Harvard Catalyst Profiles

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Nancy U. Lin, M.D.

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Research
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  1. R21CA159270 (MERIC-BERNSTAM, FUNDA) Sep 1, 2011 - Aug 31, 2014
    NIH/NCI
    Akt Inhibitor MK-2206 for Breast Cancers with a PIK3CA Mutation and/or PTEN loss
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Fritz BA, King CR, Ben Abdallah A, Lin N, Mickle AM, Budelier TP, Oberhaus J, Park D, Maybrier HR, Wildes TS, Avidan MS, Apakama G, Aranake-Chrisinger A, Bolzenius J, Burton J, Cui V, Emmert DA, Goswami S, Graetz TJ, Gupta S, Jordan K, Kronzer A, McKinnon SL, Muench MR, Murphy MR, Palanca BJ, Patel A, Spencer JW, Stevens TW, Strutz P, Tedeschi CM, Torres BA, Trammel ER, Upadhyayula RT, Winter AC, Jacobsohn E, Fong T, Gallagher J, Inouye SK, Schmitt EM, Somerville E, Stark S, Lenze EJ, Melby SJ, Tappenden J. Preoperative Cognitive Abnormality, Intraoperative Electroencephalogram Suppression, and Postoperative Delirium: A Mediation Analysis. Anesthesiology. 2020 Jun; 132(6):1458-1468. PMID: 32032096.
    Citations:    
  2. Lin NU, Borges V, Anders C, Murthy RK, Paplomata E, Hamilton E, Hurvitz S, Loi S, Okines A, Abramson V, Bedard PL, Oliveira M, Mueller V, Zelnak A, DiGiovanna MP, Bachelot T, Chien AJ, O'Regan R, Wardley A, Conlin A, Cameron D, Carey L, Curigliano G, Gelmon K, Loibl S, Mayor J, McGoldrick S, An X, Winer EP. Intracranial Efficacy and Survival With Tucatinib Plus Trastuzumab and Capecitabine for Previously Treated HER2-Positive Breast Cancer With Brain Metastases in the HER2CLIMB Trial. J Clin Oncol. 2020 May 29; JCO2000775. PMID: 32468955.
    Citations:    
  3. Freedman RA, Sedrak MS, Bellon JR, Block CC, Lin NU, King TA, Minami C, VanderWalde N, Jolly TA, Muss HB, Winer EP. Weathering the Storm: Managing Older Adults with Breast Cancer Amid COVID-19 and Beyond. J Natl Cancer Inst. 2020 May 25. PMID: 32449757.
    Citations:    
  4. Metzger O, Leone JP, Li T, Tan-Wasielewski Z, Trippa L, Barry WT, Younger J, Lawler E, Walker L, Freedman RA, Tolaney SM, Krop I, Winer EP, Lin NU. Phase I dose-escalation trial of tucatinib in combination with trastuzumab in patients with HER2-positive breast cancer brain metastases. Ann Oncol. 2020 May 24. PMID: 32461105.
    Citations:    
  5. Wander SA, Cohen O, Gong X, Johnson GN, Buendia-Buendia JE, Lloyd MR, Kim D, Luo F, Mao P, Helvie K, Kowalski KJ, Nayar U, Waks AG, Parsons SH, Martinez R, Litchfield LM, Ye XS, Yu C, Jansen VM, Stille JR, Smith PS, Oakley GJ, Chu QS, Batist G, Hughes ME, Kremer JD, Garraway LA, Winer EP, Tolaney SM, Lin NU, Buchanan SG, Wagle N. The genomic landscape of intrinsic and acquired resistance to cyclin-dependent kinase 4/6 inhibitors in patients with hormone receptor positive metastatic breast cancer. Cancer Discov. 2020 May 13. PMID: 32404308.
