Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Richard Malley, M.D.

Title
Institution
Department
Address
Phone
Fax

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI135720 (MALLEY, RICHARD) Dec 15, 2017 - Nov 30, 2022
    NIH/NIAID
    Optimization and preclinical development of a TB Multiple Antigen Presenting System (MAPS) vaccine
    Role: Principal Investigator
  2. R56AI104975 (MALLEY, RICHARD) Aug 1, 2014 - Jul 31, 2015
    NIH/NIAID
    S. pneumoniae pilus regulation and host response
    Role: Principal Investigator
  3. R01AI100114 (MALLEY, RICHARD) Apr 1, 2012 - Mar 31, 2017
    NIH/NIAID
    Enhancing neonatal immunity to Streptococcus pneumoniae
    Role: Principal Investigator
  4. R01AI066013 (MALLEY, RICHARD) Mar 1, 2007 - Feb 28, 2012
    NIH/NIAID
    Mechanisms of Immunity to Pneumococcal Colonization
    Role: Principal Investigator
  5. R01AI067737 (MALLEY, RICHARD) Jan 15, 2005 - Dec 31, 2011
    NIH/NIAID
    Pneumococcal immunization through a novel mechanism
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Keech CA, Morrison R, Anderson P, Tate A, Flores J, Goldblatt D, Briles D, Hural J, Malley R, Alderson MR. A Phase 1 Randomized, Placebo-controlled, Observer-blinded Trial to Evaluate the Safety and Immunogenicity of Inactivated Streptococcus pneumoniae Whole-cell Vaccine in Adults. Pediatr Infect Dis J. 2020 Apr; 39(4):345-351. PMID: 31895881.
    Citations:    
  2. Campos IB, Cardoso CP, Fratelli F, Herd M, Moffitt KL, Lu YJ, Malley R, Leite LCC, Gonçalves VM. Process intensification for production of Streptococcus pneumoniae whole-cell vaccine. Biotechnol Bioeng. 2020 Feb 18. PMID: 32068248.
    Citations:    
  3. O'Hara JM, Redhu NS, Cheung E, Robertson NG, Patik I, Sayed SE, Thompson CM, Herd M, Lucas KB, Conaway E, Morton CC, Farber DL, Malley R, Horwitz BH. Generation of protective pneumococcal-specific nasal resident memory CD4+ T cells via parenteral immunization. Mucosal Immunol. 2020 Jan; 13(1):172-182. PMID: 31659300.
    Citations:    
  4. Manning J, Dunne EM, Wang N, Pedersen JS, Ogier JM, Burt RA, Mulholland EK, Robins-Browne RM, Malley R, Wijburg OL, Satzke C. Effect of a pneumococcal whole cell vaccine on influenza A-induced pneumococcal otitis media in infant mice. Vaccine. 2019 Jun 06; 37(26):3495-3504. PMID: 31103366.
    Citations:    
  5. Campo JJ, Le TQ, Pablo JV, Hung C, Teng AA, Tettelin H, Tate A, Hanage WP, Alderson MR, Liang X, Malley R, Lipsitch M, Croucher NJ. Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination. Elife. 2018 12 28; 7. PMID: 30592459.
    Citations:    Fields:    
  6. Malley R. Introduction of New Journal Section-Translational Medicine. Pediatr Infect Dis J. 2018 11; 37(11):1175. PMID: 30153234.
    Citations:    Fields:    
  7. Oliver E, Pope C, Clarke E, Langton Hewer C, Ogunniyi AD, Paton JC, Mitchell T, Malley R, Finn A. Th17 responses to pneumococcus in blood and adenoidal cells in children. Clin Exp Immunol. 2019 02; 195(2):213-225. PMID: 30325010.
    Citations: 1     Fields:    
  8. Lu YJ, Oliver E, Zhang F, Pope C, Finn A, Malley R. Screening for Th17-Dependent Pneumococcal Vaccine Antigens: Comparison of Murine and Human Cellular Immune Responses. Infect Immun. 2018 11; 86(11). PMID: 30150255.
    Citations:    Fields:    
  9. Zhang F, Ledue O, Jun M, Goulart C, Malley R, Lu YJ. Protection against Staphylococcus aureus Colonization and Infection by B- and T-Cell-Mediated Mechanisms. mBio. 2018 10 16; 9(5). PMID: 30327437.
    Citations:    Fields:    
  10. Moffitt K, Cheung E, Manis J, Malley R. Evaluation of the Role of stat3 in Antibody and TH17-Mediated Responses to Pneumococcal Immunization and Infection by Use of a Mouse Model of Autosomal Dominant Hyper-IgE Syndrome. Infect Immun. 2018 05; 86(5). PMID: 29463618.
    Citations:    Fields:    Translation:AnimalsCells
  11. Jochems SP, Weiser JN, Malley R, Ferreira DM. The immunological mechanisms that control pneumococcal carriage. PLoS Pathog. 2017 12; 13(12):e1006665. PMID: 29267378.
