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Jerome Leonard Ackerman, PH.D.

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Overview
We develop multinuclear MR imaging and spectroscopy instrumentation and techniques for solid materials such as calcified tissues, polymers, ceramics and composites. Our materials focus includes bone mineral and matrix, atherosclerotic plaque, calcium phosphate biomaterials for bone repair, advanced engineering materials for medical and nonmedical applications, and the effect of bone-seeking pharmaceuticals (fluoride, bisphosphonates) on calcified tissues. Finally, we development interventional MR coils and devices for assessment and treatment of disease.

Mentoring
Continuously Optimized Automated Remote Tuning of Radiofrequency Coils: Application to MRI-Enhanced Endoscopy with Tracking-Imaging Probes
Summer, 05/01/07 - 08/31/07

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R44CA203276 (NEVO, EREZ) Sep 5, 2016 - Aug 31, 2018
    NIH/NCI
    Development and testing of MRI-mediated radiofrequency ablation system and probes
    Role: Principal Investigator
  2. R21DC014909 (MERFELD, DANIEL M) Mar 1, 2016 - Feb 28, 2018
    NIH/NIDCD
    Employing Magnetic Vestibular Stimulation (MVS) during Functional Imaging
    Role: Principal Investigator
  3. R43CA193134 (NEVO, EREZ) Jan 1, 2015 - Jun 30, 2015
    NIH/NCI
    Combined Optical and MR Microscopy System for Thin Tissue Histopathology Analysis
    Role: Principal Investigator
  4. S10RR023009 (ACKERMAN, JEROME L) Aug 1, 2006 - Jul 31, 2009
    NIH/NCRR
    15T Ultrahigh Field Horizontal MR Microscope for Mouse Imaging
    Role: Principal Investigator
  5. S10RR016811 (ACKERMAN, JEROME L) Apr 1, 2002 - Mar 31, 2003
    NIH/NCRR
    4.7T Magnetic Resonance Console
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Cohen O, Ackerman JL. Ex vivo mouse brain microscopy at 15T with loop-gap RF coil. Magn Reson Imaging. 2018 09; 51:1-6. PMID: 29679634.
    Citations:    Fields:    
  2. Cortes ARG, Cohen O, Zhao M, Aoki EM, Ribeiro RA, Abu Nada L, Costa C, Arita ES, Tamimi F, Ackerman JL. Assessment of alveolar bone marrow fat content using 15 T MRI. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 03; 125(3):244-249. PMID: 29292160.
    Citations:    Fields:    Translation:Humans
  3. Hue YK, Guimaraes AR, Cohen O, Nevo E, Roth A, Ackerman JL. Magnetic Resonance Mediated Radiofrequency Ablation. IEEE Trans Med Imaging. 2018 02; 37(2):417-427. PMID: 28922117.
    Citations:    Fields:    Translation:Animals
  4. Cohen O, Zhao M, Nevo E, Ackerman JL. MR Coagulation: A Novel Minimally Invasive Approach to Aneurysm Repair. J Vasc Interv Radiol. 2017 Nov; 28(11):1592-1598. PMID: 28802550.
    Citations:    Fields:    
  5. Wang H, Zhao M, Ackerman JL, Song Y. Saturation-inversion-recovery: A method for T1 measurement. J Magn Reson. 2017 01; 274:137-143. PMID: 27918897.
    Citations:    Fields:    
  6. Burns JA, Botelho JL, Bell JI, Faquin W, Lopez-Guerra G, Ackerman JL, Kobler JB. Injectable Aorta Tissue Paste for Vocal Fold Medialization: Residence Time, Biocompatibility, and Comparison to Predicates in a Guinea Pig Subdermal Model. Ann Otol Rhinol Laryngol. 2016 Nov; 125(11):900-911. PMID: 27440067.
    Citations:    Fields:    Translation:Animals
  7. Laurenti M, Al Subaie A, Abdallah MN, Cortes AR, Ackerman JL, Vali H, Basu K, Zhang YL, Murshed M, Strandman S, Zhu J, Makhoul N, Barralet JE, Tamimi F. Two-Dimensional Magnesium Phosphate Nanosheets Form Highly Thixotropic Gels That Up-Regulate Bone Formation. Nano Lett. 2016 08 10; 16(8):4779-87. PMID: 27280476.
