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Michael Springer, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM120122 (SPRINGER, MICHAEL) Sep 1, 2016 - Jul 31, 2021
    Determining the source of missing heritability
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Welch NL, Zhu M, Hua C, Weller J, Mirhashemi ME, Nguyen TG, Mantena S, Bauer MR, Shaw BM, Ackerman CM, Thakku SG, Tse MW, Kehe J, Uwera MM, Eversley JS, Bielwaski DA, McGrath G, Braidt J, Johnson J, Cerrato F, Moreno GK, Krasilnikova LA, Petros BA, Gionet GL, King E, Huard RC, Jalbert SK, Cleary ML, Fitzgerald NA, Gabriel SB, Gallagher GR, Smole SC, Madoff LC, Brown CM, Keller MW, Wilson MM, Kirby MK, Barnes JR, Park DJ, Siddle KJ, Happi CT, Hung DT, Springer M, MacInnis BL, Lemieux JE, Rosenberg E, Branda JA, Blainey PC, Sabeti PC, Myhrvold C. Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants. Nat Med. 2022 Feb 07. PMID: 35130561.
    Citations:    Fields:    
  2. Liu AB, Davidi D, Landsberg HE, Francesconi M, Platt JT, Nguyen GT, Yune S, Deckard A, Puglin J, Haase SB, Hamer DH, Springer M. Association of COVID-19 Quarantine Duration and Postquarantine Transmission Risk in 4 University Cohorts. JAMA Netw Open. 2022 02 01; 5(2):e220088. PMID: 35212750.
    Citations:    Fields:    Translation:HumansPHPublic Health
  3. Hong J, Palme J, Hua B, Springer M. Computational analysis of GAL pathway pinpoints mechanisms underlying natural variation. PLoS Comput Biol. 2021 09; 17(9):e1008691. PMID: 34570755.
    Citations:    Fields:    Translation:Animals
  4. Palme J, Wang J, Springer M. Variation in the modality of a yeast signaling pathway is mediated by a single regulator. Elife. 2021 08 09; 10. PMID: 34369878.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. Mancuso CP, Lu ZX, Qian J, Boswell SA, Springer M. A Semi-Quantitative Isothermal Diagnostic Assay Utilizing Competitive Amplification. Anal Chem. 2021 07 13; 93(27):9541-9548. PMID: 34180655.
    Citations: 1     Fields:    Translation:HumansCells
  6. Pettit ME, Boswell SA, Qian J, Novak R, Springer M. Accessioning and automation compatible anterior nares swab design. J Virol Methods. 2021 08; 294:114153. PMID: 33984398.
    Citations: 2     Fields:    Translation:HumansCells
  7. Davidi D, Fitzgerald S, Glaspell HL, Jalbert S, Klapperich CM, Landaverde L, Maheras S, Mattoon SE, Britto VM, Nguyen GT, Platt JT, Kuhfeldt K, Landsberg H, Stuopis CW, Turse JE, Hamer DH, Springer M. Amplicon residues in research laboratories masquerade as COVID-19 in surveillance tests. Cell Rep Methods. 2021 May 24; 1(1):100005. PMID: 34235497.
    Citations: 3     
  8. Hong J, Hua B, Springer M, Tang C. Computational study on ratio-sensing in yeast galactose utilization pathway. PLoS Comput Biol. 2020 12; 16(12):e1007960. PMID: 33275601.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Qian J, Boswell SA, Chidley C, Lu ZX, Pettit ME, Gaudio BL, Fajnzylber JM, Ingram RT, Ward RH, Li JZ, Springer M. An enhanced isothermal amplification assay for viral detection. Nat Commun. 2020 11 20; 11(1):5920. PMID: 33219228.
    Citations: 18     Fields:    Translation:HumansCells
  10. Qian J, Lu ZX, Mancuso CP, Jhuang HY, Del Carmen Barajas-Ornelas R, Boswell SA, Ramírez-Guadiana FH, Jones V, Sonti A, Sedlack K, Artzi L, Jung G, Arammash M, Pettit ME, Melfi M, Lyon L, Owen SV, Baym M, Khalil AS, Silver PA, Rudner DZ, Springer M. Barcoded microbial system for high-resolution object provenance. Science. 2020 06 05; 368(6495):1135-1140. PMID: 32499444.
