Harvard Catalyst Profiles

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Gary Eugene Gilbert, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. I01BX001352 (GILBERT, GARY E) Jan 1, 2012 - Mar 31, 2021
    Endothelial topography, phosphatidylserine, and procoagulant activity
    Role: Principal Investigator
  2. R01HL057867 (GILBERT, GARY E) Jun 1, 1998 - May 31, 2003
    Role: Principal Investigator
  3. K08HL002587 (GILBERT, GARY E) May 1, 1991 - Apr 30, 1996
    Role: Principal Investigator
  4. P01HL042443 (FURIE, BARBARA C) Apr 1, 1989 - Aug 31, 2005
    Role: Co-Principal Investigator
  5. F32HL007440 (GILBERT, GARY E) Jul 1, 1986
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gilbert GE. Factor VIII-antibody structure and membrane binding. Blood. 2021 May 27; 137(21):2866-2868. PMID: 34042979.
    Citations:    Fields:    
  2. Ahnström J, Gilbert GE. Factor V mutation illuminates the dominant anticoagulant role and importance of an unidentified platelet modifier. J Thromb Haemost. 2021 05; 19(5):1168-1170. PMID: 33880872.
    Citations:    Fields:    Translation:HumansCells
  3. Novakovic VA, Gilbert GE. Procoagulant activities of skeletal and cardiac muscle myosin depend on contaminating phospholipid. Blood. 2020 11 19; 136(21):2469-2472. PMID: 32604409.
    Citations: 3     Fields:    Translation:HumansAnimalsPHPublic Health
  4. Chatterjee M, Meeks S, Novakovic VA, Gilbert GE. Discordance between platelet-supported and vesicle-supported factor VIII activity in the presence of anti-C2 domain inhibitory antibodies. J Thromb Haemost. 2020 12; 18(12):3184-3193. PMID: 32558078.
    Citations:    Fields:    Translation:HumansCells
  5. Shi Q, Carman CV, Chen Y, Sage PT, Xue F, Liang XM, Gilbert GE. Unexpected enhancement of FVIII immunogenicity by endothelial expression in lentivirus-transduced and transgenic mice. Blood Adv. 2020 05 26; 4(10):2272-2285. PMID: 32453842.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Gilbert GE. The evolving understanding of factor VIII binding sites and implications for the treatment of hemophilia A. Blood Rev. 2019 01; 33:1-5. PMID: 29866493.
    Citations: 1     Fields:    Translation:HumansCells
  7. Sakurai Y, Hardy ET, Ahn B, Tran R, Fay ME, Ciciliano JC, Mannino RG, Myers DR, Qiu Y, Carden MA, Baldwin WH, Meeks SL, Gilbert GE, Jobe SM, Lam WA. A microengineered vascularized bleeding model that integrates the principal components of hemostasis. Nat Commun. 2018 02 06; 9(1):509. PMID: 29410404.
    Citations: 20     Fields:    Translation:HumansCells
  8. Gilbert GE. Inhibitory antibodies against factor VIII C1 domain. Blood. 2016 10 20; 128(16):2001-2002. PMID: 28157676.
    Citations:    Fields:    Translation:HumansCells
  9. Gao C, Xie R, Yu C, Ma R, Dong W, Meng H, Zhang Y, Si Y, Zhang Z, Novakovic V, Zhang Y, Kou J, Bi Y, Li B, Xie R, Gilbert GE, Zhou J, Shi J. Thrombotic Role of Blood and Endothelial Cells in Uremia through Phosphatidylserine Exposure and Microparticle Release. PLoS One. 2015; 10(11):e0142835. PMID: 26580207.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  10. Gilbert GE, Novakovic VA, Shi J, Rasmussen J, Pipe SW. Platelet binding sites for factor VIII in relation to fibrin and phosphatidylserine. Blood. 2015 Sep 03; 126(10):1237-44. PMID: 26162408.
    Citations: 9     Fields:    Translation:HumansCells
  11. Pantazatos D, Gessner CR, Woods VL, Gilbert GE. Changes in the Factor VIII C2 domain upon membrane binding determined by hydrogen-deuterium exchange MS. Biochem J. 2014 Aug 01; 461(3):443-51. PMID: 24814520.
