Harvard Catalyst Profiles

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David Mahan Knipe, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01AI106934 (KNIPE, DAVID M.) Apr 15, 2014 - Jul 31, 2022
    NIH/NIAID
    Nuclear Sensing of Herpesviral DNA
    Role: Principal Investigator
  2. R56DE023909 (KNIPE, DAVID M) Sep 21, 2013 - Aug 31, 2015
    NIH/NIDCR
    Epigenetic Regulation of HSV Infection of Oral Cells
    Role: Principal Investigator
  3. P01AI098681 (COEN, DONALD M) Jul 2, 2013 - Jun 30, 2018
    NIH/NIAID
    Viral And host mechanisms that tilt the HSV lytic/latent balance
    Role: Co-Principal Investigator
  4. R01AI099081 (KNIPE, DAVID M) Feb 1, 2012 - Jan 31, 2017
    NIH/NIAID
    Chromatin and Herpes Simplex Virus Latency
    Role: Principal Investigator
  5. R01AI057552 (KNIPE, DAVID M) Dec 1, 2003 - Jun 30, 2015
    NIH/NIAID
    International Herpes Vaccine Project
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Patel CD, Backes IM, Taylor SA, Jiang Y, Marchant A, Pesola JM, Coen DM, Knipe DM, Ackerman ME, Leib DA. Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity. Sci Transl Med. 2019 Apr 10; 11(487). PMID: 30971454.
    Citations:    
  2. Pan D, Li G, Morris-Love J, Qi S, Feng L, Mertens ME, Jurak I, Knipe DM, Coen DM. Herpes Simplex Virus 1 Lytic Infection Blocks MicroRNA (miRNA) Biogenesis at the Stage of Nuclear Export of Pre-miRNAs. MBio. 2019 02 12; 10(1). PMID: 30755517.
    Citations:    
  3. Merkl PE, Knipe DM. Role for a Filamentous Nuclear Assembly of IFI16, DNA, and Host Factors in Restriction of Herpesviral Infection. MBio. 2019 01 22; 10(1). PMID: 30670617.
    Citations:    Fields:    
  4. Boscheinen JB, Thomann S, Knipe DM, DeLuca N, Schuler-Thurner B, Gross S, Dörrie J, Schaft N, Bach C, Rohrhofer A, Werner-Klein M, Schmidt B, Schuster P. Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA. Front Immunol. 2019; 10:2. PMID: 30723467.
    Citations:    
  5. Zmasek CM, Knipe DM, Pellett PE, Scheuermann RH. Classification of human Herpesviridae proteins using Domain-architecture Aware Inference of Orthologs (DAIO). Virology. 2019 Mar; 529:29-42. PMID: 30660046.
    Citations:    Fields:    
  6. Cabral JM, Oh HS, Knipe DM. ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress. Elife. 2018 11 22; 7. PMID: 30465651.
    Citations:    Fields:    
  7. Chen Y, Sharma S, Assis PA, Jiang Z, Elling R, Olive AJ, Hang S, Bernier J, Huh JR, Sassetti CM, Knipe DM, Gazzinelli RT, Fitzgerald KA. CNBP controls IL-12 gene transcription and Th1 immunity. J Exp Med. 2018 Dec 03; 215(12):3136-3150. PMID: 30442645.
    Citations:    Fields:    
  8. Su Z, Dziedzic SA, Hu D, Barrett VJ, Broekema N, Li W, Qian L, Jia N, Ofengeim D, Najafov A, Zhu H, Knipe DM, Yuan J. ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner. Cell Death Differ. 2019 Jun; 26(6):1077-1088. PMID: 30341420.
    Citations:    Fields:    
  9. Merkl PE, Orzalli MH, Knipe DM. Mechanisms of Host IFI16, PML, and Daxx Protein Restriction of Herpes Simplex Virus 1 Replication. J Virol. 2018 05 15; 92(10). PMID: 29491153.
    Citations: 1     Fields:    Translation:HumansCells
  10. Lee JS, Raja P, Pan D, Pesola JM, Coen DM, Knipe DM. CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection. MBio. 2018 02 06; 9(1). PMID: 29437926.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  11. Manivanh R, Mehrbach J, Knipe DM, Leib DA. Role of Herpes Simplex Virus 1 ?34.5 in the Regulation of IRF3 Signaling. J Virol. 2017 12 01; 91(23). PMID: 28904192.
    Citations:    Fields:    Translation:HumansAnimalsCells
  12. Hoyos-Bachiloglu R, Chou J, Sodroski CN, Beano A, Bainter W, Angelova M, Al Idrissi E, Habazi MK, Alghamdi HA, Almanjomi F, Al Shehri M, Elsidig N, Alaa Eldin M, Knipe DM, AlZahrani M, Geha RS. A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations. J Clin Invest. 2017 12 01; 127(12):4415-4420. PMID: 29106381.
    Citations: 3     Fields:    
  13. Diaz F, Gregory S, Nakashima H, Viapiano MS, Knipe DM. Intramuscular delivery of replication-defective herpes simplex virus gives antigen expression in muscle syncytia and improved protection against pathogenic HSV-2 strains. Virology. 2018 01 01; 513:129-135. PMID: 29069622.
