Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Pamela A. Silver, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. T32GM080177 (MITCHISON, TIMOTHY J) Jul 1, 2010 - Jun 30, 2020
    NIH
    Harvard Systems Biology Graduate Program
    Role: Co-Principal Investigator
  2. R01GM057476 (SILVER, PAMELA A) May 1, 1998 - Apr 30, 2011
    NIH
    Connecting the Genome to the Cytoplasm
    Role: Principal Investigator
  3. R37GM036373 (SILVER, PAMELA A) Jun 1, 1993 - Mar 31, 2013
    NIH
    Transport of Proteins In and Out of the Nucleus
    Role: Principal Investigator
  4. R01GM047385 (SILVER, PAMELA A.) May 1, 1992 - May 31, 1997
    NIH
    EUKARYOTIC DNA J PROTEINS THAT REGULATE HSP70 ACTION
    Role: Principal Investigator
  5. R01GM036373 (SILVER, PAMELA A.) Apr 1, 1986 - Mar 31, 2018
    NIH
    Designing Biological Circuits
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Riglar DT, Richmond DL, Potvin-Trottier L, Verdegaal AA, Naydich AD, Bakshi S, Leoncini E, Lyon LG, Paulsson J, Silver PA. Author Correction: Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator. Nat Commun. 2021 Mar 16; 12(1):1818. PMID: 33727556.
    Citations:    Fields:    
  2. Altenburg WJ, Rollins N, Silver PA, Giessen TW. Exploring targeting peptide-shell interactions in encapsulin nanocompartments. Sci Rep. 2021 Mar 02; 11(1):4951. PMID: 33654191.
    Citations:    Fields:    
  3. Hsu BB, Plant IN, Lyon L, Anastassacos FM, Way JC, Silver PA. In situ reprogramming of gut bacteria by oral delivery. Nat Commun. 2020 10 06; 11(1):5030. PMID: 33024097.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Nangle SN, Ziesack M, Buckley S, Trivedi D, Loh DM, Nocera DG, Silver PA. Valorization of CO2 through lithoautotrophic production of sustainable chemicals in Cupriavidus necator. Metab Eng. 2020 11; 62:207-220. PMID: 32961296.
    Citations:    Fields:    
  5. Kuo J, Yuan R, Sánchez C, Paulsson J, Silver PA. Toward a translationally independent RNA-based synthetic oscillator using deactivated CRISPR-Cas. Nucleic Acids Res. 2020 08 20; 48(14):8165-8177. PMID: 32609820.
    Citations: 1     Fields:    Translation:Cells
  6. Qian J, Lu ZX, Mancuso CP, Jhuang HY, Del Carmen Barajas-Ornelas R, Boswell SA, Ramírez-Guadiana FH, Jones V, Sonti A, Sedlack K, Artzi L, Jung G, Arammash M, Pettit ME, Melfi M, Lyon L, Owen SV, Baym M, Khalil AS, Silver PA, Rudner DZ, Springer M. Barcoded microbial system for high-resolution object provenance. Science. 2020 06 05; 368(6495):1135-1140. PMID: 32499444.
    Citations: 4     Fields:    Translation:CellsPHPublic Health
  7. Stirling F, Silver PA. Controlling the Implementation of Transgenic Microbes: Are We Ready for What Synthetic Biology Has to Offer? Mol Cell. 2020 05 21; 78(4):614-623. PMID: 32442504.