    Citations: 1     Fields:    
  8. Huang C, Ouyang J, Reese TG, Wu Y, El Fakhri G, Ackerman JL. Continuous MR bone density measurement using water- and fat-suppressed projection imaging (WASPI) for PET attenuation correction in PET-MR. Phys Med Biol. 2015 Oct 21; 60(20):N369-81. PMID: 26405761.
    Citations: 1     Fields:    Translation:Humans
  9. Cortes AR, Abdala-Junior R, Weber M, Arita ES, Ackerman JL. Influence of pulse sequence parameters at 1.5?T and 3.0?T on MRI artefacts produced by metal-ceramic restorations. Dentomaxillofac Radiol. 2015; 44(8):20150136. PMID: 26084475.
    Citations: 2     Fields:    Translation:Humans
  10. Huang C, Ackerman JL, Petibon Y, Brady TJ, El Fakhri G, Ouyang J. MR-based motion correction for PET imaging using wired active MR microcoils in simultaneous PET-MR: phantom study. Med Phys. 2014 Apr; 41(4):041910. PMID: 24694141.
    Citations: 2     Fields:    
  11. Huang C, Ackerman JL, Petibon Y, Normandin MD, Brady TJ, El Fakhri G, Ouyang J. Motion compensation for brain PET imaging using wireless MR active markers in simultaneous PET-MR: phantom and non-human primate studies. Neuroimage. 2014 May 01; 91:129-37. PMID: 24418501.
    Citations: 5     Fields:    Translation:HumansAnimals
  12. Sprinkhuizen SM, Ackerman JL, Song YQ. Influence of bone marrow composition on measurements of trabecular microstructure using decay due to diffusion in the internal field MRI: simulations and clinical studies. Magn Reson Med. 2014 Dec; 72(6):1499-508. PMID: 24382681.
    Citations: 1     Fields:    Translation:HumansCells
  13. Saoiabi S, El Asri S, Laghzizil A, Masse S, Ackerman JL. Synthesis and Characterization of Nanoapatites Organofunctionalized with Aminotriphosphonate Agents. J Solid State Chem. 2012 Jan 01; 185:95-100. PMID: 22287800.
    Citations:    
  14. Mintzopoulos D, Ackerman JL, Song YQ. MRI of trabecular bone using a decay due to diffusion in the internal field contrast imaging sequence. J Magn Reson Imaging. 2011 Aug; 34(2):361-71. PMID: 21780229.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  15. Wu Y, Reese TG, Cao H, Hrovat MI, Toddes SP, Lemdiasov RA, Ackerman JL. Bone mineral imaged in vivo by 31P solid state MRI of human wrists. J Magn Reson Imaging. 2011 Sep; 34(3):623-33. PMID: 21761459.
    Citations: 11     Fields:    Translation:HumansAnimals
  16. Wu Y, Hrovat MI, Ackerman JL, Reese TG, Cao H, Ecklund K, Glimcher MJ. Bone matrix imaged in vivo by water- and fat-suppressed proton projection MRI (WASPI) of animal and human subjects. J Magn Reson Imaging. 2010 Apr; 31(4):954-63. PMID: 20373441.
    Citations: 15     Fields:    Translation:HumansAnimals
  17. Cao H, Nazarian A, Ackerman JL, Snyder BD, Rosenberg AE, Nazarian RM, Hrovat MI, Dai G, Mintzopoulos D, Wu Y. Quantitative (31)P NMR spectroscopy and (1)H MRI measurements of bone mineral and matrix density differentiate metabolic bone diseases in rat models. Bone. 2010 Jun; 46(6):1582-90. PMID: 20188225.
    Citations: 22     Fields:    Translation:Animals
  18. Wu Y, Hrovat MI, Ackerman J, Reese TA, Cao H, Ecklund K, Glimcher MJ. J Magn Reson Imaging. Bone matrix imaged in vivo by water and fat suppressed proton projection MRI (WASPI) of animal and human subjects. 2010; 31:954-963.
