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profileFrancis John Hornicek, M.D., PH.D.

TitleVisiting Professor of Orthopedic Surgery
InstitutionMassachusetts General Hospital
DepartmentOrthopedic Surgery
AddressMassachusetts General Hospital
Orthopedic Surgery GRB 604a
55 Fruit St
Boston MA 02114
Phone617/724-7626
Fax617/726-6823
vCardDownload vCard (login for email)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Shah AA, Paulino Pereira NR, Pedlow FX, Wain JC, Yoon SS, Hornicek FJ, Schwab JH. Modified En Bloc Spondylectomy for Tumors of the Thoracic and Lumbar Spine: Surgical Technique and Outcomes. J Bone Joint Surg Am. 2017 Sep 06; 99(17):1476-1484. PMID: 28872530.
    View in: PubMed
  2. Han C, Seebacher NA, Hornicek FJ, Kan Q, Duan Z. Regulation of microRNAs function by circular RNAs in human cancer. Oncotarget. 2017 Sep 08; 8(38):64622-64637. PMID: 28969099.
    View in: PubMed
  3. Arain A, Hornicek FJ, Schwab JH, Chebib I, Damron TA. Chordoma arising from benign multifocal notochordal tumors. Skeletal Radiol. 2017 Aug 03. PMID: 28776089.
    View in: PubMed
  4. Gao S, Shen J, Hornicek F, Duan Z. Three-dimensional (3D) culture in sarcoma research and the clinical significance. Biofabrication. 2017 Aug 03; 9(3):032003. PMID: 28707624.
    View in: PubMed
  5. Li X, Shen JK, Hornicek FJ, Xiao T, Duan Z. Noncoding RNA in drug resistant sarcoma. Oncotarget. 2017 07 06. PMID: 28706159.
    View in: PubMed
  6. Tang F, Choy E, Tu C, Hornicek F, Duan Z. Therapeutic applications of histone deacetylase inhibitors in sarcoma. Cancer Treat Rev. 2017 Sep; 59:33-45. PMID: 28732326.
    View in: PubMed
  7. Li X, Shen JK, Hornicek FJ, Xiao T, Duan Z. Noncoding RNA in drug resistant sarcoma. Oncotarget. 2017 Sep 15; 8(40):69086-69104. PMID: 28978183.
    View in: PubMed
  8. Schwab JH, Janssen SJ, Paulino Pereira NR, Chen YLE, Wain JC, DeLaney TF, Hornicek FJ. Quality of life after resection of a chordoma of the mobile spine. Bone Joint J. 2017 Jul; 99-B(7):979-986. PMID: 28663407.
    View in: PubMed
  9. Yanamadala V, Rozman PA, Kumar JI, Schwab JH, Lee SG, Hornicek FJ, Curry WT. Vascularized Fibular Strut Autografts in Spinal Reconstruction after Resection of Vertebral Chordoma or Chondrosarcoma: A Retrospective Series. Neurosurgery. 2017 Jul 01; 81(1):156-164. PMID: 28327915.
    View in: PubMed
  10. Chen H, Garbutt CC, Spentzos D, Choy E, Hornicek FJ, Duan Z. Expression and Therapeutic Potential of SOX9 in Chordoma. Clin Cancer Res. 2017 Sep 01; 23(17):5176-5186. PMID: 28606919.
    View in: PubMed
  11. Knowlton SE, Zafonte R, O'Connor KC, Schwab J, Hornicek F. Characteristics and functional outcomes of chordoma patients admitted for inpatient rehabilitation. Disabil Rehabil. 2017 Jun 07; 1-6. PMID: 28589739.
    View in: PubMed
  12. Liu P, Garbutt C, Hornicek FJ, Liu F, Duan Z. Aberration of p73 Promoter Methylation in Chondrosarcoma. Anticancer Res. 2017 06; 37(6):2939-2945. PMID: 28551631.
    View in: PubMed
  13. Stacchiotti S, Gronchi A, Fossati P, Akiyama T, Alapetite C, Baumann M, Blay JY, Bolle S, Boriani S, Bruzzi P, Capanna R, Caraceni A, Casadei R, Colia V, Debus J, Delaney T, Desai A, Dileo P, Dijkstra S, Doglietto F, Flanagan A, Froelich S, Gardner PA, Gelderblom H, Gokaslan ZL, Haas R, Heery C, Hindi N, Hohenberger P, Hornicek F, Imai R, Jeys L, Jones RL, Kasper B, Kawai A, Krengli M, Leithner A, Logowska I, Martin Broto J, Mazzatenta D, Morosi C, Nicolai P, Norum OJ, Patel S, Penel N, Picci P, Pilotti S, Radaelli S, Ricchini F, Rutkowski P, Scheipl S, Sen C, Tamborini E, Thornton KA, Timmermann B, Torri V, Tunn PU, Uhl M, Yamada Y, Weber DC, Vanel D, Varga PP, Vleggeert-Lankamp CLA, Casali PG, Sommer J. Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group. Ann Oncol. 2017 Jun 01; 28(6):1230-1242. PMID: 28184416.
    View in: PubMed
  14. Pretz JL, Barysauskas CM, George S, Hornick JL, Raut CP, Chen YE, Marcus KJ, Choy E, Hornicek F, Ready JE, DeLaney TF, Baldini EH. Localized Adult Ewing Sarcoma: Favorable Outcomes with Alternating Vincristine, Doxorubicin, Cyclophosphamide, and Ifosfamide, Etoposide (VDC/IE)-Based Multimodality Therapy. Oncologist. 2017 May 26. PMID: 28550026.
    View in: PubMed
  15. Hill KE, Kelly AD, Kuijjer ML, Barry W, Rattani A, Garbutt CC, Kissick H, Janeway K, Perez-Atayde A, Goldsmith J, Gebhardt MC, Arredouani MS, Cote G, Hornicek F, Choy E, Duan Z, Quackenbush J, Haibe-Kains B, Spentzos D. An imprinted non-coding genomic cluster at 14q32 defines clinically relevant molecular subtypes in osteosarcoma across multiple independent datasets. J Hematol Oncol. 2017 May 15; 10(1):107. PMID: 28506242.
    View in: PubMed
  16. Min L, Choy E, Tu C, Hornicek F, Duan Z. Application of metabolomics in sarcoma: From biomarkers to therapeutic targets. Crit Rev Oncol Hematol. 2017 Aug; 116:1-10. PMID: 28693790.
    View in: PubMed
  17. Liu P, Shen JK, Hornicek FJ, Liu F, Duan Z. Wnt inhibitory factor 1 (WIF1) methylation and its association with clinical prognosis in patients with chondrosarcoma. Sci Rep. 2017 May 08; 7(1):1580. PMID: 28484252.
    View in: PubMed
  18. Liao Y, Chen L, Feng Y, Shen J, Gao Y, Cote G, Choy E, Harmon D, Mankin H, Hornicek F, Duan Z. Targeting programmed cell death ligand 1 by CRISPR/Cas9 in osteosarcoma cells. Oncotarget. 2017 May 02; 8(18):30276-30287. PMID: 28415820.
    View in: PubMed
  19. Knowlton SE, Goldstein R, O'Connor KC, Schwab J, Hornicek F, Zafonte R. Variables affecting functional improvement in chordoma patients admitted to an inpatient rehabilitation facility: A retrospective review. J Spinal Cord Med. 2017 May 02; 1-6. PMID: 28464722.
    View in: PubMed
  20. Henderson ER, Keeney BJ, Pala E, Funovics PT, Eward WC, Groundland JS, Ehrlichman LK, Puchner SS, Brigman BE, Ready JE, Temple HT, Ruggieri P, Windhager R, Letson GD, Hornicek FJ. The stability of the hip after the use of a proximal femoral endoprosthesis for oncological indications: analysis of variables relating to the patient and the surgical technique. Bone Joint J. 2017 Apr; 99-B(4):531-537. PMID: 28385944.
    View in: PubMed
  21. Min L, Garbutt C, Tu C, Hornicek F, Duan Z. Potentials of Long Noncoding RNAs (LncRNAs) in Sarcoma: From Biomarkers to Therapeutic Targets. Int J Mol Sci. 2017 Mar 29; 18(4). PMID: 28353666.
    View in: PubMed
  22. Liao Y, Sassi S, Halvorsen S, Feng Y, Shen J, Gao Y, Cote G, Choy E, Harmon D, Mankin H, Hornicek F, Duan Z. Androgen receptor is a potential novel prognostic marker and oncogenic target in osteosarcoma with dependence on CDK11. Sci Rep. 2017 Mar 06; 7:43941. PMID: 28262798.
    View in: PubMed
  23. van Wulfften Palthe OD, Houdek MT, Rose PS, Yaszemski MJ, Sim FH, Boland PJ, Healey JH, Hornicek FJ, Schwab JH. How Does the Level of Nerve Root Resection in En Bloc Sacrectomy Influence Patient-Reported Outcomes? Clin Orthop Relat Res. 2017 Mar; 475(3):607-616. PMID: 26992721.
    View in: PubMed
  24. Gao Y, Shen J, Choy E, Mankin H, Hornicek F, Duan Z. Inhibition of CDK4 sensitizes multidrug resistant ovarian cancer cells to paclitaxel by increasing apoptosiss. Cell Oncol (Dordr). 2017 Jun; 40(3):209-218. PMID: 28243976.
    View in: PubMed
  25. Paulino Pereira NR, Janssen SJ, Raskin KA, Hornicek FJ, Ferrone ML, Shin JH, Bramer JAM, van Dijk CN, Schwab JH. Most efficient questionnaires to measure quality of life, physical function, and pain in patients with metastatic spine disease: a cross-sectional prospective survey study. Spine J. 2017 Jul; 17(7):953-961. PMID: 28242336.
    View in: PubMed
  26. Min L, Choy E, Pollock RE, Tu C, Hornicek F, Duan Z. Autophagy as a potential target for sarcoma treatment. Biochim Biophys Acta. 2017 Aug; 1868(1):40-50. PMID: 28242349.
    View in: PubMed
  27. Lin M, Gao Y, Diefenbach TJ, Shen JK, Hornicek FJ, Park YI, Xu F, Lu TJ, Amiji M, Duan Z. Facial Layer-by-Layer Engineering of Upconversion Nanoparticles for Gene Delivery: Near-Infrared-Initiated Fluorescence Resonance Energy Transfer Tracking and Overcoming Drug Resistance in Ovarian Cancer. ACS Appl Mater Interfaces. 2017 Mar 08; 9(9):7941-7949. PMID: 28177223.
    View in: PubMed
  28. Biermann JS, Chow W, Reed DR, Lucas D, Adkins DR, Agulnik M, Benjamin RS, Brigman B, Budd GT, Curry WT, Didwania A, Fabbri N, Hornicek FJ, Kuechle JB, Lindskog D, Mayerson J, McGarry SV, Million L, Morris CD, Movva S, O'Donnell RJ, Randall RL, Rose P, Santana VM, Satcher RL, Schwartz H, Siegel HJ, Thornton K, Villalobos V, Bergman MA, Scavone JL. NCCN Guidelines Insights: Bone Cancer, Version 2.2017. J Natl Compr Canc Netw. 2017 Feb; 15(2):155-167. PMID: 28188186.
    View in: PubMed
  29. Sebro R, DeLaney TF, Hornicek F, Schwab J, Choy E, Nielsen GP, Rosenthal DI. Frequency and Risk Factors for Additional Lesions in the Axial Spine in Subjects With Chordoma: Indications for Screening. Spine (Phila Pa 1976). 2017 Jan 01; 42(1):E37-E40. PMID: 27254658.
    View in: PubMed
  30. Liu T, Li Z, Zhang Q, De Amorim Bernstein K, Lozano-Calderon S, Choy E, Hornicek FJ, Duan Z. Targeting ABCB1 (MDR1) in multi-drug resistant osteosarcoma cells using the CRISPR-Cas9 system to reverse drug resistance. Oncotarget. 2016 Dec 13; 7(50):83502-83513. PMID: 27835872.