    Citations:    Fields:    Translation:AnimalsCells
  14. Peng T, Chanthaphavong RS, Sun S, Trigilio JA, Phasouk K, Jin L, Layton ED, Li AZ, Correnti CE, De van der Schueren W, Vazquez J, O'Day DR, Glass IA, Knipe DM, Wald A, Corey L, Zhu J. Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation. J Exp Med. 2017 Aug 07; 214(8):2315-2329. PMID: 28663436.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  15. Knipe DM, Raja P, Lee J. Viral gene products actively promote latent infection by epigenetic silencing mechanisms. Curr Opin Virol. 2017 04; 23:68-74. PMID: 28415052.
    Citations: 4     Fields:    Translation:Cells
  16. Kurt-Jones EA, Orzalli MH, Knipe DM. Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease. Adv Anat Embryol Cell Biol. 2017; 223:49-75. PMID: 28528439.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  17. Zhao J, Zeng Y, Xu S, Chen J, Shen G, Yu C, Knipe D, Yuan W, Peng J, Xu W, Zhang C, Xia Z, Feng P. A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation. Cell Host Microbe. 2016 Dec 14; 20(6):770-784. PMID: 27866900.
    Citations: 9     Fields:    Translation:HumansCells
  18. Orzalli MH, Broekema NM, Knipe DM. Relative Contributions of Herpes Simplex Virus 1 ICP0 and vhs to Loss of Cellular IFI16 Vary in Different Human Cell Types. J Virol. 2016 09 15; 90(18):8351-9. PMID: 27412599.
    Citations: 8     Fields:    Translation:HumansCells
  19. Taylor TJ, Diaz F, Colgrove RC, Bernard KA, DeLuca NA, Whelan SPJ, Knipe DM. Production of immunogenic West Nile virus-like particles using a herpes simplex virus 1 recombinant vector. Virology. 2016 09; 496:186-193. PMID: 27336950.
    Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  20. Christensen MH, Jensen SB, Miettinen JJ, Luecke S, Prabakaran T, Reinert LS, Mettenleiter T, Chen ZJ, Knipe DM, Sandri-Goldin RM, Enquist LW, Hartmann R, Mogensen TH, Rice SA, Nyman TA, Matikainen S, Paludan SR. HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. EMBO J. 2016 07 01; 35(13):1385-99. PMID: 27234299.
    Citations: 14     Fields:    Translation:HumansCells
  21. Raja P, Lee JS, Pan D, Pesola JM, Coen DM, Knipe DM. A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin. MBio. 2016 05 17; 7(3). PMID: 27190217.
    Citations: 10     Fields:    Translation:AnimalsCells
  22. Lee JS, Raja P, Knipe DM. Herpesviral ICP0 Protein Promotes Two Waves of Heterochromatin Removal on an Early Viral Promoter during Lytic Infection. MBio. 2016 Jan 12; 7(1):e02007-15. PMID: 26758183.
    Citations: 14     Fields:    Translation:HumansCells
  23. Diaz FM, Knipe DM. Protection from genital herpes disease, seroconversion and latent infection in a non-lethal murine genital infection model by immunization with an HSV-2 replication-defective mutant virus. Virology. 2016 Jan 15; 488:61-7. PMID: 26609935.
    Citations: 2     Fields:    Translation:AnimalsCells
  24. Colgrove RC, Liu X, Griffiths A, Raja P, Deluca NA, Newman RM, Coen DM, Knipe DM. History and genomic sequence analysis of the herpes simplex virus 1 KOS and KOS1.1 sub-strains. Virology. 2016 Jan; 487:215-21. PMID: 26547038.
    Citations: 6     Fields:    Translation:AnimalsCells
  25. Thomann S, Boscheinen JB, Vogel K, Knipe DM, DeLuca N, Gross S, Schuler-Thurner B, Schuster P, Schmidt B. Combined cytotoxic activity of an infectious, but non-replicative herpes simplex virus type 1 and plasmacytoid dendritic cells against tumour cells. Immunology. 2015 Oct; 146(2):327-38. PMID: 26194553.
    Citations: 2     Fields:    Translation:HumansCells
  26. Knipe DM, Raja P, Lee JS. Clues to mechanisms of herpesviral latent infection and potential cures. Proc Natl Acad Sci U S A. 2015 Sep 29; 112(39):11993-4. PMID: 26392531.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  27. Angelova M, Ortiz-Meoz RF, Walker S, Knipe DM. Inhibition of O-Linked N-Acetylglucosamine Transferase Reduces Replication of Herpes Simplex Virus and Human Cytomegalovirus. J Virol. 2015 Aug; 89(16):8474-83. PMID: 26041297.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  28. Lamers SL, Newman RM, Laeyendecker O, Tobian AA, Colgrove RC, Ray SC, Koelle DM, Cohen J, Knipe DM, Quinn TC. Global Diversity within and between Human Herpesvirus 1 and 2 Glycoproteins. J Virol. 2015 Aug; 89(16):8206-18. PMID: 26018161.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  29. Newman RM, Lamers SL, Weiner B, Ray SC, Colgrove RC, Diaz F, Jing L, Wang K, Saif S, Young S, Henn M, Laeyendecker O, Tobian AA, Cohen JI, Koelle DM, Quinn TC, Knipe DM. Genome Sequencing and Analysis of Geographically Diverse Clinical Isolates of Herpes Simplex Virus 2. J Virol. 2015 Aug; 89(16):8219-32. PMID: 26018166.