  19. Cho H, Ryu S, Ackerman JL, Song YQ. Visualization of inhomogeneous local magnetic field gradient due to susceptibility contrast. J Magn Reson. 2009 May; 198(1):88-93. PMID: 19231262.
    Citations: 2     Fields:    Translation:Cells
  20. Cao H, Ackerman JL, Hrovat MI, Graham L, Glimcher MJ, Wu Y. Quantitative bone matrix density measurement by water- and fat-suppressed proton projection MRI (WASPI) with polymer calibration phantoms. Magn Reson Med. 2008 Dec; 60(6):1433-43. PMID: 19025909.
    Citations: 22     Fields:    Translation:Animals
  21. Kuhn LT, Grynpas MD, Rey CC, Wu Y, Ackerman JL, Glimcher MJ. A comparison of the physical and chemical differences between cancellous and cortical bovine bone mineral at two ages. Calcif Tissue Int. 2008 Aug; 83(2):146-54. PMID: 18685796.
    Citations: 17     Fields:    Translation:AnimalsCells
  22. Wu Y, Dai G, Ackerman JL, Hrovat MI, Glimcher MJ, Snyder BD, Nazarian A, Chesler DA. Water- and fat-suppressed proton projection MRI (WASPI) of rat femur bone. Magn Reson Med. 2007 Mar; 57(3):554-67. PMID: 17326184.
    Citations: 20     Fields:    Translation:Animals
  23. Farrar CT, Wedeen VJ, Ackerman JL. Cylindrical meanderline radiofrequency coil for intravascular magnetic resonance studies of atherosclerotic plaque. Magn Reson Med. 2005 Jan; 53(1):226-30. PMID: 15690524.
    Citations: 4     Fields:    Translation:Humans
  24. Cho G, Segal E, Ackerman JL. Nuclear magnetic resonance-compatible furnace for high temperature MR imaging and spectroscopy in situ. J Magn Reson. 2004 Aug; 169(2):328-34. PMID: 15261630.
    Citations:    Fields:    Translation:Humans
  25. Wu Y, Ackerman JL, Chesler DA, Graham L, Wang Y, Glimcher MJ. Density of organic matrix of native mineralized bone measured by water- and fat-suppressed proton projection MRI. Magn Reson Med. 2003 Jul; 50(1):59-68. PMID: 12815679.
    Citations: 43     Fields:    Translation:AnimalsCells
  26. Cho G, Wu Y, Ackerman JL. Detection of hydroxyl ions in bone mineral by solid-state NMR spectroscopy. Science. 2003 May 16; 300(5622):1123-7. PMID: 12750514.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  27. Wu Y, Ackerman JL, Strawich ES, Rey C, Kim HM, Glimcher MJ. Phosphate ions in bone: identification of a calcium-organic phosphate complex by 31P solid-state NMR spectroscopy at early stages of mineralization. Calcif Tissue Int. 2003 May; 72(5):610-26. PMID: 12724829.
    Citations: 15     Fields:    Translation:AnimalsCells
  28. Wu Y, Ackerman JL, Kim HM, Rey C, Barroug A, Glimcher MJ. Nuclear magnetic resonance spin-spin relaxation of the crystals of bone, dental enamel, and synthetic hydroxyapatites. J Bone Miner Res. 2002 Mar; 17(3):472-80. PMID: 11874238.
    Citations: 30     Fields:    Translation:AnimalsCells
  29. Kuhn LT, Wu Y, Rey C, Gerstenfeld LC, Grynpas MD, Ackerman JL, Kim HM, Glimcher MJ. Structure, composition, and maturation of newly deposited calcium-phosphate crystals in chicken osteoblast cell cultures. J Bone Miner Res. 2000 Jul; 15(7):1301-9. PMID: 10893678.
    Citations: 7     Fields:    Translation:AnimalsCells
  30. Ramanathan C, Ackerman JL. Quantitative solid-state NMR imaging of synthetic calcium phosphate implants. Magn Reson Med. 1999 Jun; 41(6):1214-20. PMID: 10371454.