    View in: PubMed
  31. Han C, Shen JK, Hornicek FJ, Kan Q, Duan Z. Regulation of microRNA-1 (miR-1) expression in human cancer. Biochim Biophys Acta. 2017 02; 1860(2):227-232. PMID: 27923712.
    View in: PubMed
  32. Nota SP, Russchen MJ, Raskin KA, Mankin HJ, Hornicek FJ, Schwab JH. Functional and oncological outcome after surgical resection of the scapula and clavicle for primary chondrosarcoma. Musculoskelet Surg. 2017 Apr; 101(1):67-73. PMID: 27900545.
    View in: PubMed
  33. Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK. Solid stress and elastic energy as measures of tumour mechanopathology. Nat Biomed Eng. 2016; 1. PMID: 28966873.
    View in: PubMed
  34. Paulino Pereira NR, Langerhuizen DW, Janssen SJ, Hornicek FJ, Ferrone ML, Harris MB, Schwab JH. Are perioperative allogeneic blood transfusions associated with 90-days infection after operative treatment for bone metastases? J Surg Oncol. 2016 Dec; 114(8):997-1003. PMID: 27859275.
    View in: PubMed
  35. van Wulfften Palthe ODR, Janssen SJ, Wunder JS, Ferguson PC, Wei G, Rose PS, Yaszemski MJ, Sim FH, Boland PJ, Healey JH, Hornicek FJ, Schwab JH. What questionnaires to use when measuring quality of life in sacral tumor patients: the updated sacral tumor survey. Spine J. 2017 May; 17(5):636-644. PMID: 27856381.
    View in: PubMed
  36. Paulino Pereira NR, Janssen SJ, van Dijk E, Harris MB, Hornicek FJ, Ferrone ML, Schwab JH. Development of a Prognostic Survival Algorithm for Patients with Metastatic Spine Disease. J Bone Joint Surg Am. 2016 Nov 02; 98(21):1767-1776. PMID: 27807108.
    View in: PubMed
  37. De Amorim Bernstein K, Liebsch N, Chen YL, Niemierko A, Schwab JH, Raskin K, Lozano-Calderon SA, Cote G, Harmon DC, Choy E, Haynes A, Mullen J, Hornicek FJ, DeLaney TF. Clinical outcomes for patients after surgery and radiation therapy for mesenchymal chondrosarcomas. J Surg Oncol. 2016 Dec; 114(8):982-986. PMID: 27790706.
    View in: PubMed
  38. Duan Z, Gao Y, Shen J, Choy E, Cote G, Harmon D, Bernstein K, Lozano-Calderon S, Mankin H, Hornicek FJ. miR-15b modulates multidrug resistance in human osteosarcoma in vitro and in vivo. Mol Oncol. 2017 Feb; 11(2):151-166. PMID: 28145098.
    View in: PubMed
  39. van der Vliet QM, Paulino Pereira NR, Janssen SJ, Hornicek FJ, Ferrone ML, Bramer JA, van Dijk CN, Schwab JH. What Factors are Associated With Quality Of Life, Pain Interference, Anxiety, and Depression in Patients With Metastatic Bone Disease? Clin Orthop Relat Res. 2017 Feb; 475(2):498-507. PMID: 27752988.
    View in: PubMed
  40. Kabolizadeh P, Chen YL, Liebsch N, Hornicek FJ, Schwab JH, Choy E, Rosenthal DI, Niemierko A, DeLaney TF. Updated Outcome and Analysis of Tumor Response in Mobile Spine and Sacral Chordoma Treated With Definitive High-Dose Photon/Proton Radiation Therapy. Int J Radiat Oncol Biol Phys. 2017 Feb 01; 97(2):254-262. PMID: 27986348.
    View in: PubMed
  41. Ren F, Shen J, Shi H, Hornicek FJ, Kan Q, Duan Z. Novel mechanisms and approaches to overcome multidrug resistance in the treatment of ovarian cancer. Biochim Biophys Acta. 2016 12; 1866(2):266-275. PMID: 27717733.
    View in: PubMed
  42. Liu P, Shen JK, Xu J, Trahan CA, Hornicek FJ, Duan Z. Aberrant DNA methylations in chondrosarcoma. Epigenomics. 2016 Nov; 8(11):1519-1525. PMID: 27686001.
    View in: PubMed
  43. Janssen SJ, van Rein EA, Paulino Pereira NR, Raskin KA, Ferrone ML, Hornicek FJ, Lozano-Calderon SA, Schwab JH. The Discrepancy between Patient and Clinician Reported Function in Extremity Bone Metastases. Sarcoma. 2016; 2016:1014248. PMID: 27725792.
    View in: PubMed
  44. Sebro R, DeLaney T, Hornicek F, Schwab J, Choy E, Nielsen GP, Rosenthal DI. Differences in sex distribution, anatomic location and MR imaging appearance of pediatric compared to adult chordomas. BMC Med Imaging. 2016 Sep 08; 16(1):53. PMID: 27609115; PMCID: PMC5016865.
  45. Min L, Shen J, Tu C, Hornicek F, Duan Z. The roles and implications of exosomes in sarcoma. Cancer Metastasis Rev. 2016 09; 35(3):377-90. PMID: 27342745; PMCID: PMC5037004 [Available on 09/01/17].
  46. Choy E, Hornicek FJ, Chen YL, Rosenthal DI, Kerr DA. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 26-2016. A 28-Year-Old Woman with Back Pain and a Lesion in the Lumbar Spine. N Engl J Med. 2016 Aug 25; 375(8):779-88. PMID: 27557305.
    View in: PubMed
  47. Janssen SJ, Paulino Pereira NR, Raskin KA, Ferrone ML, Hornicek FJ, van Dijk CN, Lozano-Calderón SA, Schwab JH. A comparison of questionnaires for assessing physical function in patients with lower extremity bone metastases. J Surg Oncol. 2016 Nov; 114(6):691-696. PMID: 27511611.
    View in: PubMed
  48. Peacock ZS, Schwab JH, Faquin WC, Hornicek FJ, Benita Y, Ebb DH, Kaban LB. Genetic Analysis of Giant Cell Lesions of the Maxillofacial and Axial/Appendicular Skeletons. J Oral Maxillofac Surg. 2017 Feb; 75(2):298-308. PMID: 27546031.
    View in: PubMed
  49. Ahmad R, Jacobson A, Hornicek F, Haynes AB, Choy E, Cote G, Nielsen GP, Chen YL, DeLaney TF, Mullen JT. The Width of the Surgical Margin Does Not Influence Outcomes in Extremity and Truncal Soft Tissue Sarcoma Treated With Radiotherapy. Oncologist. 2016 Oct; 21(10):1269-1276. PMID: 27440063.
    View in: PubMed
  50. Janssen SJ, Teunis T, Hornicek FJ, van Dijk CN, Bramer JA, Schwab JH. Outcome after fixation of metastatic proximal femoral fractures: A systematic review of 40 studies. J Surg Oncol. 2016 Sep; 114(4):507-19. PMID: 27374478.
    View in: PubMed
  51. Janssen SJ, Kortlever JT, Ready JE, Raskin KA, Ferrone ML, Hornicek FJ, Lozano-Calderon SA, Schwab JH. Complications After Surgical Management of Proximal Femoral Metastasis: A Retrospective Study of 417 Patients. J Am Acad Orthop Surg. 2016 Jul; 24(7):483-94. PMID: 27227983.
    View in: PubMed
  52. Zhou Y, Shen JK, Hornicek FJ, Kan Q, Duan Z. The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer. Oncotarget. 2016 Jun 28; 7(26):40846-40859. PMID: 27049727.
    View in: PubMed
  53. Sun R, Shen J, Gao Y, Zhou Y, Yu Z, Hornicek F, Kan Q, Duan Z. Overexpression of EZH2 is associated with the poor prognosis in osteosarcoma and function analysis indicates a therapeutic potential. Oncotarget. 2016 Jun 21; 7(25):38333-38346. PMID: 27223261.
    View in: PubMed
  54. Liao Y, Feng Y, Shen J, Hornicek FJ, Duan Z. The roles and therapeutic potential of cyclin-dependent kinases (CDKs) in sarcoma. Cancer Metastasis Rev. 2016 06; 35(2):151-63. PMID: 26669603.
    View in: PubMed
  55. Liu X, Gao Y, Shen J, Yang W, Choy E, Mankin H, Hornicek FJ, Duan Z. Cyclin-Dependent Kinase 11 (CDK11) Is Required for Ovarian Cancer Cell Growth In Vitro and In Vivo, and Its Inhibition Causes Apoptosis and Sensitizes Cells to Paclitaxel. Mol Cancer Ther. 2016 Jul; 15(7):1691-701. PMID: 27207777; PMCID: PMC4936930 [Available on 07/01/17].
  56. Chebib I, Rosenberg AE, Fletcher CD, Rosenthal DI, Hornicek FJ, Nielsen GP. Primary intra-articular sarcoma: a clinicopathological study of 15 cases. Histopathology. 2016 Oct; 69(4):614-23. PMID: 27028835.
    View in: PubMed
  57. Langerhuizen DW, Janssen SJ, van der Vliet QM, Raskin KA, Ferrone ML, Hornicek FJ, Schwab JH, Lozano-Calderón SA. Metastasectomy, intralesional resection, or stabilization only in the treatment of bone metastases from renal cell carcinoma. J Surg Oncol. 2016 Aug; 114(2):237-45. PMID: 27156495.
    View in: PubMed
  58. Gao Y, Shen JK, Choy E, Zhang Z, Mankin HJ, Hornicek FJ, Duan Z. Pharmacokinetics and tolerability of NSC23925b, a novel P-glycoprotein inhibitor: preclinical study in mice and rats. Sci Rep. 2016 May 09; 6:25659. PMID: 27157103; PMCID: PMC4860631.
  59. Shen JK, Cote GM, Gao Y, Choy E, Mankin HJ, Hornicek FJ, Duan Z. Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro. Sci Rep. 2016 04 29; 6:25239. PMID: 27125524; PMCID: PMC4850444.
  60. Midkiff KD, Andrews EB, Gilsenan AW, Deapen DM, Harris DH, Schymura MJ, Hornicek FJ. The experience of accommodating privacy restrictions during implementation of a large-scale surveillance study of an osteoporosis medication. Pharmacoepidemiol Drug Saf. 2016 Aug; 25(8):960-8. PMID: 27091234.
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  61. Paulino Pereira NR, Beks RB, Janssen SJ, Harris MB, Hornicek FJ, Ferrone ML, Schwab JH. Are allogeneic blood transfusions associated with decreased survival after surgical treatment for spinal metastases? Spine J. 2016 Aug; 16(8):951-61. PMID: 27033311.
    View in: PubMed
  62. Phukan R, Herzog T, Boland PJ, Healey J, Rose P, Sim FH, Yazsemski M, Hess K, Osler P, DeLaney TF, Chen YL, Hornicek F, Schwab J. How Does the Level of Sacral Resection for Primary Malignant Bone Tumors Affect Physical and Mental Health, Pain, Mobility, Incontinence, and Sexual Function? Clin Orthop Relat Res. 2016 Mar; 474(3):687-96. PMID: 26013155; PMCID: PMC4746195 [Available on 03/01/17].
  63. Gao Y, Liao Y, Shen JK, Feng Y, Choy E, Cote G, Harmon D, Mankin HJ, Hornicek FJ, Duan Z. Evaluation of P-glycoprotein (Pgp) expression in human osteosarcoma by high-throughput tissue microarray. J Orthop Res. 2016 Sep; 34(9):1606-12. PMID: 26790551.
    View in: PubMed
  64. Wang H, Jacobson A, Harmon DC, Choy E, Hornicek FJ, Raskin KA, Chebib IA, DeLaney TF, Chen YL. Prognostic factors in alveolar soft part sarcoma: A SEER analysis. J Surg Oncol. 2016 Apr; 113(5):581-6. PMID: 26804150.