    Citations: 3     Fields:    Translation:Humans
  12. Goulart C, Rodriguez D, Kanno AI, Converso TR, Lu YJ, Malley R, Leite LCC. A Combination of Recombinant Mycobacterium bovis BCG Strains Expressing Pneumococcal Proteins Induces Cellular and Humoral Immune Responses and Protects against Pneumococcal Colonization and Sepsis. Clin Vaccine Immunol. 2017 Oct; 24(10). PMID: 28768668.
    Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
  13. Basset A, Herd M, Daly R, Dove SL, Malley R. The Pneumococcal Type 1 Pilus Genes Are Thermoregulated and Are Repressed by a Member of the Snf2 Protein Family. J Bacteriol. 2017 08 01; 199(15). PMID: 28507246.
    Citations:    Fields:    Translation:Cells
  14. Zhang F, Jun M, Ledue O, Herd M, Malley R, Lu YJ. Antibody-mediated protection against Staphylococcus aureus dermonecrosis and sepsis by a whole cell vaccine. Vaccine. 2017 07 05; 35(31):3834-3843. PMID: 28601365.
    Citations:    Fields:    Translation:AnimalsCells
  15. Goulart C, Rodriguez D, Kanno AI, Lu YJ, Malley R, Leite LC. Recombinant BCG expressing a PspA-PdT fusion protein protects mice against pneumococcal lethal challenge in a prime-boost strategy. Vaccine. 2017 03 23; 35(13):1683-1691. PMID: 28242071.
    Citations: 2     Fields:    Translation:AnimalsCells
  16. Campos IB, Herd M, Moffitt KL, Lu YJ, Darrieux M, Malley R, Leite LC, Gonçalves VM. IL-17A and complement contribute to killing of pneumococci following immunization with a pneumococcal whole cell vaccine. Vaccine. 2017 03 01; 35(9):1306-1315. PMID: 28161422.
    Citations: 2     Fields:    Translation:AnimalsCells
  17. Jabara HH, Lee JJ, Janssen E, Ullas S, Liadaki K, Garibyan L, Benson H, Sannikova T, Bram R, Hammarstrom L, Cruz AC, Siegel R, Manis J, Malley R, Geha RS. Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice. J Allergy Clin Immunol. 2017 Apr; 139(4):1293-1301.e4. PMID: 27609654.
    Citations:    Fields:    Translation:HumansAnimalsCells
  18. Moffitt K, Malley R. Rationale and prospects for novel pneumococcal vaccines. Hum Vaccin Immunother. 2016; 12(2):383-92. PMID: 26535755.
    Citations: 6     Fields:    Translation:HumansCellsPHPublic Health
  19. Choi EH, Zhang F, Lu YJ, Malley R. Capsular Polysaccharide (CPS) Release by Serotype 3 Pneumococcal Strains Reduces the Protective Effect of Anti-Type 3 CPS Antibodies. Clin Vaccine Immunol. 2016 02; 23(2):162-7. PMID: 26677201.
    Citations: 5     Fields:    Translation:AnimalsCells
  20. Trzcinski K, Li Y, Weinberger DM, Thompson CM, Cordy D, Bessolo A, Malley R, Lipsitch M. Effect of Serotype on Pneumococcal Competition in a Mouse Colonization Model. mBio. 2015 Sep 15; 6(5):e00902-15. PMID: 26374118.
    Citations: 12     Fields:    Translation:AnimalsCells
  21. Moffitt K, Howard A, Martin S, Cheung E, Herd M, Basset A, Malley R. T(H)17-Mediated Protection against Pneumococcal Carriage by a Whole-Cell Vaccine Is Dependent on Toll-Like Receptor 2 and Surface Lipoproteins. Clin Vaccine Immunol. 2015 Aug; 22(8):909-16. PMID: 26041040.
    Citations: 3     Fields:    Translation:AnimalsCells
  22. Hua CZ, Howard A, Malley R, Lu YJ. Effect of nonheme iron-containing ferritin Dpr in the stress response and virulence of pneumococci. Infect Immun. 2014 Sep; 82(9):3939-47. PMID: 25001605.
    Citations: 4     Fields:    Translation:AnimalsCells
  23. van Sorge NM, Cole JN, Kuipers K, Henningham A, Aziz RK, Kasirer-Friede A, Lin L, Berends ETM, Davies MR, Dougan G, Zhang F, Dahesh S, Shaw L, Gin J, Cunningham M, Merriman JA, Hütter J, Lepenies B, Rooijakkers SHM, Malley R, Walker MJ, Shattil SJ, Schlievert PM, Choudhury B, Nizet V. The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design. Cell Host Microbe. 2014 Jun 11; 15(6):729-740. PMID: 24922575.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  24. Moffitt K, Skoberne M, Howard A, Gavrilescu LC, Gierahn T, Munzer S, Dixit B, Giannasca P, Flechtner JB, Malley R. Toll-like receptor 2-dependent protection against pneumococcal carriage by immunization with lipidated pneumococcal proteins. Infect Immun. 2014 May; 82(5):2079-86. PMID: 24614661.