    Citations: 17     Fields:    Translation:HumansCells
  30. Oh HS, Traktman P, Knipe DM. Barrier-to-Autointegration Factor 1 (BAF/BANF1) Promotes Association of the SETD1A Histone Methyltransferase with Herpes Simplex Virus Immediate-Early Gene Promoters. MBio. 2015 May 26; 6(3):e00345-15. PMID: 26015494.
    Citations: 2     Fields:    Translation:HumansCells
  31. Knipe DM, Whelan SP. Rethinking the Response to Emerging Microbes: Vaccines and Therapeutics in the Ebola Era--a Conference at Harvard Medical School. J Virol. 2015 Aug; 89(15):7446-8. PMID: 25995250.
    Citations: 2     Fields:    Translation:HumansCells
  32. Suk H, Knipe DM. Proteomic analysis of the herpes simplex virus 1 virion protein 16 transactivator protein in infected cells. Proteomics. 2015 Jun; 15(12):1957-67. PMID: 25809282.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  33. Orzalli MH, Broekema NM, Diner BA, Hancks DC, Elde NC, Cristea IM, Knipe DM. cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):E1773-81. PMID: 25831530.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  34. Knipe DM. Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunity. Virology. 2015 May; 479-480:153-9. PMID: 25742715.
    Citations: 17     Fields:    Translation:HumansCells
  35. Hendricks GL, Velazquez L, Pham S, Qaisar N, Delaney JC, Viswanathan K, Albers L, Comolli JC, Shriver Z, Knipe DM, Kurt-Jones EA, Fygenson DK, Trevejo JM, Wang JP, Finberg RW. Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses. Antiviral Res. 2015 Apr; 116:34-44. PMID: 25637710.
    Citations: 2     Fields:    Translation:AnimalsCells
  36. Deng Z, Kim ET, Vladimirova O, Dheekollu J, Wang Z, Newhart A, Liu D, Myers JL, Hensley SE, Moffat J, Janicki SM, Fraser NW, Knipe DM, Weitzman MD, Lieberman PM. HSV-1 remodels host telomeres to facilitate viral replication. Cell Rep. 2014 Dec 24; 9(6):2263-78. PMID: 25497088.
    Citations: 8     Fields:    Translation:HumansCells
  37. Hill JM, Quenelle DC, Cardin RD, Vogel JL, Clement C, Bravo FJ, Foster TP, Bosch-Marce M, Raja P, Lee JS, Bernstein DI, Krause PR, Knipe DM, Kristie TM. Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes. Sci Transl Med. 2014 Dec 03; 6(265):265ra169. PMID: 25473037.
    Citations: 23     Fields:    Translation:AnimalsCells
  38. Conwell SE, White AE, Harper JW, Knipe DM. Identification of TRIM27 as a novel degradation target of herpes simplex virus 1 ICP0. J Virol. 2015 Jan; 89(1):220-9. PMID: 25320289.
    Citations: 8     Fields:    Translation:HumansCells
  39. Thompson MR, Sharma S, Atianand M, Jensen SB, Carpenter S, Knipe DM, Fitzgerald KA, Kurt-Jones EA. Interferon ?-inducible protein (IFI) 16 transcriptionally regulates type i interferons and other interferon-stimulated genes and controls the interferon response to both DNA and RNA viruses. J Biol Chem. 2014 Aug 22; 289(34):23568-81. PMID: 25002588.
    Citations: 26     Fields:    Translation:HumansCells
  40. Yan Z, Bryant KF, Gregory SM, Angelova M, Dreyfus DH, Zhao XZ, Coen DM, Burke TR, Knipe DM. HIV integrase inhibitors block replication of alpha-, beta-, and gammaherpesviruses. MBio. 2014 Jul 01; 5(4):e01318-14. PMID: 24987091.
    Citations: 8     Fields:    Translation:HumansCells
  41. Orzalli MH, Knipe DM. Cellular sensing of viral DNA and viral evasion mechanisms. Annu Rev Microbiol. 2014; 68:477-92. PMID: 25002095.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  42. Bonham KS, Orzalli MH, Hayashi K, Wolf AI, Glanemann C, Weninger W, Iwasaki A, Knipe DM, Kagan JC. A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction. Cell. 2014 Feb 13; 156(4):705-16. PMID: 24529375.
    Citations: 57     Fields:    Translation:AnimalsCells
  43. Oh HS, Bryant KF, Nieland TJ, Mazumder A, Bagul M, Bathe M, Root DE, Knipe DM. A targeted RNA interference screen reveals novel epigenetic factors that regulate herpesviral gene expression. MBio. 2014 Feb 04; 5(1):e01086-13. PMID: 24496796.
