Harvard Catalyst Profiles

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David Mahan Knipe, Ph.D.

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Other Positions
Title
Institution
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01AI106934 (KNIPE, DAVID M.) Apr 15, 2014 - Jul 31, 2022
    NIH
    Nuclear Sensing of Herpesviral DNA
    Role: Principal Investigator
  2. R56DE023909 (KNIPE, DAVID M.) Sep 21, 2013 - Aug 31, 2017
    NIH
    Epigenetic Regulation of HSV Infection of Oral Cells
    Role: Principal Investigator
  3. P01AI098681 (COEN, DONALD M) Jul 2, 2013 - Jul 31, 2024
    NIH
    VIral and host mechanisms that tilt the HSV lytic/latent balance
    Role: Co-Principal Investigator
  4. R01AI099081 (KNIPE, DAVID M.) Feb 1, 2012 - Jan 31, 2017
    NIH
    Chromatin and Herpes Simplex Virus Latency
    Role: Principal Investigator
  5. R01AI057552 (KNIPE, DAVID M.) Dec 1, 2003 - Jun 30, 2017
    NIH
    International Herpes Vaccine Project
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Leon J, Michelson DA, Olejnik J, Chowdhary K, Oh HS, Hume AJ, Galván-Peña S, Zhu Y, Chen F, Vijaykumar B, Yang L, Crestani E, Yonker LM, Knipe DM, Mühlberger E, Benoist C. A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune-epithelial interface. Proc Natl Acad Sci U S A. 2022 01 04; 119(1). PMID: 34969849.
    Citations:    Fields:    Translation:HumansCells
  2. van Gent M, Chiang JJ, Muppala S, Chiang C, Azab W, Kattenhorn L, Knipe DM, Osterrieder N, Gack MU. The US3 Kinase of Herpes Simplex Virus Phosphorylates the RNA Sensor RIG-I To Suppress Innate Immunity. J Virol. 2022 02 23; 96(4):e0151021. PMID: 34935440.
    Citations: 1     Fields:    Translation:HumansCells
  3. Peng T, Phasouk K, Sodroski CN, Sun S, Hwangbo Y, Layton ED, Jin L, Klock A, Diem K, Magaret AS, Jing L, Laing K, Li A, Huang ML, Mertens M, Johnston C, Jerome KR, Koelle DM, Wald A, Knipe DM, Corey L, Zhu J. Tissue-Resident-Memory CD8+ T Cells Bridge Innate Immune Responses in Neighboring Epithelial Cells to Control Human Genital Herpes. Front Immunol. 2021; 12:735643. PMID: 34552595.
    Citations:    Fields:    Translation:HumansCells
  4. Kaugars K, Dardick J, de Oliveira AP, Weiss KA, Lukose R, Kim J, Leung L, Rajagopalan S, Wolin S, Akabas L, Knipe DM, Bajic G, Jacobs WR. A recombinant herpes virus expressing influenza hemagglutinin confers protection and induces antibody-dependent cellular cytotoxicity. Proc Natl Acad Sci U S A. 2021 08 24; 118(34). PMID: 34417304.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. Stubbs SH, Cornejo Pontelli M, Mishra N, Zhou C, de Paula Souza J, Mendes Viana RM, Lipkin WI, Knipe DM, Arruda E, Whelan SPJ. Vesicular Stomatitis Virus Chimeras Expressing the Oropouche Virus Glycoproteins Elicit Protective Immune Responses in Mice. mBio. 2021 08 31; 12(4):e0046321. PMID: 34340542.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Cabral JM, Cushman CH, Sodroski CN, Knipe DM. ATRX limits the accessibility of histone H3-occupied HSV genomes during lytic infection. PLoS Pathog. 2021 04; 17(4):e1009567. PMID: 33909709.