    Citations: 2     Fields:    Translation:HumansAnimals
  31. Pfleiderer B, Moore A, Tokareva E, Ackerman JL, Garrido L. Biodegradation of polysiloxanes in lymph nodes of rats measured with 29Si NMR. Biomaterials. 1999 Mar; 20(6):561-71. PMID: 10213359.
    Citations:    Fields:    Translation:AnimalsPHPublic Health
  32. Wu Y, Chesler DA, Glimcher MJ, Garrido L, Wang J, Jiang HJ, Ackerman JL. Multinuclear solid-state three-dimensional MRI of bone and synthetic calcium phosphates. Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1574-8. PMID: 9990066.
    Citations: 20     Fields:    Translation:Humans
  33. Wu Y, Ackerman JL, Chesler DA, Li J, Neer RM, Wang J, Glimcher MJ. Evaluation of bone mineral density using three-dimensional solid state phosphorus-31 NMR projection imaging. Calcif Tissue Int. 1998 Jun; 62(6):512-8. PMID: 9576979.
    Citations: 17     Fields:    Translation:Animals
  34. Ramanathan C, Ackerman JL. ADRF differential cross polarization spectroscopy of synthetic calcium phosphates and bone mineral. J Magn Reson. 1997 Jul; 127(1):26-35. PMID: 9245627.
    Citations: 1     Fields:    Translation:Animals
  35. Pfleiderer B, Campbell T, Hulka CA, Kopans DB, Lean CL, Ackerman JL, Brady TJ, Garrido L. Silicone gel-filled breast implants in women: findings at H-1 MR spectroscopy. Radiology. 1996 Dec; 201(3):777-83. PMID: 8939231.
    Citations: 2     Fields:    Translation:Humans
  36. Cheng LL, Lean CL, Bogdanova A, Wright SC, Ackerman JL, Brady TJ, Garrido L. Enhanced resolution of proton NMR spectra of malignant lymph nodes using magic-angle spinning. Magn Reson Med. 1996 Nov; 36(5):653-8. PMID: 8916014.
    Citations: 39     Fields:    Translation:Animals
  37. Garrido L, Bogdanova A, Cheng LL, Pfleiderer B, Tokareva E, Ackerman JL, Brady TJ. Detection of silicone migration and biodegradation with NMR. Curr Top Microbiol Immunol. 1996; 210:49-58. PMID: 8565588.
    Citations:    Fields:    Translation:HumansCells
  38. Garrido L, Ackerman JL. Re: Do patients with silicone-gel breast implants have elevated levels of blood silicon compared with control patients? Ann Plast Surg. 1995 Oct; 35(4):441-3. PMID: 8585692.
    Citations:    Fields:    Translation:Humans
  39. Pfleiderer B, Xu P, Ackerman JL, Garrido L. Study of aging of silicone rubber biomaterials with NMR. J Biomed Mater Res. 1995 Sep; 29(9):1129-40. PMID: 8567711.
    Citations: 2     Fields:    Translation:Animals
  40. Moore JR, Garrido L, Ackerman JL. Solid state phosphorus-31 magnetic resonance imaging of bone mineral. Magn Reson Med. 1995 Mar; 33(3):293-9. PMID: 7760697.
    Citations: 6     Fields:    Translation:HumansAnimals
  41. Wu Y, Glimcher MJ, Rey C, Ackerman JL. A unique protonated phosphate group in bone mineral not present in synthetic calcium phosphates. Identification by phosphorus-31 solid state NMR spectroscopy. J Mol Biol. 1994 Dec 09; 244(4):423-35. PMID: 7990131.
    Citations: 16     Fields:    Translation:Animals
  42. Pfleiderer B, Ackerman JL, Garrido L. Migration and biodegradation of free silicone from silicone gel-filled implants after long-term implantation. Magn Reson Med. 1993 Nov; 30(5):534-43. PMID: 8259053.
    Citations: 5     Fields:    Translation:AnimalsPHPublic Health
  43. Pfleiderer B, Ackerman JL, Garrido L. In vivo localized proton NMR spectroscopy of silicone. Magn Reson Med. 1993 Aug; 30(2):149-54. PMID: 8366795.
