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profileJun Guo, PH.D.

TitleInstructor in Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Endocrine Unit, Thier 11
50 Blossom St
Boston MA 02114
Phone617/726-7650
Fax617/726-7543
vCardDownload vCard (login for email)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Li Y, Caballero D, Ponsetto J, Chen A, Zhu C, Guo J, Demay M, Jüppner H, Bergwitz C. Response of Npt2a knockout mice to dietary calcium and phosphorus. PLoS One. 2017; 12(4):e0176232. PMID: 28448530.
    View in: PubMed
  2. Guo JU, Bartel DP. RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria. Science. 2016 09 23; 353(6306). PMID: 27708011.
    View in: PubMed
  3. Guo J, Khatri A, Maeda A, Potts JT, Jüppner H, Gardella TJ. Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1-34) Peptide Fragment. J Bone Miner Res. 2017 Jan; 32(1):86-98. PMID: 27428040.
    View in: PubMed
  4. Zeng Y, Yao B, Shin J, Lin L, Kim N, Song Q, Liu S, Su Y, Guo JU, Huang L, Wan J, Wu H, Qian J, Cheng X, Zhu H, Ming GL, Jin P, Song H. Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression. Mol Cell. 2016 Jan 07; 61(1):153-60. PMID: 26711009; PMCID: PMC4779955 [Available on 01/07/17].
  5. Sinha P, Aarnisalo P, Chubb R, Poulton IJ, Guo J, Nachtrab G, Kimura T, Swami S, Saeed H, Chen M, Weinstein LS, Schipani E, Sims NA, Kronenberg HM, Wu JY. Loss of Gsa in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy. J Biol Chem. 2016 Jan 22; 291(4):1631-42. PMID: 26598522; PMCID: PMC4722446 [Available on 01/22/17].
  6. Sun J, Bonaguidi MA, Jun H, Guo JU, Sun GJ, Will B, Yang Z, Jang MH, Song H, Ming GL, Christian KM. A septo-temporal molecular gradient of sfrp3 in the dentate gyrus differentially regulates quiescent adult hippocampal neural stem cell activation. Mol Brain. 2015 Sep 04; 8:52. PMID: 26337530; PMCID: PMC4559945.
  7. Yu H, Su Y, Shin J, Zhong C, Guo JU, Weng YL, Gao F, Geschwind DH, Coppola G, Ming GL, Song H. Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. Nat Neurosci. 2015 Jun; 18(6):836-43. PMID: 25915473; PMCID: PMC4446239.
  8. Guo JU, Agarwal V, Guo H, Bartel DP. Expanded identification and characterization of mammalian circular RNAs. Genome Biol. 2014 Jul 29; 15(7):409. PMID: 25070500; PMCID: PMC4165365.
  9. Chagin AS, Vuppalapati KK, Kobayashi T, Guo J, Hirai T, Chen M, Offermanns S, Weinstein LS, Kronenberg HM. G-protein stimulatory subunit alpha and Gq/11a G-proteins are both required to maintain quiescent stem-like chondrocytes. Nat Commun. 2014 Apr 30; 5:3673. PMID: 24781502; PMCID: PMC4154354.
  10. Guo JU, Su Y, Shin JH, Shin J, Li H, Xie B, Zhong C, Hu S, Le T, Fan G, Zhu H, Chang Q, Gao Y, Ming GL, Song H. Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. Nat Neurosci. 2014 Feb; 17(2):215-22. PMID: 24362762; PMCID: PMC3970219.
  11. Guo J, Song L, Liu M, Segawa H, Miyamoto K, Bringhurst FR, Kronenberg HM, Jüppner H. Activation of a non-cAMP/PKA signaling pathway downstream of the PTH/PTHrP receptor is essential for a sustained hypophosphatemic response to PTH infusion in male mice. Endocrinology. 2013 May; 154(5):1680-9. PMID: 23515284; PMCID: PMC3628020.
  12. Yeo M, Berglund K, Hanna M, Guo JU, Kittur J, Torres MD, Abramowitz J, Busciglio J, Gao Y, Birnbaumer L, Liedtke WB. Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. Proc Natl Acad Sci U S A. 2013 Mar 12; 110(11):4315-20. PMID: 23440186; PMCID: PMC3600491.
  13. Jang MH, Bonaguidi MA, Kitabatake Y, Sun J, Song J, Kang E, Jun H, Zhong C, Su Y, Guo JU, Wang MX, Sailor KA, Kim JY, Gao Y, Christian KM, Ming GL, Song H. Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis. Cell Stem Cell. 2013 Feb 07; 12(2):215-23. PMID: 23395446; PMCID: PMC3569732.
  14. Song L, Liu M, Ono N, Bringhurst FR, Kronenberg HM, Guo J. Loss of wnt/ß-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes. J Bone Miner Res. 2012 Nov; 27(11):2344-58. PMID: 22729939; PMCID: PMC3474875.
  15. Guo J, Song L, Liu M, Mahon MJ. Fluorescent ligand-directed co-localization of the parathyroid hormone 1 receptor with the brush-border scaffold complex of the proximal tubule reveals hormone-dependent changes in ezrin immunoreactivity consistent with inactivation. Biochim Biophys Acta. 2012 Dec; 1823(12):2243-53. PMID: 23036889; PMCID: PMC3490049.
  16. Felling RJ, Guo JU, Song H. Neuronal activation and insight into the plasticity of DNA methylation. Epigenomics. 2012 Apr; 4(2):125-7. PMID: 22449183.