    Citations: 14     Fields:    Translation:HumansCells
  44. Knipe DM, Corey L, Cohen JI, Deal CD. Summary and recommendations from a National Institute of Allergy and Infectious Diseases (NIAID) workshop on "Next Generation Herpes Simplex Virus Vaccines". Vaccine. 2014 Mar 20; 32(14):1561-2. PMID: 24480025.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  45. Colgrove R, Diaz F, Newman R, Saif S, Shea T, Young S, Henn M, Knipe DM. Genomic sequences of a low passage herpes simplex virus 2 clinical isolate and its plaque-purified derivative strain. Virology. 2014 Feb; 450-451:140-5. PMID: 24503076.
    Citations: 11     Fields:    Translation:HumansCells
  46. Orzalli MH, Conwell SE, Berrios C, DeCaprio JA, Knipe DM. Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):E4492-501. PMID: 24198334.
    Citations: 53     Fields:    Translation:HumansCells
  47. Sen J, Liu X, Roller R, Knipe DM. Herpes simplex virus US3 tegument protein inhibits Toll-like receptor 2 signaling at or before TRAF6 ubiquitination. Virology. 2013 May 10; 439(2):65-73. PMID: 23478027.
    Citations: 14     Fields:    Translation:HumansCells
  48. Cliffe AR, Coen DM, Knipe DM. Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection. MBio. 2013 Jan 15; 4(1). PMID: 23322639.
    Citations: 28     Fields:    Translation:AnimalsCells
  49. Knipe DM, Lieberman PM, Jung JU, McBride AA, Morris KV, Ott M, Margolis D, Nieto A, Nevels M, Parks RJ, Kristie TM. Snapshots: chromatin control of viral infection. Virology. 2013 Jan 05; 435(1):141-56. PMID: 23217624.
    Citations: 56     Fields:    Translation:HumansCells
  50. Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N. Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nat Immunol. 2013 Feb; 14(2):179-85. PMID: 23263557.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  51. Soberman RJ, MacKay CR, Vaine CA, Ryan GB, Cerny AM, Thompson MR, Nikolic B, Primo V, Christmas P, Sheiffele P, Aronov L, Knipe DM, Kurt-Jones EA. CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2. PLoS One. 2012; 7(10):e47740. PMID: 23082204.
    Citations: 8     Fields:    Translation:AnimalsCells
  52. Orzalli MH, DeLuca NA, Knipe DM. Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):E3008-17. PMID: 23027953.
    Citations: 127     Fields:    Translation:HumansCells
  53. Larson AM, Oh HS, Knipe DM, Klibanov AM. Decreasing herpes simplex viral infectivity in solution by surface-immobilized and suspended N,N-dodecyl,methyl-polyethylenimine. Pharm Res. 2013 Jan; 30(1):25-31. PMID: 22798261.
    Citations:    Fields:    Translation:HumansCells
  54. Bryant KF, Yan Z, Dreyfus DH, Knipe DM. Identification of a divalent metal cation binding site in herpes simplex virus 1 (HSV-1) ICP8 required for HSV replication. J Virol. 2012 Jun; 86(12):6825-34. PMID: 22491472.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  55. Barczak AK, Gomez JE, Kaufmann BB, Hinson ER, Cosimi L, Borowsky ML, Onderdonk AB, Stanley SA, Kaur D, Bryant KF, Knipe DM, Sloutsky A, Hung DT. RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6217-22. PMID: 22474362.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  56. Silva L, Oh HS, Chang L, Yan Z, Triezenberg SJ, Knipe DM. Roles of the nuclear lamina in stable nuclear association and assembly of a herpesviral transactivator complex on viral immediate-early genes. MBio. 2012; 3(1). PMID: 22251972.
    Citations: 6     Fields:    Translation:AnimalsCells
  57. Wang JP, Bowen GN, Zhou S, Cerny A, Zacharia A, Knipe DM, Finberg RW, Kurt-Jones EA. Role of specific innate immune responses in herpes simplex virus infection of the central nervous system. J Virol. 2012 Feb; 86(4):2273-81. PMID: 22171256.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  58. Strang BL, Boulant S, Chang L, Knipe DM, Kirchhausen T, Coen DM. Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis. J Virol. 2012 Feb; 86(4):2089-95. PMID: 22156516.
    Citations: 17     Fields:    Translation:HumansCells
  59. Kramer MF, Jurak I, Pesola JM, Boissel S, Knipe DM, Coen DM. Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia. Virology. 2011 Sep 01; 417(2):239-47. PMID: 21782205.
    Citations: 25     Fields:    Translation:AnimalsCells
  60. Rao P, Pham HT, Kulkarni A, Yang Y, Liu X, Knipe DM, Cresswell P, Yuan W. Herpes simplex virus 1 glycoprotein B and US3 collaborate to inhibit CD1d antigen presentation and NKT cell function. J Virol. 2011 Aug; 85(16):8093-104. PMID: 21653669.
    Citations: 25     Fields:    Translation:HumansCells
  61. Chang L, Godinez WJ, Kim IH, Tektonidis M, de Lanerolle P, Eils R, Rohr K, Knipe DM. Herpesviral replication compartments move and coalesce at nuclear speckles to enhance export of viral late mRNA. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):E136-44. PMID: 21555562.