    Citations:    Fields:    Translation:Humans
  8. Faktorová D, Nisbet RER, Fernández Robledo JA, Casacuberta E, Sudek L, Allen AE, Ares M, Aresté C, Balestreri C, Barbrook AC, Beardslee P, Bender S, Booth DS, Bouget FY, Bowler C, Breglia SA, Brownlee C, Burger G, Cerutti H, Cesaroni R, Chiurillo MA, Clemente T, Coles DB, Collier JL, Cooney EC, Coyne K, Docampo R, Dupont CL, Edgcomb V, Einarsson E, Elustondo PA, Federici F, Freire-Beneitez V, Freyria NJ, Fukuda K, García PA, Girguis PR, Gomaa F, Gornik SG, Guo J, Hampl V, Hanawa Y, Haro-Contreras ER, Hehenberger E, Highfield A, Hirakawa Y, Hopes A, Howe CJ, Hu I, Ibañez J, Irwin NAT, Ishii Y, Janowicz NE, Jones AC, Kachale A, Fujimura-Kamada K, Kaur B, Kaye JZ, Kazana E, Keeling PJ, King N, Klobutcher LA, Lander N, Lassadi I, Li Z, Lin S, Lozano JC, Luan F, Maruyama S, Matute T, Miceli C, Minagawa J, Moosburner M, Najle SR, Nanjappa D, Nimmo IC, Noble L, Novák Vanclová AMG, Nowacki M, Nuñez I, Pain A, Piersanti A, Pucciarelli S, Pyrih J, Rest JS, Rius M, Robertson D, Ruaud A, Ruiz-Trillo I, Sigg MA, Silver PA, Slamovits CH, Jason Smith G, Sprecher BN, Stern R, Swart EC, Tsaousis AD, Tsypin L, Turkewitz A, Turnšek J, Valach M, Vergé V, von Dassow P, von der Haar T, Waller RF, Wang L, Wen X, Wheeler G, Woods A, Zhang H, Mock T, Worden AZ, Lukeš J. Publisher Correction: Genetic tool development in marine protists: emerging model organisms for experimental cell biology. Nat Methods. 2020 05; 17(5):551. PMID: 32296171.
    Citations:    Fields:    
  9. Faktorová D, Nisbet RER, Fernández Robledo JA, Casacuberta E, Sudek L, Allen AE, Ares M, Aresté C, Balestreri C, Barbrook AC, Beardslee P, Bender S, Booth DS, Bouget FY, Bowler C, Breglia SA, Brownlee C, Burger G, Cerutti H, Cesaroni R, Chiurillo MA, Clemente T, Coles DB, Collier JL, Cooney EC, Coyne K, Docampo R, Dupont CL, Edgcomb V, Einarsson E, Elustondo PA, Federici F, Freire-Beneitez V, Freyria NJ, Fukuda K, García PA, Girguis PR, Gomaa F, Gornik SG, Guo J, Hampl V, Hanawa Y, Haro-Contreras ER, Hehenberger E, Highfield A, Hirakawa Y, Hopes A, Howe CJ, Hu I, Ibañez J, Irwin NAT, Ishii Y, Janowicz NE, Jones AC, Kachale A, Fujimura-Kamada K, Kaur B, Kaye JZ, Kazana E, Keeling PJ, King N, Klobutcher LA, Lander N, Lassadi I, Li Z, Lin S, Lozano JC, Luan F, Maruyama S, Matute T, Miceli C, Minagawa J, Moosburner M, Najle SR, Nanjappa D, Nimmo IC, Noble L, Novák Vanclová AMG, Nowacki M, Nuñez I, Pain A, Piersanti A, Pucciarelli S, Pyrih J, Rest JS, Rius M, Robertson D, Ruaud A, Ruiz-Trillo I, Sigg MA, Silver PA, Slamovits CH, Jason Smith G, Sprecher BN, Stern R, Swart EC, Tsaousis AD, Tsypin L, Turkewitz A, Turnšek J, Valach M, Vergé V, von Dassow P, von der Haar T, Waller RF, Wang L, Wen X, Wheeler G, Woods A, Zhang H, Mock T, Worden AZ, Lukeš J. Genetic tool development in marine protists: emerging model organisms for experimental cell biology. Nat Methods. 2020 05; 17(5):481-494. PMID: 32251396.
    Citations: 5     Fields:    Translation:Animals
  10. Nangle SN, Wolfson MY, Hartsough L, Ma NJ, Mason CE, Merighi M, Nathan V, Silver PA, Simon M, Swett J, Thompson DB, Ziesack M. The case for biotech on Mars. Nat Biotechnol. 2020 04; 38(4):401-407. PMID: 32265561.