    Citations: 4     Fields:    Translation:HumansCells
  12. Gilbert GE. Factor VIII inhibitor epitopes and an enigma. Blood. 2013 Dec 19; 122(26):4160-1. PMID: 24357711.
    Citations: 1     Fields:    Translation:Humans
  13. Nyegaard S, Novakovic VA, Rasmussen JT, Gilbert GE. Lactadherin inhibits secretory phospholipase A2 activity on pre-apoptotic leukemia cells. PLoS One. 2013; 8(10):e77143. PMID: 24194865.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  14. Gao C, Xie R, Li W, Zhou J, Liu S, Cao F, Liu Y, Ma R, Si Y, Liu Y, Bi Y, Gilbert GE, Shi J. Endothelial cell phagocytosis of senescent neutrophils decreases procoagulant activity. Thromb Haemost. 2013 Jun; 109(6):1079-90. PMID: 23571768.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  15. Gilbert GE, Novakovic VA, Kaufman RJ, Miao H, Pipe SW. Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity. Blood. 2012 Aug 30; 120(9):1923-32. PMID: 22613792.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  16. Nuzzio KM, Cullinan DB, Novakovic VA, Boettcher JM, Rienstra CM, Gilbert GE, Baleja JD. Backbone resonance assignments of the C2 domain of coagulation factor VIII. Biomol NMR Assign. 2013 Apr; 7(1):31-4. PMID: 22392338.
    Citations:    Fields:    Translation:Cells
  17. Xie R, Gao C, Li W, Zhu J, Novakovic V, Wang J, Ma R, Zhou J, Gilbert GE, Shi J. Phagocytosis by macrophages and endothelial cells inhibits procoagulant and fibrinolytic activity of acute promyelocytic leukemia cells. Blood. 2012 Mar 08; 119(10):2325-34. PMID: 22138513.
    Citations: 8     Fields:    Translation:HumansCells
  18. Otzen DE, Blans K, Wang H, Gilbert GE, Rasmussen JT. Lactadherin binds to phosphatidylserine-containing vesicles in a two-step mechanism sensitive to vesicle size and composition. Biochim Biophys Acta. 2012 Apr; 1818(4):1019-27. PMID: 21920348.
    Citations: 31     Fields:    Translation:AnimalsCells
  19. Gilbert GE, Mast AE. Curbing an inhibitor for hemostasis. Blood. 2011 May 19; 117(20):5277-8. PMID: 21596863.
    Citations:    Fields:    
  20. Novakovic VA, Cullinan DB, Wakabayashi H, Fay PJ, Baleja JD, Gilbert GE. Membrane-binding properties of the Factor VIII C2 domain. Biochem J. 2011 Apr 01; 435(1):187-96. PMID: 21210768.
    Citations: 11     Fields:    Translation:HumansCells
  21. Lü J, Pipe SW, Miao H, Jacquemin M, Gilbert GE. A membrane-interactive surface on the factor VIII C1 domain cooperates with the C2 domain for cofactor function. Blood. 2011 Mar 17; 117(11):3181-9. PMID: 21156843.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  22. Fu Y, Zhou J, Li H, Cao F, Su Y, Fan S, Li Y, Wang S, Li L, Gilbert GE, Shi J. Daunorubicin induces procoagulant activity of cultured endothelial cells through phosphatidylserine exposure and microparticles release. Thromb Haemost. 2010 Dec; 104(6):1235-41. PMID: 20886178.
    Citations: 11     Fields:    Translation:HumansCells
  23. Zhou J, Shi J, Hou J, Cao F, Zhang Y, Rasmussen JT, Heegaard CW, Gilbert GE. Phosphatidylserine exposure and procoagulant activity in acute promyelocytic leukemia. J Thromb Haemost. 2010 Apr; 8(4):773-82. PMID: 20102487.
    Citations: 20     Fields:    Translation:HumansCells
  24. Shcherbina A, Cooley J, Lutskiy MI, Benarafa C, Gilbert GE, Remold-O'Donnell E. WASP plays a novel role in regulating platelet responses dependent on alphaIIbbeta3 integrin outside-in signalling. Br J Haematol. 2010 Feb; 148(3):416-27. PMID: 19863535.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  25. Zhou J, Zheng Y, Shi J, Lu C, Hou J, Yu H, Qiao X, Qi S, Gilbert GE. Daunorubicin induces procoagulant response through phosphatidylserine exposure in red blood cells. Thromb Res. 2010 Feb; 125(2):178-83. PMID: 19800661.
    Citations: 3     Fields:    Translation:HumansCells
  26. Meems H, Meijer AB, Cullinan DB, Mertens K, Gilbert GE. Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity. Blood. 2009 Oct 29; 114(18):3938-46. PMID: 19687511.
    Citations: 26     Fields:    Translation:HumansCells
  27. Waehrens LN, Heegaard CW, Gilbert GE, Rasmussen JT. Bovine lactadherin as a calcium-independent imaging agent of phosphatidylserine expressed on the surface of apoptotic HeLa cells. J Histochem Cytochem. 2009 Oct; 57(10):907-14. PMID: 19546474.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  28. Zhou J, Liu S, Ma M, Hou J, Yu H, Lu C, Gilbert GE, Shi J. Procoagulant activity and phosphatidylserine of amniotic fluid cells. Thromb Haemost. 2009 May; 101(5):845-51. PMID: 19404537.
    Citations: 3     Fields:    Translation:Humans
  29. Gilbert GE. Where does von Willebrand factor go? Blood. 2008 Sep 01; 112(5):1549-50. PMID: 18725568.
    Citations:    Fields:    
  30. Shi J, Pipe SW, Rasmussen JT, Heegaard CW, Gilbert GE. Lactadherin blocks thrombosis and hemostasis in vivo: correlation with platelet phosphatidylserine exposure. J Thromb Haemost. 2008 Jul; 6(7):1167-74. PMID: 18485093.
    Citations: 32     Fields:    Translation:AnimalsCells
  31. Yeung T, Gilbert GE, Shi J, Silvius J, Kapus A, Grinstein S. Membrane phosphatidylserine regulates surface charge and protein localization. Science. 2008 Jan 11; 319(5860):210-3. PMID: 18187657.
    Citations: 396     Fields:    Translation:HumansAnimalsCells
  32. Shao C, Novakovic VA, Head JF, Seaton BA, Gilbert GE. Crystal structure of lactadherin C2 domain at 1.7A resolution with mutational and computational analyses of its membrane-binding motif. J Biol Chem. 2008 Mar 14; 283(11):7230-41. PMID: 18160406.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  33. Shi J, Shi Y, Waehrens LN, Rasmussen JT, Heegaard CW, Gilbert GE. Lactadherin detects early phosphatidylserine exposure on immortalized leukemia cells undergoing programmed cell death. Cytometry A. 2006 Dec 01; 69(12):1193-201. PMID: 17123296.
    Citations: 36     Fields:    Translation:HumansCells
  34. Gilbert GE. Use of microsphere-supported phospholipid membranes for analysis of protein-lipid interactions. Curr Protoc Cytom. 2005 Nov; Chapter 13:Unit13.3. PMID: 18770819.
    Citations: 1     Fields:    Translation:AnimalsCells
  35. Grant MA, Baikeev RF, Gilbert GE, Rigby AC. Lysine 5 and phenylalanine 9 of the factor IX omega-loop interact with phosphatidylserine in a membrane-mimetic environment. Biochemistry. 2004 Dec 14; 43(49):15367-78. PMID: 15581349.
    Citations: 2     Fields:    Translation:HumansCells
  36. Shi J, Heegaard CW, Rasmussen JT, Gilbert GE. Lactadherin binds selectively to membranes containing phosphatidyl-L-serine and increased curvature. Biochim Biophys Acta. 2004 Nov 17; 1667(1):82-90. PMID: 15533308.
    Citations: 60     Fields:    Translation:AnimalsCells
  37. Phillips JE, Lord ST, Gilbert GE. Fibrin stimulates platelets to increase factor VIIIa binding site expression. J Thromb Haemost. 2004 Oct; 2(10):1806-15. PMID: 15456493.
    Citations: 5     Fields:    Translation:HumansCells
  38. Gary E Gilbert Jialan Shi Christian W. Heegaard Jan T Rasmussen. Method, composition, and kit for detecting phosphatidylserine(PS) on cell membranes. 2004.
  39. Gary E Gilbert Jialan Shi. Use of lactadherin as an anticoagulant. 2003.
  40. Shi J, Gilbert GE. Lactadherin inhibits enzyme complexes of blood coagulation by competing for phospholipid-binding sites. Blood. 2003 Apr 01; 101(7):2628-36. PMID: 12517809.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  41. Gilbert GE, Kaufman RJ, Arena AA, Miao H, Pipe SW. Four hydrophobic amino acids of the factor VIII C2 domain are constituents of both the membrane-binding and von Willebrand factor-binding motifs. J Biol Chem. 2002 Feb 22; 277(8):6374-81. PMID: 11698391.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  42. Shi J, Gilbert GE, Kokubo Y, Ohashi T. Role of the liver in regulating numbers of circulating neutrophils. Blood. 2001 Aug 15; 98(4):1226-30. PMID: 11493474.
    Citations: 46     Fields:    Translation:AnimalsCells
  43. Blostein MD, Rigby AC, Furie BC, Furie B, Gilbert GE. Amphipathic helices support function of blood coagulation factor IXa. Biochemistry. 2000 Oct 03; 39(39):12000-6. PMID: 11009614.
    Citations: 2     Fields:    Translation:HumansCells
  44. Bendetowicz AV, Wise RJ, Gilbert GE. Collagen-bound von Willebrand factor has reduced affinity for factor VIII. J Biol Chem. 1999 Apr 30; 274(18):12300-7. PMID: 10212199.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  45. Gilbert GE, Arena AA. Unsaturated phospholipid acyl chains are required to constitute membrane binding sites for factor VIII. Biochemistry. 1998 Sep 29; 37(39):13526-35. PMID: 9753438.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  46. Bendetowicz AV, Morris JA, Wise RJ, Gilbert GE, Kaufman RJ. Binding of factor VIII to von willebrand factor is enabled by cleavage of the von Willebrand factor propeptide and enhanced by formation of disulfide-linked multimers. Blood. 1998 Jul 15; 92(2):529-38. PMID: 9657753.
    Citations: 13     Fields:    Translation:HumansCells
  47. Veeraraghavan S, Baleja JD, Gilbert GE. Structure and topography of the membrane-binding C2 domain of factor VIII in the presence of dodecylphosphocholine micelles. Biochem J. 1998 Jun 01; 332 ( Pt 2):549-55. PMID: 9601086.
    Citations: 3     Fields:    Translation:Cells
  48. Gilbert GE, Arena AA. Partial activation of the factor VIIIa-factor IXa enzyme complex by dihexanoic phosphatidylserine at submicellar concentrations. Biochemistry. 1997 Sep 02; 36(35):10768-76. PMID: 9271508.
    Citations: 3     Fields:    Translation:HumansCells
  49. Saenko EL, Shima M, Gilbert GE, Scandella D. Slowed release of thrombin-cleaved factor VIII from von Willebrand factor by a monoclonal and a human antibody is a novel mechanism for factor VIII inhibition. J Biol Chem. 1996 Nov 01; 271(44):27424-31. PMID: 8910322.
    Citations: 26     Fields:    Translation:HumansCells
  50. Gilbert GE, Arena AA. Activation of the factor VIIIa-factor IXa enzyme complex of blood coagulation by membranes containing phosphatidyl-L-serine. J Biol Chem. 1996 May 10; 271(19):11120-5. PMID: 8626656.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  51. Scandella D, Gilbert GE, Shima M, Nakai H, Eagleson C, Felch M, Prescott R, Rajalakshmi KJ, Hoyer LW, Saenko E. Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site. Blood. 1995 Sep 01; 86(5):1811-9. PMID: 7544643.
    Citations: 36     Fields:    Translation:HumansCells
  52. Gilbert GE, Arena AA. Phosphatidylethanolamine induces high affinity binding sites for factor VIII on membranes containing phosphatidyl-L-serine. J Biol Chem. 1995 Aug 04; 270(31):18500-5. PMID: 7629178.
    Citations: 10     Fields:    Translation:HumansCells
  53. Gilbert GE, Baleja JD. Membrane-binding peptide from the C2 domain of factor VIII forms an amphipathic structure as determined by NMR spectroscopy. Biochemistry. 1995 Mar 07; 34(9):3022-31. PMID: 7893714.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  54. Gilbert GE, Drinkwater D. Specific membrane binding of factor VIII is mediated by O-phospho-L-serine, a moiety of phosphatidylserine. Biochemistry. 1993 Sep 21; 32(37):9577-85. PMID: 8373765.
    Citations: 22     Fields:    Translation:HumansCells
  55. Bardelle C, Furie B, Furie BC, Gilbert GE. Membrane binding kinetics of factor VIII indicate a complex binding process. J Biol Chem. 1993 Apr 25; 268(12):8815-24. PMID: 8473326.
    Citations: 15     Fields:    Translation:HumansAnimals
  56. Gilbert GE, Drinkwater D, Barter S, Clouse SB. Specificity of phosphatidylserine-containing membrane binding sites for factor VIII. Studies with model membranes supported by glass microspheres (lipospheres). J Biol Chem. 1992 Aug 05; 267(22):15861-8. PMID: 1639816.
    Citations: 15     Fields:    Translation:HumansCells
  57. Gilbert GE, Sims PJ, Wiedmer T, Furie B, Furie BC, Shattil SJ. Platelet-derived microparticles express high affinity receptors for factor VIII. J Biol Chem. 1991 Sep 15; 266(26):17261-8. PMID: 1654328.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  58. Larsen E, Palabrica T, Sajer S, Gilbert GE, Wagner DD, Furie BC, Furie B. PADGEM-dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15). Cell. 1990 Nov 02; 63(3):467-74. PMID: 1699666.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  59. Gilbert GE, Furie BC, Furie B. Binding of human factor VIII to phospholipid vesicles. J Biol Chem. 1990 Jan 15; 265(2):815-22. PMID: 2104832.
    Citations: 25     Fields:    Translation:HumansCells
  60. Larsen E, Celi A, Gilbert GE, Furie BC, Erban JK, Bonfanti R, Wagner DD, Furie B. PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell. 1989 Oct 20; 59(2):305-12. PMID: 2478294.
    Citations: 170     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.