    Citations: 2     Fields:    Translation:HumansCells
  7. Kurt-Jones EA, Dudek TE, Watanabe D, Mandell L, Che J, Zhou S, Cao L, Greenough T, Babcock GJ, Diaz F, Oh HS, Zhou C, Finberg RW, Knipe DM. Expression of SARS coronavirus 1 spike protein from a herpesviral vector induces innate immune signaling and neutralizing antibody responses. Virology. 2021 07; 559:165-172. PMID: 33930819.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  8. Mertens ME, Knipe DM. Herpes Simplex Virus 1 Manipulates Host Cell Antiviral and Proviral DNA Damage Responses. mBio. 2021 02 09; 12(1). PMID: 33563816.
    Citations: 4     Fields:    Translation:HumansCells
  9. Sun B, Yang X, Hou F, Yu X, Wang Q, Oh HS, Raja P, Pesola JM, Vanni EAH, McCarron S, Morris-Love J, Ng AHM, Church GM, Knipe DM, Coen DM, Pan D. Regulation of host and virus genes by neuronal miR-138 favours herpes simplex virus 1 latency. Nat Microbiol. 2021 05; 6(5):682-696. PMID: 33558653.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  10. Reddi TS, Merkl PE, Lim SY, Letvin NL, Knipe DM. Tripartite Motif 22 (TRIM22) protein restricts herpes simplex virus 1 by epigenetic silencing of viral immediate-early genes. PLoS Pathog. 2021 02; 17(2):e1009281. PMID: 33524065.
    Citations: 7     Fields:    Translation:HumansCells
  11. Knipe DM, Levy O, Fitzgerald KA, Mühlberger E. Ensuring vaccine safety. Science. 2020 12 11; 370(6522):1274-1275. PMID: 33203781.
    Citations: 3     Fields:    Translation:HumansAnimals
  12. Neuhausser WM, Oh HS, Eggan P, Angelova M, Kirchner R, Eggan KC, Knipe DM. Screening Method for CRISPR/Cas9 Inhibition of a Human DNA Virus: Herpes Simplex Virus. Bio Protoc. 2020 Sep 05; 10(17):e3748. PMID: 33659408.
    Citations: 1     
  13. Burn Aschner C, Pierce C, Knipe DM, Herold BC. Vaccination Route as a Determinant of Protective Antibody Responses against Herpes Simplex Virus. Vaccines (Basel). 2020 Jun 05; 8(2). PMID: 32516944.
    Citations: 6     
  14. Burn Aschner C, Knipe DM, Herold BC. Model of vaccine efficacy against HSV-2 superinfection of HSV-1 seropositive mice demonstrates protection by antibodies mediating cellular cytotoxicity. NPJ Vaccines. 2020; 5(1):35. PMID: 32411398.
    Citations: 9     
  15. Burn Aschner C, Knipe DM, Herold BC. Model of vaccine efficacy against HSV-2 superinfection of HSV-1 seropositive mice demonstrates protection by antibodies mediating cellular cytotoxicity. NPJ Vaccines. 2020 May 07; 5(1):35. PMID: 33580077.
    Citations:    
  16. Crowley SJ, Bruck PT, Bhuiyan MA, Mitchell-Gears A, Walsh MJ, Zhangxu K, Ali LR, Jeong HJ, Ingram JR, Knipe DM, Ploegh HL, Dougan M, Dougan SK. Neoleukin-2 enhances anti-tumour immunity downstream of peptide vaccination targeted by an anti-MHC class II VHH. Open Biol. 2020 02; 10(2):190235. PMID: 32019478.
    Citations: 3     Fields:    Translation:AnimalsCells
  17. Oh HS, Neuhausser WM, Eggan P, Angelova M, Kirchner R, Eggan KC, Knipe DM. Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9. Elife. 2019 12 02; 8. PMID: 31789594.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  18. Claiborne DT, Dudek TE, Maldini CR, Power KA, Ghebremichael M, Seung E, Mellors EF, Vrbanac VD, Krupp K, Bisesi A, Tager AM, Knipe DM, Boutwell CL, Allen TM. Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia. J Virol. 2019 10 15; 93(20). PMID: 31375576.