    Citations: 8     Fields:    Translation:AnimalsCells
  25. Gonçalves VM, Dias WO, Campos IB, Liberman C, Sbrogio-Almeida ME, Silva EP, Cardoso CP, Alderson M, Robertson G, Maisonneuve JF, Tate A, Anderson P, Malley R, Fratelli F, Leite LC. Development of a whole cell pneumococcal vaccine: BPL inactivation, cGMP production, and stability. Vaccine. 2014 Feb 19; 32(9):1113-20. PMID: 24342254.
    Citations: 5     Fields:    Translation:AnimalsCells
  26. Finn A, Malley R. Immunisation against meningococcus B. Lancet. 2013 Sep 07; 382(9895):857. PMID: 24012268.
    Citations:    Fields:    Translation:HumansCells
  27. Zhang F, Lu YJ, Malley R. Multiple antigen-presenting system (MAPS) to induce comprehensive B- and T-cell immunity. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13564-9. PMID: 23898212.
    Citations: 10     Fields:    Translation:HumansCells
  28. Basset A, Zhang F, Benes C, Sayeed S, Herd M, Thompson C, Golenbock DT, Camilli A, Malley R. Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein. J Biol Chem. 2013 Jan 25; 288(4):2665-75. PMID: 23233677.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  29. Li Y, Gierahn T, Thompson CM, Trzcinski K, Ford CB, Croucher N, Gouveia P, Flechtner JB, Malley R, Lipsitch M. Distinct effects on diversifying selection by two mechanisms of immunity against Streptococcus pneumoniae. PLoS Pathog. 2012; 8(11):e1002989. PMID: 23144610.
    Citations: 19     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  30. Moffitt KL, Malley R, Lu YJ. Identification of protective pneumococcal T(H)17 antigens from the soluble fraction of a killed whole cell vaccine. PLoS One. 2012; 7(8):e43445. PMID: 22905267.
    Citations: 12     Fields:    Translation:AnimalsCellsPHPublic Health
  31. Nigrovic LE, Malley R, Kuppermann N. Meta-analysis of bacterial meningitis score validation studies. Arch Dis Child. 2012 Sep; 97(9):799-805. PMID: 22764093.
    Citations: 9     Fields:    Translation:Humans
  32. Moffitt KL, Yadav P, Weinberger DM, Anderson PW, Malley R. Broad antibody and T cell reactivity induced by a pneumococcal whole-cell vaccine. Vaccine. 2012 Jun 19; 30(29):4316-22. PMID: 22682288.
    Citations: 12     Fields:    Translation:AnimalsCells
  33. Regev-Yochay G, Abullaish I, Malley R, Shainberg B, Varon M, Roytman Y, Ziv A, Goral A, Elhamdany A, Rahav G, Raz M. Streptococcus pneumoniae carriage in the Gaza strip. PLoS One. 2012; 7(4):e35061. PMID: 22539955.
    Citations: 7     Fields:    Translation:HumansCells
  34. Lundgren A, Bhuiyan TR, Novak D, Kaim J, Reske A, Lu YJ, Qadri F, Malley R. Characterization of Th17 responses to Streptococcus pneumoniae in humans: comparisons between adults and children in a developed and a developing country. Vaccine. 2012 Jun 06; 30(26):3897-907. PMID: 22504663.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  35. Lu YJ, Zhang F, Sayeed S, Thompson CM, Szu S, Anderson PW, Malley R. A bivalent vaccine to protect against Streptococcus pneumoniae and Salmonella typhi. Vaccine. 2012 May 14; 30(23):3405-12. PMID: 22465750.
    Citations: 5     Fields:    Translation:AnimalsCells
  36. Malley R, Anderson PW. Serotype-independent pneumococcal experimental vaccines that induce cellular as well as humoral immunity. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3623-7. PMID: 22308483.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  37. Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22; 119(12):2819-28. PMID: 22302739.
    Citations: 45     Fields:    Translation:AnimalsCells
  38. Basset A, Turner KH, Boush E, Sayeed S, Dove SL, Malley R. An epigenetic switch mediates bistable expression of the type 1 pilus genes in Streptococcus pneumoniae. J Bacteriol. 2012 Mar; 194(5):1088-91. PMID: 22194460.
    Citations: 7     Fields:    Translation:Cells
  39. Zhang Q, Leong SC, McNamara PS, Mubarak A, Malley R, Finn A. Characterisation of regulatory T cells in nasal associated lymphoid tissue in children: relationships with pneumococcal colonization. PLoS Pathog. 2011 Aug; 7(8):e1002175. PMID: 21852948.
    Citations: 27     Fields:    Translation:HumansCells
  40. Basset A, Turner KH, Boush E, Sayeed S, Dove SL, Malley R. Expression of the type 1 pneumococcal pilus is bistable and negatively regulated by the structural component RrgA. Infect Immun. 2011 Aug; 79(8):2974-83. PMID: 21576325.
