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Carol Anne Paronis, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DA047574 (PARONIS, CAROL A) Jan 1, 2019 - Nov 30, 2021
    In vivo characterization of opioid biased agonists
    Role: Principal Investigator
  2. R01DA043700 (PARONIS, CAROL A) Sep 30, 2018 - Jun 30, 2023
    Behavioral Pharmacology of Synthetic Cannabinoids
    Role: Principal Investigator
  3. R21DA035411 (PARONIS, CAROL A) Jun 1, 2014 - May 31, 2017
    Cannabinoid Dependence Resubmission
    Role: Principal Investigator
  4. R01DA015723 (PARONIS, CAROL A) May 14, 2004 - Mar 31, 2010
    Opioids: Relative Reinforcing Strength and Dependence
    Role: Principal Investigator
  5. R29DA011453 (PARONIS, CAROL A) Sep 30, 1997 - Aug 31, 2003
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wakeford AGP, Sherwood AM, Prisinzano TE, Bergman J, Kohut SJ, Paronis CA. Discriminative-Stimulus Effects of Synthetic Cathinones in Squirrel Monkeys. Int J Neuropsychopharmacol. 2021 08 20; 24(8):656-665. PMID: 33909067.
    Citations:    Fields:    
  2. de Moura FB, Sherwood A, Prisinzano TE, Paronis CA, Bergman J, Kohut SJ. Reinforcing effects of synthetic cathinones in rhesus monkeys: Dose-response and behavioral economic analyses. Pharmacol Biochem Behav. 2021 03; 202:173112. PMID: 33444603.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. Wang M, Irvin TC, Herdman CA, Hanna RD, Hassan SA, Lee YS, Kaska S, Crowley RS, Prisinzano TE, Withey SL, Paronis CA, Bergman J, Inan S, Geller EB, Adler MW, Kopajtic TA, Katz JL, Chadderdon AM, Traynor JR, Jacobson AE, Rice KC. The Intriguing Effects of Substituents in the N-Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of "Tail Wags Dog" Experiments. Molecules. 2020 Jun 06; 25(11). PMID: 32517185.
    Citations: 3     Fields:    Translation:AnimalsCells
  4. Withey SL, Spealman RD, Bergman J, Paronis CA. Behavioral Effects of Opioid Full and Partial Agonists During Chronic Buprenorphine Treatment. J Pharmacol Exp Ther. 2019 11; 371(2):544-554. PMID: 31413139.
    Citations: 1     Fields:    Translation:Animals
  5. Chopda GR, Nikas SP, Sharma R, Kulkarni S, Makriyannis A, Paronis CA. Cannabinoid-induced lower lip retraction in rats. Psychopharmacology (Berl). 2019 Apr; 236(4):1199-1206. PMID: 30460515.
    Citations:    Fields:    Translation:Animals
  6. Withey SL, Paronis CA, Bergman J. Concurrent Assessment of the Antinociceptive and Behaviorally Disruptive Effects of Opioids in Squirrel Monkeys. J Pain. 2018 07; 19(7):728-740. PMID: 29477761.
    Citations: 9     Fields:    Translation:Animals
  7. Paronis CA, Chopda GR, Vemuri K, Zakarian AS, Makriyannis A, Bergman J. Long-Lasting In Vivo Effects of the Cannabinoid CB1 Antagonist AM6538. J Pharmacol Exp Ther. 2018 03; 364(3):485-493. PMID: 29311110.
    Citations: 1     Fields:    Translation:HumansAnimals
  8. Kulkarni S, Nikas SP, Sharma R, Jiang S, Paronis CA, Leonard MZ, Zhang B, Honrao C, Mallipeddi S, Raghav JG, Benchama O, Järbe TU, Bergman J, Makriyannis A. Novel C-Ring-Hydroxy-Substituted Controlled Deactivation Cannabinergic Analogues. J Med Chem. 2016 07 28; 59(14):6903-19. PMID: 27367336.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  9. Chopda GR, Parge V, Thakur GA, Gatley SJ, Makriyannis A, Paronis CA. Tolerance to the Diuretic Effects of Cannabinoids and Cross-Tolerance to a ?-Opioid Agonist in THC-Treated Mice. J Pharmacol Exp Ther. 2016 08; 358(2):334-41. PMID: 27231154.
