Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Pamela A. Silver, Ph.D.


Available: 07/06/17, Expires: 07/05/19

We have general capabilities in construction and testing of targeted fusion proteins and also bacteria and mammalian cells engineered with complex genetic circuits. We seek students with interest in a particular disease that they want to treat. We currently are developing treatments for anemia, cancer, certain viruses and other diseases and disorders.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. T32GM080177 (MITCHISON, TIMOTHY J) Jul 1, 2010 - Jun 30, 2020
    Harvard Systems Biology Graduate Program
    Role: Co-Principal Investigator
  2. R01GM057476 (SILVER, PAMELA A.) May 1, 1998 - Apr 30, 2011
    Connecting the Genome to the Cytoplasm
    Role: Principal Investigator
  3. R37GM036373 (SILVER, PAMELA A) Jun 1, 1993 - Mar 31, 2013
    Transport of Proteins In and Out of the Nucleus
    Role: Principal Investigator
  4. R01GM047385 (SILVER, PAMELA A.) May 1, 1992 - May 31, 1997
    Role: Principal Investigator
  5. R01GM036373 (SILVER, PAMELA A) Apr 1, 1986 - Mar 31, 2017
    Designing Biological Circuits
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chang TZ, Kuo J, Silver PA. Beyond the Four Bases: A Home Run for Synthetic Epigenetic Control? Mol Cell. 2019 04 04; 74(1):5-7. PMID: 30951651.
  2. Shumaker AM, Laclare McEneany V, Coyne MJ, Silver PA, Comstock LE. Identification of a Fifth Antibacterial Toxin Produced by a Single Bacteroides fragilis Strain. J Bacteriol. 2019 Apr 15; 201(8). PMID: 30692177.
    Citations:    Fields:    
  3. Libby EA, Silver PA. Harnessing undomesticated life. Nat Microbiol. 2019 02; 4(2):212-213. PMID: 30675034.
    Citations:    Fields:    
  4. Tscherner M, Giessen TW, Markey L, Kumamoto CA, Silver PA. A Synthetic System That Senses Candida albicans and Inhibits Virulence Factors. ACS Synth Biol. 2019 Feb 15; 8(2):434-444. PMID: 30608638.
    Citations:    Fields:    
  5. Ziesack M, Karrenbelt MAP, Bues J, Schaefer E, Silver P, Way J. Escherichia coli NGF-1, a Genetically Tractable, Efficiently Colonizing Murine Gut Isolate. Microbiol Resour Announc. 2018 Dec; 7(22). PMID: 30533859.
  6. Stirling F, Bitzan L, O'Keefe S, Redfield E, Oliver JWK, Way J, Silver PA. Rational Design of Evolutionarily Stable Microbial Kill Switches. Mol Cell. 2018 10 18; 72(2):395. PMID: 30340025.
    Citations:    Fields:    
  7. Kim S, Kerns SJ, Ziesack M, Bry L, Gerber GK, Way JC, Silver PA. Quorum Sensing Can Be Repurposed To Promote Information Transfer between Bacteria in the Mammalian Gut. ACS Synth Biol. 2018 09 21; 7(9):2270-2281. PMID: 30125499.
    Citations:    Fields:    
  8. Spady ES, Wyche TP, Rollins NJ, Clardy J, Way JC, Silver PA. Mammalian Cells Engineered To Produce New Steroids. Chembiochem. 2018 Sep 04; 19(17):1827-1833. PMID: 29931794.
    Citations:    Fields:    
  9. Ziesack M, Rollins N, Shah A, Dusel B, Webster G, Silver PA, Way JC. Chimeric Fatty Acyl-Acyl Carrier Protein Thioesterases Provide Mechanistic Insight into Enzyme Specificity and Expression. Appl Environ Microbiol. 2018 May 15; 84(10). PMID: 29549102.
