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Claudio Hetz, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gerakis Y, Hetz C. Brain organoids: a next step for humanized Alzheimer's disease models? Mol Psychiatry. 2019 Jan 07. PMID: 30617271.
    Citations:    Fields:    
  2. Medinas DB, Cabral-Miranda F, Hetz C. ER stress links aging to sporadic ALS. Aging (Albany NY). 2019 Jan 05; 11(1):5-6. PMID: 30612121.
    Citations:    Fields:    
  3. Groenendyk J, Paskevicius T, Urra H, Viricel C, Wang K, Barakat K, Hetz C, Kurgan L, Agellon LB, Michalak M. Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1a unfolded protein response sensor. Sci Rep. 2018 Nov 12; 8(1):16678. PMID: 30420769.
    Citations:    Fields:    
  4. García-González P, Cabral-Miranda F, Hetz C, Osorio F. Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases. Front Immunol. 2018; 9:2541. PMID: 30450103.
    Citations:    
  5. Urra H, Henriquez DR, Cánovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic Á, Gonzalez-Billault C, Hetz C. Publisher Correction: IRE1a governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A. Nat Cell Biol. 2018 Oct; 20(10):1228. PMID: 30089843.
    Citations:    Fields:    
  6. Medinas DB, Rozas P, Martínez Traub F, Woehlbier U, Brown RH, Bosco DA, Hetz C. Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2018 08 07; 115(32):8209-8214. PMID: 30038021.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Mercado G, López N, Martínez A, Sardi SP, Hetz C. A new model to study cell-to-cell transfer of aSynuclein in vivo. Biochem Biophys Res Commun. 2018 09 10; 503(3):1385-1393. PMID: 30025892.
    Citations:    Fields:    
  8. Urra H, Henriquez DR, Cánovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic Á, Gonzalez-Billault C, Hetz C. IRE1a governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A. Nat Cell Biol. 2018 Aug; 20(8):942-953. PMID: 30013108.
    Citations:    Fields:    
  9. Lebeaupin C, Vallée D, Hazari Y, Hetz C, Chevet E, Bailly-Maitre B. Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease. J Hepatol. 2018 Oct; 69(4):927-947. PMID: 29940269.
    Citations: 2     Fields:    
  10. Martínez G, Khatiwada S, Costa-Mattioli M, Hetz C. ER Proteostasis Control of Neuronal Physiology and Synaptic Function. Trends Neurosci. 2018 09; 41(9):610-624. PMID: 29945734.
    Citations: 1     Fields:    
  11. Rojas-Rivera D, Rodriguez DA, Sepulveda D, Hetz C. ER stress sensing mechanism: Putting off the brake on UPR transducers. Oncotarget. 2018 Apr 13; 9(28):19461-19462. PMID: 29731957.
    Citations:    Fields:    
  12. Valenzuela V, Jackson KL, Sardi SP, Hetz C. Gene Therapy Strategies to Restore ER Proteostasis in Disease. Mol Ther. 2018 06 06; 26(6):1404-1413. PMID: 29728295.
    Citations: 1     Fields:    
  13. Valenzuela V, Nassif M, Hetz C. Unraveling the role of motoneuron autophagy in ALS. Autophagy. 2018; 14(4):733-737. PMID: 29388464.
    Citations:    Fields:    
  14. Lhomond S, Avril T, Dejeans N, Voutetakis K, Doultsinos D, McMahon M, Pineau R, Obacz J, Papadodima O, Jouan F, Bourien H, Logotheti M, Jégou G, Pallares-Lupon N, Schmit K, Le Reste PJ, Etcheverry A, Mosser J, Barroso K, Vauléon E, Maurel M, Samali A, Patterson JB, Pluquet O, Hetz C, Quillien V, Chatziioannou A, Chevet E. Dual IRE1 RNase functions dictate glioblastoma development. EMBO Mol Med. 2018 03; 10(3). PMID: 29311133.
    Citations: 3     Fields:    
  15. González-Quiroz M, Urra H, Limia CM, Hetz C. Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases. Semin Cancer Biol. 2018 06; 50:42-52. PMID: 29369790.
    Citations:    Fields:    Translation:HumansCells
  16. Mercado G, Castillo V, Soto P, López N, Axten JM, Sardi SP, Hoozemans JJM, Hetz C. Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease. Neurobiol Dis. 2018 Apr; 112:136-148. PMID: 29355603.
    Citations: 3     Fields:    
  17. Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 Mar; 25(3):486-541. PMID: 29362479.
    Citations: 40     Fields:    
  18. Sepulveda D, Rojas-Rivera D, Rodríguez DA, Groenendyk J, Köhler A, Lebeaupin C, Ito S, Urra H, Carreras-Sureda A, Hazari Y, Vasseur-Cognet M, Ali MMU, Chevet E, Campos G, Godoy P, Vaisar T, Bailly-Maitre B, Nagata K, Michalak M, Sierralta J, Hetz C. Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1a. Mol Cell. 2018 01 18; 69(2):238-252.e7. PMID: 29351844.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  19. Cabral-Miranda F, Hetz C. ER Stress and Neurodegenerative Disease: A Cause or Effect Relationship? Curr Top Microbiol Immunol. 2018; 414:131-157. PMID: 28864830.
    Citations: 1     Fields:    Translation:HumansAnimals
  20. Matamala JM, Arias-Carrasco R, Sanchez C, Uhrig M, Bargsted L, Matus S, Maracaja-Coutinho V, Abarzua S, van Zundert B, Verdugo R, Manque P, Hetz C. Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis. Neurobiol Aging. 2018 04; 64:123-138. PMID: 29458840.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  21. Pérez-Arancibia R, Rivas A, Hetz C. (off)Targeting UPR signaling: the race toward intervening ER proteostasis. Expert Opin Ther Targets. 2018 02; 22(2):97-100. PMID: 29260915.
    Citations:    Fields:    Translation:HumansAnimalsCells
  22. Gerakis Y, Hetz C. Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease. FEBS J. 2018 03; 285(6):995-1011. PMID: 29148236.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  23. Hetz C, Papa FR. The Unfolded Protein Response and Cell Fate Control. Mol Cell. 2018 01 18; 69(2):169-181. PMID: 29107536.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  24. Bargsted L, Medinas DB, Martínez Traub F, Rozas P, Muñoz N, Nassif M, Jerez C, Catenaccio A, Court FA, Hetz C, Matus S. Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model. Sci Rep. 2017 Oct 27; 7(1):14266. PMID: 29079747.
