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Vassiliki A. Boussiotis, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA238263 (BOUSSIOTIS, VASSILIKI A) Feb 10, 2020 - Jan 31, 2025
    The effects of PD-1 on tumor-mediated ?emergency? myelopoiesis and fate commitment of myeloid cells: Implications for anti-tumor immunity
    Role: Principal Investigator
  2. R01CA229784 (CHAREST, ALAIN) Jul 1, 2018 - Jun 30, 2023
    Advancing treatment outcomes in malignant glioma by integrating immunotherapy and standard of care using genetically engineered mice that recapitulate molecular feature of human glioma
    Role: Co-Principal Investigator
  3. R01CA212605 (BOUSSIOTIS, VASSILIKI A) Jun 14, 2017 - May 31, 2022
    Improving anti-tumor T cell immunity by targeting LDH-A functions beyond the Warburg effect
    Role: Principal Investigator
  4. R56AI098129 (BOUSSIOTIS, VASSILIKI A) Aug 15, 2013 - Jul 31, 2015
    The role of RIAM in T cell immunity and tolerance
    Role: Principal Investigator
  5. R01CA183605 (BOUSSIOTIS, VASSILIKI A) Jul 17, 2013 - Apr 30, 2018
    Effects of PGE2 on reconstitution of hematopoiesis and immunity after UCBT
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Daneshmandi S, Cassel T, Lin P, Higashi RM, Wulf GM, Boussiotis VA, Fan TW, Seth P. Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function. Cell Rep. 2021 Mar 09; 34(10):108831. PMID: 33691103.
    Citations:    Fields:    
  2. Christofides A, Tijaro-Ovalle NM, Boussiotis VA. Commentary on: Combination of Metabolic Intervention and T Cell Therapy Enhances Solid Tumor Immunotherapy. Immunometabolism. 2021; 3(2). PMID: 33927895.
  3. Aksoylar HI, Boussiotis VA. PD-1+ Treg cells: a foe in cancer immunotherapy? Nat Immunol. 2020 11; 21(11):1311-1312. PMID: 32973361.
    Citations: 2     Fields:    Translation:HumansCells
  4. Bardhan K, Aksoylar HI, Le Bourgeois T, Strauss L, Weaver JD, Delcuze B, Charest A, Patsoukis N, Boussiotis VA. Publisher Correction: Phosphorylation of PD-1-Y248 is a marker of PD-1-mediated inhibitory function in human T cells. Sci Rep. 2020 Sep 23; 10(1):15905. PMID: 32963251.
    Citations:    Fields:    
  5. Patsoukis N, Wang Q, Strauss L, Boussiotis VA. Revisiting the PD-1 pathway. Sci Adv. 2020 Sep; 6(38). PMID: 32948597.
    Citations: 13     Fields:    
  6. Christofides A, Konstantinidou E, Jani C, Boussiotis VA. The role of peroxisome proliferator-activated receptors (PPAR) in immune responses. Metabolism. 2021 01; 114:154338. PMID: 32791172.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  7. Aksoylar HI, Tijaro-Ovalle NM, Boussiotis VA, Patsoukis N. T Cell Metabolism in Cancer Immunotherapy. Immunometabolism. 2020; 2(3). PMID: 32642279.
    Citations: 4     
  8. Patsoukis N, Duke-Cohan JS, Chaudhri A, Aksoylar HI, Wang Q, Council A, Berg A, Freeman GJ, Boussiotis VA. Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation. Commun Biol. 2020 03 17; 3(1):128. PMID: 32184441.
    Citations: 8     
  9. Strauss L, Mahmoud MAA, Weaver JD, Tijaro-Ovalle NM, Christofides A, Wang Q, Pal R, Yuan M, Asara J, Patsoukis N, Boussiotis VA. Targeted deletion of PD-1 in myeloid cells induces antitumor immunity. Sci Immunol. 2020 01 03; 5(43). PMID: 31901074.
    Citations: 54     Fields:    Translation:AnimalsCells
  10. Bardhan K, Aksoylar HI, Le Bourgeois T, Strauss L, Weaver JD, Delcuze B, Charest A, Patsoukis N, Boussiotis VA. Phosphorylation of PD-1-Y248 is a marker of PD-1-mediated inhibitory function in human T cells. Sci Rep. 2019 11 21; 9(1):17252. PMID: 31754127.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  11. DeFilipp Z, Li S, Avigan D, Armand P, Ho VT, Koreth J, Nikiforow S, Alyea EP, Ritz J, Boussiotis V, Rosenblatt J, Brown J, McAfee S, Dey BR, El-Jawahri A, Spitzer TR, Chen YB, Soiffer RJ, Antin JH, Ballen KK, Cutler CS. A phase II study of reduced intensity double umbilical cord blood transplantation using fludarabine, melphalan, and low dose total body irradiation. Bone Marrow Transplant. 2020 04; 55(4):804-810. PMID: 31616065.
    Citations:    Fields:    
  12. Karantanos T, Kim HT, Tijaro-Ovalle NM, Li L, Cutler C, Antin JH, Ballen KK, Ritz J, Politikos I, Boussiotis VA. Assessment of a multi-cytokine profile by a novel biochip-based assay allows correlation of cytokine profiles with clinical outcomes in adult recipients of umbilical cord blood transplantation. Bone Marrow Transplant. 2020 09; 55(9):1821-1823. PMID: 31578466.
    Citations:    Fields:    
  13. Karantanos T, Kim HT, Tijaro-Ovalle NM, Li L, Cutler C, Antin JH, Ballen K, Marty FM, Tan CS, Ritz J, Politikos I, Boussiotis V. Reactivation of BK virus after double umbilical cord blood transplantation in adults correlates with impaired reconstitution of CD4+ and CD8+ T effector memory cells and increase of T regulatory cells. Clin Immunol. 2019 10; 207:18-23. PMID: 31255803.
    Citations: 1     Fields:    Translation:HumansCells
  14. Tijaro-Ovalle NM, Karantanos T, Wang HT, Boussiotis VA. Metabolic Targets for Improvement of Allogeneic Hematopoietic Stem Cell Transplantation and Graft-vs.-Host Disease. Front Immunol. 2019; 10:295. PMID: 30891031.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  15. Mahoney KM, Shukla SA, Patsoukis N, Chaudhri A, Browne EP, Arazi A, Eisenhaure TM, Pendergraft WF, Hua P, Pham HC, Bu X, Zhu B, Hacohen N, Fritsch EF, Boussiotis VA, Wu CJ, Freeman GJ. A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression. Cancer Immunol Immunother. 2019 Mar; 68(3):421-432. PMID: 30564891.
