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David E Cohen, M.D.,Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. T32DK116970 (COHEN, DAVID E.) May 1, 2019 - Apr 30, 2024
    Multidisciplinary Research Training in Gastroenterology and Hepatology
    Role: Principal Investigator
  2. R01DK103046 (COHEN, DAVID E.) Jul 5, 2015 - Jun 30, 2024
    Them1-Mediated Metabolic Regulation and Pathogenic Role in NAFLD
    Role: Principal Investigator
  3. R24DK091211 (ENGELHARDT, JOHN F) Jul 20, 2011 - Jun 30, 2013
    Etiology of Cystic Fibrosis-Related Diabetes in a CFTR-knockout Ferret
    Role: Co-Principal Investigator
  4. R01DK056626 (COHEN, DAVID E.) Dec 1, 1999 - Mar 31, 2025
    Phospholipid-Mediated Metabolic Control in the Pathogenesis of NAFLD
    Role: Principal Investigator
  5. P30DK034854 (LENCER, WAYNE I) Sep 1, 1997 - Mar 31, 2026
    Integrated Epithelial and Muscosal Biology
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ghany MG, Lok ASF, Dienstag JL, Feinstone SM, Hoofnagle JH, Jake Liang T, Seeff LB, Cohen DE, Bezerra JA, Chung RT. The 2020 Nobel Prize for Medicine or Physiology for the Discovery of Hepatitis C Virus: A Triumph of Curiosity and Persistence. Hepatology. 2021 Nov; 74(5):2813-2823. PMID: 33784424.
    Citations:    Fields:    
  2. Imai N, Nicholls HT, Alves-Bezerra M, Li Y, Ivanova AA, Ortlund EA, Cohen DE. Upregulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance. Hepatology. 2021 Aug 25. PMID: 34433228.
    Citations:    Fields:    
  3. Li Y, Imai N, Nicholls HT, Roberts BR, Goyal S, Krisko TI, Ang LH, Tillman MC, Roberts AM, Baqai M, Ortlund EA, Cohen DE, Hagen SJ. Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice. Nat Commun. 2021 06 09; 12(1):3493. PMID: 34108467.
    Citations:    Fields:    Translation:AnimalsCells
  4. Krumm CS, Xu X, Bare CJ, Holman CD, Kersten S, Dow LE, Lee AH, Cohen DE. Inducible hepatic expression of CREBH mitigates diet-induced obesity, insulin resistance, and hepatic steatosis in mice. J Biol Chem. 2021 07; 297(1):100815. PMID: 34023388.
    Citations:    Fields:    Translation:Animals
  5. Bissig-Choisat B, Alves-Bezerra M, Zorman B, Ochsner SA, Barzi M, Legras X, Yang D, Borowiak M, Dean AM, York RB, Galvan NTN, Goss J, Lagor WR, Moore DD, Cohen DE, McKenna NJ, Sumazin P, Bissig KD. A human liver chimeric mouse model for non-alcoholic fatty liver disease. JHEP Rep. 2021 Jun; 3(3):100281. PMID: 34036256.
    Citations: 1     
  6. Hajifathalian K, Sharaiha RZ, Kumar S, Krisko T, Skaf D, Ang B, Redd WD, Zhou JC, Hathorn KE, McCarty TR, Bazarbashi AN, Njie C, Wong D, Shen L, Sholle E, Cohen DE, Brown RS, Chan WW, Fortune BE. Development and external validation of a prediction risk model for short-term mortality among hospitalized U.S. COVID-19 patients: A proposal for the COVID-AID risk tool. PLoS One. 2020; 15(9):e0239536. PMID: 32997700.
    Citations: 10     Fields:    Translation:HumansCellsPHPublic Health
  7. Tillman MC, Imai N, Li Y, Khadka M, Okafor CD, Juneja P, Adhiyaman A, Hagen SJ, Cohen DE, Ortlund EA. Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine. Proc Natl Acad Sci U S A. 2020 09 08; 117(36):22080-22089. PMID: 32820071.
    Citations: 1     Fields:    Translation:HumansCells
  8. Hajifathalian K, Mahadev S, Schwartz RE, Shah S, Sampath K, Schnoll-Sussman F, Brown RS, Carr-Locke D, Cohen DE, Sharaiha RZ. SARS-COV-2 infection (coronavirus disease 2019) for the gastrointestinal consultant. World J Gastroenterol. 2020 Apr 14; 26(14):1546-1553. PMID: 32327904.
    Citations: 17     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  9. Walker RG, Barrandon O, Poggioli T, Dagdeviren S, Carroll SH, Mills MJ, Mendello KR, Gomez Y, Loffredo FS, Pancoast JR, Macias-Trevino C, Marts C, LeClair KB, Noh HL, Kim T, Banks AS, Kim JK, Cohen DE, Wagers AJ, Melton DA, Lee RT. Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice. Sci Rep. 2020 03 12; 10(1):4561. PMID: 32165710.