    Citations: 2     Fields:    
  25. Urra H, Hetz C. Fine-tuning PERK signaling to control cell fate under stress. Nat Struct Mol Biol. 2017 Oct 05; 24(10):789-790. PMID: 28981072.
    Citations: 1     Fields:    
  26. Medinas DB, Valenzuela V, Hetz C. Proteostasis disturbance in amyotrophic lateral sclerosis. Hum Mol Genet. 2017 10 01; 26(R2):R91-R104. PMID: 28977445.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  27. Gerakis Y, Hetz C. A decay of the adaptive capacity of the unfolded protein response exacerbates Alzheimer's disease. Neurobiol Aging. 2018 03; 63:162-164. PMID: 29042130.
    Citations:    Fields:    Translation:HumansCells
  28. Carreras-Sureda A, Pihán P, Hetz C. Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses. Cell Calcium. 2018 03; 70:24-31. PMID: 29054537.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  29. Hetz C, Saxena S. ER stress and the unfolded protein response in neurodegeneration. Nat Rev Neurol. 2017 Aug; 13(8):477-491. PMID: 28731040.
    Citations: 25     Fields:    
  30. Medinas DB, González JV, Falcon P, Hetz C. Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis. Front Mol Neurosci. 2017; 10:216. PMID: 28725179.
    Citations:    
  31. Pihán P, Carreras-Sureda A, Hetz C. BCL-2 family: integrating stress responses at the ER to control cell demise. Cell Death Differ. 2017 09; 24(9):1478-1487. PMID: 28622296.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  32. Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C. BAX inhibitor-1 regulates autophagy by controlling the IRE1a branch of the unfolded protein response. EMBO J. 2017 06 01; 36(11):1640. PMID: 28572284.
    Citations:    Fields:    
  33. Mercado G, Hetz C. Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts. Brain. 2017 Jun 01; 140(6):1544-1547. PMID: 28549133.
    Citations: 1     Fields:    
  34. Martínez G, Duran-Aniotz C, Cabral-Miranda F, Vivar JP, Hetz C. Endoplasmic reticulum proteostasis impairment in aging. Aging Cell. 2017 08; 16(4):615-623. PMID: 28436203.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  35. Carreras-Sureda A, Pihán P, Hetz C. The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics. Front Oncol. 2017; 7:55. PMID: 28421160.
    Citations: 5     
  36. Duran-Aniotz C, Cornejo VH, Espinoza S, Ardiles ÁO, Medinas DB, Salazar C, Foley A, Gajardo I, Thielen P, Iwawaki T, Scheper W, Soto C, Palacios AG, Hoozemans JJM, Hetz C. IRE1 signaling exacerbates Alzheimer's disease pathogenesis. Acta Neuropathol. 2017 Sep; 134(3):489-506. PMID: 28341998.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  37. Park KW, Eun Kim G, Morales R, Moda F, Moreno-Gonzalez I, Concha-Marambio L, Lee AS, Hetz C, Soto C. The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo. Sci Rep. 2017 03 23; 7:44723. PMID: 28333162.
    Citations: 6     Fields:    Translation:AnimalsCells
  38. Obacz J, Avril T, Le Reste PJ, Urra H, Quillien V, Hetz C, Chevet E. Endoplasmic reticulum proteostasis in glioblastoma-From molecular mechanisms to therapeutic perspectives. Sci Signal. 2017 Mar 14; 10(470). PMID: 28292956.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  39. González AE, Muñoz VC, Cavieres VA, Bustamante HA, Cornejo VH, Januário YC, González I, Hetz C, daSilva LL, Rojas-Fernández A, Hay RT, Mardones GA, Burgos PV. Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway. FASEB J. 2017 06; 31(6):2446-2459. PMID: 28254759.
    Citations: 2     Fields:    Translation:HumansCells
  40. Guerrero N, Meynard MM, Borgonovo J, Palma K, Concha ML, Hetz C. Prion Function and Pathophysiology in Non-Mammalian Models. Curr Mol Med. 2017; 17(1):13-23. PMID: 28231753.
    Citations:    Fields:    Translation:HumansAnimals
  41. Castillo K, Valenzuela V, Oñate M, Hetz C. A Molecular Reporter for Monitoring Autophagic Flux in Nervous System In Vivo. Methods Enzymol. 2017; 588:109-131. PMID: 28237096.
    Citations:    Fields:    Translation:HumansAnimalsCells
  42. Hetz C, Saxena S. PREFACE: Divergent roles of ER stress in neurodegeneration and brain disorders. Brain Res. 2016 10 01; 1648(Pt B):527-529. PMID: 27667747.
    Citations:    Fields:    Translation:HumansAnimalsCells
  43. Duran-Aniotz C, Hetz C. Glucose Metabolism: A Sweet Relief of Alzheimer's Disease. Curr Biol. 2016 09 12; 26(17):R806-9. PMID: 27623263.
    Citations: 1     Fields:    Translation:HumansCells
  44. Xiang M, Kim H, Ho VT, Walker SR, Bar-Natan M, Anahtar M, Liu S, Toniolo PA, Kroll Y, Jones N, Giaccone ZT, Heppler LN, Ye DQ, Marineau JJ, Shaw D, Bradner JE, Blonquist T, Neuberg D, Hetz C, Stone RM, Soiffer RJ, Frank DA. Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent. Blood. 2016 10 06; 128(14):1845-1853. PMID: 27531676.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  45. Martínez G, Duran-Aniotz C, Cabral-Miranda F, Hetz C. Commentary: XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity. Front Aging Neurosci. 2016; 8:182. PMID: 27534903; PMCID: PMC4971125.
    Citations: 2     
  46. Ramírez M, Gallardo A, Vidal A, Cornejo S, Ramírez D, Medinas D, Bustamante G, Pasquali R, Hetz C. [Creutzfeldt-Jakob disease: Report of one case]. Rev Med Chil. 2016 Jun; 144(6):796-806. PMID: 27598501.
    Citations:    Fields:    Translation:Humans
  47. Oñate M, Court FA, Hetz C. Bursting the unfolded protein response accelerates axonal regeneration. Neural Regen Res. 2016 Jun; 11(6):892-3. PMID: 27482204; PMCID: PMC4962573.
