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Jeffrey Isaac Zwicker, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01HL143365 (ZWICKER, JEFFREY) Aug 1, 2018 - Jul 31, 2023
    NIH/NHLBI
    Biomarkers and mechanisms in cancer associated thrombosis
    Role: Principal Investigator
  2. R34HL135226 (ZWICKER, JEFFREY) Jul 5, 2017 - Jun 30, 2020
    NIH/NHLBI
    Thromboprophylaxis with rosuvastatin following surgery for ovarian cancer
    Role: Principal Investigator
  3. R34HL127156 (ZWICKER, JEFFREY) Feb 10, 2016 - Jan 31, 2019
    NIH/NHLBI
    Risk-adapted thromboprophylaxis of hospitalized cancer patients
    Role: Co-Principal Investigator
  4. U54HL112302 (FURIE, BRUCE) Sep 1, 2012 - Apr 30, 2017
    NIH/NHLBI
    Protein disulfide isomerases: A new class of antithrombotic targets
    Role: Co-Investigator
  5. K23HL084052 (ZWICKER, JEFFREY) Feb 5, 2007 - Dec 31, 2012
    NIH/NHLBI
    Bloodborne tissue factor-bearing microparticles in Trousseau's syndrome
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Carney BJ, Uhlmann EJ, Puligandla M, Mantia C, Weber GM, Neuberg DS, Zwicker JI. Intracranial hemorrhage with direct oral anticoagulants in patients with brain tumors. J Thromb Haemost. 2019 Jan; 17(1):72-76. PMID: 30450803.
    View in: PubMed
  2. Kraaijpoel N, Di Nisio M, Mulder FI, van Es N, Beyer-Westendorf J, Carrier M, Garcia D, Grosso M, Kakkar AK, Mercuri MF, Middeldorp S, Hernandez CR, Santamaria A, Schwocho L, Segers A, Verhamme P, Wang TF, Weitz JI, Zhang G, Zwicker JI, Büller HR, Raskob GE. Clinical Impact of Bleeding in Cancer-Associated Venous Thromboembolism: Results from the Hokusai VTE Cancer Study. Thromb Haemost. 2018 Aug; 118(8):1439-1449. PMID: 30060256.
    View in: PubMed
  3. Samuelson Bannow BR, Lee AYY, Khorana AA, Zwicker JI, Noble S, Ay C, Carrier M. Management of anticoagulation for cancer-associated thrombosis in patients with thrombocytopenia: A systematic review. Res Pract Thromb Haemost. 2018 Oct; 2(4):664-669. PMID: 30349884.
    View in: PubMed
  4. Samuelson Bannow BT, Lee A, Khorana AA, Zwicker JI, Noble S, Ay C, Carrier M. Management of cancer-associated thrombosis in patients with thrombocytopenia: guidance from the SSC of the ISTH. J Thromb Haemost. 2018 Jun; 16(6):1246-1249. PMID: 29737593.
    View in: PubMed
  5. Stopa JD, Zwicker JI. The intersection of protein disulfide isomerase and cancer associated thrombosis. Thromb Res. 2018 04; 164 Suppl 1:S130-S135. PMID: 29703471.
    View in: PubMed
  6. Raskob GE, van Es N, Verhamme P, Carrier M, Di Nisio M, Garcia D, Grosso MA, Kakkar AK, Kovacs MJ, Mercuri MF, Meyer G, Segers A, Shi M, Wang TF, Yeo E, Zhang G, Zwicker JI, Weitz JI, Büller HR. Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism. N Engl J Med. 2018 Feb 15; 378(7):615-624. PMID: 29231094.
    View in: PubMed
  7. Mantia C, Uhlmann EJ, Puligandla M, Weber GM, Neuberg D, Zwicker JI. Predicting the higher rate of intracranial hemorrhage in glioma patients receiving therapeutic enoxaparin. Blood. 2017 06 22; 129(25):3379-3385. PMID: 28468796.
    View in: PubMed
  8. Zwicker JI. Risking thromboembolism: podoplanin and glioma. Blood. 2017 03 30; 129(13):1742-1743. PMID: 28360357.
    View in: PubMed
  9. Stopa JD, Neuberg D, Puligandla M, Furie B, Flaumenhaft R, Zwicker JI. Protein disulfide isomerase inhibition blocks thrombin generation in humans by interfering with platelet factor V activation. JCI Insight. 2017 Jan 12; 2(1):e89373. PMID: 28097231.
    View in: PubMed
  10. Rosenblatt J, Stone RM, Uhl L, Neuberg D, Joyce R, Levine JD, Arnason J, McMasters M, Luptakova K, Jain S, Zwicker JI, Hamdan A, Boussiotis V, Steensma DP, DeAngelo DJ, Galinsky I, Dutt PS, Logan E, Bryant MP, Stroopinsky D, Werner L, Palmer K, Coll M, Washington A, Cole L, Kufe D, Avigan D. Individualized vaccination of AML patients in remission is associated with induction of antileukemia immunity and prolonged remissions. Sci Transl Med. 2016 12 07; 8(368):368ra171. PMID: 27928025.
    View in: PubMed
  11. Zwicker JI. Scattering the spotlight on microparticles. J Thromb Haemost. 2017 01; 15(1):185-186. PMID: 27778450.
    View in: PubMed
  12. Zwicker JI, Carrier M. A meta-analysis of intracranial hemorrhage in patients with brain tumors receiving therapeutic anticoagulation: reply. J Thromb Haemost. 2016 10; 14(10):2082. PMID: 27477626.
    View in: PubMed
  13. Zwicker JI, Karp Leaf R, Carrier M. A meta-analysis of intracranial hemorrhage in patients with brain tumors receiving therapeutic anticoagulation. J Thromb Haemost. 2016 09; 14(9):1736-40. PMID: 27306689.
    View in: PubMed
  14. Weinstock MJ, Uhlmann EJ, Zwicker JI. Intracranial hemorrhage in cancer patients treated with anticoagulation. Thromb Res. 2016 Apr; 140 Suppl 1:S60-5. PMID: 27067980.
    View in: PubMed
  15. Galinski CN, Zwicker JI, Kennedy DR. Revisiting the mechanistic basis of the French Paradox: Red wine inhibits the activity of protein disulfide isomerase in vitro. Thromb Res. 2016 Jan; 137:169-73. PMID: 26585763; PMCID: PMC4706467 [Available on 01/01/17].
  16. Donato J, Campigotto F, Uhlmann EJ, Coletti E, Neuberg D, Weber GM, Zwicker JI. Intracranial hemorrhage in patients with brain metastases treated with therapeutic enoxaparin: a matched cohort study. Blood. 2015 Jul 23; 126(4):494-9. PMID: 25987658; PMCID: PMC4548746.
  17. Arnason JE, Luptakova K, Rosenblatt J, Tzachanis D, Avigan D, Zwicker JI, Levine J, Kim M, Parker JA, Grant B, Joyce RM. Yttrium-90 ibritumomab tiuxetan followed by rituximab maintenance as treatment for patients with diffuse large B-cell lymphoma are not candidates for autologous stem cell transplant. Acta Haematol. 2015; 133(4):347-53. PMID: 25677780.
    View in: PubMed
  18. Khorana AA, Zwicker JI, Connolly GC, Pabinger I. Prevention of venous thromboembolism in cancer outpatients: guidance from the SSC of the ISTH: reply. J Thromb Haemost. 2015 Feb; 13(2):325-6. PMID: 25408162.
    View in: PubMed
  19. Shields K, Cumming M, Rios J, Wong MT, Zwicker JI, Stramer SL, Alonso CD. Transfusion-associated Anaplasma phagocytophilum infection in a pregnant patient with thalassemia trait: a case report. Transfusion. 2015 Apr; 55(4):719-25. PMID: 25385549.
    View in: PubMed
  20. Carrier M, Khorana AA, Zwicker JI. The reply. Am J Med. 2014 Oct; 127(10):e13. PMID: 25311068.
    View in: PubMed
  21. Khorana AA, Otten HM, Zwicker JI, Connolly GC, Bancel DF, Pabinger I. Prevention of venous thromboembolism in cancer outpatients: guidance from the SSC of the ISTH. J Thromb Haemost. 2014 Nov; 12(11):1928-31. PMID: 25208230.
    View in: PubMed
  22. Zwicker JI, Bauer KA. How long is long enough? Extended anticoagulation for the treatment of cancer-associated deep vein thrombosis. J Clin Oncol. 2014 Nov 10; 32(32):3596-9. PMID: 25267753.
    View in: PubMed
  23. Flaumenhaft R, Furie B, Zwicker JI. Therapeutic implications of protein disulfide isomerase inhibition in thrombotic disease. Arterioscler Thromb Vasc Biol. 2015 Jan; 35(1):16-23. PMID: 25104801; PMCID: PMC4270882.