    Citations: 26     Fields:    Translation:AnimalsCells
  62. Dudek TE, Torres-Lopez E, Crumpacker C, Knipe DM. Evidence for differences in immunologic and pathogenesis properties of herpes simplex virus 2 strains from the United States and South Africa. J Infect Dis. 2011 May 15; 203(10):1434-41. PMID: 21498376.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  63. Bryant KF, Colgrove RC, Knipe DM. Cellular SNF2H chromatin-remodeling factor promotes herpes simplex virus 1 immediate-early gene expression and replication. MBio. 2011 Jan 18; 2(1):e00330-10. PMID: 21249171.
    Citations: 11     Fields:    Translation:HumansCells
  64. van Lint AL, Murawski MR, Goodbody RE, Severa M, Fitzgerald KA, Finberg RW, Knipe DM, Kurt-Jones EA. Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling. J Virol. 2010 Oct; 84(20):10802-11. PMID: 20686034.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  65. Zhou S, Cerny AM, Bowen G, Chan M, Knipe DM, Kurt-Jones EA, Finberg RW. Discovery of a novel TLR2 signaling inhibitor with anti-viral activity. Antiviral Res. 2010 Sep; 87(3):295-306. PMID: 20603154.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  66. Jurak I, Kramer MF, Mellor JC, van Lint AL, Roth FP, Knipe DM, Coen DM. Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2. J Virol. 2010 May; 84(9):4659-72. PMID: 20181707.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  67. Reszka NJ, Dudek T, Knipe DM. Construction and properties of a herpes simplex virus 2 dl5-29 vaccine candidate strain encoding an HSV-1 virion host shutoff protein. Vaccine. 2010 Mar 24; 28(15):2754-62. PMID: 20117270.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  68. Reszka N, Zhou C, Song B, Sodroski JG, Knipe DM. Simian TRIM5alpha proteins reduce replication of herpes simplex virus. Virology. 2010 Mar 15; 398(2):243-50. PMID: 20060996.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  69. Hancock MH, Cliffe AR, Knipe DM, Smiley JR. Herpes simplex virus VP16, but not ICP0, is required to reduce histone occupancy and enhance histone acetylation on viral genomes in U2OS osteosarcoma cells. J Virol. 2010 Feb; 84(3):1366-75. PMID: 19939931.
    Citations: 20     Fields:    Translation:HumansCells
  70. Johnson KE, Knipe DM. Herpes simplex virus-1 infection causes the secretion of a type I interferon-antagonizing protein and inhibits signaling at or before Jak-1 activation. Virology. 2010 Jan 05; 396(1):21-9. PMID: 19879619.
    Citations: 16     Fields:    Translation:AnimalsCells
  71. Hoshino Y, Pesnicak L, Dowdell KC, Burbelo PD, Knipe DM, Straus SE, Cohen JI. Protection from herpes simplex virus (HSV)-2 infection with replication-defective HSV-2 or glycoprotein D2 vaccines in HSV-1-seropositive and HSV-1-seronegative guinea pigs. J Infect Dis. 2009 Oct 01; 200(7):1088-95. PMID: 19702506.
    Citations: 28     Fields:    Translation:AnimalsCells
  72. Cliffe AR, Garber DA, Knipe DM. Transcription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters. J Virol. 2009 Aug; 83(16):8182-90. PMID: 19515781.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  73. Liu X, Broberg E, Watanabe D, Dudek T, Deluca N, Knipe DM. Genetic engineering of a modified herpes simplex virus 1 vaccine vector. Vaccine. 2009 May 11; 27(21):2760-7. PMID: 19428888.
    Citations: 6     Fields:    Translation:AnimalsCells
  74. Hamirally S, Kamil JP, Ndassa-Colday YM, Lin AJ, Jahng WJ, Baek MC, Noton S, Silva LA, Simpson-Holley M, Knipe DM, Golan DE, Marto JA, Coen DM. Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress. PLoS Pathog. 2009 Jan; 5(1):e1000275. PMID: 19165338.
    Citations: 83     Fields:    Translation:HumansCells
  75. Taylor TJ, Knipe DM. The use of green fluorescent fusion proteins to monitor herpes simplex virus replication. Methods Mol Biol. 2009; 515:239-48. PMID: 19378129.
    Citations: 2     Fields:    Translation:AnimalsCells
  76. Brockman MA, Knipe DM. Herpes simplex virus as a tool to define the role of complement in the immune response to peripheral infection. Vaccine. 2008 Dec 30; 26 Suppl 8:I94-9. PMID: 19388172.
    Citations: 2     Fields:    Translation:HumansCells
  77. Cliffe AR, Knipe DM. Herpes simplex virus ICP0 promotes both histone removal and acetylation on viral DNA during lytic infection. J Virol. 2008 Dec; 82(24):12030-8. PMID: 18842720.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  78. Liu X, Fitzgerald K, Kurt-Jones E, Finberg R, Knipe DM. Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein. Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32):11335-9. PMID: 18682563.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  79. Hoshino Y, Pesnicak L, Dowdell KC, Lacayo J, Dudek T, Knipe DM, Straus SE, Cohen JI. Comparison of immunogenicity and protective efficacy of genital herpes vaccine candidates herpes simplex virus 2 dl5-29 and dl5-29-41L in mice and guinea pigs. Vaccine. 2008 Jul 29; 26(32):4034-40. PMID: 18565628.