    Citations: 16     Fields:    Translation:HumansCells
  41. Moffitt KL, Malley R. Next generation pneumococcal vaccines. Curr Opin Immunol. 2011 Jun; 23(3):407-13. PMID: 21514128.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  42. Weinberger DM, Malley R, Lipsitch M. Serotype replacement in disease after pneumococcal vaccination. Lancet. 2011 Dec 03; 378(9807):1962-73. PMID: 21492929.
    Citations: 211     Fields:    Translation:HumansCells
  43. Moffitt KL, Gierahn TM, Lu YJ, Gouveia P, Alderson M, Flechtner JB, Higgins DE, Malley R. T(H)17-based vaccine design for prevention of Streptococcus pneumoniae colonization. Cell Host Microbe. 2011 Feb 17; 9(2):158-65. PMID: 21320698.
    Citations: 70     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  44. Nigrovic LE, Malley R, Agrawal D, Kuppermann N. Low risk of bacterial meningitis in children with a positive enteroviral polymerase chain reaction test result. Clin Infect Dis. 2010 Nov 15; 51(10):1221-2. PMID: 20964523.
    Citations: 5     Fields:    Translation:HumansCells
  45. Lu YJ, Leite L, Gonçalves VM, Dias Wde O, Liberman C, Fratelli F, Alderson M, Tate A, Maisonneuve JF, Robertson G, Graca R, Sayeed S, Thompson CM, Anderson P, Malley R. GMP-grade pneumococcal whole-cell vaccine injected subcutaneously protects mice from nasopharyngeal colonization and fatal aspiration-sepsis. Vaccine. 2010 Nov 03; 28(47):7468-75. PMID: 20858450.
    Citations: 27     Fields:    Translation:AnimalsCells
  46. Regev-Yochay G, Hanage WP, Trzcinski K, Rifas-Shiman SL, Lee G, Bessolo A, Huang SS, Pelton SI, McAdam AJ, Finkelstein JA, Lipsitch M, Malley R. Re-emergence of the type 1 pilus among Streptococcus pneumoniae isolates in Massachusetts, USA. Vaccine. 2010 Jul 05; 28(30):4842-6. PMID: 20434550.
    Citations: 23     Fields:    Translation:HumansCells
  47. Lu YJ, Yadav P, Clements JD, Forte S, Srivastava A, Thompson CM, Seid R, Look J, Alderson M, Tate A, Maisonneuve JF, Robertson G, Anderson PW, Malley R. Options for inactivation, adjuvant, and route of topical administration of a killed, unencapsulated pneumococcal whole-cell vaccine. Clin Vaccine Immunol. 2010 Jun; 17(6):1005-12. PMID: 20427625.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  48. Malley R. Antibody and cell-mediated immunity to Streptococcus pneumoniae: implications for vaccine development. J Mol Med (Berl). 2010 Feb; 88(2):135-42. PMID: 20049411.
    Citations: 32     Fields:    Translation:HumansCells
  49. Bogaert D, Thompson CM, Trzcinski K, Malley R, Lipsitch M. The role of complement in innate and adaptive immunity to pneumococcal colonization and sepsis in a murine model. Vaccine. 2010 Jan 08; 28(3):681-5. PMID: 19892042.
    Citations: 13     Fields:    Translation:AnimalsCells
  50. Regev-Yochay G, Raz M, Carmeli Y, Shainberg B, Navon-Venezia S, Pinco E, Leavitt A, Keller N, Rahav G, Malley R, Rubinstein E. Parental Staphylococcus aureus carriage is associated with staphylococcal carriage in young children. Pediatr Infect Dis J. 2009 Nov; 28(11):960-5. PMID: 19738508.
    Citations: 12     Fields:    Translation:HumansCells
  51. Lu YJ, Skovsted IC, Thompson CM, Anderson PW, Malley R. Mechanisms in the serotype-independent pneumococcal immunity induced in mice by intranasal vaccination with the cell wall polysaccharide. Microb Pathog. 2009 Sep; 47(3):177-82. PMID: 19577628.
    Citations: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  52. Weinberger DM, Trzcinski K, Lu YJ, Bogaert D, Brandes A, Galagan J, Anderson PW, Malley R, Lipsitch M. Pneumococcal capsular polysaccharide structure predicts serotype prevalence. PLoS Pathog. 2009 Jun; 5(6):e1000476. PMID: 19521509.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  53. Kanegaye JT, Nigrovic LE, Malley R, Cannavino CR, Schwab SH, Bennett JE, Mohseni MM, Wang VJ, Katsogridakis YL, Herman MI, Kuppermann N. Diagnostic value of immature neutrophils (bands) in the cerebrospinal fluid of children with cerebrospinal fluid pleocytosis. Pediatrics. 2009 Jun; 123(6):e967-71. PMID: 19451189.