  24. Carrier M, Khorana AA, Zwicker JI. The reply. Am J Med. 2014 Jul; 127(7):e35. PMID: 24970611.
    View in: PubMed
  25. Zwicker JI, Rojan A, Campigotto F, Rehman N, Funches R, Connolly G, Webster J, Aggarwal A, Mobarek D, Faselis C, Neuberg D, Rickles FR, Wun T, Streiff MB, Khorana AA. Pattern of frequent but nontargeted pharmacologic thromboprophylaxis for hospitalized patients with cancer at academic medical centers: a prospective, cross-sectional, multicenter study. J Clin Oncol. 2014 Jun 10; 32(17):1792-6. PMID: 24799475; PMCID: PMC4039867.
  26. Zwicker JI, Connolly G, Carrier M, Kamphuisen PW, Lee AY. Catheter-associated deep vein thrombosis of the upper extremity in cancer patients: guidance from the SSC of the ISTH. J Thromb Haemost. 2014 May; 12(5):796-800. PMID: 24548519.
    View in: PubMed
  27. Zwicker JI. Unconventional approaches to the prevention of cancer associated thrombosis. Thromb Res. 2014 May; 133 Suppl 2:S44-8. PMID: 24862145.
    View in: PubMed
  28. Carrier M, Khorana AA, Zwicker JI, Noble S, Lee AY. Management of challenging cases of patients with cancer-associated thrombosis including recurrent thrombosis and bleeding: guidance from the SSC of the ISTH: a reply to a rebuttal. J Thromb Haemost. 2014 Jan; 12(1):116-7. PMID: 24406069.
    View in: PubMed
  29. Carrier M, Khorana AA, Moretto P, Le Gal G, Karp R, Zwicker JI. Lack of evidence to support thromboprophylaxis in hospitalized medical patients with cancer. Am J Med. 2014 Jan; 127(1):82-6.e1. PMID: 24384102.
    View in: PubMed
  30. Carrier M, Khorana AA, Zwicker J, Noble S, Lee AY. Management of challenging cases of patients with cancer-associated thrombosis including recurrent thrombosis and bleeding: guidance from the SSC of the ISTH. J Thromb Haemost. 2013 Sep; 11(9):1760-5. PMID: 23809334.
    View in: PubMed
  31. Zwicker JI, Liebman HA, Bauer KA, Caughey T, Campigotto F, Rosovsky R, Mantha S, Kessler CM, Eneman J, Raghavan V, Lenz HJ, Bullock A, Buchbinder E, Neuberg D, Furie B. Prediction and prevention of thromboembolic events with enoxaparin in cancer patients with elevated tissue factor-bearing microparticles: a randomized-controlled phase II trial (the Microtec study). Br J Haematol. 2013 Feb; 160(4):530-7. PMID: 23240761; PMCID: PMC3609903.
  32. Carrier M, Khorana AA, Zwicker JI, Lyman GH, Le Gal G, Lee AY. Venous thromboembolism in cancer clinical trials: recommendation for standardized reporting and analysis. J Thromb Haemost. 2012 Dec; 10(12):2599-601. PMID: 23362524.
    View in: PubMed
  33. Mantha S, Karp R, Raghavan V, Terrin N, Bauer KA, Zwicker JI. Assessing the risk of venous thromboembolic events in women taking progestin-only contraception: a meta-analysis. BMJ. 2012 Aug 07; 345:e4944. PMID: 22872710; PMCID: PMC3413580.
  34. Campigotto F, Neuberg D, Zwicker JI. Biased estimation of thrombosis rates in cancer studies using the method of Kaplan and Meier. J Thromb Haemost. 2012 Jul; 10(7):1449-51. PMID: 22554355; PMCID: PMC4528617.
  35. Khorana AA, Spyropoulos AC, Zwicker J, Lyman GH, Francis CW. Preventing VTE in Outpatients With Cancer. Chest. 2012 Jul; 142(1):265-266. PMID: 22796860; PMCID: PMC3418862.
  36. Luptakova K, Rosenblatt J, Glotzbecker B, Mills H, Stroopinsky D, Kufe T, Vasir B, Arnason J, Tzachanis D, Zwicker JI, Joyce RM, Levine JD, Anderson KC, Kufe D, Avigan D. Lenalidomide enhances anti-myeloma cellular immunity. Cancer Immunol Immunother. 2013 Jan; 62(1):39-49. PMID: 22733396.