    View in: PubMed
  17. Kang E, Burdick KE, Kim JY, Duan X, Guo JU, Sailor KA, Jung DE, Ganesan S, Choi S, Pradhan D, Lu B, Avramopoulos D, Christian K, Malhotra AK, Song H, Ming GL. Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. Neuron. 2011 Nov 17; 72(4):559-71. PMID: 22099459; PMCID: PMC3222865.
  18. Guo JU, Ma DK, Mo H, Ball MP, Jang MH, Bonaguidi MA, Balazer JA, Eaves HL, Xie B, Ford E, Zhang K, Ming GL, Gao Y, Song H. Neuronal activity modifies the DNA methylation landscape in the adult brain. Nat Neurosci. 2011 Aug 28; 14(10):1345-51. PMID: 21874013; PMCID: PMC3183401.
  19. Guo JU, Su Y, Zhong C, Ming GL, Song H. Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond. Cell Cycle. 2011 Aug 15; 10(16):2662-8. PMID: 21811096; PMCID: PMC3219536.
  20. Guo JU, Su Y, Zhong C, Ming GL, Song H. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell. 2011 Apr 29; 145(3):423-34. PMID: 21496894; PMCID: PMC3088758.
  21. Kong Y, Si L, Zhu Y, Xu X, Corless CL, Flaherty KT, Li L, Li H, Sheng X, Cui C, Chi Z, Li S, Han M, Mao L, Lu A, Guo J. Large-scale analysis of KIT aberrations in Chinese patients with melanoma. Clin Cancer Res. 2011 Apr 01; 17(7):1684-91. PMID: 21325067.
    View in: PubMed
  22. Ma DK, Marchetto MC, Guo JU, Ming GL, Gage FH, Song H. Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nat Neurosci. 2010 Nov; 13(11):1338-44. PMID: 20975758; PMCID: PMC3324277.
  23. Guo J, Liu M, Yang D, Bouxsein ML, Thomas CC, Schipani E, Bringhurst FR, Kronenberg HM. Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH. Endocrinology. 2010 Aug; 151(8):3502-13. PMID: 20501677; PMCID: PMC2940537.
  24. Guo J, Liu M, Yang D, Bouxsein ML, Saito H, Galvin RJ, Kuhstoss SA, Thomas CC, Schipani E, Baron R, Bringhurst FR, Kronenberg HM. Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation. Cell Metab. 2010 Feb 03; 11(2):161-71. PMID: 20142103; PMCID: PMC2819982.
  25. Kim JY, Duan X, Liu CY, Jang MH, Guo JU, Pow-anpongkul N, Kang E, Song H, Ming GL. DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron. 2009 Sep 24; 63(6):761-73. PMID: 19778506; PMCID: PMC3075620.
  26. Ma DK, Guo JU, Ming GL, Song H. DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation. Cell Cycle. 2009 May 15; 8(10):1526-31. PMID: 19377292; PMCID: PMC2738863.
  27. Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul N, Flavell RA, Lu B, Ming GL, Song H. Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science. 2009 Feb 20; 323(5917):1074-7. PMID: 19119186; PMCID: PMC2726986.
  28. Fleming HE, Janzen V, Lo Celso C, Guo J, Leahy KM, Kronenberg HM, Scadden DT. Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell. 2008 Mar 06; 2(3):274-83. PMID: 18371452; PMCID: PMC2991120.
  29. Yang D, Guo J, Divieti P, Shioda T, Bringhurst FR. CBP/p300-interacting protein CITED1 modulates parathyroid hormone regulation of osteoblastic differentiation. Endocrinology. 2008 Apr; 149(4):1728-35. PMID: 18187554; PMCID: PMC2276703.
  30. Guo J, Chung UI, Yang D, Karsenty G, Bringhurst FR, Kronenberg HM. PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways. Dev Biol. 2006 Apr 01; 292(1):116-28. PMID: 16476422.
    View in: PubMed
  31. Yang D, Guo J, Divieti P, Bringhurst FR. Parathyroid hormone activates PKC-delta and regulates osteoblastic differentiation via a PLC-independent pathway. Bone. 2006 Apr; 38(4):485-96. PMID: 16325485.
    View in: PubMed
  32. Zhang SL, Guo J, Moini B, Ingelfinger JR. Angiotensin II stimulates Pax-2 in rat kidney proximal tubular cells: impact on proliferation and apoptosis. Kidney Int. 2004 Dec; 66(6):2181-92. PMID: 15569307.
    View in: PubMed
  33. MacLean HE, Guo J, Knight MC, Zhang P, Cobrinik D, Kronenberg HM. The cyclin-dependent kinase inhibitor p57(Kip2) mediates proliferative actions of PTHrP in chondrocytes. J Clin Invest. 2004 May; 113(9):1334-43. PMID: 15124025; PMCID: PMC398433.
  34. Kondo H, Guo J, Bringhurst FR. Cyclic adenosine monophosphate/protein kinase A mediates parathyroid hormone/parathyroid hormone-related protein receptor regulation of osteoclastogenesis and expression of RANKL and osteoprotegerin mRNAs by marrow stromal cells. J Bone Miner Res. 2002 Sep; 17(9):1667-79. PMID: 12211438.
    View in: PubMed
  35. Guo J, Chung UI, Kondo H, Bringhurst FR, Kronenberg HM. The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C. Dev Cell. 2002 Aug; 3(2):183-94. PMID: 12194850.
    View in: PubMed
  36. Guo J, Lanske B, Liu BY, Divieti P, Kronenberg HM, Bringhurst FR. Signal-selectivity of parathyroid hormone (PTH)/PTH-related peptide receptor-mediated regulation of differentiation in conditionally immortalized growth-plate chondrocytes. Endocrinology. 2001 Mar; 142(3):1260-8. PMID: 11181543.
    View in: PubMed
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