    Citations: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  19. Patel CD, Backes IM, Taylor SA, Jiang Y, Marchant A, Pesola JM, Coen DM, Knipe DM, Ackerman ME, Leib DA. Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity. Sci Transl Med. 2019 04 10; 11(487). PMID: 30971454.
    Citations: 14     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  20. Pan D, Li G, Morris-Love J, Qi S, Feng L, Mertens ME, Jurak I, Knipe DM, Coen DM. Herpes Simplex Virus 1 Lytic Infection Blocks MicroRNA (miRNA) Biogenesis at the Stage of Nuclear Export of Pre-miRNAs. mBio. 2019 02 12; 10(1). PMID: 30755517.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  21. Merkl PE, Knipe DM. Role for a Filamentous Nuclear Assembly of IFI16, DNA, and Host Factors in Restriction of Herpesviral Infection. mBio. 2019 01 22; 10(1). PMID: 30670617.
    Citations: 27     Fields:    Translation:HumansCells
  22. Boscheinen JB, Thomann S, Knipe DM, DeLuca N, Schuler-Thurner B, Gross S, Dörrie J, Schaft N, Bach C, Rohrhofer A, Werner-Klein M, Schmidt B, Schuster P. Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA. Front Immunol. 2019; 10:2. PMID: 30723467.
    Citations: 2     Fields:    Translation:HumansCells
  23. Zmasek CM, Knipe DM, Pellett PE, Scheuermann RH. Classification of human Herpesviridae proteins using Domain-architecture Aware Inference of Orthologs (DAIO). Virology. 2019 03; 529:29-42. PMID: 30660046.
    Citations: 3     Fields:    Translation:Cells
  24. Cabral JM, Oh HS, Knipe DM. ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress. Elife. 2018 11 22; 7. PMID: 30465651.
    Citations: 26     Fields:    Translation:HumansCells
  25. Chen Y, Sharma S, Assis PA, Jiang Z, Elling R, Olive AJ, Hang S, Bernier J, Huh JR, Sassetti CM, Knipe DM, Gazzinelli RT, Fitzgerald KA. CNBP controls IL-12 gene transcription and Th1 immunity. J Exp Med. 2018 12 03; 215(12):3136-3150. PMID: 30442645.
    Citations: 14     Fields:    Translation:AnimalsCells
  26. Su Z, Dziedzic SA, Hu D, Barrett VJ, Broekema N, Li W, Qian L, Jia N, Ofengeim D, Najafov A, Zhu H, Knipe DM, Yuan J. ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner. Cell Death Differ. 2019 06; 26(6):1077-1088. PMID: 30341420.
    Citations: 4     Fields:    Translation:AnimalsCells
  27. Merkl PE, Orzalli MH, Knipe DM. Mechanisms of Host IFI16, PML, and Daxx Protein Restriction of Herpes Simplex Virus 1 Replication. J Virol. 2018 05 15; 92(10). PMID: 29491153.
    Citations: 32     Fields:    Translation:HumansCells
  28. Lee JS, Raja P, Pan D, Pesola JM, Coen DM, Knipe DM. CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection. mBio. 2018 02 06; 9(1). PMID: 29437926.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  29. Manivanh R, Mehrbach J, Knipe DM, Leib DA. Role of Herpes Simplex Virus 1 ?34.5 in the Regulation of IRF3 Signaling. J Virol. 2017 12 01; 91(23). PMID: 28904192.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  30. Hoyos-Bachiloglu R, Chou J, Sodroski CN, Beano A, Bainter W, Angelova M, Al Idrissi E, Habazi MK, Alghamdi HA, Almanjomi F, Al Shehri M, Elsidig N, Alaa Eldin M, Knipe DM, AlZahrani M, Geha RS. A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations. J Clin Invest. 2017 12 01; 127(12):4415-4420. PMID: 29106381.
