Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Pamela A. Silver, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. T32GM080177 (MITCHISON, TIMOTHY J) Jul 1, 2010 - Jun 30, 2020
    NIH/NIGMS
    Harvard Systems Biology Graduate Program
    Role: Co-Principal Investigator
  2. R01GM057476 (SILVER, PAMELA A.) May 1, 1998 - Apr 30, 2011
    NIH/NIGMS
    Connecting the Genome to the Cytoplasm
    Role: Principal Investigator
  3. R37GM036373 (SILVER, PAMELA A) Jun 1, 1993 - Mar 31, 2013
    NIH/NIGMS
    Transport of Proteins In and Out of the Nucleus
    Role: Principal Investigator
  4. R01GM047385 (SILVER, PAMELA A.) May 1, 1992 - May 31, 1997
    NIH/NIGMS
    EUKARYOTIC DNA J PROTEINS THAT REGULATE HSP70 ACTION
    Role: Principal Investigator
  5. R01GM036373 (SILVER, PAMELA A) Apr 1, 1986 - May 31, 1993
    NIH/NIGMS
    Designing Biological Circuits
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hsu BB, Plant IN, Lyon L, Anastassacos FM, Way JC, Silver PA. In situ reprogramming of gut bacteria by oral delivery. Nat Commun. 2020 10 06; 11(1):5030. PMID: 33024097.
    Citations:    Fields:    
  2. Nangle SN, Ziesack M, Buckley S, Trivedi D, Loh DM, Nocera DG, Silver PA. Valorization of CO2 through lithoautotrophic production of sustainable chemicals in Cupriavidus necator. Metab Eng. 2020 Nov; 62:207-220. PMID: 32961296.
    Citations:    Fields:    
  3. Kuo J, Yuan R, Sánchez C, Paulsson J, Silver PA. Toward a translationally independent RNA-based synthetic oscillator using deactivated CRISPR-Cas. Nucleic Acids Res. 2020 08 20; 48(14):8165-8177. PMID: 32609820.
    Citations:    Fields:    
  4. Qian J, Lu ZX, Mancuso CP, Jhuang HY, Del Carmen Barajas-Ornelas R, Boswell SA, Ramírez-Guadiana FH, Jones V, Sonti A, Sedlack K, Artzi L, Jung G, Arammash M, Pettit ME, Melfi M, Lyon L, Owen SV, Baym M, Khalil AS, Silver PA, Rudner DZ, Springer M. Barcoded microbial system for high-resolution object provenance. Science. 2020 06 05; 368(6495):1135-1140. PMID: 32499444.
    Citations:    Fields:    Translation:CellsPHPublic Health
  5. Stirling F, Silver PA. Controlling the Implementation of Transgenic Microbes: Are We Ready for What Synthetic Biology Has to Offer? Mol Cell. 2020 05 21; 78(4):614-623. PMID: 32442504.
    Citations:    Fields:    Translation:Humans
  6. Faktorová D, Nisbet RER, Fernández Robledo JA, Casacuberta E, Sudek L, Allen AE, Ares M, Aresté C, Balestreri C, Barbrook AC, Beardslee P, Bender S, Booth DS, Bouget FY, Bowler C, Breglia SA, Brownlee C, Burger G, Cerutti H, Cesaroni R, Chiurillo MA, Clemente T, Coles DB, Collier JL, Cooney EC, Coyne K, Docampo R, Dupont CL, Edgcomb V, Einarsson E, Elustondo PA, Federici F, Freire-Beneitez V, Freyria NJ, Fukuda K, García PA, Girguis PR, Gomaa F, Gornik SG, Guo J, Hampl V, Hanawa Y, Haro-Contreras ER, Hehenberger E, Highfield A, Hirakawa Y, Hopes A, Howe CJ, Hu I, Ibañez J, Irwin NAT, Ishii Y, Janowicz NE, Jones AC, Kachale A, Fujimura-Kamada K, Kaur B, Kaye JZ, Kazana E, Keeling PJ, King N, Klobutcher LA, Lander N, Lassadi I, Li Z, Lin S, Lozano JC, Luan F, Maruyama S, Matute T, Miceli C, Minagawa J, Moosburner M, Najle SR, Nanjappa D, Nimmo IC, Noble L, Novák Vanclová AMG, Nowacki M, Nuñez I, Pain A, Piersanti A, Pucciarelli S, Pyrih J, Rest JS, Rius M, Robertson D, Ruaud A, Ruiz-Trillo I, Sigg MA, Silver PA, Slamovits CH, Jason Smith G, Sprecher BN, Stern R, Swart EC, Tsaousis AD, Tsypin L, Turkewitz A, Turnšek J, Valach M, Vergé V, von Dassow P, von der Haar T, Waller RF, Wang L, Wen X, Wheeler G, Woods A, Zhang H, Mock T, Worden AZ, Lukeš J. Publisher Correction: Genetic tool development in marine protists: emerging model organisms for experimental cell biology. Nat Methods. 2020 05; 17(5):551. PMID: 32296171.