    Citations: 3     Fields:    Translation:Animals
  10. Nikas SP, Sharma R, Paronis CA, Kulkarni S, Thakur GA, Hurst D, Wood JT, Gifford RS, Rajarshi G, Liu Y, Raghav JG, Guo JJ, Järbe TU, Reggio PH, Bergman J, Makriyannis A. Probing the carboxyester side chain in controlled deactivation (-)-d(8)-tetrahydrocannabinols. J Med Chem. 2015 Jan 22; 58(2):665-81. PMID: 25470070.
    Citations: 6     Fields:    Translation:HumansCells
  11. Hudzik TJ, Pietras MR, Caccese R, Bui KH, Yocca F, Paronis CA, Swedberg MD. Effects of the d opioid agonist AZD2327 upon operant behaviors and assessment of its potential for abuse. Pharmacol Biochem Behav. 2014 Sep; 124:48-57. PMID: 24857840.
    Citations: 6     Fields:    Translation:HumansAnimals
  12. Sharma R, Nikas SP, Paronis CA, Wood JT, Halikhedkar A, Guo JJ, Thakur GA, Kulkarni S, Benchama O, Raghav JG, Gifford RS, Järbe TU, Bergman J, Makriyannis A. Controlled-deactivation cannabinergic ligands. J Med Chem. 2013 Dec 27; 56(24):10142-57. PMID: 24286207.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  13. Chopda GR, Vemuri VK, Sharma R, Thakur GA, Makriyannis A, Paronis CA. Diuretic effects of cannabinoid agonists in mice. Eur J Pharmacol. 2013 Dec 05; 721(1-3):64-9. PMID: 24099963.
    Citations: 14     Fields:    Translation:Animals
  14. Paronis CA. Ethanol self-administration in rats responding under concurrent schedules for milk or ethanol plus milk. Behav Pharmacol. 2013 Sep; 24(5-6):486-95. PMID: 23903243.
    Citations: 2     Fields:    Translation:Animals
  15. Thakur GA, Bajaj S, Paronis C, Peng Y, Bowman AL, Barak LS, Caron MG, Parrish D, Deschamps JR, Makriyannis A. Novel adamantyl cannabinoids as CB1 receptor probes. J Med Chem. 2013 May 23; 56(10):3904-21. PMID: 23621789.
    Citations: 13     Fields:    Translation:Animals
  16. Paronis CA, Nikas SP, Shukla VG, Makriyannis A. ?(9)-Tetrahydrocannabinol acts as a partial agonist/antagonist in mice. Behav Pharmacol. 2012 Dec; 23(8):802-5. PMID: 23075707.
    Citations: 27     Fields:    Translation:Animals
  17. Paronis CA, Thakur GA, Bajaj S, Nikas SP, Vemuri VK, Makriyannis A, Bergman J. Diuretic effects of cannabinoids. J Pharmacol Exp Ther. 2013 Jan; 344(1):8-14. PMID: 23019138.
    Citations: 13     Fields:    Translation:Animals
  18. Paronis CA, Bergman J. Buprenorphine and opioid antagonism, tolerance, and naltrexone-precipitated withdrawal. J Pharmacol Exp Ther. 2011 Feb; 336(2):488-95. PMID: 21051498.
    Citations: 14     Fields:    Translation:Animals
  19. Nikas SP, Alapafuja SO, Papanastasiou I, Paronis CA, Shukla VG, Papahatjis DP, Bowman AL, Halikhedkar A, Han X, Makriyannis A. Novel 1',1'-chain substituted hexahydrocannabinols: 9ß-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist. J Med Chem. 2010 Oct 14; 53(19):6996-7010. PMID: 20925434.
    Citations: 24     Fields:    Translation:AnimalsCells
  20. Desai RI, Paronis CA, Martin J, Desai R, Bergman J. Monoaminergic psychomotor stimulants: discriminative stimulus effects and dopamine efflux. J Pharmacol Exp Ther. 2010 Jun; 333(3):834-43. PMID: 20190012.