    Citations: 22     Fields:    Translation:HumansCells
  16. Yazicioglu YF, Aksoylar HI, Pal R, Patsoukis N, Boussiotis VA. Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches. J Vis Exp. 2018 11 21; (141). PMID: 30531720.
    Citations:    Fields:    Translation:AnimalsCells
  17. Strauss L, Patsoukis N, Boussiotis VA. Publisher Correction: Feeling stressed? It might be your T cells. Nat Immunol. 2018 Sep; 19(9):1037. PMID: 29955108.
    Citations:    Fields:    
  18. Le Bourgeois T, Strauss L, Aksoylar HI, Daneshmandi S, Seth P, Patsoukis N, Boussiotis VA. Targeting T Cell Metabolism for Improvement of Cancer Immunotherapy. Front Oncol. 2018; 8:237. PMID: 30123774.
    Citations: 38     
  19. Politikos I, McMasters M, Bryke C, Avigan D, Boussiotis VA. Possible reactivation of chromosomally integrated human herpesvirus 6 after treatment with histone deacetylase inhibitor. Blood Adv. 2018 06 26; 2(12):1367-1370. PMID: 29898877.
    Citations: 6     Fields:    Translation:HumansCells
  20. Boussiotis VA, Charest A. Immunotherapies for malignant glioma. Oncogene. 2018 03; 37(9):1121-1141. PMID: 29242608.
    Citations: 31     Fields:    Translation:HumansAnimals
  21. Strauss L, Patsoukis N, Boussiotis VA. Feeling stressed? It might be your T cells. Nat Immunol. 2017 11 16; 18(12):1281-1283. PMID: 29144505.
    Citations:    Fields:    Translation:AnimalsCells
  22. Patsoukis N, Bardhan K, Weaver JD, Sari D, Torres-Gomez A, Li L, Strauss L, Lafuente EM, Boussiotis VA. The adaptor molecule RIAM integrates signaling events critical for integrin-mediated control of immune function and cancer progression. Sci Signal. 2017 Aug 22; 10(493). PMID: 28831022.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  23. Karantanos T, Politikos I, Boussiotis VA. Advances in the pathophysiology and treatment of relapsed/refractory Hodgkin's lymphoma with an emphasis on targeted therapies and transplantation strategies. Blood Lymphat Cancer. 2017; 7:37-52. PMID: 28701859.
    Citations: 2     
  24. Patsoukis N, Weaver JD, Strauss L, Herbel C, Seth P, Boussiotis VA. Immunometabolic Regulations Mediated by Coinhibitory Receptors and Their Impact on T Cell Immune Responses. Front Immunol. 2017; 8:330. PMID: 28443090.
    Citations: 18     Fields:    
  25. Christofides A, Karantanos T, Bardhan K, Boussiotis VA. Epigenetic regulation of cancer biology and anti-tumor immunity by EZH2. Oncotarget. 2016 Dec 20; 7(51):85624-85640. PMID: 27793053.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  26. Bardhan K, Anagnostou T, Boussiotis VA. The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation. Front Immunol. 2016; 7:550. PMID: 28018338.
    Citations: 122     Fields:    
  27. Rosenblatt J, Stone RM, Uhl L, Neuberg D, Joyce R, Levine JD, Arnason J, McMasters M, Luptakova K, Jain S, Zwicker JI, Hamdan A, Boussiotis V, Steensma DP, DeAngelo DJ, Galinsky I, Dutt PS, Logan E, Bryant MP, Stroopinsky D, Werner L, Palmer K, Coll M, Washington A, Cole L, Kufe D, Avigan D. Individualized vaccination of AML patients in remission is associated with induction of antileukemia immunity and prolonged remissions. Sci Transl Med. 2016 12 07; 8(368):368ra171. PMID: 27928025.
    Citations: 55     Fields:    Translation:HumansCellsPHPublic Health
  28. Boussiotis VA. Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway. N Engl J Med. 2016 Nov 03; 375(18):1767-1778. PMID: 27806234.
    Citations: 261     Fields:    Translation:HumansCells
  29. Karantanos T, Boussiotis VA. JAK3-mediated phosphorylation of EZH2: a novel mechanism of non-canonical EZH2 activation and oncogenic function. Transl Cancer Res. 2016 Nov; 5(Suppl 6):S1208-S1211. PMID: 28868240.
    Citations: 2     
  30. Politikos I, T Kim H, Karantanos T, Brown J, McDonough S, Li L, Cutler C, Antin JH, Ballen KK, Ritz J, Boussiotis VA. Angiogenic Factors Correlate with T Cell Immune Reconstitution and Clinical Outcomes after Double-Unit Umbilical Cord Blood Transplantation in Adults. Biol Blood Marrow Transplant. 2017 01; 23(1):103-112. PMID: 27777141.
    Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
  31. Karantanos T, Christofides A, Bardhan K, Li L, Boussiotis VA. Corrigendum: Regulation of T Cell Differentiation and Function by EZH2. Front Immunol. 2016; 7:346. PMID: 27648006.
    Citations:    Fields:    
  32. Herbel C, Patsoukis N, Bardhan K, Seth P, Weaver JD, Boussiotis VA. Clinical significance of T cell metabolic reprogramming in cancer. Clin Transl Med. 2016 Dec; 5(1):29. PMID: 27510264.
    Citations: 26     
  33. Karantanos T, Chistofides A, Barhdan K, Li L, Boussiotis VA. Regulation of T Cell Differentiation and Function by EZH2. Front Immunol. 2016; 7:172. PMID: 27199994.
    Citations: 27     Fields:    
  34. Patsoukis N, Bardhan K, Weaver J, Herbel C, Seth P, Li L, Boussiotis VA. The role of metabolic reprogramming in T cell fate and function. Curr Trends Immunol. 2016; 17:1-12. PMID: 28356677.
    Citations: 16     
  35. Boussiotis VA. Cell-specific PD-L1 expression in DLBCL. Blood. 2015 Nov 05; 126(19):2171-2. PMID: 26542250.
    Citations: 5     Fields:    Translation:Humans
  36. Politikos I, Kim HT, Nikiforow S, Li L, Brown J, Antin JH, Cutler C, Ballen K, Ritz J, Boussiotis VA. IL-7 and SCF Levels Inversely Correlate with T Cell Reconstitution and Clinical Outcomes after Cord Blood Transplantation in Adults. PLoS One. 2015; 10(7):e0132564. PMID: 26177551.
    Citations: 4     Fields:    Translation:HumansCells
  37. Patsoukis N, Bardhan K, Chatterjee P, Sari D, Liu B, Bell LN, Karoly ED, Freeman GJ, Petkova V, Seth P, Li L, Boussiotis VA. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat Commun. 2015 Mar 26; 6:6692. PMID: 25809635.