    Citations:    Fields:    Translation:HumansCells
  54. Regev-Yochay G, Lipsitch M, Basset A, Rubinstein E, Dagan R, Raz M, Malley R. The pneumococcal pilus predicts the absence of Staphylococcus aureus co-colonization in pneumococcal carriers. Clin Infect Dis. 2009 Mar 15; 48(6):760-3. PMID: 19207082.
    Citations: 23     Fields:    Translation:HumansCells
  55. Lu YJ, Forte S, Thompson CM, Anderson PW, Malley R. Protection against Pneumococcal colonization and fatal pneumonia by a trivalent conjugate of a fusion protein with the cell wall polysaccharide. Infect Immun. 2009 May; 77(5):2076-83. PMID: 19255193.
    Citations: 27     Fields:    Translation:AnimalsCells
  56. Myers WP, Myers AP, Cox-Singh J, Lau HC, Mokuai B, Malley R. Micro-geographic risk factors for malarial infection. Malar J. 2009 Feb 13; 8:27. PMID: 19216781.
    Citations: 9     Fields:    Translation:HumansAnimalsPHPublic Health
  57. Nigrovic LE, Malley R, Kuppermann N. Cerebrospinal fluid pleocytosis in children in the era of bacterial conjugate vaccines: distinguishing the child with bacterial and aseptic meningitis. Pediatr Emerg Care. 2009 Feb; 25(2):112-7; quiz 118-20. PMID: 19225382.
    Citations: 1     Fields:    Translation:Humans
  58. Bogaert D, Weinberger D, Thompson C, Lipsitch M, Malley R. Impaired innate and adaptive immunity to Streptococcus pneumoniae and its effect on colonization in an infant mouse model. Infect Immun. 2009 Apr; 77(4):1613-22. PMID: 19168741.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  59. Malley RC, Muller HK, Norval M, Woods GM. Vitamin D3 deficiency enhances contact hypersensitivity in male but not in female mice. Cell Immunol. 2009; 255(1-2):33-40. PMID: 19012883.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  60. Nigrovic LE, Malley R, Macias CG, Kanegaye JT, Moro-Sutherland DM, Schremmer RD, Schwab SH, Agrawal D, Mansour KM, Bennett JE, Katsogridakis YL, Mohseni MM, Bulloch B, Steele DW, Kaplan RL, Herman MI, Bandyopadhyay S, Dayan P, Truong UT, Wang VJ, Bonsu BK, Chapman JL, Kuppermann N. Effect of antibiotic pretreatment on cerebrospinal fluid profiles of children with bacterial meningitis. Pediatrics. 2008 Oct; 122(4):726-30. PMID: 18829794.
    Citations: 25     Fields:    Translation:HumansCells
  61. Lu YJ, Gross J, Bogaert D, Finn A, Bagrade L, Zhang Q, Kolls JK, Srivastava A, Lundgren A, Forte S, Thompson CM, Harney KF, Anderson PW, Lipsitch M, Malley R. Interleukin-17A mediates acquired immunity to pneumococcal colonization. PLoS Pathog. 2008 Sep 19; 4(9):e1000159. PMID: 18802458.
    Citations: 184     Fields:    Translation:HumansAnimalsCells
  62. Regev-Yochay G, Bogaert D, Malley R, Hermans PW, Veenhoven RH, Sanders EA, Lipsitch M, Rubinstein E. Does pneumococcal conjugate vaccine influence Staphylococcus aureus carriage in children? Clin Infect Dis. 2008 Jul 15; 47(2):289-91; author reply 291-2. PMID: 18564933.
    Citations: 8     Fields:    Translation:HumansCells
  63. Nigrovic LE, Kuppermann N, Malley R. Children with bacterial meningitis presenting to the emergency department during the pneumococcal conjugate vaccine era. Acad Emerg Med. 2008 Jun; 15(6):522-8. PMID: 18616437.
    Citations: 14     Fields:    Translation:HumansCells
  64. Weinberger DM, Dagan R, Givon-Lavi N, Regev-Yochay G, Malley R, Lipsitch M. Epidemiologic evidence for serotype-specific acquired immunity to pneumococcal carriage. J Infect Dis. 2008 Jun 01; 197(11):1511-8. PMID: 18471062.
    Citations: 45     Fields:    Translation:HumansCells
  65. Trzcinski K, Thompson CM, Srivastava A, Basset A, Malley R, Lipsitch M. Protection against nasopharyngeal colonization by Streptococcus pneumoniae is mediated by antigen-specific CD4+ T cells. Infect Immun. 2008 Jun; 76(6):2678-84. PMID: 18391006.
    Citations: 36     Fields:    Translation:AnimalsCells
  66. Regev-Yochay G, Malley R, Rubinstein E, Raz M, Dagan R, Lipsitch M. In vitro bactericidal activity of Streptococcus pneumoniae and bactericidal susceptibility of Staphylococcus aureus strains isolated from cocolonized versus noncocolonized children. J Clin Microbiol. 2008 Feb; 46(2):747-9. PMID: 18039795.
