Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
The Harvard Catalyst website will be unavailable due to system maintenance Saturday, April 30, 10am to 12pm.
Keywords
Last Name
Institution

profileVicki Rosen, Ph.D.

TitleProfessor of Developmental Biology
InstitutionHarvard School of Dental Medicine
DepartmentDevelopmental Biology
AddressHarvard School of Dental Medicine
Developmental Biology, REB-510
188 Longwood Ave
Boston MA 02115
Phone617/432-5910
Fax617/432-3246
vCardDownload vCard (login for email)
Other Positions
TitleHead of the Department of Developmental Biology
InstitutionHarvard School of Dental Medicine
DepartmentDevelopmental Biology


Collapse Mentoring 
Collapse completed student projects
Analysis of Gene Expression in the Menisci of Fetal Mice
Summer, 04/01/02 - 08/31/02
The Role of BMP-2 in Osteoprogenitor and Osteoblast Differentiation
Summer, 06/19/06 - 08/18/06

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Salazar VS, Gamer LW, Rosen V. BMP signalling in skeletal development, disease and repair. Nat Rev Endocrinol. 2016 Apr; 12(4):203-21. PMID: 26893264.
    View in: PubMed
  2. Wang J, Yu T, Wang Z, Ohte S, Yao RE, Zheng Z, Geng J, Cai H, Ge Y, Li Y, Xu Y, Zhang Q, Gusella JF, Fu Q, Pregizer S, Rosen V, Shen Y. A New Subtype of Multiple Synostoses Syndrome Is Caused by a Mutation in GDF6 That Decreases Its Sensitivity to Noggin and Enhances Its Potency as a BMP Signal. J Bone Miner Res. 2016 Apr; 31(4):882-9. PMID: 26643732.
    View in: PubMed
  3. Abula K, Muneta T, Miyatake K, Yamada J, Matsukura Y, Inoue M, Sekiya I, Graf D, Economides AN, Rosen V, Tsuji K. Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age. FEBS Lett. 2015 May 8; 589(11):1240-8. PMID: 25889639.
    View in: PubMed
  4. Li Q, Doyran B, Gamer LW, Lu XL, Qin L, Ortiz C, Grodzinsky AJ, Rosen V, Han L. Biomechanical properties of murine meniscus surface via AFM-based nanoindentation. J Biomech. 2015 Jun 1; 48(8):1364-70. PMID: 25817332; PMCID: PMC4442049 [Available on 06/01/16].
  5. Lowery JW, Intini G, Gamer L, Lotinun S, Salazar VS, Ote S, Cox K, Baron R, Rosen V. Loss of BMPR2 leads to high bone mass due to increased osteoblast activity. J Cell Sci. 2015 Apr 1; 128(7):1308-15. PMID: 25663702; PMCID: PMC4379725 [Available on 04/01/16].
  6. Chim SM, Kuek V, Chow ST, Lim BS, Tickner J, Zhao J, Chung R, Su YW, Zhang G, Erber W, Xian CJ, Rosen V, Xu J. EGFL7 is expressed in bone microenvironment and promotes angiogenesis via ERK, STAT3, and integrin signaling cascades. J Cell Physiol. 2015 Jan; 230(1):82-94. PMID: 24909139.
    View in: PubMed
  7. Muhammad H, Schminke B, Bode C, Roth M, Albert J, von der Heyde S, Rosen V, Miosge N. Human migratory meniscus progenitor cells are controlled via the TGF-ß pathway. Stem Cell Reports. 2014 Nov 11; 3(5):789-803. PMID: 25418724; PMCID: PMC4235742.
  8. McBride SH, McKenzie JA, Bedrick BS, Kuhlmann P, Pasteris JD, Rosen V, Silva MJ. Long bone structure and strength depend on BMP2 from osteoblasts and osteocytes, but not vascular endothelial cells. PLoS One. 2014; 9(5):e96862. PMID: 24837969; PMCID: PMC4024030.
  9. Kokabu S, Sato T, Ohte S, Enoki Y, Okubo M, Hayashi N, Nojima J, Tsukamoto S, Fukushima Y, Sakata Y, Katagiri T, Rosen V, Yoda T. Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling. FEBS Lett. 2014 Feb 14; 588(4):614-9. PMID: 24444608.
