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Tobias F.I. Schatton, Ph.D., Pharm.D.

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Research
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  1. R01CA247957 (SCHATTON, TOBIAS) Dec 1, 2020 - Nov 30, 2025
    NIH
    Functional analysis of a novel integrin-dependent metastasis pathway in melanoma
    Role: Principal Investigator
  2. R01CA190838 (SCHATTON, TOBIAS) Sep 13, 2017 - Jul 31, 2022
    NIH
    Role of melanoma-PD-1 in cancer progression
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Schatton T, Itoh Y, Martins C, Rasbach E, Singh P, Silva M, Mucciarone K, Heppt MV, Geddes-Sweeney J, Stewart K, Brandenburg A, Liang J, Dimitroff CJ, Mihm MC, Landsberg J, Schlapbach C, Lian CG, Murphy GF, Kupper TS, Ramsey MR, Barthel SR. Inhibition of Melanoma Cell-Intrinsic Tim-3 Stimulates MAPK-Dependent Tumorigenesis. Cancer Res. 2022 10 17; 82(20):3774-3784. PMID: 35980306; PMCID: PMC9598011.
    Citations:    Fields:    Translation:HumansAnimals
  2. Martins C, Silva M, Rasbach E, Singh P, Itoh Y, Williams JB, Statham E, Meurer A, Martinez DV, Brandenburg A, Heppt MV, Barthel SR, Schatton T. Distinct antibody clones detect PD-1 checkpoint expression and block PD-L1 interactions on live murine melanoma cells. Sci Rep. 2022 07 21; 12(1):12491. PMID: 35864188; PMCID: PMC9304406.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  3. Petzold A, Steeb T, Wessely A, Schatton T, Berking C, Heppt MV. Comparative efficacy analysis identifies immune checkpoint blockade as a new survival benchmark in advanced cutaneous squamous cell carcinoma. Eur J Cancer. 2022 07; 170:42-53. PMID: 35594611.
    Citations: 1     Fields:    Translation:Humans
  4. Dousset L, Martins C, Jacquemin C, Amico S, Schatton T, Boniface K, Seneschal J. Complete response in a patient with advanced melanoma following anti-PD-1 therapy is associated with a high frequency of melanoma-infiltrating CXCR3+ resident memory CD8+ T cells and multiple chemokine pathways. Br J Dermatol. 2021 09; 185(3):663-666. PMID: 33894001.
    Citations:    Fields:    Translation:HumansCells
  5. Ordikhani F, Uehara M, Kasinath V, Dai L, Eskandari SK, Bahmani B, Yonar M, Azzi JR, Haik Y, Sage PT, Murphy GF, Annabi N, Schatton T, Guleria I, Abdi R. Targeting antigen-presenting cells by anti-PD-1 nanoparticles augments antitumor immunity. JCI Insight. 2018 10 18; 3(20). PMID: 30333312.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  6. Kollmann D, Ignatova D, Jedamzik J, Chang YT, Jomrich G, Baierl A, Kazakov D, Michal M, French LE, Hoetzenecker W, Schatton T, Asari R, Preusser M, Gnant M, Guenova E, Schoppmann SF. PD-L1 expression is an independent predictor of favorable outcome in patients with localized esophageal adenocarcinoma. Oncoimmunology. 2018; 7(6):e1435226. PMID: 29872575.
    Citations: 23     Fields:    
  7. Kollmann D, Ignatova D, Jedamzik J, Chang YT, Jomrich G, Paireder M, Kristo I, Kazakov D, Michal M, Cozzio A, Hoetzenecker W, Schatton T, Asari R, Preusser M, Guenova E, Schoppmann SF. Expression of Programmed Cell Death Protein 1 by Tumor-Infiltrating Lymphocytes and Tumor Cells is Associated with Advanced Tumor Stage in Patients with Esophageal Adenocarcinoma. Ann Surg Oncol. 2017 Sep; 24(9):2698-2706. PMID: 28429196; PMCID: PMC5539275.
    Citations: 11     Fields:    Translation:HumansCells
  8. Sackstein R, Schatton T, Barthel SR. T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy. Lab Invest. 2017 06; 97(6):669-697. PMID: 28346400; PMCID: PMC5446300.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  9. Barthel SR, Schatton T. Homing in on the Sweet Side of Immune Checkpoint Biology. Immunity. 2016 05 17; 44(5):1083-5. PMID: 27192573.
    Citations: 3     Fields:    Translation:HumansCells
  10. Kleffel S, Lee N, Lezcano C, Wilson BJ, Sobolewski K, Saab KR, Mueller H, Zhan Q, Posch C, Elco CP, DoRosario A, Garcia SS, Thakuria M, Wang YE, Wang LC, Murphy GF, Frank MH, Schatton T. ABCB5-Targeted Chemoresistance Reversal Inhibits Merkel Cell Carcinoma Growth. J Invest Dermatol. 2016 Apr; 136(4):838-846. PMID: 26827764; PMCID: PMC4821468.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  11. Schatton T, Schütte U, Frank MH. Effects of Malignant Melanoma Initiating Cells on T-Cell Activation. Methods Mol Biol. 2016 Jan 20. PMID: 26786883; PMCID: PMC4956572.
    Citations: 1     Fields:    
  12. Lee N, Zakka LR, Mihm MC, Schatton T. Tumour-infiltrating lymphocytes in melanoma prognosis and cancer immunotherapy. Pathology. 2016 Feb; 48(2):177-87. PMID: 27020390.
    Citations: 112     Fields:    Translation:HumansCells
  13. Kleffel S, Posch C, Barthel SR, Mueller H, Schlapbach C, Guenova E, Elco CP, Lee N, Juneja VR, Zhan Q, Lian CG, Thomi R, Hoetzenecker W, Cozzio A, Dummer R, Mihm MC, Flaherty KT, Frank MH, Murphy GF, Sharpe AH, Kupper TS, Schatton T. Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth. Cell. 2015 Sep 10; 162(6):1242-56. PMID: 26359984; PMCID: PMC4700833.
    Citations: 280     Fields:    Translation:HumansAnimalsCells
  14. Schatton T, Yang J, Kleffel S, Uehara M, Barthel SR, Schlapbach C, Zhan Q, Dudeney S, Mueller H, Lee N, de Vries JC, Meier B, Vander Beken S, Kluth MA, Ganss C, Sharpe AH, Waaga-Gasser AM, Sayegh MH, Abdi R, Scharffetter-Kochanek K, Murphy GF, Kupper TS, Frank NY, Frank MH. ABCB5 Identifies Immunoregulatory Dermal Cells. Cell Rep. 2015 Sep 08; 12(10):1564-74. PMID: 26321644.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  15. Posch C, Cholewa BD, Vujic I, Sanlorenzo M, Ma J, Kim ST, Kleffel S, Schatton T, Rappersberger K, Gutteridge R, Ahmad N, Ortiz/Urda S. Combined Inhibition of MEK and Plk1 Has Synergistic Antitumor Activity in NRAS Mutant Melanoma. J Invest Dermatol. 2015 Oct; 135(10):2475-2483. PMID: 26016894; PMCID: PMC4567913.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  16. Yazawa EM, Geddes-Sweeney JE, Cedeno-Laurent F, Walley KC, Barthel SR, Opperman MJ, Liang J, Lin JY, Schatton T, Laga AC, Mihm MC, Qureshi AA, Widlund HR, Murphy GF, Dimitroff CJ. Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential. J Invest Dermatol. 2015 Jul; 135(7):1849-1862. PMID: 25756799; PMCID: PMC4466041.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  17. Lee CW, Zhan Q, Lezcano C, Frank MH, Huang J, Larson AR, Lin JY, Wan MT, Lin PI, Ma J, Kleffel S, Schatton T, Lian CG, Murphy GF. Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest. 2014 Dec; 94(12):1382-95. PMID: 25365206; PMCID: PMC4419570.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  18. Kleffel S, Vergani A, Tezza S, Ben Nasr M, Niewczas MA, Wong S, Bassi R, D'Addio F, Schatton T, Abdi R, Atkinson M, Sayegh MH, Wen L, Wasserfall CH, O'Connor KC, Fiorina P. Interleukin-10+ regulatory B cells arise within antigen-experienced CD40+ B cells to maintain tolerance to islet autoantigens. Diabetes. 2015 Jan; 64(1):158-71. PMID: 25187361; PMCID: PMC4274804.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  19. Lezcano C, Kleffel S, Lee N, Larson AR, Zhan Q, DoRosario A, Wang LC, Schatton T, Murphy GF. Merkel cell carcinoma expresses vasculogenic mimicry: demonstration in patients and experimental manipulation in xenografts. Lab Invest. 2014 Oct; 94(10):1092-102. PMID: 25111691; PMCID: PMC4236190.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  20. Wilson BJ, Saab KR, Ma J, Schatton T, Pütz P, Zhan Q, Murphy GF, Gasser M, Waaga-Gasser AM, Frank NY, Frank MH. ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit. Cancer Res. 2014 Aug 01; 74(15):4196-207. PMID: 24934811.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  21. Schatton T, Scolyer RA, Thompson JF, Mihm MC. Tumor-infiltrating lymphocytes and their significance in melanoma prognosis. Methods Mol Biol. 2014; 1102:287-324. PMID: 24258985.
    Citations: 38     Fields:    Translation:HumansCells
  22. Lee N, Barthel SR, Schatton T. Melanoma stem cells and metastasis: mimicking hematopoietic cell trafficking? Lab Invest. 2014 Jan; 94(1):13-30. PMID: 24126889; PMCID: PMC3941309.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  23. Lin JY, Zhang M, Schatton T, Wilson BJ, Alloo A, Ma J, Qureshi AA, Frank NY, Han J, Frank MH. Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk. Biochem Biophys Res Commun. 2013 Jul 05; 436(3):536-42. PMID: 23770371.
    Citations: 8     Fields:    Translation:HumansCells
  24. Kleffel S, Schatton T. Tumor dormancy and cancer stem cells: two sides of the same coin? Adv Exp Med Biol. 2013; 734:145-79. PMID: 23143979.
    Citations: 69     Fields:    Translation:HumansCells
  25. Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q, Lee CW, Hu D, Lian BQ, Kleffel S, Yang Y, Neiswender J, Khorasani AJ, Fang R, Lezcano C, Duncan LM, Scolyer RA, Thompson JF, Kakavand H, Houvras Y, Zon LI, Mihm MC, Kaiser UB, Schatton T, Woda BA, Murphy GF, Shi YG. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell. 2012 Sep 14; 150(6):1135-46. PMID: 22980977; PMCID: PMC3770275.
    Citations: 365     Fields:    Translation:HumansCells
  26. Cedeno-Laurent F, Opperman MJ, Barthel SR, Hays D, Schatton T, Zhan Q, He X, Matta KL, Supko JG, Frank MH, Murphy GF, Dimitroff CJ. Metabolic inhibition of galectin-1-binding carbohydrates accentuates antitumor immunity. J Invest Dermatol. 2012 Feb; 132(2):410-20. PMID: 22158550.
    Citations: 30     Fields:    Translation:AnimalsCells
  27. Wilson BJ, Schatton T, Zhan Q, Gasser M, Ma J, Saab KR, Schanche R, Waaga-Gasser AM, Gold JS, Huang Q, Murphy GF, Frank MH, Frank NY. ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients. Cancer Res. 2011 Aug 01; 71(15):5307-16. PMID: 21652540.
    Citations: 63     Fields:    Translation:HumansAnimals
  28. Wilson BJ, Schatton T, Frank MH, Frank NY. Colorectal Cancer Stem Cells: Biology and Therapeutic Implications. Curr Colorectal Cancer Rep. 2011 Jun; 7(2):128-135. PMID: 21552371.
    Citations: 23     
  29. Ho J, Pandey P, Schatton T, Sims-Lucas S, Khalid M, Frank MH, Hartwig S, Kreidberg JA. The pro-apoptotic protein Bim is a microRNA target in kidney progenitors. J Am Soc Nephrol. 2011 Jun; 22(6):1053-63. PMID: 21546576.
    Citations: 59     Fields:    Translation:AnimalsCells
  30. Frank NY, Schatton T, Kim S, Zhan Q, Wilson BJ, Ma J, Saab KR, Osherov V, Widlund HR, Gasser M, Waaga-Gasser AM, Kupper TS, Murphy GF, Frank MH. VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res. 2011 Feb 15; 71(4):1474-85. PMID: 21212411.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  31. Ma J, Lin JY, Alloo A, Wilson BJ, Schatton T, Zhan Q, Murphy GF, Waaga-Gasser AM, Gasser M, Stephen Hodi F, Frank NY, Frank MH. Isolation of tumorigenic circulating melanoma cells. Biochem Biophys Res Commun. 2010 Nov 26; 402(4):711-7. PMID: 20977885.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  32. Yamaura K, Watanabe T, Boenisch O, Yeung M, Yang S, Magee CN, Padera R, Datta S, Schatton T, Kamimura Y, Azuma M, Najafian N. In vivo function of immune inhibitory molecule B7-H4 in alloimmune responses. Am J Transplant. 2010 Oct; 10(10):2355-62. PMID: 21143433.
    Citations: 9     Fields:    Translation:AnimalsCells
  33. Schatton T, Frank MH. The in vitro spheroid melanoma cell culture assay: cues on tumor initiation? J Invest Dermatol. 2010 Jul; 130(7):1769-71. PMID: 20548315.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  34. Izawa A, Schatton T, Frank NY, Ueno T, Yamaura K, Pendse SS, Margaryan A, Grimm M, Gasser M, Waaga-Gasser AM, Sayegh MH, Frank MH. A novel in vivo regulatory role of P-glycoprotein in alloimmunity. Biochem Biophys Res Commun. 2010 Apr 09; 394(3):646-52. PMID: 20230790; PMCID: PMC3756468.
    Citations: 5     Fields:    Translation:AnimalsCells
  35. Schatton T, Schütte U, Frank NY, Zhan Q, Hoerning A, Robles SC, Zhou J, Hodi FS, Spagnoli GC, Murphy GF, Frank MH. Modulation of T-cell activation by malignant melanoma initiating cells. Cancer Res. 2010 Jan 15; 70(2):697-708. PMID: 20068175.
    Citations: 145     Fields:    Translation:HumansAnimalsCells
  36. Frank NY, Schatton T, Frank MH. The therapeutic promise of the cancer stem cell concept. J Clin Invest. 2010 Jan; 120(1):41-50. PMID: 20051635; PMCID: PMC2798700.
    Citations: 303     Fields:    Translation:HumansAnimalsCells
  37. Schatton T, Frank NY, Frank MH. Identification and targeting of cancer stem cells. Bioessays. 2009 Oct; 31(10):1038-49. PMID: 19708024.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  38. Schatton T, Frank MH. Antitumor immunity and cancer stem cells. Ann N Y Acad Sci. 2009 Sep; 1176:154-69. PMID: 19796244.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  39. Schatton T, Frank MH. Cancer stem cells and human malignant melanoma. Pigment Cell Melanoma Res. 2008 Feb; 21(1):39-55. PMID: 18353142.
    Citations: 88     Fields:    Translation:HumansCells
  40. Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH. Identification of cells initiating human melanomas. Nature. 2008 Jan 17; 451(7176):345-9. PMID: 18202660.
    Citations: 579     Fields:    Translation:HumansAnimalsCells
  41. Pendse SS, Behjati S, Schatton T, Izawa A, Sayegh MH, Frank MH. P-glycoprotein functions as a differentiation switch in antigen presenting cell maturation. Am J Transplant. 2006 Dec; 6(12):2884-93. PMID: 17083370.
    Citations: 16     Fields:    Translation:HumansCells
  42. Frank NY, Kho AT, Schatton T, Murphy GF, Molloy MJ, Zhan Q, Ramoni MF, Frank MH, Kohane IS, Gussoni E. Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin. J Cell Biol. 2006 Oct 09; 175(1):99-110. PMID: 17015616; PMCID: PMC2064502.
    Citations: 34     Fields:    Translation:HumansCells
  43. Frank NY, Margaryan A, Huang Y, Schatton T, Waaga-Gasser AM, Gasser M, Sayegh MH, Sadee W, Frank MH. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res. 2005 May 15; 65(10):4320-33. PMID: 15899824.
    Citations: 215     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.