    Citations: 24     Fields:    Translation:AnimalsCells
  21. Desai RI, Neumeyer JL, Bergman J, Paronis CA. Pharmacological characterization of the effects of dopamine D(1) agonists on eye blinking in rats. Behav Pharmacol. 2007 Dec; 18(8):745-54. PMID: 17989512.
    Citations: 6     Fields:    Translation:Animals
  22. Bergman J, Delatte MS, Paronis CA, Vemuri K, Thakur GA, Makriyannis A. Some effects of CB1 antagonists with inverse agonist and neutral biochemical properties. Physiol Behav. 2008 Mar 18; 93(4-5):666-70. PMID: 18076956.
    Citations: 33     Fields:    Translation:Animals
  23. Delatte MS, Paronis CA. Evaluation of cannabinoid agonists using punished responding and midazolam discrimination procedures in squirrel monkeys. Psychopharmacology (Berl). 2008 Jul; 198(4):521-8. PMID: 17882403.
    Citations: 2     Fields:    Translation:Animals
  24. Desai RI, Neumeyer JL, Paronis CA, Nguyen P, Bergman J. Behavioral effects of the R-(+)- and S-(-)-enantiomers of the dopamine D(1)-like partial receptor agonist SKF 83959 in monkeys. Eur J Pharmacol. 2007 Mar 08; 558(1-3):98-106. PMID: 17207791.
    Citations: 3     Fields:    Translation:Animals
  25. Bergman J, Paronis CA. Measuring the reinforcing strength of abused drugs. Mol Interv. 2006 Oct; 6(5):273-83. PMID: 17035668.
    Citations: 13     Fields:    Translation:HumansAnimals
  26. Paronis CA. Modulating GABA modulators. Br J Pharmacol. 2006 Feb; 147(3):237-8. PMID: 16331288.
    Citations: 2     Fields:    Translation:HumansAnimals
  27. Gasior M, Bergman J, Kallman MJ, Paronis CA. Evaluation of the reinforcing effects of monoamine reuptake inhibitors under a concurrent schedule of food and i.v. drug delivery in rhesus monkeys. Neuropsychopharmacology. 2005 Apr; 30(4):758-64. PMID: 15526000.
    Citations: 13     Fields:    Translation:Animals
  28. Gasior M, Paronis CA, Bergman J. Modification by dopaminergic drugs of choice behavior under concurrent schedules of intravenous saline and food delivery in monkeys. J Pharmacol Exp Ther. 2004 Jan; 308(1):249-59. PMID: 14563783.
    Citations: 14     Fields:    Translation:Animals
  29. Yasar S, Bergman J, Munzar P, Redhi G, Tober C, Knebel N, Zschiesche M, Paronis C. Evaluation of the novel antiepileptic drug, AWD 131-138, for benzodiazepine-like discriminative stimulus and reinforcing effects in squirrel monkeys. Eur J Pharmacol. 2003 Apr 04; 465(3):257-65. PMID: 12681437.
    Citations: 1     Fields:    Translation:Animals
  30. Hudzik TJ, Yanek M, Porrey T, Evenden J, Paronis C, Mastrangelo M, Ryan C, Ross S, Stenfors C. Behavioral pharmacology of AR-A000002, a novel, selective 5-hydroxytryptamine(1B) antagonist. J Pharmacol Exp Ther. 2003 Mar; 304(3):1072-84. PMID: 12604684.
    Citations: 12     Fields:    Translation:Animals
  31. Kassel JD, Stroud LR, Paronis CA. Smoking, stress, and negative affect: correlation, causation, and context across stages of smoking. Psychol Bull. 2003 Mar; 129(2):270-304. PMID: 12696841.
    Citations: 384     Fields:    Translation:HumansAnimals
  32. Paronis CA, Gasior M, Bergman J. Effects of cocaine under concurrent fixed ratio schedules of food and IV drug availability: a novel choice procedure in monkeys. Psychopharmacology (Berl). 2002 Oct; 163(3-4):283-91. PMID: 12373429.