    Citations: 3     Fields:    Translation:AnimalsCells
  10. Krisko TI, Nicholls HT, Bare CJ, Holman CD, Putzel GG, Jansen RS, Sun N, Rhee KY, Banks AS, Cohen DE. Dissociation of Adaptive Thermogenesis from Glucose Homeostasis in Microbiome-Deficient Mice. Cell Metab. 2020 03 03; 31(3):592-604.e9. PMID: 32084379.
    Citations: 15     Fields:    Translation:AnimalsCells
  11. Softic S, Meyer JG, Wang GX, Gupta MK, Batista TM, Lauritzen HPMM, Fujisaka S, Serra D, Herrero L, Willoughby J, Fitzgerald K, Ilkayeva O, Newgard CB, Gibson BW, Schilling B, Cohen DE, Kahn CR. Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins. Cell Metab. 2019 10 01; 30(4):735-753.e4. PMID: 31577934.
    Citations: 30     Fields:    Translation:AnimalsCells
  12. Pockros PJ, Fuchs M, Freilich B, Schiff E, Kohli A, Lawitz EJ, Hellstern PA, Owens-Grillo J, Van Biene C, Shringarpure R, MacConell L, Shapiro D, Cohen DE. CONTROL: A randomized phase 2 study of obeticholic acid and atorvastatin on lipoproteins in nonalcoholic steatohepatitis patients. Liver Int. 2019 11; 39(11):2082-2093. PMID: 31402538.
    Citations: 14     Fields:    Translation:HumansCTClinical Trials
  13. Sinden DS, Holman CD, Bare CJ, Sun X, Gade AR, Cohen DE, Pitt GS. Knockout of the X-linked Fgf13 in the hypothalamic paraventricular nucleus impairs sympathetic output to brown fat and causes obesity. FASEB J. 2019 10; 33(10):11579-11594. PMID: 31339804.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Alves-Bezerra M, Li Y, Acuña M, Ivanova AA, Corey KE, Ortlund EA, Cohen DE. Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids Into Triglyceride Biosynthesis. Hepatology. 2019 08; 70(2):496-510. PMID: 30516845.
    Citations: 5     Fields:    Translation:HumansAnimals
  15. Chaturantabut S, Shwartz A, Evason KJ, Cox AG, Labella K, Schepers AG, Yang S, Acuña M, Houvras Y, Mancio-Silva L, Romano S, Gorelick DA, Cohen DE, Zon LI, Bhatia SN, North TE, Goessling W. Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 2019 05; 156(6):1788-1804.e13. PMID: 30641053.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  16. Tillander V, Miniami A, Alves-Bezerra M, Coleman RA, Cohen DE. Thioesterase superfamily member 2 promotes hepatic insulin resistance in the setting of glycerol-3-phosphate acyltransferase 1-induced steatosis. J Biol Chem. 2019 02 08; 294(6):2009-2020. PMID: 30523156.
    Citations: 3     Fields:    Translation:AnimalsCells
  17. Xu X, Krumm C, So JS, Bare CJ, Holman C, Gromada J, Cohen DE, Lee AH. Preemptive Activation of the Integrated Stress Response Protects Mice From Diet-Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction. Hepatology. 2018 12; 68(6):2167-2181. PMID: 29698569.
    Citations: 10     Fields:    Translation:AnimalsCells
  18. Mina AI, LeClair RA, LeClair KB, Cohen DE, Lantier L, Banks AS. CalR: A Web-Based Analysis Tool for Indirect Calorimetry Experiments. Cell Metab. 2018 10 02; 28(4):656-666.e1. PMID: 30017358.
    Citations: 42     Fields:    Translation:HumansAnimals
  19. Softic S, Gupta MK, Wang GX, Fujisaka S, O'Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR. Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. J Clin Invest. 2018 03 01; 128(3):1199. PMID: 29493547.
    Citations: 6     Fields:    
  20. Ji YX, Huang Z, Yang X, Wang X, Zhao LP, Wang PX, Zhang XJ, Alves-Bezerra M, Cai L, Zhang P, Lu YX, Bai L, Gao MM, Zhao H, Tian S, Wang Y, Huang ZX, Zhu XY, Zhang Y, Gong J, She ZG, Li F, Cohen DE, Li H. The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis. Nat Med. 2018 02; 24(2):213-223. PMID: 29291351.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  21. Alves-Bezerra M, Cohen DE. Triglyceride Metabolism in the Liver. Compr Physiol. 2017 12 12; 8(1):1-8. PMID: 29357123.
    Citations: 94     Fields:    Translation:HumansCells
  22. Desai A, Alves-Bezerra M, Li Y, Ozdemir C, Bare CJ, Li Y, Hagen SJ, Cohen DE. Regulation of fatty acid trafficking in liver by thioesterase superfamily member 1. J Lipid Res. 2018 02; 59(2):368-379. PMID: 29208699.
