMID: 15632058.
    Citations: 17     Fields:    Translation:AnimalsCells
  50. Hausding M, Ho IC, Lehr HA, Weigmann B, Lux C, Schipp M, Galle PR, Finotto S. A stage-specific functional role of the leucine zipper transcription factor c-Maf in lung Th2 cell differentiation. Eur J Immunol. 2004 Dec; 34(12):3401-12. PMID: 15495158.
    Citations: 2     Fields:    Translation:AnimalsCells
  51. Weigmann B, Nemetz A, Becker C, Schmidt J, Strand D, Lehr HA, Galle PR, Ho IC, Neurath MF. A critical regulatory role of leucin zipper transcription factor c-Maf in Th1-mediated experimental colitis. J Immunol. 2004 Sep 01; 173(5):3446-55. PMID: 15322210.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  52. Pai SY, Truitt ML, Ho IC. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):1993-8. PMID: 14769923.
    Citations: 122     Fields:    Translation:AnimalsCells
  53. Miaw SC, Kang BY, White IA, Ho IC. A repressor of GATA-mediated negative feedback mechanism of T cell activation. J Immunol. 2004 Jan 01; 172(1):170-7. PMID: 14688323.
    Citations: 9     Fields:    Translation:AnimalsCells
  54. Pai SY, Truitt ML, Ting CN, Leiden JM, Glimcher LH, Ho IC. Critical roles for transcription factor GATA-3 in thymocyte development. Immunity. 2003 Dec; 19(6):863-75. PMID: 14670303.
    Citations: 130     Fields:    Translation:AnimalsCells
  55. Nurieva RI, Duong J, Kishikawa H, Dianzani U, Rojo JM, Ho Ic, Flavell RA, Dong C. Transcriptional regulation of th2 differentiation by inducible costimulator. Immunity. 2003 Jun; 18(6):801-11. PMID: 12818161.
    Citations: 59     Fields:    Translation:AnimalsCells
  56. Cao S, Liu J, Chesi M, Bergsagel PL, Ho IC, Donnelly RP, Ma X. Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma. J Immunol. 2002 Nov 15; 169(10):5715-25. PMID: 12421951.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  57. Hwang ES, White IA, Ho IC. An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):13026-30. PMID: 12271139.
    Citations: 22     Fields:    Translation:AnimalsCells
  58. Pai SY, Ho IC. c-Rel delivers a one-two punch in Th1 cell differentiation. J Clin Invest. 2002 Sep; 110(6):741-2. PMID: 12235102.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  59. Hwang ES, Ho IC. Regulation of thymocyte homeostasis by Fliz1. Immunology. 2002 Aug; 106(4):464-9. PMID: 12153508.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  60. Hwang ES, Choi A, Ho IC. Transcriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1. J Immunol. 2002 Jul 01; 169(1):248-53. PMID: 12077251.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  61. Ho IC, Glimcher LH. Transcription: tantalizing times for T cells. Cell. 2002 Apr; 109 Suppl:S109-20. PMID: 11983157.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  62. Kishikawa H, Sun J, Choi A, Miaw SC, Ho IC. The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3. J Immunol. 2001 Oct 15; 167(8):4414-20. PMID: 11591766.
    Citations: 47     Fields:    Translation:AnimalsCells
  63. Ho IC, Arm JP, Bingham CO, Choi A, Austen KF, Glimcher LH. A novel group of phospholipase A2s preferentially expressed in type 2 helper T cells. J Biol Chem. 2001 May 25; 276(21):18321-6. PMID: 11278438.
    Citations: 15     Fields:    Translation:AnimalsCells
  64. Pauza ME, Nguyen A, Wolfe T, Ho IC, Glimcher LH, von Herrath M, Lo D. Variable effects of transgenic c-Maf on autoimmune diabetes. Diabetes. 2001 Jan; 50(1):39-46. PMID: 11147792.
    Citations: 8     Fields:    Translation:AnimalsCells
  65. Miaw SC, Choi A, Yu E, Kishikawa H, Ho IC. ROG, repressor of GATA, regulates the expression of cytokine genes. Immunity. 2000 Mar; 12(3):323-33. PMID: 10755619.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  66. Kim JI, Ho IC, Grusby MJ, Glimcher LH. The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. Immunity. 1999 Jun; 10(6):745-51. PMID: 10403649.