    Citations: 25     Fields:    Translation:AnimalsCells
  80. Silva L, Cliffe A, Chang L, Knipe DM. Role for A-type lamins in herpesviral DNA targeting and heterochromatin modulation. PLoS Pathog. 2008 May 23; 4(5):e1000071. PMID: 18497856.
    Citations: 35     Fields:    Translation:AnimalsCells
  81. Knipe DM, Cliffe A. Chromatin control of herpes simplex virus lytic and latent infection. Nat Rev Microbiol. 2008 Mar; 6(3):211-21. PMID: 18264117.
    Citations: 166     Fields:    Translation:HumansAnimalsCells
  82. Johnson KE, Song B, Knipe DM. Role for herpes simplex virus 1 ICP27 in the inhibition of type I interferon signaling. Virology. 2008 May 10; 374(2):487-94. PMID: 18279905.
    Citations: 43     Fields:    Translation:AnimalsCells
  83. Fontaine-Rodriguez EC, Knipe DM. Herpes simplex virus ICP27 increases translation of a subset of viral late mRNAs. J Virol. 2008 Apr; 82(7):3538-45. PMID: 18216091.
    Citations: 35     Fields:    Translation:AnimalsCells
  84. Dudek T, Mathews LC, Knipe DM. Disruption of the U(L)41 gene in the herpes simplex virus 2 dl5-29 mutant increases its immunogenicity and protective capacity in a murine model of genital herpes. Virology. 2008 Mar 01; 372(1):165-75. PMID: 18006033.
    Citations: 18     Fields:    Translation:AnimalsCells
  85. van Lint AL, Torres-Lopez E, Knipe DM. Immunization with a replication-defective herpes simplex virus 2 mutant reduces herpes simplex virus 1 infection and prevents ocular disease. Virology. 2007 Nov 25; 368(2):227-31. PMID: 17915278.
    Citations: 13     Fields:    Translation:AnimalsCellsPHPublic Health
  86. Dodson AW, Taylor TJ, Knipe DM, Coen DM. Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach. Virology. 2007 Sep 30; 366(2):340-8. PMID: 17544048.
    Citations: 14     Fields:    Translation:AnimalsCells
  87. Melroe GT, Silva L, Schaffer PA, Knipe DM. Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-beta induction. Virology. 2007 Apr 10; 360(2):305-21. PMID: 17126870.
    Citations: 65     Fields:    Translation:HumansCells
  88. Petit CM, Chouljenko VN, Iyer A, Colgrove R, Farzan M, Knipe DM, Kousoulas KG. Palmitoylation of the cysteine-rich endodomain of the SARS-coronavirus spike glycoprotein is important for spike-mediated cell fusion. Virology. 2007 Apr 10; 360(2):264-74. PMID: 17134730.
    Citations: 14     Fields:    Translation:AnimalsCells
  89. Orlando JS, Balliet JW, Kushnir AS, Astor TL, Kosz-Vnenchak M, Rice SA, Knipe DM, Schaffer PA. ICP22 is required for wild-type composition and infectivity of herpes simplex virus type 1 virions. J Virol. 2006 Oct; 80(19):9381-90. PMID: 16973544.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  90. Watanabe D, Brockman MA, Ndung'u T, Mathews L, Lucas WT, Murphy CG, Felber BK, Pavlakis GN, Deluca NA, Knipe DM. Properties of a herpes simplex virus multiple immediate-early gene-deleted recombinant as a vaccine vector. Virology. 2007 Jan 20; 357(2):186-98. PMID: 16996101.
    Citations: 13     Fields:    Translation:AnimalsCells
  91. Kaur A, Sanford HB, Garry D, Lang S, Klumpp SA, Watanabe D, Bronson RT, Lifson JD, Rosati M, Pavlakis GN, Felber BK, Knipe DM, Desrosiers RC. Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus. Virology. 2007 Jan 20; 357(2):199-214. PMID: 16962628.
    Citations: 21     Fields:    Translation:AnimalsCellsPHPublic Health
  92. Brockman MA, Verschoor A, Zhu J, Carroll MC, Knipe DM. Optimal long-term humoral responses to replication-defective herpes simplex virus require CD21/CD35 complement receptor expression on stromal cells. J Virol. 2006 Jul; 80(14):7111-7. PMID: 16809316.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  93. Watanabe D, Knipe DM. [Application of herpes simplex virus to HIV vaccine vector]. Nihon Rinsho. 2006 Mar; 64 Suppl 3:366-70. PMID: 16615500.
    Citations:    Fields:    Translation:HumansAnimalsCells
  94. Dudek T, Knipe DM. Replication-defective viruses as vaccines and vaccine vectors. Virology. 2006 Jan 05; 344(1):230-9. PMID: 16364753.
    Citations: 55     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  95. Pesola JM, Zhu J, Knipe DM, Coen DM. Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production. J Virol. 2005 Dec; 79(23):14516-25. PMID: 16282451.
    Citations: 38     Fields:    Translation:AnimalsCells
  96. Palliser D, Chowdhury D, Wang QY, Lee SJ, Bronson RT, Knipe DM, Lieberman J. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature. 2006 Jan 05; 439(7072):89-94. PMID: 16306938.