    Citations: 2     Fields:    Translation:Humans
  11. Perez R, Luccioni M, Kamakaka R, Clamons S, Gaut N, Stirling F, Adamala KP, Silver PA, Endy D. Enabling community-based metrology for wood-degrading fungi. Fungal Biol Biotechnol. 2020; 7:2. PMID: 32206323.
    Citations: 2     
  12. Stirling F, Naydich A, Bramante J, Barocio R, Certo M, Wellington H, Redfield E, O'Keefe S, Gao S, Cusolito A, Way J, Silver P. Synthetic Cassettes for pH-Mediated Sensing, Counting, and Containment. Cell Rep. 2020 03 03; 30(9):3139-3148.e4. PMID: 32130913.
    Citations: 1     Fields:    Translation:Cells
  13. Hsu BB, Way JC, Silver PA. Stable Neutralization of a Virulence Factor in Bacteria Using Temperate Phage in the Mammalian Gut. mSystems. 2020 Jan 28; 5(1). PMID: 31992629.
    Citations: 5     
  14. Tracey JC, Coronado M, Giessen TW, Lau MCY, Silver PA, Ward BB. The Discovery of Twenty-Eight New Encapsulin Sequences, Including Three in Anammox Bacteria. Sci Rep. 2019 12 27; 9(1):20122. PMID: 31882935.
    Citations: 2     Fields:    Translation:CellsPHPublic Health
  15. Lee J, Vernet A, Redfield K, Lu S, Ghiran IC, Way JC, Silver PA. Rational Design of a Bifunctional AND-Gate Ligand To Modulate Cell-Cell Interactions. ACS Synth Biol. 2020 02 21; 9(2):191-197. PMID: 31834794.
    Citations:    Fields:    Translation:HumansAnimalsCells
  16. Kim J, Zhou Y, Carlson PD, Teichmann M, Chaudhary S, Simmel FC, Silver PA, Collins JJ, Lucks JB, Yin P, Green AA. De novo-designed translation-repressing riboregulators for multi-input cellular logic. Nat Chem Biol. 2019 12; 15(12):1173-1182. PMID: 31686032.
    Citations: 11     Fields:    Translation:Cells
  17. Riglar DT, Richmond DL, Potvin-Trottier L, Verdegaal AA, Naydich AD, Bakshi S, Leoncini E, Lyon LG, Paulsson J, Silver PA. Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator. Nat Commun. 2019 10 11; 10(1):4665. PMID: 31604953.
    Citations: 9     Fields:    Translation:AnimalsCells
  18. Ziesack M, Gibson T, Oliver JKW, Shumaker AM, Hsu BB, Riglar DT, Giessen TW, DiBenedetto NV, Bry L, Way JC, Silver PA, Gerber GK. Engineered Interspecies Amino Acid Cross-Feeding Increases Population Evenness in a Synthetic Bacterial Consortium. mSystems. 2019 Aug 13; 4(4). PMID: 31409662.
    Citations: 9     
  19. Giessen TW, Orlando BJ, Verdegaal AA, Chambers MG, Gardener J, Bell DC, Birrane G, Liao M, Silver PA. Large protein organelles form a new iron sequestration system with high storage capacity. Elife. 2019 07 08; 8. PMID: 31282860.
    Citations: 8     Fields:    Translation:Cells
  20. Naydich AD, Nangle SN, Bues JJ, Trivedi D, Nissar N, Inniss MC, Niederhuber MJ, Way JC, Silver PA, Riglar DT. Synthetic Gene Circuits Enable Systems-Level Biosensor Trigger Discovery at the Host-Microbe Interface. mSystems. 2019 Jun 11; 4(4). PMID: 31186335.