    Citations: 31     Fields:    Translation:HumansCellsCTClinical Trials
  31. Diaz F, Gregory S, Nakashima H, Viapiano MS, Knipe DM. Intramuscular delivery of replication-defective herpes simplex virus gives antigen expression in muscle syncytia and improved protection against pathogenic HSV-2 strains. Virology. 2018 01 01; 513:129-135. PMID: 29069622.
    Citations: 7     Fields:    Translation:AnimalsCells
  32. Peng T, Chanthaphavong RS, Sun S, Trigilio JA, Phasouk K, Jin L, Layton ED, Li AZ, Correnti CE, De van der Schueren W, Vazquez J, O'Day DR, Glass IA, Knipe DM, Wald A, Corey L, Zhu J. Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation. J Exp Med. 2017 Aug 07; 214(8):2315-2329. PMID: 28663436.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  33. Knipe DM, Raja P, Lee J. Viral gene products actively promote latent infection by epigenetic silencing mechanisms. Curr Opin Virol. 2017 04; 23:68-74. PMID: 28415052.
    Citations: 9     Fields:    Translation:Cells
  34. Kurt-Jones EA, Orzalli MH, Knipe DM. Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease. Adv Anat Embryol Cell Biol. 2017; 223:49-75. PMID: 28528439.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  35. Zhao J, Zeng Y, Xu S, Chen J, Shen G, Yu C, Knipe D, Yuan W, Peng J, Xu W, Zhang C, Xia Z, Feng P. A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation. Cell Host Microbe. 2016 Dec 14; 20(6):770-784. PMID: 27866900.
    Citations: 51     Fields:    Translation:HumansCells
  36. Orzalli MH, Broekema NM, Knipe DM. Relative Contributions of Herpes Simplex Virus 1 ICP0 and vhs to Loss of Cellular IFI16 Vary in Different Human Cell Types. J Virol. 2016 09 15; 90(18):8351-9. PMID: 27412599.
    Citations: 43     Fields:    Translation:HumansCells
  37. Taylor TJ, Diaz F, Colgrove RC, Bernard KA, DeLuca NA, Whelan SPJ, Knipe DM. Production of immunogenic West Nile virus-like particles using a herpes simplex virus 1 recombinant vector. Virology. 2016 09; 496:186-193. PMID: 27336950.
    Citations: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  38. Christensen MH, Jensen SB, Miettinen JJ, Luecke S, Prabakaran T, Reinert LS, Mettenleiter T, Chen ZJ, Knipe DM, Sandri-Goldin RM, Enquist LW, Hartmann R, Mogensen TH, Rice SA, Nyman TA, Matikainen S, Paludan SR. HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. EMBO J. 2016 07 01; 35(13):1385-99. PMID: 27234299.
    Citations: 100     Fields:    Translation:HumansCells
  39. Raja P, Lee JS, Pan D, Pesola JM, Coen DM, Knipe DM. A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin. mBio. 2016 05 17; 7(3). PMID: 27190217.
    Citations: 24     Fields:    Translation:AnimalsCells
  40. Lee JS, Raja P, Knipe DM. Herpesviral ICP0 Protein Promotes Two Waves of Heterochromatin Removal on an Early Viral Promoter during Lytic Infection. mBio. 2016 Jan 12; 7(1):e02007-15. PMID: 26758183.
    Citations: 40     Fields:    Translation:HumansCells
  41. Diaz FM, Knipe DM. Protection from genital herpes disease, seroconversion and latent infection in a non-lethal murine genital infection model by immunization with an HSV-2 replication-defective mutant virus. Virology. 2016 Jan 15; 488:61-7. PMID: 26609935.