    Citations: 4     Fields:    Translation:CellsPHPublic Health
  11. Qian J, Boswell SA, Chidley C, Lu ZX, Pettit ME, Gaudio BL, Fajnzylber JM, Ingram RT, Ward RH, Li JZ, Springer M. An enhanced isothermal amplification assay for viral detection. bioRxiv. 2020 May 29. PMID: 32577657.
  12. Tye BW, Commins N, Ryazanova LV, Wühr M, Springer M, Pincus D, Churchman LS. Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness. Elife. 2019 03 07; 8. PMID: 30843788.
    Citations: 31     Fields:    Translation:AnimalsCells
  13. Springer M. Evaluation of Dunphy et al.: Suggestions to Solidify, Clarify, and Focus without Substantial New Work. Cell Syst. 2019 01 23; 8(1):1-2. PMID: 30677398.
    Citations:    Fields:    Translation:Cells
  14. Hua B, Springer M. Widespread Cumulative Influence of Small Effect Size Mutations on Yeast Quantitative Traits. Cell Syst. 2018 12 26; 7(6):590-600.e6. PMID: 30579728.
    Citations: 1     Fields:    Translation:Animals
  15. Richard M, Chuffart F, Duplus-Bottin H, Pouyet F, Spichty M, Fulcrand E, Entrevan M, Barthelaix A, Springer M, Jost D, Yvert G. Assigning function to natural allelic variation via dynamic modeling of gene network induction. Mol Syst Biol. 2018 01 15; 14(1):e7803. PMID: 29335276.
    Citations: 1     Fields:    Translation:AnimalsCells
  16. Lee KB, Wang J, Palme J, Escalante-Chong R, Hua B, Springer M. Polymorphisms in the yeast galactose sensor underlie a natural continuum of nutrient-decision phenotypes. PLoS Genet. 2017 May; 13(5):e1006766. PMID: 28542190.
    Citations: 6     Fields:    Translation:Animals
  17. Savir Y, Martynov A, Springer M. Achieving global perfect homeostasis through transporter regulation. PLoS Comput Biol. 2017 04; 13(4):e1005458. PMID: 28414718.
    Citations: 5     Fields:    Translation:Animals
  18. Beach RR, Ricci-Tam C, Brennan CM, Moomau CA, Hsu PH, Hua B, Silberman RE, Springer M, Amon A. Aneuploidy Causes Non-genetic Individuality. Cell. 2017 04 06; 169(2):229-242.e21. PMID: 28388408.
    Citations: 38     Fields:    Translation:Animals
  19. Boswell SA, Snavely A, Landry HM, Churchman LS, Gray JM, Springer M. Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis. Nat Chem Biol. 2017 05; 13(5):501-507. PMID: 28263964.
    Citations: 12     Fields:    Translation:HumansCells
  20. Hopf TA, Ingraham JB, Poelwijk FJ, Schärfe CP, Springer M, Sander C, Marks DS. Mutation effects predicted from sequence co-variation. Nat Biotechnol. 2017 02; 35(2):128-135. PMID: 28092658.
    Citations: 147     Fields:    Translation:HumansCells
  21. Katz Y, Springer M. Probabilistic adaptation in changing microbial environments. PeerJ. 2016; 4:e2716. PMID: 27994963.
    Citations: 5     
  22. Gerardin Y, Springer M, Kishony R. A competitive trade-off limits the selective advantage of increased antibiotic production. Nat Microbiol. 2016 Sep 26; 1:16175. PMID: 27668360.
    Citations: 11     Fields:    
  23. DeGennaro CM, Savir Y, Springer M. Identifying Metabolic Subpopulations from Population Level Mass Spectrometry. PLoS One. 2016; 11(3):e0151659. PMID: 26986964.