    View in: PubMed
  10. Lowery JW, Amich JM, Andonian A, Rosen V. N-linked glycosylation of the bone morphogenetic protein receptor type 2 (BMPR2) enhances ligand binding. Cell Mol Life Sci. 2014 Aug; 71(16):3165-72. PMID: 24337809; PMCID: PMC4058410.
  11. Wu X, Chim SM, Kuek V, Lim BS, Chow ST, Zhao J, Yang S, Rosen V, Tickner J, Xu J. HtrA1 is upregulated during RANKL-induced osteoclastogenesis, and negatively regulates osteoblast differentiation and BMP2-induced Smad1/5/8, ERK and p38 phosphorylation. FEBS Lett. 2014 Jan 3; 588(1):143-50. PMID: 24269886.
    View in: PubMed
  12. Pazin DE, Gamer LW, Capelo LP, Cox KA, Rosen V. Gene signature of the embryonic meniscus. J Orthop Res. 2014 Jan; 32(1):46-53. PMID: 24108661.
    View in: PubMed
  13. Schminke B, Muhammad H, Bode C, Sadowski B, Gerter R, Gersdorff N, Bürgers R, Monsonego-Ornan E, Rosen V, Miosge N. A discoidin domain receptor 1 knock-out mouse as a novel model for osteoarthritis of the temporomandibular joint. Cell Mol Life Sci. 2014 Mar; 71(6):1081-96. PMID: 23912900.
    View in: PubMed
  14. Kokabu S, Nguyen T, Ohte S, Sato T, Katagiri T, Yoda T, Rosen V. TLE3, transducing-like enhancer of split 3, suppresses osteoblast differentiation of bone marrow stromal cells. Biochem Biophys Res Commun. 2013 Aug 16; 438(1):205-10. PMID: 23880346.
    View in: PubMed
  15. Whitman M, Rosen V, Brivanlou AH, Groppe JC, Sebald W, Mueller T. Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3. Nat Med. 2013 Jul; 19(7):809-10. PMID: 23836213.
    View in: PubMed
  16. Chim SM, Tickner J, Chow ST, Kuek V, Guo B, Zhang G, Rosen V, Erber W, Xu J. Angiogenic factors in bone local environment. Cytokine Growth Factor Rev. 2013 Jun; 24(3):297-310. PMID: 23611723.
    View in: PubMed
  17. Lowery JW, Lavigne AW, Kokabu S, Rosen V. Comparative genomics identifies the mouse Bmp3 promoter and an upstream evolutionary conserved region (ECR) in mammals. PLoS One. 2013; 8(2):e57840. PMID: 23451274; PMCID: PMC3579780.
  18. Pazin DE, Gamer LW, Cox KA, Rosen V. Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow. Dev Dyn. 2012 Nov; 241(11):1816-26. PMID: 22972626.
    View in: PubMed
  19. Chappuis V, Gamer L, Cox K, Lowery JW, Bosshardt DD, Rosen V. Periosteal BMP2 activity drives bone graft healing. Bone. 2012 Oct; 51(4):800-9. PMID: 22846673.
    View in: PubMed
  20. Lowery JW, Rosen V. Allele-specific RNA interference in FOP silencing the FOP gene. Gene Ther. 2012 Jul; 19(7):701-2. PMID: 22130446.
    View in: PubMed
  21. Kokabu S, Gamer L, Cox K, Lowery J, Tsuji K, Raz R, Economides A, Katagiri T, Rosen V. BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b. Mol Endocrinol. 2012 Jan; 26(1):87-94. PMID: 22074949; PMCID: PMC3248326.
  22. Rosen V. Harnessing the parathyroid hormone, Wnt, and bone morphogenetic protein signaling cascades for successful bone tissue engineering. Tissue Eng Part B Rev. 2011 Dec; 17(6):475-9. PMID: 21902616.
    View in: PubMed
  23. Gamer LW, Tsuji K, Cox K, Capelo LP, Lowery J, Beppu H, Rosen V. BMPR-II is dispensable for formation of the limb skeleton. Genesis. 2011 Sep; 49(9):719-24. PMID: 21538804.