    Citations: 7     Fields:    Translation:AnimalsCells
  42. Colgrove RC, Liu X, Griffiths A, Raja P, Deluca NA, Newman RM, Coen DM, Knipe DM. History and genomic sequence analysis of the herpes simplex virus 1 KOS and KOS1.1 sub-strains. Virology. 2016 Jan; 487:215-21. PMID: 26547038.
    Citations: 17     Fields:    Translation:AnimalsCells
  43. Thomann S, Boscheinen JB, Vogel K, Knipe DM, DeLuca N, Gross S, Schuler-Thurner B, Schuster P, Schmidt B. Combined cytotoxic activity of an infectious, but non-replicative herpes simplex virus type 1 and plasmacytoid dendritic cells against tumour cells. Immunology. 2015 Oct; 146(2):327-38. PMID: 26194553.
    Citations: 8     Fields:    Translation:HumansCells
  44. Knipe DM, Raja P, Lee JS. Clues to mechanisms of herpesviral latent infection and potential cures. Proc Natl Acad Sci U S A. 2015 Sep 29; 112(39):11993-4. PMID: 26392531.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  45. Angelova M, Ortiz-Meoz RF, Walker S, Knipe DM. Inhibition of O-Linked N-Acetylglucosamine Transferase Reduces Replication of Herpes Simplex Virus and Human Cytomegalovirus. J Virol. 2015 Aug; 89(16):8474-83. PMID: 26041297.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  46. Lamers SL, Newman RM, Laeyendecker O, Tobian AA, Colgrove RC, Ray SC, Koelle DM, Cohen J, Knipe DM, Quinn TC. Global Diversity within and between Human Herpesvirus 1 and 2 Glycoproteins. J Virol. 2015 Aug; 89(16):8206-18. PMID: 26018161.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  47. Newman RM, Lamers SL, Weiner B, Ray SC, Colgrove RC, Diaz F, Jing L, Wang K, Saif S, Young S, Henn M, Laeyendecker O, Tobian AA, Cohen JI, Koelle DM, Quinn TC, Knipe DM. Genome Sequencing and Analysis of Geographically Diverse Clinical Isolates of Herpes Simplex Virus 2. J Virol. 2015 Aug; 89(16):8219-32. PMID: 26018166.
    Citations: 40     Fields:    Translation:HumansCells
  48. Oh HS, Traktman P, Knipe DM. Barrier-to-Autointegration Factor 1 (BAF/BANF1) Promotes Association of the SETD1A Histone Methyltransferase with Herpes Simplex Virus Immediate-Early Gene Promoters. mBio. 2015 May 26; 6(3):e00345-15. PMID: 26015494.
    Citations: 8     Fields:    Translation:HumansCells
  49. Knipe DM, Whelan SP. Rethinking the Response to Emerging Microbes: Vaccines and Therapeutics in the Ebola Era--a Conference at Harvard Medical School. J Virol. 2015 Aug; 89(15):7446-8. PMID: 25995250.
    Citations: 3     Fields:    Translation:HumansCells
  50. Suk H, Knipe DM. Proteomic analysis of the herpes simplex virus 1 virion protein 16 transactivator protein in infected cells. Proteomics. 2015 Jun; 15(12):1957-67. PMID: 25809282.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  51. Orzalli MH, Broekema NM, Diner BA, Hancks DC, Elde NC, Cristea IM, Knipe DM. cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):E1773-81. PMID: 25831530.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  52. Knipe DM. Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunity. Virology. 2015 May; 479-480:153-9. PMID: 25742715.
    Citations: 50     Fields:    Translation:HumansCells
  53. Hendricks GL, Velazquez L, Pham S, Qaisar N, Delaney JC, Viswanathan K, Albers L, Comolli JC, Shriver Z, Knipe DM, Kurt-Jones EA, Fygenson DK, Trevejo JM, Wang JP, Finberg RW. Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses. Antiviral Res. 2015 Apr; 116:34-44. PMID: 25637710.
