Qiufu Ma, Ph.D.
|Title||Professor of Neurobiology|
|Institution||Dana-Farber Cancer Institute|
|Address||Dana Farber Cancer Institute|
Cancer Biology/MA, Smith 1022
44 Binney St
Boston MA 02115
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Available: 06/01/12, Expires: 06/02/15
Itch can be suppressed by painful stimuli. That is why we scratch at an itch. In human patients suffering chronic itch, pain-induced itch inhibition was abolished. It is also well known by clinicians that pain relief by opioids can sometimes induce itch side effects. The goal of this project is to dissect the neural circuits that mediate itch inhibition by pain. To do this, the students will be part of a team to use mouse genetic manipulations to ablate or silence specific populations of excitatory or inhibitory neurons in the dorsal spinal cord, followed by determining whether or not pain-induced itch inhibition is affected.
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