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  6. Vaz-Luis I, Barroso-Sousa R, Di Meglio A, Hu J, Rees R, Sinclair N, Milisits L, Leone JP, Constantine M, Faggen M, Briccetti F, Block C, O'Neil K, Partridge A, Burstein H, Waks AG, Trippa L, Tolaney SM, Hassett M, Winer EP, Lin NU. Avoiding Peg-Filgrastim Prophylaxis During the Paclitaxel Portion of the Dose-Dense Doxorubicin-Cyclophosphamide and Paclitaxel Regimen: A Prospective Study. J Clin Oncol. 2020 Apr 24; JCO1902484. PMID: 32330102.
    Citations:    
  7. Zhong J, Wang B, Chen Y, Li H, Lin N, Xu X, Lu H. Relationship between body mass index and the risk of periprosthetic joint infection after primary total hip arthroplasty and total knee arthroplasty. Ann Transl Med. 2020 Apr; 8(7):464. PMID: 32395508.
    Citations:    
  8. Li BT, Michelini F, Misale S, Cocco E, Baldino L, Cai Y, Shifman S, Tu HY, Myers ML, Xu C, Mattar M, Khodos I, Little M, Qeriqi B, Weitsman G, Wilhem CJ, Lalani AS, Diala I, Freedman RA, Lin NU, Solit DB, Berger MF, Barber PR, Ng T, Offin M, Isbell JM, Jones DR, Yu HA, Thyparambil S, Liao WL, Bhalkikar A, Cecchi F, Hyman DM, Lewis JS, Buonocore DJ, Ho AL, Makker V, Reis-Filho JS, Razavi P, Arcila ME, Kris MG, Poirier JT, Shen R, Tsurutani J, Ulaner GA, de Stanchina E, Rosen N, Rudin CM, Scaltriti M. HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers. Cancer Discov. 2020 May; 10(5):674-687. PMID: 32213539.
    Citations:    
  9. Parsons HA, Rhoades J, Reed SC, Gydush G, Ram P, Exman P, Xiong K, Lo CC, Li T, Fleharty M, Kirkner GJ, Rotem D, Cohen O, Yu F, Fitarelli-Kiehl M, Leong KW, Hughes ME, Rosenberg SM, Collins LC, Miller KD, Blumenstiel B, Trippa L, Cibulskis C, Neuberg DS, DeFelice M, Freeman SS, Lennon NJ, Wagle N, Ha G, Stover DG, Choudhury AD, Getz G, Winer EP, Meyerson M, Lin NU, Krop I, Love JC, Makrigiorgos GM, Partridge AH, Mayer EL, Golub TR, Adalsteinsson VA. Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer. Clin Cancer Res. 2020 Jun 01; 26(11):2556-2564. PMID: 32170028.
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  10. Castle JR, Lin N, Liu J, Storniolo AMV, Shendre A, Hou L, Horvath S, Liu Y, Wang C, He C. Estimating breast tissue-specific DNA methylation age using next-generation sequencing data. Clin Epigenetics. 2020 Mar 12; 12(1):45. PMID: 32164769.
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  11. Waks AG, Cohen O, Kochupurakkal B, Kim D, Dunn CE, Buendia Buendia J, Wander S, Helvie K, Lloyd MR, Marini L, Hughes ME, Freeman SS, Ivy SP, Geradts J, Isakoff S, LoRusso P, Adalsteinsson VA, Tolaney SM, Matulonis U, Krop IE, D'Andrea AD, Winer EP, Lin NU, Shapiro GI, Wagle N. Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer. Ann Oncol. 2020 May; 31(5):590-598. PMID: 32245699.