    Citations:    Fields:    Translation:Animals
  23. Ersoy BA, Maner-Smith KM, Li Y, Alpertunga I, Cohen DE. Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress. J Clin Invest. 2018 01 02; 128(1):141-156. PMID: 29202465.
    Citations: 9     Fields:    Translation:AnimalsCells
  24. Softic S, Gupta MK, Wang GX, Fujisaka S, O'Neill BT, Rao TN, Willoughby J, Harbison C, Fitzgerald K, Ilkayeva O, Newgard CB, Cohen DE, Kahn CR. Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. J Clin Invest. 2017 Nov 01; 127(11):4059-4074. PMID: 28972537.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  25. Ma H, Sales VM, Wolf AR, Subramanian S, Matthews TJ, Chen M, Sharma A, Gall W, Kulik W, Cohen DE, Adachi Y, Griffin NW, Gordon JI, Patti ME, Isganaitis E. Attenuated Effects of Bile Acids on Glucose Metabolism and Insulin Sensitivity in a Male Mouse Model of Prenatal Undernutrition. Endocrinology. 2017 08 01; 158(8):2441-2452. PMID: 28637315.
    Citations: 2     Fields:    Translation:Animals
  26. Palmer CJ, Bruckner RJ, Paulo JA, Kazak L, Long JZ, Mina AI, Deng Z, LeClair KB, Hall JA, Hong S, Zushin PH, Smith KL, Gygi SP, Hagen S, Cohen DE, Banks AS. Cdkal1, a type 2 diabetes susceptibility gene, regulates mitochondrial function in adipose tissue. Mol Metab. 2017 10; 6(10):1212-1225. PMID: 29031721.
    Citations: 8     Fields:    Translation:AnimalsCells
  27. Carroll SH, Zhang E, Wang BF, LeClair KB, Rahman A, Cohen DE, Plutzky J, Patwari P, Lee RT. Correction: Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in ß-adrenergic receptor signaling. PLoS One. 2017; 12(7):e0181492. PMID: 28700749.
    Citations: 1     Fields:    
  28. Nicholls HT, Hornick JL, Cohen DE. Phosphatidylcholine transfer protein/StarD2 promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2017 Jul 01; 313(1):G50-G61. PMID: 28385694.
    Citations: 5     Fields:    Translation:Animals
  29. Tillander V, Alexson SEH, Cohen DE. Deactivating Fatty Acids: Acyl-CoA Thioesterase-Mediated Control of Lipid Metabolism. Trends Endocrinol Metab. 2017 07; 28(7):473-484. PMID: 28385385.
    Citations: 29     Fields:    Translation:HumansAnimals
  30. Carroll SH, Zhang E, Wang BF, LeClair KB, Rahman A, Cohen DE, Plutzky J, Patwari P, Lee RT. Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in ß-adrenergic receptor signaling. PLoS One. 2017; 12(3):e0173823. PMID: 28291835.
    Citations: 5     Fields:    Translation:AnimalsCells
  31. O'Donnell-Luria AH, Lin AP, Merugumala SK, Rohr F, Waisbren SE, Lynch R, Tchekmedyian V, Goldberg AD, Bellinger A, McFaline-Figueroa JR, Simon T, Gershanik EF, Levy BD, Cohen DE, Samuels MA, Berry GT, Frank NY. Brain MRS glutamine as a biomarker to guide therapy of hyperammonemic coma. Mol Genet Metab. 2017 05; 121(1):9-15. PMID: 28408159.
    Citations: 3     Fields:    Translation:Humans
  32. Cohen DE. Of TICE in Men. Cell Metab. 2016 12 13; 24(6):773-774. PMID: 27974175.
    Citations: 1     Fields:    Translation:Humans
  33. Krisko TI, LeClair KB, Cohen DE. Genetic ablation of phosphatidylcholine transfer protein/StarD2 in ob/ob mice improves glucose tolerance without increasing energy expenditure. Metabolism. 2017 03; 68:145-149. PMID: 28183446.
    Citations: 1     Fields:    Translation:Animals
  34. Lynch L, Hogan AE, Duquette D, Lester C, Banks A, LeClair K, Cohen DE, Ghosh A, Lu B, Corrigan M, Stevanovic D, Maratos-Flier E, Drucker DJ, O'Shea D, Brenner M. iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy. Cell Metab. 2016 09 13; 24(3):510-519. PMID: 27593966.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  35. Cox AG, Hwang KL, Brown KK, Evason K, Beltz S, Tsomides A, O'Connor K, Galli GG, Yimlamai D, Chhangawala S, Yuan M, Lien EC, Wucherpfennig J, Nissim S, Minami A, Cohen DE, Camargo FD, Asara JM, Houvras Y, Stainier DYR, Goessling W. Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nat Cell Biol. 2016 08; 18(8):886-896. PMID: 27428308.