    Citations:    
  48. Rozas P, Bargsted L, Martínez F, Hetz C, Medinas DB. The ER proteostasis network in ALS: Determining the differential motoneuron vulnerability. Neurosci Lett. 2017 01 01; 636:9-15. PMID: 27150076.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  49. Valenzuela V, Martínez G, Duran-Aniotz C, Hetz C. Gene therapy to target ER stress in brain diseases. Brain Res. 2016 10 01; 1648(Pt B):561-570. PMID: 27131987.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  50. Valenzuela V, Oñate M, Hetz C, Court FA. Injury to the nervous system: A look into the ER. Brain Res. 2016 10 01; 1648(Pt B):617-625. PMID: 27117870.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  51. Urra H, Dufey E, Avril T, Chevet E, Hetz C. Endoplasmic Reticulum Stress and the Hallmarks of Cancer. Trends Cancer. 2016 05; 2(5):252-262. PMID: 28741511.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  52. Nivon M, Fort L, Muller P, Richet E, Simon S, Guey B, Fournier M, Arrigo AP, Hetz C, Atkin JD, Kretz-Remy C. NF?B is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation. Mol Biol Cell. 2016 06 01; 27(11):1712-27. PMID: 27075172; PMCID: PMC4884063.
    Citations: 3     Fields:    Translation:HumansCells
  53. Garcia-Huerta P, Troncoso-Escudero P, Jerez C, Hetz C, Vidal RL. The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases? Brain Res. 2016 Oct 15; 1649(Pt B):173-180. PMID: 26993573.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  54. Mollereau B, Rzechorzek NM, Roussel BD, Sedru M, Van den Brink DM, Bailly-Maitre B, Palladino F, Medinas DB, Domingos PM, Hunot S, Chandran S, Birman S, Baron T, Vivien D, Duarte CB, Ryoo HD, Steller H, Urano F, Chevet E, Kroemer G, Ciechanover A, Calabrese EJ, Kaufman RJ, Hetz C. Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations. Brain Res. 2016 10 01; 1648(Pt B):603-616. PMID: 26923166.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  55. Duran-Aniotz C, Cornejo VH, Hetz C. Targeting endoplasmic reticulum acetylation to restore proteostasis in Alzheimer's disease. Brain. 2016 Mar; 139(Pt 3):650-2. PMID: 26917585.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  56. Oñate M, Catenaccio A, Martínez G, Armentano D, Parsons G, Kerr B, Hetz C, Court FA. Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury. Sci Rep. 2016 Feb 24; 6:21709. PMID: 26906090; PMCID: PMC4764858.
    Citations: 14     Fields:    Translation:AnimalsCells
  57. Mardones P, Rubinsztein DC, Hetz C. Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport. Sci Signal. 2016 Feb 23; 9(416):fs2. PMID: 26905424.
    Citations: 8     Fields:    Translation:HumansAnimals
  58. Woehlbier U, Colombo A, Saaranen MJ, Pérez V, Ojeda J, Bustos FJ, Andreu CI, Torres M, Valenzuela V, Medinas DB, Rozas P, Vidal RL, Lopez-Gonzalez R, Salameh J, Fernandez-Collemann S, Muñoz N, Matus S, Armisen R, Sagredo A, Palma K, Irrazabal T, Almeida S, Gonzalez-Perez P, Campero M, Gao FB, Henny P, van Zundert B, Ruddock LW, Concha ML, Henriquez JP, Brown RH, Hetz C. ALS-linked protein disulfide isomerase variants cause motor dysfunction. EMBO J. 2016 Apr 15; 35(8):845-65. PMID: 26869642; PMCID: PMC4972141.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  59. Martínez G, Vidal RL, Mardones P, Serrano FG, Ardiles AO, Wirth C, Valdés P, Thielen P, Schneider BL, Kerr B, Valdés JL, Palacios AG, Inestrosa NC, Glimcher LH, Hetz C. Regulation of Memory Formation by the Transcription Factor XBP1. Cell Rep. 2016 Feb 16; 14(6):1382-1394. PMID: 26854229.
    Citations: 25     Fields:    Translation:AnimalsCells
  60. Bargsted L, Hetz C, Matus S. ERp57 in neurodegeneration and regeneration. Neural Regen Res. 2016 Feb; 11(2):232-3. PMID: 27073369; PMCID: PMC4810980.
    Citations: 1     
  61. Sepulveda M, Rozas P, Hetz C, Medinas DB. ERp57 as a novel cellular factor controlling prion protein biosynthesis: Therapeutic potential of protein disulfide isomerases. Prion. 2016; 10(1):50-6. PMID: 26864548; PMCID: PMC4981197.
    Citations:    Fields:    Translation:HumansCells
  62. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
    Citations: 867     Fields:    Translation:HumansAnimals
  63. Gupta A, Hossain MM, Read DE, Hetz C, Samali A, Gupta S. PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response. Sci Rep. 2015 Dec 17; 5:18304. PMID: 26674075; PMCID: PMC4682135.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  64. Mardones P, Hetz C. Peroxisomes Get Loud: A Redox Antidote to Hearing Loss. Cell. 2015 Nov 05; 163(4):790-1. PMID: 26544930.
    Citations:    Fields:    Translation:HumansAnimalsCells
  65. Castillo V, Oñate M, Woehlbier U, Rozas P, Andreu C, Medinas D, Valdés P, Osorio F, Mercado G, Vidal RL, Kerr B, Court FA, Hetz C. Correction: Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration. PLoS One. 2015; 10(10):e0140200. PMID: 26431197; PMCID: PMC4591992.
    Citations: 1     Fields:    
  66. Castillo V, Oñate M, Woehlbier U, Rozas P, Andreu C, Medinas D, Valdés P, Osorio F, Mercado G, Vidal RL, Kerr B, Court FA, Hetz C. Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration. PLoS One. 2015; 10(9):e0136620. PMID: 26361352; PMCID: PMC4567344.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  67. Hetz C, Chevet E, Oakes SA. Erratum: Proteostasis control by the unfolded protein response. Nat Cell Biol. 2015 Aug; 17(8):1088. PMID: 26239530.