    Citations: 129     Fields:    Translation:AnimalsCells
  67. Kim JI, Li T, Ho IC, Grusby MJ, Glimcher LH. Requirement for the c-Maf transcription factor in crystallin gene regulation and lens development. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3781-5. PMID: 10097114.
    Citations: 73     Fields:    Translation:AnimalsCells
  68. Ho IC, Kaplan MH, Jackson-Grusby L, Glimcher LH, Grusby MJ. Marking IL-4-producing cells by knock-in of the IL-4 gene. Int Immunol. 1999 Feb; 11(2):243-7. PMID: 10069422.
    Citations: 2     Fields:    Translation:AnimalsCells
  69. Ho IC, Kim JI, Szabo SJ, Glimcher LH. Tissue-specific regulation of cytokine gene expression. Cold Spring Harb Symp Quant Biol. 1999; 64:573-84. PMID: 11232334.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  70. Ho IC, Kim JH, Rooney JW, Spiegelman BM, Glimcher LH. A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis. Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26):15537-41. PMID: 9861004.
    Citations: 25     Fields:    Translation:AnimalsCells
  71. Ho IC, Lo D, Glimcher LH. c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms. J Exp Med. 1998 Nov 16; 188(10):1859-66. PMID: 9815263.
    Citations: 89     Fields:    Translation:AnimalsCells
  72. Oukka M, Ho IC, de la Brousse FC, Hoey T, Grusby MJ, Glimcher LH. The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity. 1998 Sep; 9(3):295-304. PMID: 9768749.
    Citations: 83     Fields:    Translation:AnimalsCells
  73. Szabo SJ, Glimcher LH, Ho IC. Genes that regulate interleukin-4 expression in T cells. Curr Opin Immunol. 1997 Dec; 9(6):776-81. PMID: 9492977.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  74. Ho IC, Hodge MR, Rooney JW, Glimcher LH. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell. 1996 Jun 28; 85(7):973-83. PMID: 8674125.
    Citations: 175     Fields:    Translation:AnimalsCells
  75. Wang CY, Petryniak B, Ho IC, Thompson CB, Leiden JM. Evolutionarily conserved Ets family members display distinct DNA binding specificities. J Exp Med. 1992 May 01; 175(5):1391-9. PMID: 1569404.
    Citations: 70     Fields:    Translation:HumansCells
  76. Thompson CB, Wang CY, Ho IC, Bohjanen PR, Petryniak B, June CH, Miesfeldt S, Zhang L, Nabel GJ, Karpinski B, et al. cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1. Mol Cell Biol. 1992 Mar; 12(3):1043-53. PMID: 1545787.
    Citations: 87     Fields:    Translation:HumansCells
  77. Ho IC, Vorhees P, Marin N, Oakley BK, Tsai SF, Orkin SH, Leiden JM. Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene. EMBO J. 1991 May; 10(5):1187-92. PMID: 1827068.
    Citations: 114     Fields:    Translation:HumansCells
  78. Ho IC, Bhat NK, Gottschalk LR, Lindsten T, Thompson CB, Papas TS, Leiden JM. Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancer. Science. 1990 Nov 09; 250(4982):814-8. PMID: 2237431.
    Citations: 78     Fields:    Translation:HumansCells
  79. Ho IC, Leiden JM. The T alpha 2 nuclear protein binding site from the human T cell receptor alpha enhancer functions as both a T cell-specific transcriptional activator and repressor. J Exp Med. 1990 Nov 01; 172(5):1443-9. PMID: 2230652.
    Citations: 7     Fields:    Translation:HumansCells
  80. Ho IC, Leiden JM. Regulation of the human T-cell receptor alpha gene enhancer: multiple ubiquitous and T-cell-specific nuclear proteins interact with four hypomethylated enhancer elements. Mol Cell Biol. 1990 Sep; 10(9):4720-7. PMID: 2388624.
    Citations: 23     Fields:    Translation:HumansCells
  81. Ho IC, Yang LH, Morle G, Leiden JM. A T-cell-specific transcriptional enhancer element 3' of C alpha in the human T-cell receptor alpha locus. Proc Natl Acad Sci U S A. 1989 Sep; 86(17):6714-8. PMID: 2788889.
    Citations: 63     Fields:    Translation:HumansCells
  82. Tsai IK, Yen MY, Ho IC, Yu KW, Liu CY, Cheng DL. Clostridium perfringens septicemia with massive hemolysis. Scand J Infect Dis. 1989; 21(4):467-71. PMID: 2555910.
    Citations: 4     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.