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  12. Sperduto PW, Mesko S, Li J, Cagney D, Aizer A, Lin NU, Nesbit E, Kruser TJ, Chan J, Braunstein S, Lee J, Kirkpatrick JP, Breen W, Brown PD, Shi D, Shih HA, Soliman H, Sahgal A, Shanley R, Sperduto W, Lou E, Everett A, Boggs DH, Masucci L, Roberge D, Remick J, Plichta K, Buatti JM, Jain S, Gaspar LE, Wu CC, Wang TJC, Bryant J, Chuong M, Yu J, Chiang V, Nakano T, Aoyama H, Mehta MP. Beyond an Updated Graded Prognostic Assessment (Breast GPA): A Prognostic Index and Trends in Treatment and Survival in Breast Cancer Brain Metastases From 1985 to Today. Int J Radiat Oncol Biol Phys. 2020 Jun 01; 107(2):334-343. PMID: 32084525.
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  13. Vaklavas C, Roberts BS, Varley KE, Lin NU, Liu MC, Rugo HS, Puhalla S, Nanda R, Storniolo AM, Carey LA, Saleh MN, Li Y, Delossantos JF, Grizzle WE, LoBuglio AF, Myers RM, Forero-Torres A. TBCRC 002: a phase II, randomized, open-label trial of preoperative letrozole with or without bevacizumab in postmenopausal women with newly diagnosed stage 2/3 hormone receptor-positive and HER2-negative breast cancer. Breast Cancer Res. 2020 02 18; 22(1):22. PMID: 32070401.
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  14. Kaufmann TJ, Smits M, Boxerman J, Huang R, Barboriak DP, Weller M, Chung C, Tsien C, Brown PD, Shankar L, Galanis E, Gerstner E, van den Bent MJ, Burns TC, Parney IF, Dunn G, Brastianos PK, Lin NU, Wen PY, Ellingson BM. Consensus recommendations for a standardized brain tumor imaging protocol for clinical trials in brain metastases (BTIP-BM). Neuro Oncol. 2020 Feb 12. PMID: 32048719.
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  15. Sperduto PW, Mesko S, Li J, Cagney D, Aizer A, Lin NU, Nesbit E, Kruser TJ, Chan J, Braunstein S, Lee J, Kirkpatrick JP, Breen W, Brown PD, Shi D, Shih HA, Soliman H, Sahgal A, Shanley R, Sperduto W, Lou E, Everett A, Boggs DH, Masucci L, Roberge D, Remick J, Plichta K, Buatti JM, Jain S, Gaspar LE, Wu CC, Wang TJC, Bryant J, Chuong M, Yu J, Chiang V, Nakano T, Aoyama H, Mehta MP. Estrogen, Progesterone and HER2 Receptor Discordance Between Primary Tumor and Brain Metastases in Breast Cancer and Its Effect on Treatment and Survival. Neuro Oncol. 2020 Feb 08. PMID: 32034917.
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  16. Barroso-Sousa R, Keenan TE, Pernas S, Exman P, Jain E, Garrido-Castro AC, Hughes M, Bychkovsky B, Umeton R, Files JL, Lindeman NI, MacConaill LE, Hodi FS, Krop IE, Dillon D, Winer EP, Wagle N, Lin NU, Mittendorf EA, Van Allen EM, Tolaney SM. Tumor Mutational Burden and PTEN Alterations as Molecular Correlates of Response to PD-1/L1 Blockade in Metastatic Triple-Negative Breast Cancer. Clin Cancer Res. 2020 Jun 01; 26(11):2565-2572. PMID: 32019858.
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  17. Hulsbergen AFC, Claes A, Kavouridis VK, Ansaripour A, Nogarede C, Hughes ME, Smith TR, Brastianos PK, Verhoeff JJC, Lin NU, Broekman MLD. Subtype switching in breast cancer brain metastases: a multicenter analysis. Neuro Oncol. 2020 Jan 23. PMID: 31970416.
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  18. Hulsbergen AFC, Cho LD, Mammi M, Lamba N, Smith TR, Brastianos PK, Broekman MLD, Lin NU. Systemic therapy following craniotomy in patients with a solitary breast cancer brain metastasis. Breast Cancer Res Treat. 2020 Feb; 180(1):147-155. PMID: 31953697.