    Citations: 64     Fields:    Translation:HumansAnimals
  36. Omary MB, Cohen DE, El-Omar EM, Jalan R, Low MJ, Nathanson MH, Peek RM, Turner JR. Not all mice are the same: Standardization of animal research data presentation. Hepatology. 2016 06; 63(6):1752-4. PMID: 27205897.
    Citations: 4     Fields:    Translation:Animals
  37. Harada PH, Cook NR, Cohen DE, Paynter NP, Rose L, Ridker PM. Relation of Alanine Aminotransferase Levels to Cardiovascular Events and Statin Efficacy. Am J Cardiol. 2016 Jul 01; 118(1):49-55. PMID: 27317931.
    Citations: 1     Fields:    Translation:Humans
  38. Okada K, LeClair KB, Zhang Y, Li Y, Ozdemir C, Krisko TI, Hagen SJ, Betensky RA, Banks AS, Cohen DE. Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue. Mol Metab. 2016 May; 5(5):340-351. PMID: 27110486.
    Citations: 19     Fields:    
  39. Softic S, Cohen DE, Kahn CR. Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease. Dig Dis Sci. 2016 May; 61(5):1282-93. PMID: 26856717.
    Citations: 136     Fields:    Translation:HumansCells
  40. Bays H, Kothari SN, Azagury DE, Morton JM, Nguyen NT, Jones PH, Jacobson TA, Cohen DE, Orringer C, Westman EC, Horn DB, Scinta W, Primack C. Lipids and bariatric procedures Part 2 of 2: scientific statement from the American Society for Metabolic and Bariatric Surgery (ASMBS), the National Lipid Association (NLA), and Obesity Medicine Association (OMA). Surg Obes Relat Dis. 2016 Mar-Apr; 12(3):468-495. PMID: 27050404.
    Citations: 12     Fields:    Translation:Humans
  41. Bays HE, Jones PH, Jacobson TA, Cohen DE, Orringer CE, Kothari S, Azagury DE, Morton J, Nguyen NT, Westman EC, Horn DB, Scinta W, Primack C. Lipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: FULL REPORT. J Clin Lipidol. 2016 Jan-Feb; 10(1):33-57. PMID: 26892120.
    Citations: 5     Fields:    Translation:HumansAnimals
  42. Bays HE, Jones PH, Jacobson TA, Cohen DE, Orringer CE, Kothari S, Azagury DE, Morton J, Nguyen NT, Westman EC, Horn DB, Scinta W, Primack C. Lipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association, American Society for Metabolic and Bariatric Surgery, and Obesity Medicine Association: EXECUTIVE SUMMARY. J Clin Lipidol. 2016 Jan-Feb; 10(1):15-32. PMID: 26892119.
    Citations: 1     Fields:    Translation:HumansAnimals
  43. Wagschal A, Najafi-Shoushtari SH, Wang L, Goedeke L, Sinha S, deLemos AS, Black JC, Ramírez CM, Li Y, Tewhey R, Hatoum I, Shah N, Lu Y, Kristo F, Psychogios N, Vrbanac V, Lu YC, Hla T, de Cabo R, Tsang JS, Schadt E, Sabeti PC, Kathiresan S, Cohen DE, Whetstine J, Chung RT, Fernández-Hernando C, Kaplan LM, Bernards A, Gerszten RE, Näär AM. Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis. Nat Med. 2015 Nov; 21(11):1290-7. PMID: 26501192.
    Citations: 83     Fields:    Translation:HumansAnimals
  44. Nayeb-Hashemi H, Desai A, Demchev V, Bronson RT, Hornick JL, Cohen DE, Ukomadu C. Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development. Biochem Biophys Res Commun. 2015 Sep 18; 465(2):167-73. PMID: 26225745.
    Citations: 8     Fields:    Translation:AnimalsCells
  45. Yildiz HM, Speciner L, Ozdemir C, Cohen DE, Carrier RL. Food-associated stimuli enhance barrier properties of gastrointestinal mucus. Biomaterials. 2015 Jun; 54:1-8. PMID: 25907034.
    Citations: 9     Fields:    Translation:Animals
  46. Price A, Ramachandran S, Smith GP, Stevenson ML, Pomeranz MK, Cohen DE. Oral allergy syndrome (pollen-food allergy syndrome). Dermatitis. 2015 Mar-Apr; 26(2):78-88. PMID: 25757079.
    Citations: 19     Fields:    Translation:HumansAnimalsPHPublic Health
  47. Hashemi N, Odze RD, McGowan MP, Santos RD, Stroes ESG, Cohen DE. Liver histology during Mipomersen therapy for severe hypercholesterolemia. J Clin Lipidol. 2014 Nov-Dec; 8(6):606-611. PMID: 25499943.
    Citations: 7     Fields:    Translation:Humans
  48. Rocha VZ, Folco EJ, Ozdemir C, Sheikine Y, Christen T, Sukhova GK, Tang EH, Bittencourt MS, Santos RD, Luster AD, Cohen DE, Libby P. CXCR3 controls T-cell accumulation in fat inflammation. Arterioscler Thromb Vasc Biol. 2014 Jul; 34(7):1374-81. PMID: 24812325.
