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profileChester Allan Alper, M.D.

TitleProfessor of Pediatrics
InstitutionImmune Disease Institute
DepartmentPediatrics
AddressImmune Disease Institute
Pediatrics, WAB-132A
200 Longwood Ave
Boston MA 02115
Phone617/713-8850
Fax617/713-8852
vCardDownload vCard (login for email)

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Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01AI035630     (ALPER, CHESTER ALLAN)Sep 30, 1995 - Jul 31, 1999
NIH/NIAID
NONREPONSE TO THE HEPATITIS B VACCINE
Role: Principal Investigator

S15CA053688     (ALPER, CHESTER ALLAN)Aug 1, 1990 - Jul 31, 1992
NIH/NCI
SMALL INSTRUMENTATION GRANT
Role: Principal Investigator

S15HL043990     (ALPER, CHESTER ALLAN)Sep 1, 1989 - Aug 31, 1991
NIH/NHLBI
SMALL INSTRUMENTATION PROGRAM
Role: Principal Investigator

S10RR004828     (ALPER, CHESTER ALLAN)Apr 24, 1989 - Apr 23, 1990
NIH/NCRR
DNA SYNTHESIZER/SEQUENCING SYSTEM
Role: Principal Investigator

S15HL041723     (ALPER, CHESTER ALLAN)Jun 1, 1988 - May 31, 1989
NIH/NHLBI
LASER DENSITOMETER--ISOCRATIC TITANIUM FLUID PATH SYSTEM
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Alper CA, Larsen CE. Pedigree-Defined Haplotypes and Their Applications to Genetic Studies. Methods Mol Biol. 2017; 1551:113-127. PMID: 28138843.
    View in: PubMed
  2. Larsen CE, Alford DR, Trautwein MR, Jalloh YK, Tarnacki JL, Kunnenkeri SK, Fici DA, Yunis EJ, Awdeh ZL, Alper CA. Dominant sequences of human major histocompatibility complex conserved extended haplotypes from HLA-DQA2 to DAXX. PLoS Genet. 2014 Oct; 10(10):e1004637. PMID: 25299700; PMCID: PMC4191933.
  3. Granados-Montiel J, Zúñiga J, Azocar J, Feris EJ, Terreros D, Larsen CE, Clavijo OP, Cruz-Lagunas A, Middleton D, Alper CA, Pandey JP, Yunis EJ. Interaction between immunoglobulin allotypes and NK receptor genes in diabetes post-hepatitis C virus infection. Immunobiology. 2011 Jun; 216(6):686-91. PMID: 21281981; PMCID: PMC3089690.
  4. Szilágyi A, Bánlaki Z, Pozsonyi E, Yunis EJ, Awdeh ZL, Hossó A, Rajczy K, Larsen CE, Fici DA, Alper CA, Füst G. Frequent occurrence of conserved extended haplotypes (CEHs) in two Caucasian populations. Mol Immunol. 2010 Jun; 47(10):1899-904. PMID: 20409590.
    View in: PubMed
  5. Zúñiga J, Romero V, Azocar J, Terreros D, Vargas-Rojas MI, Torres-García D, Jiménez-Alvarez L, Vargas-Alarcón G, Granados-Montiel J, Husain Z, Chung RT, Alper CA, Yunis EJ. Protective KIR-HLA interactions for HCV infection in intravenous drug users. Mol Immunol. 2009 Aug; 46(13):2723-7. PMID: 19552960; PMCID: PMC2813779.
  6. Husain Z, Kelly MA, Eisenbarth GS, Pugliese A, Awdeh ZL, Larsen CE, Alper CA. The MHC type 1 diabetes susceptibility gene is centromeric to HLA-DQB1. J Autoimmun. 2008 Jun; 30(4):266-72. PMID: 18065200.
    View in: PubMed
  7. Romero V, Larsen CE, Duke-Cohan JS, Fox EA, Romero T, Clavijo OP, Fici DA, Husain Z, Almeciga I, Alford DR, Awdeh ZL, Zuñiga J, El-Dahdah L, Alper CA, Yunis EJ. Genetic fixity in the human major histocompatibility complex and block size diversity in the class I region including HLA-E. BMC Genet. 2007 Apr 12; 8:14. PMID: 17430593; PMCID: PMC1853106.
  8. Awdeh ZL, Yunis EJ, Audeh MJ, Fici D, Pugliese A, Larsen CE, Alper CA. A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease. J Autoimmun. 2006 Nov; 27(3):174-81. PMID: 17052889.
    View in: PubMed
  9. Alper CA, Husain Z, Larsen CE, Dubey DP, Stein R, Day C, Baker A, Beyan H, Hawa M, Ola TO, Leslie RD. Incomplete penetrance of susceptibility genes for MHC-determined immunoglobulin deficiencies in monozygotic twins discordant for type 1 diabetes. J Autoimmun. 2006 Sep; 27(2):89-95. PMID: 17029885; PMCID: PMC1810396.
  10. Bilbao JR, Calvo B, Aransay AM, Martin-Pagola A, Perez de Nanclares G, Aly TA, Rica I, Vitoria JC, Gaztambide S, Noble J, Fain PR, Awdeh ZL, Alper CA, Castaño L. Conserved extended haplotypes discriminate HLA-DR3-homozygous Basque patients with type 1 diabetes mellitus and celiac disease. Genes Immun. 2006 Oct; 7(7):550-4. PMID: 16929349.
    View in: PubMed
  11. Husain Z, Holodick N, Day C, Szymanski I, Alper CA. Increased apoptosis of CD20+ IgA + B cells is the basis for IgA deficiency: the molecular mechanism for correction in vitro by IL-10 and CD40L. J Clin Immunol. 2006 Mar; 26(2):113-25. PMID: 16758339.
    View in: PubMed
  12. Alper CA, Larsen CE, Dubey DP, Awdeh ZL, Fici DA, Yunis EJ. The haplotype structure of the human major histocompatibility complex. Hum Immunol. 2006 Jan-Feb; 67(1-2):73-84. PMID: 16698428.
    View in: PubMed
  13. Awdeh ZL, Alper CA. Mendelian inheritance of polygenic diseases: a hypothetical basis for increasing incidence. Med Hypotheses. 2005; 64(3):495-8. PMID: 15617855.
    View in: PubMed
  14. Larsen CE, Alper CA. The genetics of HLA-associated disease. Curr Opin Immunol. 2004 Oct; 16(5):660-7. PMID: 15342014.
    View in: PubMed
  15. Pinto C, Smith AG, Larsen CE, Fernández-Viña M, Husain Z, Clavijo OP, Wang ZC, Nisperos B, Hansen JA, Alper CA, Yunis EJ. HLA-Cw*0409N is associated with HLA-A*2301 and HLA-B*4403-carrying haplotypes. Hum Immunol. 2004 Feb; 65(2):181-7. PMID: 14969773.
    View in: PubMed
  16. Yunis EJ, Larsen CE, Fernandez-Viña M, Awdeh ZL, Romero T, Hansen JA, Alper CA. Inheritable variable sizes of DNA stretches in the human MHC: conserved extended haplotypes and their fragments or blocks. Tissue Antigens. 2003 Jul; 62(1):1-20. PMID: 12859592.
    View in: PubMed
  17. Alper CA, Xu J, Cosmopoulos K, Dolinski B, Stein R, Uko G, Larsen CE, Dubey DP, Densen P, Truedsson L, Sturfelt G, Sjöholm AG. Immunoglobulin deficiencies and susceptibility to infection among homozygotes and heterozygotes for C2 deficiency. J Clin Immunol. 2003 Jul; 23(4):297-305. PMID: 12959222.
    View in: PubMed
  18. Crawford K, Stark A, Kitchens B, Sternheim K, Pantazopoulos V, Triantafellow E, Wang Z, Vasir B, Larsen CE, Gabuzda D, Reinherz E, Alper CA. CD2 engagement induces dendritic cell activation: implications for immune surveillance and T-cell activation. Blood. 2003 Sep 01; 102(5):1745-52. PMID: 12714509.
    View in: PubMed
  19. Alper CA, Kevy SV, Konugres AA. Louis K. Diamond. Transfusion. 2002 Oct; 42(10):1381-2. PMID: 12449155.
    View in: PubMed
  20. Husain Z, Alper CA, Yunis EJ, Dubey DP. Complex expression of natural killer receptor genes in single natural killer cells. Immunology. 2002 Jul; 106(3):373-80. PMID: 12100725; PMCID: PMC1782738.
  21. Husain Z, Levitan E, Larsen CE, Mirza NM, Younes S, Yunis EJ, Alper CA, Dubey DP. HLA-Cw7 zygosity affects the size of a subset of CD158b+ natural killer cells. J Clin Immunol. 2002 Jan; 22(1):28-36. PMID: 11958591.
    View in: PubMed
  22. Uko GP, Fraser PA, Awdeh ZL, Fici DA, Crawford KD, Larsen CE, Alper CA. Hepatitis B surface antigen- and tetanus toxoid-specific clonal expansion of CD4+ cells in vitro determined by TCRBV CDR3 length and nucleotide sequence. Genes Immun. 2001 Feb; 2(1):11-9. PMID: 11294562.
    View in: PubMed
  23. Alper CA, Marcus-Bagley D, Awdeh Z, Kruskall MS, Eisenbarth GS, Brink SJ, Katz AJ, Stein R, Bing DH, Yunis EJ, Schur PH. Prospective analysis suggests susceptibility genes for deficiencies of IgA and several other immunoglobulins on the [HLA-B8, SC01, DR3] conserved extended haplotype. Tissue Antigens. 2000 Sep; 56(3):207-16. PMID: 11034556.
    View in: PubMed
  24. Alper CA, Awdeh Z. Incomplete penetrance of MHC susceptibility genes: prospective analysis of polygenic MHC-determined traits. Tissue Antigens. 2000 Sep; 56(3):199-206. PMID: 11034555.
    View in: PubMed
  25. Larsen CE, Xu J, Lee S, Dubey DP, Uko G, Yunis EJ, Alper CA. Complex cytokine responses to hepatitis B surface antigen and tetanus toxoid in responders, nonresponders and subjects naive to hepatitis B surface antigen. Vaccine. 2000 Jul 01; 18(26):3021-30. PMID: 10825606.
    View in: PubMed
  26. Calvo B, Castaño L, Marcus-Bagley D, Fici DA, Awdeh Z, Alper CA. The [HLA-B18, F1C30, DR3] conserved extended haplotype carries a susceptibility gene for IgD deficiency. J Clin Immunol. 2000 May; 20(3):216-20. PMID: 10941830.
    View in: PubMed
  27. Alper CA, Dubey DP, Yunis EJ, Awdeh Z. A simple estimate of the general population frequency of the MHC susceptibility gene for autoimmune polygenic disease. Exp Clin Immunogenet. 2000; 17(3):138-47. PMID: 10899739.
    View in: PubMed
  28. Crawford K, Alper CA. Genetics of the complement system. Rev Immunogenet. 2000; 2(3):323-38. PMID: 11256743.
    View in: PubMed
  29. Crawford K, Gabuzda D, Pantazopoulos V, Xu J, Clement C, Reinherz E, Alper CA. Circulating CD2+ monocytes are dendritic cells. J Immunol. 1999 Dec 01; 163(11):5920-8. PMID: 10570278.
    View in: PubMed
  30. Wang Z, Yunis D, Irigoyen M, Kitchens B, Bottaro A, Alt FW, Alper CA. Discordance between IgA switching at the DNA level and IgA expression at the mRNA level in IgA-deficient patients. Clin Immunol. 1999 Jun; 91(3):263-70. PMID: 10370371.
    View in: PubMed
  31. Fredrikson GN, Gullstrand B, Schneider PM, Witzel-Schlömp K, Sjöholm AG, Alper CA, Awdeh Z, Truedsson L. Characterization of non-expressed C4 genes in a case of complete C4 deficiency: identification of a novel point mutation leading to a premature stop codon. Hum Immunol. 1998 Nov; 59(11):713-9. PMID: 9796739.
    View in: PubMed
  32. Clavijo OP, Delgado JC, Awdeh ZL, Fici D, Turbay D, Alper CA, Truedsson L, Yunis EJ. HLA-Cw alleles associated with HLA extended haplotypes and C2 deficiency. Tissue Antigens. 1998 Sep; 52(3):282-5. PMID: 9802610.
    View in: PubMed
  33. Alper CA. A history of complement genetics. Exp Clin Immunogenet. 1998; 15(4):203-12. PMID: 10072630.
    View in: PubMed
  34. Chedid MG, Deulofeut H, Yunis DE, Lara-Marquez ML, Salazar M, Deulofeut R, Awdeh Z, Alper CA, Yunis EJ. Defect in Th1-like cells of nonresponders to hepatitis B vaccine. Hum Immunol. 1997 Nov; 58(1):42-51. PMID: 9438208.
    View in: PubMed
  35. Delgado JC, Hameed A, Yunis JJ, Bhol K, Rojas AI, Rehman SB, Khan AA, Ahmad M, Alper CA, Ahmed AR, Yunis EJ. Pemphigus vulgaris autoantibody response is linked to HLA-DQB1*0503 in Pakistani patients. Hum Immunol. 1997 Oct; 57(2):110-9. PMID: 9438202.
    View in: PubMed
  36. Mobini N, Yunis EJ, Alper CA, Yunis JJ, Delgado JC, Yunis DE, Firooz A, Dowlati Y, Bahar K, Gregersen PK, Ahmed AR. Identical MHC markers in non-Jewish Iranian and Ashkenazi Jewish patients with pemphigus vulgaris: possible common central Asian ancestral origin. Hum Immunol. 1997 Sep 15; 57(1):62-7. PMID: 9438197.
    View in: PubMed
  37. Simon S, Truedsson L, Marcus-Bagley D, Awdeh Z, Eisenbarth GS, Brink SJ, Yunis EJ, Alper CA. Relationship between protein complotypes and DNA variant haplotypes: complotype-RFLP constellations (CRC). Hum Immunol. 1997 Sep 15; 57(1):27-36. PMID: 9438192.
    View in: PubMed
  38. Turbay D, Lieberman J, Alper CA, Delgado JC, Corzo D, Yunis JJ, Yunis EJ. Tumor necrosis factor constellation polymorphism and clozapine-induced agranulocytosis in two different ethnic groups. Blood. 1997 Jun 01; 89(11):4167-74. PMID: 9166860.
    View in: PubMed
  39. Delgado JC, Yunis DE, Bozón MV, Salazar M, Deulofeut R, Turbay D, Mehra NK, Pasricha JS, Raval RS, Patel H, Shah BK, Bhol K, Alper CA, Ahmed AR, Yunis EJ. MHC class II alleles and haplotypes in patients with pemphigus vulgaris from India. Tissue Antigens. 1996 Dec; 48(6):668-72. PMID: 9008309.
    View in: PubMed
  40. Garcia-Merino A, Alper CA, Usuku K, Marcus-Bagley D, Lincoln R, Awdeh Z, Yunis EJ, Eisenbarth GS, Brink SJ, Hauser SL. Tumor necrosis factor (TNF) microsatellite haplotypes in relation to extended haplotypes, susceptibility to diseases associated with the major histocompatibility complex and TNF secretion. Hum Immunol. 1996 Sep 15; 50(1):11-21. PMID: 8872171.
    View in: PubMed
  41. Delgado JC, Turbay D, Yunis EJ, Yunis JJ, Morton ED, Bhol K, Norman R, Alper CA, Good RA, Ahmed R. A common major histocompatibility complex class II allele HLA-DQB1* 0301 is present in clinical variants of pemphigoid. Proc Natl Acad Sci U S A. 1996 Aug 06; 93(16):8569-71. PMID: 8710911; PMCID: PMC38713.
  42. Fraser PA, Yunis EJ, Alper CA. Excess admixture proportion of extended major histocompatability complex haplotypes of Caucasian origin among rheumatoid arthritis associated haplotypes in African Americans and Afro-Caribbeans. Ethn Health. 1996 May; 1(2):153-9. PMID: 9395559.
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  43. Pugliese A, Awdeh ZL, Alper CA, Jackson RA, Eisenbarth GS. The INS B allele (1,428 Fok I) is associated with reduced IDDM incidence in autoantibody-positive first degree relatives despite the presence of autoantibodies and high-risk HLA alleles. Transplant Proc. 1995 Dec; 27(6):3392. PMID: 8540014.
    View in: PubMed
  44. Corzo D, Yunis JJ, Salazar M, Lieberman JA, Howard A, Awdeh Z, Alper CA, Yunis EJ. The major histocompatibility complex region marked by HSP70-1 and HSP70-2 variants is associated with clozapine-induced agranulocytosis in two different ethnic groups. Blood. 1995 Nov 15; 86(10):3835-40. PMID: 7579351.
    View in: PubMed
  45. Awdeh ZL, Alper CA, Fici DA, Ronco P, Yunis EJ. Predictability of alloreactivity among unrelated individuals: role for HLA-DPB1. Tissue Antigens. 1995 Sep; 46(3 ( Pt 1)):180-6. PMID: 8525477.
    View in: PubMed
  46. Pugliese A, Gianani R, Moromisato R, Awdeh ZL, Alper CA, Erlich HA, Jackson RA, Eisenbarth GS. HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM. Diabetes. 1995 Jun; 44(6):608-13. PMID: 7789622.
    View in: PubMed
  47. Alper CA. The human immune response to hepatitis B surface antigen. Exp Clin Immunogenet. 1995; 12(3):171-81. PMID: 8534503.
    View in: PubMed
  48. Weiss RE, Sunthornthepvarakul T, Angkeow P, Marcus-Bagley D, Cox N, Alper CA, Refetoff S. Linkage of familial dysalbuminemic hyperthyroxinemia to the albumin gene in a large Amish kindred. J Clin Endocrinol Metab. 1995 Jan; 80(1):116-21. PMID: 7829599.
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  49. Salazar M, Deulofeut H, Granja C, Deulofeut R, Yunis DE, Marcus-Bagley D, Awdeh Z, Alper CA, Yunis EJ. Normal HBsAg presentation and T-cell defect in the immune response of nonresponders. Immunogenetics. 1995; 41(6):366-74. PMID: 7759133.
    View in: PubMed
  50. Gibson WT, Walter MA, Ahmed AR, Alper CA, Cox DW. The immunoglobulin heavy chain and disease association: application to pemphigus vulgaris. Hum Genet. 1994 Dec; 94(6):675-83. PMID: 7989043.
    View in: PubMed
  51. Pugliese A, Awdeh ZL, Alper CA, Jackson RA, Eisenbarth GS. The paternally inherited insulin gene B allele (1,428 FokI site) confers protection from insulin-dependent diabetes in families. J Autoimmun. 1994 Oct; 7(5):687-94. PMID: 7840860.
    View in: PubMed
  52. Yunis JJ, Mobini N, Yunis EJ, Alper CA, Deulofeut R, Rodriguez A, Foster CS, Marcus-Bagley D, Good RA, Ahmed AR. Common major histocompatibility complex class II markers in clinical variants of cicatricial pemphigoid. Proc Natl Acad Sci U S A. 1994 Aug 02; 91(16):7747-51. PMID: 8052655; PMCID: PMC44479.
  53. Pugliese A, Bugawan T, Moromisato R, Awdeh ZL, Alper CA, Jackson RA, Erlich HA, Eisenbarth GS. Two subsets of HLA-DQA1 alleles mark phenotypic variation in levels of insulin autoantibodies in first degree relatives at risk for insulin-dependent diabetes. J Clin Invest. 1994 Jun; 93(6):2447-52. PMID: 8200980; PMCID: PMC294453.
  54. Dubey DP, Alper CA, Mirza NM, Awdeh Z, Yunis EJ. Polymorphic Hh genes in the HLA-B(C) region control natural killer cell frequency and activity. J Exp Med. 1994 Apr 01; 179(4):1193-203. PMID: 8145038; PMCID: PMC2191452.
  55. Pugliese A, Solimena M, Awdeh ZL, Alper CA, Bugawan T, Erlich HA, De Camilli P, Eisenbarth GS. Association of HLA-DQB1*0201 with stiff-man syndrome. J Clin Endocrinol Metab. 1993 Dec; 77(6):1550-3. PMID: 8263140.
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  56. Ahmed AR, Yunis JJ, Marcus-Bagley D, Yunis EJ, Salazar M, Katz AJ, Awdeh Z, Alper CA. Major histocompatibility complex susceptibility genes for dermatitis herpetiformis compared with those for gluten-sensitive enteropathy. J Exp Med. 1993 Dec 01; 178(6):2067-75. PMID: 8245782; PMCID: PMC2191293.
  57. Truedsson L, Alper CA, Awdeh ZL, Johansen P, Sjöholm AG, Sturfelt G. Characterization of type I complement C2 deficiency MHC haplotypes. Strong conservation of the complotype/HLA-B-region and absence of disease association due to linked class II genes. J Immunol. 1993 Nov 15; 151(10):5856-63. PMID: 7901282.
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  58. Cascino I, D'Alfonso S, Cappello N, Giordano M, Pugliese A, Awdeh Z, Alper CA, Richiardi PM. Gametic association of HSP70-1 promoter region alleles and their inclusion in extended HLA haplotypes. Tissue Antigens. 1993 Aug; 42(2):62-6. PMID: 7903489.
    View in: PubMed
  59. Deulofeut H, Iglesias A, Mikael N, Bing DH, Awdeh Z, Yunis J, Marcus-Bagley D, Kruskall MS, Alper CA, Yunis EJ. Cellular recognition and HLA restriction of a midsequence HBsAg peptide in hepatitis B vaccinated individuals. Mol Immunol. 1993 Jul; 30(10):941-8. PMID: 8341285.
    View in: PubMed
  60. Ahmed AR, Mohimen A, Yunis EJ, Mirza NM, Kumar V, Beutner EH, Alper CA. Linkage of pemphigus vulgaris antibody to the major histocompatibility complex in healthy relatives of patients. J Exp Med. 1993 Feb 01; 177(2):419-24. PMID: 8426112; PMCID: PMC2190905.
  61. Yunis JJ, Salazar M, Delgado MB, Alper CA, Bing DH, Yunis EJ. HLA-DQA1, DQB1 and DPB1 alleles on HLA-DQ2- and DQ9-carrying extended haplotypes. Tissue Antigens. 1993 Jan; 41(1):37-41. PMID: 8096094.
    View in: PubMed
  62. Usuku K, Joshi N, Hatem CJ, Alper CA, Schoenfeld DA, Hauser SL. The human T-cell receptor beta-chain repertoire: longitudinal fluctuations and assessment in MHC matched populations. Immunogenetics. 1993; 38(3):193-8. PMID: 8099343.
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  63. Pugliese A, Awdeh ZL, Galluzzo A, Yunis EJ, Alper CA, Eisenbarth GS. No independent association between HSP70 gene polymorphism and IDDM. Diabetes. 1992 Jul; 41(7):788-91. PMID: 1351854.
    View in: PubMed
  64. Gianani R, Pugliese A, Bonner-Weir S, Shiffrin AJ, Soeldner JS, Erlich H, Awdeh Z, Alper CA, Jackson RA, Eisenbarth GS. Prognostically significant heterogeneity of cytoplasmic islet cell antibodies in relatives of patients with type I diabetes. Diabetes. 1992 Mar; 41(3):347-53. PMID: 1551494.
    View in: PubMed
  65. Awdeh ZL, Alper CA, Fici D, Eynon E, Bishara A, Yunis EJ. Predictability of alloreactivity among unrelated individuals. Tissue Antigens. 1992 Feb; 39(2):51-7. PMID: 1574798.
    View in: PubMed
  66. Kruskall MS, Alper CA, Awdeh Z, Yunis EJ, Marcus-Bagley D. The immune response to hepatitis B vaccine in humans: inheritance patterns in families. J Exp Med. 1992 Feb 01; 175(2):495-502. PMID: 1531063; PMCID: PMC2119114.
  67. Blumenthal M, Marcus-Bagley D, Awdeh Z, Johnson B, Yunis EJ, Alper CA. HLA-DR2, [HLA-B7, SC31, DR2], and [HLA-B8, SC01, DR3] haplotypes distinguish subjects with asthma from those with rhinitis only in ragweed pollen allergy. J Immunol. 1992 Jan 15; 148(2):411-6. PMID: 1729361.
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  68. Alper CA, Awdeh Z, Yunis EJ. Conserved, extended MHC haplotypes. Exp Clin Immunogenet. 1992; 9(2):58-71. PMID: 1489551.
    View in: PubMed
  69. Ahmed AR, Foster S, Zaltas M, Notani G, Awdeh Z, Alper CA, Yunis EJ. Association of DQw7 (DQB1*0301) with ocular cicatricial pemphigoid. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11579-82. PMID: 1763074; PMCID: PMC53179.
  70. Simon S, Awdeh Z, Campbell RD, Ronco P, Brink SJ, Eisenbarth GS, Yunis EJ, Alper CA. A restriction fragment of the C2 gene is a unique marker for C2 deficiency and the uncommon C2 allele C2*B (a marker for type 1 diabetes). J Clin Invest. 1991 Dec; 88(6):2142-5. PMID: 1684365; PMCID: PMC295824.
  71. Ahmed AR, Wagner R, Khatri K, Notani G, Awdeh Z, Alper CA, Yunis EJ. Major histocompatibility complex haplotypes and class II genes in non-Jewish patients with pemphigus vulgaris. Proc Natl Acad Sci U S A. 1991 Jun 01; 88(11):5056-60. PMID: 1675792; PMCID: PMC51806.
  72. Ziegler R, Alper CA, Awdeh ZL, Castano L, Brink SJ, Soeldner JS, Jackson RA, Eisenbarth GS. Specific association of HLA-DR4 with increased prevalence and level of insulin autoantibodies in first-degree relatives of patients with type I diabetes. Diabetes. 1991 Jun; 40(6):709-14. PMID: 2040387.
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  73. Varga L, Alper CA, Zam Z, Füst G. Decreased inhibition of immune precipitation by sera with the C2 B allotype. Clin Immunol Immunopathol. 1991 Apr; 59(1):65-71. PMID: 2019011.
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  74. Erlich HA, Griffith RL, Bugawan TL, Ziegler R, Alper C, Eisenbarth G. Implication of specific DQB1 alleles in genetic susceptibility and resistance by identification of IDDM siblings with novel HLA-DQB1 allele and unusual DR2 and DR1 haplotypes. Diabetes. 1991 Apr; 40(4):478-81. PMID: 2010048.
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  75. Egea E, Iglesias A, Salazar M, Morimoto C, Kruskall MS, Awdeh Z, Schlossman SF, Alper CA, Yunis EJ. The cellular basis for lack of antibody response to hepatitis B vaccine in humans. J Exp Med. 1991 Mar 01; 173(3):531-8. PMID: 1825504; PMCID: PMC2118833.
  76. Egea GE, Yunis I, Spies T, Strominger J, Awdeh ZL, Alper CA, Yunis EJ. Association of polymorphisms in the HLA-B region with extended haplotypes. Immunogenetics. 1991; 33(1):4-11. PMID: 1671666.
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  77. Fraser PA, Awdeh ZL, Ronco P, Simon S, Moore B, Fici D, Marcus-Bagley D, Yunis EJ, Alper CA. C4B gene polymorphisms among African and African-American HLA-Bw42-DRw18 haplotypes. Immunogenetics. 1991; 34(1):52-6. PMID: 1677346.
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  78. Ahmed AR, Yunis EJ, Khatri K, Wagner R, Notani G, Awdeh Z, Alper CA. Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with pemphigus vulgaris. Proc Natl Acad Sci U S A. 1990 Oct; 87(19):7658-62. PMID: 2217197; PMCID: PMC54807.
  79. Fronek Z, Timmerman LA, Alper CA, Hahn BH, Kalunian K, Peterlin BM, McDevitt HO. Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus. Arthritis Rheum. 1990 Oct; 33(10):1542-53. PMID: 1977392.
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  80. Schur PH, Marcus-Bagley D, Awdeh Z, Yunis EJ, Alper CA. The effect of ethnicity on major histocompatibility complex complement allotypes and extended haplotypes in patients with systemic lupus erythematosus. Arthritis Rheum. 1990 Jul; 33(7):985-92. PMID: 2369433.
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  81. Ahmed AR, Yunis EJ, Alper CA. Complotypes in pemphigus vulgaris: differences between Jewish and non-Jewish patients. Hum Immunol. 1990 Apr; 27(4):298-304. PMID: 2318675.
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  82. Fraser PA, Stern S, Larson MG, Marcus-Bagley D, Awdeh Z, Glass DN, Alper CA. HLA extended haplotypes in childhood and adult onset HLA-DR4-associated arthropathies. Tissue Antigens. 1990 Feb; 35(2):56-9. PMID: 2343452.
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  83. Yunis JJ, Wescott M, Lechin SJ, Alosco SM, Awdeh Z, Alper CA, Yunis EJ. HLA-DQ RFLP variants of five HLA-DQw2-bearing major histocompatibility complex extended haplotypes. Immunogenetics. 1990; 32(2):88-95. PMID: 1975800.
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  84. Mauff G, Alper CA, Dawkins R, Doxiadis G, Giles CM, Hauptmann G, Rittner C, Schneider PM. C4 nomenclature statement (1990). Complement Inflamm. 1990; 7(4-6):261-8. PMID: 2088664.
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  85. Fraser PA, Moore B, Stein R, Alosco S, Johnson AH, Marcus-Bagley D, Awdeh Z, Yunis EJ, Alper CA. Complotypes in individuals of African origin: frequencies and possible extended MHC haplotypes. Immunogenetics. 1990; 31(2):89-93. PMID: 2303279.
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  86. Kruskall MS, Yunis EJ, Watson A, Awdeh Z, Alper CA. Major histocompatibility complex markers and red cell antibodies to the Rh (D) antigen. Absence of association. Transfusion. 1990 Jan; 30(1):15-9. PMID: 2104997.
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  87. Mitus AJ, Stein R, Rappeport JM, Antin JH, Weinstein HJ, Alper CA, Smith BR. Monoclonal and oligoclonal gammopathy after bone marrow transplantation. Blood. 1989 Dec; 74(8):2764-8. PMID: 2819246.
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  88. Alper CA, Kruskall MS, Marcus-Bagley D, Craven DE, Katz AJ, Brink SJ, Dienstag JL, Awdeh Z, Yunis EJ. Genetic prediction of nonresponse to hepatitis B vaccine. N Engl J Med. 1989 Sep 14; 321(11):708-12. PMID: 2528067.
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  89. Hauser SL, Fleischnick E, Weiner HL, Marcus D, Awdeh Z, Yunis EJ, Alper CA. Extended major histocompatibility complex haplotypes in patients with multiple sclerosis. Neurology. 1989 Feb; 39(2 Pt 1):275-7. PMID: 2783768.
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  90. Alper CA, Awdeh ZL, Yunis EJ. Complotypes and extended haplotypes in laboratory medicine. Complement Inflamm. 1989; 6(1):8-18. PMID: 2650992.
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  91. Truedsson L, Awdeh Z, Yunis EJ, Mrose S, Moore B, Alper CA. Quantitative variation of C4 variant proteins associated with many MHC haplotypes. Immunogenetics. 1989; 30(6):414-21. PMID: 2574157.
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  92. Fronek Z, Timmerman LA, Alper CA, Hahn BH, Kalunian K, Peterlin BM, McDevitt HO. Major histocompatibility complex associations with systemic lupus erythematosus. Am J Med. 1988 Dec 23; 85(6A):42-4. PMID: 2904762.
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  93. Dasgupta JD, Relias V, Awdeh ZL, Alper CA, Yunis EJ. Two variants of DRw52, DR3, and DQw2 specificities distinguish two different DR3-bearing extended haplotypes. Hum Immunol. 1988 Feb; 21(2):133-42. PMID: 2835344.
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  94. Hayes DF, Sekine H, Marcus D, Alper CA, Kufe DW. Genetically determined polymorphism of the circulating human breast cancer-associated DF3 antigen. Blood. 1988 Feb; 71(2):436-40. PMID: 3337905.
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  95. Sklarin PM, Awdeh ZL, Alper CA. An immunoblotting technique for direct visualization of Chido and Rodgers reactivity on C4 variants after electrophoresis. Vox Sang. 1988; 54(1):43-6. PMID: 2450426.
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  96. Whitehead AS, Truedsson L, Schneider PM, Awdeh ZL, Fleischnick E, Blumenthal M, Costello W, Gerald PS, Yunis EJ, Alper CA. The distribution of human C4 DNA variants in relation to major histocompatibility complex alleles and extended haplotypes. Hum Immunol. 1988 Jan; 21(1):23-32. PMID: 3163333.
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  97. Wisnieski JJ, Nathanson MH, Anderson JE, Davis AE, Alper CA, Naff GB. Metabolism of C4 and linkage analysis in a kindred with hereditary incomplete C4 deficiency. Arthritis Rheum. 1987 Aug; 30(8):919-26. PMID: 3477232.
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  98. Boustany RM, Fleischnick E, Alper CA, Marazita ML, Spence MA, Martin JB, Kolodny EH. The autosomal dominant form of "pure" familial spastic paraplegia: clinical findings and linkage analysis of a large pedigree. Neurology. 1987 Jun; 37(6):910-5. PMID: 3587641.
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  99. Alper CA. Inherited deficiencies of complement components in man. Immunol Lett. 1987 Feb; 14(3):175-81. PMID: 3570360.
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  100. Layrisse Z, White C, Gunczler P, Gafaro Valera L, Arias S, Yunis EJ, Alper CA, Awdeh ZL. Sharing of MHC haplotypes among apparently unrelated patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Immunogenetics. 1987; 25(2):99-103. PMID: 3493216.
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  101. Wescott MZ, Awdeh ZL, Yunis EJ, Alper CA. Molecular analysis distinguishes two HLA-DR3-bearing major histocompatibility complex extended haplotypes. Immunogenetics. 1987; 26(6):370-4. PMID: 2889669.
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  102. Granados J, Awdeh ZL, Chen JH, Giles CM, Balner H, Yunis EJ, Alper CA. There are two C4 genetic loci and a null allele in the chimpanzee. Immunogenetics. 1987; 26(6):344-50. PMID: 3666845.
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  103. Kruskall MS, Eynon EE, Awdeh Z, Alper CA, Yunis EJ. Identification of HLA-B44 subtypes associated with extended MHC haplotypes. Immunogenetics. 1987; 26(4-5):216-9. PMID: 3653939.
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  104. Carroll MC, Alper CA. Polymorphism and molecular genetics of human C4. Br Med Bull. 1987 Jan; 43(1):50-65. PMID: 3315101.
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  105. Alper CA, Fleischnick E, Awdeh Z, Katz AJ, Yunis EJ. Extended major histocompatibility complex haplotypes in patients with gluten-sensitive enteropathy. J Clin Invest. 1987 Jan; 79(1):251-6. PMID: 3793924; PMCID: PMC424034.
  106. Schneider PM, Carroll MC, Alper CA, Rittner C, Whitehead AS, Yunis EJ, Colten HR. Polymorphism of the human complement C4 and steroid 21-hydroxylase genes. Restriction fragment length polymorphisms revealing structural deletions, homoduplications, and size variants. J Clin Invest. 1986 Sep; 78(3):650-7. PMID: 3018042; PMCID: PMC423642.
  107. Eynon EE, Yang SY, Cronin CR, Alosco SM, Alper CA, Yunis EJ. Characterization of HLA-Bw73 by serology and one-dimensional isoelectric focusing patterns. Hum Immunol. 1986 Aug; 16(4):356-63. PMID: 2428782.
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  108. Reinitz E, Lawrence M, Diamond B, Keiser H, Alper C. Arthritis and antinuclear antibodies (ANA) with inherited deficiency of the sixth component of complement (C6). Ann Rheum Dis. 1986 May; 45(5):431-4. PMID: 3487293; PMCID: PMC1001906.
  109. Alper CA, Awdeh ZL, Yunis EJ. Complotypes, extended haplotypes, male segregation distortion, and disease markers. Hum Immunol. 1986 Apr; 15(4):366-73. PMID: 3516938.
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  110. Melamed J, Alper CA, Cicardi M, Rosen FS. The metabolism of C1 inhibitor and C1q in patients with acquired C1-inhibitor deficiency. J Allergy Clin Immunol. 1986 Feb; 77(2):322-6. PMID: 3484761.
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  111. Alper CA. Genetics of the complement system. Ann N Y Acad Sci. 1986; 475:32-46. PMID: 3538974.
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  112. Alper CA, Awdeh Z, Raum D, Yunis EJ. Complement genes of the major histocompatibility complex (complotypes), extended haplotypes and disease markers. Biochem Soc Symp. 1986; 51:19-28. PMID: 3493006.
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  113. Awdeh ZL, Alper CA, Eynon E, Alosco SM, Stein R, Yunis EJ. Unrelated individuals matched for MHC extended haplotypes and HLA-identical siblings show comparable responses in mixed lymphocyte culture. Lancet. 1985 Oct 19; 2(8460):853-6. PMID: 2864576.
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  114. Eisenbarth GS, Srikanta S, Fleischnick E, Ganda OP, Jackson RA, Brink SJ, Soeldner JS, Yunis EJ, Alper C. Progressive autoimmune beta cell insufficiency: occurrence in the absence of high-risk HLA alleles DR3, DR4. Diabetes Care. 1985 Sep-Oct; 8(5):477-80. PMID: 3876922.
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  115. Rao CP, Minta JO, Laski B, Alper CA, Gelfand EW. Inherited C8 beta subunit deficiency in a patient with recurrent meningococcal infections: in vivo functional kinetic analysis of C8. Clin Exp Immunol. 1985 Apr; 60(1):183-90. PMID: 3924449; PMCID: PMC1577010.
  116. Alper CA, Awdeh ZL, Raum DD, Yunis EJ. Possible human analogs of the murine T/t complex. Exp Clin Immunogenet. 1985; 2(2):125-36. PMID: 3917226.
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  117. Yunis EJ, Awdeh Z, Johnson A, Suciu-Foca N, Robinson MA, Hartzman R, Raum D, Fleischnick E, Alper CA. Complotype genetic loci segregate more frequently with HLA-DR than with HLA-B. Immunogenetics. 1985; 21(1):25-31. PMID: 3871424.
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  118. Alper CA, Fleischnick E, Awdeh Z, Raum D, Crigler JF, Gerald PS, Yunis EJ. Extended MHC haplotypes in salt-losing 21-hydroxylase deficiency. Ann N Y Acad Sci. 1985; 458:28-35. PMID: 3879127.
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  119. Muir WA, Hedrick S, Alper CA, Ratnoff OD, Schacter B, Wisnieski JJ. Inherited incomplete deficiency of the fourth component of complement (C4) determined by a gene not linked to human histocompatibility leukocyte antigens. J Clin Invest. 1984 Oct; 74(4):1509-14. PMID: 6480834; PMCID: PMC425321.
  120. Raum D, Awdeh Z, Yunis EJ, Alper CA, Gabbay KH. Extended major histocompatibility complex haplotypes in type I diabetes mellitus. J Clin Invest. 1984 Aug; 74(2):449-54. PMID: 6746903; PMCID: PMC370496.
  121. Srikanta S, Ganda OP, Jackson RA, Brink SJ, Fleischnick E, Yunis E, Alper C, Soeldner JS, Eisenbarth GS. Pre-type 1 (insulin-dependent) diabetes: common endocrinological course despite immunological and immunogenetic heterogeneity. Diabetologia. 1984 Jul; 27 Suppl:146-8. PMID: 6383919.
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  122. Granados J, Cramer DV, Caputo JB, Marcus D, Alper CA. Genetic polymorphism of the sixth component (C6) of rat complement. J Immunol. 1984 Jul; 133(1):405-7. PMID: 6586834.
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  123. Raum D, Surgenor T, Awdeh Z, Marcus D, Blumenthal M, Yunis EJ, Alper CA. An unusual "morphologic" variant of BF S. Am J Hum Genet. 1984 Mar; 36(2):346-51. PMID: 6585138; PMCID: PMC1684408.
  124. Whitehead AS, Woods DE, Fleischnick E, Chin JE, Yunis EJ, Katz AJ, Gerald PS, Alper CA, Colten HR. DNA polymorphism of the C4 genes. A new marker for analysis of the major histocompatibility complex. N Engl J Med. 1984 Jan 12; 310(2):88-91. PMID: 6581384.
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  125. Alper CA, Rosen FS. Inherited deficiencies of complement proteins in man. Springer Semin Immunopathol. 1984; 7(2-3):251-61. PMID: 6238435.
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  126. Raum DD, Awdeh ZL, Page PL, Yunis EJ, Alper CA. MHC determinants of response to Rh immunization. J Immunol. 1984 Jan; 132(1):157-9. PMID: 6197442.
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  127. Raum D, Awdeh Z, Anderson J, Strong L, Granados J, Teran L, Giblett E, Yunis EJ, Alper CA. Human C4 haplotypes with duplicated C4A or C4B. Am J Hum Genet. 1984 Jan; 36(1):72-9. PMID: 6607672; PMCID: PMC1684397.
  128. Matsui Y, Alosco SM, Awdeh Z, Duquesnoy RJ, Page PL, Hartzman RJ, Alper CA, Yunis EJ. Linkage disequilibrium of HLA-SB1 with the HLA-A1, B8, DR3, SCO1 and of HLA-SB4 with the HLA-A26, Bw38, Dw10, DR4, SC21 extended haplotypes. Immunogenetics. 1984; 20(6):623-31. PMID: 6239824.
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  129. Dias da Silva W, Calich VL, Kipnis TL, Rosen FS, Alper CA. Complement in the serum and venom of Brazilian snakes (Crotalidae). Acta Pathol Microbiol Immunol Scand Suppl. 1984; 284:97-103. PMID: 6587747.
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  130. Alper CA, Marcus D, Raum D, Petersen BH, Spira TJ. Genetic polymorphism in C8 beta-chains. Evidence for two unlinked genetic loci for the eighth component of human complement (C8). J Clin Invest. 1983 Nov; 72(5):1526-31. PMID: 6415112; PMCID: PMC370440.
  131. Yunis EJ, Awdeh Z, Raum D, Alper CA. The MHC in human bone marrow allotransplantation. Clin Haematol. 1983 Oct; 12(3):641-80. PMID: 6227438.
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  132. Mauff G, Alper CA, Awdeh Z, Batchelor JR, Bertrams J, Bruun-Petersen G, Dawkins RL, Démant P, Edwards J, Grosse-Wilde H, Hauptmann G, Klouda P, Lamm L, Mollenhauer E, Nerl C, Olaisen B, O'Neill G, Rittner C, Roos MH, Skanes V, Teisberg P, Wells L. Statement on the nomenclature of human C4 allotypes. Immunobiology. 1983 Mar; 164(2):184-91. PMID: 6852863.
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  133. Fleischnick E, Awdeh ZL, Raum D, Granados J, Alosco SM, Crigler JF, Gerald PS, Giles CM, Yunis EJ, Alper CA. Extended MHC haplotypes in 21-hydroxylase-deficiency congenital adrenal hyperplasia: shared genotypes in unrelated patients. Lancet. 1983 Jan 22; 1(8317):152-6. PMID: 6130199.
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  134. Awdeh ZL, Raum D, Yunis EJ, Alper CA. Extended HLA/complement allele haplotypes: evidence for T/t-like complex in man. Proc Natl Acad Sci U S A. 1983 Jan; 80(1):259-63. PMID: 6401863; PMCID: PMC393352.
  135. Alper CA, Raum D, Karp S, Awdeh ZL, Yunis EJ. Serum complement 'supergenes' of the major histocompatibility complex in man (complotypes). Vox Sang. 1983; 45(1):62-7. PMID: 6554026.
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  136. Alper CA, Awdeh ZL, Raum DD, Yunis EJ. Extended major histocompatibility complex haplotypes in man: role of alleles analogous to murine t mutants. Clin Immunol Immunopathol. 1982 Aug; 24(2):276-85. PMID: 6811180.
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  137. Chao FC, Tullis JL, Alper CA, Glynn RJ, Silbert JE. Alteration in plasma proteins and platelet functions with aging and cigarette smoking in healthy men. Thromb Haemost. 1982 Jun 28; 47(3):259-64. PMID: 6981228.
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  138. Ballow M, McLean RH, Yunis EJ, Awdeh ZL, O'Neill GJ, Einarson M, Alper CA. C4 polymorphism and HLA linkage: studies in a family with hereditary C4 deficiency. Clin Immunol Immunopathol. 1981 Sep; 20(3):354-60. PMID: 7341033.
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  139. Arnaout MA, Luscinskas FW, Lionetti FJ, Alper CA, Valeri CR. Alternative complement pathway-dependent ingestion of fluolite particles by human granulocytes. J Immunol. 1981 Jul; 127(1):278-81. PMID: 6787126.
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  140. Mann J, O'Brien R, Hostetter MK, Alper CA, Rosen FS, Babior BM. The third component of complement: covalent attachment of a radioactive sugar to the labile binding site of C3 via the alternative pathway. J Immunol. 1981 Jun; 126(6):2370-2. PMID: 6785350.
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  141. Colten HR, Alper CA, Rosen FS. Genetics and biosynthesis of complement proteins. N Engl J Med. 1981 Mar 12; 304(11):653-6. PMID: 6450325.
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  142. Raum DD, Awdeh ZL, Glass D, Yunis E, Alper CA. The location of C2, C4, and BF relative to HLA-B and HLA-D. Immunogenetics. 1981 Mar 01; 12(5-6):473-83. PMID: 7216322.
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  143. Awdeh ZL, Raum DD, Glass D, Agnello V, Schur PH, Johnston RB, Gelfand EW, Ballow M, Yunis E, Alper CA. Complement-human histocompatibility antigen haplotypes in C2 deficiency. J Clin Invest. 1981 Feb; 67(2):581-3. PMID: 7462431; PMCID: PMC370603.
  144. Raum D, Awdeh Z, Alper CA. BF types and the mode of inheritance of insulin-dependent diabetes mellitus (IDDM). Immunogenetics. 1981; 12(1-2):59-74. PMID: 7009418.
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  145. Awdeh ZL, Ochs HD, Alper CA. Genetic analysis of C4 deficiency. J Clin Invest. 1981 Jan; 67(1):260-3. PMID: 7451653; PMCID: PMC371595.
  146. Raum D, Marcus D, Alper CA. Genetic polymorphism of human plasminogen. Am J Hum Genet. 1980 Sep; 32(5):681-9. PMID: 7424908; PMCID: PMC1686101.
  147. Awdeh ZL, Alper CA. Inherited structural polymorphism of the fourth component of human complement. Proc Natl Acad Sci U S A. 1980 Jun; 77(6):3576-80. PMID: 6932037; PMCID: PMC349660.
  148. Raum D, Marcus D, Alper CA, Levey R, Taylor PD, Starzl TE. Synthesis of human plasminogen by the liver. Science. 1980 May 30; 208(4447):1036-7. PMID: 6990488; PMCID: PMC2981173.
  149. Alper CA, Raum D, Awdeh ZL, Petersen BH, Taylor PD, Starzl TE. Studies of hepatic synthesis in vivo of plasma proteins, including orosomucoid, transferrin, alpha 1-antitrypsin, C8, and factor B. Clin Immunol Immunopathol. 1980 May; 16(1):84-9. PMID: 6769626.
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  150. Awdeh ZL, Alper CA. Inherited polymorphism of human C4 as revealed by desialyzation. Immunobiology. 1980; 158(1-2):35-41. PMID: 7203518.
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  151. Raum D, Donaldson VH, Rosen FS, Alper CA. Genetics of complement. Curr Top Hematol. 1980; 3:111-74. PMID: 7035077.
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  152. Mauff G, Alper CA, Hobart M, Kühnl P, Kunstmann G, Meo T, Olving JH, Rittner C. Statement on the nomenclature of human C6 polymorphism. Immunobiology. 1980; 158(1-2):139-43. PMID: 7203515.
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  153. Raum D, Balner H, Petersen BH, Alper CA. Genetic polymorphism of serum complement components in the chimpanzee. Immunogenetics. 1980; 10(5):455-68. PMID: 22457919.
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  154. Awdeh ZL, Raum D, Alper CA. Genetic polymorphism of human complement C4 and detection of heterozygotes. Nature. 1979 Nov 08; 282(5735):205-7. PMID: 492334.
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  155. Raum D, Spence MA, Balavitch D, Tideman S, Merritt AD, Taggart RT, Petersen BH, Day NK, Alper CA. Genetic control of the eighth component of complement. J Clin Invest. 1979 Sep; 64(3):858-65. PMID: 468996; PMCID: PMC372192.
  156. Raum D, Alper CA, Stein R, Gabbay KH. Genetic marker for insulin-dependent diabetes mellitus. Lancet. 1979 Jun 09; 1(8128):1208-10. PMID: 87677.
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  157. Raum D, Glass D, Carpenter CB, Schur PH, Alper CA. Mapping of the structural gene for the second component of complement with respect to the human major histocompatibility complex. Am J Hum Genet. 1979 Jan; 31(1):35-41. PMID: 312013; PMCID: PMC1685669.
  158. Raum D, Glass D, Agnello V, Schur P, Alper CA. Congenital deficiency of C2 and factor B. N Engl J Med. 1978 Dec 07; 299(23):1313. PMID: 714103.
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  159. Pariser KM, Raum D, Berkman EM, Alper CA, Agnello V. Evidence for a silent or null gene in hereditary C2 deficiency. J Immunol. 1978 Dec; 121(6):2580-1. PMID: 722085.
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  160. Davis AE, Gelfand EW, Schur PH, Rosen FS, Alper CA. IgG subclass studies of C3 nephritic factor. Clin Immunol Immunopathol. 1978 Sep; 11(1):98-101. PMID: 699392.
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  161. Voelkel EF, Levine L, Alper CA, Tashjian AH. Acute phase reactants ceruloplasmin and haptoglobin and their relationship to plasma prostaglandins in rabbits bearing the VS2 carcinoma. J Exp Med. 1978 Apr 01; 147(4):1078-88. PMID: 650152; PMCID: PMC2184254.
  162. Glass D, Raum D, Balavitch D, Kagan E, Rabson A, Schur PH, Alper CA. Inherited deficiency of the sixth component of complement: a silent or null gene. J Immunol. 1978 Feb; 120(2):538-41. PMID: 621392.
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  163. Davis AE, Davis JS, Rabson AR, Osofsky SG, Colten HR, Rosen FS, Alper CA. Homozygous C3 deficiency: detection of C3 by radioimmunoassay. Clin Immunol Immunopathol. 1977 Nov; 8(3):543-50. PMID: 303161.
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  164. Arnaout MA, Davis AE, Rosen RS, Alper CA. Complement activation in semisolid media: insolubilization of alternative pathway convertases in agar gels with C3 nephritic factor-containing sera. J Immunol. 1977 Oct; 119(4):1316-20. PMID: 894039.
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  165. Davis AE, Arnaout MA, Alper CA, Rosen FS. Transfer of C3 nephritic factor from mother to fetus. Is C3 nephritic factor IgG? N Engl J Med. 1977 Jul 21; 297(3):144-5. PMID: 865586.
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  166. Hall JE, Alper CA. Genetic polymorphism of the sixth component of complement (C6) in the rhesus monkey. J Immunol. 1977 Jul; 119(1):253-5. PMID: 406324.
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  167. Ochs HD, Rosenfeld SI, Thomas ED, Giblett ER, Alper CA, Dupont B, Schaller JG, Gilliland BC, Hansen JA, Wedgwood RJ. Linkage between the gene (or genes) controlling synthesis of the fourth component of complement and the major histocompatibility complex. N Engl J Med. 1977 Mar 03; 296(9):470-5. PMID: 138091.
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  168. Alper CA, Davis AE, Rosen FS. Complement and immunologic disease. Arthritis Rheum. 1977 Mar; 20(2 Suppl):449-58. PMID: 263919.
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  169. Raum D, Glass D, Carpenter CB, Alper CA, Schur PH. The chromosomal order of genes controlling the major histocompatibility complex, properdin factor B, and deficiency of the second component of complement. J Clin Invest. 1976 Nov; 58(5):1240-8. PMID: 993342; PMCID: PMC333293.
  170. Alper CA. Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf. J Exp Med. 1976 Oct 01; 144(4):1111-5. PMID: 978135; PMCID: PMC2190428.
  171. Alper CA, Balavitch D. Cobra venom factor: evidence for its being altered cobra C3 (the third component of complement). Science. 1976 Mar 26; 191(4233):1275-6. PMID: 56780.
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  172. Ziegler JB, Watson L, Goodkofsky I, Alper CA, Lepow IH. Complement activation in semi-solid medium: Insolubilization of properdin and the third component of complement (C3) in agar gels. J Immunol. 1976 Jan; 116(1):75-9. PMID: 812917.
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  173. Alper CA, Colten HR, Gear JS, Rabson AR, Rosen FS. Homozygous human C3 deficiency. The role of C3 in antibody production, C-1s-induced vasopermeability, and cobra venom-induced passive hemolysis. J Clin Invest. 1976 Jan; 57(1):222-9. PMID: 1107355; PMCID: PMC436642.
  174. Bhan AK, Grand RJ, Colten HR, Alper CA. Liver in alpha1-antitrypsin deficiency: morphologic observations and in vitro synthesis of alpha1-antitrypsin. Pediatr Res. 1976 Jan; 10(1):35-40. PMID: 1082120.
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  175. Alper CA, Rosen FS. Genetics of the complement system. Adv Hum Genet. 1976; 7:141-88. PMID: 827931.
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  176. Ziegler JB, Watson L, Alper CA. Genetic polymorphism of properdin factor B in the rhesus: evidence for single subunit structure in primates. J Immunol. 1975 Jun; 114(6):1649-53. PMID: 1127225.
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  177. Stossel TP, Field RJ, Gitlin JD, Alper CA, Rosen FS. The opsonic fragment of the third component of human complement (C3). J Exp Med. 1975 Jun 01; 141(6):1329-47. PMID: 236357; PMCID: PMC2189853.
  178. Einstein LP, Alper CA, Bloch KJ, Herrin JT, Rosen FS, David JR, Colten HR. Biosynthetic defect in monocytes from human beings with genetic deficiency of the second component of complement. N Engl J Med. 1975 May 29; 292(22):1169-71. PMID: 1124106.
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  179. Ziegler JB, Alper CA, Balner H. Properdin factor B and histocompatibility loci linked in the rhesus monkey. Nature. 1975 Apr 17; 254(5501):609-11. PMID: 48198.
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  180. Alper CA, Rosen FS. Clinical applications of complement assays. Adv Intern Med. 1975; 20:61-88. PMID: 46689.
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  181. Zucker MB, Grant RA, Alper CA, Goodkofsky I, Lepow IH. Requirement for complement components and fibrinogen in the zymosan-induced release reaction of human blood platelets. J Immunol. 1974 Dec; 113(6):1744-51. PMID: 4610046.
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  182. Schur PH, Alpert E, Alper C. Gamma G subgroups in human fetal, cord, and maternal sera. Clin Immunol Immunopathol. 1973 Nov; 2(1):62-6. PMID: 4129991.
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  183. Alper CA, Bloch KJ, Rosen FS. Increased susceptibility to infection in a patient with type II essential hypercatabolism of C3. N Engl J Med. 1973 Mar 22; 288(12):601-6. PMID: 4686987.
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  184. Stossel TP, Alper CA, Rosen FS. Serum-dependent phagocytosis of paraffin oil emulsified with bacterial lipopolysaccharide. J Exp Med. 1973 Mar 01; 137(3):690-705. PMID: 4631990; PMCID: PMC2139391.
  185. Alper CA, Goodkofsky I, Lepow IH. The relationship of glycine-rich -glycoprotein to factor B in the properdin system and to the cobra factor-binding protein of huan serum. J Exp Med. 1973 Feb 01; 137(2):424-37. PMID: 4734403; PMCID: PMC2139488.
  186. Alper CA. Genetics and the C3 molecule. Vox Sang. 1973; 25(1):1-8. PMID: 4579597.
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  187. Alper CA, Colten HR, Rosen FS, Rabson AR, Macnab GM, Gear JS. Homozygous deficiency of C3 in a patient with repeated infections. Lancet. 1972 Dec 02; 2(7788):1179-81. PMID: 4117597.
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  188. Colten HR, Alper CA. Hemolytic efficiencies of genetic variants of human C3. J Immunol. 1972 May; 108(5):1184-7. PMID: 5029137.
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  189. Refetoff S, Robin NI, Alper CA. Study of four new kindreds with inherited thyroxine-binding globulin abnormalities. Possible mutations of a single gene locus. J Clin Invest. 1972 Apr; 51(4):848-67. PMID: 4111366; PMCID: PMC302199.
  190. Alper CA, Boenisch T, Watson L. Genetic polymorphism in human glycine-rich beta-glycoprotein. J Exp Med. 1972 Jan; 135(1):68-80. PMID: 4109808; PMCID: PMC2139116.
  191. Abramson N, Alper CA, Lachmann PJ, Rosen FS, Jandl JH. Deficiency of C3 inactivator in man. J Immunol. 1971 Jul; 107(1):19-27. PMID: 4997111.
    View in: PubMed
  192. Alper CA, Robin NI, Refetoff S. Genetic polymorphism in rhesus C3 and Gc globulin. J Immunol. 1971 Jul; 107(1):96-8. PMID: 4103922.
    View in: PubMed
  193. Alper CA, Rosen FS. Genetic aspects of the complement system. Adv Immunol. 1971; 14:251-90. PMID: 5003195.
    View in: PubMed
  194. Johnson AM, Alper CA. Deficiency of alpha-antitrypsin in childhood liver disease. Pediatrics. 1970 Dec; 46(6):921-5. PMID: 5491445.
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  195. Alper CA, Johnson AM. Alpha-1-antitrypsin deficiency and disease. Pediatrics. 1970 Dec; 46(6):837-40. PMID: 4923511.
    View in: PubMed
  196. Schur PH, Borel H, Gelfand EW, Alper CA, Rosen FS. Selective gamma-g globulin deficiencies in patients with recurrent pyogenic infections. N Engl J Med. 1970 Sep 17; 283(12):631-4. PMID: 4194865.
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  197. Altay C, Alper CA, Nathan DG. Normal and variant isoenzymes of human blood cell hexokinase and the isoenzyme patterns in hemolytic anemia. Blood. 1970 Aug; 36(2):219-27. PMID: 5427456.
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  198. Johnson AM, Schmid K, Alper CA. Inheritance of human alpha-1-acid glycoprotein (orosomucoid) variants. J Clin Invest. 1969 Dec; 48(12):2293-9. PMID: 4982230; PMCID: PMC297486.
  199. Propp RP, Alper CA. Rabbit C3 isolation and characterization of reactions in vitro and during in vivo antigen-antibody interaction. Immunology. 1969 Nov; 17(5):695-707. PMID: 5352752; PMCID: PMC1455916.
  200. Johnston RB, Klemperer MR, Alper CA, Rosen FS. The enhancement of bacterial phagocytosis by serum. The role of complement components and two cofactors. J Exp Med. 1969 Jun 01; 129(6):1275-90. PMID: 4181833; PMCID: PMC2138658.
  201. Alper CA, Propp RP. Genetic polymorphism of the third component of human complement (C'3). J Clin Invest. 1968 Sep; 47(9):2181-91. PMID: 5675433; PMCID: PMC297379.
  202. Alper CA, Rosen FS. Alper CA, Rosen FS: Studies of the in vivo behavior of human C'3 in normal subjects and patients. J Clin Invest. 1967 Dec; 46(12):2021-34. PMID: 6074005; PMCID: PMC292954.
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