    Citations: 265     Fields:    Translation:HumansCells
  38. Satyanarayana G, Hammond SP, Broge TA, Mackenzie MR, Viscidi R, Politikos I, Koralnik IJ, Cutler CS, Ballen K, Boussiotis V, Marty FM, Tan CS. BK polyomavirus reactivation after reduced-intensity double umbilical cord blood cell transplantation. Transpl Immunol. 2015 Mar; 32(2):116-20. PMID: 25536223.
    Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
  39. Boussiotis VA. Somatic mutations and immunotherapy outcome with CTLA-4 blockade in melanoma. N Engl J Med. 2014 Dec 04; 371(23):2230-2. PMID: 25409261.
    Citations: 12     Fields:    Translation:Humans
  40. Politikos I, Boussiotis VA. The role of the thymus in T-cell immune reconstitution after umbilical cord blood transplantation. Blood. 2014 Nov 20; 124(22):3201-11. PMID: 25287708.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  41. Boussiotis VA, Chatterjee P, Li L. Biochemical signaling of PD-1 on T cells and its functional implications. Cancer J. 2014 Jul-Aug; 20(4):265-71. PMID: 25098287.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  42. Nellore A, Liu B, Patsoukis N, Boussiotis VA, Li L. The cyclin dependent kinase inhibitor (R)-roscovitine mediates selective suppression of alloreactive human T cells but preserves pathogen-specific and leukemia-specific effectors. Clin Immunol. 2014 May-Jun; 152(1-2):48-57. PMID: 24631965.
    Citations: 5     Fields:    Translation:HumansCells
  43. Li L, Kim HT, Nellore A, Patsoukis N, Petkova V, McDonough S, Politikos I, Nikiforow S, Soiffer R, Antin JH, Ballen K, Cutler C, Ritz J, Boussiotis VA. Prostaglandin E2 promotes survival of naive UCB T cells via the Wnt/ß-catenin pathway and alters immune reconstitution after UCBT. Blood Cancer J. 2014 Jan 17; 4:e178. PMID: 24442207.
    Citations: 16     Fields:    
  44. Patsoukis N, Li L, Sari D, Petkova V, Boussiotis VA. PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2. Mol Cell Biol. 2013 Aug; 33(16):3091-8. PMID: 23732914.
    Citations: 61     Fields:    Translation:HumansCells
  45. Rosenblatt J, Avivi I, Vasir B, Uhl L, Munshi NC, Katz T, Dey BR, Somaiya P, Mills H, Campigotto F, Weller E, Joyce R, Levine JD, Tzachanis D, Richardson P, Laubach J, Raje N, Boussiotis V, Yuan YE, Bisharat L, Held V, Rowe J, Anderson K, Kufe D, Avigan D. Vaccination with dendritic cell/tumor fusions following autologous stem cell transplant induces immunologic and clinical responses in multiple myeloma patients. Clin Cancer Res. 2013 Jul 01; 19(13):3640-8. PMID: 23685836.
    Citations: 72     Fields:    Translation:HumansCellsPHPublic Health
  46. Li L, Boussiotis VA. The role of IL-17-producing Foxp3+ CD4+ T cells in inflammatory bowel disease and colon cancer. Clin Immunol. 2013 Aug; 148(2):246-53. PMID: 23773923.
    Citations: 29     Fields:    Translation:HumansCells
  47. Medraño-Fernandez I, Reyes R, Olazabal I, Rodriguez E, Sanchez-Madrid F, Boussiotis VA, Reche PA, Cabañas C, Lafuente EM. RIAM (Rap1-interacting adaptor molecule) regulates complement-dependent phagocytosis. Cell Mol Life Sci. 2013 Jul; 70(13):2395-410. PMID: 23420480.
    Citations: 11     Fields:    Translation:HumansCells
  48. Wynne JP, Wu J, Su W, Mor A, Patsoukis N, Boussiotis VA, Hubbard SR, Philips MR. Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector. J Cell Biol. 2012 Oct 15; 199(2):317-30. PMID: 23045549.
    Citations: 27     Fields:    Translation:HumansCells
  49. Patsoukis N, Sari D, Boussiotis VA. PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A. . 2012 Dec 01; 11(23):4305-9. PMID: 23032366.
    Citations: 47     Translation:HumansCells
  50. Li L, Patsoukis N, Petkova V, Boussiotis VA. Runx1 and Runx3 are involved in the generation and function of highly suppressive IL-17-producing T regulatory cells. PLoS One. 2012; 7(9):e45115. PMID: 22984619.
    Citations: 15     Fields:    Translation:AnimalsCells
  51. Patsoukis N, Brown J, Petkova V, Liu F, Li L, Boussiotis VA. Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation. Sci Signal. 2012 Jun 26; 5(230):ra46. PMID: 22740686.
    Citations: 163     Fields:    Translation:HumansCells
  52. Li L, Boussiotis VA. Molecular and functional heterogeneity of T regulatory cells. Clin Immunol. 2011 Dec; 141(3):244-52. PMID: 21945485.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  53. Hernández-Varas P, Coló GP, Bartolomé RA, Paterson A, Medraño-Fernández I, Arellano-Sánchez N, Cabañas C, Sánchez-Mateos P, Lafuente EM, Boussiotis VA, Strömblad S, Teixidó J. Rap1-GTP-interacting adaptor molecule (RIAM) protein controls invasion and growth of melanoma cells. J Biol Chem. 2011 May 27; 286(21):18492-504. PMID: 21454517.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  54. Li L, Kim Js, Boussiotis VA. Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms. Cell Immunol. 2010; 266(1):7-13. PMID: 20864093.
    Citations: 9     Fields:    Translation:AnimalsCells
  55. Li L, Kim J, Boussiotis VA. IL-1ß-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells. J Immunol. 2010 Oct 01; 185(7):4148-53. PMID: 20817874.
    Citations: 47     Fields:    Translation:AnimalsCells
  56. Cutler C, Stevenson K, Kim HT, Brown J, McDonough S, Herrera M, Reynolds C, Liney D, Kao G, Ho V, Armand P, Koreth J, Alyea E, Dey BR, Attar E, Spitzer T, Boussiotis VA, Ritz J, Soiffer R, Antin JH, Ballen K. Double umbilical cord blood transplantation with reduced intensity conditioning and sirolimus-based GVHD prophylaxis. Bone Marrow Transplant. 2011 May; 46(5):659-67. PMID: 20697368.
    Citations: 52     Fields:    Translation:Humans
  57. Rosenblatt J, Wu Z, Vasir B, Zarwan C, Stone R, Mills H, Friedman T, Konstantinopoulos PA, Spentzos D, Ghebremichael M, Stevenson K, Neuberg D, Levine JD, Joyce R, Tzachanis D, Boussiotis V, Kufe D, Avigan D. Generation of tumor-specific T lymphocytes using dendritic cell/tumor fusions and anti-CD3/CD28. J Immunother. 2010 Feb-Mar; 33(2):155-66. PMID: 20145548.