    Citations: 1     Fields:    Translation:AnimalsCells
  24. Torres EM, Springer M, Amon A. No current evidence for widespread dosage compensation in S. cerevisiae. Elife. 2016 Mar 07; 5:e10996. PMID: 26949255.
    Citations: 19     Fields:    Translation:Animals
  25. Jajoo R, Jung Y, Huh D, Viana MP, Rafelski SM, Springer M, Paulsson J. Accurate concentration control of mitochondria and nucleoids. Science. 2016 Jan 08; 351(6269):169-72. PMID: 26744405.
    Citations: 33     Fields:    Translation:AnimalsCells
  26. Savir Y, Tu BP, Springer M. Competitive inhibition can linearize dose-response and generate a linear rectifier. Cell Syst. 2015 Sep 23; 1(3):238-245. PMID: 26495436.
    Citations: 3     Fields:    
  27. Stefan MI, Gutlerner JL, Born RT, Springer M. The quantitative methods boot camp: teaching quantitative thinking and computing skills to graduate students in the life sciences. PLoS Comput Biol. 2015 Apr; 11(4):e1004208. PMID: 25880064.
    Citations: 12     Fields:    Translation:Humans
  28. Wang J, Atolia E, Hua B, Savir Y, Escalante-Chong R, Springer M. Natural variation in preparation for nutrient depletion reveals a cost-benefit tradeoff. PLoS Biol. 2015 Jan; 13(1):e1002041. PMID: 25626068.
    Citations: 50     Fields:    Translation:AnimalsCells
  29. Escalante-Chong R, Savir Y, Carroll SM, Ingraham JB, Wang J, Marx CJ, Springer M. Galactose metabolic genes in yeast respond to a ratio of galactose and glucose. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1636-41. PMID: 25605920.
    Citations: 43     Fields:    Translation:AnimalsCells
  30. Muntel J, Boswell SA, Tang S, Ahmed S, Wapinski I, Foley G, Steen H, Springer M. Abundance-based classifier for the prediction of mass spectrometric peptide detectability upon enrichment (PPA). Mol Cell Proteomics. 2015 Feb; 14(2):430-40. PMID: 25473088.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  31. Marquardt S, Escalante-Chong R, Pho N, Wang J, Churchman LS, Springer M, Buratowski S. A Chromatin-Based Mechanism for Limiting Divergent Noncoding Transcription. Cell. 2014 Jul 17; 158(2):462. PMID: 28915368.
    Citations: 4     Fields:    
  32. Marquardt S, Escalante-Chong R, Pho N, Wang J, Churchman LS, Springer M, Buratowski S. A chromatin-based mechanism for limiting divergent noncoding transcription. Cell. 2014 Jun 19; 157(7):1712-23. PMID: 24949978.
    Citations: 61     Fields:    Translation:AnimalsCells
  33. Gray JM, Harmin DA, Boswell SA, Cloonan N, Mullen TE, Ling JJ, Miller N, Kuersten S, Ma YC, McCarroll SA, Grimmond SM, Springer M. SnapShot-Seq: a method for extracting genome-wide, in vivo mRNA dynamics from a single total RNA sample. PLoS One. 2014; 9(2):e89673. PMID: 24586954.
    Citations: 24     Fields:    Translation:HumansCells
  34. Lim SC, Friemel M, Marum JE, Tucker EJ, Bruno DL, Riley LG, Christodoulou J, Kirk EP, Boneh A, DeGennaro CM, Springer M, Mootha VK, Rouault TA, Leimkühler S, Thorburn DR, Compton AG. Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes. Hum Mol Genet. 2013 Nov 15; 22(22):4460-73. PMID: 23814038.
    Citations: 48     Fields:    Translation:HumansCells
  35. Merbl Y, Refour P, Patel H, Springer M, Kirschner MW. Profiling of ubiquitin-like modifications reveals features of mitotic control. Cell. 2013 Feb 28; 152(5):1160-72. PMID: 23452859.