    Citations:    Fields:    
  7. Faktorová D, Nisbet RER, Fernández Robledo JA, Casacuberta E, Sudek L, Allen AE, Ares M, Aresté C, Balestreri C, Barbrook AC, Beardslee P, Bender S, Booth DS, Bouget FY, Bowler C, Breglia SA, Brownlee C, Burger G, Cerutti H, Cesaroni R, Chiurillo MA, Clemente T, Coles DB, Collier JL, Cooney EC, Coyne K, Docampo R, Dupont CL, Edgcomb V, Einarsson E, Elustondo PA, Federici F, Freire-Beneitez V, Freyria NJ, Fukuda K, García PA, Girguis PR, Gomaa F, Gornik SG, Guo J, Hampl V, Hanawa Y, Haro-Contreras ER, Hehenberger E, Highfield A, Hirakawa Y, Hopes A, Howe CJ, Hu I, Ibañez J, Irwin NAT, Ishii Y, Janowicz NE, Jones AC, Kachale A, Fujimura-Kamada K, Kaur B, Kaye JZ, Kazana E, Keeling PJ, King N, Klobutcher LA, Lander N, Lassadi I, Li Z, Lin S, Lozano JC, Luan F, Maruyama S, Matute T, Miceli C, Minagawa J, Moosburner M, Najle SR, Nanjappa D, Nimmo IC, Noble L, Novák Vanclová AMG, Nowacki M, Nuñez I, Pain A, Piersanti A, Pucciarelli S, Pyrih J, Rest JS, Rius M, Robertson D, Ruaud A, Ruiz-Trillo I, Sigg MA, Silver PA, Slamovits CH, Jason Smith G, Sprecher BN, Stern R, Swart EC, Tsaousis AD, Tsypin L, Turkewitz A, Turnšek J, Valach M, Vergé V, von Dassow P, von der Haar T, Waller RF, Wang L, Wen X, Wheeler G, Woods A, Zhang H, Mock T, Worden AZ, Lukeš J. Genetic tool development in marine protists: emerging model organisms for experimental cell biology. Nat Methods. 2020 05; 17(5):481-494. PMID: 32251396.
    Citations:    Fields:    Translation:Animals
  8. Nangle SN, Wolfson MY, Hartsough L, Ma NJ, Mason CE, Merighi M, Nathan V, Silver PA, Simon M, Swett J, Thompson DB, Ziesack M. The case for biotech on Mars. Nat Biotechnol. 2020 04; 38(4):401-407. PMID: 32265561.
    Citations: 1     Fields:    Translation:Humans
  9. Perez R, Luccioni M, Kamakaka R, Clamons S, Gaut N, Stirling F, Adamala KP, Silver PA, Endy D. Enabling community-based metrology for wood-degrading fungi. Fungal Biol Biotechnol. 2020; 7:2. PMID: 32206323.
    Citations: 1     
  10. Stirling F, Naydich A, Bramante J, Barocio R, Certo M, Wellington H, Redfield E, O'Keefe S, Gao S, Cusolito A, Way J, Silver P. Synthetic Cassettes for pH-Mediated Sensing, Counting, and Containment. Cell Rep. 2020 03 03; 30(9):3139-3148.e4. PMID: 32130913.