    Citations: 16     Fields:    Translation:AnimalsCells
  49. Bays H, Cohen DE, Chalasani N, Harrison SA. An assessment by the Statin Liver Safety Task Force: 2014 update. J Clin Lipidol. 2014 May-Jun; 8(3 Suppl):S47-57. PMID: 24793441.
    Citations: 45     Fields:    Translation:Humans
  50. Kawano Y, Ersoy BA, Li Y, Nishiumi S, Yoshida M, Cohen DE. Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization. Mol Cell Biol. 2014 Jul; 34(13):2396-408. PMID: 24732803.
    Citations: 12     Fields:    Translation:AnimalsCells
  51. Astapova I, Ramadoss P, Costa-e-Sousa RH, Ye F, Holtz KA, Li Y, Niepel MW, Cohen DE, Hollenberg AN. Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRß1-governed pathway. J Clin Invest. 2014 May; 124(5):1976-86. PMID: 24713658.
    Citations: 12     Fields:    Translation:Animals
  52. Cohen DE. Lipids and the liver. Semin Liver Dis. 2013 Nov; 33(4):299-300. PMID: 24222087.
    Citations:    Fields:    Translation:HumansAnimals
  53. Cohen DE, Fisher EA. Lipoprotein metabolism, dyslipidemia, and nonalcoholic fatty liver disease. Semin Liver Dis. 2013 Nov; 33(4):380-8. PMID: 24222095.
    Citations: 49     Fields:    Translation:HumansAnimals
  54. Edelstein LC, Simon LM, Montoya RT, Holinstat M, Chen ES, Bergeron A, Kong X, Nagalla S, Mohandas N, Cohen DE, Dong JF, Shaw C, Bray PF. Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c. Nat Med. 2013 Dec; 19(12):1609-16. PMID: 24216752.
    Citations: 84     Fields:    Translation:HumansCells
  55. Kang HW, Ozdemir C, Kawano Y, LeClair KB, Vernochet C, Kahn CR, Hagen SJ, Cohen DE. Thioesterase superfamily member 2/Acyl-CoA thioesterase 13 (Them2/Acot13) regulates adaptive thermogenesis in mice. J Biol Chem. 2013 Nov 15; 288(46):33376-86. PMID: 24072708.
    Citations: 15     Fields:    Translation:AnimalsCells
  56. Ersoy BA, Tarun A, D'Aquino K, Hancer NJ, Ukomadu C, White MF, Michel T, Manning BD, Cohen DE. Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. Sci Signal. 2013 Jul 30; 6(286):ra64. PMID: 23901139.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  57. Demchev V, Malana G, Vangala D, Stoll J, Desai A, Kang HW, Li Y, Nayeb-Hashemi H, Niepel M, Cohen DE, Ukomadu C. Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization. PLoS One. 2013; 8(3):e58084. PMID: 23483972.
    Citations: 17     Fields:    Translation:Animals
  58. Kawano Y, Cohen DE. Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease. J Gastroenterol. 2013 Apr; 48(4):434-41. PMID: 23397118.
    Citations: 219     Fields:    Translation:HumansCells
  59. Cohen DE. New players on the metabolic stage: How do you like Them Acots? Adipocyte. 2013 Jan 01; 2(1):3-6. PMID: 23700546.
    Citations: 15     Fields:    
  60. Han S, Cohen DE. Functional characterization of thioesterase superfamily member 1/Acyl-CoA thioesterase 11: implications for metabolic regulation. J Lipid Res. 2012 Dec; 53(12):2620-31. PMID: 22993230.
    Citations: 14     Fields:    Translation:Animals
  61. Kiefer FW, Vernochet C, O'Brien P, Spoerl S, Brown JD, Nallamshetty S, Zeyda M, Stulnig TM, Cohen DE, Kahn CR, Plutzky J. Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Nat Med. 2012 Jun; 18(6):918-25. PMID: 22561685.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  62. Zhang Y, Li Y, Niepel MW, Kawano Y, Han S, Liu S, Marsili A, Larsen PR, Lee CH, Cohen DE. Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance. Proc Natl Acad Sci U S A. 2012 Apr 03; 109(14):5417-22. PMID: 22427358.
    Citations: 46     Fields:    Translation:AnimalsCells
  63. Kang HW, Niepel MW, Han S, Kawano Y, Cohen DE. Thioesterase superfamily member 2/acyl-CoA thioesterase 13 (Them2/Acot13) regulates hepatic lipid and glucose metabolism. FASEB J. 2012 May; 26(5):2209-21. PMID: 22345407.