    Citations:    Fields:    
  10. Lau YH, Giessen TW, Altenburg WJ, Silver PA. Prokaryotic nanocompartments form synthetic organelles in a eukaryote. Nat Commun. 2018 04 03; 9(1):1311. PMID: 29615617.
    Citations: 3     Fields:    Translation:AnimalsCells
  11. Riglar DT, Silver PA. Engineering bacteria for diagnostic and therapeutic applications. Nat Rev Microbiol. 2018 Apr; 16(4):214-225. PMID: 29398705.
    Citations: 1     Fields:    
  12. Stirling F, Bitzan L, O'Keefe S, Redfield E, Oliver JWK, Way J, Silver PA. Rational Design of Evolutionarily Stable Microbial Kill Switches. Mol Cell. 2017 Nov 16; 68(4):686-697.e3. PMID: 29149596.
    Citations: 4     Fields:    Translation:AnimalsCells
  13. Nangle SN, Sakimoto KK, Silver PA, Nocera DG. Biological-inorganic hybrid systems as a generalized platform for chemical production. Curr Opin Chem Biol. 2017 Dec; 41:107-113. PMID: 29136557.
    Citations:    Fields:    
  14. Kuo J, Stirling F, Lau YH, Shulgina Y, Way JC, Silver PA. Synthetic genome recoding: new genetic codes for new features. Curr Genet. 2018 Apr; 64(2):327-333. PMID: 28983660.
    Citations:    Fields:    Translation:Cells
  15. Niederhuber MJ, Lambert TJ, Yapp C, Silver PA, Polka JK. Superresolution microscopy of the ß-carboxysome reveals a homogeneous matrix. Mol Biol Cell. 2017 Oct 01; 28(20):2734-2745. PMID: 28963440.
    Citations:    Fields:    Translation:Cells
  16. Niederhuber MJ, Lambert TJ, Yapp C, Silver PA, Polka JK. Super-resolution microscopy of the ß-carboxysome reveals a homogenous matrix. Mol Biol Cell. 2017 Aug 09. PMID: 28794262.
  17. Green AA, Kim J, Ma D, Silver PA, Collins JJ, Yin P. Complex cellular logic computation using ribocomputing devices. Nature. 2017 08 03; 548(7665):117-121. PMID: 28746304.
    Citations: 5     Fields:    Translation:Cells
  18. Lau YH, Stirling F, Kuo J, Karrenbelt MAP, Chan YA, Riesselman A, Horton CA, Schäfer E, Lips D, Weinstock MT, Gibson DG, Way JC, Silver PA. Large-scale recoding of a bacterial genome by iterative recombineering of synthetic DNA. Nucleic Acids Res. 2017 Jun 20; 45(11):6971-6980. PMID: 28499033.
    Citations: 8     Fields:    Translation:Cells
  19. Liu C, Sakimoto KK, Colón BC, Silver PA, Nocera DG. Ambient nitrogen reduction cycle using a hybrid inorganic-biological system. Proc Natl Acad Sci U S A. 2017 06 20; 114(25):6450-6455. PMID: 28588143.
    Citations: 2     Fields:    Translation:Cells
  20. Liu C, Nangle SN, Colón BC, Silver PA, Nocera DG. 13C-Labeling the carbon-fixation pathway of a highly efficient artificial photosynthetic system. Faraday Discuss. 2017 06 02; 198:529-537. PMID: 28294218.
    Citations:    Fields:    
  21. Riglar DT, Giessen TW, Baym M, Kerns SJ, Niederhuber MJ, Bronson RT, Kotula JW, Gerber GK, Way JC, Silver PA. Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation. Nat Biotechnol. 2017 Jul; 35(7):653-658. PMID: 28553941.
    Citations: 14     Fields:    Translation:AnimalsCells
  22. Brown DM, Chan YA, Desai PJ, Grzesik P, Oldfield LM, Vashee S, Way JC, Silver PA, Glass JI. Efficient size-independent chromosome delivery from yeast to cultured cell lines. Nucleic Acids Res. 2017 04 20; 45(7):e50. PMID: 27980064.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  23. Giessen TW, Silver PA. Widespread distribution of encapsulin nanocompartments reveals functional diversity. Nat Microbiol. 2017 Mar 06; 2:17029. PMID: 28263314.