    Citations: 10     Fields:    Translation:HumansCells
  67. Basset A, Thompson CM, Hollingshead SK, Briles DE, Ades EW, Lipsitch M, Malley R. Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins. Infect Immun. 2007 Nov; 75(11):5460-4. PMID: 17698570.
    Citations: 36     Fields:    Translation:AnimalsCellsPHPublic Health
  68. Malley R, Lipsitch M, Bogaert D, Thompson CM, Hermans P, Watkins AC, Sethi S, Murphy TF. Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease. J Infect Dis. 2007 Sep 15; 196(6):928-35. PMID: 17703425.
    Citations: 16     Fields:    Translation:HumansCells
  69. Regev-Yochay G, Trzcinski K, Thompson CM, Lipsitch M, Malley R. SpxB is a suicide gene of Streptococcus pneumoniae and confers a selective advantage in an in vivo competitive colonization model. J Bacteriol. 2007 Sep; 189(18):6532-9. PMID: 17631628.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  70. Basset A, Trzcinski K, Hermos C, O'Brien KL, Reid R, Santosham M, McAdam AJ, Lipsitch M, Malley R. Association of the pneumococcal pilus with certain capsular serotypes but not with increased virulence. J Clin Microbiol. 2007 Jun; 45(6):1684-9. PMID: 17392439.
    Citations: 35     Fields:    Translation:HumansCellsPHPublic Health
  71. Ha U, Lim JH, Jono H, Koga T, Srivastava A, Malley R, Pagès G, Pouysségur J, Li JD. A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae. J Immunol. 2007 Feb 01; 178(3):1736-47. PMID: 17237423.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  72. Nigrovic LE, Kuppermann N, Macias CG, Cannavino CR, Moro-Sutherland DM, Schremmer RD, Schwab SH, Agrawal D, Mansour KM, Bennett JE, Katsogridakis YL, Mohseni MM, Bulloch B, Steele DW, Kaplan RL, Herman MI, Bandyopadhyay S, Dayan P, Truong UT, Wang VJ, Bonsu BK, Chapman JL, Kanegaye JT, Malley R. Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis. JAMA. 2007 Jan 03; 297(1):52-60. PMID: 17200475.
    Citations: 36     Fields:    Translation:Humans
  73. Srivastava A, Casey H, Johnson N, Levy O, Malley R. Recombinant bactericidal/permeability-increasing protein rBPI21 protects against pneumococcal disease. Infect Immun. 2007 Jan; 75(1):342-9. PMID: 17101667.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  74. Regev-Yochay G, Trzcinski K, Thompson CM, Malley R, Lipsitch M. Interference between Streptococcus pneumoniae and Staphylococcus aureus: In vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae. J Bacteriol. 2006 Jul; 188(13):4996-5001. PMID: 16788209.
    Citations: 62     Fields:    Translation:Cells
  75. Malley R, Srivastava A, Lipsitch M, Thompson CM, Watkins C, Tzianabos A, Anderson PW. Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide. Infect Immun. 2006 Apr; 74(4):2187-95. PMID: 16552049.
    Citations: 74     Fields:    Translation:AnimalsCells
  76. Kenzel S, Mancuso G, Malley R, Teti G, Golenbock DT, Henneke P. c-Jun kinase is a critical signaling molecule in a neonatal model of group B streptococcal sepsis. J Immunol. 2006 Mar 01; 176(5):3181-8. PMID: 16493078.
    Citations: 15     Fields:    Translation:AnimalsCells
  77. Srivastava A, Henneke P, Visintin A, Morse SC, Martin V, Watkins C, Paton JC, Wessels MR, Golenbock DT, Malley R. The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease. Infect Immun. 2005 Oct; 73(10):6479-87. PMID: 16177320.
    Citations: 63     Fields:    Translation:AnimalsCells
  78. Trzcinski K, Thompson C, Malley R, Lipsitch M. Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model. Infect Immun. 2005 Oct; 73(10):7043-6. PMID: 16177389.
    Citations: 28     Fields:    Translation:AnimalsCells
  79. Malley R, Trzcinski K, Srivastava A, Thompson CM, Anderson PW, Lipsitch M. CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization. Proc Natl Acad Sci U S A. 2005 Mar 29; 102(13):4848-53. PMID: 15781870.
    Citations: 140     Fields:    Translation:AnimalsCells
  80. Lipsitch M, Whitney CG, Zell E, Kaijalainen T, Dagan R, Malley R. Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease? PLoS Med. 2005 Jan; 2(1):e15. PMID: 15696204.
    Citations: 46     Fields:    Translation:Humans
  81. Nigrovic LE, Kuppermann N, McAdam AJ, Malley R. Cerebrospinal latex agglutination fails to contribute to the microbiologic diagnosis of pretreated children with meningitis. Pediatr Infect Dis J. 2004 Aug; 23(8):786-8. PMID: 15295235.