    View in: PubMed
  65. Liu T, Shen JK, Li Z, Choy E, Hornicek FJ, Duan Z. Development and potential applications of CRISPR-Cas9 genome editing technology in sarcoma. Cancer Lett. 2016 Apr 01; 373(1):109-118. PMID: 26806808; PMCID: PMC4772675 [Available on 04/01/17].
  66. Ye S, Zhang J, Shen J, Gao Y, Li Y, Choy E, Cote G, Harmon D, Mankin H, Gray NS, Hornicek FJ, Duan Z. NVP-TAE684 reverses multidrug resistance (MDR) in human osteosarcoma by inhibiting P-glycoprotein (PGP1) function. Br J Pharmacol. 2016 Feb; 173(3):613-26. PMID: 26603906; PMCID: PMC4728419 [Available on 02/01/17].
  67. Wojcik J, Rosenberg AE, Bredella MA, Choy E, Hornicek FJ, Nielsen GP, Deshpande V. Denosumab-treated Giant Cell Tumor of Bone Exhibits Morphologic Overlap With Malignant Giant Cell Tumor of Bone. Am J Surg Pathol. 2016 Jan; 40(1):72-80. PMID: 26414220.
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  68. Li J, Shen J, Wang K, Hornicek F, Duan Z. The Roles of Sox Family Genes in Sarcoma. Curr Drug Targets. 2016; 17(15):1761-1772. PMID: 27138764.
    View in: PubMed
  69. Liao Y, Feng Y, Shen J, Gao Y, Cote G, Choy E, Harmon D, Mankin H, Hornicek F, Duan Z. Clinical and biological significance of PIM1 kinase in osteosarcoma. J Orthop Res. 2016 Jul; 34(7):1185-94. PMID: 26687194.
    View in: PubMed
  70. Young VA, Curtis KM, Temple HT, Eismont FJ, DeLaney TF, Hornicek FJ. Characteristics and Patterns of Metastatic Disease from Chordoma. Sarcoma. 2015; 2015:517657. PMID: 26843835; PMCID: PMC4710904.
  71. Ye S, Shen J, Choy E, Yang C, Mankin H, Hornicek F, Duan Z. p53 overexpression increases chemosensitivity in multidrug-resistant osteosarcoma cell lines. Cancer Chemother Pharmacol. 2016 Feb; 77(2):349-56. PMID: 26698867; PMCID: PMC4749432 [Available on 02/01/17].
  72. Lozano Calderón SA, Raskin KA, Hornicek F, Schwab JH. What's New in Orthopaedic Oncology. J Bone Joint Surg Am. 2015 Dec 16; 97(24):2061-7. PMID: 26677240.
    View in: PubMed
  73. Schoenfeld AJ, Wang X, Wang Y, Hornicek FJ, Nielsen GP, Duan Z, Ferrone S, Schwab JH. CSPG4 as a prognostic biomarker in chordoma. Spine J. 2016 Jun; 16(6):722-7. PMID: 26689475.
    View in: PubMed
  74. Chen H, Shen J, Choy E, Hornicek FJ, Duan Z. Targeting protein kinases to reverse multidrug resistance in sarcoma. Cancer Treat Rev. 2016 Feb; 43:8-18. PMID: 26827688; PMCID: PMC4735639 [Available on 02/01/17].
  75. Sun X, Hornicek F, Schwab JH. Chordoma: an update on the pathophysiology and molecular mechanisms. Curr Rev Musculoskelet Med. 2015 Dec; 8(4):344-52. PMID: 26493697; PMCID: PMC4630230.
  76. Janssen SJ, van Dijke M, Lozano-Calderón SA, Ready JE, Raskin KA, Ferrone ML, Hornicek FJ, Schwab JH. Complications after surgery for metastatic humeral lesions. J Shoulder Elbow Surg. 2016 Feb; 25(2):207-15. PMID: 26547526.
    View in: PubMed
  77. Karim SM, Colman MC, Cipriani NA, Nielsen GP, Schwab JH, Hornicek FJ. Surgical management of Gorham-Stout disease of the pelvis refractory to medical and radiation therapy. Am J Orthop (Belle Mead NJ). 2015 Nov; 44(11):E473-7. PMID: 26566566.
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  78. Sun R, Shen JK, Choy E, Yu Z, Hornicek FJ, Duan Z. The emerging roles and therapeutic potential of microRNAs (miRs) in liposarcoma. Discov Med. 2015 Nov; 20(111):311-24. PMID: 26645903.
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  79. Lin M, Gao Y, Hornicek F, Xu F, Lu TJ, Amiji M, Duan Z. Near-infrared light activated delivery platform for cancer therapy. Adv Colloid Interface Sci. 2015 Dec; 226(Pt B):123-37. PMID: 26520243.
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  80. Al-Rashid M, Ramkumar DB, Raskin K, Schwab J, Hornicek FJ, Lozano-Calderón SA. Paget Disease of Bone. Orthop Clin North Am. 2015 Oct; 46(4):577-85. PMID: 26410646.
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  81. Osler P, Bredella MA, Hess KA, Janssen SJ, Park CJ, Chen YL, DeLaney TF, Hornicek FJ, Schwab JH. Sacral Insufficiency Fractures are Common After High-dose Radiation for Sacral Chordomas Treated With or Without Surgery. Clin Orthop Relat Res. 2016 Mar; 474(3):766-72. PMID: 26400251; PMCID: PMC4746193 [Available on 03/01/17].
  82. Colman MW, Hornicek FJ, Schwab JH. Spinal Cord Blood Supply and Its Surgical Implications. J Am Acad Orthop Surg. 2015 Oct; 23(10):581-91. PMID: 26377671.
    View in: PubMed
  83. Rotondo RL, Folkert W, Liebsch NJ, Chen YL, Pedlow FX, Schwab JH, Rosenberg AE, Nielsen GP, Szymonifka J, Ferreira AE, Hornicek FJ, DeLaney TF. High-dose proton-based radiation therapy in the management of spine chordomas: outcomes and clinicopathological prognostic factors. J Neurosurg Spine. 2015 Dec; 23(6):788-97. PMID: 26340383.
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  84. Sun X, Guo W, Shen JK, Mankin HJ, Hornicek FJ, Duan Z. Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. Sarcoma. 2015; 2015:232010. PMID: 26420980; PMCID: PMC4569767.
  85. Janssen SJ, Teunis T, van Dijk E, Ferrone ML, Shin JH, Hornicek F, Schwab JH. Validation of the Spine Oncology Study Group-Outcomes Questionnaire to assess quality of life in patients with metastatic spine disease. Spine J. 2017 Jun; 17(6):768-776. PMID: 26254565.
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  86. Janssen SJ, van der Heijden AS, van Dijke M, Ready JE, Raskin KA, Ferrone ML, Hornicek FJ, Schwab JH. 2015 Marshall Urist Young Investigator Award: Prognostication in Patients With Long Bone Metastases: Does a Boosting Algorithm Improve Survival Estimates? Clin Orthop Relat Res. 2015 Oct; 473(10):3112-21. PMID: 26155769; PMCID: PMC4562931 [Available on 10/01/16].
  87. Gao Y, Feng Y, Shen JK, Lin M, Choy E, Cote GM, Harmon DC, Mankin HJ, Hornicek FJ, Duan Z. CD44 is a direct target of miR-199a-3p and contributes to aggressive progression in osteosarcoma. Sci Rep. 2015 Jun 16; 5:11365. PMID: 26079799; PMCID: PMC4468826.
  88. Feng Y, Shen J, Gao Y, Liao Y, Cote G, Choy E, Chebib I, Mankin H, Hornicek F, Duan Z. Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma. Oncotarget. 2015 May 10; 6(13):11139-49. PMID: 25871477; PMCID: PMC4484445.
  89. Yang X, Shen J, Gao Y, Feng Y, Guan Y, Zhang Z, Mankin H, Hornicek FJ, Duan Z. Nsc23925 prevents the development of paclitaxel resistance by inhibiting the introduction of P-glycoprotein and enhancing apoptosis. Int J Cancer. 2015 Oct 15; 137(8):2029-39. PMID: 25904021; PMCID: PMC4529776 [Available on 10/15/16].
  90. Osaka E, Kelly AD, Spentzos D, Choy E, Yang X, Shen JK, Yang P, Mankin HJ, Hornicek FJ, Duan Z. MicroRNA-155 expression is independently predictive of outcome in chordoma. Oncotarget. 2015 Apr 20; 6(11):9125-39. PMID: 25823817; PMCID: PMC4496207.
  91. Gao Y, Foster R, Yang X, Feng Y, Shen JK, Mankin HJ, Hornicek FJ, Amiji MM, Duan Z. Up-regulation of CD44 in the development of metastasis, recurrence and drug resistance of ovarian cancer. Oncotarget. 2015 Apr 20; 6(11):9313-26. PMID: 25823654; PMCID: PMC4496219.
  92. Zhang L, Lyer AK, Yang X, Kobayashi E, Guo Y, Mankin H, Hornicek FJ, Amiji MM, Duan Z. Polymeric nanoparticle-based delivery of microRNA-199a-3p inhibits proliferation and growth of osteosarcoma cells. Int J Nanomedicine. 2015; 10:2913-24. PMID: 25931818; PMCID: PMC4404938.
  93. Colman MW, Karim SM, Lozano-Calderon SA, Pedlow FX, Raskin KA, Hornicek FJ, Schwab JH. Quality of life after en bloc resection of tumors in the mobile spine. Spine J. 2015 Aug 01; 15(8):1728-37. PMID: 25862510.
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  94. Colman MW, Karim SM, Hirsch JA, Yoo AJ, Schwab JH, Hornicek FJ, Raskin KA. Percutaneous Acetabuloplasty Compared With Open Reconstruction for Extensive Periacetabular Carcinoma Metastases. J Arthroplasty. 2015 Sep; 30(9):1586-91. PMID: 26115981.
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  95. Yang X, Iyer AK, Singh A, Choy E, Hornicek FJ, Amiji MM, Duan Z. MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer. Sci Rep. 2015 Feb 17; 5:8509. PMID: 25687880; PMCID: PMC4330541.
  96. Yang X, Feng Y, Gao Y, Shen J, Choy E, Cote G, Harmon D, Zhang Z, Mankin H, Hornicek FJ, Duan Z. NSC23925 prevents the emergence of multidrug resistance in ovarian cancer in vitro and in vivo. Gynecol Oncol. 2015 Apr; 137(1):134-42. PMID: 25677062.
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  97. Janssen SJ, Braun Y, Ready JE, Raskin KA, Ferrone ML, Hornicek FJ, Schwab JH. Are Allogeneic Blood Transfusions Associated With Decreased Survival After Surgery for Long-bone Metastatic Fractures? Clin Orthop Relat Res. 2015 Jul; 473(7):2343-51. PMID: 25637400; PMCID: PMC4457741.
  98. Chebib I, Hornicek FJ, Nielsen GP, Deshpande V. Cytomorphologic features that distinguish schwannoma from other low-grade spindle cell lesions. Cancer Cytopathol. 2015 Mar; 123(3):171-9. PMID: 25641870.
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  99. Gao Y, Shen JK, Milane L, Hornicek FJ, Amiji MM, Duan Z. Targeted cancer therapy; nanotechnology approaches for overcoming drug resistance. Curr Med Chem. 2015; 22(11):1335-47. PMID: 25666804.
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  100. Choy E, Flamand Y, Balasubramanian S, Butrynski JE, Harmon DC, George S, Cote GM, Wagner AJ, Morgan JA, Sirisawad M, Mani C, Hornicek FJ, Duan Z, Demetri GD. Phase 1 study of oral abexinostat, a histone deacetylase inhibitor, in combination with doxorubicin in patients with metastatic sarcoma. Cancer. 2015 Apr 15; 121(8):1223-30. PMID: 25536954; PMCID: PMC4393337 [Available on 04/15/16].
  101. Yang X, Iyer AK, Singh A, Milane L, Choy E, Hornicek FJ, Amiji MM, Duan Z. Cluster of Differentiation 44 Targeted Hyaluronic Acid Based Nanoparticles for MDR1 siRNA Delivery to Overcome Drug Resistance in Ovarian Cancer. Pharm Res. 2015 Jun; 32(6):2097-109. PMID: 25515492; PMCID: PMC4425596.
  102. Schwab JH, Lozano-Calderon SA, Mankin HJ, Raskin KA, Hornicek FJ. What's new in primary bone tumors. J Bone Joint Surg Am. 2014 Dec 17; 96(24):2099-104. PMID: 25520345.
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  103. Cheney MD, Chen YL, Lim R, Winrich BK, Grosu AL, Trofimov AV, Depauw N, Shih HA, Schwab JH, Hornicek FJ, DeLaney TF. [18F]-Fluoromisonidazole positron emission tomography/computed tomography visualization of tumor hypoxia in patients with chordoma of the mobile and sacrococcygeal spine. Int J Radiat Oncol Biol Phys. 2014 Dec 01; 90(5):1030-6. PMID: 25539367; PMCID: PMC4280072.
  104. Janssen SJ, Teunis T, Hornicek FJ, Bramer JA, Schwab JH. Outcome of operative treatment of metastatic fractures of the humerus: a systematic review of twenty three clinical studies. Int Orthop. 2015 Apr; 39(4):735-46. PMID: 25398471.
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  105. Henderson ER, O'Connor MI, Ruggieri P, Windhager R, Funovics PT, Gibbons CL, Guo W, Hornicek FJ, Temple HT, Letson GD. Classification of failure of limb salvage after reconstructive surgery for bone tumours : a modified system Including biological and expandable reconstructions. Bone Joint J. 2014 Nov; 96-B(11):1436-40. PMID: 25371453.
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  106. Wojcik JB, Bellizzi AM, Dal Cin P, Bredella MA, Fletcher CD, Hornicek FJ, Deshpande V, Hornick JL, Nielsen GP. Primary sclerosing epithelioid fibrosarcoma of bone: analysis of a series. Am J Surg Pathol. 2014 Nov; 38(11):1538-44. PMID: 24921641.
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  107. Morii T, Ohtsuka K, Ohnishi H, Mochizuki K, Yoshiyama A, Aoyagi T, Hornicek FJ, Ichimura S. BH3 mimetics inhibit growth of chondrosarcoma--a novel targeted-therapy for candidate models. Anticancer Res. 2014 Nov; 34(11):6423-30. PMID: 25368242.
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  108. Riggi N, Knoechel B, Gillespie SM, Rheinbay E, Boulay G, Suvà ML, Rossetti NE, Boonseng WE, Oksuz O, Cook EB, Formey A, Patel A, Gymrek M, Thapar V, Deshpande V, Ting DT, Hornicek FJ, Nielsen GP, Stamenkovic I, Aryee MJ, Bernstein BE, Rivera MN. EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma. Cancer Cell. 2014 Nov 10; 26(5):668-681. PMID: 25453903; PMCID: PMC4492343.
  109. Feng Y, Sassi S, Shen JK, Yang X, Gao Y, Osaka E, Zhang J, Yang S, Yang C, Mankin HJ, Hornicek FJ, Duan Z. Targeting CDK11 in osteosarcoma cells using the CRISPR-Cas9 system. J Orthop Res. 2015 Feb; 33(2):199-207. PMID: 25348612; PMCID: PMC4304907.
  110. Karim SM, Colman MW, Lozano-Calderón SA, Raskin KA, Schwab JH, Hornicek FJ. What are the functional results and complications from allograft reconstruction after partial hemipelvectomy of the pubis? Clin Orthop Relat Res. 2015 Apr; 473(4):1442-8. PMID: 25337979; PMCID: PMC4353538.
  111. Duan Z, Zhang J, Ye S, Shen J, Choy E, Cote G, Harmon D, Mankin H, Hua Y, Zhang Y, Gray NS, Hornicek FJ. A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells. BMC Cancer. 2014 Sep 19; 14:681. PMID: 25236161; PMCID: PMC4177239.
  112. Pan E, Goldberg SI, Chen YL, Giraud C, Hornick JL, Nielsen GP, Hornicek FJ, Raut CP, DeLaney TF, Baldini EH. Role of post-operative radiation boost for soft tissue sarcomas with positive margins following pre-operative radiation and surgery. J Surg Oncol. 2014 Dec; 110(7):817-22. PMID: 25111884.
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  113. Shen JK, Cote GM, Choy E, Hornicek FJ, Duan Z. Targeting programmed cell death ligand 1 in osteosarcoma: an auto-commentary on therapeutic potential. Oncoimmunology. 2014; 3(8):e954467. PMID: 25610746.
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  114. Mullen JT, Hornicek FJ, Harmon DC, Raskin KA, Chen YL, Szymonifka J, Yeap BY, Choy E, DeLaney TF, Nielsen GP. Prognostic significance of treatment-induced pathologic necrosis in extremity and truncal soft tissue sarcoma after neoadjuvant chemoradiotherapy. Cancer. 2014 Dec 01; 120(23):3676-82. PMID: 25081640; PMCID: PMC4239184.
  115. Choy E, MacConaill LE, Cote GM, Le LP, Shen JK, Nielsen GP, Iafrate AJ, Garraway LA, Hornicek FJ, Duan Z. Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1. PLoS One. 2014; 9(7):e101283. PMID: 24983247; PMCID: PMC4077728.
  116. Lozano-Calderon SA, Colman MW, Raskin KA, Hornicek FJ, Gebhardt M. Use of bisphosphonates in orthopedic surgery: pearls and pitfalls. Orthop Clin North Am. 2014 Jul; 45(3):403-16. PMID: 24975766.
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  117. Yang X, Yang P, Shen J, Osaka E, Choy E, Cote G, Harmon D, Zhang Z, Mankin H, Hornicek FJ, Duan Z. Prevention of multidrug resistance (MDR) in osteosarcoma by NSC23925. Br J Cancer. 2014 Jun 10; 110(12):2896-904. PMID: 24853187; PMCID: PMC4056062.
  118. Osaka E, Yang X, Shen JK, Yang P, Feng Y, Mankin HJ, Hornicek FJ, Duan Z. MicroRNA-1 (miR-1) inhibits chordoma cell migration and invasion by targeting slug. J Orthop Res. 2014 Aug; 32(8):1075-82. PMID: 24760686; PMCID: PMC4123853.
  119. Shen JK, Cote GM, Choy E, Yang P, Harmon D, Schwab J, Nielsen GP, Chebib I, Ferrone S, Wang X, Wang Y, Mankin H, Hornicek FJ, Duan Z. Programmed cell death ligand 1 expression in osteosarcoma. Cancer Immunol Res. 2014 Jul; 2(7):690-698. PMID: 24866169; PMCID: PMC4082476.
  120. DeLaney TF, Liebsch NJ, Pedlow FX, Adams J, Weyman EA, Yeap BY, Depauw N, Nielsen GP, Harmon DC, Yoon SS, Chen YL, Schwab JH, Hornicek FJ. Long-term results of Phase II study of high dose photon/proton radiotherapy in the management of spine chordomas, chondrosarcomas, and other sarcomas. J Surg Oncol. 2014 Aug; 110(2):115-22. PMID: 24752878.
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  121. Guo S, Lopez-Marquez H, Fan KC, Choy E, Cote G, Harmon D, Nielsen GP, Yang C, Zhang C, Mankin H, Hornicek FJ, Borger DR, Duan Z. Synergistic effects of targeted PI3K signaling inhibition and chemotherapy in liposarcoma. PLoS One. 2014; 9(4):e93996. PMID: 24695632; PMCID: PMC3973642.
  122. Cipriani NA, Kurzawa P, Ahmad RA, Deshpande V, Hornicek FJ, Mullen JT, Nielsen GP. Prognostic value of myogenic differentiation in undifferentiated pleomorphic sarcomas of soft tissue. Hum Pathol. 2014 Jul; 45(7):1504-8. PMID: 24780826.
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  123. Gradl G, de Witte PB, Evans BT, Hornicek F, Raskin K, Ring D. Surgical site infection in orthopaedic oncology. J Bone Joint Surg Am. 2014 Feb 05; 96(3):223-30. PMID: 24500584.
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  124. Duan Z, Shen J, Yang X, Yang P, Osaka E, Choy E, Cote G, Harmon D, Zhang Y, Nielsen GP, Spentzos D, Mankin H, Hornicek F. Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma. J Orthop Res. 2014 May; 32(5):695-701. PMID: 24501096; PMCID: PMC4049352.
  125. Colman MW, Lozano-Calderon S, Raskin KA, Hornicek FJ, Gebhardt M. Non-neoplastic soft tissue masses that mimic sarcoma. Orthop Clin North Am. 2014 Apr; 45(2):245-55. PMID: 24684918.
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  126. Teunis T, Nota SP, Hornicek FJ, Schwab JH, Lozano-Calderón SA. Outcome after reconstruction of the proximal humerus for tumor resection: a systematic review. Clin Orthop Relat Res. 2014 Jul; 472(7):2245-53. PMID: 24469551; PMCID: PMC4048415.
  127. Cheney MD, Giraud C, Goldberg SI, Rosenthal DI, Hornicek FJ, Choy E, Mullen JT, Chen YL, Delaney TF. MRI surveillance following treatment of extremity soft tissue sarcoma. J Surg Oncol. 2014 May; 109(6):593-6. PMID: 24374823.
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  128. Schwab JH, Springfield DS, Raskin KA, Mankin HJ, Hornicek FJ. What's new in primary malignant musculoskeletal tumors. J Bone Joint Surg Am. 2013 Dec 18; 95(24):2240-6. PMID: 24352776.
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  129. Cipriani NA, Letovanec I, Hornicek FJ, Mullen JT, Duan Z, Borger DR, Nielsen GP. BRAF mutation in 'sarcomas': a possible method to detect de-differentiated melanomas. Histopathology. 2014 Apr; 64(5):639-46. PMID: 24117833.
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  130. Zhang L, Guo S, Schwab JH, Nielsen GP, Choy E, Ye S, Zhang Z, Mankin H, Hornicek FJ, Duan Z. Tissue microarray immunohistochemical detection of brachyury is not a prognostic indicator in chordoma. PLoS One. 2013; 8(9):e75851. PMID: 24086644; PMCID: PMC3781148.
  131. Boyaci B, Hornicek FJ, Nielsen GP, DeLaney TF, Pedlow FX, Mansfield FL, Carrier CS, Harms J, Schwab JH. Epithelioid hemangioma of the spine: a case series of six patients and review of the literature. Spine J. 2013 Dec; 13(12):e7-13. PMID: 24045160.
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  132. Jia B, Choy E, Cote G, Harmon D, Ye S, Kan Q, Mankin H, Hornicek F, Duan Z. Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells. Cancer Lett. 2014 Jan 01; 342(1):104-12. PMID: 24007862; PMCID: PMC4128631.
  133. Mullen JT, DeLaney TF, Rosenberg AE, Le L, Iafrate AJ, Kobayashi W, Szymonifka J, Yeap BY, Chen YL, Harmon DC, Choy E, Yoon SS, Raskin KA, Hornicek FJ, Nielsen GP. ß-Catenin mutation status and outcomes in sporadic desmoid tumors. Oncologist. 2013; 18(9):1043-9. PMID: 23960186; PMCID: PMC3780636.
  134. Kurzawa P, Kattapuram S, Hornicek FJ, Antonescu CR, Rosenberg AE, Nielsen GP. Primary myoepithelioma of bone: a report of 8 cases. Am J Surg Pathol. 2013 Jul; 37(7):960-8. PMID: 23681076.
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  135. Chen YL, Liebsch N, Kobayashi W, Goldberg S, Kirsch D, Calkins G, Childs S, Schwab J, Hornicek F, DeLaney T. Definitive high-dose photon/proton radiotherapy for unresected mobile spine and sacral chordomas. Spine (Phila Pa 1976). 2013 Jul 01; 38(15):E930-6. PMID: 23609202.
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  136. Biermann JS, Adkins DR, Agulnik M, Benjamin RS, Brigman B, Butrynski JE, Cheong D, Chow W, Curry WT, Frassica DA, Frassica FJ, Hande KR, Hornicek FJ, Jones RL, Mayerson J, McGarry SV, McGrath B, Morris CD, O'Donnell RJ, Randall RL, Santana VM, Satcher RL, Siegel HJ, von Mehren M, Bergman MA, Sundar H. Bone cancer. J Natl Compr Canc Netw. 2013 Jun 01; 11(6):688-723. PMID: 23744868.
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  137. Kerr DA, Lopez HU, Deshpande V, Hornicek FJ, Duan Z, Zhang Y, Rosenberg AE, Borger DR, Nielsen GP. Molecular distinction of chondrosarcoma from chondroblastic osteosarcoma through IDH1/2 mutations. Am J Surg Pathol. 2013 Jun; 37(6):787-95. PMID: 23598960.
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  138. Demircay E, Hornicek FJ, Mankin HJ, Degroot H. Malignant lymphoma of bone: a review of 119 patients. Clin Orthop Relat Res. 2013 Aug; 471(8):2684-90. PMID: 23591933; PMCID: PMC3705030.
  139. Kobayashi E, Iyer AK, Hornicek FJ, Amiji MM, Duan Z. Lipid-functionalized dextran nanosystems to overcome multidrug resistance in cancer: a pilot study. Clin Orthop Relat Res. 2013 Mar; 471(3):915-25. PMID: 23011844; PMCID: PMC3563790.
  140. Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ. Giant cell tumor of bone. J Am Acad Orthop Surg. 2013 Feb; 21(2):118-26. PMID: 23378375.
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  141. Kang J, Botros M, Goldberg S, Giraud C, Nielsen GP, Chen YL, Raskin K, Schwab J, Yoon SS, Hornicek FJ, Delaney TF. The use of radiation therapy in the management of selected patients with atypical lipomas. Sarcoma. 2013; 2013:485483. PMID: 23401663; PMCID: PMC3562577.
  142. Mankin HJ, Hornicek FJ, DeLaney TF, Harmon DC, Schiller AL. Pleomorphic spindle cell sarcoma (PSCS) formerly known as malignant fibrous histiocytoma (MFH): a complex malignant soft-tissue tumor. Musculoskelet Surg. 2012 Dec; 96(3):171-7. PMID: 23129168.
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  143. Dunn GP, Spiliopoulos K, Plotkin SR, Hornicek FJ, Harmon DC, Delaney TF, Williams Z. Role of resection of malignant peripheral nerve sheath tumors in patients with neurofibromatosis type 1. J Neurosurg. 2013 Jan; 118(1):142-8. PMID: 23101443.
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  144. Look Hong NJ, Hornicek FJ, Harmon DC, Choy E, Chen YL, Yoon SS, Nielsen GP, Szymonifka J, Yeap BY, DeLaney TF, Mullen JT. Neoadjuvant chemoradiotherapy for patients with high-risk extremity and truncal sarcomas: a 10-year single institution retrospective study. Eur J Cancer. 2013 Mar; 49(4):875-83. PMID: 23092789; PMCID: PMC3777719.
  145. Schwab JH, Springfield DS, Raskin KA, Mankin HJ, Hornicek FJ. What's new in primary bone tumors. J Bone Joint Surg Am. 2012 Oct 17; 94(20):1913-9. PMID: 23079883.
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  146. Mullen JT, Delaney TF, Kobayashi WK, Szymonifka J, Yeap BY, Chen YL, Rosenberg AE, Harmon DC, Choy E, Yoon SS, Raskin KA, Petur Nielsen G, Hornicek FJ. Desmoid tumor: analysis of prognostic factors and outcomes in a surgical series. Ann Surg Oncol. 2012 Dec; 19(13):4028-35. PMID: 22965569.
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  147. Yang W, Liu X, Choy E, Mankin H, Hornicek FJ, Duan Z. Targeting hedgehog-GLI-2 pathway in osteosarcoma. J Orthop Res. 2013 Mar; 31(3):502-9. PMID: 22968906.
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  148. Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, Smith BL, Ferrone CR, Hornicek FJ, Boucher Y, Munn LL, Jain RK. Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15101-8. PMID: 22932871; PMCID: PMC3458380.
  149. Look Hong NJ, Hornicek FJ, Raskin KA, Yoon SS, Szymonifka J, Yeap B, Chen YL, DeLaney TF, Nielsen GP, Mullen JT. Prognostic factors and outcomes of patients with myxofibrosarcoma. Ann Surg Oncol. 2013 Jan; 20(1):80-6. PMID: 22890594; PMCID: PMC3837421.
  150. Duan Z, Zhang J, Choy E, Harmon D, Liu X, Nielsen P, Mankin H, Gray NS, Hornicek FJ. Systematic kinome shRNA screening identifies CDK11 (PITSLRE) kinase expression is critical for osteosarcoma cell growth and proliferation. Clin Cancer Res. 2012 Sep 01; 18(17):4580-8. PMID: 22791884.
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  151. Liu X, Nielsen GP, Rosenberg AE, Waterman PR, Yang W, Choy E, Sassi S, Yang S, Harmon DC, Yang C, Schwab JH, Kobayashi E, Mankin HJ, Xavier R, Weissleder R, Duan Z, Hornicek FJ. Establishment and characterization of a novel chordoma cell line: CH22. J Orthop Res. 2012 Oct; 30(10):1666-73. PMID: 22504929.
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  152. Boyaci B, Hornicek F, Rosenthal D, Mankin H, Pedlow FX, Carrier C, Harms J, Rosenberg A, Schwab J. Sarcoidosis of the spine: a report of five cases and a review of the literature. J Bone Joint Surg Am. 2012 Apr 04; 94(7):e42. PMID: 22488626.
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  153. Kobayashi E, Hornicek FJ, Duan Z. MicroRNA Involvement in Osteosarcoma. Sarcoma. 2012; 2012:359739. PMID: 22550419; PMCID: PMC3329862.
  154. Duan Z, Li X, Huang H, Yuan W, Zheng SL, Liu X, Zhang Z, Choy E, Harmon D, Mankin H, Hornicek F. Synthesis and evaluation of (2-(4-methoxyphenyl)-4-quinolinyl)(2-piperidinyl)methanol (NSC23925) isomers to reverse multidrug resistance in cancer. J Med Chem. 2012 Apr 12; 55(7):3113-21. PMID: 22400811.
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  155. Peacock ZS, Resnick CM, Susarla SM, Faquin WC, Rosenberg AE, Nielsen GP, Schwab JH, Hornicek F, Ebb DH, Dodson TB, Kaban LB. Do histologic criteria predict biologic behavior of giant cell lesions? J Oral Maxillofac Surg. 2012 Nov; 70(11):2573-80. PMID: 22365980.
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  156. Schoenfeld AJ, Hornicek FJ, Pedlow FX, Kobayashi W, Raskin KA, Springfield D, DeLaney TF, Nielsen GP, Mankin HJ, Schwab JH. Chondrosarcoma of the mobile spine: a review of 21 cases treated at a single center. Spine (Phila Pa 1976). 2012 Jan 15; 37(2):119-26. PMID: 22037533.
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  157. Mullen JT, Kobayashi W, Wang JJ, Harmon DC, Choy E, Hornicek FJ, Rosenberg AE, Chen YL, Spiro IJ, DeLaney TF. Long-term follow-up of patients treated with neoadjuvant chemotherapy and radiotherapy for large, extremity soft tissue sarcomas. Cancer. 2012 Aug 01; 118(15):3758-65. PMID: 22180344.
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  158. Choy E, Hornicek F, MacConaill L, Harmon D, Tariq Z, Garraway L, Duan Z. High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. Cancer. 2012 Jun 01; 118(11):2905-14. PMID: 22006429; PMCID: PMC3272156.
  159. Duan Z, Choy E, Harmon D, Liu X, Susa M, Mankin H, Hornicek F. MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration. Mol Cancer Ther. 2011 Aug; 10(8):1337-45. PMID: 21666078; PMCID: PMC3711153.
  160. Hartzell TL, Medina M, Hornicek FJ, Austen WG. Extended dermal apposition: a simple technique for the closure of irradiated perineal and sacral wounds. Plast Reconstr Surg. 2011 Jun; 127(6):170e-3e. PMID: 21617445.
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  161. Liu X, Choy E, Harmon D, Yang S, Yang C, Mankin H, Hornicek FJ, Duan Z. Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo. Anticancer Drugs. 2011 Jun; 22(5):444-53. PMID: 21399492.
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  162. Le LP, Nielsen GP, Rosenberg AE, Thomas D, Batten JM, Deshpande V, Schwab J, Duan Z, Xavier RJ, Hornicek FJ, Iafrate AJ. Recurrent chromosomal copy number alterations in sporadic chordomas. PLoS One. 2011; 6(5):e18846. PMID: 21602918; PMCID: PMC3094331.
  163. Yang C, Choy E, Hornicek FJ, Wood KB, Schwab JH, Liu X, Mankin H, Duan Z. Histone deacetylase inhibitor PCI-24781 enhances chemotherapy-induced apoptosis in multidrug-resistant sarcoma cell lines. Anticancer Res. 2011 Apr; 31(4):1115-23. PMID: 21508354; PMCID: PMC3744220.
  164. Ciernik IF, Niemierko A, Harmon DC, Kobayashi W, Chen YL, Yock TI, Ebb DH, Choy E, Raskin KA, Liebsch N, Hornicek FJ, Delaney TF. Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma. Cancer. 2011 Oct 01; 117(19):4522-30. PMID: 21448934; PMCID: PMC3716000.
  165. Liu X, Choy E, Hornicek FJ, Yang S, Yang C, Harmon D, Mankin H, Duan Z. ROCK1 as a potential therapeutic target in osteosarcoma. J Orthop Res. 2011 Aug; 29(8):1259-66. PMID: 21387396.
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  166. Henderson ER, Groundland JS, Pala E, Dennis JA, Wooten R, Cheong D, Windhager R, Kotz RI, Mercuri M, Funovics PT, Hornicek FJ, Temple HT, Ruggieri P, Letson GD. Failure mode classification for tumor endoprostheses: retrospective review of five institutions and a literature review. J Bone Joint Surg Am. 2011 Mar 02; 93(5):418-29. PMID: 21368074.
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  167. Mankin H, Trahan C, Hornicek F. Pigmented villonodular synovitis of joints. J Surg Oncol. 2011 Apr; 103(5):386-9. PMID: 21400520.
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  168. DeLaney TF, Duan Z, Hornicek FJ. Proteomic profiling of chordoma. J Surg Oncol. 2010 Dec 01; 102(7):719. PMID: 21104921.
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  169. Yoon SS, Duda DG, Karl DL, Kim TM, Kambadakone AR, Chen YL, Rothrock C, Rosenberg AE, Nielsen GP, Kirsch DG, Choy E, Harmon DC, Hornicek FJ, Dreyfuss J, Ancukiewicz M, Sahani DV, Park PJ, Jain RK, Delaney TF. Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas. Int J Radiat Oncol Biol Phys. 2011 Nov 15; 81(4):1081-90. PMID: 20932656; PMCID: PMC3021107.
  170. Mankin HJ, Hornicek FJ, Springfield DS. Extra-abdominal desmoid tumors: a report of 234 cases. J Surg Oncol. 2010 Oct 01; 102(5):380-4. PMID: 19877160.
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  171. Susa M, Choy E, Liu X, Schwab J, Hornicek FJ, Mankin H, Duan Z. Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking. Mol Cancer Ther. 2010 Dec; 9(12):3342-50. PMID: 20881269.
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  172. Devisetty K, Kobayashi W, Suit HD, Goldberg SI, Niemierko A, Chen YL, Raskin KA, Schwab JH, Springfield DS, Yoon SS, Hornicek FJ, DeLaney TF. Low-dose neoadjuvant external beam radiation therapy for soft tissue sarcoma. Int J Radiat Oncol Biol Phys. 2011 Jul 01; 80(3):779-86. PMID: 20864266.