    Citations: 4     Fields:    Translation:Cells
  24. Hays SG, Yan LLW, Silver PA, Ducat DC. Synthetic photosynthetic consortia define interactions leading to robustness and photoproduction. J Biol Eng. 2017; 11:4. PMID: 28127397.
    Citations: 3     
  25. Giessen TW, Silver PA. Engineering carbon fixation with artificial protein organelles. Curr Opin Biotechnol. 2017 08; 46:42-50. PMID: 28126670.
    Citations: 3     Fields:    Translation:AnimalsCells
  26. Liu X, Lopez PA, Giessen TW, Giles M, Way JC, Silver PA. Engineering Genetically-Encoded Mineralization and Magnetism via Directed Evolution. Sci Rep. 2016 11 29; 6:38019. PMID: 27897245.
    Citations: 1     Fields:    Translation:Cells
  27. Giessen TW, Silver PA. A Catalytic Nanoreactor Based on in Vivo Encapsulation of Multiple Enzymes in an Engineered Protein Nanocompartment. Chembiochem. 2016 10 17; 17(20):1931-1935. PMID: 27504846.
    Citations: 6     Fields:    Translation:Cells
  28. Myhrvold C, Polka JK, Silver PA. Synthetic Lipid-Containing Scaffolds Enhance Production by Colocalizing Enzymes. ACS Synth Biol. 2016 12 16; 5(12):1396-1403. PMID: 27487319.
    Citations: 3     Fields:    Translation:Cells
  29. Polka JK, Hays SG, Silver PA. Building Spatial Synthetic Biology with Compartments, Scaffolds, and Communities. Cold Spring Harb Perspect Biol. 2016 08 01; 8(8). PMID: 27270297.
    Citations: 5     Fields:    Translation:Cells
  30. Lee JW, Gyorgy A, Cameron DE, Pyenson N, Choi KR, Way JC, Silver PA, Del Vecchio D, Collins JJ. Creating Single-Copy Genetic Circuits. Mol Cell. 2016 07 21; 63(2):329-336. PMID: 27425413.
    Citations: 4     Fields:    Translation:Cells
  31. Giessen TW, Silver PA. Converting a Natural Protein Compartment into a Nanofactory for the Size-Constrained Synthesis of Antimicrobial Silver Nanoparticles. ACS Synth Biol. 2016 12 16; 5(12):1497-1504. PMID: 27276075.
    Citations: 2     Fields:    Translation:Cells
  32. Liu C, Colón BC, Ziesack M, Silver PA, Nocera DG. Water splitting-biosynthetic system with CO2 reduction efficiencies exceeding photosynthesis. Science. 2016 Jun 03; 352(6290):1210-3. PMID: 27257255.
    Citations: 21     Fields:    Translation:Cells
  33. Boeke JD, Church G, Hessel A, Kelley NJ, Arkin A, Cai Y, Carlson R, Chakravarti A, Cornish VW, Holt L, Isaacs FJ, Kuiken T, Lajoie M, Lessor T, Lunshof J, Maurano MT, Mitchell LA, Rine J, Rosser S, Sanjana NE, Silver PA, Valle D, Wang H, Way JC, Yang L. GENOME ENGINEERING. The Genome Project-Write. Science. 2016 Jul 08; 353(6295):126-7. PMID: 27256881.
    Citations: 18     Fields:    Translation:Humans
  34. Burrill DR, Vernet A, Collins JJ, Silver PA, Way JC. Targeted erythropoietin selectively stimulates red blood cell expansion in vivo. Proc Natl Acad Sci U S A. 2016 May 10; 113(19):5245-50. PMID: 27114509.
    Citations: 1     Fields:    Translation:HumansAnimals
  35. Polka JK, Silver PA. A Tunable Protein Piston That Breaks Membranes to Release Encapsulated Cargo. ACS Synth Biol. 2016 Apr 15; 5(4):303-11. PMID: 26814170.
    Citations: 4     Fields:    Translation:Cells
  36. Liu X, Hicks WM, Silver PA, Way JC. Engineering acyl carrier protein to enhance production of shortened fatty acids. Biotechnol Biofuels. 2016; 9:24. PMID: 26839587.
    Citations: 5     
  37. MacKellar D, Lieber L, Norman JS, Bolger A, Tobin C, Murray JW, Oksaksin M, Chang RL, Ford TJ, Nguyen PQ, Woodward J, Permingeat HR, Joshi NS, Silver PA, Usadel B, Rutherford AW, Friesen ML, Prell J. Streptomyces thermoautotrophicus does not fix nitrogen. Sci Rep. 2016 Feb 01; 6:20086. PMID: 26833023.
    Citations: 3     Fields:    Translation:Cells
  38. Biteen JS, Blainey PC, Cardon ZG, Chun M, Church GM, Dorrestein PC, Fraser SE, Gilbert JA, Jansson JK, Knight R, Miller JF, Ozcan A, Prather KA, Quake SR, Ruby EG, Silver PA, Taha S, van den Engh G, Weiss PS, Wong GC, Wright AT, Young TD. Tools for the Microbiome: Nano and Beyond. ACS Nano. 2016 Jan 26; 10(1):6-37. PMID: 26695070.
    Citations: 15     Fields:    Translation:HumansPHPublic Health
  39. Myhrvold C, Kotula JW, Hicks WM, Conway NJ, Silver PA. A distributed cell division counter reveals growth dynamics in the gut microbiota. Nat Commun. 2015 Nov 30; 6:10039. PMID: 26615910.
    Citations: 8     Fields:    Translation:HumansCells
  40. Giessen TW, Silver PA. Encapsulation as a Strategy for the Design of Biological Compartmentalization. J Mol Biol. 2016 Feb 27; 428(5 Pt B):916-27. PMID: 26403362.
    Citations: 3     Fields:    Translation:Cells
  41. Hays SG, Patrick WG, Ziesack M, Oxman N, Silver PA. Better together: engineering and application of microbial symbioses. Curr Opin Biotechnol. 2015 Dec; 36:40-9. PMID: 26319893.
    Citations: 16     Fields:    Translation:HumansAnimals
  42. Ford TJ, Silver PA. Synthetic biology expands chemical control of microorganisms. Curr Opin Chem Biol. 2015 Oct; 28:20-8. PMID: 26056951.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  43. Chang ZL, Silver PA, Chen YY. Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors. J Transl Med. 2015 May 20; 13:161. PMID: 25990251.
    Citations: 4     Fields:    Translation:HumansCells
  44. Torella JP, Gagliardi CJ, Chen JS, Bediako DK, Colón B, Way JC, Silver PA, Nocera DG. Efficient solar-to-fuels production from a hybrid microbial-water-splitting catalyst system. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2337-42. PMID: 25675518.
    Citations: 24     Fields:    Translation:Cells
  45. Myhrvold C, Silver PA. Using synthetic RNAs as scaffolds and regulators. Nat Struct Mol Biol. 2015 Jan; 22(1):8-10. PMID: 25565027.
    Citations: 2     Fields:    Translation:Cells
  46. Chen AH, Lubkowicz D, Yeong V, Chang RL, Silver PA. Transplantability of a circadian clock to a noncircadian organism. Sci Adv. 2015; 1(5). PMID: 26229984.
    Citations: 6     Fields:    
  47. Robinson-Mosher A, Chen JH, Way J, Silver PA. Designing cell-targeted therapeutic proteins reveals the interplay between domain connectivity and cell binding. Biophys J. 2014 Nov 18; 107(10):2456-66. PMID: 25418314.