    Citations: 6     Fields:    Translation:Humans
  82. Malley R, Morse SC, Leite LC, Areas AP, Ho PL, Kubrusly FS, Almeida IC, Anderson P. Multiserotype protection of mice against pneumococcal colonization of the nasopharynx and middle ear by killed nonencapsulated cells given intranasally with a nontoxic adjuvant. Infect Immun. 2004 Jul; 72(7):4290-2. PMID: 15213177.
    Citations: 19     Fields:    Translation:AnimalsCells
  83. Malley R, Stack AM, Husson RN, Thompson CM, Fleisher GR, Saladino RA. Development of a model of focal pneumococcal pneumonia in young rats. J Immune Based Ther Vaccines. 2004 Jan 23; 2(1):2. PMID: 14741053.
    Citations: 2     
  84. Malley R, Henneke P, Morse SC, Cieslewicz MJ, Lipsitch M, Thompson CM, Kurt-Jones E, Paton JC, Wessels MR, Golenbock DT. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1966-71. PMID: 12569171.
    Citations: 202     Fields:    Translation:AnimalsCells
  85. Kuppermann N, Malley R, Huskins WC. A new prognostic scoring system for meningococcal septic shock in children: comparison with three other scoring systems. Intensive Care Med. 2003 Feb; 29(2):333; author reply 334. PMID: 12594597.
    Citations: 1     Fields:    Translation:Humans
  86. Marcin JP, Glaser N, Barnett P, McCaslin I, Nelson D, Trainor J, Louie J, Kaufman F, Quayle K, Roback M, Malley R, Kuppermann N. Factors associated with adverse outcomes in children with diabetic ketoacidosis-related cerebral edema. J Pediatr. 2002 Dec; 141(6):793-7. PMID: 12461495.
    Citations: 19     Fields:    Translation:Humans
  87. Nigrovic LE, Kuppermann N, Malley R. Development and validation of a multivariable predictive model to distinguish bacterial from aseptic meningitis in children in the post-Haemophilus influenzae era. Pediatrics. 2002 Oct; 110(4):712-9. PMID: 12359784.
    Citations: 28     Fields:    Translation:HumansCells
  88. Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT. Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol. 2002 Oct 01; 169(7):3970-7. PMID: 12244198.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  89. Molrine DC, Antin JH, Guinan EC, Soiffer RJ, MacDonald K, Malley R, Malinoski F, Trocciola S, Wilson M, Ambrosino DM. Donor immunization with pneumococcal conjugate vaccine and early protective antibody responses following allogeneic hematopoietic cell transplantation. Blood. 2003 Feb 01; 101(3):831-6. PMID: 12393732.
    Citations: 17     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
  90. Nguyen T, Malley R, Inkelis S, Kuppermann N. Comparison of prediction models for adverse outcome in pediatric meningococcal disease using artificial neural network and logistic regression analyses. J Clin Epidemiol. 2002 Jul; 55(7):687-95. PMID: 12160917.
    Citations: 7     Fields:    Translation:Humans
  91. Inkelis SH, O'Leary D, Wang VJ, Malley R, Nicholson MK, Kuppermann N. Extremity pain and refusal to walk in children with invasive meningococcal disease. Pediatrics. 2002 Jul; 110(1 Pt 1):e3. PMID: 12093984.
    Citations: 4     Fields:    Translation:HumansCells
  92. Levy O, Bourquin JP, McQueen A, Cantor AB, Lachenauer C, Malley R. Fatal disseminated Candida lusitaniae infection in an infant with chronic granulomatous disease. Pediatr Infect Dis J. 2002 Mar; 21(3):262-4. PMID: 12005097.
    Citations: 2     Fields:    Translation:Humans
  93. Malley R, Lipsitch M, Stack A, Saladino R, Fleisher G, Pelton S, Thompson C, Briles D, Anderson P. Intranasal immunization with killed unencapsulated whole cells prevents colonization and invasive disease by capsulated pneumococci. Infect Immun. 2001 Aug; 69(8):4870-3. PMID: 11447162.
    Citations: 62     Fields:    Translation:AnimalsCellsPHPublic Health
  94. Wang VJ, Kuppermann N, Malley R, Barnett ED, Meissner HC, Schmidt EV, Fleisher GR. Meningococcal disease among children who live in a large metropolitan area, 1981-1996. Clin Infect Dis. 2001 Apr 01; 32(7):1004-9. PMID: 11264027.
    Citations: 4     Fields:    Translation:HumansCells
  95. Glaser N, Barnett P, McCaslin I, Nelson D, Trainor J, Louie J, Kaufman F, Quayle K, Roback M, Malley R, Kuppermann N. Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. N Engl J Med. 2001 Jan 25; 344(4):264-9. PMID: 11172153.
    Citations: 96     Fields:    Translation:Humans
  96. Wang VJ, Malley R, Fleisher GR, Inkelis SH, Kuppermann N. Antibiotic treatment of children with unsuspected meningococcal disease. Arch Pediatr Adolesc Med. 2000 Jun; 154(6):556-60. PMID: 10850501.