    Citations: 1     Fields:    Translation:Animals
  44. Garrido L, Pfleiderer B, Papisov M, Ackerman JL. In vivo degradation of silicones. Magn Reson Med. 1993 Jun; 29(6):839-43. PMID: 8350731.
    Citations: 5     Fields:    Translation:Animals
  45. Pfleiderer B, Ackerman JL, Garrido L. In vivo 1H chemical shift imaging of silicone implants. Magn Reson Med. 1993 May; 29(5):656-9. PMID: 8505902.
    Citations: 2     Fields:    Translation:Animals
  46. Ackerman JL, Raleigh DP, Glimcher MJ. Phosphorus-31 magnetic resonance imaging of hydroxyapatite: a model for bone imaging. Magn Reson Med. 1992 May; 25(1):1-11. PMID: 1317501.
    Citations: 7     Fields:    Translation:Humans
  47. Pearlman JD, Southern JF, Ackerman JL. Nuclear magnetic resonance microscopy of atheroma in human coronary arteries. Angiology. 1991 Sep; 42(9):726-33. PMID: 1928813.
    Citations: 2     Fields:    Translation:Humans
  48. Fisel CR, Ackerman JL, Buxton RB, Garrido L, Belliveau JW, Rosen BR, Brady TJ. MR contrast due to microscopically heterogeneous magnetic susceptibility: numerical simulations and applications to cerebral physiology. Magn Reson Med. 1991 Feb; 17(2):336-47. PMID: 2062208.
    Citations: 35     Fields:    Translation:Humans
  49. Wedeen VJ, Chao YS, Ackerman JL. Dynamic range compression in MRI by means of a nonlinear gradient pulse. Magn Reson Med. 1988 Mar; 6(3):287-95. PMID: 3362063.
    Citations: 5     Fields:    Translation:Humans
  50. Villringer A, Rosen BR, Belliveau JW, Ackerman JL, Lauffer RB, Buxton RB, Chao YS, Wedeen VJ, Brady TJ. Dynamic imaging with lanthanide chelates in normal brain: contrast due to magnetic susceptibility effects. Magn Reson Med. 1988 Feb; 6(2):164-74. PMID: 3367774.
    Citations: 77     Fields:    Translation:Animals
  51. Busse LJ, Thomas SR, Pratt RG, Clark LC, Ackerman JL, Samaratunga RC, Hoffmann RE. Deconvolution techniques for removing the effects of chemical shift in 19F nuclear magnetic resonance imaging of perfluorocarbon compounds. Med Phys. 1986 Jul-Aug; 13(4):518-24. PMID: 3736510.
    Citations: 1     Fields:    
  52. Thomas SR, Clark LC, Ackerman JL, Pratt RG, Hoffmann RE, Busse LJ, Kinsey RA, Samaratunga RC. MR imaging of the lung using liquid perfluorocarbons. J Comput Assist Tomogr. 1986 Jan-Feb; 10(1):1-9. PMID: 2935563.
    Citations: 2     Fields:    Translation:Animals
  53. Clark LC, Ackerman JL, Thomas SR, Millard RW, Hoffman RE, Pratt RG, Ragle-Cole H, Kinsey RA, Janakiraman R. Perfluorinated organic liquids and emulsions as biocompatible NMR imaging agents for 19F and dissolved oxygen. Adv Exp Med Biol. 1984; 180:835-45. PMID: 6534151.
    Citations: 8     Fields:    Translation:Animals
  54. Thomas SR, Ackerman JL, Kereiakes JG. Practical aspects involved in the design and set up of a 0.15 T, 6-coil resistive magnet, whole body NMR imaging facility. Magn Reson Imaging. 1984; 2(4):341-8. PMID: 6530937.
    Citations:    Fields:    
  55. Thomas SR, Ackerman JL, Goebel JR, Davis M, Kereiakes JG, Lin YY. Nuclear magnetic resonance imaging techniques as developed modestly within a university medical center environment: what can the small system contribute at this point? Magn Reson Imaging. 1982; 1(1):11-22. PMID: 6927190.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.