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  173. Tejwani A, Kobayashi W, Chen YL, Rosenberg AE, Yoon S, Raskin KA, Rosenthal DI, Nielsen GP, Hornicek FJ, Delaney TF. Management of acral myxoinflammatory fibroblastic sarcoma. Cancer. 2010 Dec 15; 116(24):5733-9. PMID: 20737559.
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  174. Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Mankin H, Duan Z. Blockage of Stat3 with CDDO-Me inhibits tumor cell growth in chordoma. Spine (Phila Pa 1976). 2010 Aug 15; 35(18):1668-75. PMID: 20386502.
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  175. Guo Y, Nemeth J, O'Brien C, Susa M, Liu X, Zhang Z, Choy E, Mankin H, Hornicek F, Duan Z. Effects of siltuximab on the IL-6-induced signaling pathway in ovarian cancer. Clin Cancer Res. 2010 Dec 01; 16(23):5759-69. PMID: 20699329.
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  176. Schoenfeld AJ, Hornicek FJ, Pedlow FX, Kobayashi W, Garcia RT, DeLaney TF, Springfield D, Mankin HJ, Schwab JH. Osteosarcoma of the spine: experience in 26 patients treated at the Massachusetts General Hospital. Spine J. 2010 Aug; 10(8):708-14. PMID: 20650409.
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  177. Ryu K, Choy E, Yang C, Susa M, Hornicek FJ, Mankin H, Duan Z. Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis. J Orthop Res. 2010 Jul; 28(7):971-8. PMID: 20063378.
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  178. Duan Z, Choy E, Nielsen GP, Rosenberg A, Iafrate J, Yang C, Schwab J, Mankin H, Xavier R, Hornicek FJ. Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression. J Orthop Res. 2010 Jun; 28(6):746-52. PMID: 20041488.
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  179. Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Iafrate J, Rosenberg A, Nielsen GP, Xavier RJ, Mankin H, Duan Z. Characterization and analysis of human chordoma cell lines. Spine (Phila Pa 1976). 2010 Jun 01; 35(13):1257-64. PMID: 20461036; PMCID: PMC3769690.
  180. Biermann JS, Adkins DR, Benjamin RS, Brigman B, Chow W, Conrad EU, Frassica DA, Frassica FJ, George S, Hande KR, Hornicek FJ, Letson GD, Mayerson J, McGarry SV, McGrath B, Morris CD, O'Donnell RJ, Randall RL, Santana VM, Satcher RL, Siegel HJ, Somaiah N, Yasko AW. Bone cancer. J Natl Compr Canc Netw. 2010 Jun; 8(6):688-712. PMID: 20581300.
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  181. Susa M, Milane L, Amiji MM, Hornicek FJ, Duan Z. Nanoparticles: a promising modality in the treatment of sarcomas. Pharm Res. 2011 Feb; 28(2):260-72. PMID: 20505985.
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  182. Susa M, Iyer AK, Ryu K, Choy E, Hornicek FJ, Mankin H, Milane L, Amiji MM, Duan Z. Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma. PLoS One. 2010 May 24; 5(5):e10764. PMID: 20520719; PMCID: PMC2875382.
  183. Yang C, Choy E, Hornicek FJ, Wood KB, Schwab JH, Liu X, Mankin H, Duan Z. Histone deacetylase inhibitor (HDACI) PCI-24781 potentiates cytotoxic effects of doxorubicin in bone sarcoma cells. Cancer Chemother Pharmacol. 2011 Feb; 67(2):439-46. PMID: 20461381.
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  184. Ryu K, Susa M, Choy E, Yang C, Hornicek FJ, Mankin HJ, Duan Z. Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway. BMC Cancer. 2010 May 10; 10:187. PMID: 20459702; PMCID: PMC2874784.
  185. Schoenfeld AJ, Koplin SA, Garcia R, Hornicek FJ, Mankin HJ, Raskin KA, Springfield D, Rosenberg AE, Schwab JH. Monostotic fibrous dysplasia of the spine: a report of seven cases. J Bone Joint Surg Am. 2010 Apr; 92(4):984-8. PMID: 20360526.
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  186. Susa M, Choy E, Yang C, Schwab J, Mankin H, Hornicek F, Duan Z. Multidrug resistance reversal agent, NSC77037, identified with a cell-based screening assay. J Biomol Screen. 2010 Mar; 15(3):287-96. PMID: 20150589.
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  187. Duan Z, Ji D, Weinstein EJ, Liu X, Susa M, Choy E, Yang C, Mankin H, Hornicek FJ. Lentiviral shRNA screen of human kinases identifies PLK1 as a potential therapeutic target for osteosarcoma. Cancer Lett. 2010 Jul 28; 293(2):220-9. PMID: 20144850.
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  188. Resnick CM, Margolis J, Susarla SM, Schwab JH, Hornicek FJ, Dodson TB, Kaban LB. Maxillofacial and axial/appendicular giant cell lesions: unique tumors or variants of the same disease?--A comparison of phenotypic, clinical, and radiographic characteristics. J Oral Maxillofac Surg. 2010 Jan; 68(1):130-7. PMID: 20006167.
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  189. Yang C, Ji D, Weinstein EJ, Choy E, Hornicek FJ, Wood KB, Liu X, Mankin H, Duan Z. The kinase Mirk is a potential therapeutic target in osteosarcoma. Carcinogenesis. 2010 Apr; 31(4):552-8. PMID: 20042639; PMCID: PMC2847087.
  190. Koplin SA, Nielsen GP, Hornicek FJ, Rosenberg AE. Epithelioid sarcoma with heterotopic bone: a morphologic review of 4 cases. Int J Surg Pathol. 2010 Jun; 18(3):207-12. PMID: 20034988.
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  191. Kim B, Chen YL, Kirsch DG, Goldberg SI, Kobayashi W, Kung JH, Wolfgang JA, Doppke K, Rosenberg AE, Nielsen GP, Raskin KA, Springfield DS, Schwab JH, Gebhardt MC, Yoon SS, Hornicek FJ, DeLaney TF. An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local control. Int J Radiat Oncol Biol Phys. 2010 Jul 01; 77(3):843-50. PMID: 20005638.
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  192. Mito JK, Riedel RF, Dodd L, Lahat G, Lazar AJ, Dodd RD, Stangenberg L, Eward WC, Hornicek FJ, Yoon SS, Brigman BE, Jacks T, Lev D, Mukherjee S, Kirsch DG. Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma. PLoS One. 2009 Nov 30; 4(11):e8075. PMID: 19956606; PMCID: PMC2779485.
  193. Susa M, Iyer AK, Ryu K, Hornicek FJ, Mankin H, Amiji MM, Duan Z. Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma. BMC Cancer. 2009 Nov 16; 9:399. PMID: 19917123; PMCID: PMC2788581.
  194. Duan Z, Choy E, Hornicek FJ. NSC23925, identified in a high-throughput cell-based screen, reverses multidrug resistance. PLoS One. 2009 Oct 12; 4(10):e7415. PMID: 19823672; PMCID: PMC2757897.
  195. Duan Z, Choy E, Harmon D, Yang C, Ryu K, Schwab J, Mankin H, Hornicek FJ. ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines. PLoS One. 2009 Sep 09; 4(9):e6967. PMID: 19742314; PMCID: PMC2734182.
  196. Yang C, Schwab JH, Schoenfeld AJ, Hornicek FJ, Wood KB, Nielsen GP, Choy E, Mankin H, Duan Z. A novel target for treatment of chordoma: signal transducers and activators of transcription 3. Mol Cancer Ther. 2009 Sep; 8(9):2597-605. PMID: 19723879.
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  197. Duan Z, Choy E, Harmon D, Yang C, Ryu K, Schwab J, Mankin H, Hornicek FJ. Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines. Mol Cancer Ther. 2009 Aug; 8(8):2122-30. PMID: 19638450; PMCID: PMC2766237.
  198. Schwab J, Antonescu C, Boland P, Healey J, Rosenberg A, Nielsen P, Iafrate J, Delaney T, Yoon S, Choy E, Harmon D, Raskin K, Yang C, Mankin H, Springfield D, Hornicek F, Duan Z. Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma. Anticancer Res. 2009 Jun; 29(6):1867-71. PMID: 19528441.
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  199. Susa M, Morii T, Yabe H, Horiuchi K, Toyama Y, Weissbach L, Hornicek FJ, Morioka H. Alendronate inhibits growth of high-grade chondrosarcoma cells. Anticancer Res. 2009 Jun; 29(6):1879-88. PMID: 19528443.
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  200. Han S, Polizzano C, Nielsen GP, Hornicek FJ, Rosenberg AE, Ramesh V. Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas. Clin Cancer Res. 2009 Mar 15; 15(6):1940-6. PMID: 19276265; PMCID: PMC2701205.
  201. Maduekwe UN, Hornicek FJ, Springfield DS, Raskin KA, Harmon DC, Choy E, Rosenberg AE, Nielsen GP, DeLaney TF, Chen YL, Ott MJ, Yoon SS. Role of sentinel lymph node biopsy in the staging of synovial, epithelioid, and clear cell sarcomas. Ann Surg Oncol. 2009 May; 16(5):1356-63. PMID: 19259743.
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  202. Yang C, Hornicek FJ, Wood KB, Schwab JH, Mankin H, Duan Z. RAIDD expression is impaired in multidrug resistant osteosarcoma cell lines. Cancer Chemother Pharmacol. 2009 Aug; 64(3):607-14. PMID: 19125251.
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  203. Raskin KA, Hornicek F. Allograft reconstruction in malignant bone tumors: indications and limits. Recent Results Cancer Res. 2009; 179:51-8. PMID: 19230534.
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  204. Wagner TD, Kobayashi W, Dean S, Goldberg SI, Kirsch DG, Suit HD, Hornicek FJ, Pedlow FX, Raskin KA, Springfield DS, Yoon SS, Gebhardt MC, Mankin HJ, Delaney TF. Combination short-course preoperative irradiation, surgical resection, and reduced-field high-dose postoperative irradiation in the treatment of tumors involving the bone. Int J Radiat Oncol Biol Phys. 2009 Jan 01; 73(1):259-66. PMID: 19100921.
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  205. Yang C, Yang S, Wood KB, Hornicek FJ, Schwab JH, Fondren G, Mankin H, Duan Z. Multidrug resistant osteosarcoma cell lines exhibit deficiency of GADD45alpha expression. Apoptosis. 2009 Jan; 14(1):124-33. PMID: 19052873.
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  206. Sapkota BH, Hirsch AE, Yoo AJ, Hornicek FJ, Raskin KA, Rosenthal DI, Growney ML, Hirsch JA. Treatment of metastatic carcinoma to the hip with CT-guided percutaneous acetabuloplasty: report of four cases. J Vasc Interv Radiol. 2009 Apr; 20(4):548-52. PMID: 19112031.
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  207. DeLaney TF, Liebsch NJ, Pedlow FX, Adams J, Dean S, Yeap BY, McManus P, Rosenberg AE, Nielsen GP, Harmon DC, Spiro IJ, Raskin KA, Suit HD, Yoon SS, Hornicek FJ. Phase II study of high-dose photon/proton radiotherapy in the management of spine sarcomas. Int J Radiat Oncol Biol Phys. 2009 Jul 01; 74(3):732-9. PMID: 19095372; PMCID: PMC2734911.
  208. Duan Z, Choy E, Jimeno JM, Cuevas Cdel M, Mankin HJ, Hornicek FJ. Diverse cross-resistance phenotype to ET-743 and PM00104 in multi-drug resistant cell lines. Cancer Chemother Pharmacol. 2009 May; 63(6):1121-9. PMID: 18828019.
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  209. Kaufman AM, Abraham JA, Kattapuram SV, Hornicek FJ. Orthopaedic . radiology . pathology conference: Chronic multifocal chest and leg pain in a 34-year-old woman. Clin Orthop Relat Res. 2009 Apr; 467(4):1112-7. PMID: 18810567; PMCID: PMC2650065.