    View in: PubMed
  37. Weitz IC, Razavi P, Rochanda L, Zwicker J, Furie B, Manly D, Mackman N, Green R, Liebman HA. Eculizumab therapy results in rapid and sustained decreases in markers of thrombin generation and inflammation in patients with PNH independent of its effects on hemolysis and microparticle formation. Thromb Res. 2012 Sep; 130(3):361-8. PMID: 22542362.
    View in: PubMed
  38. Campigotto F, Neuberg D, Zwicker JI. Accounting for death as a competing risk in cancer-associated thrombosis studies. Thromb Res. 2012 Apr; 129 Suppl 1:S85-7. PMID: 22682141.
    View in: PubMed
  39. Theisen-Toupal J, Rosenthal ES, Kelly E, Zwicker JI, Akuthota P, Roberts DH. Pulmonary zygomycosis in a non-neutropenic patient with myelodysplastic syndrome on lenalidomide. Respir Care. 2012 Jul; 57(7):1175-7. PMID: 22369887.
    View in: PubMed
  40. Zwicker JI, Lacroix R, Dignat-George F, Furie BC, Furie B. Measurement of platelet microparticles. Methods Mol Biol. 2012; 788:127-39. PMID: 22130705.
    View in: PubMed
  41. Zwicker JI, Trenor CC, Furie BC, Furie B. Tissue factor-bearing microparticles and thrombus formation. Arterioscler Thromb Vasc Biol. 2011 Apr; 31(4):728-33. PMID: 21252066.
    View in: PubMed
  42. Zwicker JI. Impedance-based flow cytometry for the measurement of microparticles. Semin Thromb Hemost. 2010 Nov; 36(8):819-23. PMID: 21049382.
    View in: PubMed
  43. Zwicker JI. Predictive value of tissue factor bearing microparticles in cancer associated thrombosis. Thromb Res. 2010 Apr; 125 Suppl 2:S89-91. PMID: 20434015.
    View in: PubMed
  44. Mantha S, Bauer KA, Zwicker JI. Low molecular weight heparin to achieve live birth following unexplained pregnancy loss: a systematic review. J Thromb Haemost. 2010 Feb; 8(2):263-8. PMID: 19912516.
    View in: PubMed
  45. Zwicker JI, Liebman HA, Neuberg D, Lacroix R, Bauer KA, Furie BC, Furie B. Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy. Clin Cancer Res. 2009 Nov 15; 15(22):6830-40. PMID: 19861441; PMCID: PMC2783253.
  46. Zwicker JI. Tissue factor-bearing microparticles and cancer. Semin Thromb Hemost. 2008 Mar; 34(2):195-8. PMID: 18645925.
    View in: PubMed
  47. Freedman RA, Bauer KA, Neuberg DS, Zwicker JI. Timing of postpartum enoxaparin administration and severe postpartum hemorrhage. Blood Coagul Fibrinolysis. 2008 Jan; 19(1):55-9. PMID: 18180616.
    View in: PubMed
  48. Zwicker JI, Furie BC, Furie B. Cancer-associated thrombosis. Crit Rev Oncol Hematol. 2007 May; 62(2):126-36. PMID: 17293122.
    View in: PubMed
  49. Zwicker JI, Peyvandi F, Palla R, Lombardi R, Canciani MT, Cairo A, Ardissino D, Bernardinelli L, Bauer KA, Lawler J, Mannucci P. The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size. Blood. 2006 Aug 15; 108(4):1280-3. PMID: 16684956; PMCID: PMC1895875.
  50. Zwicker JI, Uhl L, Huang WY, Shaz BH, Bauer KA. Thrombosis and ELISA optical density values in hospitalized patients with heparin-induced thrombocytopenia. J Thromb Haemost. 2004 Dec; 2(12):2133-7. PMID: 15613017.
    View in: PubMed
  51. Adams AE, Zwicker J, Curiel C, Kadin ME, Falchuk KR, Drews R, Kupper TS. Aggressive cutaneous T-cell lymphomas after TNFalpha blockade. J Am Acad Dermatol. 2004 Oct; 51(4):660-2. PMID: 15389210.
    View in: PubMed
  52. Näär AM, Beaurang PA, Robinson KM, Oliner JD, Avizonis D, Scheek S, Zwicker J, Kadonaga JT, Tjian R. Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro. Genes Dev. 1998 Oct 01; 12(19):3020-31. PMID: 9765204; PMCID: PMC317191.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.