    Citations: 2     Fields:    Translation:Humans
  97. Belko J, Wessel DL, Malley R. Endocarditis caused by Corynebacterium diphtheriae: case report and review of the literature. Pediatr Infect Dis J. 2000 Feb; 19(2):159-63. PMID: 10694006.
    Citations: 6     Fields:    Translation:HumansCells
  98. Stack AM, Malley R, Saladino RA, Montana JB, MacDonald KL, Molrine DC. Primary respiratory syncytial virus infection: pathology, immune response, and evaluation of vaccine challenge strains in a new mouse model. Vaccine. 2000 Jan 31; 18(14):1412-8. PMID: 10618539.
    Citations: 11     Fields:    Translation:AnimalsCells
  99. Woods GM, Doherty KV, Malley RC, Rist MJ, Muller HK. Carcinogen-modified dendritic cells induce immunosuppression by incomplete T-cell activation resulting from impaired antigen uptake and reduced CD86 expression. Immunology. 2000 Jan; 99(1):16-22. PMID: 10651936.
    Citations: 5     Fields:    Translation:AnimalsCells
  100. Malley R, Vernacchio L, Devincenzo J, Ramilo O, Dennehy PH, Meissner HC, Gruber WC, Jafri HS, Sanchez PJ, Macdonald K, Montana JB, Thompson CM, Ambrosino DM. Enzyme-linked immunosorbent assay to assess respiratory syncytial virus concentration and correlate results with inflammatory mediators in tracheal secretions. Pediatr Infect Dis J. 2000 Jan; 19(1):1-7. PMID: 10643842.
    Citations: 5     Fields:    Translation:HumansCellsCTClinical Trials
  101. Bruss JB, Malley R, Halperin S, Dobson S, Dhalla M, Mciver J, Siber GR. Treatment of severe pertussis: a study of the safety and pharmacology of intravenous pertussis immunoglobulin. Pediatr Infect Dis J. 1999 Jun; 18(6):505-11. PMID: 10391179.
    Citations: 13     Fields:    Translation:HumansCellsCTClinical Trials
  102. Feinerman IL, Tan HK, Roberson DW, Malley R, Kenna MA. Necrotizing fasciitis of the pharynx following adenotonsillectomy. Int J Pediatr Otorhinolaryngol. 1999 Apr 25; 48(1):1-7. PMID: 10365966.
    Citations: 3     Fields:    Translation:Humans
  103. Kuppermann N, Malley R, Inkelis SH, Fleisher GR. Clinical and hematologic features do not reliably identify children with unsuspected meningococcal disease. Pediatrics. 1999 Feb; 103(2):E20. PMID: 9925866.
    Citations: 5     Fields:    Translation:HumansCells
  104. Malley R, DeVincenzo J, Ramilo O, Dennehy PH, Meissner HC, Gruber WC, Sanchez PJ, Jafri H, Balsley J, Carlin D, Buckingham S, Vernacchio L, Ambrosino DM. Reduction of respiratory syncytial virus (RSV) in tracheal aspirates in intubated infants by use of humanized monoclonal antibody to RSV F protein. J Infect Dis. 1998 Dec; 178(6):1555-61. PMID: 9815203.
    Citations: 56     Fields:    Translation:HumansCellsCTClinical Trials
  105. Malley R, Inkelis SH, Coelho P, Huskins WC, Kuppermann N. Cerebrospinal fluid pleocytosis and prognosis in invasive meningococcal disease in children. Pediatr Infect Dis J. 1998 Oct; 17(10):855-9. PMID: 9802624.
    Citations:    Fields:    Translation:Humans
  106. Malley R, Stack AM, Ferretti ML, Thompson CM, Saladino RA. Anticapsular polysaccharide antibodies and nasopharyngeal colonization with Streptococcus pneumoniae in infant rats. J Infect Dis. 1998 Sep; 178(3):878-82. PMID: 9728564.
    Citations: 13     Fields:    Translation:AnimalsCells
  107. Stack AM, Malley R, Thompson CM, Kobzik L, Siber GR, Saladino RA. Minimum protective serum concentrations of pneumococcal anti-capsular antibodies in infant rats. J Infect Dis. 1998 Apr; 177(4):986-90. PMID: 9534972.
    Citations: 10     Fields:    Translation:AnimalsCells
  108. Malley R, Huskins WC, Kuppermann N. Multivariable predictive models for adverse outcome of invasive meningococcal disease in children. J Pediatr. 1996 Nov; 129(5):702-10. PMID: 8917237.
    Citations: 6     Fields:    Translation:Humans
  109. Cattanach L, Malley R, Rodin J. Psychologic and physiologic reactivity to stressors in eating disordered individuals. Psychosom Med. 1988 Nov-Dec; 50(6):591-9. PMID: 3237948.
    Citations: 9     Fields:    Translation:Humans
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Malley's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (451)
Explore
_
Co-Authors (48)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.