    Citations: 1     Fields:    
  11. Hsu BB, Way JC, Silver PA. Stable Neutralization of a Virulence Factor in Bacteria Using Temperate Phage in the Mammalian Gut. mSystems. 2020 Jan 28; 5(1). PMID: 31992629.
    Citations: 2     
  12. Tracey JC, Coronado M, Giessen TW, Lau MCY, Silver PA, Ward BB. The Discovery of Twenty-Eight New Encapsulin Sequences, Including Three in Anammox Bacteria. Sci Rep. 2019 12 27; 9(1):20122. PMID: 31882935.
    Citations:    Fields:    
  13. Lee J, Vernet A, Redfield K, Lu S, Ghiran IC, Way JC, Silver PA. Rational Design of a Bifunctional AND-Gate Ligand To Modulate Cell-Cell Interactions. ACS Synth Biol. 2020 02 21; 9(2):191-197. PMID: 31834794.
    Citations:    Fields:    
  14. Kim J, Zhou Y, Carlson PD, Teichmann M, Chaudhary S, Simmel FC, Silver PA, Collins JJ, Lucks JB, Yin P, Green AA. De novo-designed translation-repressing riboregulators for multi-input cellular logic. Nat Chem Biol. 2019 12; 15(12):1173-1182. PMID: 31686032.
    Citations: 5     Fields:    Translation:Cells
  15. Riglar DT, Richmond DL, Potvin-Trottier L, Verdegaal AA, Naydich AD, Bakshi S, Leoncini E, Lyon LG, Paulsson J, Silver PA. Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator. Nat Commun. 2019 10 11; 10(1):4665. PMID: 31604953.
    Citations: 4     Fields:    Translation:AnimalsCells
  16. Ziesack M, Gibson T, Oliver JKW, Shumaker AM, Hsu BB, Riglar DT, Giessen TW, DiBenedetto NV, Bry L, Way JC, Silver PA, Gerber GK. Engineered Interspecies Amino Acid Cross-Feeding Increases Population Evenness in a Synthetic Bacterial Consortium. mSystems. 2019 Aug 13; 4(4). PMID: 31409662.
    Citations: 5     
  17. Giessen TW, Orlando BJ, Verdegaal AA, Chambers MG, Gardener J, Bell DC, Birrane G, Liao M, Silver PA. Large protein organelles form a new iron sequestration system with high storage capacity. Elife. 2019 07 08; 8. PMID: 31282860.
    Citations: 1     Fields:    Translation:Cells
  18. Naydich AD, Nangle SN, Bues JJ, Trivedi D, Nissar N, Inniss MC, Niederhuber MJ, Way JC, Silver PA, Riglar DT. Synthetic Gene Circuits Enable Systems-Level Biosensor Trigger Discovery at the Host-Microbe Interface. mSystems. 2019 Jun 11; 4(4). PMID: 31186335.
    Citations: 3     
  19. Hsu BB, Gibson TE, Yeliseyev V, Liu Q, Lyon L, Bry L, Silver PA, Gerber GK. Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model. . 2019 Jun 12; 25(6):803-814.e5. PMID: 31175044.
    Citations: 23     Translation:AnimalsCells
  20. Cristea IM, Dorrestein PC, Eisen JA, Gilbert JA, Huber JA, Jansson JK, Knight R, Pollard KS, Raes J, Silver PA, Webster NS, Xu J. Early-Career Scientists Shaping the World. mSystems. 2019 May 07; 4(3). PMID: 31219787.
    Citations:    
  21. Chang TZ, Kuo J, Silver PA. Beyond the Four Bases: A Home Run for Synthetic Epigenetic Control? Mol Cell. 2019 04 04; 74(1):5-7. PMID: 30951651.
    Citations:    Fields:    Translation:HumansCells
  22. Shumaker AM, Laclare McEneany V, Coyne MJ, Silver PA, Comstock LE. Identification of a Fifth Antibacterial Toxin Produced by a Single Bacteroides fragilis Strain. J Bacteriol. 2019 04 15; 201(8). PMID: 30692177.