    Citations: 14     Fields:    Translation:HumansCells
  58. Brown JA, Stevenson K, Kim HT, Cutler C, Ballen K, McDonough S, Reynolds C, Herrera M, Liney D, Ho V, Kao G, Armand P, Koreth J, Alyea E, McAfee S, Attar E, Dey B, Spitzer T, Soiffer R, Ritz J, Antin JH, Boussiotis VA. Clearance of CMV viremia and survival after double umbilical cord blood transplantation in adults depends on reconstitution of thymopoiesis. Blood. 2010 May 20; 115(20):4111-9. PMID: 20107229.
    Citations: 38     Fields:    Translation:HumansCells
  59. Rosenblatt J, Bissonnette A, Ahmad R, Wu Z, Vasir B, Stevenson K, Zarwan C, Keefe W, Glotzbecker B, Mills H, Joyce R, Levine JD, Tzachanis D, Boussiotis V, Kufe D, Avigan D. Immunomodulatory effects of vitamin D: implications for GVHD. Bone Marrow Transplant. 2010 Sep; 45(9):1463-8. PMID: 20081878.
    Citations: 10     Fields:    Translation:HumansCells
  60. Patsoukis N, Lafuente EM, Meraner P, Kim Js, Dombkowski D, Li L, Boussiotis VA. RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells. Sci Signal. 2009 Dec 01; 2(99):ra79. PMID: 19952372.
    Citations: 12     Fields:    Translation:HumansCells
  61. Li L, Wang H, Kim Js, Pihan G, Boussiotis V. The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD. . 2009 Jun 01; 8(11):1794 - 1802. PMID: 19448431.
    Citations: 16     Translation:AnimalsCells
  62. Tzachanis D, Boussiotis VA. Tob, a member of the APRO family, regulates immunological quiescence and tumor suppression. . 2009 Apr 01; 8(7):1019-25. PMID: 19270514.
    Citations: 15     Translation:HumansAnimalsCells
  63. Zhou D, Medoff BD, Chen L, Li L, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20321-6. PMID: 19073936.
    Citations: 69     Fields:    Translation:AnimalsCells
  64. Cardoso BA, Martins LR, Santos CI, Nadler LM, Boussiotis VA, Cardoso AA, Barata JT. Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling. Leukemia. 2009 Jan; 23(1):206-8. PMID: 18596736.
    Citations: 8     Fields:    Translation:HumansCells
  65. Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol. 2008 Jun 30; 181(7):1211-22. PMID: 18573917.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  66. Ge X, Brown J, Sykes M, Boussiotis VA. CD134-allodepletion allows selective elimination of alloreactive human T cells without loss of virus-specific and leukemia-specific effectors. Biol Blood Marrow Transplant. 2008 May; 14(5):518-30. PMID: 18410894.
    Citations: 19     Fields:    Translation:HumansCells
  67. Friedberg J, Jacobsen E, Neuberg D, Kutok J, Munoz O, Boussiotis V, Reynolds H, Fisher D, Szot A, Van Den Abbeele A, Freedman A. Targeting the follicular lymphoma microenvironment through blockade of TNFalpha with etanercept. Leuk Lymphoma. 2008 May; 49(5):902-9. PMID: 18464109.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  68. Brown JA, Boussiotis VA. Umbilical cord blood transplantation: basic biology and clinical challenges to immune reconstitution. Clin Immunol. 2008 Jun; 127(3):286-97. PMID: 18395491.
    Citations: 40     Fields:    Translation:HumansCells
  69. Muzio M, Apollonio B, Scielzo C, Frenquelli M, Vandoni I, Boussiotis V, Caligaris-Cappio F, Ghia P. Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy. Blood. 2008 Jul 01; 112(1):188-95. PMID: 18292287.
    Citations: 80     Fields:    Translation:HumansCells
  70. Li L, Boussiotis V. Control and regulation of peripheral tolerance in allergic inflammatory disease: therapeutic consequences. Chem Immunol Allergy. 2008; 94:178-188. PMID: 18802347.
    Citations: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  71. O'Shaughnessy MJ, Chen ZM, Gramaglia I, Taylor PA, Panoskaltsis-Mortari A, Vogtenhuber C, Palmer E, Grader-Beck T, Boussiotis VA, Blazar BR. Elevation of intracellular cyclic AMP in alloreactive CD4(+) T Cells induces alloantigen-specific tolerance that can prevent GVHD lethality in vivo. Biol Blood Marrow Transplant. 2007 May; 13(5):530-42. PMID: 17448912.
    Citations: 11     Fields:    Translation:AnimalsCells
  72. Lafuente EM, Iwamoto Y, Carman CV, van Puijenbroek AA, Constantine E, Li L, Boussiotis VA. Active Rap1, a small GTPase that induces malignant transformation of hematopoietic progenitors, localizes in the nucleus and regulates protein expression. Leuk Lymphoma. 2007 May; 48(5):987-1002. PMID: 17487743.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  73. Tzachanis D, Li L, Lafuente EM, Berezovskaya A, Freeman GJ, Boussiotis VA. Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes. Blood. 2007 Apr 01; 109(7):2944-52. PMID: 17164348.
    Citations: 10     Fields:    Translation:HumansCells
  74. Li L, Iwamoto Y, Berezovskaya A, Boussiotis VA. A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance. Nat Immunol. 2006 Nov; 7(11):1157-65. PMID: 17013388.
    Citations: 43     Fields:    Translation:AnimalsCells
  75. Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil SJ, Ginsberg MH. Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr Biol. 2006 Sep 19; 16(18):1796-806. PMID: 16979556.
    Citations: 194     Fields:    Translation:HumansAnimalsCells
  76. Appleman LJ, Chernova I, Li L, Boussiotis VA. CD28 costimulation mediates transcription of SKP2 and CKS1, the substrate recognition components of SCFSkp2 ubiquitin ligase that leads p27kip1 to degradation. . 2006 Sep; 5(18):2123-9. PMID: 16969077.
    Citations: 16     Translation:HumansCells
  77. Li L, Boussiotis VA. Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications. J Mol Med (Berl). 2006 Nov; 84(11):887-99. PMID: 16972086.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  78. Lafuente E, Boussiotis VA. Rap1 regulation of RIAM and cell adhesion. Methods Enzymol. 2006; 407:345-58. PMID: 16757337.
    Citations: 7     Fields:    Translation:HumansCells
  79. Li L, Greenwald RJ, Lafuente EM, Tzachanis D, Berezovskaya A, Freeman GJ, Sharpe AH, Boussiotis VA. Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo. J Immunol. 2005 Sep 01; 175(5):3133-9. PMID: 16116203.
    Citations: 13     Fields:    Translation:AnimalsCells
  80. Li L, Godfrey WR, Porter SB, Ge Y, June CH, Blazar BR, Boussiotis VA. CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy. Blood. 2005 Nov 01; 106(9):3068-73. PMID: 16020508.
    Citations: 48     Fields:    Translation:HumansCells
  81. Barata JT, Cardoso AA, Boussiotis VA. Interleukin-7 in T-cell acute lymphoblastic leukemia: an extrinsic factor supporting leukemogenesis? Leuk Lymphoma. 2005 Apr; 46(4):483-95. PMID: 16019476.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  82. Appleman LJ, Boussiotis V. In vitro models of human T cell anergy. Curr Protoc Immunol. 2005 Mar; Chapter 7:Unit 7.36. PMID: 18432957.
    Citations:    Fields:    Translation:HumansCells
  83. Barata JT, Keenan TD, Silva A, Nadler LM, Boussiotis VA, Cardoso AA. Common gamma chain-signaling cytokines promote proliferation of T-cell acute lymphoblastic leukemia. Haematologica. 2004 Dec; 89(12):1459-67. PMID: 15590396.
    Citations: 19     Fields:    Translation:HumansCells
  84. Vassilakopoulos TP, Angelopoulou MK, Constantinou N, Karmiris T, Repoussis P, Roussou P, Siakantaris MP, Korkolopoulou P, Kyrtsonis MC, Kokoris SI, Dimopoulou MN, Variamis E, Viniou NA, Konstantopoulos K, Dimitriadou EM, Androulaki A, Patsouris E, Doussis-Anagnostopoulou IA, Panayiotidis P, Boussiotis VA, Kittas C, Pangalis GA. Development and validation of a clinical prediction rule for bone marrow involvement in patients with Hodgkin lymphoma. Blood. 2005 Mar 01; 105(5):1875-80. PMID: 15536150.
    Citations: 6     Fields:    Translation:Humans
  85. Tzachanis D, Lafuente EM, Li L, Boussiotis VA. Intrinsic and extrinsic regulation of T lymphocyte quiescence. Leuk Lymphoma. 2004 Oct; 45(10):1959-67. PMID: 15370239.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  86. Krause M, Leslie JD, Stewart M, Lafuente EM, Valderrama F, Jagannathan R, Strasser GA, Rubinson DA, Liu H, Way M, Yaffe MB, Boussiotis VA, Gertler FB. Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev Cell. 2004 Oct; 7(4):571-83. PMID: 15469845.
    Citations: 137     Fields:    Translation:HumansCells
  87. Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA. RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev Cell. 2004 Oct; 7(4):585-95. PMID: 15469846.
    Citations: 171     Fields:    Translation:HumansAnimalsCells
  88. Barata JT, Silva A, Brandao JG, Nadler LM, Cardoso AA, Boussiotis VA. Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. J Exp Med. 2004 Sep 06; 200(5):659-69. PMID: 15353558.
    Citations: 110     Fields:    Translation:HumansCells
  89. Vassilakopoulos TP, Angelopoulou MK, Siakantaris MP, Kontopidou FN, Dimopoulou MN, Kokoris SI, Kyrtsonis MC, Tsaftaridis P, Karkantaris C, Anargyrou K, Boutsis DE, Variamis E, Michalopoulos T, Boussiotis VA, Panayiotidis P, Papavassiliou C, Pangalis GA. Combination chemotherapy plus low-dose involved-field radiotherapy for early clinical stage Hodgkin's lymphoma. Int J Radiat Oncol Biol Phys. 2004 Jul 01; 59(3):765-81. PMID: 15183480.
    Citations: 2     Fields:    Translation:Humans
  90. Barata JT, Boussiotis VA, Yunes JA, Ferrando AA, Moreau LA, Veiga JP, Sallan SE, Look AT, Nadler LM, Cardoso AA. IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL. Blood. 2004 Mar 01; 103(5):1891-900. PMID: 14615384.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  91. Tzachanis D, Appleman LJ, Van Puijenbroek AA, Berezovskaya A, Nadler LM, Boussiotis VA. Differential localization and function of ADP-ribosylation factor-6 in anergic human T cells: a potential marker for their identification. J Immunol. 2003 Aug 15; 171(4):1691-6. PMID: 12902467.
    Citations: 2     Fields:    Translation:HumansCells
  92. Appleman LJ, Boussiotis VA. T cell anergy and costimulation. Immunol Rev. 2003 Apr; 192:161-80. PMID: 12670403.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  93. Grader-Beck T, van Puijenbroek AA, Nadler LM, Boussiotis VA. cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression. Blood. 2003 Feb 01; 101(3):998-1006. PMID: 12393539.
    Citations: 18     Fields:    Translation:HumansCells
  94. Appleman LJ, Tzachanis D, Grader-Beck T, Van Puijenbroek AA, Boussiotis VA. Induction of immunologic tolerance for allogeneic hematopoietic cell transplantation. Leuk Lymphoma. 2002 Jun; 43(6):1159-67. PMID: 12152983.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  95. Delgado JC, Tsai EY, Thim S, Baena A, Boussiotis VA, Reynes JM, Sath S, Grosjean P, Yunis EJ, Goldfeld AE. Antigen-specific and persistent tuberculin anergy in a cohort of pulmonary tuberculosis patients from rural Cambodia. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7576-81. PMID: 12032325.
    Citations: 30     Fields:    Translation:HumansCells
  96. Appleman LJ, van Puijenbroek AA, Shu KM, Nadler LM, Boussiotis VA. CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells. J Immunol. 2002 Mar 15; 168(6):2729-36. PMID: 11884439.
    Citations: 72     Fields:    Translation:HumansCells
  97. Tzachanis D, Berezovskaya A, Nadler LM, Boussiotis VA. Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-cell responses. Blood. 2002 Feb 15; 99(4):1465-73. PMID: 11830501.
    Citations: 15     Fields:    Translation:HumansCells
  98. Greenwald RJ, Oosterwegel MA, van der Woude D, Kubal A, Mandelbrot DA, Boussiotis VA, Sharpe AH. CTLA-4 regulates cell cycle progression during a primary immune response. Eur J Immunol. 2002 02; 32(2):366-73. PMID: 11807776.
    Citations: 34     Fields:    Translation:AnimalsCells
  99. Tzachanis D, Freeman GJ, Hirano N, van Puijenbroek AA, Delfs MW, Berezovskaya A, Nadler LM, Boussiotis VA. Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. Nat Immunol. 2001 Dec; 2(12):1174-82. PMID: 11694881.
    Citations: 94     Fields:    Translation:HumansCells
  100. Vassilakopoulos TP, Angelopoulou MK, Siakantaris MP, Kontopidou FN, Dimopoulou MN, Barbounis A, Grigorakis V, Karkantaris C, Anargyrou K, Chatziioannou M, Rombos J, Boussiotis VA, Vaiopoulos G, Kittas C, Pangalis GA. Prognostic factors in advanced stage Hodgkin's lymphoma: the significance of the number of involved anatomic sites. Eur J Haematol. 2001 Nov-Dec; 67(5-6):279-88. PMID: 11872075.
    Citations: 4     Fields:    Translation:Humans
  101. Kyrtsonis MC, Vassilakopoulos TP, Angelopoulou MK, Siakantaris P, Kontopidou FN, Dimopoulou MN, Boussiotis V, Gribabis A, Konstantopoulos K, Vaiopoulos GA, Fessas P, Kittas C, Pangalis GA. Waldenström's macroglobulinemia: clinical course and prognostic factors in 60 patients. Experience from a single hematology unit. Ann Hematol. 2001 Dec; 80(12):722-7. PMID: 11797112.
    Citations: 9     Fields:    Translation:Humans
  102. Barata JT, Cardoso AA, Nadler LM, Boussiotis VA. Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1). Blood. 2001 Sep 01; 98(5):1524-31. PMID: 11520803.
    Citations: 55     Fields:    Translation:HumansCells
  103. Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2001 Mar; 2(3):261-8. PMID: 11224527.
    Citations: 830     Fields:    Translation:HumansAnimalsCells
  104. Greenwald RJ, Boussiotis VA, Lorsbach RB, Abbas AK, Sharpe AH. CTLA-4 regulates induction of anergy in vivo. Immunity. 2001 Feb; 14(2):145-55. PMID: 11239447.
    Citations: 112     Fields:    Translation:AnimalsCells
  105. Boussiotis VA, Chen ZM, Zeller JC, Murphy WJ, Berezovskaya A, Narula S, Roncarolo MG, Blazar BR. Altered T-cell receptor + CD28-mediated signaling and blocked cell cycle progression in interleukin 10 and transforming growth factor-beta-treated alloreactive T cells that do not induce graft-versus-host disease. Blood. 2001 Jan 15; 97(2):565-71. PMID: 11154238.
    Citations: 11     Fields:    Translation:AnimalsCells
  106. Appleman LJ, Tzachanis D, Grader-Beck T, van Puijenbroek AA, Boussiotis VA. Helper T cell anergy: from biochemistry to cancer pathophysiology and therapeutics. J Mol Med (Berl). 2001; 78(12):673-83. PMID: 11434720.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  107. McAdam AJ, Chang TT, Lumelsky AE, Greenfield EA, Boussiotis VA, Duke-Cohan JS, Chernova T, Malenkovich N, Jabs C, Kuchroo VK, Ling V, Collins M, Sharpe AH, Freeman GJ. Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J Immunol. 2000 Nov 01; 165(9):5035-40. PMID: 11046032.
    Citations: 114     Fields:    Translation:AnimalsCells
  108. Boussiotis VA, Tsai EY, Yunis EJ, Thim S, Delgado JC, Dascher CC, Berezovskaya A, Rousset D, Reynes JM, Goldfeld AE. IL-10-producing T cells suppress immune responses in anergic tuberculosis patients. J Clin Invest. 2000 May; 105(9):1317-25. PMID: 10792007.
    Citations: 135     Fields:    Translation:HumansCells
  109. Boussiotis VA, Freeman GJ, Taylor PA, Berezovskaya A, Grass I, Blazar BR, Nadler LM. p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes. Nat Med. 2000 Mar; 6(3):290-7. PMID: 10700231.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  110. Angelopoulou MK, Vassilakopoulos TP, Siakantaris MP, Kontopidou FN, Boussiotis VA, Papavassiliou C, Kittas C, Pangalis GA. EBVD combination chemotherapy plus low dose involved field radiation is a highly effective treatment modality for early stage Hodgkin's disease. Leuk Lymphoma. 2000 Mar; 37(1-2):131-43. PMID: 10721777.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  111. Appleman LJ, Berezovskaya A, Grass I, Boussiotis VA. CD28 costimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression. J Immunol. 2000 Jan 01; 164(1):144-51. PMID: 10605005.
    Citations: 50     Fields:    Translation:HumansCells
  112. Guinan EC, Boussiotis VA, Neuberg D, Brennan LL, Hirano N, Nadler LM, Gribben JG. Transplantation of anergic histoincompatible bone marrow allografts. N Engl J Med. 1999 Jun 03; 340(22):1704-14. PMID: 10352162.
    Citations: 76     Fields:    Translation:HumansCellsCTClinical Trials
  113. Boussiotis VA, Freedman AS, Nadler LM. Bone marrow transplantation for low-grade lymphoma and chronic lymphocytic leukemia. Semin Hematol. 1999 Apr; 36(2):209-16. PMID: 10319389.
    Citations: 2     Fields:    Translation:Humans
  114. Boussiotis VA, Freeman GJ, Gribben JG, Hayes DF, Nadler LM. No evidence for MUC 1-induced apoptosis. Nat Med. 1998 Oct; 4(10):1093. PMID: 9771724.
    Citations: 1     Fields:    Translation:Cells
  115. Freeman GJ, Cardoso AA, Boussiotis VA, Anumanthan A, Groves RW, Kupper TS, Clark EA, Nadler LM. The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor. J Immunol. 1998 Sep 15; 161(6):2708-15. PMID: 9743327.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  116. Ghia P, Boussiotis VA, Schultze JL, Cardoso AA, Dorfman DM, Gribben JG, Freedman AS, Nadler LM. Unbalanced expression of bcl-2 family proteins in follicular lymphoma: contribution of CD40 signaling in promoting survival. Blood. 1998 Jan 01; 91(1):244-51. PMID: 9414291.
    Citations: 20     Fields:    Translation:HumansCells
  117. Boussiotis VA, Freeman GJ, Berezovskaya A, Barber DL, Nadler LM. Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science. 1997 Oct 03; 278(5335):124-8. PMID: 9311917.
    Citations: 94     Fields:    Translation:HumansCells
  118. Boussiotis VA, Lee BJ, Freeman GJ, Gribben JG, Nadler LM. Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death. J Immunol. 1997 Oct 01; 159(7):3156-67. PMID: 9317113.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  119. Cardoso AA, Seamon MJ, Afonso HM, Ghia P, Boussiotis VA, Freeman GJ, Gribben JG, Sallan SE, Nadler LM. Ex vivo generation of human anti-pre-B leukemia-specific autologous cytolytic T cells. Blood. 1997 Jul 15; 90(2):549-61. PMID: 9226154.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  120. Gimmi CD, Morrison BW, Mainprice BA, Gribben JG, Boussiotis VA, Freeman GJ, Park SY, Watanabe M, Gong J, Hayes DF, Kufe DW, Nadler LM. Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells. Nat Med. 1996 Dec; 2(12):1367-70. PMID: 8946837.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  121. Hall KT, Boumsell L, Schultze JL, Boussiotis VA, Dorfman DM, Cardoso AA, Bensussan A, Nadler LM, Freeman GJ. Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11780-5. PMID: 8876214.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  122. Boussiotis VA, Freeman GJ, Gribben JG, Nadler LM. The role of B7-1/B7-2:CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response. Immunol Rev. 1996 Oct; 153:5-26. PMID: 9010717.
    Citations: 33     Fields:    Translation:Cells
  123. Boussiotis VA, Pardo NA, Collins H, Houghton A, Ritz J, Nadler LM, Soiffer RJ. R24 anti-GD3 ganglioside antibody can induce costimulation and prevent the induction of alloantigen-specific T cell clonal anergy. Eur J Immunol. 1996 Sep; 26(9):2149-54. PMID: 8814260.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  124. Boussiotis VA, Barber DL, Lee BJ, Gribben JG, Freeman GJ, Nadler LM. Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation. J Exp Med. 1996 Aug 01; 184(2):365-76. PMID: 8760790.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  125. Cardoso AA, Schultze JL, Boussiotis VA, Freeman GJ, Seamon MJ, Laszlo S, Billet A, Sallan SE, Gribben JG, Nadler LM. Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen. Blood. 1996 Jul 01; 88(1):41-8. PMID: 8704200.
    Citations: 33     Fields:    Translation:HumansCells
  126. Gribben JG, Guinan EC, Boussiotis VA, Ke XY, Linsley L, Sieff C, Gray GS, Freeman GJ, Nadler LM. Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft-versus-host disease and extend the donor pool. Blood. 1996 Jun 01; 87(11):4887-93. PMID: 8639863.
    Citations: 19     Fields:    Translation:HumansCells
  127. Angelopoulou MA, Poziopoulos C, Boussiotis VA, Kontopidou F, Pangalis GA. Fludarabine monophosphate in refractory B-chronic lymphocytic leukemia: maintenance may be significant to sustain response. Leuk Lymphoma. 1996 Apr; 21(3-4):321-4. PMID: 8726414.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  128. Souliotis VL, Valavanis C, Boussiotis VA, Pangalis GA, Kyrtopoulos SA. Comparative study of the formation and repair of O6-methylguanine in humans and rodents treated with dacarbazine. Carcinogenesis. 1996 Apr; 17(4):725-32. PMID: 8625483.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  129. Freeman GJ, Boussiotis VA, Anumanthan A, Bernstein GM, Ke XY, Rennert PD, Gray GS, Gribben JG, Nadler LM. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity. 1995 May; 2(5):523-32. PMID: 7538442.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  130. Boussiotis VA, Freeman GJ, Gribben JG, Nadler LM. The critical role of CD28 signalling in the prevention of human T-cell anergy. Res Immunol. 1995 Mar-Apr; 146(3):140-9. PMID: 8525043.
    Citations: 3     Fields:    Translation:HumansCells
  131. Gribben JG, Freeman GJ, Boussiotis VA, Rennert P, Jellis CL, Greenfield E, Barber M, Restivo VA, Ke X, Gray GS, et al. CTLA4 mediates antigen-specific apoptosis of human T cells. Proc Natl Acad Sci U S A. 1995 Jan 31; 92(3):811-5. PMID: 7846057.
    Citations: 66     Fields:    Translation:HumansCells
  132. Guinan EC, Gribben JG, Boussiotis VA, Freeman GJ, Nadler LM. Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity. Blood. 1994 Nov 15; 84(10):3261-82. PMID: 7524733.
    Citations: 42     Fields:    Translation:HumansCells
  133. Boussiotis VA, Barber DL, Nakarai T, Freeman GJ, Gribben JG, Bernstein GM, D'Andrea AD, Ritz J, Nadler LM. Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor. Science. 1994 Nov 11; 266(5187):1039-42. PMID: 7973657.
    Citations: 81     Fields:    Translation:HumansCells
  134. Boussiotis VA, Freeman GJ, Griffin JD, Gray GS, Gribben JG, Nadler LM. CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy. J Exp Med. 1994 Nov 01; 180(5):1665-73. PMID: 7525835.
    Citations: 24     Fields:    Translation:HumansCells
  135. Boussiotis VA, Gribben JG, Freeman GJ, Nadler LM. Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance. Curr Opin Immunol. 1994 Oct; 6(5):797-807. PMID: 7530013.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  136. Souliotis VL, Valavanis C, Boussiotis VA, Pangalis GA, Kyrtopoulos SA. Comparative dosimetry of O6-methylguanine in humans and rodents treated with procarbazine. Carcinogenesis. 1994 Aug; 15(8):1675-80. PMID: 8055650.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  137. Kourtis AP, Boussiotis VA, Lymberi P, Pangalis GA. Increased natural antibody activity in sera of patients with malignant non-Hodgkin's lymphomas containing paraproteins. Am J Hematol. 1994 Aug; 46(4):283-8. PMID: 8037178.
    Citations: 1     Fields:    Translation:Humans
  138. Boussiotis VA, Nadler LM, Strominger JL, Goldfeld AE. Tumor necrosis factor alpha is an autocrine growth factor for normal human B cells. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7007-11. PMID: 7518925.
    Citations: 35     Fields:    Translation:HumansCells
  139. Korkolopoulou P, Pangalis GA, Patsouris E, Boussiotis VA, Kittas C. B-cell lymphoma of large multilobated type: an immunohistochemical study of 8 cases and review of the literature. Leuk Lymphoma. 1994 Mar; 13(1-2):151-9. PMID: 8025516.
    Citations:    Fields:    Translation:Humans
  140. Gribabis DA, Panayiotidis P, Boussiotis VA, Hannoun C, Pangalis GA. Influenza virus vaccine in B-cell chronic lymphocytic leukaemia patients. Acta Haematol. 1994; 91(3):115-8. PMID: 8091931.
    Citations: 11     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
  141. Salles G, Zain M, Jiang WM, Boussiotis VA, Shipp MA. Alternatively spliced CD44 transcripts in diffuse large-cell lymphomas: characterization and comparison with normal activated B cells and epithelial malignancies. Blood. 1993 Dec 15; 82(12):3539-47. PMID: 7505117.
    Citations: 15     Fields:    Translation:HumansCells
  142. Pangalis GA, Vassilakopoulos TP, Boussiotis VA, Fessas P. Clinical approach to lymphadenopathy. Semin Oncol. 1993 Dec; 20(6):570-82. PMID: 8296196.