    View in: PubMed
  24. Lowery JW, Pazin D, Intini G, Kokabu S, Chappuis V, Capelo LP, Rosen V. The role of BMP2 signaling in the skeleton. Crit Rev Eukaryot Gene Expr. 2011; 21(2):177-85. PMID: 22077155.
    View in: PubMed
  25. Tsuji K, Cox K, Gamer L, Graf D, Economides A, Rosen V. Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repair. J Orthop Res. 2010 Mar; 28(3):384-9. PMID: 19780203; PMCID: PMC2862367.
  26. Stankovic KM, Adachi O, Tsuji K, Kristiansen AG, Adams JC, Rosen V, McKenna MJ. Differences in gene expression between the otic capsule and other bones. Hear Res. 2010 Jun 14; 265(1-2):83-9. PMID: 20146935; PMCID: PMC3586807.
  27. Alam N, St-Arnaud R, Lauzier D, Rosen V, Hamdy RC. Are endogenous BMPs necessary for bone healing during distraction osteogenesis? Clin Orthop Relat Res. 2009 Dec; 467(12):3190-8. PMID: 19760469; PMCID: PMC2772912.
  28. Rosen V. BMP2 signaling in bone development and repair. Cytokine Growth Factor Rev. 2009 Oct-Dec; 20(5-6):475-80. PMID: 19892583.
    View in: PubMed
  29. Gamer LW, Cox K, Carlo JM, Rosen V. Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fractures. Dev Dyn. 2009 Sep; 238(9):2374-81. PMID: 19653325; PMCID: PMC3523674.
  30. Gamer LW, Ho V, Cox K, Rosen V. Expression and function of BMP3 during chick limb development. Dev Dyn. 2008 Jun; 237(6):1691-8. PMID: 18489005; PMCID: PMC2862365.
  31. Tsuji K, Cox K, Bandyopadhyay A, Harfe BD, Tabin CJ, Rosen V. BMP4 is dispensable for skeletogenesis and fracture-healing in the limb. J Bone Joint Surg Am. 2008 Feb; 90 Suppl 1:14-8. PMID: 18292351.
    View in: PubMed
  32. Tsuji K, Bandyopadhyay A, Harfe BD, Cox K, Kakar S, Gerstenfeld L, Einhorn T, Tabin CJ, Rosen V. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet. 2006 Dec; 38(12):1424-9. PMID: 17099713.
    View in: PubMed
  33. Bandyopadhyay A, Tsuji K, Cox K, Harfe BD, Rosen V, Tabin CJ. Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Genet. 2006 Dec; 2(12):e216. PMID: 17194222; PMCID: PMC1713256.
  34. L.Gamer, V. Rosen. BMP3 Signaling in the Formation and Regulation of Bone. CellScience. 2006; 3(2):58-67.
  35. Chen H, Yong W, Ren S, Shen W, He Y, Cox KA, Zhu W, Li W, Soonpaa M, Payne RM, Franco D, Field LJ, Rosen V, Wang Y, Shou W. Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth. J Biol Chem. 2006 Sep 15; 281(37):27481-91. PMID: 16798733; PMCID: PMC2628764.
  36. Rosen V. BMP and BMP inhibitors in bone. Ann N Y Acad Sci. 2006 Apr; 1068:19-25. PMID: 16831902.
    View in: PubMed
  37. Gamer LW, Nove J, Levin M, Rosen V. BMP-3 is a novel inhibitor of both activin and BMP-4 signaling in Xenopus embryos. Dev Biol. 2005 Sep 1; 285(1):156-68. PMID: 16054124.
    View in: PubMed
  38. Gamer LW, Nove J, Rosen V. Return of the chalones. Dev Cell. 2003 Feb; 4(2):143-4. PMID: 12586054.
    View in: PubMed
  39. Thomopoulos S, Hattersley G, Rosen V, Mertens M, Galatz L, Williams GR, Soslowsky LJ. The localized expression of extracellular matrix components in healing tendon insertion sites: an in situ hybridization study. J Orthop Res. 2002 May; 20(3):454-63. PMID: 12038618.
    View in: PubMed
  40. Porter AE, Hobbs LW, Rosen VB, Spector M. The ultrastructure of the plasma-sprayed hydroxyapatite-bone interface predisposing to bone bonding. Biomaterials. 2002 Feb; 23(3):725-33. PMID: 11771693.
    View in: PubMed
  41. Rosen VB, Hobbs LW, Spector M. The ultrastructure of anorganic bovine bone and selected synthetic hyroxyapatites used as bone graft substitute materials. Biomaterials. 2002 Feb; 23(3):921-8. PMID: 11771712.
    View in: PubMed
  42. Wang E, Wozney JM, Rosen V, inventors;. Bone Morphogenetic Protein-3 and Compositions. 2002.
  43. Schweitzer R, Chyung JH, Murtaugh LC, Brent AE, Rosen V, Olson EN, Lassar A, Tabin CJ. Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments. Development. 2001 Oct; 128(19):3855-66. PMID: 11585810.
    View in: PubMed
  44. Gamer LW, Cox KA, Small C, Rosen V. Gdf11 is a negative regulator of chondrogenesis and myogenesis in the developing chick limb. Dev Biol. 2001 Jan 15; 229(2):407-20. PMID: 11203700.
    View in: PubMed
  45. Wozney JM, Celeste AJ, Rosen V, inventors;. BMP-9 Compositions. 2001.
  46. Dailuski A, Engstrand T, Bahamonde M, Tompkinson K, Gamer LW, Rosen V, and Lyons KM. . BMP3 is a negative regulator of bone density. Nature Genet. 2001; 27:84-88.
  47. Wang E, Wozney JM, Rosen V, inventors;. BMP-3 Products. 2001.
  48. Banerjee C, Javed A, Choi J-Y, Green J, Rosen V, van Wijnen AJ, Stein JL, Lian JB, and Stein GS. Differential regulation of the two principal RunX/Cbfa1 N-terminal isoforms in response to BMP-2 during development of the osteoblast phenotype. Endocrinol. 2001; 142:4026-4039.
  49. Weston AD, Rosen V, Chandraratna RA, Underhill TM. Regulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathways. J Cell Biol. 2000 Feb 21; 148(4):679-90. PMID: 10684250; PMCID: PMC2169377.
  50. Ladher RK, Church VL, Allen S, Robson L, Abdelfattah A, Brown NA, Hattersley G, Rosen V, Luyten FP, Dale L, Francis-West PH. Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick development. Dev Biol. 2000 Feb 15; 218(2):183-98. PMID: 10656762.
    View in: PubMed
  51. Yi SE, Daluiski A, Pederson R, Rosen V, Lyons KM. The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development. 2000 Feb; 127(3):621-30. PMID: 10631182.
    View in: PubMed
  52. Celeste AJ, Wozney JM, Rosen V, Wofman N, Thomsen GH, Melton DA, inventors;. BMP-12 and BMP-13 Proteins and DNA Encoding Them. 2000.
  53. Rosen V, Wozney JM, Celeste AJ, Thies RS, Song JJ, inventors;. BMP-9 Compositions. 2000.
  54. Valcourt U, Ronzière MC, Winkler P, Rosen V, Herbage D, Mallein-Gerin F. Different effects of bone morphogenetic proteins 2, 4, 12, and 13 on the expression of cartilage and bone markers in the MC615 chondrocyte cell line. Exp Cell Res. 1999 Sep 15; 251(2):264-74. PMID: 10471312.
    View in: PubMed
  55. Lee MH, Javed A, Kim HJ, Shin HI, Gutierrez S, Choi JY, Rosen V, Stein JL, van Wijnen AJ, Stein GS, Lian JB, Ryoo HM. Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation. J Cell Biochem. 1999 Apr 1; 73(1):114-25. PMID: 10088730.
    View in: PubMed
  56. Gamer LW, Wolfman NM, Celeste AJ, Hattersley G, Hewick R, Rosen V. A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos. Dev Biol. 1999 Apr 1; 208(1):222-32. PMID: 10075854.
    View in: PubMed
  57. Neuhaus H, Rosen V, Thies RS. Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily. Mech Dev. 1999 Feb; 80(2):181-4. PMID: 10072785.
    View in: PubMed
  58. Furuya K, Nifuji A, Rosen V, Noda M. Effects of GDF7/BMP12 on proliferation and alkaline phosphatase expression in rat osteoblastic osteosarcoma ROS 17/2.8 cells. J Cell Biochem. 1999 Feb 1; 72(2):177-80. PMID: 10022500.
