Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Ganesh Mani Shankar, M.D., Ph.D.

Title
Institution
Department
Address
Phone
Fax

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shankar GM, Van Beaver LA, Choi BD, Hadzipasic M, Sivaganesan A, Karhade AV, Ferrone ML, Harris MB, Schoenfeld AJ, Sadow PM, Oh K, Schwab JH, Saylor PJ, Shin JH. Survival After Surgery for Renal Cell Carcinoma Metastatic to the Spine: Impact of Modern Systemic Therapies on Outcomes. Neurosurgery. 2020 Jun 10. PMID: 32521012.
    Citations:    
  2. Fatima N, Massaad E, Alvarez-Breckenridge C, Berry Candelario JE, Hadzipasic M, Shankar GM, Shin JH. Does Obesity Correlate with Postoperative Morbidity Following Elective Posterior Cervical Fusion Surgery? World Neurosurg. 2020 May 17. PMID: 32434032.
    Citations:    
  3. Fatima N, Zheng H, Massaad E, Hadzipasic M, Shankar GM, Shin JH. Development and Validation of Machine Learning Algorithms for Predicting Adverse Events Following Surgery for Lumbar Degenerative Spondylolisthesis. World Neurosurg. 2020 Apr 25. PMID: 32344139.
    Citations:    
  4. Massaad E, Fatima N, Kiapour A, Hadzipasic M, Shankar GM, Shin JH. Polyetheretherketone Versus Titanium Cages for Posterior Lumbar Interbody Fusion: Meta-Analysis and Review of the Literature. Neurospine. 2020 Mar; 17(1):125-135. PMID: 32252163.
    Citations:    
  5. Koffie RM, Larsen AG, Grannan BL, Hadzipasic M, Yanamadala V, Shankar GM, Van Beaver L, Shin JH. Novel Technique for C1-2 Interlaminar Arthrodesis Utilizing a Modified Sonntag Loop-Suture Graft With Posterior C1-2 Fixation. Neurospine. 2020 Feb 02. PMID: 32054143.
    Citations:    
  6. Fatima N, Barra ME, Roberts RJ, Massaad E, Hadzipasic M, Shankar GM, Shin JH. Advances in surgical hemostasis: a comprehensive review and meta-analysis on topical tranexamic acid in spinal deformity surgery. Neurosurg Rev. 2020 Jan 14. PMID: 31938967.
    Citations:    
  7. Fatima N, Massaad E, Shankar GM, Shin JH. Structural Allograft versus Polyetheretherketone Implants in Patients Undergoing Spinal Fusion Surgery: A Systematic Review and Meta-Analysis. World Neurosurg. 2020 Apr; 136:101-109. PMID: 31931246.
    Citations:    
  8. Massaad E, Fatima N, Hadzipasic M, Alvarez-Breckenridge C, Shankar GM, Shin JH. Predictive Analytics in Spine Oncology Research: First Steps, Limitations, and Future Directions. Neurospine. 2019 Dec; 16(4):669-677. PMID: 31905455.
    Citations:    
  9. Choi BD, Shankar GM, Sivaganesan A, Van Beaver LA, Oh K, Shin JH. Implication of Biomarker Mutations for Predicting Survival in Patients With Metastatic Lung Cancer to the Spine. Spine (Phila Pa 1976). 2018 Nov 01; 43(21):E1274-E1280. PMID: 29652780.
    Citations:    Fields:    
  10. Juratli TA, McCabe D, Nayyar N, Williams EA, Silverman IM, Tummala SS, Fink AL, Baig A, Martinez-Lage M, Selig MK, Bihun IV, Shankar GM, Penson T, Lastrapes M, Daubner D, Meinhardt M, Hennig S, Kaplan AB, Fujio S, Kuter BM, Bertalan MS, Miller JJ, Batten JM, Ely HA, Christiansen J, Baretton GB, Stemmer-Rachamimov AO, Santagata S, Rivera MN, Barker FG, Schackert G, Wakimoto H, Iafrate AJ, Carter SL, Cahill DP, Brastianos PK. DMD genomic deletions characterize a subset of progressive/higher-grade meningiomas with poor outcome. Acta Neuropathol. 2018 11; 136(5):779-792. PMID: 30123936.
    Citations:    Fields:    
  11. Shankar GM, Kirtane AR, Miller JJ, Mazdiyasni H, Rogner J, Tai T, Williams EA, Higuchi F, Juratli TA, Tateishi K, Koerner MVA, Tummala SS, Fink AL, Penson T, Schmidt SP, Wojtkiewicz GR, Baig A, Francis JM, Rinne ML, Batten JM, Batchelor TT, Brastianos PK, Curry WT, Barker FG, Jordan JT, Iafrate AJ, Chi AS, Lennerz JK, Meyerson M, Langer R, Wakimoto H, Traverso G, Cahill DP. Genotype-targeted local therapy of glioma. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):E8388-E8394. PMID: 30082399.
    Citations: 2     Fields:    Translation:HumansAnimals
  12. Sastry RA, Shankar GM, Gerstner ER, Curry WT. The impact of surgery on survival after progression of glioblastoma: A retrospective cohort analysis of a contemporary patient population. J Clin Neurosci. 2018 Jul; 53:41-47. PMID: 29680441.
    Citations:    Fields:    Translation:Humans
  13. Juratli TA, Thiede C, Koerner MVA, Tummala SS, Daubner D, Shankar GM, Williams EA, Martinez-Lage M, Soucek S, Robel K, Penson T, Krause M, Appold S, Meinhardt M, Pinzer T, Miller JJ, Krex D, Ely HA, Silverman IM, Christiansen J, Schackert G, Wakimoto H, Kirsch M, Brastianos PK, Cahill DP. Intratumoral heterogeneity and TERT promoter mutations in progressive/higher-grade meningiomas. Oncotarget. 2017 Dec 12; 8(65):109228-109237. PMID: 29312603.
    Citations: 2     Fields:    
  14. Shankar GM, Santagata S. BAP1 mutations in high-grade meningioma: implications for patient care. Neuro Oncol. 2017 Oct 19; 19(11):1447-1456. PMID: 28482042.
    Citations: 2     Fields:    Translation:Humans
  15. Shankar GM, Balaj L, Stott SL, Nahed B, Carter BS. Liquid biopsy for brain tumors. Expert Rev Mol Diagn. 2017 10; 17(10):943-947. PMID: 28875730.
    Citations: 2     Fields:    Translation:HumansCells
  16. Tateishi K, Higuchi F, Miller JJ, Koerner MVA, Lelic N, Shankar GM, Tanaka S, Fisher DE, Batchelor TT, Iafrate AJ, Wakimoto H, Chi AS, Cahill DP. The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1-Mutant Cancers and Potentiates NAD+ Depletion-Mediated Cytotoxicity. Cancer Res. 2017 08 01; 77(15):4102-4115. PMID: 28625978.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  17. Shankar GM, Choi BD, Grannan BL, Oh K, Shin JH. Effect of Immunotherapy Status on Outcomes in Patients With Metastatic Melanoma to the Spine. Spine (Phila Pa 1976). 2017 Jun 15; 42(12):E721-E725. PMID: 27879568.
    Citations:    Fields:    Translation:Humans
  18. Shankar GM, Clarke MJ, Ailon T, Rhines LD, Patel SR, Sahgal A, Laufer I, Chou D, Bilsky MH, Sciubba DM, Fehlings MG, Fisher CG, Gokaslan ZL, Shin JH. The role of revision surgery and adjuvant therapy following subtotal resection of osteosarcoma of the spine: a systematic review with meta-analysis. J Neurosurg Spine. 2017 Jul; 27(1):97-104. PMID: 28452631.
    Citations: 2     Fields:    Translation:Humans
  19. Shankar GM, Abedalthagafi M, Vaubel RA, Merrill PH, Nayyar N, Gill CM, Brewster R, Bi WL, Agarwalla PK, Thorner AR, Reardon DA, Al-Mefty O, Wen PY, Alexander BM, van Hummelen P, Batchelor TT, Ligon KL, Ligon AH, Meyerson M, Dunn IF, Beroukhim R, Louis DN, Perry A, Carter SL, Giannini C, Curry WT, Cahill DP, Barker FG, Brastianos PK, Santagata S. Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas. Neuro Oncol. 2017 04 01; 19(4):535-545. PMID: 28170043.
    Citations: 9     Fields:    Translation:Humans
  20. Friedman GN, Grannan BL, Yanamadala V, Shankar GM, Dewitt JC, Puthenpura V, Koffie RM, Macdonald SM, Ebb DH, Frosch MP, Duhaime AC. Rapid Neurological Recovery Following Partial Surgical Resection of Spinal Glioblastoma Multiforme in a Pediatric Patient Presenting With Complete Paraplegia. J Pediatr Hematol Oncol. 2016 11; 38(8):e286-e290. PMID: 27403775.
    Citations:    Fields:    Translation:Humans
  21. Lee D, Yanamadala V, Shankar GM, Shin JH. Metastatic adrenal cortical carcinoma to T12 vertebrae. J Clin Neurosci. 2016 May; 27:166-9. PMID: 26765762.
    Citations:    Fields:    Translation:Humans
  22. Yanamadala V, Koffie RM, Shankar GM, Kumar JI, Buchlak QD, Puthenpura V, Frosch MP, Gudewicz TM, Borges LF, Shin JH. Spinal cord glioblastoma: 25years of experience from a single institution. J Clin Neurosci. 2016 May; 27:138-41. PMID: 26755453.
    Citations: 2     Fields:    Translation:HumansCells
  23. Brastianos PK, Shankar GM, Gill CM, Taylor-Weiner A, Nayyar N, Panka DJ, Sullivan RJ, Frederick DT, Abedalthagafi M, Jones PS, Dunn IF, Nahed BV, Romero JM, Louis DN, Getz G, Cahill DP, Santagata S, Curry WT, Barker FG. Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy. J Natl Cancer Inst. 2016 Feb; 108(2). PMID: 26498373.
    Citations: 24     Fields:    Translation:Humans
  24. Shankar GM, Francis JM, Rinne ML, Ramkissoon SH, Huang FW, Venteicher AS, Akama-Garren EH, Kang YJ, Lelic N, Kim JC, Brown LE, Charbonneau SK, Golby AJ, Sekhar Pedamallu C, Hoang MP, Sullivan RJ, Cherniack AD, Garraway LA, Stemmer-Rachamimov A, Reardon DA, Wen PY, Brastianos PK, Curry WT, Barker FG, Hahn WC, Nahed BV, Ligon KL, Louis DN, Cahill DP, Meyerson M. Rapid Intraoperative Molecular Characterization of Glioma. JAMA Oncol. 2015 Aug; 1(5):662-7. PMID: 26181761.
    Citations: 13     Fields:    Translation:HumansCells
  25. Eisele SC, Gill CM, Shankar GM, Brastianos PK. PLEKHA5: A Key to Unlock the Blood-Brain Barrier? Clin Cancer Res. 2015 May 01; 21(9):1978-80. PMID: 25779946.
    Citations: 5     Fields:    Translation:Humans
  26. Shankar GM, Taylor-Weiner A, Lelic N, Jones RT, Kim JC, Francis JM, Abedalthagafi M, Borges LF, Coumans JV, Curry WT, Nahed BV, Shin JH, Paek SH, Park SH, Stewart C, Lawrence MS, Cibulskis K, Thorner AR, Van Hummelen P, Stemmer-Rachamimov AO, Batchelor TT, Carter SL, Hoang MP, Santagata S, Louis DN, Barker FG, Meyerson M, Getz G, Brastianos PK, Cahill DP. Sporadic hemangioblastomas are characterized by cryptic VHL inactivation. Acta Neuropathol Commun. 2014 Dec 24; 2:167. PMID: 25589003.
    Citations: 6     Fields:    Translation:HumansCells
  27. Shankar GM, Barker FG. Primary CNS lymphoma: the role of resection. Oncology (Williston Park). 2014 Jul; 28(7):637-8, 640, 642. PMID: 25144287.
    Citations: 2     Fields:    Translation:Humans
  28. Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ. Secreted amyloid ß-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity. Biochemistry. 2014 Jun 24; 53(24):3908-21. PMID: 24840308.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  29. Diamond EL, Kimchi EY, Shankar GM, Silverman SB. Transient aqueductal occlusion in intracerebral haemorrhage. Pract Neurol. 2012 Dec; 12(6):388-9. PMID: 23144305.
    Citations:    Fields:    Translation:Humans
  30. Fu H, Liu B, Frost JL, Hong S, Jin M, Ostaszewski B, Shankar GM, Costantino IM, Carroll MC, Mayadas TN, Lemere CA. Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aß by microglia. Glia. 2012 May; 60(6):993-1003. PMID: 22438044.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  31. Shepardson NE, Shankar GM, Selkoe DJ. Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations. Arch Neurol. 2011 Nov; 68(11):1385-92. PMID: 22084122.
    Citations: 43     Fields:    Translation:HumansAnimals
  32. Shepardson NE, Shankar GM, Selkoe DJ. Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies. Arch Neurol. 2011 Oct; 68(10):1239-44. PMID: 21987540.
    Citations: 50     Fields:    Translation:HumansAnimals
  33. Li S, Jin M, Koeglsperger T, Shepardson NE, Shankar GM, Selkoe DJ. Soluble Aß oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J Neurosci. 2011 May 04; 31(18):6627-38. PMID: 21543591.
    Citations: 169     Fields:    Translation:AnimalsCells
  34. Shankar GM, Welzel AT, McDonald JM, Selkoe DJ, Walsh DM. Isolation of low-n amyloid ß-protein oligomers from cultured cells, CSF, and brain. Methods Mol Biol. 2011; 670:33-44. PMID: 20967581.
    Citations: 26     Fields:    Translation:HumansCells
  35. Shankar GM, Chen L, Kim AH, Ross GL, Folkerth RD, Friedlander RM. Composite ganglioneuroma-paraganglioma of the filum terminale. J Neurosurg Spine. 2010 Jun; 12(6):709-13. PMID: 20515359.
    Citations: 4     Fields:    Translation:Humans
  36. Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM. The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain. 2010 May; 133(Pt 5):1328-41. PMID: 20403962.
    Citations: 92     Fields:    Translation:HumansCells
  37. Li S, Shankar GM, Selkoe DJ. How do Soluble Oligomers of Amyloid beta-protein Impair Hippocampal Synaptic Plasticity? Front Cell Neurosci. 2010; 4:5. PMID: 20428510.
    Citations: 14     
  38. Shankar GM, Walsh DM. Alzheimer's disease: synaptic dysfunction and Abeta. Mol Neurodegener. 2009 Nov 23; 4:48. PMID: 19930651.
    Citations: 118     Fields:    
  39. Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiol Dis. 2009 Nov; 36(2):293-302. PMID: 19660551.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  40. Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM, Selkoe D. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron. 2009 Jun 25; 62(6):788-801. PMID: 19555648.
    Citations: 270     Fields:    Translation:HumansAnimalsCells
  41. Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJ. A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. Arch Neurol. 2009 Feb; 66(2):190-9. PMID: 19204155.
    Citations: 59     Fields:    Translation:HumansCells
  42. Irvine GB, El-Agnaf OM, Shankar GM, Walsh DM. Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases. Mol Med. 2008 Jul-Aug; 14(7-8):451-64. PMID: 18368143.
    Citations: 102     Fields:    Translation:Humans
  43. Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008 Aug; 14(8):837-42. PMID: 18568035.
    Citations: 1123     Fields:    Translation:HumansAnimalsCells
  44. Shen C, Wang Z, Shankar G, Zhang X, Li L. A hierarchical statistical model to assess the confidence of peptides and proteins inferred from tandem mass spectrometry. Bioinformatics. 2008 Jan 15; 24(2):202-8. PMID: 18024968.
    Citations: 15     Fields:    
  45. Lo KC, Shankar G, Turpaz Y, Bailey D, Rossi MR, Burkhardt T, Liang P, Cowell JK. Overlay tool for aCGHViewer: an analysis module built for aCGHViewer used to perform comparisons of data derived from different microarray platforms. Cancer Inform. 2007 Aug 08; 3:307-19. PMID: 19455250.
    Citations: 1     
  46. Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. Am J Pathol. 2007 Jul; 171(1):241-51. PMID: 17591969.
    Citations: 47     Fields:    Translation:HumansAnimals
  47. Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci. 2007 Mar 14; 27(11):2866-75. PMID: 17360908.
    Citations: 509     Fields:    Translation:HumansAnimalsCells
  48. Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ. Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J Physiol. 2006 Apr 15; 572(Pt 2):477-92. PMID: 16469784.
    Citations: 187     Fields:    Translation:AnimalsCells
  49. Shankar G, Rossi MR, McQuaid DE, Conroy JM, Gaile DG, Cowell JK, Nowak NJ, Liang P. aCGHViewer: a generic visualization tool for aCGH data. Cancer Inform. 2006; 2:36-43. PMID: 17404607.
    Citations: 5     
  50. Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe KH, Rowan MJ, Selkoe DJ. The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention. Biochem Soc Trans. 2005 Nov; 33(Pt 5):1087-90. PMID: 16246051.
    Citations: 75     Fields:    Translation:Humans
  51. Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med. 2005 May; 11(5):556-61. PMID: 15834427.
    Citations: 159     Fields:    Translation:AnimalsCellsPHPublic Health
  52. Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ. Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation. J Neurosci. 2005 Mar 09; 25(10):2455-62. PMID: 15758153.
    Citations: 83     Fields:    Translation:AnimalsCells
  53. Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci. 2005 Jan; 8(1):79-84. PMID: 15608634.
    Citations: 521     Fields:    Translation:HumansAnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Shankar's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (257)
Explore
_
Co-Authors (73)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.