  210. Berry M, Mankin H, Gebhardt M, Rosenberg A, Hornicek F. Osteoblastoma: a 30-year study of 99 cases. J Surg Oncol. 2008 Sep 01; 98(3):179-83. PMID: 18561158.
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  211. Hartzell TL, Hornicek FJ, Austen WG. Latissimus dorsi flap closure of the irradiated clavicular wound. J Shoulder Elbow Surg. 2008 Nov-Dec; 17(6):875-80. PMID: 18760634.
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  212. Duan Z, Weinstein EJ, Ji D, Ames RY, Choy E, Mankin H, Hornicek FJ. Lentiviral short hairpin RNA screen of genes associated with multidrug resistance identifies PRP-4 as a new regulator of chemoresistance in human ovarian cancer. Mol Cancer Ther. 2008 Aug; 7(8):2377-85. PMID: 18687998; PMCID: PMC2597512.
  213. Sung AD, Anderson ME, Zurakowski D, Hornicek FJ, Gebhardt MC. Unicameral bone cyst: a retrospective study of three surgical treatments. Clin Orthop Relat Res. 2008 Oct; 466(10):2519-26. PMID: 18679761; PMCID: PMC2584314.
  214. Parrett BM, Winograd JM, Garfein ES, Lee WP, Hornicek FJ, Austen WG. The vertical and extended rectus abdominis myocutaneous flap for irradiated thigh and groin defects. Plast Reconstr Surg. 2008 Jul; 122(1):171-7. PMID: 18594402.
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  215. Duan Z, Ames RY, Ryan M, Hornicek FJ, Mankin H, Seiden MV. CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells. Cancer Chemother Pharmacol. 2009 Mar; 63(4):681-9. PMID: 18587580; PMCID: PMC2875930.
  216. Sawamura C, Hornicek FJ, Gebhardt MC. Complications and risk factors for failure of rotationplasty: review of 25 patients. Clin Orthop Relat Res. 2008 Jun; 466(6):1302-8. PMID: 18404295; PMCID: PMC2384038.
  217. Kharrazi FD, Busfield BT, Khorshad DS, Hornicek FJ, Mankin HJ. Knee mass from severe metallosis after failure of a metal-backed patellar component total knee arthroplasty. Am J Orthop (Belle Mead NJ). 2008 Feb; 37(2):E38-41. PMID: 18401493.
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  218. Kharrazi FD, Busfield BT, Khorshad DS, Hornicek FJ, Mankin HJ. Osteoarticular and total elbow allograft reconstruction with severe bone loss. Clin Orthop Relat Res. 2008 Jan; 466(1):205-9. PMID: 18196394; PMCID: PMC2505305.
  219. Hornicek FJ. RE: local control in nonmetastatic pelvic Ewing's sarcoma patients: Outcome and analysis, by Donati, D, et al. J Surg Oncol. 2007 Nov 01; 96(6):453-4. PMID: 17654523.
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  220. Bredella MA, Torriani M, Hornicek F, Ouellette HA, Plamer WE, Williams Z, Fischman AJ, Plotkin SR. Value of PET in the assessment of patients with neurofibromatosis type 1. AJR Am J Roentgenol. 2007 Oct; 189(4):928-35. PMID: 17885067.
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  221. Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T. A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med. 2007 Aug; 13(8):992-7. PMID: 17676052.
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  222. Geller DS, Hornicek FJ, Mankin HJ, Raskin KA. Soft tissue sarcoma resection volume associated with wound-healing complications. Clin Orthop Relat Res. 2007 Jun; 459:182-5. PMID: 17452922.
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  223. Sah AP, Geller DS, Mankin HJ, Rosenberg AE, Delaney TF, Wright CD, Hornicek FJ. Malignant transformation of synovial chondromatosis of the shoulder to chondrosarcoma. A case report. J Bone Joint Surg Am. 2007 Jun; 89(6):1321-8. PMID: 17545437.
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  224. Mourikis A, Mankin HJ, Hornicek FJ, Raskin KA. Treatment of proximal humeral chondrosarcoma with resection and allograft. J Shoulder Elbow Surg. 2007 Sep-Oct; 16(5):519-24. PMID: 17521925.
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  225. Malchau SS, Hayden J, Hornicek F, Mankin HJ. Clear cell sarcoma of soft tissues. J Surg Oncol. 2007 May 01; 95(6):519-22. PMID: 17192915.
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  226. Kattapuram TM, Ozhathil DK, Hornicek FJ, Gebhardt MC, Mankin HJ, Rosenberg AE, Kattapuram SV. Imaging of pseudoneoplastic masses associated with allografts. Skeletal Radiol. 2007 Aug; 36(8):747-53. PMID: 17415562.
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  227. Delaney TF, Kepka L, Goldberg SI, Hornicek FJ, Gebhardt MC, Yoon SS, Springfield DS, Raskin KA, Harmon DC, Kirsch DG, Mankin HJ, Rosenberg AE, Nielsen GP, Suit HD. Radiation therapy for control of soft-tissue sarcomas resected with positive margins. Int J Radiat Oncol Biol Phys. 2007 Apr 01; 67(5):1460-9. PMID: 17394945.
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  228. Abraham JA, Hornicek FJ, Kaufman AM, Harmon DC, Springfield DS, Raskin KA, Mankin HJ, Kirsch DG, Rosenberg AE, Nielsen GP, Desphpande V, Suit HD, DeLaney TF, Yoon SS. Treatment and outcome of 82 patients with angiosarcoma. Ann Surg Oncol. 2007 Jun; 14(6):1953-67. PMID: 17356953.
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  229. Buecker PJ, Berenstein M, Gebhardt MC, Hornicek FJ, Mankin HJ. Locking versus standard plates for allograft fixation after tumor resection in children and adolescents. J Pediatr Orthop. 2006 Sep-Oct; 26(5):680-5. PMID: 16932111.
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  230. Park L, Delaney TF, Liebsch NJ, Hornicek FJ, Goldberg S, Mankin H, Rosenberg AE, Rosenthal DI, Suit HD. Sacral chordomas: Impact of high-dose proton/photon-beam radiation therapy combined with or without surgery for primary versus recurrent tumor. Int J Radiat Oncol Biol Phys. 2006 Aug 01; 65(5):1514-21. PMID: 16757128.
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  231. Campbell J, Rosenthal DI, Raskin KA, Hornicek FJ, Michaelson MD. Use of an arterial tourniquet to achieve complete radiofrequency ablation of a renal metastasis. J Vasc Interv Radiol. 2006 Jun; 17(6):1051-5. PMID: 16778241.
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  232. Buecker PJ, Villafuerte JE, Hornicek FJ, Gebhardt MC, Mankin HJ. Improved survival for sarcomas of the wrist and hand. J Hand Surg Am. 2006 Mar; 31(3):452-5. PMID: 16516741.
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  233. Kepka L, Suit HD, Goldberg SI, Rosenberg AE, Gebhardt MC, Hornicek FJ, Delaney TF. Results of radiation therapy performed after unplanned surgery (without re-excision) for soft tissue sarcomas. J Surg Oncol. 2005 Oct 01; 92(1):39-45. PMID: 16180232.
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  234. Mankin HJ, Hornicek FJ. Treatment of giant cell tumors with allograft transplants: a 30-year study. Clin Orthop Relat Res. 2005 Oct; 439:144-50. PMID: 16205153.
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  235. Lersundi A, Mankin HJ, Mourikis A, Hornicek FJ. Chondromyxoid fibroma: a rarely encountered and puzzling tumor. Clin Orthop Relat Res. 2005 Oct; 439:171-5. PMID: 16205156.
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  236. Mankin HJ, Hornicek FJ, Ortiz-Cruz E, Villafuerte J, Gebhardt MC. Aneurysmal bone cyst: a review of 150 patients. J Clin Oncol. 2005 Sep 20; 23(27):6756-62. PMID: 16170183.
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  237. Mankin HJ, Hornicek FJ, Harris M. Total femur replacement procedures in tumor treatment. Clin Orthop Relat Res. 2005 Sep; 438:60-4. PMID: 16131870.
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  238. Anderson ME, Hornicek FJ, Gebhardt MC, Raskin KA, Mankin HJ. Alveolar soft part sarcoma: a rare and enigmatic entity. Clin Orthop Relat Res. 2005 Sep; 438:144-8. PMID: 16131883.
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  239. Mankin HJ, Hornicek FJ. Paget's sarcoma: a historical and outcome review. Clin Orthop Relat Res. 2005 Sep; 438:97-102. PMID: 16131876.
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  240. Mankin HJ, Hornicek FJ. Internal hemipelvectomy for the management of pelvic sarcomas. Surg Oncol Clin N Am. 2005 Apr; 14(2):381-96. PMID: 15817245.
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  241. Mankin HJ, Hornicek FJ, Raskin KA. Infection in massive bone allografts. Clin Orthop Relat Res. 2005 Mar; (432):210-6. PMID: 15738824.
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  242. Mankin HJ, Hornicek FJ. Diagnosis, classification, and management of soft tissue sarcomas. Cancer Control. 2005 Jan-Feb; 12(1):5-21. PMID: 15668648.
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  243. Marchini S, Marrazzo E, Bonomi R, Chiorino G, Zaffaroni M, Weissbach L, Hornicek FJ, Broggini M, Faircloth GT, D'Incalci M. Molecular characterisation of two human cancer cell lines selected in vitro for their chemotherapeutic drug resistance to ET-743. Eur J Cancer. 2005 Jan; 41(2):323-33. PMID: 15661559.
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  244. Mankin HJ, Hornicek FJ, Rosenberg AE, Harmon DC, Gebhardt MC. Survival data for 648 patients with osteosarcoma treated at one institution. Clin Orthop Relat Res. 2004 Dec; (429):286-91. PMID: 15577500.
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  245. Mankin HJ, Gunnoe J, Farid Y, Hornicek FJ, Gebhardt MC. Long-term effects of connective tissue cancer treatment. Clin Orthop Relat Res. 2004 Sep; (426):74-86. PMID: 15346055.
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  246. Cashen DV, Parisien RC, Raskin K, Hornicek FJ, Gebhardt MC, Mankin HJ. Survival data for patients with malignant schwannoma. Clin Orthop Relat Res. 2004 Sep; (426):69-73. PMID: 15346054.
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  247. Mankin HJ, Hornicek FJ, Temple HT, Gebhardt MC. Malignant tumors of the pelvis: an outcome study. Clin Orthop Relat Res. 2004 Aug; (425):212-7. PMID: 15292810.
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  248. Young-In Lee F, Hornicek FJ, Dick HM, Mankin HJ. Synovial chondromatosis of the foot. Clin Orthop Relat Res. 2004 Jun; (423):186-90. PMID: 15232447.
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  249. Lewandrowski KU, Hecht AC, DeLaney TF, Chapman PA, Hornicek FJ, Pedlow FX. Anterior spinal arthrodesis with structural cortical allografts and instrumentation for spine tumor surgery. Spine (Phila Pa 1976). 2004 May 15; 29(10):1150-8; discussion 1159. PMID: 15131446.
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  250. Zeytoonjian T, Mankin HJ, Gebhardt MC, Hornicek FJ. Distal lower extremity sarcomas: frequency of occurrence and patient survival rate. Foot Ankle Int. 2004 May; 25(5):325-30. PMID: 15134614.
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  251. Brigman BE, Hornicek FJ, Gebhardt MC, Mankin HJ. Allografts about the Knee in Young Patients with High-Grade Sarcoma. Clin Orthop Relat Res. 2004 Apr; (421):232-9. PMID: 15123953.
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  252. Mankin HJ, Casas-Ganem J, Kim JI, Gebhardt MC, Hornicek FJ, Zeegen EN. Leiomyosarcoma of somatic soft tissues. Clin Orthop Relat Res. 2004 Apr; (421):225-31. PMID: 15123952.
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  253. Zeegen EN, Aponte-Tinao LA, Hornicek FJ, Gebhardt MC, Mankin HJ. Survivorship analysis of 141 modular metallic endoprostheses at early followup. Clin Orthop Relat Res. 2004 Mar; (420):239-50. PMID: 15057104.