    Citations: 1     Fields:    Translation:Cells
  23. Libby EA, Silver PA. Harnessing undomesticated life. Nat Microbiol. 2019 02; 4(2):212-213. PMID: 30675034.
    Citations:    Fields:    Translation:Cells
  24. Tscherner M, Giessen TW, Markey L, Kumamoto CA, Silver PA. A Synthetic System That Senses Candida albicans and Inhibits Virulence Factors. ACS Synth Biol. 2019 02 15; 8(2):434-444. PMID: 30608638.
    Citations: 3     Fields:    Translation:Animals
  25. Ziesack M, Karrenbelt MAP, Bues J, Schaefer E, Silver P, Way J. Escherichia coli NGF-1, a Genetically Tractable, Efficiently Colonizing Murine Gut Isolate. Microbiol Resour Announc. 2018 Dec; 7(22). PMID: 30533859.
    Citations: 2     
  26. Stirling F, Bitzan L, O'Keefe S, Redfield E, Oliver JWK, Way J, Silver PA. Rational Design of Evolutionarily Stable Microbial Kill Switches. Mol Cell. 2018 10 18; 72(2):395. PMID: 30340025.
    Citations:    Fields:    
  27. Kim S, Kerns SJ, Ziesack M, Bry L, Gerber GK, Way JC, Silver PA. Quorum Sensing Can Be Repurposed To Promote Information Transfer between Bacteria in the Mammalian Gut. ACS Synth Biol. 2018 09 21; 7(9):2270-2281. PMID: 30125499.
    Citations: 4     Fields:    Translation:AnimalsCells
  28. Spady ES, Wyche TP, Rollins NJ, Clardy J, Way JC, Silver PA. Mammalian Cells Engineered To Produce New Steroids. Chembiochem. 2018 09 04; 19(17):1827-1833. PMID: 29931794.
    Citations:    Fields:    Translation:HumansCells
  29. Ziesack M, Rollins N, Shah A, Dusel B, Webster G, Silver PA, Way JC. Chimeric Fatty Acyl-Acyl Carrier Protein Thioesterases Provide Mechanistic Insight into Enzyme Specificity and Expression. Appl Environ Microbiol. 2018 05 15; 84(10). PMID: 29549102.
    Citations:    Fields:    Translation:Animals
  30. Lau YH, Giessen TW, Altenburg WJ, Silver PA. Prokaryotic nanocompartments form synthetic organelles in a eukaryote. Nat Commun. 2018 04 03; 9(1):1311. PMID: 29615617.
    Citations: 7     Fields:    Translation:AnimalsCells
  31. Riglar DT, Silver PA. Engineering bacteria for diagnostic and therapeutic applications. Nat Rev Microbiol. 2018 04; 16(4):214-225. PMID: 29398705.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  32. Stirling F, Bitzan L, O'Keefe S, Redfield E, Oliver JWK, Way J, Silver PA. Rational Design of Evolutionarily Stable Microbial Kill Switches. Mol Cell. 2017 Nov 16; 68(4):686-697.e3. PMID: 29149596.
    Citations: 8     Fields:    Translation:AnimalsCells
  33. Nangle SN, Sakimoto KK, Silver PA, Nocera DG. Biological-inorganic hybrid systems as a generalized platform for chemical production. Curr Opin Chem Biol. 2017 Dec; 41:107-113. PMID: 29136557.
    Citations:    Fields:    
  34. Kuo J, Stirling F, Lau YH, Shulgina Y, Way JC, Silver PA. Synthetic genome recoding: new genetic codes for new features. Curr Genet. 2018 Apr; 64(2):327-333. PMID: 28983660.
    Citations: 2     Fields:    Translation:Cells
  35. Niederhuber MJ, Lambert TJ, Yapp C, Silver PA, Polka JK. Superresolution microscopy of the ß-carboxysome reveals a homogeneous matrix. Mol Biol Cell. 2017 Oct 01; 28(20):2734-2745. PMID: 28963440.
    Citations: 2     Fields:    Translation:Cells
  36. Niederhuber MJ, Lambert TJ, Yapp C, Silver PA, Polka JK. Super-resolution microscopy of the ß-carboxysome reveals a homogenous matrix. Mol Biol Cell. 2017 Aug 09. PMID: 28794262.
    Citations:    
  37. Green AA, Kim J, Ma D, Silver PA, Collins JJ, Yin P. Complex cellular logic computation using ribocomputing devices. Nature. 2017 08 03; 548(7665):117-121. PMID: 28746304.
    Citations: 21     Fields:    Translation:Cells
  38. Lau YH, Stirling F, Kuo J, Karrenbelt MAP, Chan YA, Riesselman A, Horton CA, Schäfer E, Lips D, Weinstock MT, Gibson DG, Way JC, Silver PA. Large-scale recoding of a bacterial genome by iterative recombineering of synthetic DNA. Nucleic Acids Res. 2017 Jun 20; 45(11):6971-6980. PMID: 28499033.
    Citations: 12     Fields:    Translation:Cells
  39. Liu C, Sakimoto KK, Colón BC, Silver PA, Nocera DG. Ambient nitrogen reduction cycle using a hybrid inorganic-biological system. Proc Natl Acad Sci U S A. 2017 06 20; 114(25):6450-6455. PMID: 28588143.
    Citations: 9     Fields:    Translation:Cells
  40. Liu C, Nangle SN, Colón BC, Silver PA, Nocera DG. 13C-Labeling the carbon-fixation pathway of a highly efficient artificial photosynthetic system. Faraday Discuss. 2017 06 02; 198:529-537. PMID: 28294218.
    Citations: 1     Fields:    
  41. Riglar DT, Giessen TW, Baym M, Kerns SJ, Niederhuber MJ, Bronson RT, Kotula JW, Gerber GK, Way JC, Silver PA. Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation. Nat Biotechnol. 2017 Jul; 35(7):653-658. PMID: 28553941.
    Citations: 29     Fields:    Translation:AnimalsCells
  42. Brown DM, Chan YA, Desai PJ, Grzesik P, Oldfield LM, Vashee S, Way JC, Silver PA, Glass JI. Efficient size-independent chromosome delivery from yeast to cultured cell lines. Nucleic Acids Res. 2017 04 20; 45(7):e50. PMID: 27980064.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  43. Giessen TW, Silver PA. Widespread distribution of encapsulin nanocompartments reveals functional diversity. Nat Microbiol. 2017 Mar 06; 2:17029. PMID: 28263314.
    Citations: 13     Fields:    Translation:Cells
  44. Hays SG, Yan LLW, Silver PA, Ducat DC. Synthetic photosynthetic consortia define interactions leading to robustness and photoproduction. J Biol Eng. 2017; 11:4. PMID: 28127397.
    Citations: 12     
  45. Giessen TW, Silver PA. Engineering carbon fixation with artificial protein organelles. Curr Opin Biotechnol. 2017 08; 46:42-50. PMID: 28126670.
    Citations: 7     Fields:    Translation:AnimalsCells
  46. Liu X, Lopez PA, Giessen TW, Giles M, Way JC, Silver PA. Engineering Genetically-Encoded Mineralization and Magnetism via Directed Evolution. Sci Rep. 2016 11 29; 6:38019. PMID: 27897245.
    Citations: 4     Fields:    Translation:Cells
  47. Giessen TW, Silver PA. A Catalytic Nanoreactor Based on in Vivo Encapsulation of Multiple Enzymes in an Engineered Protein Nanocompartment. Chembiochem. 2016 10 17; 17(20):1931-1935. PMID: 27504846.
    Citations: 9     Fields:    Translation:Cells
  48. Myhrvold C, Polka JK, Silver PA. Synthetic Lipid-Containing Scaffolds Enhance Production by Colocalizing Enzymes. ACS Synth Biol. 2016 12 16; 5(12):1396-1403. PMID: 27487319.
    Citations: 5     Fields:    Translation:Cells
  49. Polka JK, Hays SG, Silver PA. Building Spatial Synthetic Biology with Compartments, Scaffolds, and Communities. Cold Spring Harb Perspect Biol. 2016 08 01; 8(8). PMID: 27270297.
    Citations: 9     Fields:    Translation:Cells
  50. Lee JW, Gyorgy A, Cameron DE, Pyenson N, Choi KR, Way JC, Silver PA, Del Vecchio D, Collins JJ. Creating Single-Copy Genetic Circuits. Mol Cell. 2016 07 21; 63(2):329-336. PMID: 27425413.
    Citations: 9     Fields:    Translation:Cells