    Citations: 32     Fields:    Translation:AnimalsCells
  64. Patwari P, Emilsson V, Schadt EE, Chutkow WA, Lee S, Marsili A, Zhang Y, Dobrin R, Cohen DE, Larsen PR, Zavacki AM, Fong LG, Young SG, Lee RT. The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell Metab. 2011 Nov 02; 14(5):671-83. PMID: 21982743.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  65. Shishova EY, Stoll JM, Ersoy BA, Shrestha S, Scapa EF, Li Y, Niepel MW, Su Y, Jelicks LA, Stahl GL, Glicksman MA, Gutierrez-Juarez R, Cuny GD, Cohen DE. Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production. Hepatology. 2011 Aug; 54(2):664-74. PMID: 21538437.
    Citations: 12     Fields:    Translation:Animals
  66. Castillo M, Hall JA, Correa-Medina M, Ueta C, Kang HW, Cohen DE, Bianco AC. Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality. Diabetes. 2011 Apr; 60(4):1082-9. PMID: 21335378.
    Citations: 68     Fields:    Translation:Animals
  67. Tong F, Billheimer J, Shechtman CF, Liu Y, Crooke R, Graham M, Cohen DE, Sturley SL, Rader DJ. Decreased expression of ARV1 results in cholesterol retention in the endoplasmic reticulum and abnormal bile acid metabolism. J Biol Chem. 2010 Oct 29; 285(44):33632-41. PMID: 20663892.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  68. Rigotti A, Cohen DE, Zanlungo S. STARTing to understand MLN64 function in cholesterol transport. J Lipid Res. 2010 Aug; 51(8):2015-7. PMID: 20511492.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  69. Najafi-Shoushtari SH, Kristo F, Li Y, Shioda T, Cohen DE, Gerszten RE, Näär AM. MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science. 2010 Jun 18; 328(5985):1566-9. PMID: 20466882.
    Citations: 391     Fields:    Translation:HumansAnimalsCells
  70. Taddei TH, Dziura J, Chen S, Yang R, Hyogo H, Sullards C, Cohen DE, Pastores G, Mistry PK. High incidence of cholesterol gallstone disease in type 1 Gaucher disease: characterizing the biliary phenotype of type 1 Gaucher disease. J Inherit Metab Dis. 2010 Jun; 33(3):291-300. PMID: 20354791.
    Citations: 17     Fields:    Translation:HumansCells
  71. Kang HW, Wei J, Cohen DE. PC-TP/StARD2: Of membranes and metabolism. Trends Endocrinol Metab. 2010 Jul; 21(7):449-56. PMID: 20338778.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  72. Kang HW, Kanno K, Scapa EF, Cohen DE. Regulatory role for phosphatidylcholine transfer protein/StarD2 in the metabolic response to peroxisome proliferator activated receptor alpha (PPARalpha). Biochim Biophys Acta. 2010 Apr; 1801(4):496-502. PMID: 20045742.
    Citations: 12     Fields:    Translation:Animals
  73. Wei J, Kang HW, Cohen DE. Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs. Biochem J. 2009 Jun 26; 421(2):311-22. PMID: 19405909.
    Citations: 31     Fields:    Translation:AnimalsCells
  74. Kang HW, Ribich S, Kim BW, Hagen SJ, Bianco AC, Cohen DE. Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue. J Lipid Res. 2009 Nov; 50(11):2212-21. PMID: 19502644.
    Citations: 15     Fields:    Translation:AnimalsCells
  75. Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM. Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression. Diabetes. 2009 Jul; 58(7):1499-508. PMID: 19366863.
    Citations: 60     Fields:    Translation:AnimalsCells
  76. Wang DQ, Cohen DE, Carey MC. Biliary lipids and cholesterol gallstone disease. J Lipid Res. 2009 Apr; 50 Suppl:S406-11. PMID: 19017613.
    Citations: 60     Fields:    Translation:HumansAnimals
  77. Wagle N, Xian J, Shishova EY, Wei J, Glicksman MA, Cuny GD, Stein RL, Cohen DE. Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Anal Biochem. 2008 Dec 01; 383(1):85-92. PMID: 18762160.
    Citations: 7     Fields:    Translation:HumansAnimals
  78. Lee AH, Scapa EF, Cohen DE, Glimcher LH. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science. 2008 Jun 13; 320(5882):1492-6. PMID: 18556558.
    Citations: 405     Fields:    Translation:AnimalsCells
  79. Cohen DE. Balancing cholesterol synthesis and absorption in the gastrointestinal tract. J Clin Lipidol. 2008 Apr; 2(2):S1-3. PMID: 19343078.
    Citations: 24     Fields:    
  80. Scapa EF, Pocai A, Wu MK, Gutierrez-Juarez R, Glenz L, Kanno K, Li H, Biddinger S, Jelicks LA, Rossetti L, Cohen DE. Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2. FASEB J. 2008 Jul; 22(7):2579-90. PMID: 18347010.