    Citations: 107     Fields:    Translation:AnimalsCells
  97. Wang QY, Zhou C, Johnson KE, Colgrove RC, Coen DM, Knipe DM. Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection. Proc Natl Acad Sci U S A. 2005 Nov 01; 102(44):16055-9. PMID: 16247011.
    Citations: 120     Fields:    Translation:AnimalsCells
  98. Simpson-Holley M, Colgrove RC, Nalepa G, Harper JW, Knipe DM. Identification and functional evaluation of cellular and viral factors involved in the alteration of nuclear architecture during herpes simplex virus 1 infection. J Virol. 2005 Oct; 79(20):12840-51. PMID: 16188986.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  99. LaVail JH, Tauscher AN, Hicks JW, Harrabi O, Melroe GT, Knipe DM. Genetic and molecular in vivo analysis of herpes simplex virus assembly in murine visual system neurons. J Virol. 2005 Sep; 79(17):11142-50. PMID: 16103165.
    Citations: 17     Fields:    Translation:AnimalsCells
  100. Petit CM, Melancon JM, Chouljenko VN, Colgrove R, Farzan M, Knipe DM, Kousoulas KG. Genetic analysis of the SARS-coronavirus spike glycoprotein functional domains involved in cell-surface expression and cell-to-cell fusion. Virology. 2005 Oct 25; 341(2):215-30. PMID: 16099010.
    Citations: 8     Fields:    Translation:AnimalsCells
  101. Kurt-Jones EA, Belko J, Yu C, Newburger PE, Wang J, Chan M, Knipe DM, Finberg RW. The role of toll-like receptors in herpes simplex infection in neonates. J Infect Dis. 2005 Mar 01; 191(5):746-8. PMID: 15688290.
    Citations: 32     Fields:    Translation:HumansCells
  102. Olesky M, McNamee EE, Zhou C, Taylor TJ, Knipe DM. Evidence for a direct interaction between HSV-1 ICP27 and ICP8 proteins. Virology. 2005 Jan 05; 331(1):94-105. PMID: 15582656.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  103. Finberg RW, Knipe DM, Kurt-Jones EA. Herpes simplex virus and toll-like receptors. Viral Immunol. 2005; 18(3):457-65. PMID: 16212524.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  104. Hoshino Y, Dalai SK, Wang K, Pesnicak L, Lau TY, Knipe DM, Cohen JI, Straus SE. Comparative efficacy and immunogenicity of replication-defective, recombinant glycoprotein, and DNA vaccines for herpes simplex virus 2 infections in mice and guinea pigs. J Virol. 2005 Jan; 79(1):410-8. PMID: 15596834.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  105. Fontaine-Rodriguez EC, Taylor TJ, Olesky M, Knipe DM. Proteomics of herpes simplex virus infected cell protein 27: association with translation initiation factors. Virology. 2004 Dec 20; 330(2):487-92. PMID: 15567442.
    Citations: 37     Fields:    Translation:HumansCells
  106. Cook WJ, Kramer MF, Walker RM, Burwell TJ, Holman HA, Coen DM, Knipe DM. Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection. Virol J. 2004 Sep 23; 1:5. PMID: 15507126.
    Citations: 24     Fields:    Translation:AnimalsCells
  107. Melroe GT, DeLuca NA, Knipe DM. Herpes simplex virus 1 has multiple mechanisms for blocking virus-induced interferon production. J Virol. 2004 Aug; 78(16):8411-20. PMID: 15280450.
    Citations: 94     Fields:    Translation:HumansCells
  108. Taylor TJ, Knipe DM. Proteomics of herpes simplex virus replication compartments: association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8. J Virol. 2004 Jun; 78(11):5856-66. PMID: 15140983.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  109. Simpson-Holley M, Baines J, Roller R, Knipe DM. Herpes simplex virus 1 U(L)31 and U(L)34 gene products promote the late maturation of viral replication compartments to the nuclear periphery. J Virol. 2004 Jun; 78(11):5591-600. PMID: 15140956.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  110. Kurt-Jones EA, Chan M, Zhou S, Wang J, Reed G, Bronson R, Arnold MM, Knipe DM, Finberg RW. Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci U S A. 2004 Feb 03; 101(5):1315-20. PMID: 14739339.
    Citations: 206     Fields:    Translation:HumansAnimalsCells
  111. Pearson A, Knipe DM, Coen DM. ICP27 selectively regulates the cytoplasmic localization of a subset of viral transcripts in herpes simplex virus type 1-infected cells. J Virol. 2004 Jan; 78(1):23-32. PMID: 14671084.
    Citations: 11     Fields:    Translation:AnimalsCells
  112. Verschoor A, Brockman MA, Gadjeva M, Knipe DM, Carroll MC. Myeloid C3 determines induction of humoral responses to peripheral herpes simplex virus infection. J Immunol. 2003 Nov 15; 171(10):5363-71. PMID: 14607939.