    Citations: 17     Fields:    Translation:Animals
  33. Paronis CA, Cox ED, Cook JM, Bergman J. Different types of GABA(A) receptors may mediate the anticonflict and response rate-decreasing effects of zaleplon, zolpidem, and midazolam in squirrel monkeys. Psychopharmacology (Berl). 2001 Aug; 156(4):461-8. PMID: 11498724.
    Citations: 7     Fields:    Translation:Animals
  34. Kishioka S, Paronis CA, Woods JH. Acute dependence on, but not tolerance to, heroin and morphine as measured by respiratory effects in rhesus monkeys. Eur J Pharmacol. 2000 Jun 09; 398(1):121-30. PMID: 10856456.
    Citations: 8     Fields:    Translation:Animals
  35. Kishioka S, Paronis CA, Lewis JW, Woods JH. Buprenorphine and methoclocinnamox: agonist and antagonist effects on respiratory function in rhesus monkeys. Eur J Pharmacol. 2000 Mar 17; 391(3):289-97. PMID: 10729371.
    Citations: 10     Fields:    Translation:Animals
  36. Paronis CA, Bergman J. Apparent pA2 values of benzodiazepine antagonists and partial agonists in monkeys. J Pharmacol Exp Ther. 1999 Sep; 290(3):1222-9. PMID: 10454498.
    Citations: 17     Fields:    Translation:AnimalsCells
  37. Paronis CA, Woods JH. Clocinnamox dose-dependently antagonizes morphine-analgesia and [3H]DAMGO binding in rats. Eur J Pharmacol. 1997 Oct 15; 337(1):27-34. PMID: 9389377.
    Citations: 4     Fields:    Translation:Animals
  38. Paronis CA, Woods JH. Ventilation in morphine-maintained rhesus monkeys. I: Effects of naltrexone and abstinence-associated withdrawal. J Pharmacol Exp Ther. 1997 Jul; 282(1):348-54. PMID: 9223573.
    Citations: 3     Fields:    Translation:Animals
  39. Paronis CA, Woods JH. Ventilation in morphine-maintained rhesus monkeys. II: Tolerance to the antinociceptive but not the ventilatory effects of morphine. J Pharmacol Exp Ther. 1997 Jul; 282(1):355-62. PMID: 9223574.
    Citations: 8     Fields:    Translation:Animals
  40. Paronis CA, Holtzman SG. Sensitization and tolerance to the discriminative stimulus effects of mu-opioid agonists. Psychopharmacology (Berl). 1994 May; 114(4):601-10. PMID: 7855222.
    Citations: 3     Fields:    Translation:Animals
  41. Paronis CA, Waddell AB, Holtzman SG. Naltrexone in vivo protects mu receptors from inactivation by beta-funaltrexamine, but not kappa receptors from inactivation by nor-binaltorphimine. Pharmacol Biochem Behav. 1993 Dec; 46(4):813-7. PMID: 8309960.
    Citations: 3     Fields:    Translation:Animals
  42. Paronis CA, Holtzman SG. Development of tolerance to the analgesic activity of mu agonists after continuous infusion of morphine, meperidine or fentanyl in rats. J Pharmacol Exp Ther. 1992 Jul; 262(1):1-9. PMID: 1625189.
    Citations: 38     Fields:    Translation:Animals
  43. Paronis CA, Holtzman SG. Apparent pA2 value of naltrexone is not changed in rats following continuous exposure to morphine or naloxone. Life Sci. 1992; 50(19):1407-16. PMID: 1573974.
    Citations:    Fields:    Translation:Animals
  44. Paronis CA, Holtzman SG. Increased analgesic potency of mu agonists after continuous naloxone infusion in rats. J Pharmacol Exp Ther. 1991 Nov; 259(2):582-9. PMID: 1658305.
    Citations: 14     Fields:    Translation:Animals
  45. Adams JU, Paronis CA, Holtzman SG. Assessment of relative intrinsic activity of mu-opioid analgesics in vivo by using beta-funaltrexamine. J Pharmacol Exp Ther. 1990 Dec; 255(3):1027-32. PMID: 2175793.
    Citations: 30     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.