    Citations: 6     
  21. Hsu BB, Gibson TE, Yeliseyev V, Liu Q, Lyon L, Bry L, Silver PA, Gerber GK. Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model. . 2019 Jun 12; 25(6):803-814.e5. PMID: 31175044.
    Citations: 55     Translation:AnimalsCells
  22. Cristea IM, Dorrestein PC, Eisen JA, Gilbert JA, Huber JA, Jansson JK, Knight R, Pollard KS, Raes J, Silver PA, Webster NS, Xu J. Early-Career Scientists Shaping the World. mSystems. 2019 May 07; 4(3). PMID: 31219787.
    Citations:    
  23. Chang TZ, Kuo J, Silver PA. Beyond the Four Bases: A Home Run for Synthetic Epigenetic Control? Mol Cell. 2019 04 04; 74(1):5-7. PMID: 30951651.
    Citations:    Fields:    Translation:HumansCells
  24. Shumaker AM, Laclare McEneany V, Coyne MJ, Silver PA, Comstock LE. Identification of a Fifth Antibacterial Toxin Produced by a Single Bacteroides fragilis Strain. J Bacteriol. 2019 04 15; 201(8). PMID: 30692177.
    Citations: 2     Fields:    Translation:Cells
  25. Libby EA, Silver PA. Harnessing undomesticated life. Nat Microbiol. 2019 02; 4(2):212-213. PMID: 30675034.
    Citations:    Fields:    Translation:Cells
  26. Tscherner M, Giessen TW, Markey L, Kumamoto CA, Silver PA. A Synthetic System That Senses Candida albicans and Inhibits Virulence Factors. ACS Synth Biol. 2019 02 15; 8(2):434-444. PMID: 30608638.
    Citations: 4     Fields:    Translation:Animals
  27. Ziesack M, Karrenbelt MAP, Bues J, Schaefer E, Silver P, Way J. Escherichia coli NGF-1, a Genetically Tractable, Efficiently Colonizing Murine Gut Isolate. Microbiol Resour Announc. 2018 Dec; 7(22). PMID: 30533859.
    Citations: 2     
  28. Stirling F, Bitzan L, O'Keefe S, Redfield E, Oliver JWK, Way J, Silver PA. Rational Design of Evolutionarily Stable Microbial Kill Switches. Mol Cell. 2018 10 18; 72(2):395. PMID: 30340025.
    Citations:    Fields:    
  29. Kim S, Kerns SJ, Ziesack M, Bry L, Gerber GK, Way JC, Silver PA. Quorum Sensing Can Be Repurposed To Promote Information Transfer between Bacteria in the Mammalian Gut. ACS Synth Biol. 2018 09 21; 7(9):2270-2281. PMID: 30125499.
    Citations: 5     Fields:    Translation:AnimalsCells
  30. Spady ES, Wyche TP, Rollins NJ, Clardy J, Way JC, Silver PA. Mammalian Cells Engineered To Produce New Steroids. Chembiochem. 2018 09 04; 19(17):1827-1833. PMID: 29931794.
    Citations:    Fields:    Translation:HumansCells
  31. Ziesack M, Rollins N, Shah A, Dusel B, Webster G, Silver PA, Way JC. Chimeric Fatty Acyl-Acyl Carrier Protein Thioesterases Provide Mechanistic Insight into Enzyme Specificity and Expression. Appl Environ Microbiol. 2018 05 15; 84(10). PMID: 29549102.
    Citations:    Fields:    Translation:Animals
  32. Lau YH, Giessen TW, Altenburg WJ, Silver PA. Prokaryotic nanocompartments form synthetic organelles in a eukaryote. Nat Commun. 2018 04 03; 9(1):1311. PMID: 29615617.
    Citations: 14     Fields:    Translation:AnimalsCells
  33. Riglar DT, Silver PA. Engineering bacteria for diagnostic and therapeutic applications. Nat Rev Microbiol. 2018 04; 16(4):214-225. PMID: 29398705.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  34. Stirling F, Bitzan L, O'Keefe S, Redfield E, Oliv