    Citations: 43     Fields:    Translation:HumansCells
  36. Busby MA, Gray JM, Costa AM, Stewart C, Stromberg MP, Barnett D, Chuang JH, Springer M, Marth GT. Expression divergence measured by transcriptome sequencing of four yeast species. BMC Genomics. 2011 Dec 29; 12:635. PMID: 22206443.
    Citations: 18     Fields:    Translation:AnimalsCells
  37. Springer M, Weissman JS, Kirschner MW. A general lack of compensation for gene dosage in yeast. Mol Syst Biol. 2010 May 11; 6:368. PMID: 20461075.
    Citations: 73     Fields:    Translation:Animals
  38. DeLuna A, Springer M, Kirschner MW, Kishony R. Need-based up-regulation of protein levels in response to deletion of their duplicate genes. PLoS Biol. 2010 Mar 30; 8(3):e1000347. PMID: 20361019.
    Citations: 42     Fields:    Translation:AnimalsCells
  39. Milo R, Jorgensen P, Moran U, Weber G, Springer M. BioNumbers--the database of key numbers in molecular and cell biology. Nucleic Acids Res. 2010 Jan; 38(Database issue):D750-3. PMID: 19854939.
    Citations: 329     Fields:    Translation:HumansAnimals
  40. Singh S, Springer M, Steen J, Kirschner MW, Steen H. FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides. J Proteome Res. 2009 May; 8(5):2201-10. PMID: 19344176.
    Citations: 37     Fields:    Translation:HumansCells
  41. Kafri R, Springer M, Pilpel Y. Genetic redundancy: new tricks for old genes. Cell. 2009 Feb 06; 136(3):389-92. PMID: 19203571.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  42. Steen JA, Steen H, Georgi A, Parker K, Springer M, Kirchner M, Hamprecht F, Kirschner MW. Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: a quantitative proteomic analysis. Proc Natl Acad Sci U S A. 2008 Apr 22; 105(16):6069-74. PMID: 18420821.
    Citations: 45     Fields:    Translation:HumansCells
  43. Palazzo AF, Springer M, Shibata Y, Lee CS, Dias AP, Rapoport TA. The signal sequence coding region promotes nuclear export of mRNA. PLoS Biol. 2007 Dec; 5(12):e322. PMID: 18052610.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  44. Milo R, Hou JH, Springer M, Brenner MP, Kirschner MW. The relationship between evolutionary and physiological variation in hemoglobin. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):16998-7003. PMID: 17942680.
    Citations: 18     Fields:    Translation:HumansAnimals
  45. Springer M, Paulsson J. Biological physics: harmonies from noise. Nature. 2006 Jan 05; 439(7072):27-8. PMID: 16397487.
    Citations: 13     Fields:    Translation:Cells
  46. Steen H, Jebanathirajah JA, Springer M, Kirschner MW. Stable isotope-free relative and absolute quantitation of protein phosphorylation stoichiometry by MS. Proc Natl Acad Sci U S A. 2005 Mar 15; 102(11):3948-53. PMID: 15741271.
    Citations: 62     Fields:    Translation:AnimalsCells
  47. Byrne M, Miller N, Springer M, O'Shea EK. A distal, high-affinity binding site on the cyclin-CDK substrate Pho4 is important for its phosphorylation and regulation. J Mol Biol. 2004 Jan 02; 335(1):57-70. PMID: 14659740.
    Citations: 8     Fields:    Translation:Cells
  48. Wang D, Urisman A, Liu YT, Springer M, Ksiazek TG, Erdman DD, Mardis ER, Hickenbotham M, Magrini V, Eldred J, Latreille JP, Wilson RK, Ganem D, DeRisi JL. Viral discovery and sequence recovery using DNA microarrays. PLoS Biol. 2003 Nov; 1(2):E2. PMID: 14624234.
    Citations: 205     Fields:    Translation:HumansCells
  49. Springer M, Wykoff DD, Miller N, O'Shea EK. Partially phosphorylated Pho4 activates transcription of a subset of phosphate-responsive genes. PLoS Biol. 2003 Nov; 1(2):E28. PMID: 14624238.
    Citations: 51     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.