    Citations: 11     Fields:    Translation:Humans
  143. Boussiotis VA, Freeman GJ, Gribben JG, Daley J, Gray G, Nadler LM. Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation. Proc Natl Acad Sci U S A. 1993 Dec 01; 90(23):11059-63. PMID: 7504293.
    Citations: 50     Fields:    Translation:HumansCells
  144. Freeman GJ, Gribben JG, Boussiotis VA, Ng JW, Restivo VA, Lombard LA, Gray GS, Nadler LM. Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science. 1993 Nov 05; 262(5135):909-11. PMID: 7694363.
    Citations: 191     Fields:    Translation:HumansAnimalsCells
  145. Boussiotis VA, Freeman GJ, Gray G, Gribben J, Nadler LM. B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance. J Exp Med. 1993 Nov 01; 178(5):1753-63. PMID: 7901318.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  146. Pangalis GA, Boussiotis VA, Kittas C. Malignant disorders of small lymphocytes. Small lymphocytic lymphoma, lymphoplasmacytic lymphoma, and chronic lymphocytic leukemia: their clinical and laboratory relationship. Am J Clin Pathol. 1993 Apr; 99(4):402-8. PMID: 8475906.
    Citations: 2     Fields:    Translation:HumansCells
  147. Kyrtopoulos SA, Souliotis VL, Valavanis C, Boussiotis VA, Pangalis GA. Accumulation of O6-methylguanine in human DNA after therapeutic exposure to methylating agents and its relationship with biological effects. Environ Health Perspect. 1993 Mar; 99:143-7. PMID: 8319612.
    Citations: 2     Fields:    Translation:HumansAnimals
  148. Goldfeld AE, Flemington EK, Boussiotis VA, Theodos CM, Titus RG, Strominger JL, Speck SH. Transcription of the tumor necrosis factor alpha gene is rapidly induced by anti-immunoglobulin and blocked by cyclosporin A and FK506 in human B cells. Proc Natl Acad Sci U S A. 1992 Dec 15; 89(24):12198-201. PMID: 1281550.
    Citations: 18     Fields:    Translation:HumansCells
  149. Boussiotis VA, Pangalis GA. Interferon alfa-2b therapy in untreated early stage, B-chronic lymphocytic leukaemia patients: one-year follow-up. Br J Haematol. 1991 Oct; 79 Suppl 1:30-3. PMID: 1931705.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  150. Pangalis GA, Boussiotis VA, Kittas C, Panayiotidis PG, Loukopoulos D, Fessas P, Mitsoulis-Mentzikoff C. Hairy cell leukemia: splenectomy after alpha 2b-interferon therapy. Blood. 1991 Sep 01; 78(5):1385. PMID: 1878598.
    Citations:    Fields:    Translation:Humans
  151. Souliotis VL, Boussiotis VA, Pangalis GA, Kyrtopoulos SA. In vivo formation and repair of O6-methylguanine in human leukocyte DNA after intravenous exposure to dacarbazine. Carcinogenesis. 1991 Feb; 12(2):285-8. PMID: 1704822.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  152. Yataganas X, Meletis J, Plata E, Viniou N, Deligiannis F, Tsekoura C, Voscaridou E, Boussiotis V, Rombos J, Vayopoulos G, et al. alpha Interferon treatment of essential thrombocythaemia and other myeloproliferative disorders with excessive thrombocytosis. Eur J Cancer. 1991; 27 Suppl 4:S69-71. PMID: 1799484.
    Citations: 1     Fields:    Translation:Humans
  153. Boussiotis VA, Pangalis GA. Interferon alfa-2b in stage A untreated B-chronic lymphocytic leukaemia patients. Eur J Cancer. 1991; 27 Suppl 4:S78-9. PMID: 1799487.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  154. Lugassy G, Boussiotis VA, Ruchlemer R, Pangalis GA, Berrebi A, Polliack A. Chronic Lymphocytic Leukemia in Young Adults: Report of Six Cases Under the Age of 30 Years. Leuk Lymphoma. 1991; 5 Suppl 1:179-82. PMID: 27463503.
    Citations: 1     Fields:    
  155. Boussiotis VA, Panayiotidis PG, Pangalis GA. Prolonged Intermittent Chlorambucil Administration in B-Chronic Lymphocytic Leukemia: Experience from a Single Hematology Unit. Leuk Lymphoma. 1991; 5 Suppl 1:113-7. PMID: 27463491.
    Citations: 2     Fields:    
  156. Kourtis A, Pangalis GA, Borche L, Boussiotis VA, Dighiero G, Lymberi P. Monoclonal and/or Oligoclonal Immunoglobulins in Sera of Patients with Non-Hodgkin's Lymphomas, Determined by Iso-Electric Focusing and Immunoblotting. Leuk Lymphoma. 1991; 5(4):255-62. PMID: 27467848.
    Citations:    Fields:    
  157. Pangalis GA, Reverter JC, Boussiotis VA, Montserrat E. Chronic Lymphocytic Leukemia in Younger Adults: Preliminary Results of a Study Based on 454 Patients-IWCLL/Working Group. Leuk Lymphoma. 1991; 5 Suppl 1:175-8. PMID: 27463502.
    Citations:    Fields:    
  158. Souliotis VL, Kaila S, Boussiotis VA, Pangalis GA, Kyrtopoulos SA. Accumulation of O6-methylguanine in human blood leukocyte DNA during exposure to procarbazine and its relationships with dose and repair. Cancer Res. 1990 May 01; 50(9):2759-64. PMID: 2328502.
    Citations: 11     Fields:    Translation:HumansCells
  159. Panaytotidis PG, Boussiotis VA, Pangallis GA. Immunologic Findings in B-Chronic Lymphocytic Leukemia Patients Treated with a2b-Interferon. Leuk Lymphoma. 1990; 1(3-4):235-40. PMID: 27463991.
    Citations: 1     Fields:    
  160. Kittas C, Korkolopoulou P, Pangalis GA, Tsenga A, Boussiotis VA, Spandidos DA. Expression of c-myc p62 Protein in Non-Hodgkin's Lymphomas. Leuk Lymphoma. 1990; 1(3-4):241-7. PMID: 27463992.
    Citations:    Fields:    
  161. Boussiotis VA, Pangalis GA. Randomized clinical trial with alpha 2b-interferon in 26 stage A untreated B-chronic lymphocytic leukemia patients. Nouv Rev Fr Hematol. 1988; 30(5-6):471-3. PMID: 3065744.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  162. Pangalis GA, Boussiotis VA, Kittas C. B-chronic lymphocytic leukemia. Disease progression in 150 untreated stage A and B patients as predicted by bone marrow pattern. Nouv Rev Fr Hematol. 1988; 30(5-6):373-5. PMID: 3222147.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.