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Christy Lynn Lavine, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mandizvo T, Gumede N, Ndlovu B, Ndlovu S, Mann JK, Chopera DR, Singh L, Dong KL, Walker BD, Ndhlovu ZM, Lavine CL, Seaman MS, Gounder K, Ndung'u T. Subtle Longitudinal Alterations in Env Sequence Potentiate Differences in Sensitivity to Broadly Neutralizing Antibodies following Acute HIV-1 Subtype C Infection. J Virol. 2022 12 21; 96(24):e0127022. PMID: 36453881; PMCID: PMC9769376.
    Citations:    Fields:    Translation:HumansCells
  2. Seaman MS, Siedner MJ, Boucau J, Lavine CL, Ghantous F, Liew MY, Mathews JI, Singh A, Marino C, Regan J, Uddin R, Choudhary MC, Flynn JP, Chen G, Stuckwisch AM, Lipiner T, Kittilson A, Melberg M, Gilbert RF, Reynolds Z, Iyer SL, Chamberlin GC, Vyas TD, Vyas JM, Goldberg MB, Luban J, Li JZ, Barczak AK, Lemieux JE. Vaccine breakthrough infection leads to distinct profiles of neutralizing antibody responses by SARS-CoV-2 variant. JCI Insight. 2022 10 10; 7(19). PMID: 36214224; PMCID: PMC9675445.
    Citations: 3     Fields:    Translation:HumansCells
  3. Zhang J, Tang W, Gao H, Lavine CL, Shi W, Peng H, Zhu H, Anand K, Kosikova M, Kwon HJ, Tong P, Gautam A, Rits-Volloch S, Wang S, Mayer ML, Wesemann DR, Seaman MS, Lu J, Xiao T, Xie H, Chen B. Structural and functional characteristics of SARS-CoV-2 Omicron subvariant BA.2 spike. bioRxiv. 2022 Apr 28. PMID: 35547850; PMCID: PMC9094093.
    Citations:    
  4. Zhang J, Cai Y, Lavine CL, Peng H, Zhu H, Anand K, Tong P, Gautam A, Mayer ML, Rits-Volloch S, Wang S, Sliz P, Wesemann DR, Yang W, Seaman MS, Lu J, Xiao T, Chen B. Structural and functional impact by SARS-CoV-2 Omicron spike mutations. Cell Rep. 2022 04 26; 39(4):110729. PMID: 35452593; PMCID: PMC8995406.
    Citations: 12     Fields:    Translation:HumansCells
  5. Seaman MS, Siedner MJ, Boucau J, Lavine CL, Ghantous F, Liew MY, Mathews J, Singh A, Marino C, Regan J, Uddin R, Choudhary MC, Flynn JP, Chen G, Stuckwisch AM, Lipiner T, Kittilson A, Melberg M, Gilbert RF, Reynolds Z, Iyer SL, Chamberlin GC, Vyas TD, Vyas JM, Goldberg MB, Luban J, Li JZ, Barczak AK, Lemieux JE. Vaccine Breakthrough Infection with the SARS-CoV-2 Delta or Omicron (BA.1) Variant Leads to Distinct Profiles of Neutralizing Antibody Responses. medRxiv. 2022 Mar 03. PMID: 35262094; PMCID: PMC8902886.
    Citations: 1     
  6. Zhang J, Xiao T, Cai Y, Lavine CL, Peng H, Zhu H, Anand K, Tong P, Gautam A, Mayer ML, Walsh RM, Rits-Volloch S, Wesemann DR, Yang W, Seaman MS, Lu J, Chen B. Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant. Science. 2021 Dec 10; 374(6573):1353-1360. PMID: 34698504.
    Citations: 69     Fields:    Translation:HumansCells
  7. Zhang J, Xiao T, Cai Y, Lavine CL, Peng H, Zhu H, Anand K, Tong P, Gautam A, Mayer ML, Walsh RM, Rits-Volloch S, Wesemann DR, Yang W, Seaman MS, Lu J, Chen B. Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant. bioRxiv. 2021 Aug 17. PMID: 34426810; PMCID: PMC8382121.
    Citations:    
  8. Tong P, Gautam A, Windsor IW, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Storm N, Malsick LE, Honko AN, Lelis FJN, Habibi S, Jenni S, Cai Y, Rennick LJ, Duprex WP, McCarthy KR, Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt AG, Chen B, Neuberg D, Bajic G, Harrison SC, Wesemann DR. Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike. Cell. 2021 09 16; 184(19):4969-4980.e15. PMID: 34332650; PMCID: PMC8299219.
    Citations: 31     Fields:    
  9. Cai Y, Zhang J, Xiao T, Lavine CL, Rawson S, Peng H, Zhu H, Anand K, Tong P, Gautam A, Lu S, Sterling SM, Walsh RM, Rits-Volloch S, Lu J, Wesemann DR, Yang W, Seaman MS, Chen B. Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants. Science. 2021 08 06; 373(6555):642-648. PMID: 34168070; PMCID: PMC9245151.
    Citations: 70     Fields:    Translation:HumansCells
  10. Cai Y, Zhang J, Xiao T, Lavine CL, Rawson S, Peng H, Zhu H, Anand K, Tong P, Gautam A, Lu S, Sterling SM, Walsh RM, Rits-Volloch S, Lu J, Wesemann DR, Yang W, Seaman MS, Chen B. Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants. bioRxiv. 2021 Apr 14. PMID: 33880477; PMCID: PMC8057242.
    Citations:    
  11. Tong P, Gautam A, Windsor I, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Lelis FJN, Habibi S, Cai Y, Rennick LJ, Duprex WP, McCarthy KR, Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt AG, Chen B, Neuberg D, Bajic G, Harrison SC, Wesemann DR. Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike. bioRxiv. 2021 Mar 10. PMID: 33758863; PMCID: PMC7987022.
    Citations:    
  12. Xiao T, Lu J, Zhang J, Johnson RI, McKay LGA, Storm N, Lavine CL, Peng H, Cai Y, Rits-Volloch S, Lu S, Quinlan BD, Farzan M, Seaman MS, Griffiths A, Chen B. A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent. Nat Struct Mol Biol. 2021 02; 28(2):202-209. PMID: 33432247; PMCID: PMC7895301.
    Citations: 32     Fields:    Translation:HumansCells
  13. Lorenzi JCC, Mendoza P, Cohen YZ, Nogueira L, Lavine C, Sapiente J, Wiatr M, Mugo NR, Mujugira A, Delany S, Lingappa J, Celum C, Seaman MS, Caskey M, Nussenzweig MC. Neutralizing Activity of Broadly Neutralizing anti-HIV-1 Antibodies against Primary African Isolates. J Virol. 2020 Dec 09. PMID: 33298542.
    Citations: 11     Fields:    
  14. Chen Y, Zuiani A, Fischinger S, Mullur J, Atyeo C, Travers M, Lelis FJN, Pullen KM, Martin H, Tong P, Gautam A, Habibi S, Bensko J, Gakpo D, Feldman J, Hauser BM, Caradonna TM, Cai Y, Burke JS, Lin J, Lederer JA, Lam EC, Lavine CL, Seaman MS, Chen B, Schmidt AG, Balazs AB, Lauffenburger DA, Alter G, Wesemann DR. Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production. Cell. 2020 12 10; 183(6):1496-1507.e16. PMID: 33171099.
    Citations: 93     Fields:    Translation:HumansCells
  15. Xiao T, Lu J, Zhang J, Johnson RI, McKay LGA, Storm N, Lavine CL, Peng H, Cai Y, Rits-Volloch S, Lu S, Quinlan BD, Farzan M, Seaman MS, Griffiths A, Chen B. A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro. bioRxiv. 2020 Sep 18. PMID: 32995768.
    Citations: 1     
  16. Tartaglia LJ, Gupte S, Pastores KC, Trott S, Abbink P, Mercado NB, Li Z, Liu PT, Borducchi EN, Chandrashekar A, Bondzie EA, Hamza V, Kordana N, Mahrokhian S, Lavine CL, Seaman MS, Li H, Shaw GM, Barouch DH. Differential Outcomes following Optimization of Simian-Human Immunodeficiency Viruses from Clades AE, B, and C. J Virol. 2020 05 04; 94(10). PMID: 32132241.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  17. Andrade VM, Mavian C, Babic D, Cordeiro T, Sharkey M, Barrios L, Brander C, Martinez-Picado J, Dalmau J, Llano A, Li JZ, Jacobson J, Lavine CL, Seaman MS, Salemi M, Stevenson M. A minor population of macrophage-tropic HIV-1 variants is identified in recrudescing viremia following analytic treatment interruption. Proc Natl Acad Sci U S A. 2020 05 05; 117(18):9981-9990. PMID: 32300019.
    Citations: 23     Fields:    Translation:HumansCells
  18. Xiao T, Frey G, Fu Q, Lavine CL, Scott DA, Seaman MS, Chou JJ, Chen B. HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes. Nat Chem Biol. 2020 05; 16(5):529-537. PMID: 32152540.
    Citations: 9     Fields:    Translation:HumansCells
  19. Bricault CA, Yusim K, Seaman MS, Yoon H, Theiler J, Giorgi EE, Wagh K, Theiler M, Hraber P, Macke JP, Kreider EF, Learn GH, Hahn BH, Scheid JF, Kovacs JM, Shields JL, Lavine CL, Ghantous F, Rist M, Bayne MG, Neubauer GH, McMahan K, Peng H, Chéneau C, Jones JJ, Zeng J, Ochsenbauer C, Nkolola JP, Stephenson KE, Chen B, Gnanakaran S, Bonsignori M, Williams LD, Haynes BF, Doria-Rose N, Mascola JR, Montefiori DC, Barouch DH, Korber B. HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design. Cell Host Microbe. 2019 08 14; 26(2):296. PMID: 31415756.
    Citations: 12     Fields:    
  20. Bricault CA, Yusim K, Seaman MS, Yoon H, Theiler J, Giorgi EE, Wagh K, Theiler M, Hraber P, Macke JP, Kreider EF, Learn GH, Hahn BH, Scheid JF, Kovacs JM, Shields JL, Lavine CL, Ghantous F, Rist M, Bayne MG, Neubauer GH, McMahan K, Peng H, Chéneau C, Jones JJ, Zeng J, Ochsenbauer C, Nkolola JP, Stephenson KE, Chen B, Gnanakaran S, Bonsignori M, Williams LD, Haynes BF, Doria-Rose N, Mascola JR, Montefiori DC, Barouch DH, Korber B. HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design. Cell Host Microbe. 2019 01 09; 25(1):59-72.e8. PMID: 30629920.
    Citations: 40     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  21. Lorenzi JC, Cohen YZ, Cohn LB, Kreider EF, Barton JP, Learn GH, Oliveira T, Lavine CL, Horwitz JA, Settler A, Jankovic M, Seaman MS, Chakraborty AK, Hahn BH, Caskey M, Nussenzweig MC. Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA. Proc Natl Acad Sci U S A. 2016 12 06; 113(49):E7908-E7916. PMID: 27872306; PMCID: PMC5150408.
    Citations: 104     Fields:    
  22. Tartaglia LJ, Chang HW, Lee BC, Abbink P, Ng'ang'a D, Boyd M, Lavine CL, Lim SY, Sanisetty S, Whitney JB, Seaman MS, Rolland M, Tovanabutra S, Ananworanich J, Robb ML, Kim JH, Michael NL, Barouch DH. Production of Mucosally Transmissible SHIV Challenge Stocks from HIV-1 Circulating Recombinant Form 01_AE env Sequences. PLoS Pathog. 2016 Feb; 12(2):e1005431. PMID: 26849216; PMCID: PMC4743977.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  23. Cohen YZ, Lavine CL, Miller CA, Garrity J, Carey BR, Seaman MS. Glycan-Dependent Neutralizing Antibodies Are Frequently Elicited in Individuals Chronically Infected with HIV-1 Clade B or C. AIDS Res Hum Retroviruses. 2015 Nov; 31(11):1192-201. PMID: 26149894; PMCID: PMC4651021.
    Citations: 3     Fields:    Translation:Cells
  24. Barouch DH, Alter G, Broge T, Linde C, Ackerman ME, Brown EP, Borducchi EN, Smith KM, Nkolola JP, Liu J, Shields J, Parenteau L, Whitney JB, Abbink P, Ng'ang'a DM, Seaman MS, Lavine CL, Perry JR, Li W, Colantonio AD, Lewis MG, Chen B, Wenschuh H, Reimer U, Piatak M, Lifson JD, Handley SA, Virgin HW, Koutsoukos M, Lorin C, Voss G, Weijtens M, Pau MG, Schuitemaker H. Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys. Science. 2015 Jul 17; 349(6245):320-4. PMID: 26138104.
    Citations: 196     Fields:    Translation:AnimalsCells
  25. Bricault CA, Kovacs JM, Nkolola JP, Yusim K, Giorgi EE, Shields JL, Perry J, Lavine CL, Cheung A, Ellingson-Strouss K, Rademeyer C, Gray GE, Williamson C, Stamatatos L, Seaman MS, Korber BT, Chen B, Barouch DH. A multivalent clade C HIV-1 Env trimer cocktail elicits a higher magnitude of neutralizing antibodies than any individual component. J Virol. 2015 Mar; 89(5):2507-19. PMID: 25540368; PMCID: PMC4325749.