    Citations: 7     Fields:    Translation:AnimalsCells
  54. Deng Z, Kim ET, Vladimirova O, Dheekollu J, Wang Z, Newhart A, Liu D, Myers JL, Hensley SE, Moffat J, Janicki SM, Fraser NW, Knipe DM, Weitzman MD, Lieberman PM. HSV-1 remodels host telomeres to facilitate viral replication. Cell Rep. 2014 Dec 24; 9(6):2263-78. PMID: 25497088.
    Citations: 17     Fields:    Translation:HumansCells
  55. Hill JM, Quenelle DC, Cardin RD, Vogel JL, Clement C, Bravo FJ, Foster TP, Bosch-Marce M, Raja P, Lee JS, Bernstein DI, Krause PR, Knipe DM, Kristie TM. Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes. Sci Transl Med. 2014 Dec 03; 6(265):265ra169. PMID: 25473037.
    Citations: 47     Fields:    Translation:AnimalsCells
  56. Conwell SE, White AE, Harper JW, Knipe DM. Identification of TRIM27 as a novel degradation target of herpes simplex virus 1 ICP0. J Virol. 2015 Jan; 89(1):220-9. PMID: 25320289.
    Citations: 24     Fields:    Translation:HumansCells
  57. Thompson MR, Sharma S, Atianand M, Jensen SB, Carpenter S, Knipe DM, Fitzgerald KA, Kurt-Jones EA. Interferon ?-inducible protein (IFI) 16 transcriptionally regulates type i interferons and other interferon-stimulated genes and controls the interferon response to both DNA and RNA viruses. J Biol Chem. 2014 Aug 22; 289(34):23568-81. PMID: 25002588.
    Citations: 61     Fields:    Translation:HumansCells
  58. Yan Z, Bryant KF, Gregory SM, Angelova M, Dreyfus DH, Zhao XZ, Coen DM, Burke TR, Knipe DM. HIV integrase inhibitors block replication of alpha-, beta-, and gammaherpesviruses. mBio. 2014 Jul 01; 5(4):e01318-14. PMID: 24987091.
    Citations: 16     Fields:    Translation:HumansCells
  59. Orzalli MH, Knipe DM. Cellular sensing of viral DNA and viral evasion mechanisms. Annu Rev Microbiol. 2014; 68:477-92. PMID: 25002095.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  60. Bonham KS, Orzalli MH, Hayashi K, Wolf AI, Glanemann C, Weninger W, Iwasaki A, Knipe DM, Kagan JC. A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction. Cell. 2014 Feb 13; 156(4):705-16. PMID: 24529375.
    Citations: 106     Fields:    Translation:AnimalsCells
  61. Oh HS, Bryant KF, Nieland TJ, Mazumder A, Bagul M, Bathe M, Root DE, Knipe DM. A targeted RNA interference screen reveals novel epigenetic factors that regulate herpesviral gene expression. mBio. 2014 Feb 04; 5(1):e01086-13. PMID: 24496796.
    Citations: 18     Fields:    Translation:HumansCells
  62. Knipe DM, Corey L, Cohen JI, Deal CD. Summary and recommendations from a National Institute of Allergy and Infectious Diseases (NIAID) workshop on "Next Generation Herpes Simplex Virus Vaccines". Vaccine. 2014 Mar 20; 32(14):1561-2. PMID: 24480025.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  63. Colgrove R, Diaz F, Newman R, Saif S, Shea T, Young S, Henn M, Knipe DM. Genomic sequences of a low passage herpes simplex virus 2 clinical isolate and its plaque-purified derivative strain. Virology. 2014 Feb; 450-451:140-5. PMID: 24503076.
    Citations: 22     Fields:    Translation:HumansCells
  64. Orzalli MH, Conwell SE, Berrios C, DeCaprio JA, Knipe DM. Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4492-501. PMID: 24198334.