    Citations: 1     Fields:    Translation:HumansCells
  48. Green AA, Silver PA, Collins JJ, Yin P. Toehold switches: de-novo-designed regulators of gene expression. Cell. 2014 Nov 06; 159(4):925-39. PMID: 25417166.
    Citations: 68     Fields:    Translation:Cells
  49. Polka JK, Silver PA. Induced sensitivity of Bacillus subtilis colony morphology to mechanical media compression. PeerJ. 2014; 2:e597. PMID: 25289183.
    Citations: 1     
  50. Torella JP, Lienert F, Boehm CR, Chen JH, Way JC, Silver PA. Unique nucleotide sequence-guided assembly of repetitive DNA parts for synthetic biology applications. Nat Protoc. 2014 Sep; 9(9):2075-89. PMID: 25101822.
    Citations: 8     Fields:    Translation:Cells
  51. Sachdeva G, Garg A, Godding D, Way JC, Silver PA. In vivo co-localization of enzymes on RNA scaffolds increases metabolic production in a geometrically dependent manner. Nucleic Acids Res. 2014 Aug; 42(14):9493-503. PMID: 25034694.
    Citations: 19     Fields:    Translation:Cells
  52. Silver PA, Way JC, Arnold FH, Meyerowitz JT. Synthetic biology: Engineering explored. Nature. 2014 May 08; 509(7499):166-7. PMID: 24805338.
    Citations: 7     Fields:    
  53. Mattozzi MD, Voges MJ, Silver PA, Way JC. Transient gene expression in tobacco using Gibson assembly and the Gene Gun. J Vis Exp. 2014 Apr 18; (86). PMID: 24796418.
    Citations: 1     Fields:    Translation:Animals
  54. Way JC, Collins JJ, Keasling JD, Silver PA. Integrating biological redesign: where synthetic biology came from and where it needs to go. Cell. 2014 Mar 27; 157(1):151-61. PMID: 24679533.
    Citations: 50     Fields:    Translation:AnimalsCells
  55. Kotula JW, Kerns SJ, Shaket LA, Siraj L, Collins JJ, Way JC, Silver PA. Programmable bacteria detect and record an environmental signal in the mammalian gut. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):4838-43. PMID: 24639514.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  56. Weyn-Vanhentenryck SM, Mele A, Yan Q, Sun S, Farny N, Zhang Z, Xue C, Herre M, Silver PA, Zhang MQ, Krainer AR, Darnell RB, Zhang C. HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism. Cell Rep. 2014 Mar 27; 6(6):1139-1152. PMID: 24613350.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  57. Lienert F, Lohmueller JJ, Garg A, Silver PA. Synthetic biology in mammalian cells: next generation research tools and therapeutics. Nat Rev Mol Cell Biol. 2014 Feb; 15(2):95-107. PMID: 24434884.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  58. Polka JK, Silver PA. Building synthetic cellular organization. Mol Biol Cell. 2013 Dec; 24(23):3585-7. PMID: 24288075.
    Citations: 1     Fields:    Translation:Cells
  59. Wintermute EH, Lieberman TD, Silver PA. An objective function exploiting suboptimal solutions in metabolic networks. BMC Syst Biol. 2013 Oct 03; 7:98. PMID: 24088221.
    Citations: 5     Fields:    Translation:Cells
  60. Torella JP, Boehm CR, Lienert F, Chen JH, Way JC, Silver PA. Rapid construction of insulated genetic circuits via synthetic sequence-guided isothermal assembly. Nucleic Acids Res. 2014 Jan; 42(1):681-9. PMID: 24078086.
    Citations: 13     Fields:    Translation:Cells
  61. Inniss MC, Silver PA. Building synthetic memory. Curr Biol. 2013 Sep 09; 23(17):R812-6. PMID: 24028965.
    Citations: 11     Fields:    Translation:Cells
  62. Voges MJ, Silver PA, Way JC, Mattozzi MD. Targeting a heterologous protein to multiple plant organelles via rationally designed 5' mRNA tags. J Biol Eng. 2013 Sep 08; 7(1):20. PMID: 24011257.
    Citations: 3     
  63. Chen AH, Robinson-Mosher A, Savage DF, Silver PA, Polka JK. The bacterial carbon-fixing organelle is formed by shell envelopment of preassembled cargo. PLoS One. 2013; 8(9):e76127. PMID: 24023971.
    Citations: 25     Fields:    Translation:Cells
  64. Lienert F, Torella JP, Chen JH, Norsworthy M, Richardson RR, Silver PA. Two- and three-input TALE-based AND logic computation in embryonic stem cells. Nucleic Acids Res. 2013 Nov; 41(21):9967-75. PMID: 23982518.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  65. Myhrvold C, Dai M, Silver PA, Yin P. Isothermal self-assembly of complex DNA structures under diverse and biocompatible conditions. Nano Lett. 2013 Sep 11; 13(9):4242-8. PMID: 23978049.
    Citations: 10     Fields:    Translation:Cells
  66. Torella JP, Ford TJ, Kim SN, Chen AM, Way JC, Silver PA. Tailored fatty acid synthesis via dynamic control of fatty acid elongation. Proc Natl Acad Sci U S A. 2013 Jul 09; 110(28):11290-5. PMID: 23798438.
    Citations: 41     Fields:    Translation:Cells
  67. Robinson-Mosher A, Shinar T, Silver PA, Way J. Dynamics simulations for engineering macromolecular interactions. Chaos. 2013 Jun; 23(2):025110. PMID: 23822508.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  68. Selgrade DF, Lohmueller JJ, Lienert F, Silver PA. Protein scaffold-activated protein trans-splicing in mammalian cells. J Am Chem Soc. 2013 May 22; 135(20):7713-9. PMID: 23621664.
    Citations: 12     Fields:    Translation:HumansCells
  69. Wang Q, Moore MJ, Adelmant G, Marto JA, Silver PA. PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth. Genes Dev. 2013 Mar 15; 27(6):615-26. PMID: 23512658.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  70. Mattozzi Md, Ziesack M, Voges MJ, Silver PA, Way JC. Expression of the sub-pathways of the Chloroflexus aurantiacus 3-hydroxypropionate carbon fixation bicycle in E. coli: Toward horizontal transfer of autotrophic growth. Metab Eng. 2013 Mar; 16:130-9. PMID: 23376595.
    Citations: 10     Fields:    Translation:Cells
  71. Chen AH, Afonso B, Silver PA, Savage DF. Spatial and temporal organization of chromosome duplication and segregation in the cyanobacterium Synechococcus elongatus PCC 7942. PLoS One. 2012; 7(10):e47837. PMID: 23112856.
    Citations: 10     Fields:    Translation:Cells
  72. Delebecque CJ, Silver PA, Lindner AB. Designing and using RNA scaffolds to assemble proteins in vivo. Nat Protoc. 2012 Oct; 7(10):1797-807. PMID: 22955695.
    Citations: 13     Fields:    Translation:Cells
  73. Chen AH, Silver PA. Designing biological compartmentalization. Trends Cell Biol. 2012 Dec; 22(12):662-70. PMID: 22841504.
    Citations: 27     Fields:    Translation:Cells
  74. Chen AJ, Paik JH, Zhang H, Shukla SA, Mortensen R, Hu J, Ying H, Hu B, Hurt J, Farny N, Dong C, Xiao Y, Wang YA, Silver PA, Chin L, Vasudevan S, Depinho RA. STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes Dev. 2012 Jul 01; 26(13):1459-72. PMID: 22751500.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  75. Burrill DR, Inniss MC, Boyle PM, Silver PA. Synthetic memory circuits for tracking human cell fate. Genes Dev. 2012 Jul 01; 26(13):1486-97. PMID: 22751502.
    Citations: 20 &nbs