    Citations: 25     Fields:    Translation:AnimalsCellsPHPublic Health
  26. Chang HW, Tartaglia LJ, Whitney JB, Lim SY, Sanisetty S, Lavine CL, Seaman MS, Rademeyer C, Williamson C, Ellingson-Strouss K, Stamatatos L, Kublin J, Barouch DH. Generation and evaluation of clade C simian-human immunodeficiency virus challenge stocks. J Virol. 2015 Feb; 89(4):1965-74. PMID: 25473043; PMCID: PMC4338880.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  27. Asmal M, Luedemann C, Lavine CL, Mach LV, Balachandran H, Brinkley C, Denny TN, Lewis MG, Anderson H, Pal R, Sok D, Le K, Pauthner M, Hahn BH, Shaw GM, Seaman MS, Letvin NL, Burton DR, Sodroski JG, Haynes BF, Santra S. Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes. Virology. 2015 Jan 15; 475:37-45. PMID: 25462344.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  28. Li H, Stephenson KE, Kang ZH, Lavine CL, Seaman MS, Barouch DH. Common features of mucosal and peripheral antibody responses elicited by candidate HIV-1 vaccines in rhesus monkeys. J Virol. 2014 Nov; 88(22):13510-5. PMID: 25210178.
    Citations: 5     Fields:    Translation:AnimalsCells
  29. Sixsmith JD, Panas MW, Lee S, Gillard GO, White K, Lifton MA, Balachandran H, Mach L, Miller JP, Lavine C, DeMarco CT, Tomaras GD, Gee C, Porcelli SA, Larsen MH, Frothingham R, Schmitz JE, Jacobs WR, Haynes BF, Letvin NL, Korioth-Schmitz B. Recombinant Mycobacterium bovis bacillus Calmette-Guérin vectors prime for strong cellular responses to simian immunodeficiency virus gag in rhesus macaques. Clin Vaccine Immunol. 2014 Oct; 21(10):1385-95. PMID: 25080550.
    Citations: 9     Fields:    Translation:AnimalsCells
  30. DeMuth PC, Li AV, Abbink P, Liu J, Li H, Stanley KA, Smith KM, Lavine CL, Seaman MS, Kramer JA, Miller AD, Abraham W, Suh H, Elkhader J, Hammond PT, Barouch DH, Irvine DJ. Vaccine delivery with microneedle skin patches in nonhuman primates. Nat Biotechnol. 2013 Dec; 31(12):1082-5. PMID: 24316643.
    Citations: 29     Fields:    Translation:HumansAnimals
  31. Lavine CL, Lao S, Montefiori DC, Haynes BF, Sodroski JG, Yang X. High-mannose glycan-dependent epitopes are frequently targeted in broad neutralizing antibody responses during human immunodeficiency virus type 1 infection. J Virol. 2012 Feb; 86(4):2153-64. PMID: 22156525.
    Citations: 40     Fields:    Translation:HumansCells
  32. Bina XR, Lavine CL, Miller MA, Bina JE. The AcrAB RND efflux system from the live vaccine strain of Francisella tularensis is a multiple drug efflux system that is required for virulence in mice. FEMS Microbiol Lett. 2008 Feb; 279(2):226-33. PMID: 18179581.
    Citations: 33     Fields:    Translation:AnimalsCells
  33. Thakran S, Li H, Lavine CL, Miller MA, Bina JE, Bina XR, Re F. Identification of Francisella tularensis lipoproteins that stimulate the toll-like receptor (TLR) 2/TLR1 heterodimer. J Biol Chem. 2008 Feb 15; 283(7):3751-60. PMID: 18079113.
    Citations: 63     Fields:    Translation:HumansCells
  34. Lavine CL, Clinton SR, Angelova-Fischer I, Marion TN, Bina XR, Bina JE, Whitt MA, Miller MA. Immunization with heat-killed Francisella tularensis LVS elicits protective antibody-mediated immunity. Eur J Immunol. 2007 Nov; 37(11):3007-20. PMID: 17960662.
    Citations: 21     Fields:    Translation:AnimalsCellsPHPublic Health
  35. Klas SD, Lavine CL, Whitt MA, Miller MA. IL-12-assisted immunization against Listeria monocytogenes using replication-restricted VSV-based vectors. Vaccine. 2006 Feb 27; 24(9):1451-61. PMID: 16310294.
    Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
  36. Miller MA, Lavine CL, Klas SD, Pfeffer LM, Whitt MA. Recombinant replication-restricted VSV as an expression vector for murine cytokines. Protein Expr Purif. 2004 Jan; 33(1):92-103. PMID: 14680966.
    Citations: 4     Fields:    Translation:AnimalsCells
  37. Miller MA, Skeen MJ, Lavine CL, Kirk Ziegler H. IL-12-assisted immunization generates CD4+ T cell-mediated immunity to Listeria monocytogenes. Cell Immunol. 2003 Mar; 222(1):1-14. PMID: 12798303.
    Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
  38. Davis RL, Lavine CL, Arredondo MA, McMahon P, Tenner TE. Differential indicators of diabetes-induced oxidative stress in New Zealand White rabbits: role of dietary vitamin E supplementation. Int J Exp Diabetes Res. 2002 Jul-Sep; 3(3):185-92. PMID: 12458660; PMCID: PMC2478584.
    Citations: 1     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.