    Citations:    Fields:    
  68. Rivas A, Vidal RL, Hetz C. Targeting the unfolded protein response for disease intervention. Expert Opin Ther Targets. 2015; 19(9):1203-18. PMID: 26166159.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  69. Torres M, Medinas DB, Matamala JM, Woehlbier U, Cornejo VH, Solda T, Andreu C, Rozas P, Matus S, Muñoz N, Vergara C, Cartier L, Soto C, Molinari M, Hetz C. The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein. J Biol Chem. 2015 Sep 25; 290(39):23631-45. PMID: 26170458; PMCID: PMC4583042.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  70. Castillo V, Mercado G, Hetz C. Gene therapy in Parkinson's disease: targeting the endplasmic reticulum proteostasis network. Neural Regen Res. 2015 Jul; 10(7):1053-4. PMID: 26330821; PMCID: PMC4541229.
    Citations: 3     
  71. Hetz C, Chevet E, Oakes SA. Proteostasis control by the unfolded protein response. Nat Cell Biol. 2015 Jul; 17(7):829-38. PMID: 26123108.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  72. Chevet E, Hetz C, Samali A. Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis. Cancer Discov. 2015 Jun; 5(6):586-97. PMID: 25977222.
    Citations: 55     Fields:    Translation:HumansCells
  73. Garcia-Huerta P, Rivas A, Hetz C. Stressing out the ER in aminoglycoside-induced hearing loss. Cell Death Dis. 2015 May 14; 6:e1762. PMID: 25973682; PMCID: PMC4669711.
    Citations:    Fields:    Translation:HumansAnimals
  74. Hetz C, Chevet E. Theme Series--UPR in cancer. Semin Cancer Biol. 2015 Aug; 33:1-2. PMID: 25957480.
    Citations: 1     Fields:    Translation:HumansCells
  75. Dufey E, Urra H, Hetz C. ER proteostasis addiction in cancer biology: Novel concepts. Semin Cancer Biol. 2015 Aug; 33:40-7. PMID: 25931388.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  76. Gonzalez-Perez P, Woehlbier U, Chian RJ, Sapp P, Rouleau GA, Leblond CS, Daoud H, Dion PA, Landers JE, Hetz C, Brown RH. Identification of rare protein disulfide isomerase gene variants in amyotrophic lateral sclerosis patients. Gene. 2015 Jul 25; 566(2):158-65. PMID: 25913742.
    Citations: 14     Fields:    Translation:HumansCells
  77. Mercado G, Castillo V, Vidal R, Hetz C. ER proteostasis disturbances in Parkinson's disease: novel insights. Front Aging Neurosci. 2015; 7:39. PMID: 25870559; PMCID: PMC4376001.
    Citations: 7     
  78. Carreras-Sureda A, Hetz C. RNA metabolism: putting the brake on the UPR. EMBO Rep. 2015 May; 16(5):545-6. PMID: 25807987; PMCID: PMC4428039.
    Citations: 2     Fields:    Translation:AnimalsCells
  79. Torres M, Matamala JM, Duran-Aniotz C, Cornejo VH, Foley A, Hetz C. ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related disorders. Virus Res. 2015 Sep 02; 207:69-75. PMID: 25556124.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  80. Medinas DB, Hetz C. Protein homeostasis: Modeling UPR adaptive responses. Nat Chem Biol. 2014 Nov; 10(11):879-80. PMID: 25325696.
    Citations: 1     Fields:    Translation:HumansCells
  81. Matus S, Bosco DA, Hetz C. Autophagy meets fused in sarcoma-positive stress granules. Neurobiol Aging. 2014 Dec; 35(12):2832-2835. PMID: 25444610; PMCID: PMC4324442.
    Citations: 2     Fields:    Translation:HumansCells
  82. Vidal RL, Matus S, Bargsted L, Hetz C. Targeting autophagy in neurodegenerative diseases. Trends Pharmacol Sci. 2014 Nov; 35(11):583-91. PMID: 25270767.
    Citations: 26     Fields:    Translation:HumansAnimals
  83. Couve A, Hetz C. RESETing ER proteostasis: selective stress pathway hidden in the secretory route. EMBO J. 2014 Nov 03; 33(21):2444-6. PMID: 25190517; PMCID: PMC4283403.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  84. Mardones P, Dillin A, Hetz C. Cell-nonautonomous control of the UPR: mastering energy homeostasis. Cell Metab. 2014 Sep 02; 20(3):385-7. PMID: 25185942.
    Citations: 2     Fields:    Translation:AnimalsCells
  85. Mardones P, Martínez G, Hetz C. Control of systemic proteostasis by the nervous system. Trends Cell Biol. 2015 Jan; 25(1):1-10. PMID: 25174273.
    Citations: 14     Fields:    Translation:AnimalsCells
  86. Dufey E, Sepúlveda D, Rojas-Rivera D, Hetz C. Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 1. An overview. Am J Physiol Cell Physiol. 2014 Oct 01; 307(7):C582-94. PMID: 25143348.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  87. Groenendyk J, Hetz C, Kurgan L, Michalak M. P125Endoplasmic reticulum stress responses to disrupted endoplasmic reticulum ca2+ homeostasis. Cardiovasc Res. 2014 Jul 15; 103 Suppl 1:S22. PMID: 25020546.
    Citations:    
  88. Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim DH, Baretta K, Srikanth S, Gwack Y, Ahnn J, Kaufman RJ, Lee SK, Hetz C, Kurgan L, Michalak M. Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. Sci Signal. 2014 Jun 10; 7(329):ra54. PMID: 24917591; PMCID: PMC4984425.
    Citations: 13     Fields:    Translation:AnimalsCells
  89. Matus S, Medinas DB, Hetz C. Common ground: stem cell approaches find shared pathways underlying ALS. Cell Stem Cell. 2014 Jun 05; 14(6):697-9. PMID: 24905158.
    Citations: 8     Fields:    
  90. Urra H, Hetz C. A novel ER stress-independent function of the UPR in angiogenesis. Mol Cell. 2014 May 22; 54(4):542-4. PMID: 24856218.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  91. Nassif M, Valenzuela V, Rojas-Rivera D, Vidal R, Matus S, Castillo K, Fuentealba Y, Kroemer G, Levine B, Hetz C. Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis. Autophagy. 2014 Jul; 10(7):1256-71. PMID: 24905722; PMCID: PMC4203551.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  92. Valdés P, Mercado G, Vidal RL, Molina C, Parsons G, Court FA, Martinez A, Galleguillos D, Armentano D, Schneider BL, Hetz C. Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1. Proc Natl Acad Sci U S A. 2014 May 06; 111(18):6804-9. PMID: 24753614; PMCID: PMC4020088.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  93. Campos G, Schmidt-Heck W, Ghallab A, Rochlitz K, Pütter L, Medinas DB, Hetz C, Widera A, Cadenas C, Begher-Tibbe B, Reif R, Günther G, Sachinidis A, Hengstler JG, Godoy P. The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity. Arch Toxicol. 2014 Jun; 88(6):1267-80. PMID: 24748426.
    Citations: 9     Fields:    Translation:AnimalsCells
  94. Matus S, Valenzuela V, Hetz C. A new method to measure autophagy flux in the nervous system. Autophagy. 2014 Apr; 10(4):710-4. PMID: 24717689; PMCID: PMC4091163.
    Citations: 4     Fields:    Translation:AnimalsCells
  95. Hetz C, Mollereau B. Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases. Nat Rev Neurosci. 2014 Apr; 15(4):233-49. PMID: 24619348.
    Citations: 159     Fields:    Translation:HumansAnimalsCells
  96. Rojas-Rivera D, Hetz C. TMBIM protein family: ancestral regulators of cell death. Oncogene. 2015 Jan 15; 34(3):269-80. PMID: 24561528.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  97. Duran-Aniotz C, Martínez G, Hetz C. Memory loss in Alzheimer's disease: are the alterations in the UPR network involved in the cognitive impairment? Front Aging Neurosci. 2014; 6:8. PMID: 24523695; PMCID: PMC3906588.
    Citations: 5     
  98. Dejeans N, Manié S, Hetz C, Bard F, Hupp T, Agostinis P, Samali A, Chevet E. Addicted to secrete - novel concepts and targets in cancer therapy. Trends Mol Med. 2014 May; 20(5):242-50. PMID: 24456621.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  99. Medinas DB, Hetz C. Proteostasis impairment: at the intersection between Alzheimer's disease and diabetes. Cell Metab. 2013 Dec 03; 18(6):771-2. PMID: 24315366.
    Citations: 4     Fields:    Translation:Animals
  100. Castillo K, Valenzuela V, Matus S, Nassif M, Oñate M, Fuentealba Y, Encina G, Irrazabal T, Parsons G, Court FA, Schneider BL, Armentano D, Hetz C. Measurement of autophagy flux in the nervous system in vivo. Cell Death Dis. 2013 Nov 14; 4:e917. PMID: 24232093; PMCID: PMC3847309.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  101. Cornejo VH, Pihán P, Vidal RL, Hetz C. Role of the unfolded protein response in organ physiology: lessons from mouse models. IUBMB Life. 2013 Dec; 65(12):962-75. PMID: 24227223.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  102. Matus S, Valenzuela V, Medinas DB, Hetz C. ER Dysfunction and Protein Folding Stress in ALS. Int J Cell Biol. 2013; 2013:674751. PMID: 24324498; PMCID: PMC3845333.
    Citations: 27     
  103. Quiroga C, Gatica D, Paredes F, Bravo R, Troncoso R, Pedrozo Z, Rodriguez AE, Toro B, Chiong M, Vicencio JM, Hetz C, Lavandero S. Herp depletion protects from protein aggregation by up-regulating autophagy. Biochim Biophys Acta. 2013 Dec; 1833(12):3295-3305. PMID: 24120520.
    Citations: 6     Fields:    Translation:AnimalsCells
  104. Hetz C, Chevet E, Harding HP. Targeting the unfolded protein response in disease. Nat Rev Drug Discov. 2013 Sep; 12(9):703-19. PMID: 23989796.
    Citations: 211     Fields:    Translation:HumansAnimalsCells
  105. Urra H, Dufey E, Lisbona F, Rojas-Rivera D, Hetz C. When ER stress reaches a dead end. Biochim Biophys Acta. 2013 Dec; 1833(12):3507-3517. PMID: 23988738.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  106. Matus S, Lopez E, Valenzuela V, Nassif M, Hetz C. Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis. PLoS One. 2013; 8(7):e66672. PMID: 23874395; PMCID: PMC3715499.
    Citations: 20     Fields:    Translation:AnimalsCells
  107. Kiviluoto S, Luyten T, Schneider L, Lisak D, Rojas-Rivera D, Welkenhuyzen K, Missaen L, De Smedt H, Parys JB, Hetz C, Methner A, Bultynck G. Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis. Cell Calcium. 2013 Sep; 54(3):186-92. PMID: 23867001.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  108. Hetz C. The biological meaning of the UPR. Nat Rev Mol Cell Biol. 2013 Jul; 14(7):404. PMID: 23756618.
    Citations:    
  109. Castillo K, Nassif M, Valenzuela V, Rojas F, Matus S, Mercado G, Court FA, van Zundert B, Hetz C. Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Autophagy. 2013 Sep; 9(9):1308-20. PMID: 23851366.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  110. Cornejo VH, Hetz C. The unfolded protein response in Alzheimer's disease. Semin Immunopathol. 2013 May; 35(3):277-92. PMID: 23609500.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  111. Smaili SS, Quest AF, Hetz C, Lavandero S. Editorial: signaling in cell death, survival, proliferation and degeneration. Curr Mol Med. 2013 Feb; 13(2):239-40. PMID: 23228126.
    Citations:    Fields:    Translation:HumansCells
  112. Mercado G, Valdés P, Hetz C. An ERcentric view of Parkinson's disease. Trends Mol Med. 2013 Mar; 19(3):165-75. PMID: 23352769.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  113. Vidal RL, Hetz C. Unspliced XBP1 controls autophagy through FoxO1. Cell Res. 2013 Apr; 23(4):463-4. PMID: 23337584; PMCID: PMC3616432.
    Citations: 6     Fields:    Translation:Humans
  114. Acuña AI, Esparza M, Kramm C, Beltrán FA, Parra AV, Cepeda C, Toro CA, Vidal RL, Hetz C, Concha II, Brauchi S, Levine MS, Castro MA. A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington's disease in mice. Nat Commun. 2013; 4:2917. PMID: 24336051; PMCID: PMC3905737.
    Citations: 16     Fields:    Translation:AnimalsCells
  115. Urra H, Hetz C. The ER in 4D: a novel stress pathway controlling endoplasmic reticulum membrane remodeling. Cell Death Differ. 2012 Dec; 19(12):1893-5. PMID: 23147678; PMCID: PMC3504704.
    Citations: 3     Fields:    Translation:HumansCells
  116. Nassif M, Hetz C. Autophagy impairment: a crossroad between neurodegeneration and tauopathies. BMC Biol. 2012 Sep 21; 10:78. PMID: 22999309; PMCID: PMC3448508.
    Citations: 7     Fields:    Translation:HumansAnimals
  117. Martínez G, Hetz C. Cell-nonautonomous control of the UPR. EMBO Rep. 2012 Sep; 13(9):767-8. PMID: 22868667; PMCID: PMC3432808.
    Citations: 2     Fields:    Translation:AnimalsCells
  118. Andreu CI, Woehlbier U, Torres M, Hetz C. Protein disulfide isomerases in neurodegeneration: from disease mechanisms to biomedical applications. FEBS Lett. 2012 Aug 31; 586(18):2826-34. PMID: 22828277.
    Citations: 30     Fields:    Translation:Cells
  119. Gupta S, Read DE, Deepti A, Cawley K, Gupta A, Oommen D, Verfaillie T, Matus S, Smith MA, Mott JL, Agostinis P, Hetz C, Samali A. Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis. Cell Death Dis. 2012 Jun 28; 3:e333. PMID: 22739985; PMCID: PMC3388242.
    Citations: 38     Fields:    Translation:AnimalsCells
  120. Zamorano S, Rojas-Rivera D, Lisbona F, Parra V, Court FA, Villegas R, Cheng EH, Korsmeyer SJ, Lavandero S, Hetz C. A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway. PLoS One. 2012; 7(6):e37782. PMID: 22719850; PMCID: PMC3373601.
    Citations: 7     Fields:    Translation:AnimalsCells
  121. Matus S, Castillo K, Hetz C. Hormesis: protecting neurons against cellular stress in Parkinson disease. Autophagy. 2012 Jun; 8(6):997-1001. PMID: 22858553; PMCID: PMC3427272.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  122. Vidal RL, Hetz C. Crosstalk between the UPR and autophagy pathway contributes to handling cellular stress in neurodegenerative disease. Autophagy. 2012 Jun; 8(6):970-2. PMID: 22617512; PMCID: PMC3427262.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  123. Torres M, Cartier L, Matamala JM, Hernández N, Woehlbier U, Hetz C. Altered Prion protein expression pattern in CSF as a biomarker for Creutzfeldt-Jakob disease. PLoS One. 2012; 7(4):e36159. PMID: 22558368; PMCID: PMC3338608.
    Citations: 11     Fields:    Translation:HumansCells
  124. Rodriguez DA, Zamorano S, Lisbona F, Rojas-Rivera D, Urra H, Cubillos-Ruiz JR, Armisen R, Henriquez DR, Cheng EH, Letek M, Vaisar T, Irrazabal T, Gonzalez-Billault C, Letai A, Pimentel-Muiños FX, Kroemer G, Hetz C. BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1a. EMBO J. 2012 May 16; 31(10):2322-35. PMID: 22510886; PMCID: PMC3364744.
    Citations: 33     Fields:    Translation:AnimalsCells
  125. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490.
    Citations: 1363     Fields:    Translation:HumansAnimals
  126. Herrera-Molina R, Frischknecht R, Maldonado H, Seidenbecher CI, Gundelfinger ED, Hetz C, Aylwin Mde L, Schneider P, Quest AF, Leyton L. Astrocytic aVß3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering Thy-1. PLoS One. 2012; 7(3):e34295. PMID: 22479590; PMCID: PMC3316703.
    Citations: 14     Fields:    Translation:AnimalsCells
  127. Zuleta A, Vidal RL, Armentano D, Parsons G, Hetz C. AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease. Biochem Biophys Res Commun. 2012 Apr 13; 420(3):558-63. PMID: 22445760.
    Citations: 22     Fields:    Translation:AnimalsCells
  128. Valenzuela V, Collyer E, Armentano D, Parsons GB, Court FA, Hetz C. Activation of the unfolded protein response enhances motor recovery after spinal cord injury. Cell Death Dis. 2012 Feb 16; 3:e272. PMID: 22337234; PMCID: PMC3288350.
    Citations: 42     Fields:    Translation:AnimalsCells
  129. Vidal RL, Figueroa A, Court FA, Thielen P, Molina C, Wirth C, Caballero B, Kiffin R, Segura-Aguilar J, Cuervo AM, Glimcher LH, Hetz C. Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy. Hum Mol Genet. 2012 May 15; 21(10):2245-62. PMID: 22337954; PMCID: PMC3335312.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  130. Hetz C. The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol. 2012 Jan 18; 13(2):89-102. PMID: 22251901.
    Citations: 671     Fields:    Translation:HumansAnimalsCells
  131. Rojas-Rivera D, Armisén R, Colombo A, Martínez G, Eguiguren AL, Díaz A, Kiviluoto S, Rodríguez D, Patron M, Rizzuto R, Bultynck G, Concha ML, Sierralta J, Stutzin A, Hetz C. TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis. Cell Death Differ. 2012 Jun; 19(6):1013-26. PMID: 22240901; PMCID: PMC3354055.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  132. Hetz C, Martinon F, Rodriguez D, Glimcher LH. The unfolded protein response: integrating stress signals through the stress sensor IRE1a. Physiol Rev. 2011 Oct; 91(4):1219-43. PMID: 22013210.
    Citations: 165     Fields:    Translation:HumansCells
  133. Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C. BAX inhibitor-1 regulates autophagy by controlling the IRE1a branch of the unfolded protein response. EMBO J. 2011 Sep 16; 30(21):4465-78. PMID: 21926971; PMCID: PMC3230375.
    Citations: 34     Fields:    Translation:AnimalsCells
  134. Torres M, Encina G, Soto C, Hetz C. Abnormal calcium homeostasis and protein folding stress at the ER: A common factor in familial and infectious prion disorders. Commun Integr Biol. 2011 May; 4(3):258-61. PMID: 21980554; PMCID: PMC3187882.
    Citations: 10     
  135. Woehlbier U, Hetz C. Modulating stress responses by the UPRosome: a matter of life and death. Trends Biochem Sci. 2011 Jun; 36(6):329-37. PMID: 21482118.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  136. Hetz C, Glimcher LH. Protein homeostasis networks in physiology and disease. Curr Opin Cell Biol. 2011 Apr; 23(2):123-5. PMID: 21306885; PMCID: PMC3078169.
    Citations: 6     Fields:    Translation:HumansCells
  137. Nassif M, Hetz C. Targeting autophagy in ALS: a complex mission. Autophagy. 2011 Apr; 7(4):450-3. PMID: 21252621.
    Citations: 16     Fields:    Translation:AnimalsCells
  138. Vidal R, Caballero B, Couve A, Hetz C. Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease. Curr Mol Med. 2011 Feb; 11(1):1-12. PMID: 21189122.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  139. Matus S, Glimcher LH, Hetz C. Protein folding stress in neurodegenerative diseases: a glimpse into the ER. Curr Opin Cell Biol. 2011 Apr; 23(2):239-52. PMID: 21288706.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  140. Barrientos SA, Martinez NW, Yoo S, Jara JS, Zamorano S, Hetz C, Twiss JL, Alvarez J, Court FA. Axonal degeneration is mediated by the mitochondrial permeability transition pore. J Neurosci. 2011 Jan 19; 31(3):966-78. PMID: 21248121.
    Citations: 76     Fields:    Translation:AnimalsCells
  141. Paula-Lima AC, Adasme T, SanMartín C, Sebollela A, Hetz C, Carrasco MA, Ferreira ST, Hidalgo C. Amyloid ß-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in hippocampal neurons and prevent RyR-mediated dendritic spine remodeling produced by BDNF. Antioxid Redox Signal. 2011 Apr 01; 14(7):1209-23. PMID: 20712397.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  142. Torres M, Castillo K, Armisén R, Stutzin A, Soto C, Hetz C. Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stress. PLoS One. 2010 Dec 29; 5(12):e15658. PMID: 21209925; PMCID: PMC3012133.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  143. Rodriguez D, Rojas-Rivera D, Hetz C. Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat. Biochim Biophys Acta. 2011 Apr; 1813(4):564-74. PMID: 21122809.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  144. Klein A, Maldonado C, Vargas LM, Gonzalez M, Robledo F, Perez de Arce K, Muñoz FJ, Hetz C, Alvarez AR, Zanlungo S. Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons. Neurobiol Dis. 2011 Jan; 41(1):209-18. PMID: 20883783.
    Citations: 18     Fields:    Translation:AnimalsCells
  145. Nassif M, Matus S, Castillo K, Hetz C. Amyotrophic lateral sclerosis pathogenesis: a journey through the secretory pathway. Antioxid Redox Signal. 2010 Dec 15; 13(12):1955-89. PMID: 20560784.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  146. Klein A, Mosqueira M, Martínez G, Robledo F, González M, Caballero B, Cancino GI, Alvarez AR, Hetz C, Zanlungo S. Lack of activation of the unfolded protein response in mouse and cellular models of Niemann-Pick type C disease. Neurodegener Dis. 2011; 8(3):124-8. PMID: 20714112.
    Citations: 5     Fields:    Translation:AnimalsCells
  147. Gupta S, Deepti A, Deegan S, Lisbona F, Hetz C, Samali A. HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction. PLoS Biol. 2010 Jul 06; 8(7):e1000410. PMID: 20625543; PMCID: PMC2897763.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  148. Rojas-Rivera D, Caballero B, Zamorano S, Lisbona F, Hetz C. Alternative functions of the BCL-2 protein family at the endoplasmic reticulum. Adv Exp Med Biol. 2010; 687:33-47. PMID: 20919636.
    Citations: 4     Fields:    Translation:AnimalsCells
  149. Hetz C. BCL-2 protein family. Essential regulators of cell death. Preface. Adv Exp Med Biol. 2010; 687:vii-viii. PMID: 20919634.
    Citations: 4     Fields:    
  150. Matus S, Nassif M, Glimcher LH, Hetz C. XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy. Autophagy. 2009 Nov; 5(8):1226-8. PMID: 19855189.
    Citations: 16     Fields:    Translation:AnimalsCells
  151. Hetz C, Thielen P, Matus S, Nassif M, Court F, Kiffin R, Martinez G, Cuervo AM, Brown RH, Glimcher LH. XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev. 2009 Oct 01; 23(19):2294-306. PMID: 19762508; PMCID: PMC2758741.
    Citations: 186     Fields:    Translation:HumansAnimalsCells
  152. Hetz C, Glimcher LH. Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome. Mol Cell. 2009 Sep 11; 35(5):551-61. PMID: 19748352; PMCID: PMC3101568.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  153. Lisbona F, Hetz C. Turning off the unfolded protein response: an interplay between the apoptosis machinery and ER stress signaling. Cell Cycle. 2009 Jun 01; 8(11):1643-4. PMID: 19411860.
    Citations: 4     Fields:    Translation:HumansCells
  154. Lisbona F, Rojas-Rivera D, Thielen P, Zamorano S, Todd D, Martinon F, Glavic A, Kress C, Lin JH, Walter P, Reed JC, Glimcher LH, Hetz C. BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell. 2009 Mar 27; 33(6):679-91. PMID: 19328063; PMCID: PMC2818874.
    Citations: 110     Fields:    Translation:HumansAnimalsCells
  155. Hetz C. The UPR as a survival factor of cancer cells: More than folding proteins? Leuk Res. 2009 Jul; 33(7):880-2. PMID: 19285722.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  156. Matus S, Lisbona F, Torres M, León C, Thielen P, Hetz C. The stress rheostat: an interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration. Curr Mol Med. 2008 May; 8(3):157-72. PMID: 18473817.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  157. Hetz C. Apoptosis, necrosis and autophagy: from mechanisms to biomedical applications. Curr Mol Med. 2008 Mar; 8(2):76-7. PMID: 18336288.
    Citations: 1     Fields:    Translation:HumansAnimals
  158. Hetz C, Lee AH, Gonzalez-Romero D, Thielen P, Castilla J, Soto C, Glimcher LH. Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. Proc Natl Acad Sci U S A. 2008 Jan 15; 105(2):757-62. PMID: 18178615; PMCID: PMC2206609.
    Citations: 59     Fields:    Translation:AnimalsCells
  159. Hetz C, Glimcher L. The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology. Trends Cell Biol. 2008 Jan; 18(1):38-44. PMID: 18077169.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  160. Hetz CA. ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damage. Antioxid Redox Signal. 2007 Dec; 9(12):2345-55. PMID: 17854276.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  161. Steele AD, King OD, Jackson WS, Hetz CA, Borkowski AW, Thielen P, Wollmann R, Lindquist S. Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo. J Neurosci. 2007 Nov 21; 27(47):13022-7. PMID: 18032675; PMCID: PMC2588055.
    Citations: 18     Fields:    Translation:AnimalsCells
  162. Steele AD, Hetz C, Yi CH, Jackson WS, Borkowski AW, Yuan J, Wollmann RH, Lindquist S. Prion pathogenesis is independent of caspase-12. Prion. 2007 Oct-Dec; 1(4):243-7. PMID: 19164919; PMCID: PMC2634538.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  163. Hetz C, Thielen P, Fisher J, Pasinelli P, Brown RH, Korsmeyer S, Glimcher L. The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis. Cell Death Differ. 2007 Jul; 14(7):1386-9. PMID: 17510659.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  164. Hetz C, Castilla J, Soto C. Perturbation of endoplasmic reticulum homeostasis facilitates prion replication. J Biol Chem. 2007 Apr 27; 282(17):12725-33. PMID: 17329244; PMCID: PMC2804266.
    Citations: 29     Fields:    Translation:HumansCells
  165. Hetz C, Bernasconi P, Fisher J, Lee AH, Bassik MC, Antonsson B, Brandt GS, Iwakoshi NN, Schinzel A, Glimcher LH, Korsmeyer SJ. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science. 2006 Apr 28; 312(5773):572-6. PMID: 16645094.
    Citations: 203     Fields:    Translation:HumansAnimalsCells
  166. Hetz CA, Soto C. Emerging roles of the unfolded protein response signaling in physiology and disease. Curr Mol Med. 2006 Feb; 6(1):1. PMID: 16472109.
    Citations: 4     Fields:    Translation:HumansCells
  167. Hetz CA, Soto C. Stressing out the ER: a role of the unfolded protein response in prion-related disorders. Curr Mol Med. 2006 Feb; 6(1):37-43. PMID: 16472111; PMCID: PMC2838391.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  168. Hetz C, Vitte PA, Bombrun A, Rostovtseva TK, Montessuit S, Hiver A, Schwarz MK, Church DJ, Korsmeyer SJ, Martinou JC, Antonsson B. Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia. J Biol Chem. 2005 Dec 30; 280(52):42960-70. PMID: 16219766.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  169. Hetz CA, Torres V, Quest AF. Beyond apoptosis: nonapoptotic cell death in physiology and disease. Biochem Cell Biol. 2005 Oct; 83(5):579-88. PMID: 16234846.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  170. Schinzel AC, Takeuchi O, Huang Z, Fisher JK, Zhou Z, Rubens J, Hetz C, Danial NN, Moskowitz MA, Korsmeyer SJ. Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12005-10. PMID: 16103352; PMCID: PMC1189333.
    Citations: 277     Fields:    Translation:AnimalsCells
  171. Castilla J, Saá P, Hetz C, Soto C. In vitro generation of infectious scrapie prions. Cell. 2005 Apr 22; 121(2):195-206. PMID: 15851027.
    Citations: 261     Fields:    Translation:AnimalsCells
  172. Hetz C, Russelakis-Carneiro M, Wälchli S, Carboni S, Vial-Knecht E, Maundrell K, Castilla J, Soto C. The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity. J Neurosci. 2005 Mar 16; 25(11):2793-802. PMID: 15772339.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  173. Russelakis-Carneiro M, Hetz C, Maundrell K, Soto C. Prion replication alters the distribution of synaptophysin and caveolin 1 in neuronal lipid rafts. Am J Pathol. 2004 Nov; 165(5):1839-48. PMID: 15509552; PMCID: PMC1618653.
    Citations: 20     Fields:    Translation:AnimalsCells
  174. Castilla J, Hetz C, Soto C. Molecular mechanisms of neurotoxicity of pathological prion protein. Curr Mol Med. 2004 Jun; 4(4):397-403. PMID: 15354870.
    Citations: 7     Fields:    Translation:Cells
  175. Hetz C, Russelakis-Carneiro M, Maundrell K, Castilla J, Soto C. Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. EMBO J. 2003 Oct 15; 22(20):5435-45. PMID: 14532116; PMCID: PMC213791.
    Citations: 123     Fields:    Translation:HumansAnimalsCells
  176. Hetz C, Maundrell K, Soto C. Is loss of function of the prion protein the cause of prion disorders? Trends Mol Med. 2003 Jun; 9(6):237-43. PMID: 12829011.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  177. Hetz C, Soto C. Protein misfolding and disease: the case of prion disorders. Cell Mol Life Sci. 2003 Jan; 60(1):133-43. PMID: 12613663.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  178. Hetz CA, Hunn M, Rojas P, Torres V, Leyton L, Quest AF. Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase. J Cell Sci. 2002 Dec 01; 115(Pt 23):4671-83. PMID: 12415011.
    Citations: 27     Fields:    Translation:HumansCells
  179. Hetz C, Bono MR, Barros LF, Lagos R. Microcin E492, a channel-forming bacteriocin from Klebsiella pneumoniae, induces apoptosis in some human cell lines. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2696-701. PMID: 11880624; PMCID: PMC122410.
    Citations: 23     Fields:    Translation:HumansCells
  180. Lagos R, Baeza M, Corsini G, Hetz C, Strahsburger E, Castillo JA, Vergara C, Monasterio O. Structure, organization and characterization of the gene cluster involved in the production of microcin E492, a channel-forming bacteriocin. Mol Microbiol. 2001 Oct; 42(1):229-43. PMID: 11679081.
    Citations: 25     Fields:    Translation:Cells
  181. Leyton L, Schneider P, Labra CV, Rüegg C, Hetz CA, Quest AF, Bron C. Thy-1 binds to integrin beta(3) on astrocytes and triggers formation of focal contact sites. Curr Biol. 2001 Jul 10; 11(13):1028-38. PMID: 11470407.
    Citations: 33     Fields:    Translation:AnimalsCells
  182. Barros LF, Stutzin A, Calixto A, Catalán M, Castro J, Hetz C, Hermosilla T. Nonselective cation channels as effectors of free radical-induced rat liver cell necrosis. Hepatology. 2001 Jan; 33(1):114-22. PMID: 11124827.
    Citations: 18     Fields:    Translation:AnimalsCells
  183. Kleeberg I, Hetz C, Kroppenstedt RM, Müller RJ, Deckwer WD. Biodegradation of aliphatic-aromatic copolyesters by Thermomonospora fusca and other thermophilic compost isolates. Appl Environ Microbiol. 1998 May; 64(5):1731-5. PMID: 9572944; PMCID: PMC106223.
    Citations: 9     Fields:    Translation:CellsPHPublic Health
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.