    Citations: 21     Fields:    Translation:AnimalsCells
  81. Wooton-Kee CR, Cohen DE, Vore M. Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G1009-16. PMID: 18292185.
    Citations: 8     Fields:    Translation:Animals
  82. Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Haas JT, Alemán JO, Suzuki R, Scapa EF, Agarwal C, Carey MC, Stephanopoulos G, Cohen DE, King GL, Ginsberg HN, Kahn CR. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab. 2008 Feb; 7(2):125-34. PMID: 18249172.
    Citations: 200     Fields:    Translation:Animals
  83. Van Dyck F, Braem CV, Chen Z, Declercq J, Deckers R, Kim BM, Ito S, Wu MK, Cohen DE, Dewerchin M, Derua R, Waelkens E, Fiette L, Roebroek A, Schuit F, Van de Ven WJ, Shivdasani RA. Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons. Cell Metab. 2007 Nov; 6(5):406-13. PMID: 17983586.
    Citations: 20     Fields:    Translation:AnimalsCells
  84. Kanno K, Wu MK, Agate DS, Fanelli BJ, Wagle N, Scapa EF, Ukomadu C, Cohen DE. Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2. J Biol Chem. 2007 Oct 19; 282(42):30728-36. PMID: 17704541.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  85. Bays HE, Cohen DE. Rationale and design of a prospective clinical trial program to evaluate the glucose-lowering effects of colesevelam HCl in patients with type 2 diabetes mellitus. Curr Med Res Opin. 2007 Jul; 23(7):1673-84. PMID: 17588297.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  86. Kanno K, Wu MK, Scapa EF, Roderick SL, Cohen DE. Structure and function of phosphatidylcholine transfer protein (PC-TP)/StarD2. Biochim Biophys Acta. 2007 Jun; 1771(6):654-62. PMID: 17499021.
    Citations: 31     Fields:    Translation:AnimalsCells
  87. Bravo I, Amigo L, Cohen DE, Nervi F, Rigotti A, Francone O, Zanlungo S. Role of plasma and liver cholesterol- and lipoprotein-metabolism determinants in LpX formation in the mouse. Biochim Biophys Acta. 2007 Jun; 1770(6):979-88. PMID: 17399905.
    Citations: 3     Fields:    Translation:Animals
  88. Pan HJ, Agate DS, King BL, Wu MK, Roderick SL, Leiter EH, Cohen DE. A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein. FEBS Lett. 2006 Oct 30; 580(25):5953-8. PMID: 17046758.
    Citations: 12     Fields:    Translation:AnimalsCells
  89. Wang WJ, Baez JM, Maurer R, Dansky HM, Cohen DE. Homozygous disruption of Pctp modulates atherosclerosis in apolipoprotein E-deficient mice. J Lipid Res. 2006 Nov; 47(11):2400-7. PMID: 16940277.
    Citations: 5     Fields:    Translation:AnimalsCells
  90. Cohen DE, Anania FA, Chalasani N. An assessment of statin safety by hepatologists. Am J Cardiol. 2006 Apr 17; 97(8A):77C-81C. PMID: 16581333.
    Citations: 82     Fields:    Translation:Humans
  91. Henkel A, Wei Z, Cohen DE, Green RM. Mice overexpressing hepatic Abcb11 rapidly develop cholesterol gallstones. Mamm Genome. 2005 Dec; 16(12):903-8. PMID: 16341669.
    Citations: 8     Fields:    Translation:Animals
  92. Wu MK, Cohen DE. Phosphatidylcholine transfer protein regulates size and hepatic uptake of high-density lipoproteins. Am J Physiol Gastrointest Liver Physiol. 2005 Dec; 289(6):G1067-74. PMID: 16099870.
    Citations: 8     Fields:    Translation:Animals
  93. Baez JM, Tabas I, Cohen DE. Decreased lipid efflux and increased susceptibility to cholesterol-induced apoptosis in macrophages lacking phosphatidylcholine transfer protein. Biochem J. 2005 May 15; 388(Pt 1):57-63. PMID: 15628972.
    Citations: 6     Fields:    Translation:AnimalsCells
  94. Wu MK, Cohen DE. Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice. Am J Physiol Gastrointest Liver Physiol. 2005 Sep; 289(3):G456-61. PMID: 15845870.
    Citations: 5     Fields:    Translation:AnimalsCells
  95. Roy S, Hyogo H, Yadav SK, Wu MK, Jelicks LA, Locker JD, Frank PG, Lisanti MP, Silver DL, Cohen DE. A biphasic response of hepatobiliary cholesterol metabolism to dietary fat at the onset of obesity in the mouse. Hepatology. 2005 Apr; 41(4):887-95. PMID: 15793852.
    Citations: 5     Fields:    Translation:AnimalsCells
  96. Wu MK, Hyogo H, Yadav SK, Novikoff PM, Cohen DE. Impaired response of biliary lipid secretion to a lithogenic diet in phosphatidylcholine transfer protein-deficient mice. J Lipid Res. 2005 Mar; 46(3):422-31. PMID: 15576839.