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  19. Barroso-Sousa R, Jain E, Cohen O, Kim D, Buendia-Buendia J, Winer E, Lin N, Tolaney SM, Wagle N. Prevalence and mutational determinants of high tumor mutation burden in breast cancer. Ann Oncol. 2020 Mar; 31(3):387-394. PMID: 32067680.
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  20. Murthy RK, Loi S, Okines A, Paplomata E, Hamilton E, Hurvitz SA, Lin NU, Borges V, Abramson V, Anders C, Bedard PL, Oliveira M, Jakobsen E, Bachelot T, Shachar SS, Müller V, Braga S, Duhoux FP, Greil R, Cameron D, Carey LA, Curigliano G, Gelmon K, Hortobagyi G, Krop I, Loibl S, Pegram M, Slamon D, Palanca-Wessels MC, Walker L, Feng W, Winer EP. Tucatinib, Trastuzumab, and Capecitabine for HER2-Positive Metastatic Breast Cancer. N Engl J Med. 2020 02 13; 382(7):597-609. PMID: 31825569.
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  21. Olson EM, Lin NU, DiPiro PJ, Najita JS, Krop IE, Winer EP, Burstein HJ. Responses to subsequent anti-HER2 therapy after treatment with trastuzumab-DM1 in women with HER2-positive metastatic breast cancer. Ann Oncol. 2012 Jan; 23(1):93-97. PMID: 32018392.
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  22. Vaz-Luis I, Winer EP, Lin NU. Human epidermal growth factor receptor-2-positive breast cancer: does estrogen receptor status define two distinct subtypes? Ann Oncol. 2013 Feb; 24(2):283-291. PMID: 32018397.
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  23. Seah DS, Scott SM, Najita J, Openshaw T, Krag K, Frank E, Sohl J, Stadler ZK, Garrett M, Silverman SG, Peppercorn J, Winer EP, Come SE, Lin NU. Attitudes of patients with metastatic breast cancer toward research biopsies. Ann Oncol. 2013 Jul; 24(7):1853-1859. PMID: 32018624.
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  24. Exman P, Mallery RM, Lin NU, Parsons HA. Response to Olaparib in a Patient with Germline BRCA2 Mutation and Breast Cancer Leptomeningeal Carcinomatosis. NPJ Breast Cancer. 2019; 5:46. PMID: 31815182.
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  25. Liu Y, Li Z, Ge Q, Lin N, Xiong M. Deep Feature Selection and Causal Analysis of Alzheimer's Disease. Front Neurosci. 2019; 13:1198. PMID: 31802999.
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  26. Lu W, Giobbie-Hurder A, Freedman RA, Shin IH, Lin NU, Partridge AH, Rosenthal DS, Ligibel JA. Acupuncture for Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer Survivors: A Randomized Controlled Pilot Trial. Oncologist. 2019 Oct 14. PMID: 31611333.
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  27. Lu W, Giobbie-Hurder A, Freedman RA, Shin IH, Lin NU, Partridge AH, Rosenthal DS, Ligibel JA. Acupuncture for Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer Survivors: A Randomized Controlled Pilot Trial. Oncologist. 2020 Apr; 25(4):310-318. PMID: 32297442.
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  28. Song Y, Barry WT, Seah DS, Tung NM, Garber JE, Lin NU. Patterns of recurrence and metastasis in BRCA1/BRCA2-associated breast cancers. Cancer. 2020 Jan 15; 126(2):271-280. PMID: 31581314.
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  29. Yin L, Wan YD, Pan XT, Zhou CY, Lin N, Ma CT, Yao J, Su Z, Wan C, Yu YW, Zhu RX. Association Between Gut Bacterial Diversity and Mortality in Septic Shock Patients: A Cohort Study. Med Sci Monit. 2019 Oct 01; 25:7376-7382. PMID: 31574078.
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  30. Leone JP, Duda DG, Hu J, Barry WT, Trippa L, Gerstner ER, Jain RK, Tan S, Lawler E, Winer EP, Lin NU, Tolaney SM. A phase II study of cabozantinib alone or in combination with trastuzumab in breast cancer patients with brain metastases. Breast Cancer Res Treat. 2020 Jan; 179(1):113-123. PMID: 31541381.
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  31. Deng Y, Liu H, Lin N, Ma L, Fu W. Influence of dry weight reduction on anemia in patients undergoing hemodialysis. J Int Med Res. 2019 Nov; 47(11):5536-5547. PMID: 31530055.
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  32. Freedman RA, Gelman RS, Agar NYR, Santagata S, Randall EC, Gimenez-Cassina Lopez B, Connolly RM, Dunn IF, Van Poznak CH, Anders CK, Melisko ME, Silvestri K, Cotter CM, Componeschi KP, Marte JM, Moy B, Blackwell KL, Puhalla SL, Ibrahim N, Moynihan TJ, Nangia J, Tung N, Burns R, Rimawi MF, Krop IE, Wolff AC, Winer EP, Lin NU. Pre- and Postoperative Neratinib for HER2-Positive Breast Cancer Brain Metastases: Translational Breast Cancer Research Consortium 022. Clin Breast Cancer. 2020 Apr; 20(2):145-151.e2. PMID: 31558424.
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  33. Singh J, Asad S, Zhang Y, Nock W, Adams E, Damicis A, Ramaswamy B, Williams N, Parsons HA, Adalsteinsson VA, Winer EP, Lin NU, Partridge AH, Overmoyer B, Stover DG. Aggressive Subsets of Metastatic Triple Negative Breast Cancer. Clin Breast Cancer. 2020 Feb; 20(1):e20-e26. PMID: 31631016.
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  34. Peng H, Zhang Y, Zhou Z, Guo Y, Huang X, Westover KD, Zhang Z, Chen B, Hua Y, Li S, Xu R, Lin N, Peng B, Shen S. Intergrated analysis of ELMO1, serves as a link between tumour mutation burden and epithelial-mesenchymal transition in hepatocellular carcinoma. EBioMedicine. 2019 Aug; 46:105-118. PMID: 31324602.
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  35. Xing Y, Lin NU, Maurer MA, Chen H, Mahvash A, Sahin A, Akcakanat A, Li Y, Abramson V, Litton J, Chavez-MacGregor M, Valero V, Piha-Paul SA, Hong D, Do KA, Tarco E, Riall D, Eterovic AK, Wulf GM, Cantley LC, Mills GB, Doyle LA, Winer E, Hortobagyi GN, Gonzalez-Angulo AM, Meric-Bernstam F. Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation. Breast Cancer Res. 2019 07 05; 21(1):78. PMID: 31277699.
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  36. Lin N, Han R, Hui X, Zhang K, Gelb AW. Midazolam Sedation Induces Upper Limb Coordination Deficits That Are Reversed by Flumazenil in Patients with Eloquent Area Gliomas. Anesthesiology. 2019 07; 131(1):36-45. PMID: 31094751.
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  37. Jaeger AM, Stopfer L, Lee S, Gaglia G, Sandel D, Santagata S, Lin NU, Trepel JB, White F, Jacks T, Lindquist S, Whitesell L. Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation. Clin Cancer Res. 2019 11 01; 25(21):6392-6405. PMID: 31213460.
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  38. Yue CY, Lin N, Gao L, Jin YX, Liu ZY, Cao YY, Han SS, Lian XK, Hu B, Lei XW. Organic cation directed one-dimensional cuprous halide compounds: syntheses, crystal structures and photoluminescence properties. Dalton Trans. 2019 Jul 21; 48(27):10151-10159. PMID: 31185070.
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  39. Yue CY, Yue YD, Sun HX, Li DY, Lin N, Wang XM, Jin YX, Dong YH, Jing ZH, Lei XW. Transition metal complex dye-sensitized 3D iodoplumbates: syntheses, structures and photoelectric properties. Chem Commun (Camb). 2019 Jun 11; 55(48):6874-6877. PMID: 31125034.
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  40. Zhong J, Cao K, Wang B, Zhou X, Lin N, Lu H. The Perioperative Efficacy and Safety of Tranexamic Acid in Adolescent Idiopathic Scoliosis. World Neurosurg. 2019 Sep; 129:e726-e732. PMID: 31176837.
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  41. Lee EQ, Chukwueke UN, Hervey-Jumper SL, de Groot JF, Leone JP, Armstrong TS, Chang SM, Arons D, Oliver K, Verble K, Musella A, Willmarth N, Alexander BM, Bates A, Doherty L, Galanis E, Gaffey S, Halkin T, Friday BE, Fouladi M, Lin NU, Macdonald D, Mehta MP, Penas-Prado M, Vogelbaum MA, Sahebjam S, Sandak D, van den Bent M, Weller M, Reardon DA, Wen PY. Barriers to Accrual and Enrollment in Brain Tumor Trials. Neuro Oncol. 2019 Jun 07. PMID: 31175826.
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  42. Loughlin AM, Lin N, Abler V, Carroll B. Tardive dyskinesia among patients using antipsychotic medications in customary clinical care in the United States. PLoS One. 2019; 14(6):e0216044. PMID: 31163035.
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  43. Leone JP, Lin NU. Correction to: Systemic Therapy of Central Nervous System Metastases of Breast Cancer. Curr Oncol Rep. 2019 May 17; 21(7):59. PMID: 31098730.
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  44. Ding S, Lin N, Sheng X, Zhao Y, Su Y, Xu L, Tong R, Yan Y, Fu Y, He J, Gao Y, Yuan A, Ye L, Reiter RJ, Pu J. Melatonin stabilizes rupture-prone vulnerable plaques via regulating macrophage polarization in a nuclear circadian receptor RORa-dependent manner. J Pineal Res. 2019 Sep; 67(2):e12581. PMID: 31009101.
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  45. Boire A, Brandsma D, Brastianos PK, Le Rhun E, Ahluwalia M, Junck L, Glantz M, Groves MD, Lee EQ, Lin N, Raizer J, Rudà R, Weller M, Van den Bent MJ, Vogelbaum MA, Chang S, Wen PY, Soffietti R. Liquid biopsy in central nervous system metastases: a RANO review and proposals for clinical applications. Neuro Oncol. 2019 05 06; 21(5):571-584. PMID: 30668804.
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  46. Hulsbergen AFC, Lamba N, Claes A, Kavouridis VK, Lin NU, Smith TR, Verhoeff JJC, Broekman MLD. Prognostic Value of Brain Metastasis-Free Interval in Patients with Breast Cancer Brain Metastases. World Neurosurg. 2019 Aug; 128:e157-e164. PMID: 31035019.
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  47. Cagney DN, Lamba N, Montoya S, Li P, Besse L, Martin AM, Brigell RH, Catalano PJ, Brown PD, Leone JP, Tanguturi SK, Haas-Kogan DA, Alexander BM, Lin NU, Aizer AA. Breast cancer subtype and intracranial recurrence patterns after brain-directed radiation for brain metastases. Breast Cancer Res Treat. 2019 Jul; 176(1):171-179. PMID: 30982195.
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  48. Leone JP, Lin NU. Systemic Therapy of Central Nervous System Metastases of Breast Cancer. Curr Oncol Rep. 2019 04 08; 21(6):49. PMID: 30957209.
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  49. Wang Y, Yu B, Zhong F, Guo Q, Li K, Hou Y, Lin N. MRI-based texture analysis of the primary tumor for pre-treatment prediction of bone metastases in prostate cancer. Magn Reson Imaging. 2019 07; 60:76-84. PMID: