Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Nader Najafian, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56AI101150 (NAJAFIAN, NADER) Aug 20, 2013 - Jul 31, 2015
    TIM molecules and the innate: adaptive interface in alloimmunity
    Role: Principal Investigator
  2. R56AI089777 (NAJAFIAN, NADER) Aug 15, 2011 - Jul 31, 2012
    TIM-3: Galectin-9: A Novel Regulatory Pathway of Alloimmune Activation
    Role: Principal Investigator
  3. K08AI064335 (NAJAFIAN, NADER) Jun 1, 2007 - May 31, 2010
    Negative Costimulatory Pathways in Rejection &Tolerance
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Nester C, Appel GB, Bomback AS, Bouman KP, Cook HT, Daina E, Dixon BP, Rice K, Najafian N, Hui J, Podos SD, Langman CB, Lightstone L, Parikh SV, Pickering MC, Sperati CJ, Trachtman H, Tumlin J, de Vries AP, Wetzels JFM, Remuzzi G. Clinical Outcomes of Patients with C3G or IC-MPGN Treated with the Factor D Inhibitor Danicopan: Final Results from Two Phase 2 Studies. Am J Nephrol. 2022; 53(10):687-700. PMID: 36423588.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  2. Vassiliou D, Sardh E, Harper P, Simon AR, Clausen VA, Najafian N, Robbie GJ, Agarwal S. A Drug-Drug Interaction Study Evaluating the Effect of Givosiran, a Small Interfering Ribonucleic Acid, on Cytochrome P450 Activity in the Liver. Clin Pharmacol Ther. 2021 11; 110(5):1250-1260. PMID: 34510420.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  3. Badri P, Jiang X, Borodovsky A, Najafian N, Kim J, Clausen VA, Goel V, Habtemariam B, Robbie GJ. Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria. Clin Pharmacokinet. 2021 03; 60(3):365-378. PMID: 33047216; PMCID: PMC9203406.
    Citations: 7     Fields:    Translation:Humans
  4. Zhang W, Yi Z, Keung KL, Shang H, Wei C, Cravedi P, Sun Z, Xi C, Woytovich C, Farouk S, Huang W, Banu K, Gallon L, Magee CN, Najafian N, Samaniego M, Djamali A, Alexander SI, Rosales IA, Smith RN, Xiang J, Lerut E, Kuypers D, Naesens M, O'Connell PJ, Colvin R, Menon MC, Murphy B. A Peripheral Blood Gene Expression Signature to Diagnose Subclinical Acute Rejection. J Am Soc Nephrol. 2019 08; 30(8):1481-1494. PMID: 31278196; PMCID: PMC6683710.
    Citations: 22     Fields:    Translation:Humans
  5. Magee CN, Murakami N, Borges TJ, Shimizu T, Safa K, Ohori S, Cai S, Uffing A, Azzi J, Elyaman W, Charbonnier LM, Liu K, Toprak D, Visner G, Chatila TA, Siebel CW, Najafian N, Riella LV. Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms. Circulation. 2019 09 09; 140(10):846-863. PMID: 31266349; PMCID: PMC6722011.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  6. Zhang W, Yi Z, Wei C, Keung KL, Sun Z, Xi C, Woytovich C, Farouk S, Gallon L, Menon MC, Magee C, Najafian N, Samaniego MD, Djamali A, Alexander SI, Rosales IA, Smith RN, O'Connell PJ, Colvin R, Cravedi P, Murphy B. Pretransplant transcriptomic signature in peripheral blood predicts early acute rejection. JCI Insight. 2019 06 06; 4(11). PMID: 31167967.
    Citations: 7     Fields:    Translation:HumansCells
  7. Désy O, Béland S, Vallin P, Riopel J, Latulippe E, Najafian N, Chandraker A, Agharazii M, Batal I, De Serres SA. IL-6 production by monocytes is associated with graft function decline in patients with borderline changes suspicious for acute T-cell-mediated rejection: a pilot study. Transpl Int. 2018 01; 31(1):92-101. PMID: 28906029.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  8. Echenique IA, Beltran D, Ramirez-Ruiz L, Najafian N, Agrawal N. Ganciclovir Dosing Strategies and Development of Cytomegalovirus Resistance in a Kidney Transplant Recipient: A Case Report. Transplant Proc. 2017 Sep; 49(7):1560-1564. PMID: 28838440.
    Citations: 2     Fields:    Translation:HumansCells
  9. Schütte-Nütgen K, Boenisch O, Harrach H, Casey A, Guleria I, Najafian N, Sayegh MH, Gerard CJ, Subramaniam M. Divergent Function of Programmed Death-Ligand 1 in Donor Tissue versus Recipient Immune System in a Murine Model of Bronchiolitis Obliterans. Am J Pathol. 2017 Jun; 187(6):1368-1379. PMID: 28427861; PMCID: PMC5455059.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  10. O'Connell PJ, Zhang W, Menon MC, Yi Z, Schröppel B, Gallon L, Luan Y, Rosales IA, Ge Y, Losic B, Xi C, Woytovich C, Keung KL, Wei C, Greene I, Overbey J, Bagiella E, Najafian N, Samaniego M, Djamali A, Alexander SI, Nankivell BJ, Chapman JR, Smith RN, Colvin R, Murphy B. Biopsy transcriptome expression profiling to identify kidney transplants at risk of chronic injury: a multicentre, prospective study. Lancet. 2016 Sep 03; 388(10048):983-93. PMID: 27452608; PMCID: PMC5014570.
    Citations: 60     Fields:    Translation:HumansCTClinical Trials
  11. Liebow A, Li X, Racie T, Hettinger J, Bettencourt BR, Najafian N, Haslett P, Fitzgerald K, Holmes RP, Erbe D, Querbes W, Knight J. An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria. J Am Soc Nephrol. 2017 02; 28(2):494-503. PMID: 27432743; PMCID: PMC5280024.
    Citations: 74     Fields:    Translation:Animals
  12. Borges TJ, O'Malley JT, Wo L, Murakami N, Smith B, Azzi J, Tripathi S, Lane JD, Bueno EM, Clark RA, Tullius SG, Chandraker A, Lian CG, Murphy GF, Strom TB, Pomahac B, Najafian N, Riella LV. Codominant Role of Interferon-?- and Interleukin-17-Producing T Cells During Rejection in Full Facial Transplant Recipients. Am J Transplant. 2016 07; 16(7):2158-71. PMID: 26749226; PMCID: PMC4979599.
    Citations: 15     Fields:    Translation:HumansCells
  13. Batal I, De Serres SA, Safa K, Bijol V, Ueno T, Onozato ML, Iafrate AJ, Herter JM, Lichtman AH, Mayadas TN, Guleria I, Rennke HG, Najafian N, Chandraker A. Dendritic Cells in Kidney Transplant Biopsy Samples Are Associated with T Cell Infiltration and Poor Allograft Survival. J Am Soc Nephrol. 2015 Dec; 26(12):3102-13. PMID: 25855773; PMCID: PMC4657833.
    Citations: 15     Fields:    Translation:HumansCells
  14. Yeung MY, Ding Q, Brooks CR, Xiao S, Workman CJ, Vignali DA, Ueno T, Padera RF, Kuchroo VK, Najafian N, Rothstein DM. TIM-1 signaling is required for maintenance and induction of regulatory B cells. Am J Transplant. 2015 Apr; 15(4):942-53. PMID: 25645598; PMCID: PMC4530122.
    Citations: 39     Fields:    Translation:AnimalsCells
  15. Gallon L, Traitanon O, Sustento-Reodica N, Leventhal J, Ansari MJ, Gehrau RC, Ariyamuthu V, De Serres SA, Alvarado A, Chhabra D, Mathew JM, Najafian N, Mas V. Cellular and molecular immune profiles in renal transplant recipients after conversion from tacrolimus to sirolimus. Kidney Int. 2015 Apr; 87(4):828-38. PMID: 25354238.
    Citations: 18     Fields:    Translation:HumansCells
  16. Cousens L, Najafian N, Martin WD, De Groot AS. Tregitope: Immunomodulation powerhouse. Hum Immunol. 2014 Dec; 75(12):1139-46. PMID: 25454619.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  17. Grafals M, Smith B, Murakami N, Trabucco A, Hamill K, Marangos E, Gilligan H, Pomfret EA, Pomposelli JJ, Simpson MA, Azzi J, Najafian N, Riella LV. Immunophenotyping and efficacy of low dose ATG in non-sensitized kidney recipients undergoing early steroid withdrawal: a randomized pilot study. PLoS One. 2014; 9(8):e104408. PMID: 25111080; PMCID: PMC4128673.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  18. Riella LV, Safa K, Yagan J, Lee B, Azzi J, Najafian N, Abdi R, Milford E, Mah H, Gabardi S, Malek S, Tullius SG, Magee C, Chandraker A. Long-term outcomes of kidney transplantation across a positive complement-dependent cytotoxicity crossmatch. Transplantation. 2014 Jun 27; 97(12):1247-52. PMID: 24854670.
    Citations: 13     Fields:    Translation:Humans
  19. Batal I, De Serres SA, Mfarrej BG, Grafals M, Pinkus GS, Kalra A, Weins A, Bijol V, Rennke HG, Guleria I, Abdi R, Chandraker A, Najafian N. Glomerular inflammation correlates with endothelial injury and with IL-6 and IL-1ß secretion in the peripheral blood. Transplantation. 2014 May 27; 97(10):1034-42. PMID: 24406453.
    Citations: 10     Fields:    Translation:HumansCells
  20. Abdoli R, Najafian N. T Helper Cells Fate Mapping by Co-stimulatory Molecules and its Functions in Allograft Rejection and Tolerance. Int J Organ Transplant Med. 2014; 5(3):97-110. PMID: 25184030.
    Citations: 6     
  21. Yeung MY, Najafian N, Sayegh MH. Targeting CD28 to prevent transplant rejection. Expert Opin Ther Targets. 2014 Feb; 18(2):225-42. PMID: 24329604.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  22. Yeung MY, McGrath MM, Nakayama M, Shimizu T, Boenisch O, Magee CN, Abdoli R, Akiba H, Ueno T, Turka LA, Najafian N. Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival. J Immunol. 2013 Oct 15; 191(8):4447-55. PMID: 24038092; PMCID: PMC3804420.
    Citations: 17     Fields:    Translation:AnimalsCells
  23. Saha A, Aoyama K, Taylor PA, Koehn BH, Veenstra RG, Panoskaltsis-Mortari A, Munn DH, Murphy WJ, Azuma M, Yagita H, Fife BT, Sayegh MH, Najafian N, Socie G, Ahmed R, Freeman GJ, Sharpe AH, Blazar BR. Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality. Blood. 2013 Oct 24; 122(17):3062-73. PMID: 24030385; PMCID: PMC3811178.
    Citations: 95     Fields:    Translation:AnimalsCells
  24. Chhabra D, Alvarado A, Dalal P, Leventhal J, Wang C, Sustento-Reodica N, Najafian N, Skaro A, Levitsky J, Mas V, Gallon L. Impact of calcineurin-inhibitor conversion to mTOR inhibitor on renal allograft function in a prednisone-free regimen. Am J Transplant. 2013 Nov; 13(11):2902-11. PMID: 24007570.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  25. Ashoor I, Najafian N, Korin Y, Reed EF, Mohanakumar T, Ikle D, Heeger PS, Lin M. Standardization and cross validation of alloreactive IFN? ELISPOT assays within the clinical trials in organ transplantation consortium. Am J Transplant. 2013 Jul; 13(7):1871-9. PMID: 23710568; PMCID: PMC3839289.
    Citations: 28     Fields:    Translation:HumansCells
  26. Riella LV, Yang J, Chock S, Safa K, Magee CN, Vanguri V, Elyaman W, Lahoud Y, Yagita H, Abdi R, Najafian N, Medina-Pestana JO, Chandraker A. Jagged2-signaling promotes IL-6-dependent transplant rejection. Eur J Immunol. 2013 Jun; 43(6):1449-58. PMID: 23526606.
    Citations: 18     Fields:    Translation:AnimalsCells
  27. D'Addio F, Boenisch O, Magee CN, Yeung MY, Yuan X, Mfarrej B, Vergani A, Ansari MJ, Fiorina P, Najafian N. Prolonged, low-dose anti-thymocyte globulin, combined with CTLA4-Ig, promotes engraftment in a stringent transplant model. PLoS One. 2013; 8(1):e53797. PMID: 23326509; PMCID: PMC3542267.
    Citations: 10     Fields:    Translation:HumansAnimals
  28. Chabtini L, Mfarrej B, Mounayar M, Zhu B, Batal I, Dakle PJ, Smith BD, Boenisch O, Najafian N, Akiba H, Yagita H, Guleria I. TIM-3 regulates innate immune cells to induce fetomaternal tolerance. J Immunol. 2013 Jan 01; 190(1):88-96. PMID: 23180822; PMCID: PMC3529820.
    Citations: 46     Fields:    Translation:AnimalsCells
  29. Cousens LP, Najafian N, Mingozzi F, Elyaman W, Mazer B, Moise L, Messitt TJ, Su Y, Sayegh M, High K, Khoury SJ, Scott DW, De Groot AS. In vitro and in vivo studies of IgG-derived Treg epitopes (Tregitopes): a promising new tool for tolerance induction and treatment of autoimmunity. J Clin Immunol. 2013 Jan; 33 Suppl 1:S43-9. PMID: 22941509.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  30. Ueno T, Yeung MY, McGrath M, Yang S, Zaman N, Snawder B, Padera RF, Magee CN, Gorbatov R, Hashiguchi M, Azuma M, Freeman GJ, Sayegh MH, Najafian N. Intact B7-H3 signaling promotes allograft prolongation through preferential suppression of Th1 effector responses. Eur J Immunol. 2012 Sep; 42(9):2343-53. PMID: 22733595.
    Citations: 14     Fields:    Translation:AnimalsCells
  31. Magee CN, Boenisch O, Najafian N. The role of costimulatory molecules in directing the functional differentiation of alloreactive T helper cells. Am J Transplant. 2012 Oct; 12(10):2588-600. PMID: 22759274; PMCID: PMC3459149.
    Citations: 14     Fields:    Translation:HumansCells
  32. De Serres SA, Mfarrej BG, Grafals M, Riella LV, Magee CN, Yeung MY, Dyer C, Ahmad U, Chandraker A, Najafian N. Derivation and validation of a cytokine-based assay to screen for acute rejection in renal transplant recipients. Clin J Am Soc Nephrol. 2012 Jun; 7(6):1018-25. PMID: 22498498.
    Citations: 11     Fields:    Translation:HumansCells
  33. McGrath MM, Najafian N. The role of coinhibitory signaling pathways in transplantation and tolerance. Front Immunol. 2012; 3:47. PMID: 22566929.
    Citations: 29     Fields:    
  34. Boenisch O, Lopez M, Elyaman W, Magee CN, Ahmad U, Najafian N. Ex vivo expansion of human Tregs by rabbit ATG is dependent on intact STAT3-signaling in CD4? T cells and requires the presence of monocytes. Am J Transplant. 2012 Apr; 12(4):856-66. PMID: 22390202; PMCID: PMC3777828.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  35. Ashoor IF, Najafian N. Rejection and regulation: a tight balance. Curr Opin Organ Transplant. 2012 Feb; 17(1):1-7. PMID: 22157321.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  36. Yamada Y, Boskovic S, Aoyama A, Murakami T, Putheti P, Smith RN, Ochiai T, Nadazdin O, Koyama I, Boenisch O, Najafian N, Bhasin MK, Colvin RB, Madsen JC, Strom TB, Sachs DH, Benichou G, Cosimi AB, Kawai T. Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates. Am J Transplant. 2012 Feb; 12(2):330-40. PMID: 22053723; PMCID: PMC3268945.
    Citations: 54     Fields:    Translation:AnimalsCells
  37. De Serres SA, Mfarrej BG, Magee CN, Benitez F, Ashoor I, Sayegh MH, Harmon WE, Najafian N. Immune profile of pediatric renal transplant recipients following alemtuzumab induction. J Am Soc Nephrol. 2012 Jan; 23(1):174-82. PMID: 22052056; PMCID: PMC3269923.
    Citations: 12     Fields:    Translation:HumansCellsCTClinical Trials
  38. Riella LV, Ueno T, Batal I, De Serres SA, Bassil R, Elyaman W, Yagita H, Medina-Pestana JO, Chandraker A, Najafian N. Blockade of Notch ligand d1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation. J Immunol. 2011 Nov 01; 187(9):4629-38. PMID: 21949024; PMCID: PMC3197868.
    Citations: 21     Fields:    Translation:AnimalsCells
  39. Ueno T, Yamada A, Ito T, Yeung MY, Gorbatov R, Shimizu T, Abdi R, Sayegh MH, Auchincloss H, Najafian N. Role of nuclear factor of activated T cell (NFAT) transcription factors in skin and vascularized cardiac allograft rejection. Transplantation. 2011 Sep 15; 92(5):e26-7. PMID: 21866037.
    Citations: 3     Fields:    Translation:AnimalsCells
  40. Yeung MY, McGrath M, Najafian N. The emerging role of the TIM molecules in transplantation. Am J Transplant. 2011 Oct; 11(10):2012-9. PMID: 21906254; PMCID: PMC3205957.
    Citations: 18     Fields:    Translation:HumansAnimals
  41. Ding Q, Yeung M, Camirand G, Zeng Q, Akiba H, Yagita H, Chalasani G, Sayegh MH, Najafian N, Rothstein DM. Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice. J Clin Invest. 2011 Sep; 121(9):3645-56. PMID: 21821911; PMCID: PMC3163958.
    Citations: 206     Fields:    Translation:HumansAnimalsCells
  42. De Serres SA, Yeung MY, Mfarrej BG, Najafian N. Effect of biologic agents on regulatory T cells. Transplant Rev (Orlando). 2011 Jul; 25(3):110-6. PMID: 21514136.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  43. De Serres SA, Vadivel N, Mfarrej BG, Grafals M, DeJoseph M, Dyer C, Magee CN, Chandraker A, Gallon LG, Najafian N. Monocyte-secreted inflammatory cytokines are associated with transplant glomerulopathy in renal allograft recipients. Transplantation. 2011 Mar 15; 91(5):552-9. PMID: 21150704.
    Citations: 10     Fields:    Translation:HumansCells
  44. Riella LV, Watanabe T, Sage PT, Yang J, Yeung M, Azzi J, Vanguri V, Chandraker A, Sharpe AH, Sayegh MH, Najafian N. Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts. Am J Transplant. 2011 Apr; 11(4):832-40. PMID: 21401869.
    Citations: 22     Fields:    Translation:AnimalsCells
  45. Rong S, Park JK, Kirsch T, Yagita H, Akiba H, Boenisch O, Haller H, Najafian N, Habicht A. The TIM-1:TIM-4 pathway enhances renal ischemia-reperfusion injury. J Am Soc Nephrol. 2011 Mar; 22(3):484-95. PMID: 21355054.
    Citations: 23     Fields:    Translation:AnimalsCells
  46. Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N. TIM-3: a novel regulatory molecule of alloimmune activation. J Immunol. 2010 Nov 15; 185(10):5806-19. PMID: 20956339; PMCID: PMC3619947.
    Citations: 35     Fields:    Translation:AnimalsCells
  47. Yamaura K, Watanabe T, Boenisch O, Yeung M, Yang S, Magee CN, Padera R, Datta S, Schatton T, Kamimura Y, Azuma M, Najafian N. In vivo function of immune inhibitory molecule B7-H4 in alloimmune responses. Am J Transplant. 2010 Oct; 10(10):2355-62. PMID: 21143433.
    Citations: 9     Fields:    Translation:AnimalsCells
  48. D'Addio F, Yuan X, Habicht A, Williams J, Ruzek M, Iacomini J, Turka LA, Sayegh MH, Najafian N, Ansari MJ. A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model. Transplantation. 2010 Aug 15; 90(3):260-9. PMID: 20712076; PMCID: PMC4140399.
    Citations: 18     Fields:    Translation:AnimalsCells
  49. Uchida Y, Ke B, Freitas MC, Yagita H, Akiba H, Busuttil RW, Najafian N, Kupiec-Weglinski JW. T-cell immunoglobulin mucin-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner. Gastroenterology. 2010 Dec; 139(6):2195-206. PMID: 20637206; PMCID: PMC2970711.
    Citations: 51     Fields:    Translation:AnimalsCells
  50. Gabardi S, Waikar SS, Martin S, Roberts K, Chen J, Borgi L, Sheashaa H, Dyer C, Malek SK, Tullius SG, Vadivel N, Grafals M, Abdi R, Najafian N, Milford E, Chandraker A. Evaluation of fluoroquinolones for the prevention of BK viremia after renal transplantation. Clin J Am Soc Nephrol. 2010 Jul; 5(7):1298-304. PMID: 20507960.
    Citations: 26     Fields:    Translation:HumansCells
  51. Uchida Y, Ke B, Freitas MC, Ji H, Zhao D, Benjamin ER, Najafian N, Yagita H, Akiba H, Busuttil RW, Kupiec-Weglinski JW. The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse. Hepatology. 2010 Apr; 51(4):1363-72. PMID: 20091883.
    Citations: 34     Fields:    Translation:AnimalsCells
  52. Yamaura K, Boenisch O, Watanabe T, Ueno T, Vanguri V, Yang J, Tanaka K, Guleria I, Borst J, Zhai Y, Kupiec-Weglinski JW, Najafian N. Differential requirement of CD27 costimulatory signaling for naïve versus alloantigen-primed effector/memory CD8+ T cells. Am J Transplant. 2010 May; 10(5):1210-20. PMID: 20353477; PMCID: PMC2889922.
    Citations: 5     Fields:    Translation:AnimalsCells
  53. De Serres SA, Sayegh MH, Najafian N. Immunosuppressive drugs and Tregs: a critical evaluation! Clin J Am Soc Nephrol. 2009 Oct; 4(10):1661-9. PMID: 19696218.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  54. Benítez F, Najafian N. Novel noninvasive assays to predict transplantation rejection and tolerance: enumeration of cytokine-producing alloreactive T cells. Clin Lab Med. 2008 Sep; 28(3):365-73, v. PMID: 19028257.
    Citations: 3     Fields:    Translation:HumansCells
  55. Boenisch O, Sayegh MH, Najafian N. Negative T-cell costimulatory pathways: their role in regulating alloimmune responses. Curr Opin Organ Transplant. 2008 Aug; 13(4):373-8. PMID: 18685332.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  56. Womer KL, Magee CC, Najafian N, Vella JP, Milford EL, Sayegh MH, Carpenter CB. A pilot study on the immunological effects of oral administration of donor major histocompatibility complex class II peptides in renal transplant recipients. Clin Transplant. 2008 Nov-Dec; 22(6):754-9. PMID: 18647327.
    Citations: 1     Fields:    Translation:HumansCells
  57. Smith RN, Kent SC, Nagle J, Selig M, Iafrate AJ, Najafian N, Hafler DA, Auchincloss H, Orban T, Cagliero E. Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss. Transplantation. 2008 Jul 15; 86(1):54-62. PMID: 18622278.
    Citations: 11     Fields:    Translation:Humans
  58. Ueno T, Habicht A, Clarkson MR, Albin MJ, Yamaura K, Boenisch O, Popoola J, Wang Y, Yagita H, Akiba H, Ansari MJ, Yang J, Turka LA, Rothstein DM, Padera RF, Najafian N, Sayegh MH. The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model. J Clin Invest. 2008 Feb; 118(2):742-51. PMID: 18172549; PMCID: PMC2157561.
    Citations: 56     Fields:    Translation:AnimalsCells
  59. Tanaka K, Albin MJ, Yuan X, Yamaura K, Habicht A, Murayama T, Grimm M, Waaga AM, Ueno T, Padera RF, Yagita H, Azuma M, Shin T, Blazar BR, Rothstein DM, Sayegh MH, Najafian N. PDL1 is required for peripheral transplantation tolerance and protection from chronic allograft rejection. J Immunol. 2007 Oct 15; 179(8):5204-10. PMID: 17911605; PMCID: PMC2291549.
    Citations: 81     Fields:    Translation:Animals
  60. Habicht A, Najafian N, Yagita H, Sayegh MH, Clarkson MR. New insights in CD28-independent allograft rejection. Am J Transplant. 2007 Aug; 7(8):1917-26. PMID: 17617854.
    Citations: 6     Fields:    Translation:AnimalsCells
  61. Izawa A, Yamaura K, Albin MJ, Jurewicz M, Tanaka K, Clarkson MR, Ueno T, Habicht A, Freeman GJ, Yagita H, Abdi R, Pearson T, Greiner DL, Sayegh MH, Najafian N. A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo. J Immunol. 2007 Jul 15; 179(2):786-96. PMID: 17617568.
    Citations: 18     Fields:    Translation:AnimalsCells
  62. Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, Gutierrez C, Moll T, Sobel RA, Umetsu DT, Yagita H, Akiba H, Strom T, Sayegh MH, DeKruyff RH, Khoury SJ, Kuchroo VK. Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J Exp Med. 2007 Jul 09; 204(7):1691-702. PMID: 17606630; PMCID: PMC2118637.
    Citations: 72     Fields:    Translation:AnimalsCells
  63. Alegre ML, Najafian N. Costimulatory molecules as targets for the induction of transplantation tolerance. Curr Mol Med. 2006 Dec; 6(8):843-57. PMID: 17168736.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  64. Najafian N, Albin MJ, Newell KA. How can we measure immunologic tolerance in humans? J Am Soc Nephrol. 2006 Oct; 17(10):2652-63. PMID: 16928808.
    Citations: 12     Fields:    Translation:HumansAnimals
  65. Lopez M, Clarkson MR, Albin M, Sayegh MH, Najafian N. A novel mechanism of action for anti-thymocyte globulin: induction of CD4+CD25+Foxp3+ regulatory T cells. J Am Soc Nephrol. 2006 Oct; 17(10):2844-53. PMID: 16914538.
    Citations: 111     Fields:    Translation:HumansCells
  66. Ito T, Ueno T, Clarkson MR, Yuan X, Jurewicz MM, Yagita H, Azuma M, Sharpe AH, Auchincloss H, Sayegh MH, Najafian N. Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo. J Immunol. 2005 Jun 01; 174(11):6648-56. PMID: 15905503.
    Citations: 63     Fields:    Translation:AnimalsCells
  67. Sandner SE, Clarkson MR, Salama AD, Sanchez-Fueyo A, Domenig C, Habicht A, Najafian N, Yagita H, Azuma M, Turka LA, Sayegh MH. Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. J Immunol. 2005 Mar 15; 174(6):3408-15. PMID: 15749874.
    Citations: 69     Fields:    Translation:AnimalsCells
  68. Yamada A, Salama AD, Sho M, Najafian N, Ito T, Forman JP, Kewalramani R, Sandner S, Harada H, Clarkson MR, Mandelbrot DA, Sharpe AH, Oshima H, Yagita H, Chalasani G, Lakkis FG, Auchincloss H, Sayegh MH. CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo. J Immunol. 2005 Feb 01; 174(3):1357-64. PMID: 15661893.
    Citations: 26     Fields:    Translation:AnimalsCells
  69. Poggio ED, Clemente M, Riley J, Roddy M, Greenspan NS, Dejelo C, Najafian N, Sayegh MH, Hricik DE, Heeger PS. Alloreactivity in renal transplant recipients with and without chronic allograft nephropathy. J Am Soc Nephrol. 2004 Jul; 15(7):1952-60. PMID: 15213286.
    Citations: 31     Fields:    Translation:HumansCells
  70. Abdi R, Means TK, Ito T, Smith RN, Najafian N, Jurewicz M, Tchipachvili V, Charo I, Auchincloss H, Sayegh MH, Luster AD. Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo. J Immunol. 2004 Jan 15; 172(2):767-75. PMID: 14707046.
    Citations: 24     Fields:    Translation:AnimalsCells
  71. Najafian N, Chitnis T, Salama AD, Zhu B, Benou C, Yuan X, Clarkson MR, Sayegh MH, Khoury SJ. Regulatory functions of CD8+CD28- T cells in an autoimmune disease model. J Clin Invest. 2003 Oct; 112(7):1037-48. PMID: 14523041; PMCID: PMC198520.
    Citations: 94     Fields:    Translation:AnimalsCells
  72. Salama AD, Najafian N, Clarkson MR, Harmon WE, Sayegh MH. Regulatory CD25+ T cells in human kidney transplant recipients. J Am Soc Nephrol. 2003 Jun; 14(6):1643-51. PMID: 12761267.
    Citations: 41     Fields:    Translation:HumansCells
  73. Najafian N, Khoury SJ. T cell costimulatory pathways: blockade for autoimmunity. Expert Opin Biol Ther. 2003 Apr; 3(2):227-36. PMID: 12662138.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  74. Yuan X, Salama AD, Dong V, Schmitt I, Najafian N, Chandraker A, Akiba H, Yagita H, Sayegh MH. The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivo. J Immunol. 2003 Mar 15; 170(6):2949-55. PMID: 12626546.
    Citations: 23     Fields:    Translation:AnimalsCellsPHPublic Health
  75. Sho M, Sandner SE, Najafian N, Salama AD, Dong V, Yamada A, Kishimoto K, Harada H, Schmitt I, Sayegh MH. New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs. Ann Surg. 2002 Nov; 236(5):667-75. PMID: 12409674; PMCID: PMC1422626.
    Citations: 20     Fields:    Translation:AnimalsCells
  76. Sho M, Yamada A, Najafian N, Salama AD, Harada H, Sandner SE, Sanchez-Fueyo A, Zheng XX, Strom TB, Sayegh MH. Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size. J Immunol. 2002 Oct 01; 169(7):3744-51. PMID: 12244168.
    Citations: 22     Fields:    Translation:AnimalsCells
  77. Kist-van Holthe JE, Gasser M, Womer K, Najafian N, Dong V, Samsonov DV, Geehan CS, Chandraker A, Sayegh MH, Waaga AM. Regulatory functions of alloreactive Th2 clones in human renal transplant recipients. Kidney Int. 2002 Aug; 62(2):627-31. PMID: 12110027.
    Citations: 10     Fields:    Translation:HumansCells
  78. Abdi R, Smith RN, Makhlouf L, Najafian N, Luster AD, Auchincloss H, Sayegh MH. The role of CC chemokine receptor 5 (CCR5) in islet allograft rejection. Diabetes. 2002 Aug; 51(8):2489-95. PMID: 12145162.
    Citations: 23     Fields:    Translation:AnimalsCells
  79. Najafian N, Salama AD, Fedoseyeva EV, Benichou G, Sayegh MH. Enzyme-linked immunosorbent spot assay analysis of peripheral blood lymphocyte reactivity to donor HLA-DR peptides: potential novel assay for prediction of outcomes for renal transplant recipients. J Am Soc Nephrol. 2002 Jan; 13(1):252-259. PMID: 11752045.
    Citations: 30     Fields:    Translation:HumansCells
  80. Yamada A, Salama AD, Najafian N, Auchincloss H, Sayegh MH. TNF:TNF-R T-Cell costimulatory pathways in transplantation. Transplant Proc. 2001 Nov-Dec; 33(7-8):3070-1. PMID: 11750320.
    Citations: 1     Fields:    Translation:HumansCells
  81. Sho M, Salama AD, Yamada A, Najafian N, Sayegh MH. Physiologic regulation of alloimmune responses in vivo: the role of CTLA4 and TH1/TH2 cytokines. Transplant Proc. 2001 Nov-Dec; 33(7-8):3826-8. PMID: 11750630.
    Citations: 2     Fields:    Translation:AnimalsCells
  82. Chitnis T, Najafian N, Benou C, Salama AD, Grusby MJ, Sayegh MH, Khoury SJ. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest. 2001 Sep; 108(5):739-47. PMID: 11544280; PMCID: PMC209380.
    Citations: 93     Fields:    Translation:AnimalsCells
  83. Najafian N, Khoury SJ, Sayegh MH. T cell costimulatory blockade as a novel immune intervention in autoimmune diseases. Clin Dermatol. 2001 Sep-Oct; 19(5):586-91. PMID: 11604305.
    Citations:    Fields:    Translation:HumansCells
  84. Waaga AM, Gasser M, Kist-van Holthe JE, Najafian N, Müller A, Vella JP, Womer KL, Chandraker A, Khoury SJ, Sayegh MH. Regulatory functions of self-restricted MHC class II allopeptide-specific Th2 clones in vivo. J Clin Invest. 2001 Apr; 107(7):909-16. PMID: 11285310; PMCID: PMC199572.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  85. Chitnis T, Najafian N, Abdallah KA, Dong V, Yagita H, Sayegh MH, Khoury SJ. CD28-independent induction of experimental autoimmune encephalomyelitis. J Clin Invest. 2001 Mar; 107(5):575-83. PMID: 11238558; PMCID: PMC199425.
    Citations: 23     Fields:    Translation:AnimalsCells
  86. Najafian N, Sayegh MH. CTLA4-Ig: a novel immunosuppressive agent. Expert Opin Investig Drugs. 2000 Sep; 9(9):2147-57. PMID: 11060799.
    Citations: 20     Fields:    Translation:HumansAnimals
  87. Schenk S, Breiteneder H, Susani M, Najafian N, Laffer S, Duchêne M, Valenta R, Fischer G, Scheiner O, Kraft D, Ebner C. T cell epitopes of Phl p 1, major pollen allergen of timothy grass (Phleum pratense). Crossreactivity with group I allergens of different grasses. Adv Exp Med Biol. 1996; 409:141-6. PMID: 9095234.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  88. Schenk S, Breiteneder H, Susani M, Najafian N, Laffer S, Duchêne M, Valenta R, Fischer G, Scheiner O, Kraft D, et al. T-cell epitopes of Phl p 1, major pollen allergen of timothy grass (Phleum pratense): evidence for crossreacting and non-crossreacting T-cell epitopes within grass group I allergens. J Allergy Clin Immunol. 1995 Dec; 96(6 Pt 1):986-96. PMID: 8543758.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  89. Ebner C, Siemann U, Najafian N, Scheiner O, Kraft D. Characterization of allergen (Bet v 1)-specific T cell lines and clones from non-allergic individuals. Int Arch Allergy Immunol. 1995 May-Jun; 107(1-3):183-5. PMID: 7542069.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  90. Ebner C, Schenk S, Najafian N, Siemann U, Steiner R, Fischer GW, Hoffmann K, Szépfalusi Z, Scheiner O, Kraft D. Nonallergic individuals recognize the same T cell epitopes of Bet v 1, the major birch pollen allergen, as atopic patients. J Immunol. 1995 Feb 15; 154(4):1932-40. PMID: 7530747.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Najafian's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (385)
Co-Authors (60)
Similar People (60)
Same Department 
Physical Neighbors
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.