    Citations: 27     Fields:    Translation:AnimalsCells
  113. Jones CA, Knipe D. Herpes simplex virus vaccines. Pediatr Infect Dis J. 2003 Nov; 22(11):1003-5. PMID: 14614374.
    Citations: 1     Fields:    Translation:Humans
  114. Kramer MF, Cook WJ, Roth FP, Zhu J, Holman H, Knipe DM, Coen DM. Latent herpes simplex virus infection of sensory neurons alters neuronal gene expression. J Virol. 2003 Sep; 77(17):9533-41. PMID: 12915567.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  115. Uprichard SL, Knipe DM. Conformational changes in the herpes simplex virus ICP8 DNA-binding protein coincident with assembly in viral replication structures. J Virol. 2003 Jul; 77(13):7467-76. PMID: 12805446.
    Citations: 6     Fields:    Translation:Cells
  116. Wakimoto H, Johnson PR, Knipe DM, Chiocca EA. Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells. Gene Ther. 2003 Jun; 10(11):983-90. PMID: 12756419.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  117. Taylor TJ, McNamee EE, Day C, Knipe DM. Herpes simplex virus replication compartments can form by coalescence of smaller compartments. Virology. 2003 May 10; 309(2):232-47. PMID: 12758171.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  118. Taylor TJ, Knipe DM. C-terminal region of herpes simplex virus ICP8 protein needed for intranuclear localization. Virology. 2003 May 10; 309(2):219-31. PMID: 12758170.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  119. Kramer M, Riley J, Spoering A, Coen D, Knipe D. Effect of immunization on herpes simplex virus type 1 latent infection in the trigeminal ganglion. Curr Eye Res. 2003 Mar-Apr; 26(3-4):185-94. PMID: 12815546.
    Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
  120. Zhao X, Deak E, Soderberg K, Linehan M, Spezzano D, Zhu J, Knipe DM, Iwasaki A. Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2. J Exp Med. 2003 Jan 20; 197(2):153-62. PMID: 12538655.
    Citations: 137     Fields:    Translation:AnimalsCells
  121. Knipe DM. Viral vaccines: Past, present and future. Medicina Universitaria. 2003; 5:116-122.
  122. Mann MA, Tyler KL, Knipe DM, Fields BN. Type 3 reovirus neuroinvasion after intramuscular inoculation: viral genetic determinants of lethality and spinal cord infection. Virology. 2002 Nov 25; 303(2):213-21. PMID: 12490384.
    Citations: 2     Fields:    Translation:AnimalsCells
  123. Mann MA, Knipe DM, Fischbach GD, Fields BN. Type 3 reovirus neuroinvasion after intramuscular inoculation: direct invasion of nerve terminals and age-dependent pathogenesis. Virology. 2002 Nov 25; 303(2):222-31. PMID: 12490385.
    Citations: 11     Fields:    Translation:AnimalsCells
  124. Gadjeva M, Verschoor A, Brockman MA, Jezak H, Shen LM, Knipe DM, Carroll MC. Macrophage-derived complement component C4 can restore humoral immunity in C4-deficient mice. J Immunol. 2002 Nov 15; 169(10):5489-95. PMID: 12421924.
    Citations: 15     Fields:    Translation:AnimalsCells
  125. Zhou C, Knipe DM. Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme. J Virol. 2002 Jun; 76(12):5893-904. PMID: 12021322.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  126. Chen SH, Lee LY, Garber DA, Schaffer PA, Knipe DM, Coen DM. Neither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virus. J Virol. 2002 May; 76(10):4764-72. PMID: 11967293.
    Citations: 32     Fields:    Translation:AnimalsCells
  127. Brockman MA, Knipe DM. Herpes simplex virus vectors elicit durable immune responses in the presence of preexisting host immunity. J Virol. 2002 Apr; 76(8):3678-87. PMID: 11907207.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  128. Taylor TJ, Brockman MA, McNamee EE, Knipe DM. Herpes simplex virus. Front Biosci. 2002 Mar 01; 7:d752-64. PMID: 11861220.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  129. Lucas WT, Knipe DM. "Viral capsids and envelopes: Structure and Function.". Encyclopedia of Life Sciences. Available as a PDF file on David Knipe Website. 2002.
  130. Song B, Yeh KC, Liu J, Knipe DM. Herpes simplex virus gene products required for viral inhibition of expression of G1-phase functions. Virology. 2001 Nov 25; 290(2):320-8. PMID: 11883196.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  131. Da Costa XJ, Morrison LA, Knipe DM. Comparison of different forms of herpes simplex replication-defective mutant viruses as vaccines in a mouse model of HSV-2 genital infection. Virology. 2001 Sep 30; 288(2):256-63. PMID: 11601897.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  132. Verschoor A, Brockman MA, Knipe DM, Carroll MC. Cutting edge: myeloid complement C3 enhances the humoral response to peripheral viral infection. J Immunol. 2001 Sep 01; 167(5):2446-51. PMID: 11509581.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  133. Jean S, LeVan KM, Song B, Levine M, Knipe DM. Herpes simplex virus 1 ICP27 is required for transcription of two viral late (gamma 2) genes in infected cells. Virology. 2001 May 10; 283(2):273-84. PMID: 11336552.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  134. Deshpande SP, Lee S, Zheng M, Song B, Knipe D, Kapp JA, Rouse BT. Herpes simplex virus-induced keratitis: evaluation of the role of molecular mimicry in lesion pathogenesis. J Virol. 2001 Apr; 75(7):3077-88. PMID: 11238834.
    Citations: 16     Fields: