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Mei-Hua Hall, Ph.D.

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Overview
I have a broad background in clinical psychology, epidemiology, statistical modeling, in addition to specific training and expertise in electrophysiology, psychiatric genetics and cognitive neuroscience. I continue to weave these interests together in my work with patients with psychotic disorders. I have conducted several neurobiological and genetics projects and have published papers spanning from characterizing event related potentials (ERP) deficits as potential endophenotypic markers (biomarkers) across psychotic spectrum disorders; identifying distinct subgroups of psychotic patients on the basis of neurobiological signatures that transcend diagnostic classification; to examining genetic and environmental risk factors for psychiatric disorders. My long-term interests are to gain a deep insight of the interplay between neurobiological mechanisms underlying psychotic disorders and environmental risks contributing to the development of illnesses and to utilize this knowledge for developing implementable and effective precision medicine tools or strategies in clinical services.
I am the PI of a NIMH funded longitudinal study (R01) that involves leveraging multivariate biomarkers (e.g., EEG, MRI, cognition, clinical phenotypes), each of which has been well studied in the psychosis literature, to stratify first episode psychosis patients into homogeneous subgroups based on patients’ unique neuro-biological profiles and relate these profiles to their functional outcome trajectories. The goal is to identify and predict patients who are not likely to achieve functional recovery and are at risk of relapse (readmission). To achieve this goal, my team and collaborators are developing computational tools using natural language processing (NLP) and machine learning algorithms to integrate both structured biomarker and unstructured clinical electronic health records (EHRs) data in the data analysis pipeline in order to augment knowledge discovery and to develop robust risk prediction models.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03MH108850 (HALL, MEI-HUA) Aug 19, 2016 - Jun 30, 2018
    NIH/NIMH
    Genetic Basis of Reward Learning and Symptom, Smoking, and Neural Signature Correlates
    Role: Principal Investigator
  2. R01MH109687 (HALL, MEI-HUA) Mar 17, 2016 - Jan 31, 2021
    NIH/NIMH
    Neurobiological Markers as Predictors of Later Functional Outcome in First Episode Psychosis
    Role: Principal Investigator
  3. K01MH086714 (HALL, MEI-HUA) Jun 1, 2010 - May 31, 2015
    NIH/NIMH
    Functional Characterization of Risk Variants for Psychotic Illness in the GWAS Er
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chan SY, Brady R, Hwang M, Higgins A, Nielsen K, Öngür D, Hall MH. Heterogeneity of Outcomes and Network Connectivity in Early-Stage Psychosis: A Longitudinal Study. Schizophr Bull. 2020 Jun 23. PMID: 32572485.
    Citations:    
  2. Keshavan MS, Kelly S, Hall MH. Can J Psychiatry. 2020 Apr; 65(4):231-234. PMID: 31961197.
    Citations:    
  3. Holderness E, Miller N, Cawkwell P, Bolton K, Meteer M, Pustejovsky J, Hall MH. Analysis of risk factor domains in psychosis patient health records. J Biomed Semantics. 2019 10 31; 10(1):19. PMID: 31672168.
    Citations:    
  4. Guffanti G, Kumar P, Admon R, Treadway MT, Hall MH, Mehta M, Douglas S, Arulpragasam AR, Pizzagalli DA. Depression genetic risk score is associated with anhedonia-related markers across units of analysis. Transl Psychiatry. 2019 09 19; 9(1):236. PMID: 31537779.
    Citations:    
  5. Monaghan CK, Brickman S, Huynh P, Öngür D, Hall MH. A longitudinal study of event related potentials and correlations with psychosocial functioning and clinical features in first episode psychosis patients. Int J Psychophysiol. 2019 11; 145:48-56. PMID: 31108121.
    Citations:    
  6. Hall MH, Holton KM, Öngür D, Montrose D, Keshavan MS. Longitudinal trajectory of early functional recovery in patients with first episode psychosis. Schizophr Res. 2019 07; 209:234-244. PMID: 30826261.
    Citations:    
  7. Lee I, Nielsen K, Nawaz U, Hall MH, Öngür D, Keshavan M, Brady R. Diverse pathophysiological processes converge on network disruption in mania. J Affect Disord. 2019 02 01; 244:115-123. PMID: 30340100.
    Citations:    Fields:    
  8. Zhou TH, Mueller NE, Spencer KM, Mallya SG, Lewandowski KE, Norris LA, Levy DL, Cohen BM, Öngür D, Hall MH. Auditory steady state response deficits are associated with symptom severity and poor functioning in patients with psychotic disorder. Schizophr Res. 2018 11; 201:278-286. PMID: 29807805.
    Citations:    Fields:    
  9. Lin YF, Chen CY, Öngür D, Betensky R, Smoller JW, Blacker D, Hall MH. Polygenic pleiotropy and potential causal relationships between educational attainment, neurobiological profile, and positive psychotic symptoms. Transl Psychiatry. 2018 05 16; 8(1):97. PMID: 29765027.
    Citations:    Fields:    Translation:Humans
  10. Lewandowski KE, Whitton AE, Pizzagalli DA, Norris LA, Ongur D, Hall MH. Reward Learning, Neurocognition, Social Cognition, and Symptomatology in Psychosis. Front Psychiatry. 2016; 7:100. PMID: 27378952.
    Citations: 7     
  11. Hall MH, Chen CY, Cohen BM, Spencer KM, Levy DL, Öngür D, Smoller JW. Genomewide association analyses of electrophysiological endophenotypes for schizophrenia and psychotic bipolar disorders: a preliminary report. Am J Med Genet B Neuropsychiatr Genet. 2015 Apr; 168B(3):151-61. PMID: 25740047.
    Citations: 4     Fields:    Translation:Humans
  12. Hall MH, Jensen JE, Du F, Smoller JW, O'Connor L, Spencer KM, Öngür D. Frontal P3 event-related potential is related to brain glutamine/glutamate ratio measured in vivo. Neuroimage. 2015 May 01; 111:186-91. PMID: 25687595.
    Citations: 4     Fields:    Translation:Humans
  13. Hall MH, Levy DL, Salisbury DF, Haddad S, Gallagher P, Lohan M, Cohen B, Ongür D, Smoller JW. Neurophysiologic effect of GWAS derived schizophrenia and bipolar risk variants. Am J Med Genet B Neuropsychiatr Genet. 2014 Jan; 165B(1):9-18. PMID: 24339136.
    Citations: 10     Fields:    Translation:Humans
  14. Hall MH, Smoller JW, Cook NR, Schulze K, Hyoun Lee P, Taylor G, Bramon E, Coleman MJ, Murray RM, Salisbury DF, Levy DL. Patterns of deficits in brain function in bipolar disorder and schizophrenia: a cluster analytic study. Psychiatry Res. 2012 Dec 30; 200(2-3):272-80. PMID: 22925372.
    Citations: 5     Fields:    Translation:Humans
  15. Shaikh M, Hall MH, Schulze K, Dutt A, Li K, Williams I, Walshe M, Constante M, Broome M, Picchioni M, Toulopoulou T, Collier D, Stahl D, Rijsdijk F, Powell J, Murray RM, Arranz M, Bramon E. Effect of DISC1 on the P300 waveform in psychosis. Schizophr Bull. 2013 Jan; 39(1):161-7. PMID: 21878470.
    Citations: 9     Fields:    Translation:Humans
  16. Hall MH, Spencer KM, Schulze K, McDonald C, Kalidindi S, Kravariti E, Kane F, Murray RM, Bramon E, Sham P, Rijsdijk F. The genetic and environmental influences of event-related gamma oscillations on bipolar disorder. Bipolar Disord. 2011 May; 13(3):260-71. PMID: 21676129.
    Citations: 5     Fields:    Translation:Humans
  17. Schulze KK, Walshe M, Stahl D, Hall MH, Kravariti E, Morris R, Marshall N, McDonald C, Murray RM, Bramon E. Executive functioning in familial bipolar I disorder patients and their unaffected relatives. Bipolar Disord. 2011 Mar; 13(2):208-16. PMID: 21443575.
    Citations: 12     Fields:    Translation:Humans
  18. Bloch-Salisbury E, Hall MH, Sharma P, Boyd T, Bednarek F, Paydarfar D. Heritability of apnea of prematurity: a retrospective twin study. Pediatrics. 2010 Oct; 126(4):e779-87. PMID: 20837586.
    Citations: 3     Fields:    Translation:Humans
  19. Ettinger U, Schmechtig A, Toulopoulou T, Borg C, Orrells C, Owens S, Matsumoto K, van Haren NE, Hall MH, Kumari V, McGuire PK, Murray RM, Picchioni M. Prefrontal and striatal volumes in monozygotic twins concordant and discordant for schizophrenia. Schizophr Bull. 2012 Jan; 38(1):192-203. PMID: 20538831.
    Citations: 17     Fields:    Translation:Humans
  20. Surguladze SA, Marshall N, Schulze K, Hall MH, Walshe M, Bramon E, Phillips ML, Murray RM, McDonald C. Exaggerated neural response to emotional faces in patients with bipolar disorder and their first-degree relatives. Neuroimage. 2010 Oct 15; 53(1):58-64. PMID: 20595014.
    Citations: 42     Fields:    Translation:Humans
  21. Hall MH, Taylor G, Salisbury DF, Levy DL. Sensory gating event-related potentials and oscillations in schizophrenia patients and their unaffected relatives. Schizophr Bull. 2011 Nov; 37(6):1187-99. PMID: 20363872.
    Citations: 29     Fields:    Translation:Humans
  22. Allin MP, Marshall N, Schulze K, Walshe M, Hall MH, Picchioni M, Murray RM, McDonald C. A functional MRI study of verbal fluency in adults with bipolar disorder and their unaffected relatives. Psychol Med. 2010 Dec; 40(12):2025-35. PMID: 20146832.
    Citations: 8     Fields:    Translation:Humans
  23. Shaikh M, Hall MH, Schulze K, Dutt A, Walshe M, Williams I, Constante M, Picchioni M, Toulopoulou T, Collier D, Rijsdijk F, Powell J, Arranz M, Murray RM, Bramon E. Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis? Psychol Med. 2011 Feb; 41(2):263-76. PMID: 20102668.
    Citations: 14     Fields:    Translation:Humans
  24. Hall MH, Smoller JW. A new role for endophenotypes in the GWAS era: functional characterization of risk variants. Harv Rev Psychiatry. 2010 Jan-Feb; 18(1):67-74. PMID: 20047462.
    Citations: 25     Fields:    Translation:Humans
  25. Hall MH, Taylor G, Sham P, Schulze K, Rijsdijk F, Picchioni M, Toulopoulou T, Ettinger U, Bramon E, Murray RM, Salisbury DF. The early auditory gamma-band response is heritable and a putative endophenotype of schizophrenia. Schizophr Bull. 2011 Jul; 37(4):778-87. PMID: 19946013.
    Citations: 41     Fields:    Translation:Humans
  26. Chaddock CA, Barker GJ, Marshall N, Schulze K, Hall MH, Fern A, Walshe M, Bramon E, Chitnis XA, Murray R, McDonald C. White matter microstructural impairments and genetic liability to familial bipolar I disorder. Br J Psychiatry. 2009 Jun; 194(6):527-34. PMID: 19478293.
    Citations: 48     Fields:    Translation:Humans
  27. Hall MH, Schulze K, Rijsdijk F, Kalidindi S, McDonald C, Bramon E, Murray RM, Sham P. Are auditory P300 and duration MMN heritable and putative endophenotypes of psychotic bipolar disorder? A Maudsley Bipolar Twin and Family Study. Psychol Med. 2009 Aug; 39(8):1277-87. PMID: 19250581.
    Citations: 30     Fields:    Translation:Humans
  28. Kravariti E, Schulze K, Kane F, Kalidindi S, Bramon E, Walshe M, Marshall N, Hall MH, Georgiades A, McDonald C, Murray RM. Stroop-test interference in bipolar disorder. Br J Psychiatry. 2009 Mar; 194(3):285-6. PMID: 19252161.
    Citations: 8     Fields:    Translation:Humans
  29. Hall MH, Schulze K, Sham P, Kalidindi S, McDonald C, Bramon E, Levy DL, Murray RM, Rijsdijk F. Further evidence for shared genetic effects between psychotic bipolar disorder and P50 suppression: a combined twin and family study. Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 05; 147B(5):619-27. PMID: 18189279.
    Citations: 11     Fields:    Translation:Humans
  30. Drapier D, Surguladze S, Marshall N, Schulze K, Fern A, Hall MH, Walshe M, Murray RM, McDonald C. Genetic liability for bipolar disorder is characterized by excess frontal activation in response to a working memory task. Biol Psychiatry. 2008 Sep 15; 64(6):513-20. PMID: 18571627.
    Citations: 23     Fields:    Translation:Humans
  31. Schulze KK, Hall MH, McDonald C, Marshall N, Walshe M, Murray RM, Bramon E. Auditory P300 in patients with bipolar disorder and their unaffected relatives. Bipolar Disord. 2008 May; 10(3):377-86. PMID: 18402626.
    Citations: 21     Fields:    Translation:Humans
  32. Hall MH, Rijsdijk F. Validating endophenotypes for schizophrenia using statistical modeling of twin data. Clin EEG Neurosci. 2008 Apr; 39(2):78-81. PMID: 18450173.
    Citations: 1     Fields:    Translation:Humans
  33. Toulopoulou T, Picchioni M, Rijsdijk F, Hua-Hall M, Ettinger U, Sham P, Murray R. Substantial genetic overlap between neurocognition and schizophrenia: genetic modeling in twin samples. Arch Gen Psychiatry. 2007 Dec; 64(12):1348-55. PMID: 18056542.
    Citations: 58     Fields:    Translation:Humans
  34. Martin LF, Hall MH, Ross RG, Zerbe G, Freedman R, Olincy A. Physiology of schizophrenia, bipolar disorder, and schizoaffective disorder. Am J Psychiatry. 2007 Dec; 164(12):1900-6. PMID: 18056246.
    Citations: 16     Fields:    Translation:Humans
  35. Martin LF, Leonard S, Hall MH, Tregellas JR, Freedman R, Olincy A. Sensory gating and alpha-7 nicotinic receptor gene allelic variants in schizoaffective disorder, bipolar type. Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 05; 144B(5):611-4. PMID: 17192894.
    Citations: 11     Fields:    Translation:HumansCells
  36. Hall MH, Rijsdijk F, Picchioni M, Schulze K, Ettinger U, Toulopoulou T, Bramon E, Murray RM, Sham P. Substantial shared genetic influences on schizophrenia and event-related potentials. Am J Psychiatry. 2007 May; 164(5):804-12. PMID: 17475740.
    Citations: 30     Fields:    Translation:Humans
  37. Ettinger U, Picchioni M, Landau S, Matsumoto K, van Haren NE, Marshall N, Hall MH, Schulze K, Toulopoulou T, Davies N, Ribchester T, McGuire PK, Murray RM. Magnetic resonance imaging of the thalamus and adhesio interthalamica in twins with schizophrenia. Arch Gen Psychiatry. 2007 Apr; 64(4):401-9. PMID: 17404117.
    Citations: 20     Fields:    Translation:Humans
  38. Hall MH, Rijsdijk F, Kalidindi S, Schulze K, Kravariti E, Kane F, Sham P, Bramon E, Murray RM. Genetic overlap between bipolar illness and event-related potentials. Psychol Med. 2007 May; 37(5):667-78. PMID: 17224092.
    Citations: 13     Fields:    Translation:Humans
  39. Schulze KK, Hall MH, McDonald C, Marshall N, Walshe M, Murray RM, Bramon E. P50 auditory evoked potential suppression in bipolar disorder patients with psychotic features and their unaffected relatives. Biol Psychiatry. 2007 Jul 15; 62(2):121-8. PMID: 17123476.
    Citations: 25     Fields:    Translation:Humans
  40. Faraone SV, Hwu HG, Liu CM, Chen WJ, Tsuang MM, Liu SK, Shieh MH, Hwang TJ, Ou-Yang WC, Chen CY, Chen CC, Lin JJ, Chou FH, Chueh CM, Liu WM, Hall MH, Su J, Van Eerdewegh P, Tsuang MT. Genome scan of Han Chinese schizophrenia families from Taiwan: confirmation of linkage to 10q22.3. Am J Psychiatry. 2006 Oct; 163(10):1760-6. PMID: 17012687.
    Citations: 24     Fields:    Translation:HumansCells
  41. Hall MH, Schulze K, Rijsdijk F, Picchioni M, Ettinger U, Bramon E, Freedman R, Murray RM, Sham P. Heritability and reliability of P300, P50 and duration mismatch negativity. Behav Genet. 2006 Nov; 36(6):845-57. PMID: 16826459.
    Citations: 37     Fields:    Translation:Humans
  42. Hall MH, Schulze K, Bramon E, Murray RM, Sham P, Rijsdijk F. Genetic overlap between P300, P50, and duration mismatch negativity. Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 05; 141B(4):336-43. PMID: 16649211.
    Citations: 16     Fields:    Translation:Humans
  43. Ettinger U, Picchioni M, Hall MH, Schulze K, Toulopoulou T, Landau S, Crawford TJ, Murray RM. Antisaccade performance in monozygotic twins discordant for schizophrenia: the Maudsley twin study. Am J Psychiatry. 2006 Mar; 163(3):543-5. PMID: 16513882.
    Citations: 24     Fields:    Translation:Humans
  44. Hwu HG, Faraone SV, Liu CM, Chen WJ, Liu SK, Shieh MH, Hwang TJ, Tsuang MM, OuYang WC, Chen CY, Chen CC, Lin JJ, Chou FH, Chueh CM, Liu WM, Hall MH, Tsuang MT. Taiwan schizophrenia linkage study: the field study. Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 05; 134B(1):30-6. PMID: 15685625.
    Citations: 14     Fields:    Translation:Humans
  45. Adler LE, Olincy A, Cawthra EM, McRae KA, Harris JG, Nagamoto HT, Waldo MC, Hall MH, Bowles A, Woodward L, Ross RG, Freedman R. Varied effects of atypical neuroleptics on P50 auditory gating in schizophrenia patients. Am J Psychiatry. 2004 Oct; 161(10):1822-8. PMID: 15465979.
    Citations: 49     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.