    View in: PubMed
  59. Gamer L, and Rosen V. Molecular Genetics of Skeletal Morphogenesis. Osteoporosis: Genetics, Prevention and Treatment, J. Adams and B. Lukert, eds. 1999; 7-23.
  60. Hattersley G, Wolfman N, Morris E, Rosen V, inventors;. Cartilage Induction by Bone Morphogenetic Proteins. 1999.
  61. Chen D, Ji X, Harris MA, Feng JQ, Karsenty G, Celeste AJ, Rosen V, Mundy GR, Harris SE. Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages. J Cell Biol. 1998 Jul 13; 142(1):295-305. PMID: 9660882; PMCID: PMC2133031.
  62. Wozney JM, Rosen V. Bone morphogenetic proteinn and bone morphogenetic protein gene family in bone formation and repair. Clin Orthop Rel Res. 1998; 346:26-37.
  63. Wozney JM, Wang E, Rosen V, inventors;. Bone Morphogenetic Protein-6 and DNA Encoding Same. 1998.
  64. Lanchoney TF, Olmsted EA, Shore EM, Gannon FA, Rosen V, Zasloff MA, Kaplan FS. Characterization of bone morphogenetic protein 4 receptor in fibrodysplasia ossificans progressiva. Clin Orthop Relat Res. 1998 Jan; (346):38-45. PMID: 9577408.
    View in: PubMed
  65. Wang EA, Rosen V, Cordes P, Hewick RM, Kriz MJ, Luxenberg DP, Sibley BS, and Wozney JM. Purification and characterization of other distinct bone inducing factors. PNAS USA. 1998; 87:2220-2224.
  66. Centrella M, Rosen V, Wozney JM, Casinghino SR, McCarthy TL. Opposing effects by glucocorticoid and bone morphogenetic protein-2 in fetal rat bone cell cultures. J Cell Biochem. 1997 Dec 15; 67(4):528-40. PMID: 9383711.
    View in: PubMed
  67. Wang E, Wozney JM, Rosen V, inventors; . Compositions Comprising BMP-2. 1997.
  68. Katagiri T, Akiyama S, Namiki M, Komaki M, Yamaguchi A, Rosen V, Wozney JM, Fujisawa-Sehara A, Suda T. Bone morphogenetic protein-2 inhibits terminal differentiation of myogenic cells by suppressing the transcriptional activity of MyoD and myogenin. Exp Cell Res. 1997 Feb 1; 230(2):342-51. PMID: 9024793.
    View in: PubMed
  69. Wolfman NM, Hattersley G, Celeste AJ, Nelson R, Yamaji N, Dube JL, Diblasio-Smith E, Nove J, Song JJ, Wozney JM, and Rosen V. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5,6 and 7, members of the TGF-B gene family. J Clin Investig. 1997; 100:1-10.
  70. Celeste AJ, Wozney JM, Rosen V, Wolfman N, Thomsen GH, Melton DA, inventors;. Methods of Inducing Formation of Tendon and/or Ligament Tissue Comprising. 1997.
  71. Namiki M, Akiyama S, Katagiri T, Suzuki A, Ueno N, Yamaji N, Rosen V, Wozney JM, and Suda T. A kinase domain-trunacted type I receptor blocks bone morphogenetic proetin-2-induced signal transduction in C2C12 myoblasts. J Biol Chen. 1997; 272:22046-22052.
  72. Wang E, Wozney JM, Rosen V, inventors;. BMP-2 Products. 1997.
  73. Wozney JM, Rosen V, Wang E, inventors;. Bone Morphogenentic Protein-5 and DNA Encoding Same. 1997.
  74. Wozney JM, Rosen V, Wang E, inventors;. Methods of Administering BMP-5 Compositions. 1997.
  75. Hattersley G, Rosen V, inventors;. Compositions Comprising Bone Morphogenetic Proteins and Truncated Parathyroid Hormon Related Peptide, and Methods of Inducing Cartilage by Administration of Same. 1997.
  76. An J, Rosen V, Cox K, Beauchemin N, Sullivan AK. Recombinant human bone morphogenetic protein-2 induces a hematopoietic microenvironment in the rat that supports the growth of stem cells. Exp Hematol. 1996 Jun; 24(7):768-75. PMID: 8647226.