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  254. Shao L, Kasanov J, Hornicek FJ, Morii T, Fondren G, Weissbach L. Ecteinascidin-743 drug resistance in sarcoma cells: transcriptional and cellular alterations. Biochem Pharmacol. 2003 Dec 15; 66(12):2381-95. PMID: 14637196.
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  255. DeLaney TF, Chen GT, Mauceri TC, Munro JJ, Hornicek FJ, Pedlow FX, Suit HD. Intraoperative dural irradiation by customized 192iridium and 90yttrium brachytherapy plaques. Int J Radiat Oncol Biol Phys. 2003 Sep 01; 57(1):239-45. PMID: 12909239.
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  256. Rosenthal DI, Hornicek FJ, Torriani M, Gebhardt MC, Mankin HJ. Osteoid osteoma: percutaneous treatment with radiofrequency energy. Radiology. 2003 Oct; 229(1):171-5. PMID: 12944597.
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  257. DeLaney TF, Spiro IJ, Suit HD, Gebhardt MC, Hornicek FJ, Mankin HJ, Rosenberg AL, Rosenthal DI, Miryousefi F, Ancukiewicz M, Harmon DC. Neoadjuvant chemotherapy and radiotherapy for large extremity soft-tissue sarcomas. Int J Radiat Oncol Biol Phys. 2003 Jul 15; 56(4):1117-27. PMID: 12829150.
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  258. Morioka H, Morii T, Vogel T, Hornicek FJ, Weissbach L. Interaction of plasminogen-related protein B with endothelial and smooth muscle cells in vitro. Exp Cell Res. 2003 Jul 01; 287(1):166-77. PMID: 12799192.
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  259. Rodriguez EK, Hornicek FJ, Gebhardt MC, Mankin HJ. Metachronous osteosarcoma: a report of five cases. Clin Orthop Relat Res. 2003 Jun; (411):227-35. PMID: 12782879.
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  260. Morioka H, Weissbach L, Vogel T, Nielsen GP, Faircloth GT, Shao L, Hornicek FJ. Antiangiogenesis treatment combined with chemotherapy produces chondrosarcoma necrosis. Clin Cancer Res. 2003 Mar; 9(3):1211-7. PMID: 12631627.
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  261. Rosenthal DI, Marota JJ, Hornicek FJ. Osteoid osteoma: elevation of cardiac and respiratory rates at biopsy needle entry into tumor in 10 patients. Radiology. 2003 Jan; 226(1):125-8. PMID: 12511680.
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  262. Kaban LB, Troulis MJ, Ebb D, August M, Hornicek FJ, Dodson TB. Antiangiogenic therapy with interferon alpha for giant cell lesions of the jaws. J Oral Maxillofac Surg. 2002 Oct; 60(10):1103-11; discussion 1111-3. PMID: 12378481.
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  263. Tang P, Hornicek FJ, Gebhardt MC, Cates J, Mankin HJ. Surgical treatment of hemangiomas of soft tissue. Clin Orthop Relat Res. 2002 Jun; (399):205-10. PMID: 12011711.
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  264. Sami S, Liu G, Hornicek F, Cates JM, Mankin HJ. Membranous lipodystrophy. A case report. J Bone Joint Surg Am. 2002 Apr; 84-A(4):630-3. PMID: 11940627.
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  265. Fox EJ, Hau MA, Gebhardt MC, Hornicek FJ, Tomford WW, Mankin HJ. Long-term followup of proximal femoral allografts. Clin Orthop Relat Res. 2002 Apr; (397):106-13. PMID: 11953602.
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  266. Mankin HJ, Fondren G, Hornicek FJ, Gebhardt MC, Rosenberg AE. The use of flow cytometry in assessing malignancy in bone and soft tissue tumors. Clin Orthop Relat Res. 2002 Apr; (397):95-105. PMID: 11953601.
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  267. Refaat Y, Gunnoe J, Hornicek FJ, Mankin HJ. Comparison of quality of life after amputation or limb salvage. Clin Orthop Relat Res. 2002 Apr; (397):298-305. PMID: 11953621.
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  268. Hau A, Kim I, Kattapuram S, Hornicek FJ, Rosenberg AE, Gebhardt MC, Mankin HJ. Accuracy of CT-guided biopsies in 359 patients with musculoskeletal lesions. Skeletal Radiol. 2002 Jun; 31(6):349-53. PMID: 12073119.
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  269. Berven S, Zurakowski D, Mankin HJ, Gebhardt MC, Springfield DS, Hornicek FJ. Clinical outcome in chordoma: utility of flow cytometry in DNA determination. Spine (Phila Pa 1976). 2002 Feb 15; 27(4):374-9. PMID: 11840103.
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  270. Hornicek FJ, Zych GA, Hutson JJ, Malinin TI. Salvage of humeral nonunions with onlay bone plate allograft augmentation. Clin Orthop Relat Res. 2001 May; (386):203-9. PMID: 11347837.
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  271. Hazan EJ, Hornicek FJ, Tomford W, Gebhardt MC, Mankin HJ. The effect of adjuvant chemotherapy on osteoarticular allografts. Clin Orthop Relat Res. 2001 Apr; (385):176-81. PMID: 11302311.
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  272. Sorger JI, Hornicek FJ, Zavatta M, Menzner JP, Gebhardt MC, Tomford WW, Mankin HJ. Allograft fractures revisited. Clin Orthop Relat Res. 2001 Jan; (382):66-74. PMID: 11154007.
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  273. Hornicek FJ, Gebhardt MC, Tomford WW, Sorger JI, Zavatta M, Menzner JP, Mankin HJ. Factors affecting nonunion of the allograft-host junction. Clin Orthop Relat Res. 2001 Jan; (382):87-98. PMID: 11154010.
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  274. Boyle MJ, Hornicek FJ, Robinson DS, Mnaymneh W. Internal hemipelvectomy for solitary pelvic thyroid cancer metastases. J Surg Oncol. 2000 Sep; 75(1):3-10. PMID: 11025455.
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  275. Hornicek FJ, Gebhardt MC, Wolfe MW, Kharrazi FD, Takeshita H, Parekh SG, Zurakowski D, Mankin HJ. P-glycoprotein levels predict poor outcome in patients with osteosarcoma. Clin Orthop Relat Res. 2000 Apr; (373):11-7. PMID: 10810457.
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  276. Hornicek FJ, Gebhardt MC, Sorger JI, Mankin HJ. Tumor reconstruction. Orthop Clin North Am. 1999 Oct; 30(4):673-84. PMID: 10471771.
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  277. Reith JD, Donahue FI, Hornicek FJ. Dedifferentiated parosteal osteosarcoma with rhabdomyosarcomatous differentiation. Skeletal Radiol. 1999 Sep; 28(9):527-31. PMID: 10525797.
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  278. Rosenthal DI, Hornicek FJ, Wolfe MW, Jennings LC, Gebhardt MC, Mankin HJ. Decreasing length of hospital stay in treatment of osteoid osteoma. Clin Orthop Relat Res. 1999 Apr; (361):186-91. PMID: 10212612.
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  279. Lee FY, Hornicek FJ, Hazan EJ, Kloen P, Wolfe MA, Mankin HJ. Reconstruction of the shoulder joint using an acetabular allograft. A report of two cases. Clin Orthop Relat Res. 1998 Dec; (357):116-21. PMID: 9917707.
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  280. Hornicek FJ, Mnaymneh W, Lackman RD, Exner GU, Malinin TI. Limb salvage with osteoarticular allografts after resection of proximal tibia bone tumors. Clin Orthop Relat Res. 1998 Jul; (352):179-86. PMID: 9678046.
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  281. Rosenthal DI, Hornicek FJ, Wolfe MW, Jennings LC, Gebhardt MC, Mankin HJ. Percutaneous radiofrequency coagulation of osteoid osteoma compared with operative treatment. J Bone Joint Surg Am. 1998 Jun; 80(6):815-21. PMID: 9655099.
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  282. McAuliffe JA, Seltzer DG, Hornicek FJ. Upper-extremity infections in patients seropositive for human immunodeficiency virus. J Hand Surg Am. 1997 Nov; 22(6):1084-90. PMID: 9471082.
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  283. Brown MD, Hornicek FJ, Lebwohl NH. Phantom sciatica. A case report. J Bone Joint Surg Am. 1997 Feb; 79(2):252-3. PMID: 9052548.
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  284. Mnaymneh W, Malinin TI, Lackman RD, Hornicek FJ, Ghandur-Mnaymneh L. Massive distal femoral osteoarticular allografts after resection of bone tumors. Clin Orthop Relat Res. 1994 Jun; (303):103-15. PMID: 8194220.
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  285. Renfree KJ, Banovac K, Hornicek FJ, Lebwohl NH, Villanueva PA, Nedd KJ. Evaluation of serum osteoblast mitogenic activity in spinal cord and head injury patients with acute heterotopic ossification. Spine (Phila Pa 1976). 1994 Apr 01; 19(7):740-6. PMID: 8202789.
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  286. Hornicek FJ, Malinin GI, Banovac K, Malinin TI. Morphologic and metabolic changes in rat osteoblast cultures during the dark reaction with 8-methoxypsoralen. Chem Biol Interact. 1994 Feb; 90(2):185-93. PMID: 8156607.
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  287. Hornicek FJ, Malinin GI, Malinin TI, Lo HK. Turnover of phospholipids in HUT 102 lymphoblasts and chromatographic characterization of purified lecithins after their exposure to long-wave UV light, psoralen, and UV light and psoralen. J Photochem Photobiol B. 1992 Mar 13; 12(4):359-74. PMID: 1578297.
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  288. Hornicek FJ, Malinin GI, Malinin TI. Calcium is required for the mitogenic activation of lymphocytes by periodic acid oxidation. Biochem Biophys Res Commun. 1992 Feb 28; 183(1):144-9. PMID: 1311920.
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  289. Pollice AA, McCoy JP, Shackney SE, Smith CA, Agarwal J, Burholt DR, Janocko LE, Hornicek FJ, Singh SG, Hartsock RJ. Sequential paraformaldehyde and methanol fixation for simultaneous flow cytometric analysis of DNA, cell surface proteins, and intracellular proteins. Cytometry. 1992; 13(4):432-44. PMID: 1382010.
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  290. Malinin GI, Hornicek FJ, Malinin TI. Enhanced protein phosphorylation, IL-2 receptor expression, and IL-2 production precede cellular proliferation in lymphocytes oxidized by periodic acid. Biochem Biophys Res Commun. 1989 Jan 31; 158(2):590-4. PMID: 2537077.
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  291. Thornthwaite JT, Loutzenhiser K, Hornicek FJ, Donahue R, Allen LM. Flow cytometric enumeration of colonies for in vitro chemotherapeutic drug evaluation. Cytometry. 1989 Jan; 10(1):98-102. PMID: 2537169.
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  292. Zakarija M, Hornicek FJ, Levis S, McKenzie JM. Effects of gamma-interferon and tumor necrosis factor alpha on thyroid cells: induction of class II antigen and inhibition of growth stimulation. Mol Cell Endocrinol. 1988 Aug; 58(2-3):129-36. PMID: 3145228.
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  293. Hornicek FJ, Reese DH, Lo HK, Malinin TI, Malinin GI. Periodic acid-induced blastogenesis of lymphocytes is independent of phosphoinositide turnover. Biochem Biophys Res Commun. 1988 Jul 29; 154(2):606-12. PMID: 2840902.
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  294. Hornicek FJ, Reiss E, Malinin TI, Malinin GI. Establishment of primary cell cultures from human and canine parathyroid gland explants. Bone Miner. 1988 Jun; 4(2):157-65. PMID: 3191278.
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  295. Malinin TI, Hornicek FJ, Block NL, Malinin GI. Aneuploidy of glandular epithelial cells in histologically normal prostate glands. Experientia. 1988 Mar 15; 44(3):247-9. PMID: 3350136.
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