    Citations: 95     Fields:    Translation:HumansCells
  65. Sen J, Liu X, Roller R, Knipe DM. Herpes simplex virus US3 tegument protein inhibits Toll-like receptor 2 signaling at or before TRAF6 ubiquitination. Virology. 2013 May 10; 439(2):65-73. PMID: 23478027.
    Citations: 30     Fields:    Translation:HumansCells
  66. Cliffe AR, Coen DM, Knipe DM. Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection. mBio. 2013 Jan 15; 4(1). PMID: 23322639.
    Citations: 46     Fields:    Translation:AnimalsCells
  67. Knipe DM, Lieberman PM, Jung JU, McBride AA, Morris KV, Ott M, Margolis D, Nieto A, Nevels M, Parks RJ, Kristie TM. Snapshots: chromatin control of viral infection. Virology. 2013 Jan 05; 435(1):141-56. PMID: 23217624.
    Citations: 86     Fields:    Translation:HumansCells
  68. Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N. Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nat Immunol. 2013 Feb; 14(2):179-85. PMID: 23263557.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  69. Soberman RJ, MacKay CR, Vaine CA, Ryan GB, Cerny AM, Thompson MR, Nikolic B, Primo V, Christmas P, Sheiffele P, Aronov L, Knipe DM, Kurt-Jones EA. CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2. PLoS One. 2012; 7(10):e47740. PMID: 23082204.
    Citations: 14     Fields:    Translation:AnimalsCells
  70. Orzalli MH, DeLuca NA, Knipe DM. Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):E3008-17. PMID: 23027953.
    Citations: 240     Fields:    Translation:HumansCells
  71. Larson AM, Oh HS, Knipe DM, Klibanov AM. Decreasing herpes simplex viral infectivity in solution by surface-immobilized and suspended N,N-dodecyl,methyl-polyethylenimine. Pharm Res. 2013 Jan; 30(1):25-31. PMID: 22798261.
    Citations: 4     Fields:    Translation:HumansCells
  72. Bryant KF, Yan Z, Dreyfus DH, Knipe DM. Identification of a divalent metal cation binding site in herpes simplex virus 1 (HSV-1) ICP8 required for HSV replication. J Virol. 2012 Jun; 86(12):6825-34. PMID: 22491472.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  73. Barczak AK, Gomez JE, Kaufmann BB, Hinson ER, Cosimi L, Borowsky ML, Onderdonk AB, Stanley SA, Kaur D, Bryant KF, Knipe DM, Sloutsky A, Hung DT. RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6217-22. PMID: 22474362.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  74. Silva L, Oh HS, Chang L, Yan Z, Triezenberg SJ, Knipe DM. Roles of the nuclear lamina in stable nuclear association and assembly of a herpesviral transactivator complex on viral immediate-early genes. mBio. 2012; 3(1). PMID: 22251972.
    Citations: 13     Fields:    Translation:AnimalsCells
  75. Wang JP, Bowen GN, Zhou S, Cerny A, Zacharia A, Knipe DM, Finberg RW, Kurt-Jones EA. Role of specific innate immune responses in herpes simplex virus infection of the central nervous system. J Virol. 2012 Feb; 86(4):2273-81. PMID: 22171256.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  76. Strang BL, Boulant S, Chang L, Knipe DM, Kirchhausen T, Coen DM. Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis. J Virol. 2012 Feb; 86(4):2089-95. PMID: 22156516.
    Citations: 29     Fields:    Translation:HumansCells
  77. Kramer MF, Jurak I, Pesola JM, Boissel S, Knipe DM, Coen DM. Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia. Virology. 2011 Sep 01; 417(2):239-47. PMID: 21782205.
    Citations: 39     Fields:    Translation:AnimalsCells
  78. Rao P, Pham HT, Kulkarni A, Yang Y, Liu X, Knipe DM, Cresswell P, Yuan W. Herpes simplex virus 1 glycoprotein B and US3 collaborate to inhibit CD1d antigen presentation and NKT cell function. J Virol. 2011 Aug; 85(16):8093-104. PMID: 21653669.