    Citations: 15     Fields:    Translation:AnimalsCells
  97. Dubrac S, Lear SR, Ananthanarayanan M, Balasubramaniyan N, Bollineni J, Shefer S, Hyogo H, Cohen DE, Blanche PJ, Krauss RM, Batta AK, Salen G, Suchy FJ, Maeda N, Erickson SK. Role of CYP27A in cholesterol and bile acid metabolism. J Lipid Res. 2005 Jan; 46(1):76-85. PMID: 15520450.
    Citations: 18     Fields:    Translation:Animals
  98. Shoda J, Inada Y, Tsuji A, Kusama H, Ueda T, Ikegami T, Suzuki H, Sugiyama Y, Cohen DE, Tanaka N. Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4. J Lipid Res. 2004 Oct; 45(10):1813-25. PMID: 15258199.
    Citations: 21     Fields:    Translation:HumansCells
  99. Vanpatten S, Karkanias GB, Rossetti L, Cohen DE. Intracerebroventricular leptin regulates hepatic cholesterol metabolism. Biochem J. 2004 Apr 15; 379(Pt 2):229-33. PMID: 14984364.
    Citations: 16     Fields:    Translation:Animals
  100. Figge A, Lammert F, Paigen B, Henkel A, Matern S, Korstanje R, Shneider BL, Chen F, Stoltenberg E, Spatz K, Hoda F, Cohen DE, Green RM. Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis. J Biol Chem. 2004 Jan 23; 279(4):2790-9. PMID: 14570929.
    Citations: 34     Fields:    Translation:Animals
  101. Wang DQ, Tazuma S, Cohen DE, Carey MC. Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse. Am J Physiol Gastrointest Liver Physiol. 2003 Sep; 285(3):G494-502. PMID: 12748061.
    Citations: 63     Fields:    Translation:Animals
  102. Hyogo H, Roy S, Cohen DE. Restoration of gallstone susceptibility by leptin in C57BL/6J ob/ob mice. J Lipid Res. 2003 Jun; 44(6):1232-40. PMID: 12671032.
    Citations: 8     Fields:    Translation:Animals
  103. Erickson SK, Lear SR, Deane S, Dubrac S, Huling SL, Nguyen L, Bollineni JS, Shefer S, Hyogo H, Cohen DE, Shneider B, Sehayek E, Ananthanarayanan M, Balasubramaniyan N, Suchy FJ, Batta AK, Salen G. Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice. J Lipid Res. 2003 May; 44(5):1001-9. PMID: 12588950.
    Citations: 45     Fields:    Translation:Animals
  104. Wolkoff AW, Cohen DE. Bile acid regulation of hepatic physiology: I. Hepatocyte transport of bile acids. Am J Physiol Gastrointest Liver Physiol. 2003 Feb; 284(2):G175-9. PMID: 12529265.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  105. Amigo L, Zanlungo S, Miquel JF, Glick JM, Hyogo H, Cohen DE, Rigotti A, Nervi F. Hepatic overexpression of sterol carrier protein-2 inhibits VLDL production and reciprocally enhances biliary lipid secretion. J Lipid Res. 2003 Feb; 44(2):399-407. PMID: 12576522.
    Citations: 14     Fields:    Translation:AnimalsCells
  106. Schubert W, Frank PG, Woodman SE, Hyogo H, Cohen DE, Chow CW, Lisanti MP. Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice. J Biol Chem. 2002 Oct 18; 277(42):40091-8. PMID: 12167625.
    Citations: 117     Fields:    Translation:AnimalsCells
  107. Hyogo H, Roy S, Paigen B, Cohen DE. Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts. J Biol Chem. 2002 Sep 13; 277(37):34117-24. PMID: 12114517.
    Citations: 20     Fields:    Translation:Animals
  108. Roderick SL, Chan WW, Agate DS, Olsen LR, Vetting MW, Rajashankar KR, Cohen DE. Structure of human phosphatidylcholine transfer protein in complex with its ligand. Nat Struct Biol. 2002 Jul; 9(7):507-11. PMID: 12055623.
    Citations: 79     Fields:    Translation:HumansCells
  109. Hyogo H, Tazuma S, Cohen DE. Cholesterol gallstones. Curr Opin Gastroenterol. 2002 May; 18(3):366-71. PMID: 17033308.
    Citations: 1     Fields:    
  110. Chan WW, Roderick SL, Cohen DE. Human phosphatidylcholine transfer protein: purification, crystallization and preliminary X-ray diffraction data. Biochim Biophys Acta. 2002 Apr 01; 1596(1):1-5. PMID: 11983415.
    Citations: 1     Fields:    Translation:HumansCells
  111. Baez JM, Barbour SE, Cohen DE. Phosphatidylcholine transfer protein promotes apolipoprotein A-I-mediated lipid efflux in Chinese hamster ovary cells. J Biol Chem. 2002 Feb 22; 277(8):6198-206. PMID: 11751880.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
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