    View in: PubMed
  77. Israel DI, Nove J, Kerns KM, Kaufman RJ, Rosen V, Cox KA, Wozney JM. Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo. Growth Factors. 1996; 13(3-4):291-300. PMID: 8919035.
    View in: PubMed
  78. Rosen V, Thies RS, and Lyons KM. Signaling pathways in skeletal formation: A role for BMP receptors. Molecular and Developmental Biology of Cartilage,. 1996; 785:661-671.
  79. Yamaguchi A, Ishizuya T, Kintou N, Wada Y, Katagiri T, Wozney JM, Rosen V, and Yoshiki S. Effects of BMP-2, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines ST2 and MC3T3-G2/PA6. Biochem Biophy Res Commun. 1996; 220:366-371.
  80. Fleet JC, Cashman K, Cox K, and Rosen V. The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein 2. Endocrin. 1996; 37:4605-4610.
  81. Rosen V, and Wozney JM. . Bone Morphogenetic Proteins and the Adult Skeleton. Skeletal Growth Factors E. Canalis ed. 1996; 229-310.
  82. Inada M, Katagiri T, Akiyama S, Namiki M, Komaki M, Yamaguchi A, Kamoi K, Rosen V, and Suda T. Bone Morphogenetic Protein 12 and 13 inhibit terminal differentiation of myoblasts but do not induce their differentiation into osteoblasts. Biochim Biophy Res Commun. 1996; 222:317-322.
  83. Jaatinen R, Rosen V, Tuuri T, and Rivitos O. Identification of ovarian granulosa cells as a novel site of expression for bone morphogenetic protein-3 (BMP-3/Osteogenin) and regulation of BMP-3 messenger ribonucleic acids by chorionic gonadotropin in cultured human granulosaluteal cells. J Clin Endocrin Metab. 1996; 81:3877-3882.
  84. Rosen V, Cox K, and Hattersley G. . Bone Morphogenetic Proteins. Principles of Bone Biology, Bilezikian et al, eds. 1996; 661-671.
  85. Song JJ, Celeste AJ, Kong FM, Jirtle RL, Rosen V, Thies RS. Bone morphogenetic protein-9 binds to liver cells and stimulates proliferation. Endocrinology. 1995 Oct; 136(10):4293-7. PMID: 7664647.
    View in: PubMed
  86. Gimble JM, Morgan C, Kelly K, Wu X, Dandapani V, Wang CS, Rosen V. Bone morphogenetic proteins inhibit adipocyte differentiation by bone marrow stromal cells. J Cell Biochem. 1995 Jul; 58(3):393-402. PMID: 7593260.
    View in: PubMed
  87. Bostrom MP, Lane JM, Berberian WS, Missri AA, Tomin E, Weiland A, Doty SB, Glaser D, Rosen VM. Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing. J Orthop Res. 1995 May; 13(3):357-67. PMID: 7602397.
    View in: PubMed
  88. Rosen V. . Possible roles for growth factors in bone remodeling. Bone Formation and Repair. JM Lane, CT Brighton, and GE Frielander, eds. 1995; 279-289.
  89. Centrella M, Casinghino S, Kim J, Pham T, Rosen V, Wozney J, and McCarthy TL. Independant changes in type I and type II receptors for transforming growth factor B induced by bone morphogenetic protein 2 parallel expression of the osteoblast phentotype. Mollecular and Cellular Biology. 1995; 15:3273-3281.
  90. Centrella M, Rosen V, Horowitz MC, Wozney JM, and McCarthy TL. Transforming Growth Factor-B Gene Family Members, Their Receptors, and Bone Cell Function. Endocrine Reviews. 1995; 4:211-226.
  91. Rosen V, Thies RS. The Cellular and Molecular Basis of Bone Formation and Repair. 1995.
  92. Yamaji N, Celeste AJ, Thies RS, Song JJ, Bernier SM, Goltzman D, Lyons KM, Nove J, Rosen V, Wozney JM. A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4. Biochem Biophys Res Commun. 1994 Dec 30; 205(3):1944-51. PMID: 7811286.
    View in: PubMed
  93. Wozney JM, Wang E, Rosen V, inventors;. Methods for Producing BMP-7 Proteins. 1994.
  94. Rosen V, Nove J, Song JJ, Teis RS, Cox K, and Wozney JM. Responsiveness of clonal limb bud cell lines to BMP-2 reveals a sequential relationship between cartilage and bone cell phenotypes. J Bone Mineral Res. 1994; 9:1759-1768.
  95. Katagiri T, Yamagucki A, Komaki M, Abe E, Takahashi N, Ikeda T, Rosen V, Wozney JM, Fujisawa-Sehara A, and Suda T. Bone Morphogenetic Protein-2 converts the differntiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biology. 1994; 127:1755-1766.
  96. Yoshikawa H, Rettig WJ, Takoaka K, Alderman EA, Rup B, Rosen V, Healey Jm, Huvos AG, and Gerin-Chesa P. Immunohistochemical detection of BMPs in bone and soft tissue sarcomas. Cancer. 1994; 74:842-847.
  97. Yoshikawa H, Rettig WJ, Takaoka K, Alderman E, Rup B, Rosen V, Wozney JM, Lane JM, Huvos AG, Garin-Chesa P. Expression of bone morphogenetic proteins in human osteosarcoma. Immunohistochemical detection with monoclonal antibody. Cancer. 1994 Jan 1; 73(1):85-91. PMID: 7506120.
    View in: PubMed
  98. Rosen V, and Thies RS. . Skeletal formation and bone morphogenetic proteins. Growth Factors in Perinatal Development. RC Tsang, JA Lemons, and WF Balistreri, eds. 1993; 39-58.
  99. Wozney JM, and Rosen V. Bone Morphogenetic Proteins. Handbook of Experimental Pharmacology. Physiology and Pharmacology of Bone,GR Mundy and TJ Martin eds. 1993; 107:725-748.
  100. Wozney JM, Wang E, Rosen V, Celeste AJ, inventors;. DNA Sequences Encoding BMP-6 Proteins. 1993.
  101. Rosen V, and Thies RS. . Skeletal formation and bone morphogenetic proteins. Growth Factors in Perinatal Development, RC Tsang, JA Lemons, and WF Balistreri, eds. 1993; 39-58.
  102. Rosen V, Capparella J, McQuaid D, Cox K, Thies RS, Song J, Wozney J. Development of immortalized cells derived from 13DPC mouse limb buds as a system to study the effects of recombinant human bone morphogenetic protein 2 on limb bud cell differentiation. Limb Development and Regeneration, J Fallon ed. 1993; 305-315.
  103. Wozney JM, Capparella J, and Rosen V. . The bone morphogenetic proteins in cartilage and bone development. Molecular Basis of Morphogenesis. M. Bernfeld, ed. 1993; 279-289.
  104. Thies RS, Bauduy M, Ashton BA, Kurtzberg L, Wozney JM, Rosen V. Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells. Endocrinology. 1992 Mar; 130(3):1318-24. PMID: 1311236.
    View in: PubMed
  105. Rosen V, Thies RS. The BMP proteins in bone formation and repair. Trends Genet. 1992 Mar; 8(3):97-102. PMID: 1579995.
    View in: PubMed
  106. Wozney JM, Rosen V, Wang E, inventors;. DNA sequences Encoding 5 Proteins (BMP-5). 1992.
  107. Wang E, Wozney JM, Rosen V, inventors;. DNA Sequences Encoding BMP-1 Products. 1992.
  108. Wang E, Wozney JM,Rosen V, inventors; . DNA Sequences Encoding BMP-3. 1992.
  109. Rogers MB, Rosen V, Wozney JM, and Gudas LG. BMP-2 and BMP-4 are involved in the retinoic acid induced differentiation of embryonal carcinoma cells. Molec Biol of the Cell. 1992; 3:189-196.
  110. Yasko AW, Lane JM, Fellinger EJ, Rosen V, Wozney JM, and Wang EA. The healing segmental done defects, induced by rhBMP-2. A radiographic, histological and biomechanical study in rats. J Bone Joint Surg. 1992; 74(A):659-670.
  111. Rosen V, Wang E, Wozney JM, inventors;. DNA Sequences Encoding BMP-7 Proteins. 1992.
  112. Yamaguchi A, Katagiri T, Ikeda T, Wozney JM, Rosen V, Wang EA, Kahn AJ, Suda T, Yoshiki S. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J Cell Biol. 1991 May; 113(3):681-7. PMID: 1849907; PMCID: PMC2288971.
  113. Wang E, Wozney JM, Rosen V, inventors;. DNA Sequences Encoding Osteoinductive Products (BMP-2). 1991.
  114. Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang EA, and Wozney JM. Identification of TGF-B familty members present in bone inductive protein purified from bovine bone. PNAS USA. 1990; 87:9843-9847.
  115. Katagari T, Yamaguchi A, Ikeda T, Yoshiki S, Wozney JM, Rosen V, Wang EA, Tanaka H, Omura s, and Suda T. The non-osteogenic mouse pluripotent cell line C3H10T1/2 is induced to differentiate into osteoblastic cells by rhBMP-2. Biochim Biophys Res Commun. 1990; 172:295-299.
  116. Wozney JM, Rosen V, Byrne M, Celeste AJ, Moutsatsos I, Wang EA. Growth factors influencing bone development. J Cell Sci Suppl. 1990; 13:149-56. PMID: 2084114.
    View in: PubMed
  117. Wang Ea, Rosen V, D'Alessandro JS, Bauduy M, Cordes P, Luxemburg DP, McQuaid D, Moutsatsos IM, Nove J, and Wozney JM. Recombinant human BMP induces bone formation. PNAS. 1990; 87:2220-2224.
  118. Wang E, Rosen V,inventors;. Osteoinductive Factors. 1989.
  119. Rosen V, Wozney JM, Wang EA, Cordes P, Celeste A, McQuaid D, Kurtzberg L. Purification and molecular cloning of a novel group of BMPs and localization of BMP mRNA in developing bone. Connect Tissue Res. 1989; 20(1-4):313-9. PMID: 2612162.
    View in: PubMed
  120. Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA. Novel regulators of bone formation: molecular clones and activities. Science. 1988 Dec 16; 242(4885):1528-34. PMID: 3201241.
    View in: PubMed
  121. Celeste AJ, Rosen V, Buecker JL, Kriz R, Wang EA, and Wozney JM. Isolation of the human gene for bone gla protein utilizing rat and mouse cDNA clones. EMBO. 1986; J(5):1885-1890.
  122. Strum SB, Weiss A, McDermed JE, Rosen VJ. Intrathoracic Hodgkin's disease. A case presentation with multiple pulmonary nodules in the absence of mediastinal or hilar node disease. Cancer. 1985 Oct 15; 56(8):1953-6. PMID: 2411383.
    View in: PubMed
  123. Dunnick JK, Davis WE, Jorgenson TA, Rosen VJ, McConnell EE. Subchronic toxicity in rats administered oral 8-methoxypsoralen. Natl Cancer Inst Monogr. 1984 Dec; 66:91-5. PMID: 6531045.
    View in: PubMed
  124. Castanera TJ, Jones DC, Kimeldorf DJ, Rosen VJ. The influence of whole-body exposure to x-rays or neutrons on the life span distribution of tumors among male rats. Cancer Res. 1968 Feb; 28(2):170-82. PMID: 4295954.
    View in: PubMed
  125. Rosen VJ, Christiansen TW, Hughes RK. Metastatic thymoma presenting as a solitary pulmonary nodule. Cancer. 1966 Apr; 19(4):527-32. PMID: 5935050.
    View in: PubMed
  126. DAVIS WE, COLE LJ, FOLEY WA, ROSEN VJ. LEUKEMIA INCIDENCE AND LONGEVITY IN RADIATION-INDUCED HOMOLOGOUS MOUSE CHIMERAS. Radiat Res. 1963 Sep; 20:43-52. PMID: 14061480.
    View in: PubMed
  127. COLE LJ, ROSEN VJ. Latent radiation-inhibition and recovery of mitotic activity in mouse kidney. Exp Cell Res. 1961 Mar; 23:416-8. PMID: 13694557.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For demographic and contact information changes only, HMS/HSDM faculty should contact Human Resources at human_resourceshms.harvard.edu.
Rosen's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
_
Co-Authors Expand Description
_
Similar People Expand Description
_
Same Department Expand Description
Physical Neighbors Expand Description
_