    Citations: 36     Fields:    Translation:HumansCells
  79. Chang L, Godinez WJ, Kim IH, Tektonidis M, de Lanerolle P, Eils R, Rohr K, Knipe DM. Herpesviral replication compartments move and coalesce at nuclear speckles to enhance export of viral late mRNA. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):E136-44. PMID: 21555562.
    Citations: 50     Fields:    Translation:AnimalsCells
  80. Dudek TE, Torres-Lopez E, Crumpacker C, Knipe DM. Evidence for differences in immunologic and pathogenesis properties of herpes simplex virus 2 strains from the United States and South Africa. J Infect Dis. 2011 May 15; 203(10):1434-41. PMID: 21498376.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  81. Bryant KF, Colgrove RC, Knipe DM. Cellular SNF2H chromatin-remodeling factor promotes herpes simplex virus 1 immediate-early gene expression and replication. mBio. 2011 Jan 18; 2(1):e00330-10. PMID: 21249171.
    Citations: 12     Fields:    Translation:HumansCells
  82. van Lint AL, Murawski MR, Goodbody RE, Severa M, Fitzgerald KA, Finberg RW, Knipe DM, Kurt-Jones EA. Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling. J Virol. 2010 Oct; 84(20):10802-11. PMID: 20686034.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  83. Zhou S, Cerny AM, Bowen G, Chan M, Knipe DM, Kurt-Jones EA, Finberg RW. Discovery of a novel TLR2 signaling inhibitor with anti-viral activity. Antiviral Res. 2010 Sep; 87(3):295-306. PMID: 20603154.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  84. Jurak I, Kramer MF, Mellor JC, van Lint AL, Roth FP, Knipe DM, Coen DM. Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2. J Virol. 2010 May; 84(9):4659-72. PMID: 20181707.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  85. Reszka NJ, Dudek T, Knipe DM. Construction and properties of a herpes simplex virus 2 dl5-29 vaccine candidate strain encoding an HSV-1 virion host shutoff protein. Vaccine. 2010 Mar 24; 28(15):2754-62. PMID: 20117270.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  86. Reszka N, Zhou C, Song B, Sodroski JG, Knipe DM. Simian TRIM5alpha proteins reduce replication of herpes simplex virus. Virology. 2010 Mar 15; 398(2):243-50. PMID: 20060996.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  87. Hancock MH, Cliffe AR, Knipe DM, Smiley JR. Herpes simplex virus VP16, but not ICP0, is required to reduce histone occupancy and enhance histone acetylation on viral genomes in U2OS osteosarcoma cells. J Virol. 2010 Feb; 84(3):1366-75. PMID: 19939931.
    Citations: 30     Fields:    Translation:HumansCells
  88. Johnson KE, Knipe DM. Herpes simplex virus-1 infection causes the secretion of a type I interferon-antagonizing protein and inhibits signaling at or before Jak-1 activation. Virology. 2010 Jan 05; 396(1):21-9. PMID: 19879619.
    Citations: 28     Fields:    Translation:AnimalsCells
  89. Hoshino Y, Pesnicak L, Dowdell KC, Burbelo PD, Knipe DM, Straus SE, Cohen JI. Protection from herpes simplex virus (HSV)-2 infection with replication-defective HSV-2 or glycoprotein D2 vaccines in HSV-1-seropositive and HSV-1-seronegative guinea pigs. J Infect Dis. 2009 Oct 01; 200(7):1088-95. PMID: 19702506.
    Citations: 35     Fields:    Translation:AnimalsCells
  90. Cliffe AR, Garber DA, Knipe DM. Transcription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters. J Virol. 2009 Aug; 83(16):8182-90. PMID: 19515781.